‘They do not understand us’: a psychosocial analysis of the everyday lived experiences of a CYCC care worker in semi-rural South Africa
- Authors: Pieters, Cinnamon-Paige
- Date: 2022-04-07
- Subjects: Child care workers South Africa Attitudes , Narrative inquiry (Research method) , Intersubjectivity , Free association (Psychology) , Child care South Africa Psychological aspects , Burn out (Psychology) South Africa
- Language: English
- Type: Article , text
- Identifier: http://hdl.handle.net/10962/294482 , vital:57225
- Description: This paper employs a psychosocial framework to analyse the everyday lived experiences of a child and youth care worker in semi-rural South Africa. The aim is to provide a new perspective of care work by drawing on narrative analysis alongside a psychoanalytic approach to qualitative research. With an emphasis on the socially constructed nature of reality, the researcher aims to elucidate the rich unconscious depths of being a care worker and the dynamics of the intersubjective reality of care work. Employing a free association narrative interview technique allows the researcher to gain understanding of the narratives that the care worker draws on in the construction of his identity as a care worker. The use of a psychosocial approach enables the researcher to pay attention to both the social context that influences the narratives that he draws on, but also the psychological ‘pay offs’ of these constructions. Most notably, the study highlights how the care worker’s identity is mediated by a defended subjectivity and argues that his failures in mentalization might stem from the way he is treated as a care worker by other professionals as a result of their mindblindness. This maintains his narrative of invisibility, and the pervasive feeling of being misunderstood as a professional in his own right. The findings are discussed in terms of their contribution to understanding some of the challenges that CYCC care workers face. , Research Article (MA) -- Faculty of Humanities, Psychology, 2022
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Retracted COVID-19 Papers and the level of 'citation pollution': a preliminary analysis and directions for future research
- Authors: Van der Walt, Wynand , Willems, Kris A , Friedrich, Wernher , Hatsu, Sylvester , Krauss, Kirstin
- Date: 2020
- Subjects: Retraction watch , Research -- Evaluation , Bibliographical citations -- Evaluation , Science publishing -- Corrupt practices , Scholarly publishing -- Corrupt practices , Learning and scholarship -- Corrupt practices , Medical publishing -- Corrupt practices , COVID-19 (Disease) -- Publishing
- Language: English
- Type: Article , text
- Identifier: http://hdl.handle.net/10962/167732 , vital:41508 , https://www.abd-bvd.be/nl/bladen-voor-documentatie/2020-3-4/
- Description: Retraction Watch maintains a "running list" of retracted papers on Covid-19 related research. By the end of September 2020, thirty-three retracted Covid-19 papers were listed. We analysed these retracted papers, focusing specifically on how they have been cited by review papers, and subsequently how they have penetrated and potentially distorted public discourse and legitimate research on Covid-19. The study demonstrates the need for more in-depth studies that focus on the phenomenon of citation pollution. We show that the "Covid-19 publication race", amplified by a pressure-to-publish research culture, distorted published science on Covid-19. We highlight the urgency to engage popular media and critical decision makers on how to distinguish between questionable and legitimate science. We also emphasise the importance of dealing with illegitimate research in a timely manner, both from a scholarly communications and research quality perspective. , Retraction Watch maintient une "liste courante" des articles rétractés sur les recherches liées au Covid-19. Fin septembre 2020, trente-trois articles rétractés sur le Covid-19 étaient répertoriés. Nous avons analysé ces articles rétractés, en nous concentrant spécifiquement sur la façon dont ils ont été cités par d'autres articles, et ensuite sur la façon dont ils ont pénétré et potentiellement faussé le discours public et la recherche légitime sur le Covid-19. L'étude démontre le besoin d'études plus approfondies qui se concentrent sur le phénomène de la pollution des citations. Nous montrons que la "course à la publication sur le Covid-19", amplifiée par une culture de la pression à la publication de la recherche, a déformé l'information scientifique publiée sur le Covid-19. Nous soulignons l'urgence d'engager les médias populaires et les décideurs critiques sur la manière de distinguer la science douteuse de la science légitime. Nous soulignons également l'importance de traiter rapidement les recherches illégitimes, tant du point de vue de la communication scientifique que de la qualité de la recherche. , Retraction Watch houdt een "lopende lijst" bij van ingetrokken papieren over Covid-19-gerelateerd onderzoek. Eind september 2020 waren drieëndertig ingetrokken Covid-19 papieren op de lijst geplaatst. We hebben deze ingetrokken papieren geanalyseerd, waarbij we ons specifiek hebben gericht op de manier waarop ze zijn geciteerd door review papers, en vervolgens op de manier waarop ze zijn doorgedrongen en mogelijk vervormd in het publieke discours en het legitieme onderzoek naar Covid-19. De studie toont aan dat er behoefte is aan meer diepgaande studies die zich richten op het fenomeen van de citatievervuiling. We tonen aan dat de "Covid-19-publicatierace", versterkt door een druk om te publiceren onderzoekscultuur, de gepubliceerde wetenschap over Covid-19 vertekend heeft. We benadrukken de urgentie om de populaire media en kritische besluitvormers te betrekken bij het maken van een onderscheid tussen twijfelachtige en legitieme wetenschap. We benadrukken ook het belang van het tijdig aanpakken van onrechtmatig onderzoek, zowel vanuit het oogpunt van wetenschappelijke communicatie als vanuit het oogpunt van de kwaliteit van het onderzoek.
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The law of divorce and dissolution of life partnerships in South Africa: book review
- Authors: Kruuse, Helen
- Date: 2015
- Language: English
- Type: Article , text
- Identifier: http://hdl.handle.net/10962/54129 , vital:26394 , http://scholar.ufs.ac.za:8080/xmlui/handle/11660/2454
- Description: Jackie Heaton’s latest contribution to the family law domain is formidable – 777 pages of carefully crafted opinions and discussions of the law affecting divorce and dissolution of life partnerships. Given the range, diversity and depth of issues in this area, it is no wonder that she calls on those being among the best in their field to assist her in writing up the book.
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The relationship between concurrently measured SASS (South African Scoring System) and turbidity data archived in the South African River Health Programme’s Rivers Database
- Authors: Gordon, Andrew K , Griffin, Neil J , Palmer, Carolyn G
- Date: 2015
- Language: English
- Type: text , Article
- Identifier: vital:7098 , http://hdl.handle.net/10962/d1015956
- Description: The need for monitoring the biological impacts of instream sediments has long been recognised, yet robust and scientifically defensible tools for doing so are still in the early stages of development because of the difficulties experienced by researchers in characterising the complicated mechanisms of biological effect elicited by sediment particles. Biological monitoring is one such tool, and this paper reports on the initial stages of a study to determine the most applicable approach for measuring the effects of instream sediments on aquatic macroinvertebrates in the South African context. In this first instance, the suitability of the rapid macroinvertebrate biomonitoring tool (the South African Scoring System) was investigated by determining the extent of the correlation between concurrently measured SASS metrics and turbidity data collected for the South African River Health Programme. All three SASS metrics – SASS score, number of taxa (NOT), and average score per taxon (ASPT) – were found to be significantly negatively correlated with turbidity, although variation in the data was high. Turbidity was found to be the major driver of change in ASPT. In contrast, electrical conductivity was the major driver of SASS scores and NOT, with turbidity a close second. When combined, electrical conductivity and turbidity accounted for 80 percent (SASS score) and 75 percent (NOT) of the variation in the regression model. Consequently, SASS metrics are a crude, but reliable, indicator of the negative biological implications of excessive instream sedimentation as measured by turbidity. A number of other potential biomonitoring approaches for detecting the impacts of fine sediment exposure are identified for further investigation: spatial analyses of macroinvertebrate assemblages; and the use of structural and functional metrics.
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Bells as memorials in South Africa to the Great (1914-18) War
- Authors: Lewis, Colin A , De Wet, Tertius , Teugels, Jet L , Van Deventer, Pieta J U
- Date: 2014
- Language: English
- Type: Article , text
- Identifier: vital:6192 , http://hdl.handle.net/10962/d1013418
- Description: The contribution of South Africa to the allied cause in the Great War, and the sacrifice of so many lives of the White and Coloured populations, is memorialised on bells of the Cape Town carillon, on ringing, and on clock and other bells. The contribution of the Black population awaits recognition. Restoration of the Cape Town carillon so that it can again be played effectively, would be a fitting memorial to those who lost their lives in the non-combative roles that were open to the majority population of South Africa. Completion of the ring at what is now Queenstown cathedral would also be a fitting tribute to the bravery and unstinting service of so many South Africans during the Great War. , Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
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Sailing between Scylla and Charybdis: Mayelane v Ngwenyama
- Authors: Kruuse, Helen
- Date: 2014
- Language: English
- Type: Article , text
- Identifier: http://hdl.handle.net/10962/54118 , vital:26392 , https://www.ajol.info/index.php/pelj/article/view/112096
- Description: Mayelane v Ngwenyama 2013 4 SA 415 (CC) is arguably the most important judgment concerning the recognition of customary marriages in recent times. This article attempts to unpack some of the many issues that arise from the case, namely: (a) the practical difficulties associated with ascertaining living customary law and the problems of identifying legal versus social norms; (b) the meaning of consent as a requirement of a customary marriage; (c) the implications of the case for equality between multiple wives in a customary marriage, and as between wives across customary marriages of different cultural traditions; and (e) the implications of the case for equality considerations more broadly. While the authors sympathise with the court in respect of the complex decision before it, it questions the Court's method and result, specifically for the equality rights of a second (or further) "wife" in a Vatsonga customary marriage. The authors suggest that the issues should be put to democratic deliberation by the legislative arm, rather than leaving courts in the unenviable position of having to decide these matters.
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A tale of two neglected systems-structure and function of the thin- and thick-walled sieve tubes in monocotyledonous leaves
- Authors: Botha, Christiaan E J
- Date: 2013
- Language: English
- Type: Article , text
- Identifier: vital:6499 , http://hdl.handle.net/10962/d1004514 , http://dx.doi.org/10.3389/fpls.2013.00297
- Description: There is a large body of information relating to the ontogeny, development and the vasculature of eudicotyledonous leaves. However, there is less information available concerning the vascular anatomy of monocotyledonous leaves. This is surprising, given that there are two uniquely different phloem systems present in large groups such as grasses and sedges. Monocotyledonous leaves contain marginal, large, intermediate, and small longitudinal veins that are interconnected by numerous transverse veins. The longitudinal veins contain two metaphloem sieve tube types, which, based upon their ontogeny and position within the phloem, are termed early (thin-walled) and late (thick-walled) sieve tubes. Early metaphloem comprises sieve tubes, companion cells and vascular parenchyma (VP) cells, whilst the late metaphloem, contains thick-walled sieve tubes (TSTs) that lack companion cells. TSTs are generally adjacent to, or no more than one cell removed from the metaxylem. Unlike thin-walled sieve tube (ST) -companion cell complexes, TSTs are connected to parenchyma by pore-plasmodesma units and are generally symplasmically isolated from the STs. This paper addresses key structural and functional differences between thin- and thick-walled sieve tubes and explores the unique advantages of alternate transport strategies that this 5–7 million years old dual system may offer. It would seem that these two systems may enhance, add to, or play a significant role in increasing the efficiency of solute retrieval as well as of assimilate transfer.
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Curriculum Vitae of Prof Tebello Nyokong (OMB)
- Authors: Nyokong, Tebello
- Date: 2013
- Language: English
- Type: Article , text
- Identifier: vital:7233 , http://hdl.handle.net/10962/d1006180
- Description: Department of Science and Technology (DST) and National Research Foundation (NRF) Professor of Medicinal Chemistry and Nanotechnology and Distinguished Professor of Chemistry at Rhodes University.
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Form over function? The practical application of the Recognition of Customary Marriages Act 1998 in South Africa
- Authors: Kruuse, Helen
- Date: 2013
- Language: English
- Type: Article , text
- Identifier: http://hdl.handle.net/10962/54094 , vital:26389 , http://journals.co.za/content/ju_jur/2013/1/EJC148455
- Description: The Recognition of Customary Marriages Act 120 of 1998 is a major legislative measure for the development of customary marriages in line with the constitutional principle of equality, specifically for women. The article explores the interactions between this ideal in the Act with empirical observations and the latest judicial decisions concerning its application. It considers various examples of the lack of protection of women in relationships of a customary nature, and it concludes that both the state and courts favour a formal or definitional approach to customary marriage. In considering alternative approaches that could adequately protect vulnerable parties, two conclusions emerge: First, the article recommends a wholesale revision of the South African family law approach from a focus on form to dependency. Second (and as a short-term measure), the article advocates for the putative marriage doctrine to be applied in the customary marriage context to protect many women who are denied access to 'customary marriage' as a form, and as a result, all of the benefits that flow from such marriage.
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Graviton multipoint functions at the AdS boundary
- Authors: Brustein, R , Medved, A J M
- Date: 2013
- Language: English
- Type: text , Article
- Identifier: vital:6819 , http://hdl.handle.net/10962/d1004425
- Description: The gauge-gravity duality can be used to relate connected multipoint graviton functions to connected multipoint correlation functions of the stress tensor of a strongly coupled fluid. Here, we show how to construct the connected graviton functions for a particular kinematic regime that is ideal for discriminating between different gravitational theories, in particular between Einstein theory and its leading-order string theory correction. Our analysis begins with the one-particle irreducible graviton amplitudes in an anti-de Sitter black brane background.We show how these can be used to calculate the connected graviton functions and demonstrate that the two types of amplitudes agree in some cases. It is then asserted on physical grounds that this agreement persists in all cases for both Einstein gravity and its leading-order correction. This outcome implies that the corresponding field-theory correlation functions can be read off directly from the bulk Lagrangian, just as can be done for the ratio of the shear viscosity to the entropy density.
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Obituary: John Mayne English 1922-2013
- Authors: Lewis, Colin A
- Date: 2013
- Language: English
- Type: Article , text
- Identifier: vital:6162 , http://hdl.handle.net/10962/d1004782
- Description: In 1962 John moved south to Johannesburg, but that bustling city held few attractions for him and he moved further south, to the cathedral city of Grahamstown. Grahamstown, with its nineteenth century Gothic cathedral, elegant Georgian buildings, and distinctive grandeur of Rhodes University, St Andrew's College and other buildings designed by Herbert Baker and his colleagues, suited John. He particularly enjoyed the academic, social, artistic and dramatic life of the community, where many older members of society were distinguished old-Africa hands. John thoroughly enjoyed Grahamstown where, in the partnership of Hoskins and English, he made his mark in the restoration and extension of many significant buildings. His addition to the Anglican chapel at Hog's Back is a masterpiece, as is his incorporation of the old fayade into the rebuilding and extension of the Magistrates' Court.
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Prof Nyokong wins NRF Lifetime Achievement Award
- Date: 2013
- Subjects: Nyokong, Tebello
- Language: English
- Type: Article , text
- Identifier: vital:7215 , http://hdl.handle.net/10962/d1006511 , Nyokong, Tebello
- Description: Professor Tebello Nyokong of Rhodes University was presented with the Lifetime Achievement Award at this year’s NRF Awards, held in Port Elizabeth, 2013. She is currently a Distinguished Professor of Chemistry at Rhodes University and holder of the DST-NRF Research Chair in Medicinal Chemistry and Nanotechnology, as well as Director of the DST-Mintek Nanotechnology Innovation Centre focussing on sensors.
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You reap what you sow : regulating marriages and intimate partnerships in a diverse post-apartheid society
- Authors: Kruuse, Helen
- Date: 2013
- Language: English
- Type: Article , text
- Identifier: http://hdl.handle.net/10962/54152 , vital:26396 , https://tinyurl.com/yaughtn2
- Description: South Africa does not have a particularly proud history. Marred by the politics of separate but (un)equal treatment of its people, the country's past political system has had a damaging effect in all spheres, but specifically on that of the family. In the context of relationships, it is fair to say that the apartheid system was replicated in family law, with the Western 'white' monogamous marriage receiving the state's stamp of approval - leaving other relationships (customary, Muslim, homosexual, cohabiting etc) largely out in the cold.
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A quantitative post-release evaluation of biological control of water lettuce, Pistia stratiotes L. (Araceae) by the weevil Neohydronomus affinis Hustache (Coleoptera: Curculionidae) at Cape Recife Nature Reserve, Eastern Cape Province, South Africa
- Authors: Moore, Gareth R , Hill, Martin P
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6839 , http://hdl.handle.net/10962/d1010987 , http://dx.doi.org/10.4001/003.020.0217 , https://orcid.org/0000-0003-0579-5298
- Description: [from the introduction] Water lettuce, Pistia stratiotes L. (Araceae) is recognized as being among the world’s worst aquatic weeds. In its adventive range, the plant forms extensive mats capable of blocking navigation channels, impeding water flow in irrigation and flood control canals, and disrupting hydropower generation (Holm et al. 1977). Dense mats of the weed prevent light penetration into the water column which negatively affects submerged aquatic plant communities, causing a lowering of the oxygen concentration and thereby reducing benthic invertebrate and fish populations (Neuenschwander et al. 2009).
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Cryptic variation in an ecological indicator organism: mitochondrial and nuclear DNA sequence data confirm distinct lineages of Baetis harrisoni Barnard (Ephemeroptera: Baetidae) in southern Africa
- Authors: Pereira-da-Conceicoa, L L , Price, Benjamin W , Barber-James, Helen M
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:7151 , http://hdl.handle.net/10962/d1011855
- Description: Baetis harrisoni Barnard is a mayfly frequently encountered in river studies across Africa, but the external morphological features used for identifying nymphs have been observed to vary subtly between different geographic locations. It has been associated with a wide range of ecological conditions, including pH extremes of pH 2.9–10.0 in polluted waters. We present a molecular study of the genetic variation within B. harrisoni across 21 rivers in its distribution range in southern Africa.
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Evaluation of a service-learning elective as an approach to enhancing the pharmacist's role in health promotion in South Africa
- Authors: Srinivas, Sunitha C , Wrench, Wendy W
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6443 , http://hdl.handle.net/10962/d1006630
- Description: Background. A service-learning (SL) elective offered to final-year pharmacy students was introduced in 2007. The elective demonstrated a holistic approach to creating opportunities for future pharmacists to understand the current needs and future challenges of the burden of disease in developing countries such as South Africa and to foresee their key roles in health promotion. Methods. The 2007 Sasol National Festival of Science and Technology (SciFest) was chosen as the ideal platform to implement this elective. Evaluation of the elective was carried out in association with the Academic Development Centre using a web-based software tool known as the ADC evaluation assistant (ADCEA). The ADCEA consisted of a ‘question bank’ from which the course facilitators selected nine ranked closed questions as well as two open-ended questions. Results. SciFest participation, in the course of the service-learning elective, was acknowledged by students to have prepared them as responsible citizens to undertake health promotion in the public sector healthcare system. Conclusion. Students’ experiences of the learning opportunities provided in the SciFest elective highlight the strengths of this SL programme.
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Graviton n-point functions for UV-complete theories in Anti-de Sitter space
- Authors: Brustein, R , Medved, A J M
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6820 , http://hdl.handle.net/10962/d1004427
- Description: We calculate graviton n-point functions in an anti-de Sitter black brane background for effective gravity theories whose linearized equations of motion have at most two time derivatives. We compare the n-point functions in Einstein gravity to those in theories whose leading correction is quadratic in the Riemann tensor. The comparison is made for any number of gravitons and for all physical graviton modes in a kinematic region for which the leading correction can significantly modify the Einstein result. We find that the n-point functions of Einstein gravity depend on at most a single angle, whereas those of the corrected theories may depend on two angles. For the four-point functions, Einstein gravity exhibits linear dependence on the Mandelstam variable s versus a quadratic dependence on s for the corrected theory.
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In vitro dissolution kinetics of Captopril from microspheres manufactured by solvent evaporation
- Authors: Khamanga, Sandile M , Walker, Roderick B
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6390 , http://hdl.handle.net/10962/d1006311
- Description: The aim of this study was to develop and assess captopril-loaded microspheres in which Methocel and Eudragit RS were used as release-controlling factors and to evaluate captopril (CPT) release using kinetic models. Drug-excipient interactions were evaluated using infrared studies, and the physical appearance was characterized using scanning electron microscopy (SEM). A burst effect was observed during the first stage of dissolution for most batches of microspheres. SEM results reveal that this may be attributed to dissolution of captopril crystals that were present on the surface, embedded in the superficial layer of the matrix materials, trapped near the surface of the microspheres, or that may have diffused rapidly through the porous surface of the capsules. The release data generated during in vitro release studies were fitted to zero-order, first-order, Higuchi, Korsmeyer–Peppas, Kopcha, and Makoid–Banakar models. The release kinetics of captopril from most formulations followed a classical Fickian diffusion mechanism. SEM photographs showed that diffusion took place through pores located in the surface of the microcapsules. The Kopcha model diffusion and erosion terms showed a predominance of diffusion relative to swelling or erosion throughout the entire test period. The drug release mechanism was also confirmed by the Makoid–Banakar and Korsmeyer–Peppas model exponents. This further supports a diffusion–release mechanism for most formulations. The models postulate that the total drug released is a summation of several mechanisms (viz., burst release, relaxation-induced controlled release, and diffusional release). These results also support the potential application of Eudragit/Methocel microspheres as a suitable sustained-release drug delivery system for captopril.
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Prediction of water temperature metrics using spatial modelling in the Eastern and Western Cape, South Africa
- Authors: Rivers-Moore, N A , Mantel, S , Dallas, H F
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:7071 , http://hdl.handle.net/10962/d1003947 , http://www.scielo.org.za/scielo.php?pid=S1816-79502012000200002&script=sci_arttext
- Description: Key aspects of a river's temperature regime are described by magnitudes, timing and durations of thermal events, and frequencies of extreme exceedance events. To understand alterations to thermal regimes, it is necessary to describe thermal time series based on these statistics. Classification of sites based on their thermal metrics, and understanding of spatial patterns of these thermal statistics, provides a powerful approach for comparing study sites against reference sites. Water temperature regime dynamics should be viewed regionally, where regional divisions have an inherent underpinning by an understanding of natural thermal variability. The aim of this research was to link key water temperature metrics to readily-mapped environmental surrogates, and to produce spatial images of temperature metrics: 37 temperature metrics were derived for 12 months of sub-daily water temperatures at 90 sites in the Eastern Cape and Western Cape provinces, South Africa. These metrics were correlated with 16 environmental variables. Correlations enabled development of multiple regression models which facilitated mapping of temperature metrics over the study area. This approach has the potential to be applied at a national scale as more thermal time series are collected nationally. It is argued that the appropriateness of management decisions in rivers can be improved by including guidelines for thermal metrics at a regional scale. Such maps could facilitate incorporation of a temperature component into management guidelines for water resources.
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The use of response surface methodology to evaluate the impact of level 2 SUPAC–IR changes on the in vitro release of metronidazole and ranitidine from a fixed-dose combination tablet
- Authors: King’ori, Loti D , Walker, Roderick B
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6391 , http://hdl.handle.net/10962/d1006313
- Description: The purpose of this study was to evaluate the effect of different levels of disintegrant (croscarmellose sodium, CCS), binder (polyvinylprrolidone K30, PVP–K30), and lubricant (magnesium stearate) on the in vitro release of metronidazole (MTZ) and rantidine (RTD) from a solid oral fixed-dose combination tablet. The excipient levels investigated were Level 2 changes in component and composition described in the Scale-Up and Post Approval Changes for Immediate Release (SUPAC–IR) guidance (1). Batches of tablets (1000 units) were manufactured by wet granulation using a Saral high-shear mixer granulator and a Manesty B3B rotary tablet press. Weight uniformity, friability, and disintegration of all tablets were assessed, and all batches complied with compendial specifications. The amount of drug released (Q) at ten minutes was dependent on the levels of CCS in the formulation, and the effect of PVP–K30 and magnesium stearate was dependent on the levels of CCS. Synergistic interactions between independent variables were observed for the Q10 value for RTD, whereas PVP–K30 and magnesium stearate exhibited an antagonistic effect on the Q10 values for MTZ and RTD. The use of response surface methodology facilitated an investigation into the effect of Level 2 component and composition changes, as described in SUPAC–IR, on the in vitro release of MTZ and RTD from a fixed-dose combination (FDC) solid oral dosage form (SODF).
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