The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore
- Authors: Chiwakata, Maynard Tendai
- Date: 2012
- Subjects: Halocarbons , Cancer -- Treatment , Breast -- Cancer -- Treatment
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3866 , http://hdl.handle.net/10962/d1016129
- Description: Breast cancer is one of the leading causes of death, with mortality rate estimates of 465 000 deaths per annum. It is estimated that 1.3 million women are diagnosed with the disease each year especially in the developing countries. Current chemotherapy relies on the use of high doses of non-specific toxic agents that possess adverse side effects and compromise patient’s compliance and adherence to treatment. Paclitaxel, one of the common drugs used in breast cancer chemotherapy results in sensory and motor neuropathy, whilst hormonal therapy e.g. Herceptin causes severe cardiovascular, gastrointestinal and cutaneous side effects. There has been a demand in developing newer cancer agents that demonstrate selective cytoxicity with minimal effect on normal body tissue. Numerous studies have shown that marine organisms produce a wide range of halogenated compounds that possess cytotoxic properties, and hence can be a source of new drug hits or leads for cancer therapy. Halomon, a polyhalogenated monoterpene from Portieria hornemannii, displayed interesting activity against brain, renal and lung cancer tumours with selective/differential cytotoxicity. This inspired us to focus our project on halogenated monoterpenes isolated from the same Rhodophyta class as P. hornemannii but with particular attention to Plocamium species. Several metabolites have been isolated from P. cornutum, P. corallorhiza and P. suhrii that possess interesting cytotoxicities against a breast cancer cell line (MCF7) and an oesophageal cancer line (WHCO1). The aim of the project was therefore centred at isolating target compounds for preliminary structure-activity studies against a breast cancer cell line, and use this information to synthesize a series of analogues that are more stable than the natural products and yet as active using a fragment-based type approach to map out pharmacophoric elements. Five metabolites were isolated from P. cornutum and five from P. corallorhiza. Cell-based assays were conducted using an MTT assay kit against MCF7 and MDA-MB-231 breast cancer cell lines and (1E,3E,5S,6R)-1,5,6-trichloro-2-(dichloromethyl)-6-methylocta-1,3,7-triene, isolated from P. cornutum was the most active with IC50 values of 3.0 μM and 6.15 μM respectively. Introduction of a terminal aromatic ring to enhance stability, together with varying substituents (H, CH3, CF3, Br, CN, CHO, CHCl2) on position 7 of the molecule, gave rise to a series of cinnamate ester derivatives inspired by (1E,3E,5S,6R)-1,5,6-trichloro-2-(dichloromethyl)-6-methylocta-1,3,7-triene. The analogues were synthesized from their benzaldehyde precursors via Aldol condensation, esterification and Wittig reactions. Their carboxylic acid counterparts were synthesized by hydrolysis of the parent esters in an attempt to promote water solubilities of the analogues. Biological activity assays were then conducted with the cinnamate analogues against the MDA-MB-231 breast cancer cell line using an MTT assay kit. Ester derivatives with -CHO and -CHCl2 functionalities had IC50 values of 43.45 μM and 100.01 μM respectively whilst the other ester derivatives were inactive. It was concluded that either an aldehyde (-CHO) or gem-dichlorides (-CHCl2) is specifically required for cytotoxic activity to be observed. None of the carboxylic acids were active which could have been due to failure of the compounds to enter the breast cancer cells and reach the target site because of their polar nature. Compounds with -CHO and -CHCl2 functionalities were therefore selected for future SARs studies.
- Full Text:
- Date Issued: 2012
- Authors: Chiwakata, Maynard Tendai
- Date: 2012
- Subjects: Halocarbons , Cancer -- Treatment , Breast -- Cancer -- Treatment
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3866 , http://hdl.handle.net/10962/d1016129
- Description: Breast cancer is one of the leading causes of death, with mortality rate estimates of 465 000 deaths per annum. It is estimated that 1.3 million women are diagnosed with the disease each year especially in the developing countries. Current chemotherapy relies on the use of high doses of non-specific toxic agents that possess adverse side effects and compromise patient’s compliance and adherence to treatment. Paclitaxel, one of the common drugs used in breast cancer chemotherapy results in sensory and motor neuropathy, whilst hormonal therapy e.g. Herceptin causes severe cardiovascular, gastrointestinal and cutaneous side effects. There has been a demand in developing newer cancer agents that demonstrate selective cytoxicity with minimal effect on normal body tissue. Numerous studies have shown that marine organisms produce a wide range of halogenated compounds that possess cytotoxic properties, and hence can be a source of new drug hits or leads for cancer therapy. Halomon, a polyhalogenated monoterpene from Portieria hornemannii, displayed interesting activity against brain, renal and lung cancer tumours with selective/differential cytotoxicity. This inspired us to focus our project on halogenated monoterpenes isolated from the same Rhodophyta class as P. hornemannii but with particular attention to Plocamium species. Several metabolites have been isolated from P. cornutum, P. corallorhiza and P. suhrii that possess interesting cytotoxicities against a breast cancer cell line (MCF7) and an oesophageal cancer line (WHCO1). The aim of the project was therefore centred at isolating target compounds for preliminary structure-activity studies against a breast cancer cell line, and use this information to synthesize a series of analogues that are more stable than the natural products and yet as active using a fragment-based type approach to map out pharmacophoric elements. Five metabolites were isolated from P. cornutum and five from P. corallorhiza. Cell-based assays were conducted using an MTT assay kit against MCF7 and MDA-MB-231 breast cancer cell lines and (1E,3E,5S,6R)-1,5,6-trichloro-2-(dichloromethyl)-6-methylocta-1,3,7-triene, isolated from P. cornutum was the most active with IC50 values of 3.0 μM and 6.15 μM respectively. Introduction of a terminal aromatic ring to enhance stability, together with varying substituents (H, CH3, CF3, Br, CN, CHO, CHCl2) on position 7 of the molecule, gave rise to a series of cinnamate ester derivatives inspired by (1E,3E,5S,6R)-1,5,6-trichloro-2-(dichloromethyl)-6-methylocta-1,3,7-triene. The analogues were synthesized from their benzaldehyde precursors via Aldol condensation, esterification and Wittig reactions. Their carboxylic acid counterparts were synthesized by hydrolysis of the parent esters in an attempt to promote water solubilities of the analogues. Biological activity assays were then conducted with the cinnamate analogues against the MDA-MB-231 breast cancer cell line using an MTT assay kit. Ester derivatives with -CHO and -CHCl2 functionalities had IC50 values of 43.45 μM and 100.01 μM respectively whilst the other ester derivatives were inactive. It was concluded that either an aldehyde (-CHO) or gem-dichlorides (-CHCl2) is specifically required for cytotoxic activity to be observed. None of the carboxylic acids were active which could have been due to failure of the compounds to enter the breast cancer cells and reach the target site because of their polar nature. Compounds with -CHO and -CHCl2 functionalities were therefore selected for future SARs studies.
- Full Text:
- Date Issued: 2012
The synthesis of fructooligosaccharides by the fructofuranosidase FopAp from Aspergillus niger
- Pindura, Mitchell Kingsley Chido
- Authors: Pindura, Mitchell Kingsley Chido
- Date: 2012
- Subjects: Aspergillus niger , Oligosaccharides
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4158 , http://hdl.handle.net/10962/d1018267
- Description: Fructooligosaccharides (FOS) are short-chain fructans with a terminal glucose moiety and are found naturally in many plant species. Besides their wide use as an alternative sweetener in food and beverage industry, FOS have shown great potential as neutraceuticals against diabetes, colon cancer and bowel disease. The uses of FOS are dependent on the degree of polymerisation that they exhibit. β-fructofuranosidase (FFase) and fructosyltransferase (FTase) enzymes are capable of synthesing FOS from carbohydrate raw materials such as chicory and sugar beet. The aim of this study was to investigate the synthesis of FOS of a pre-defined chain length, from sucrose, by the enzyme FopAp; a β-fructofuranosidase from Aspergillus niger. ATCC 20611. The crude enzyme FopAp was successfully purified, with a yield of 78.20 %, by ammonium sulphate precipitation and anion exchange chromatography. Two protein fractions, named FA and FB were shown to exhibit FFase activity. SDS PAGE analysis revealed two proteins with molecular weights of 112 kDa and 78 kDa, which were identified as a FFase and a hydrolase. Temperature and pH optima of 20 ºC and 9, respectively, were observed for the transfructosylation activity in the FFase. The purified FFase exhibited a half life of 1.5 hrs under optimal conditions. Substrate kinetic studies indicated a high hydrolytic activity at low sucrose concentrations, with Vmax and Km of 1.25 μmol/ml/min and 3.28 mM, respectively. Analysis by response surface methodology identified temperature and pH to be significant factors for the production of kestose and nystose, at a 95 % level of confidence. These findings were confirmed by neural networks constructed to identify optimal conditions of FOS synthesis.FOS synthesis was found to be optimal between pH 6 and pH 9 at 25 ºC. The factor of reaction time was found to be insignificant within the selected experimental constraints, for both FOS species. The findings of this investigation are very important as the foundations of a commercially viable synthetic process for the production of FOS.
- Full Text:
- Date Issued: 2012
- Authors: Pindura, Mitchell Kingsley Chido
- Date: 2012
- Subjects: Aspergillus niger , Oligosaccharides
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4158 , http://hdl.handle.net/10962/d1018267
- Description: Fructooligosaccharides (FOS) are short-chain fructans with a terminal glucose moiety and are found naturally in many plant species. Besides their wide use as an alternative sweetener in food and beverage industry, FOS have shown great potential as neutraceuticals against diabetes, colon cancer and bowel disease. The uses of FOS are dependent on the degree of polymerisation that they exhibit. β-fructofuranosidase (FFase) and fructosyltransferase (FTase) enzymes are capable of synthesing FOS from carbohydrate raw materials such as chicory and sugar beet. The aim of this study was to investigate the synthesis of FOS of a pre-defined chain length, from sucrose, by the enzyme FopAp; a β-fructofuranosidase from Aspergillus niger. ATCC 20611. The crude enzyme FopAp was successfully purified, with a yield of 78.20 %, by ammonium sulphate precipitation and anion exchange chromatography. Two protein fractions, named FA and FB were shown to exhibit FFase activity. SDS PAGE analysis revealed two proteins with molecular weights of 112 kDa and 78 kDa, which were identified as a FFase and a hydrolase. Temperature and pH optima of 20 ºC and 9, respectively, were observed for the transfructosylation activity in the FFase. The purified FFase exhibited a half life of 1.5 hrs under optimal conditions. Substrate kinetic studies indicated a high hydrolytic activity at low sucrose concentrations, with Vmax and Km of 1.25 μmol/ml/min and 3.28 mM, respectively. Analysis by response surface methodology identified temperature and pH to be significant factors for the production of kestose and nystose, at a 95 % level of confidence. These findings were confirmed by neural networks constructed to identify optimal conditions of FOS synthesis.FOS synthesis was found to be optimal between pH 6 and pH 9 at 25 ºC. The factor of reaction time was found to be insignificant within the selected experimental constraints, for both FOS species. The findings of this investigation are very important as the foundations of a commercially viable synthetic process for the production of FOS.
- Full Text:
- Date Issued: 2012
The synthesis of α-alkoxy and α-aminostannanes as precursors to Novel Chromium Fischer Carbenes
- Authors: Meyer, Annalene
- Date: 2012
- Subjects: Alkoxides , Organometallic compounds , Carbenes (Methylene compounds) , Chromium , Molybdenum , Tungsten , Organolithium compounds
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4371 , http://hdl.handle.net/10962/d1005036 , Alkoxides , Organometallic compounds , Carbenes (Methylene compounds) , Chromium , Molybdenum , Tungsten , Organolithium compounds
- Description: The present study involves the use of main group organometallics: organostannanes and organolithiums as precursors to chromium Fischer carbene complexes. Fischer carbenes are well stabilized by the π‐donor substituents such as alkoxy and amino groups and low oxidation state metals such as Group 6 (Chromium, Molybdenum or Tungsten). Carbenes are an important intermediate in the synthesis of a range of compounds through cyclopropanations, insertions, coupling and photochemical reactions. Synthesis and successful characterisation of three α‐alkoxystannanes was achieved via nucleophilic addition of tributylstannyllithium to the respective aldehydes, followed by an immediate MOM protection of the resulting alcohol. Six α‐aminostanannes were synthesised, consisting of N‐BOC, N‐acetyl and N‐ethyl derivatives of pyrrolidine and piperidine, via α‐lithiation and subsequent tinlithium transmetallation in the presence of TMEDA. The ¹³C NMR analysis highlighted an interesting phenomenon of tin‐carbon coupling that revealed unique structural information of both types of stannanes. DFT analysis was completed on the series of stannanes; a predicted frequency analysis was obtained which complemented the experimental Infra‐red data in elucidation of the compounds. The α‐alkoxy and α‐aminostannanes provided stable precursors to the organolithiums required for the synthesis of the novel Fischer chromium carbenes. The organolithiums were obtained via tinlithium exchange at low temperatures, followed by the addition of chromium hexacarbonyl to form the acylpentacarbonyl‐chromate salt. Alkylation of this intermediate using a Meerwein salt, Me₃OBF₄, gave rise to the novel Fischer chromium carbene complexes. Fischer chromium carbenes derived from the two isomeric butyl and isobutyl stannanes and the two N‐ethyl α‐aminostannanes were successfully synthesised. The difficulty encountered in the purification of the Fischer carbene complexes hindered the full characterisation, due to the presence of a by‐product, tetrabutyltin.
- Full Text:
- Date Issued: 2012
- Authors: Meyer, Annalene
- Date: 2012
- Subjects: Alkoxides , Organometallic compounds , Carbenes (Methylene compounds) , Chromium , Molybdenum , Tungsten , Organolithium compounds
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4371 , http://hdl.handle.net/10962/d1005036 , Alkoxides , Organometallic compounds , Carbenes (Methylene compounds) , Chromium , Molybdenum , Tungsten , Organolithium compounds
- Description: The present study involves the use of main group organometallics: organostannanes and organolithiums as precursors to chromium Fischer carbene complexes. Fischer carbenes are well stabilized by the π‐donor substituents such as alkoxy and amino groups and low oxidation state metals such as Group 6 (Chromium, Molybdenum or Tungsten). Carbenes are an important intermediate in the synthesis of a range of compounds through cyclopropanations, insertions, coupling and photochemical reactions. Synthesis and successful characterisation of three α‐alkoxystannanes was achieved via nucleophilic addition of tributylstannyllithium to the respective aldehydes, followed by an immediate MOM protection of the resulting alcohol. Six α‐aminostanannes were synthesised, consisting of N‐BOC, N‐acetyl and N‐ethyl derivatives of pyrrolidine and piperidine, via α‐lithiation and subsequent tinlithium transmetallation in the presence of TMEDA. The ¹³C NMR analysis highlighted an interesting phenomenon of tin‐carbon coupling that revealed unique structural information of both types of stannanes. DFT analysis was completed on the series of stannanes; a predicted frequency analysis was obtained which complemented the experimental Infra‐red data in elucidation of the compounds. The α‐alkoxy and α‐aminostannanes provided stable precursors to the organolithiums required for the synthesis of the novel Fischer chromium carbenes. The organolithiums were obtained via tinlithium exchange at low temperatures, followed by the addition of chromium hexacarbonyl to form the acylpentacarbonyl‐chromate salt. Alkylation of this intermediate using a Meerwein salt, Me₃OBF₄, gave rise to the novel Fischer chromium carbene complexes. Fischer chromium carbenes derived from the two isomeric butyl and isobutyl stannanes and the two N‐ethyl α‐aminostannanes were successfully synthesised. The difficulty encountered in the purification of the Fischer carbene complexes hindered the full characterisation, due to the presence of a by‐product, tetrabutyltin.
- Full Text:
- Date Issued: 2012
The synthesis, photophysical and dielectric properties of ball-type dinuclear zinc phthalocyanine
- Canlıca, Mevlüde, Altındal, Ahmet, Nyokong, Tebello
- Authors: Canlıca, Mevlüde , Altındal, Ahmet , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243532 , vital:51161 , xlink:href="https://doi.org/10.1142/S1088424612500836"
- Description: The synthesis of ball-type dinuclear Zn(II) phthalocyanine containing four 4,4′-(9H-fluorene-9,9-diyl)diphenol substituents at the non-peripheral position is presented. The structure of the synthesized compound was characterized using elemental analyzes, and UV-vis, FT-IR, 1H NMR and mass spectroscopies. The ΦF value was 0.16 and ΦT value was 0.72. The complex showed reasonably long triplet lifetimes with τT 7210 μs in DMSO. The frequency and temperature dependence of the dielectric properties of ZnPc were also investigated in the frequency range of 40–105 Hz and in the temperature range of 300–440 °K. It has been observed that both dielectric constant ε′ and dielectric loss ε″ decrease with the rise in frequency as they increase with the rise in temperature. The decrease in ε′ with increasing frequency is attributed to the fact that as the frequency increases, the polarizability contribution from orientation sources decreases and finally disappears.
- Full Text:
- Date Issued: 2012
- Authors: Canlıca, Mevlüde , Altındal, Ahmet , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243532 , vital:51161 , xlink:href="https://doi.org/10.1142/S1088424612500836"
- Description: The synthesis of ball-type dinuclear Zn(II) phthalocyanine containing four 4,4′-(9H-fluorene-9,9-diyl)diphenol substituents at the non-peripheral position is presented. The structure of the synthesized compound was characterized using elemental analyzes, and UV-vis, FT-IR, 1H NMR and mass spectroscopies. The ΦF value was 0.16 and ΦT value was 0.72. The complex showed reasonably long triplet lifetimes with τT 7210 μs in DMSO. The frequency and temperature dependence of the dielectric properties of ZnPc were also investigated in the frequency range of 40–105 Hz and in the temperature range of 300–440 °K. It has been observed that both dielectric constant ε′ and dielectric loss ε″ decrease with the rise in frequency as they increase with the rise in temperature. The decrease in ε′ with increasing frequency is attributed to the fact that as the frequency increases, the polarizability contribution from orientation sources decreases and finally disappears.
- Full Text:
- Date Issued: 2012
The treatment of brewery effluent using an integrated high rate algal ponding system
- Authors: Cilliers, Anneke
- Date: 2012
- Subjects: Water -- Purification -- South Africa , Algae -- Biotechnology , Algae culture , Algae -- Economic aspects
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5331 , http://hdl.handle.net/10962/d1005177 , Water -- Purification -- South Africa , Algae -- Biotechnology , Algae culture , Algae -- Economic aspects
- Description: The application of high rate algal ponds (HRAP) in the treatment of brewery effluent that met the South African Department of Water Affairs and Forestry's (DWAF) general limits for discharge into a natural water resource of 1998 were tested during a lO-month baseline phase, followed by an 11-month optimization phase. The objective of the baseline phase was to monitor the seasonal performance of HRAPs. The hydraulic retention time (HRT) fluctuated between 11.16 d and 12.00 d in HRAPs. The chemical oxygen demand (COD) increased from 130.12 ± 6.94 mg/L (post-AD), to 171.21 ± 7.99 mg/L (post-HRAP) . The presence of algal cells and evaporation contributed towards an increase in post-HRAP COD. The ammonia (NH₄-N) concentration decreased from 46.59 ± 2.47 mg/L (post-AD), to 1.08 ± 0.12 mg/L (post-HRAP). The nitrite (NO₂- N) concentration remained below 1.00 mg/L in post-pilot plant AD, post-PFP and post-HRAP effluent. The phosphate (PO₄-P) concentration decreased from 29.81 ± 1.39 mg/L (post-AD) to 17.30 ± 1.16 mg/L PO₄-P. The objective of the optimization phase was to manipulate the HRT to achieve the maximum treatment rate that met the DWAF general limits for discharge into a natural water resource of 1998. Nitrogen (as NH₄-N, NO₃-N, NO₂-N) removal efficiency was used as an indicator of nutrient removal success. HRT was influenced by season. The optimal HRT for autumn was 4.30 d at a temperature of 20.53ºC in HRAP A2 (heated) and 18.96ºC in HRAP B2 (ambient). The optimal HRT for summer was 2.74 d at 29.90ºC in HRAP A2 (heated) and 26.36ºC in HRAP B2 (ambient). The COD decreased from 152.33 ± 4.85 mg/L (post-AD) to 95 .00 ± 3.75 mg/L (post-HRAP A2), and to 100.82 ± 5.93 mg/L (post-HRAP B2). The incoming NH₄-N concentration decreased from 42.53 ± 1.38 mg/ L (post-AD), to 1.70 ± 0.81 mg/ L (post-HRAP) . The nitrate (NO₃-N) concentration post-HRAP was 12 - 14 mg/L. The main methods for NH₄-N removal were probably NH₄-N volatilization through algal uptake. HRAPs were able to lower nitrogen and phosphorous concentrations to within the DWAF limits under normal operating conditions. It is recommended that HRAP treated brewery wastewater be used for irrigation after salt removal, or alternatively, for groundwater recharge . Regulatory exemptions would be required for higher than permitted COD and EC concentrations to enable these actions.
- Full Text:
- Date Issued: 2012
- Authors: Cilliers, Anneke
- Date: 2012
- Subjects: Water -- Purification -- South Africa , Algae -- Biotechnology , Algae culture , Algae -- Economic aspects
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5331 , http://hdl.handle.net/10962/d1005177 , Water -- Purification -- South Africa , Algae -- Biotechnology , Algae culture , Algae -- Economic aspects
- Description: The application of high rate algal ponds (HRAP) in the treatment of brewery effluent that met the South African Department of Water Affairs and Forestry's (DWAF) general limits for discharge into a natural water resource of 1998 were tested during a lO-month baseline phase, followed by an 11-month optimization phase. The objective of the baseline phase was to monitor the seasonal performance of HRAPs. The hydraulic retention time (HRT) fluctuated between 11.16 d and 12.00 d in HRAPs. The chemical oxygen demand (COD) increased from 130.12 ± 6.94 mg/L (post-AD), to 171.21 ± 7.99 mg/L (post-HRAP) . The presence of algal cells and evaporation contributed towards an increase in post-HRAP COD. The ammonia (NH₄-N) concentration decreased from 46.59 ± 2.47 mg/L (post-AD), to 1.08 ± 0.12 mg/L (post-HRAP). The nitrite (NO₂- N) concentration remained below 1.00 mg/L in post-pilot plant AD, post-PFP and post-HRAP effluent. The phosphate (PO₄-P) concentration decreased from 29.81 ± 1.39 mg/L (post-AD) to 17.30 ± 1.16 mg/L PO₄-P. The objective of the optimization phase was to manipulate the HRT to achieve the maximum treatment rate that met the DWAF general limits for discharge into a natural water resource of 1998. Nitrogen (as NH₄-N, NO₃-N, NO₂-N) removal efficiency was used as an indicator of nutrient removal success. HRT was influenced by season. The optimal HRT for autumn was 4.30 d at a temperature of 20.53ºC in HRAP A2 (heated) and 18.96ºC in HRAP B2 (ambient). The optimal HRT for summer was 2.74 d at 29.90ºC in HRAP A2 (heated) and 26.36ºC in HRAP B2 (ambient). The COD decreased from 152.33 ± 4.85 mg/L (post-AD) to 95 .00 ± 3.75 mg/L (post-HRAP A2), and to 100.82 ± 5.93 mg/L (post-HRAP B2). The incoming NH₄-N concentration decreased from 42.53 ± 1.38 mg/ L (post-AD), to 1.70 ± 0.81 mg/ L (post-HRAP) . The nitrate (NO₃-N) concentration post-HRAP was 12 - 14 mg/L. The main methods for NH₄-N removal were probably NH₄-N volatilization through algal uptake. HRAPs were able to lower nitrogen and phosphorous concentrations to within the DWAF limits under normal operating conditions. It is recommended that HRAP treated brewery wastewater be used for irrigation after salt removal, or alternatively, for groundwater recharge . Regulatory exemptions would be required for higher than permitted COD and EC concentrations to enable these actions.
- Full Text:
- Date Issued: 2012
The trophic ecology of parrotfish of Zanzibar application of stable isotope analysis
- Plass-Johnson, Jeremiah Grahm
- Authors: Plass-Johnson, Jeremiah Grahm
- Date: 2012
- Subjects: Parrotfishes -- Tanzania -- Zanzibar , Parrotfishes , Parrotfishes -- Ecology -- Tanzania -- Zanzibar , Parrotfishes -- Behavior -- Tanzania -- Zanzibar , Parrotfishes -- Food -- Tanzania -- Zanzibar , Scleractinia -- Tanzania -- Zanzibar , Algae -- Tanzania -- Zanzibar , Coral reefs and islands -- Tanzania -- Zanzibar , Coral reef fishes -- Tanzania -- Zanzibar , Stable isotopes
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5789 , http://hdl.handle.net/10962/d1005477 , Parrotfishes -- Tanzania -- Zanzibar , Parrotfishes , Parrotfishes -- Ecology -- Tanzania -- Zanzibar , Parrotfishes -- Behavior -- Tanzania -- Zanzibar , Parrotfishes -- Food -- Tanzania -- Zanzibar , Scleractinia -- Tanzania -- Zanzibar , Algae -- Tanzania -- Zanzibar , Coral reefs and islands -- Tanzania -- Zanzibar , Coral reef fishes -- Tanzania -- Zanzibar , Stable isotopes
- Description: Parrotfish are a critical component of the herbivore functional group on tropical coral reefs around the world because they mediate competition that occurs between algae and scleractinian corals. Also, because of their feeding technique, which consists of rasping at the substratum with their beak-like teeth, they play an important role in carbonate turnover and the clearing of reef surface area for the settlement of new sessile organisms. Because of these roles, parrotfishes are an important structuring component of coral reef communities. However, individual species can play different roles depending on their physiology, behaviour and ecology. Despite the possible ecological differences that may exist amongst species, specific roles of the fishes remain unclear as the group is most often studied at higher community levels. This thesis applied stable isotope analysis to differing levels of organisation within a parrotfish community to help elucidate their trophic ecology on coral reefs in Zanzibar. Firstly, blood and muscle tissues were compared to identify differences in their isotope signatures. In other organisms, blood turns over faster than muscle tissue so that muscle tissue represents the diet as integrated over a longer period of time. In most species of parrotfish the blood and muscle δ¹³C signatures were not found to be significantly different, but the δ¹⁵N signatures were significantly different between tissues. This indicated that the δ¹³C signature of both tissues would reveal similar dietary information. Conversely, differences in the δ¹⁵N signature indicated that the nitrogen relationship between tissues was more complicated. Secondly, spatial variability in parrotfish, coral, detritus and macroalgae isotope signatures was assessed at different scales. In macroalgae and coral tissues (zooxanthellae and polyp treated separately), the δ¹³C signatures were shown to differ with depth, presumably because of changes in photosynthetic processes related to depth-associated changes in light. While δ¹⁵N signatures were not affected by depth, all organisms showed enrichment at the Nyange reef, the closest reef to the capital of Zanzibar, Stone Town, presumably reflecting the effects of sewage outfall. These results show that processes that impact the δ¹⁵N signatures of primary producers (macroalgae and zooxanthellae) can be traced to higher trophic levels (coral polyps and fish). Lastly, δ¹³C and δ¹⁵N signatures were used to identify ontogenetic dietary changes in multiple species of parrotfish. Four of the species showed stages that varied from the diets that are normally assumed on the basis of their dentition and feeding technique. This indicates that functional roles based on taxonomy or morphology may fail to include possible ontogenetic dietary changes, and may also fail to elucidate the full impact a species could have on coral reef communities. The conclusions from these studies indicate that the species-specific ecological role of parrotfish in coral reef communities can be complex within and between species, and may differ amongst reefs. In light of the natural and anthropogenic pressures that affect coral reef systems, management decisions based on a more complete understanding of the role of these fish in coral reef communities will help decisions that maintain resilience in these fragile systems.
- Full Text:
- Date Issued: 2012
- Authors: Plass-Johnson, Jeremiah Grahm
- Date: 2012
- Subjects: Parrotfishes -- Tanzania -- Zanzibar , Parrotfishes , Parrotfishes -- Ecology -- Tanzania -- Zanzibar , Parrotfishes -- Behavior -- Tanzania -- Zanzibar , Parrotfishes -- Food -- Tanzania -- Zanzibar , Scleractinia -- Tanzania -- Zanzibar , Algae -- Tanzania -- Zanzibar , Coral reefs and islands -- Tanzania -- Zanzibar , Coral reef fishes -- Tanzania -- Zanzibar , Stable isotopes
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5789 , http://hdl.handle.net/10962/d1005477 , Parrotfishes -- Tanzania -- Zanzibar , Parrotfishes , Parrotfishes -- Ecology -- Tanzania -- Zanzibar , Parrotfishes -- Behavior -- Tanzania -- Zanzibar , Parrotfishes -- Food -- Tanzania -- Zanzibar , Scleractinia -- Tanzania -- Zanzibar , Algae -- Tanzania -- Zanzibar , Coral reefs and islands -- Tanzania -- Zanzibar , Coral reef fishes -- Tanzania -- Zanzibar , Stable isotopes
- Description: Parrotfish are a critical component of the herbivore functional group on tropical coral reefs around the world because they mediate competition that occurs between algae and scleractinian corals. Also, because of their feeding technique, which consists of rasping at the substratum with their beak-like teeth, they play an important role in carbonate turnover and the clearing of reef surface area for the settlement of new sessile organisms. Because of these roles, parrotfishes are an important structuring component of coral reef communities. However, individual species can play different roles depending on their physiology, behaviour and ecology. Despite the possible ecological differences that may exist amongst species, specific roles of the fishes remain unclear as the group is most often studied at higher community levels. This thesis applied stable isotope analysis to differing levels of organisation within a parrotfish community to help elucidate their trophic ecology on coral reefs in Zanzibar. Firstly, blood and muscle tissues were compared to identify differences in their isotope signatures. In other organisms, blood turns over faster than muscle tissue so that muscle tissue represents the diet as integrated over a longer period of time. In most species of parrotfish the blood and muscle δ¹³C signatures were not found to be significantly different, but the δ¹⁵N signatures were significantly different between tissues. This indicated that the δ¹³C signature of both tissues would reveal similar dietary information. Conversely, differences in the δ¹⁵N signature indicated that the nitrogen relationship between tissues was more complicated. Secondly, spatial variability in parrotfish, coral, detritus and macroalgae isotope signatures was assessed at different scales. In macroalgae and coral tissues (zooxanthellae and polyp treated separately), the δ¹³C signatures were shown to differ with depth, presumably because of changes in photosynthetic processes related to depth-associated changes in light. While δ¹⁵N signatures were not affected by depth, all organisms showed enrichment at the Nyange reef, the closest reef to the capital of Zanzibar, Stone Town, presumably reflecting the effects of sewage outfall. These results show that processes that impact the δ¹⁵N signatures of primary producers (macroalgae and zooxanthellae) can be traced to higher trophic levels (coral polyps and fish). Lastly, δ¹³C and δ¹⁵N signatures were used to identify ontogenetic dietary changes in multiple species of parrotfish. Four of the species showed stages that varied from the diets that are normally assumed on the basis of their dentition and feeding technique. This indicates that functional roles based on taxonomy or morphology may fail to include possible ontogenetic dietary changes, and may also fail to elucidate the full impact a species could have on coral reef communities. The conclusions from these studies indicate that the species-specific ecological role of parrotfish in coral reef communities can be complex within and between species, and may differ amongst reefs. In light of the natural and anthropogenic pressures that affect coral reef systems, management decisions based on a more complete understanding of the role of these fish in coral reef communities will help decisions that maintain resilience in these fragile systems.
- Full Text:
- Date Issued: 2012
The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients
- Kasongo, Kasongo W, Müller, Rainer H, Walker, Roderick B
- Authors: Kasongo, Kasongo W , Müller, Rainer H , Walker, Roderick B
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184087 , vital:44170 , xlink:href="https://doi.org/10.3109/10837450.2010.542163"
- Description: A major obstacle to the application of nanostructured lipid carriers (NLCs) as carriers for hydrophilic drugs is the limited loading capacity (LC) and encapsulation efficiency (EE) of NLCs for these molecules. The purpose of this research was to design and implement a strategy to enhance the LC and EE of NLCs for the hydrophilic drug, didanosine (DDI). DDI was dispersed in Transcutol® HP and the particle size of DDI in the liquid lipid was reduced gradually using hot high pressure homogenization (HPH). The product obtained thereafter was added to Precirol® ATO 5 and the hot mixture was immediately dried using liquid nitrogen. The dried materials were then ground and passed through a 200 μm sieve and the solid lipid particles were dispersed in a surfactant solution and subsequently used to manufacture DDI-loaded NLCs using cold HPH. The LC and EE of NLCs for DDI manufactured using the new strategy were 3.39 ± 0.63% and 51.58 ± 1.31%, respectively, compared to 0.079 ± 0.001% and 32.45 ± 0.08%, respectively, obtained when DDI-loaded NLCs were produced using conventional hot HPH. The enhanced LC and EE for DDI make NLCs a potential technology for the oral administration of DDI to paediatric patients.
- Full Text:
- Date Issued: 2012
- Authors: Kasongo, Kasongo W , Müller, Rainer H , Walker, Roderick B
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184087 , vital:44170 , xlink:href="https://doi.org/10.3109/10837450.2010.542163"
- Description: A major obstacle to the application of nanostructured lipid carriers (NLCs) as carriers for hydrophilic drugs is the limited loading capacity (LC) and encapsulation efficiency (EE) of NLCs for these molecules. The purpose of this research was to design and implement a strategy to enhance the LC and EE of NLCs for the hydrophilic drug, didanosine (DDI). DDI was dispersed in Transcutol® HP and the particle size of DDI in the liquid lipid was reduced gradually using hot high pressure homogenization (HPH). The product obtained thereafter was added to Precirol® ATO 5 and the hot mixture was immediately dried using liquid nitrogen. The dried materials were then ground and passed through a 200 μm sieve and the solid lipid particles were dispersed in a surfactant solution and subsequently used to manufacture DDI-loaded NLCs using cold HPH. The LC and EE of NLCs for DDI manufactured using the new strategy were 3.39 ± 0.63% and 51.58 ± 1.31%, respectively, compared to 0.079 ± 0.001% and 32.45 ± 0.08%, respectively, obtained when DDI-loaded NLCs were produced using conventional hot HPH. The enhanced LC and EE for DDI make NLCs a potential technology for the oral administration of DDI to paediatric patients.
- Full Text:
- Date Issued: 2012
The use of Internet-based information sources by postgraduate students: a survey of three universities in the Eastern Cape, South Africa
- Authors: Mbasera, Sarlomie Farisai
- Date: 2012
- Language: English
- Type: Thesis , Masters , M Bibl
- Identifier: http://hdl.handle.net/10353/976 , vital:26514
- Description: The study investigated the use of Internet-based information sources by postgraduate students at three universities in the Eastern Cape province of South Africa. The main aim of the study was to determine the factors that affect the use of Internet-based information sources by postgraduate students. The study sought to fulfil the following objectives: to determine factors which affect the use of Internet-based information sources by postgraduate students at the three universities in the Eastern Cape, South Africa; to establish the Internet-based information sources available among universities in Eastern Cape; to identify the pattern of postgraduate students’ use of Internet-based information sources; to find out the level of postgraduate satisfaction with Internet-based information sources available for their information needs, and to suggest ways of stimulating the use of Internet-based information sources by postgraduate students at universities in the Eastern Cape, South Africa. A review of the literature revealed a growing reliance on electronic resources by higher education institutions worldwide to suffice the information needs of academic researchers and that usage of these is influenced by various factors. The factors identified in the reviewed literature as affecting the use of Internet-based information sources among students include: academic discipline affiliation, age, level of study, gender, information and communications technology (ICT) literacy, institutional support, relevance of available information resources, accessibility, marketing and publicity of information sources available, and training. The researcher employed a survey research methodology to achieve the study objectives, through data collection on three fronts. Firstly to investigate the factors hat affect the use of Internet-based information sources from the perspectives of postgraduate students, self-administered questionnaires were distributed to a sample of 200 study participants obtained using quota sampling of the population of students from the three universities. A response rate of 66.5% was achieved. Secondly, data on the organisational factors influencing the use of Internet-based information sources were obtained by conducting semi-structured interviews with selected librarians at the three universities. Lastly, documentary analysis was also used to corroborate data obtained from the survey with postgraduate study participants, as well as from interviews with selected librarians. The findings include that the use of Internet-based information sources is increasingly becoming important for postgraduate students at the selected universities in the Eastern Cape, South Africa. Postgraduate students believe that Internet-based information sources are useful in their academic work. There was moderate use of subscription e-databases and e-journals. Level of study and age were found to affect the use of Internet-based information sources, with older, Masters and PhD students utilising e-databases and e-journals more frequently. Postgraduate students predominantly use search engines to gain access to Internet-based information sources, while Online Public Access Catalogues (OPACs) and library websites were unpopular gateways to Internet-based information sources. Universities in the Eastern Cape were found to be supportive of the use of Internet-based information sources with budgets of libraries and future plans tipped in favour of electronic resource provision. From the findings of the study the key recommendations suggested for improving the use of Internet-based information sources by postgraduate students in the Eastern Cape province of South Africa, include that Information literacy training programmes at the three universities may be tailor-made to cater for the information needs of postgraduate students at varying levels and academic disciplines of study. It was also recommended that the universities incorporate the use of federated searching and searchable journals management software on their library websites, in order to increase the visibility of Internet-based information sources among postgraduate students.
- Full Text:
- Date Issued: 2012
- Authors: Mbasera, Sarlomie Farisai
- Date: 2012
- Language: English
- Type: Thesis , Masters , M Bibl
- Identifier: http://hdl.handle.net/10353/976 , vital:26514
- Description: The study investigated the use of Internet-based information sources by postgraduate students at three universities in the Eastern Cape province of South Africa. The main aim of the study was to determine the factors that affect the use of Internet-based information sources by postgraduate students. The study sought to fulfil the following objectives: to determine factors which affect the use of Internet-based information sources by postgraduate students at the three universities in the Eastern Cape, South Africa; to establish the Internet-based information sources available among universities in Eastern Cape; to identify the pattern of postgraduate students’ use of Internet-based information sources; to find out the level of postgraduate satisfaction with Internet-based information sources available for their information needs, and to suggest ways of stimulating the use of Internet-based information sources by postgraduate students at universities in the Eastern Cape, South Africa. A review of the literature revealed a growing reliance on electronic resources by higher education institutions worldwide to suffice the information needs of academic researchers and that usage of these is influenced by various factors. The factors identified in the reviewed literature as affecting the use of Internet-based information sources among students include: academic discipline affiliation, age, level of study, gender, information and communications technology (ICT) literacy, institutional support, relevance of available information resources, accessibility, marketing and publicity of information sources available, and training. The researcher employed a survey research methodology to achieve the study objectives, through data collection on three fronts. Firstly to investigate the factors hat affect the use of Internet-based information sources from the perspectives of postgraduate students, self-administered questionnaires were distributed to a sample of 200 study participants obtained using quota sampling of the population of students from the three universities. A response rate of 66.5% was achieved. Secondly, data on the organisational factors influencing the use of Internet-based information sources were obtained by conducting semi-structured interviews with selected librarians at the three universities. Lastly, documentary analysis was also used to corroborate data obtained from the survey with postgraduate study participants, as well as from interviews with selected librarians. The findings include that the use of Internet-based information sources is increasingly becoming important for postgraduate students at the selected universities in the Eastern Cape, South Africa. Postgraduate students believe that Internet-based information sources are useful in their academic work. There was moderate use of subscription e-databases and e-journals. Level of study and age were found to affect the use of Internet-based information sources, with older, Masters and PhD students utilising e-databases and e-journals more frequently. Postgraduate students predominantly use search engines to gain access to Internet-based information sources, while Online Public Access Catalogues (OPACs) and library websites were unpopular gateways to Internet-based information sources. Universities in the Eastern Cape were found to be supportive of the use of Internet-based information sources with budgets of libraries and future plans tipped in favour of electronic resource provision. From the findings of the study the key recommendations suggested for improving the use of Internet-based information sources by postgraduate students in the Eastern Cape province of South Africa, include that Information literacy training programmes at the three universities may be tailor-made to cater for the information needs of postgraduate students at varying levels and academic disciplines of study. It was also recommended that the universities incorporate the use of federated searching and searchable journals management software on their library websites, in order to increase the visibility of Internet-based information sources among postgraduate students.
- Full Text:
- Date Issued: 2012
The use of response surface methodology in the evaluation of captopril microparticles manufactured using an oil in oil solvent evaporation technique
- Khamanga, Sandile M, Walker, Roderick B
- Authors: Khamanga, Sandile M , Walker, Roderick B
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184221 , vital:44191 , xlink:href="https://doi.org/10.3109/02652048.2011.629744"
- Description: Captopril (CPT) microparticles were manufactured by solvent evaporation using acetone (dispersion phase) and liquid paraffin (manufacturing phase) with Eudragit® and Methocel® as coat materials. Design of experiments and response surface methodology (RSM) approaches were used to optimize the process. The microparticles were characterized based on the percent of drug released and yield, microcapsule size, entrapment efficiency and Hausner ratio. Differential scanning calorimetry (DSC), Infrared (IR) spectroscopy, scanning electron microscopy (SEM) and in vitro dissolution studies were conducted. The microcapsules were spherical, free-flowing and IR and DSC thermograms revealed that CPT was stable. The percent drug released was investigated with respect to Eudragit® RS and Methocel® K100M, Methocel® K15M concentrations and homogenizing speed. The optimal conditions for microencapsulation were 1.12 g Eudragit® RS, 0.67 g Methocel® K100M and 0.39 g Methocel® K15M at a homogenizing speed of 1643 rpm and 89% CPT was released. The value of RSM-mediated microencapsulation of CPT was elucidated.
- Full Text:
- Date Issued: 2012
- Authors: Khamanga, Sandile M , Walker, Roderick B
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184221 , vital:44191 , xlink:href="https://doi.org/10.3109/02652048.2011.629744"
- Description: Captopril (CPT) microparticles were manufactured by solvent evaporation using acetone (dispersion phase) and liquid paraffin (manufacturing phase) with Eudragit® and Methocel® as coat materials. Design of experiments and response surface methodology (RSM) approaches were used to optimize the process. The microparticles were characterized based on the percent of drug released and yield, microcapsule size, entrapment efficiency and Hausner ratio. Differential scanning calorimetry (DSC), Infrared (IR) spectroscopy, scanning electron microscopy (SEM) and in vitro dissolution studies were conducted. The microcapsules were spherical, free-flowing and IR and DSC thermograms revealed that CPT was stable. The percent drug released was investigated with respect to Eudragit® RS and Methocel® K100M, Methocel® K15M concentrations and homogenizing speed. The optimal conditions for microencapsulation were 1.12 g Eudragit® RS, 0.67 g Methocel® K100M and 0.39 g Methocel® K15M at a homogenizing speed of 1643 rpm and 89% CPT was released. The value of RSM-mediated microencapsulation of CPT was elucidated.
- Full Text:
- Date Issued: 2012
The use of response surface methodology to evaluate the impact of level 2 SUPAC–IR changes on the in vitro release of metronidazole and ranitidine from a fixed-dose combination tablet
- King’ori, Loti D, Walker, Roderick B
- Authors: King’ori, Loti D , Walker, Roderick B
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6391 , http://hdl.handle.net/10962/d1006313
- Description: The purpose of this study was to evaluate the effect of different levels of disintegrant (croscarmellose sodium, CCS), binder (polyvinylprrolidone K30, PVP–K30), and lubricant (magnesium stearate) on the in vitro release of metronidazole (MTZ) and rantidine (RTD) from a solid oral fixed-dose combination tablet. The excipient levels investigated were Level 2 changes in component and composition described in the Scale-Up and Post Approval Changes for Immediate Release (SUPAC–IR) guidance (1). Batches of tablets (1000 units) were manufactured by wet granulation using a Saral high-shear mixer granulator and a Manesty B3B rotary tablet press. Weight uniformity, friability, and disintegration of all tablets were assessed, and all batches complied with compendial specifications. The amount of drug released (Q) at ten minutes was dependent on the levels of CCS in the formulation, and the effect of PVP–K30 and magnesium stearate was dependent on the levels of CCS. Synergistic interactions between independent variables were observed for the Q10 value for RTD, whereas PVP–K30 and magnesium stearate exhibited an antagonistic effect on the Q10 values for MTZ and RTD. The use of response surface methodology facilitated an investigation into the effect of Level 2 component and composition changes, as described in SUPAC–IR, on the in vitro release of MTZ and RTD from a fixed-dose combination (FDC) solid oral dosage form (SODF).
- Full Text:
- Date Issued: 2012
- Authors: King’ori, Loti D , Walker, Roderick B
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6391 , http://hdl.handle.net/10962/d1006313
- Description: The purpose of this study was to evaluate the effect of different levels of disintegrant (croscarmellose sodium, CCS), binder (polyvinylprrolidone K30, PVP–K30), and lubricant (magnesium stearate) on the in vitro release of metronidazole (MTZ) and rantidine (RTD) from a solid oral fixed-dose combination tablet. The excipient levels investigated were Level 2 changes in component and composition described in the Scale-Up and Post Approval Changes for Immediate Release (SUPAC–IR) guidance (1). Batches of tablets (1000 units) were manufactured by wet granulation using a Saral high-shear mixer granulator and a Manesty B3B rotary tablet press. Weight uniformity, friability, and disintegration of all tablets were assessed, and all batches complied with compendial specifications. The amount of drug released (Q) at ten minutes was dependent on the levels of CCS in the formulation, and the effect of PVP–K30 and magnesium stearate was dependent on the levels of CCS. Synergistic interactions between independent variables were observed for the Q10 value for RTD, whereas PVP–K30 and magnesium stearate exhibited an antagonistic effect on the Q10 values for MTZ and RTD. The use of response surface methodology facilitated an investigation into the effect of Level 2 component and composition changes, as described in SUPAC–IR, on the in vitro release of MTZ and RTD from a fixed-dose combination (FDC) solid oral dosage form (SODF).
- Full Text:
- Date Issued: 2012
The use of social media for marketing and communication purpose in institutions of higher learning
- Authors: Mangolothi, Brightness
- Date: 2012
- Subjects: Branding (Marketing) , Social media , Online social networks , Internet marketing , Education, Higher
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8821 , http://hdl.handle.net/10948/d1019698
- Description: Social media have become a widely used tool to communicate with the orgnisations stakeholders. Institutions of higher learning are also venturing into this new way of marketing and communication. This study intended to determine how South African institutions of higher learning are using social media for marketing and communication purposes. Firstly, a literature study was conducted to gain an understanding on how social media are used. Further an empirical study was conducted, which consisted of two phases. The first phase was a case study on NMMU and Stellenbosch University. Structured-interviews, focus groups and observation were used to collect data from the cases. The collected data were then used to construct a questionnaire that was used for a survey. The survey was distributed to all 23 universities, 50 public FET colleges and the 200 private FET college. 92 institutions responded to the survey. The findings prove that there are various opportuntities and challenges in using social media although it should be stressed that the opportunities outweigh the threats. There is no visible difference between colleges social media implementation in relation to institutions of higher learning. Most institutions use more than one social media tool. Facebook is the most widely used social media followed by Twitter, YouTube and LinkedIn. Flickr, MXit, Google+ and Blog are the least used social media. The observations of the NMMU and Stellenbosch University show that these two institutions are striving to engage with their target audiences. Although the institutions are using social media, some of the concerns are that institutions are not measuring their social media use. For those who are measuring, most depend on the free measurement tools which focus only on the quantitative measure. The governance of the social media use is none existent. Most respondents stated that they do not have a policy or guidelines informing social media management. Most of the respondents felt that they want to use more social media tools in future although some of the challenges alluded to were lack of capacity, human resources and budget.
- Full Text:
- Date Issued: 2012
- Authors: Mangolothi, Brightness
- Date: 2012
- Subjects: Branding (Marketing) , Social media , Online social networks , Internet marketing , Education, Higher
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8821 , http://hdl.handle.net/10948/d1019698
- Description: Social media have become a widely used tool to communicate with the orgnisations stakeholders. Institutions of higher learning are also venturing into this new way of marketing and communication. This study intended to determine how South African institutions of higher learning are using social media for marketing and communication purposes. Firstly, a literature study was conducted to gain an understanding on how social media are used. Further an empirical study was conducted, which consisted of two phases. The first phase was a case study on NMMU and Stellenbosch University. Structured-interviews, focus groups and observation were used to collect data from the cases. The collected data were then used to construct a questionnaire that was used for a survey. The survey was distributed to all 23 universities, 50 public FET colleges and the 200 private FET college. 92 institutions responded to the survey. The findings prove that there are various opportuntities and challenges in using social media although it should be stressed that the opportunities outweigh the threats. There is no visible difference between colleges social media implementation in relation to institutions of higher learning. Most institutions use more than one social media tool. Facebook is the most widely used social media followed by Twitter, YouTube and LinkedIn. Flickr, MXit, Google+ and Blog are the least used social media. The observations of the NMMU and Stellenbosch University show that these two institutions are striving to engage with their target audiences. Although the institutions are using social media, some of the concerns are that institutions are not measuring their social media use. For those who are measuring, most depend on the free measurement tools which focus only on the quantitative measure. The governance of the social media use is none existent. Most respondents stated that they do not have a policy or guidelines informing social media management. Most of the respondents felt that they want to use more social media tools in future although some of the challenges alluded to were lack of capacity, human resources and budget.
- Full Text:
- Date Issued: 2012
The valuation of amounts for the purpose of inclusion in gross income
- Authors: Spearman, Tarryn Leigh
- Date: 2012
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:887 , http://hdl.handle.net/10962/d1001641
- Description: The present research investigates the valuation of amounts for the purpose of inclusion in gross income. Because the gross income definition in section 1 of the Income Tax Act includes "amounts in cash or otherwise", valuations are often required in order to establish a value in money terms for amounts received or accrued in a form otherwise than in cash. The basis on which these valuations are made can vary and the courts have frequently been called upon to decide on the correct method of valuation. There has been an ongoing debate in the courts as to whether a strict objective approach or a more flexible subjective approach should be adopted when valuing an amount in a form other than cash, which was finally settled in the decision by the Supreme Court of Appeal in CIR v Brummeria Renaissance (Pty) Ltd, which held that an objective approach must be followed. The present research will demonstrate how the strict rule of interpretation tends to result in purely objective valuations as it requires that the ordinary grammatical meaning of words be applied and does not allow the court to consider the purpose of the legislation or introduce any subjectivity based on the circumstances of each individual taxpayer and the facts of each particular case, which a purposive interpretation approach does. The purposive approach to interpretation is therefore more closely aligned with the subjective approach to valuation. Both the objective and subjective approaches to valuation have advantages and disadvantages, which are addressed in the research. The need for certainty in taxation was articulated as early as 1776 by Adam Smith in his Wealth of Nations. The objective approach appears to create a level of consistency as all income received by a taxpayer is effectively taxed as if received by a third party in an arm’s length transaction. The approach has led to unfair decisions at odds with economic reality and generally accepted accounting principles, which could be challenged on the basis of a lack of equity and fairness as required by the Constitution of the Republic of South Africa. The research demonstrates that an objective method of valuation is neither fully objective nor appropriate in certain circumstances, while a subjective approach may be more appropriate as it ensures that each taxpayer’s individual rights are protected. Although the subjective approach successfully addresses the issue of fairness, it threatens to introduce an unacceptable level of inconsistency and is, in reality, not always administratively feasible. The present research concludes that a trade-off between fairness and consistency is often necessary.
- Full Text:
- Date Issued: 2012
- Authors: Spearman, Tarryn Leigh
- Date: 2012
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:887 , http://hdl.handle.net/10962/d1001641
- Description: The present research investigates the valuation of amounts for the purpose of inclusion in gross income. Because the gross income definition in section 1 of the Income Tax Act includes "amounts in cash or otherwise", valuations are often required in order to establish a value in money terms for amounts received or accrued in a form otherwise than in cash. The basis on which these valuations are made can vary and the courts have frequently been called upon to decide on the correct method of valuation. There has been an ongoing debate in the courts as to whether a strict objective approach or a more flexible subjective approach should be adopted when valuing an amount in a form other than cash, which was finally settled in the decision by the Supreme Court of Appeal in CIR v Brummeria Renaissance (Pty) Ltd, which held that an objective approach must be followed. The present research will demonstrate how the strict rule of interpretation tends to result in purely objective valuations as it requires that the ordinary grammatical meaning of words be applied and does not allow the court to consider the purpose of the legislation or introduce any subjectivity based on the circumstances of each individual taxpayer and the facts of each particular case, which a purposive interpretation approach does. The purposive approach to interpretation is therefore more closely aligned with the subjective approach to valuation. Both the objective and subjective approaches to valuation have advantages and disadvantages, which are addressed in the research. The need for certainty in taxation was articulated as early as 1776 by Adam Smith in his Wealth of Nations. The objective approach appears to create a level of consistency as all income received by a taxpayer is effectively taxed as if received by a third party in an arm’s length transaction. The approach has led to unfair decisions at odds with economic reality and generally accepted accounting principles, which could be challenged on the basis of a lack of equity and fairness as required by the Constitution of the Republic of South Africa. The research demonstrates that an objective method of valuation is neither fully objective nor appropriate in certain circumstances, while a subjective approach may be more appropriate as it ensures that each taxpayer’s individual rights are protected. Although the subjective approach successfully addresses the issue of fairness, it threatens to introduce an unacceptable level of inconsistency and is, in reality, not always administratively feasible. The present research concludes that a trade-off between fairness and consistency is often necessary.
- Full Text:
- Date Issued: 2012
Third crime unlucky
- Authors: Cartwright, Robert Oliver
- Date: 2012
- Subjects: South African fiction (English) -- 21st century , Creative writing (Higher education) , Creative writing -- Fiction
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:5987 , http://hdl.handle.net/10962/d1015729
- Description: This is a contemporary mystery novel set in the Eastern Cape. A town’s airstrip, situated between the golf club and the military base, acts as host to the local flying club and an active skydiving school. An amateur investigator uses unorthodox methods and the help of friends to find the cause of aeroplane fires and sabotage. His investigations lead him via geological research and insurance reports into contact with members of the aviation, property development and military fields.
- Full Text:
- Date Issued: 2012
- Authors: Cartwright, Robert Oliver
- Date: 2012
- Subjects: South African fiction (English) -- 21st century , Creative writing (Higher education) , Creative writing -- Fiction
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:5987 , http://hdl.handle.net/10962/d1015729
- Description: This is a contemporary mystery novel set in the Eastern Cape. A town’s airstrip, situated between the golf club and the military base, acts as host to the local flying club and an active skydiving school. An amateur investigator uses unorthodox methods and the help of friends to find the cause of aeroplane fires and sabotage. His investigations lead him via geological research and insurance reports into contact with members of the aviation, property development and military fields.
- Full Text:
- Date Issued: 2012
Thought amidst waste : conjunctural notes on the Democratic Project in South Africa
- Authors: Pithouse, Richard, 1970-
- Date: 2012
- Language: English
- Type: Conference paper
- Identifier: vital:6195 , http://hdl.handle.net/10962/d1008581
- Description: (from the introduction} In a recent essay Achille Mbembe argues that the rendering of human beings as waste by the interface of racism and capitalism in South Africa means that “for the democratic project to have any future at all, it should necessarily take the form of a conscious attempt to retrieve life and 'the human' from a history of waste”. He adds that “the concepts of 'the human', or of 'humanism', inherited from the West will not suffice. We will have to take seriously the anthropological embeddedness of such terms in long histories of "the human" as waste.”
- Full Text:
- Date Issued: 2012
- Authors: Pithouse, Richard, 1970-
- Date: 2012
- Language: English
- Type: Conference paper
- Identifier: vital:6195 , http://hdl.handle.net/10962/d1008581
- Description: (from the introduction} In a recent essay Achille Mbembe argues that the rendering of human beings as waste by the interface of racism and capitalism in South Africa means that “for the democratic project to have any future at all, it should necessarily take the form of a conscious attempt to retrieve life and 'the human' from a history of waste”. He adds that “the concepts of 'the human', or of 'humanism', inherited from the West will not suffice. We will have to take seriously the anthropological embeddedness of such terms in long histories of "the human" as waste.”
- Full Text:
- Date Issued: 2012
Three tales of Theal: biography, history and ethnography on the Eastern Frontier
- Authors: Naidu, Samantha
- Date: 2012
- Language: English
- Type: Article , text
- Identifier: vital:24529 , http://hdl.handle.net/10962/36216 , https://www.jstor.org/stable/23267873?seq=1#page_scan_tab_contents , https://orcid.org/0000-0001-9456-8657
- Full Text:
- Date Issued: 2012
- Authors: Naidu, Samantha
- Date: 2012
- Language: English
- Type: Article , text
- Identifier: vital:24529 , http://hdl.handle.net/10962/36216 , https://www.jstor.org/stable/23267873?seq=1#page_scan_tab_contents , https://orcid.org/0000-0001-9456-8657
- Full Text:
- Date Issued: 2012
Ties that bind
- Authors: Tshisela, Namhla
- Date: 2012
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:20988 , http://hdl.handle.net/10962/5913
- Description: This collection of short stories about contemporary black South African women reveals their hopes and anxieties, and explores their relationships with themselves, their families, and the people around them. It sets out to challenge stereotypes about black women being browbeaten in a country riddled by poverty and disease by portraying women successfully forging their identities in society.
- Full Text:
- Date Issued: 2012
- Authors: Tshisela, Namhla
- Date: 2012
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:20988 , http://hdl.handle.net/10962/5913
- Description: This collection of short stories about contemporary black South African women reveals their hopes and anxieties, and explores their relationships with themselves, their families, and the people around them. It sets out to challenge stereotypes about black women being browbeaten in a country riddled by poverty and disease by portraying women successfully forging their identities in society.
- Full Text:
- Date Issued: 2012
To evaluate the roles and functioning of community health committees within the Nelson Mandela Bay Municipality
- Authors: Gumbi, Nkhosivile M
- Date: 2012
- Subjects: Public health -- South Africa -- Nelson Mandela Bay Municipality -- Citizen participation , Political participation -- South Africa -- Nelson Mandela Bay Municipality -- Evaluation
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9196 , http://hdl.handle.net/10948/d1020389
- Description: Community participation is a concept that has been advocated for by bodies such as the World Health Organization (WHO) for over two decades. In South Africa, community participation was included in the National Health Act (61 of 2003). Clinic and Community health facility committees were legislated as a method of involving communities in promoting health and improving health outcomes. During the year 2010, a process was initiated by the Nelson Mandela Bay Municipality (NMBM) to establish and train health committees at all health facilities. The purpose of this research report was to evaluate the effectiveness of community health committees within the Nelson Mandela Bay Municipality, since 2010. Guidelines given in the Policy on the Establishment and Functioning of Clinic and Community Health Centre Committee (2009) were utilized as a point of reference for this study. The results showed that the community health committees trained in 2010 were functioning effectively as a result of the policy guidelines given. There still needs to be an improvement in the involvement of ward councilors, as stipulated in the National Health Act (61 of 2003), as well as in the implementation of the fundraising role, as set out in the Health Departments policy guidelines for health committees to implement.
- Full Text:
- Date Issued: 2012
- Authors: Gumbi, Nkhosivile M
- Date: 2012
- Subjects: Public health -- South Africa -- Nelson Mandela Bay Municipality -- Citizen participation , Political participation -- South Africa -- Nelson Mandela Bay Municipality -- Evaluation
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9196 , http://hdl.handle.net/10948/d1020389
- Description: Community participation is a concept that has been advocated for by bodies such as the World Health Organization (WHO) for over two decades. In South Africa, community participation was included in the National Health Act (61 of 2003). Clinic and Community health facility committees were legislated as a method of involving communities in promoting health and improving health outcomes. During the year 2010, a process was initiated by the Nelson Mandela Bay Municipality (NMBM) to establish and train health committees at all health facilities. The purpose of this research report was to evaluate the effectiveness of community health committees within the Nelson Mandela Bay Municipality, since 2010. Guidelines given in the Policy on the Establishment and Functioning of Clinic and Community Health Centre Committee (2009) were utilized as a point of reference for this study. The results showed that the community health committees trained in 2010 were functioning effectively as a result of the policy guidelines given. There still needs to be an improvement in the involvement of ward councilors, as stipulated in the National Health Act (61 of 2003), as well as in the implementation of the fundraising role, as set out in the Health Departments policy guidelines for health committees to implement.
- Full Text:
- Date Issued: 2012
To investigate and evaluate the implementation of the supply chain management in service delivery with specific focus on procurement processes of goods and services in the head office of the Eastern Cape department of health
- Authors: Mnguni, Nombuyiselo
- Date: 2012
- Subjects: Business logistics -- South Africa -- Eastern Cape -- Management , Business logistics -- South Africa -- Eastern Cape , Management -- Procurement , Supply and demand
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8572 , http://hdl.handle.net/10948/1599 , Business logistics -- South Africa -- Eastern Cape -- Management , Business logistics -- South Africa -- Eastern Cape , Management -- Procurement , Supply and demand
- Description: Supply Chain Management is a well recognized managerial tool and government initiative, primarily aimed at improving all the aspects of the procurement activities in government organizations or any type of the sector. It focuses on meeting the needs of the service providers as well as of the customers. In 1994, South African Government came up with new initiatives to manage its budget and finance resources to meet the needs of the people. One of the new initiatives that the new Government introduced was the Supply Chain Management (SCM). The Constitution of the Republic of South Africa, Act No.108 of 1996, as amended regulates procurement through Section 217. The statutes states that “217(1) when an Organ of State in the national, provincial or local sphere of government, or any institution identified in national legislation, contracts for goods or services, it must do so in accordance with a system which is fair, equitable, transparent, competitive and cost-effective The procurement reform processes were supported by the introduction of a number of legislative measures, including the adoption of the Public Financial Management Act (PFMA) and the Preferential Procurement Policy Framework Act (PPPFA). Public Finance Management Act (PFMA) is a financial act that was developed in 1999 to reform the public financial management of South Africa. The Act promotes the objective of good financial management in order to maximise delivery through the efficient and effective use of limited resources. Public Financial Management Act (PFMA) emphasizes on efficiency, transparency and economic utilization of public funds. The Treasury Regulations 16.5.3 states that, ‘when procuring goods and services, the procurement procedures must be in accordance with a system that is fair, equitable, transparent, competitive and cost-effective. Even though government departments have started implementing the Supply Chain Management strategies, there are still some challenges and deficiencies that hinder appropriate implementation. There are some deficiencies in tender award systems, ineffectiveness of SCM training materials, lack of communication between management and SCM or implementing staff as a result the implementing staff is not aware of the organization’s goals regarding supply chain management activities. Lack of monitoring, evaluation and reporting is also another challenge. Due to these challenges, the Head Office of the Eastern Cape Department of Health had incurred some expenses in trying to address these yet the Supply Chain Management has little impact in improving the service delivery. The key research objective of this study is to investigate and evaluate the implementation of Supply Chain Management in service delivery with specific focus in procurement processes of goods and services in Head Office of Eastern Cape Department of Health. The study intends to establish and highlight the challenges that the Head Office of the Eastern Cape Department of Health is presently faced with in regard to implementation of the Supply Chain Management and the impact it has in service delivery. Data gathering techniques which include interviews and questionnaires had been used. The objectives, methodology and results of the study are presented. The conclusions and recommendations had been made with the basis that they will assist the department in improving the implementation of the Supply Chain Management which will have a positive impact in the service delivery. Further steps needs to be taken by the Provincial Treasuries in assisting department to improve in the implementation of the Supply Chain Management. Further research conduct is recommended for all the institutions of the department of Health as this study was focusing on Head Office only.
- Full Text:
- Date Issued: 2012
- Authors: Mnguni, Nombuyiselo
- Date: 2012
- Subjects: Business logistics -- South Africa -- Eastern Cape -- Management , Business logistics -- South Africa -- Eastern Cape , Management -- Procurement , Supply and demand
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8572 , http://hdl.handle.net/10948/1599 , Business logistics -- South Africa -- Eastern Cape -- Management , Business logistics -- South Africa -- Eastern Cape , Management -- Procurement , Supply and demand
- Description: Supply Chain Management is a well recognized managerial tool and government initiative, primarily aimed at improving all the aspects of the procurement activities in government organizations or any type of the sector. It focuses on meeting the needs of the service providers as well as of the customers. In 1994, South African Government came up with new initiatives to manage its budget and finance resources to meet the needs of the people. One of the new initiatives that the new Government introduced was the Supply Chain Management (SCM). The Constitution of the Republic of South Africa, Act No.108 of 1996, as amended regulates procurement through Section 217. The statutes states that “217(1) when an Organ of State in the national, provincial or local sphere of government, or any institution identified in national legislation, contracts for goods or services, it must do so in accordance with a system which is fair, equitable, transparent, competitive and cost-effective The procurement reform processes were supported by the introduction of a number of legislative measures, including the adoption of the Public Financial Management Act (PFMA) and the Preferential Procurement Policy Framework Act (PPPFA). Public Finance Management Act (PFMA) is a financial act that was developed in 1999 to reform the public financial management of South Africa. The Act promotes the objective of good financial management in order to maximise delivery through the efficient and effective use of limited resources. Public Financial Management Act (PFMA) emphasizes on efficiency, transparency and economic utilization of public funds. The Treasury Regulations 16.5.3 states that, ‘when procuring goods and services, the procurement procedures must be in accordance with a system that is fair, equitable, transparent, competitive and cost-effective. Even though government departments have started implementing the Supply Chain Management strategies, there are still some challenges and deficiencies that hinder appropriate implementation. There are some deficiencies in tender award systems, ineffectiveness of SCM training materials, lack of communication between management and SCM or implementing staff as a result the implementing staff is not aware of the organization’s goals regarding supply chain management activities. Lack of monitoring, evaluation and reporting is also another challenge. Due to these challenges, the Head Office of the Eastern Cape Department of Health had incurred some expenses in trying to address these yet the Supply Chain Management has little impact in improving the service delivery. The key research objective of this study is to investigate and evaluate the implementation of Supply Chain Management in service delivery with specific focus in procurement processes of goods and services in Head Office of Eastern Cape Department of Health. The study intends to establish and highlight the challenges that the Head Office of the Eastern Cape Department of Health is presently faced with in regard to implementation of the Supply Chain Management and the impact it has in service delivery. Data gathering techniques which include interviews and questionnaires had been used. The objectives, methodology and results of the study are presented. The conclusions and recommendations had been made with the basis that they will assist the department in improving the implementation of the Supply Chain Management which will have a positive impact in the service delivery. Further steps needs to be taken by the Provincial Treasuries in assisting department to improve in the implementation of the Supply Chain Management. Further research conduct is recommended for all the institutions of the department of Health as this study was focusing on Head Office only.
- Full Text:
- Date Issued: 2012
To investigate the lack of sustainability of emerging contractors at Nxuba and Nkonkobe Local Municipalities
- Authors: Mnqokoyi, Unathi
- Date: 2012
- Subjects: Construction industry -- South Africa -- Eastern Cape , Contractors -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8788 , http://hdl.handle.net/10948/d1014547
- Description: The research thesis examines the lack of sustainability of emerging contractors at Nxuba and Nkonkobe local municipalities in the Eastern Cape. SMMEs and emerging contractors are viewed as necessary to improve economic, social and environmental development. For the developmental vision to be achieved, the emerging contractors have to be sustainable businesses. The delivery of sustainable services requires the presence and utilisation of sustainable emerging contractors. The purpose of the study is to conduct an in-depth investigation on the lack of sustainability of emerging contractors at the local municipal level. The study will further establish whether there is a link between lack of efficiency and effectiveness and then provide possible recommendations to the problem. The survey was conducted among emerging contractors to determine from them what their experiences were with sustainability issues including the emerging contractor development programs. The survey also focused on the amount of opportunities given to them by the local government sphere and the effect of their lack of access to finance. It is envisaged that the study will assist emerging contractors to address sustainability of their businesses. Both government and private sector clients are set to benefit from an improved set of emerging contractors. Improvements are expected in the social, economic and environmental spheres. The majority of emerging contractors appear to have failed to secure sustainable work and as such have not achieved business growth in the past 3 years. The study reveals that local government clients have contributed with late payments to the poor rating of the emerging contractors on creditability with clients, suppliers and financiers.
- Full Text:
- Date Issued: 2012
- Authors: Mnqokoyi, Unathi
- Date: 2012
- Subjects: Construction industry -- South Africa -- Eastern Cape , Contractors -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8788 , http://hdl.handle.net/10948/d1014547
- Description: The research thesis examines the lack of sustainability of emerging contractors at Nxuba and Nkonkobe local municipalities in the Eastern Cape. SMMEs and emerging contractors are viewed as necessary to improve economic, social and environmental development. For the developmental vision to be achieved, the emerging contractors have to be sustainable businesses. The delivery of sustainable services requires the presence and utilisation of sustainable emerging contractors. The purpose of the study is to conduct an in-depth investigation on the lack of sustainability of emerging contractors at the local municipal level. The study will further establish whether there is a link between lack of efficiency and effectiveness and then provide possible recommendations to the problem. The survey was conducted among emerging contractors to determine from them what their experiences were with sustainability issues including the emerging contractor development programs. The survey also focused on the amount of opportunities given to them by the local government sphere and the effect of their lack of access to finance. It is envisaged that the study will assist emerging contractors to address sustainability of their businesses. Both government and private sector clients are set to benefit from an improved set of emerging contractors. Improvements are expected in the social, economic and environmental spheres. The majority of emerging contractors appear to have failed to secure sustainable work and as such have not achieved business growth in the past 3 years. The study reveals that local government clients have contributed with late payments to the poor rating of the emerging contractors on creditability with clients, suppliers and financiers.
- Full Text:
- Date Issued: 2012
To what extent can microfinance sustain the livelihoods of the women of Mdantsane (Ward N.U. 9)
- Authors: Cuntu, Somila
- Date: 2012
- Subjects: Microfinance -- South Africa -- Eastern Cape , Women in economic development --South Africa -- Eastern Cape , Women -- South Africa -- Eastern Cape -- Social conditions
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9110 , http://hdl.handle.net/10948/d1014636
- Description: I have observed that in Mdantsane there is a clear gap between men and women, as people are tradition-bound, and men are often the breadwinners in their households, which leave some women sidelined and only left with household chores. Therefore this research aims to investigate these inequalities, and if microfinance can contribute positively towards the development of these women, so that they can develop and sustain their lifestyles. Chapter two of this research, containing available literature on this particular study which is sustainable livelihoods and microfinance for poor women, and covers both local as well as international studies. Here microfinance and sustainable livelihoods will be conceptualised accordingly so as to shed light on the subject. The third chapter covers the methodology used in the current study which clearly outlines the methodological framework, the research instruments, participants as well as the research design and procedure. The fourth chapter provides the findings and of the the current study, this will outline the main themes that surface and are prevalent among the participants. Chapter five will consist of the discussion of the results. Lastly chapter six will provide the conclusion as well as well as recommendations relevant to the results of this study.
- Full Text:
- Date Issued: 2012
- Authors: Cuntu, Somila
- Date: 2012
- Subjects: Microfinance -- South Africa -- Eastern Cape , Women in economic development --South Africa -- Eastern Cape , Women -- South Africa -- Eastern Cape -- Social conditions
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9110 , http://hdl.handle.net/10948/d1014636
- Description: I have observed that in Mdantsane there is a clear gap between men and women, as people are tradition-bound, and men are often the breadwinners in their households, which leave some women sidelined and only left with household chores. Therefore this research aims to investigate these inequalities, and if microfinance can contribute positively towards the development of these women, so that they can develop and sustain their lifestyles. Chapter two of this research, containing available literature on this particular study which is sustainable livelihoods and microfinance for poor women, and covers both local as well as international studies. Here microfinance and sustainable livelihoods will be conceptualised accordingly so as to shed light on the subject. The third chapter covers the methodology used in the current study which clearly outlines the methodological framework, the research instruments, participants as well as the research design and procedure. The fourth chapter provides the findings and of the the current study, this will outline the main themes that surface and are prevalent among the participants. Chapter five will consist of the discussion of the results. Lastly chapter six will provide the conclusion as well as well as recommendations relevant to the results of this study.
- Full Text:
- Date Issued: 2012