An analysis of how Zimbabwean women negotiate the meaning of HIV/AIDS prevention television advertisements
- Authors: Hungwe, Caroline
- Date: 2006
- Subjects: Mass media and women -- Zimbabwe AIDS (Disease) in mass media -- Zimbabwe Mass media -- Audiences Women -- Zimbabwe -- Social conditions
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3435 , http://hdl.handle.net/10962/d1002889
- Description: Within the context of debates concerning the impact of media on audiences, this study takes the form of a qualitative audience reception analysis; to investigate how a particular group of female audiences situated in Zimbabwe interprets televised HIV/AIDS prevention advertisements. It examines the extent to which the social context influences the audiences’ acceptance or rejection of preferred readings encoded in the texts. The study is situated within the broad theoretical and methodological framework of both the communication for development and the cultural studies approaches to the study of the media. Data for the investigation was collected through the focus group and in-depth interview methods as well as through the websites and organisational documents produced by the encoders of the advertisements. The findings indicate that the female audiences’ interpretative strategies were informed by their lived experience as well as pre-existing knowledge. Based on the findings it can be deduced that, contrary to earlier beliefs and media theories such as that of the “hypodermic needle” theory the audience of public communication is not a passive homogenous mass that easily succumbs to media influences, rather the audience is active in the production of meaning, but under determinate conditions in particular contexts. The texts, the producing institutions and the social history of the audiences supply these conditions.
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An appraisal of the impact of the Fast Track Land Reform Programme on land use practices, livelihoods and the natural environment at three study areas in Kadoma District, Zimbabwe
- Authors: Chigumira, Easther C
- Date: 2006
- Subjects: Land reform -- Zimbabwe , Land tenure -- Zimbabwe , Land settlement -- Government policy -- Zimbabwe , Land use -- Government policy -- Zimbabwe , Agriculture -- Zimbabwe , Sustainable development -- Zimbabwe , Rural development -- Zimbabwe , Zimbabwe -- Economic conditions , Natural resources -- Zimbabwe , Environmental policy -- Zimbabwe , Farms, Large -- Zimbabwe , Farms, Small -- Zimbabwe
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4815 , http://hdl.handle.net/10962/d1005489 , Land reform -- Zimbabwe , Land tenure -- Zimbabwe , Land settlement -- Government policy -- Zimbabwe , Land use -- Government policy -- Zimbabwe , Agriculture -- Zimbabwe , Sustainable development -- Zimbabwe , Rural development -- Zimbabwe , Zimbabwe -- Economic conditions , Natural resources -- Zimbabwe , Environmental policy -- Zimbabwe , Farms, Large -- Zimbabwe , Farms, Small -- Zimbabwe
- Description: This research appraises the impact of the Fast Track Land Reform Programme at three resettled communities in Kadoma District, Zimbabwe. In particular it assesses the livelihood practices of land recipients and their effects on the natural environment. Two of the communities, Lanteglos and CC Molina were resettled under the A1 villagised and self-contained settlement scheme and are found in the Natural Farming Region III. Pamene, the third community, was resettled under the A2 small-scale commercial settlement scheme and is found in the Natural Farming Region IIb. Multiple research methods including household surveys, interviews, observations, reviews of literature and map construction through the use of Geographic Information Systems, allowed for the collection of empirical, descriptive, and spatial data to provide for the appraisal. The land use practices included dry land crop production, livestock rearing, vegetable gardening and exploitation of the natural environment for a variety of purposes. Farming was mostly subsistence with the use of traditional equipment by all three communities. Tenure was perceived to be insecure by beneficiaries and although a variety of papers to show ownership were held, none provided for leasing or freehold tenure. Despite acquiring natural capital from the resettlement process, the findings of this research show low levels of financial, physical and social capital amongst beneficiaries. Moreover climatic variability, the declining macro-economic and unstable political environment and little support from government have adversely affected the livelihoods of beneficiaries. The implication of all this has been a reduction in livelihoods that are based solely on agricultural production, leading to off-farm practices primarily exploiting the natural environment. The long term effect would be increased degradation of the environment, leading to reduced arable and grazing land, and thereby hindering sustainable livelihoods from farming. Recommendations are proposed based on this research’s findings being typical in Zimbabwe. Central to this is the need for government to revise its present land policy and, provide for a comprehensive and holistic land policy that should be based on the vision of how agriculture should evolve in Zimbabwe
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An edition of a selection of poems by John Randal Bradburne
- Authors: Hacksley, Helen Elizabeth
- Date: 2006
- Subjects: Bradburne, John, -1979 Bradburne, John, -1979 -- Criticism and interpretation Poets, South African -- 20th century -- Biography
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2288 , http://hdl.handle.net/10962/d1008069
- Description: This thesis examines the life and work of John Randal Bradburne (1921-1979), poet, mystic, musician, cenobite, sometime soldier, pilgrim and wanderer. His religious experiences, particularly, gave rise to a vast corpus of verse, virtually all of it as yet unpublished. This study provides a brief overview of his life, and a critical and textual introduction to a sample selection of poems entitled Bradburne 's Assays. The biography has been compiled from published and unpublished sources, as well as from personal interviews and correspondence with Bradburne's friends, relatives and associates in South Africa, Zimbabwe and the United Kingdom. Chief among these are two unpublished biographies by Judith, Countess of List owe I. Bradburne's extant corpus consists of over five thousand titled pieces of verse, ranging from brieflyrics to verses hundreds of pages long. The forty-seven poems comprising Bradburne 's Assays, published here for the first time, were selected and arranged by Bradburne himself in a single sequence. A unique collection in his corpus, they are unified by their common sonnet form and their contemplative approach to secular and religious experiences. An accurate reading text of this set of poems, transcribed from Bradburne's typescripts, currently held at Holyhead in Wales, is provided. These typescripts have been electronically scanned and are presented in the Appendix. Editorial intrusion, which has been kept to a minimum, is recorded in the critical apparatus beneath the text of the poems. Since all the poems in this ed ition are presented here for the first time, each is accompanied by detailed commentary on their form and content. Where necessary, interpretations of obscure passages have been suggested. A general index to the Introduction and Commentary is supplied, along with indexes of first lines and titles of the poems. It is hoped that this thesis will stimulate further study of the life and work of a unique and intriguing figure.
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An evaluation of formal mentoring programmes within two South African organisations
- Authors: Shelton, Delyse Elizabeth
- Date: 2006
- Subjects: Mentoring -- South Africa , Organizational effectiveness -- Evaluation , Organizational effectiveness -- South Africa , Corporate culture -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:1186 , http://hdl.handle.net/10962/d1002803 , Mentoring -- South Africa , Organizational effectiveness -- Evaluation , Organizational effectiveness -- South Africa , Corporate culture -- South Africa
- Description: The benefits of informal mentoring are numerous and organisations have recognised these benefits in terms of organisational development. There has been an attempt to harvest these benefits through the introduction of formal mentoring programmes as a tool to fast track and then ultimately retain internal capability. This research on formal mentoring programmes occurred within a qualitative paradigm and data was obtained through document analysis and interviews from five mentoring pairs in one organisation and four mentoring pairs in another. The data was then presented and analysed in terms of the models proposed in the literature. The aim of this research was to evaluate formal mentoring programmes within South African organisations based on a framework provided by the literature. It was found that the literature proposed no formal evaluation model and thus, one was developed based on models of programme evaluation and formal mentoring implementation models. On the evaluation of the two formal mentoring programmes, it was found that there are some issues raised in the literature that are pertinent to both organisations but that there were also issues that were only relevant to one of the programmes. According to the research the differences in perceived success of the mentoring programme lay in the goals of the programme relating to the broader goals and culture of the organisation. It is recommended that future research investigate the impact of organisational culture on the effectiveness of formal mentoring programmes. The research also identified a need for supportive resources although this study did not assess the appropriateness and sufficiency of the resources. Organisations also need to implement effective evaluative practices in order to implement effective changes to the programme.
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An evaluation of the Nelson Mandela Metropole as a location to attract investment
- Authors: Nonxuba, Philile Zipho
- Date: 2006
- Subjects: Nelson Mandela Metropolitan Municipality (Eastern Cape, South Africa) , Nelson Mandela Metropolitan Municipality (Eastern Cape, South Africa) -- Economic conditions , Economic development -- South Africa -- Eastern Cape , Manufacturing industries -- South Africa -- Eastern Cape , Business enterprises -- South Africa -- Eastern Cape , Investments -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:973 , http://hdl.handle.net/10962/d1002707 , Nelson Mandela Metropolitan Municipality (Eastern Cape, South Africa) , Nelson Mandela Metropolitan Municipality (Eastern Cape, South Africa) -- Economic conditions , Economic development -- South Africa -- Eastern Cape , Manufacturing industries -- South Africa -- Eastern Cape , Business enterprises -- South Africa -- Eastern Cape , Investments -- South Africa -- Eastern Cape
- Description: The Nelson Mandela Metropole is the largest contributor to the Eastern Cape Province’s economy and its share of the production of the Eastern Cape is about 41, 3 % per annum. This requires that the competitiveness of the Metropole be improved in order to enable it to meet the challenges of the Province. The objective of the GEAR policy strategy places a focus on the leading coastal industrial locations of South Africa. Furthermore, the national government has shifted the responsibility of service delivery to local governments in an effort to reinforce the integrated development planning process in municipalities. To meet those challenges, the Metropole has focused its attention on improving local resources. To enhance the performance of the manufacturing industry of the Metropole, it is necessary to ensure that the Metropole has locational attributes to attract new investment. Such attributes include creation of closely located industries. This will help the firms to engage in competition as well as engage in co-operative activities among themselves. The study employs a variety of theories to highlight the need to enhance productivity of industries in order to attract new investment. These theories include the new (endogenous) growth theory that argues that productivity growth is determined by introduction of new technologies. Such technologies accrue because ideas that contribute to their development are nonrival, and thus their creation has a fixed cost and zero marginal cost. The property of fixed cost in the creation of ideas results in the emergence of increasing returns to scale. The Porter’s Diamond framework is used in the study to take the issue of productivity growth further. Its thrust is that in particular nations some industries experience high productivity growth rates. It further argues that the locational attributes are responsible for these industries in registering high productivity growth levels. These attributes include the creation of advanced resources such as a skilled labour force. The data obtained from the survey of the research on the manufacturing industries forms part of this study. The findings of the survey reveal that although the manufacturing sector of the South African region has registered some significant success, there is still some room for improving its competitiveness. It revealed that development of the local markets through competition and cooperation among the industries would help to render these industries internationally competitive. This study concludes with some recommendations. These recommendations place emphasis on improvement of infrastructure, quality of labour force, and development of the region’s market. In order to carry out the recommendations effectively, government policy has to be repositioned so as to enhance its visibility among the stakeholders in the economy. Of importance is to ensure the promotion of policy that supports geographically concentrated businesses.
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An exploration of the availability, development and use of learning support materials on waste management in Kwazulu-Natal : a case study
- Authors: Manqele, Mbaweni Beauty
- Date: 2006
- Subjects: Waste disposal in the ground -- South Africa -- KwaZulu-Natal Waste products -- Government policy -- South Africa Refuse and refuse disposal -- Government policy -- South Africa Refuse and refuse disposal -- Environmental aspects -- South Africa -- KwaZulu-Natal Refuse and refuse disposal -- South Africa -- KwaZulu-Natal Hazardous wastes -- Management -- South Africa -- KwaZulu-Natal Hazardous waste sites -- Government policy -- South Africa Environmental education -- South Africa -- KwaZulu-Natal Teaching -- Aids and devices -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1496 , http://hdl.handle.net/10962/d1003377
- Description: This case study was done in KwaZulu–Natal province in South Africa within two municipalities Ethekwini and Umsunduzi Municipality. Three communities participated in this study. The research is motivated by the lack of cooperation between some municipalities and Community Based Organisations (CBOs) in implementing the National Waste Management Strategy (NWMS) at a local level. The primary goal is to explore the availability and development of learning support materials (LSMs) that relates to waste management in collaboration with CBOs and local councillors. The secondary goal is to explore the use of learning support material to promote participation in the implementation of the NWMS. Coresearchers were from the Community Based Organisations as well as local councillors who are located within the communities of these CBOs. Pseudonyms for co-researchers from CBOs and Councillors and the name of their townships have been used to protect co-researchers. A literature review has been conducted to explore research that has been done on the development, usage, accessibility and distribution of the LSMs. Data collection methods included semi-structured interviews; field visits to communities, tape recording of discussions and the keeping of a field journal. Some of the key findings included that LSMs is used by both CBOs and Councillors to try to reduce local environmental problems. It also identified that there are no formal mechanisms between CBOs and Municipalities in dealing with waste management programmes within the identified communities. The other important finding was that the participation of CBOs in the development of LSMs normally excludes the user groups as a result language used is not always understood. Illustrations used in some cases may be misinterpreted if the reader is not English literate as most of material in circulation is written in English. Some recommendations for further research have been made in relation to the findings made in the study. These included recommendations on the development, usage of LSMs, participation of stakeholders in resource development within the context of CBOs and local municipalities.
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An exploratory study into various stakeholders' perceptions and experiences of participative management in a high school in the Cala district, Eastern Cape
- Authors: Stofile, Attwell Mzamane
- Date: 2006
- Subjects: School management and organization -- South Africa -- Eastern Cape Educational leadership -- South Africa -- Eastern Cape Educational change -- South Africa -- Eastern Cape Management -- Employee participation -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1538 , http://hdl.handle.net/10962/d1003420
- Description: Although the word “participation” has been with mankind for a long time and is widely used by writers on management areas, it still remains difficult to define precisely what it means. As a result, “participation” is one of the most misunderstood and confusing ideas that have emerged from the field of human relations. This study seeks to explore the perceptions and understanding that the various stakeholders have about participative management. The purpose is to find out the meaning and interpretations the stakeholders attach to the idea of participation. This study is an interpretive case study of a Senior Secondary School in the Cala District of the Eastern Cape. A phenomenological approach was employed in data gathering using two data collection tools namely questionnaires and interviews. The collected data provided insight into stakeholders’ views on participative management, highlighted challenges around the implementation of participative management, and revealed strategies to be utilized in promoting participation. The findings reveal that participation is a controversial idea that is easier said than done. There is no recipe for the implementation of a participative approach; it depends on the situation and nature of the subordinates. Furthermore, organization members need to adopt new thinking patterns in order to be responsive to change. Open communication emerges as the key to having genuine participation. However, participation still brings anxiety and fear of losing power to those managers who do not take kindly to it. It is recommended that good interpersonal relations should be maintained at all times to promote participation and that for schools to be effective, partnership with parents and stakeholders is essential.
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An insight into magma supply to the Karoo Igneous Province a geochemical investigation of Karoo dykes adjacent to the Northwestern sector of the Lesotho volcanic remnant
- Authors: Mitha, Vindina Ramesh
- Date: 2006
- Subjects: Flood basalts -- Lesotho , Volcanism -- Lesotho , Magmatism -- Lesotho , Dikes (Geology) -- Lesotho , Geochemistry -- Lesotho , Lava -- Lesotho
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4973 , http://hdl.handle.net/10962/d1005585 , Flood basalts -- Lesotho , Volcanism -- Lesotho , Magmatism -- Lesotho , Dikes (Geology) -- Lesotho , Geochemistry -- Lesotho , Lava -- Lesotho
- Description: The emplacement of continental flood basalt provinces is often ascribed to fissure eruption. However, in many provinces the locations of actual vent complexes remains illusive. In southern Africa, the Karoo continental flood basalt province was erupted during the Jurassic between 183 and 179 Ma. The southernmost outcrop of the Karoo continental flood basalt lavas is the Lesotho remnant; and is comprised of the Drakensberg Group which forms the uppermost portion of the Karoo Supergroup. The geochemical stratigraphy for the Drakensberg Group is well established. At the base, there are a number of small volume compositionally diverse units, which form the Barkly East Formation, overlying which, there are larger volume, compositionally less variable units of the Lesotho Formation, which form the bulk of the volcanic sequence. The Lesotho remnant is associated with an abundance of dykes in the adjacent vicinity. This suggests that the lavas were fed from local rather than distal eruption sites. This study presents whole rock major and trace element data for 94 dykes and three sills from the northern Lesotho - northeastern Free State region and demonstrates that on the basis of geochemistry, all 97 intrusions can be correlated with various units of the northern Barkly East and Lesotho Formations. In addition, the petrographical; characteristics, orientation and distribution of the dykes do not correlate with geochemistry. Geochemical discrimination diagrams have been used to identify five compositionally diverse dykes, which are similar to the northern Barkly East Formation units. Three dykes are characteristic of the Letele unit and two are compositionally similar to the Wonderkop unit. Although the geochemical characteristics of the Lesotho Formation units are rather well constrained, the composition of these units is typified by considerable overlap in composition. Therefore, since unambiguous classification of dykes with geochemical similarities to the various units of the Lesotho Formation is unachievable using an empirical approach, the multivariate forward-stepwise discriminant function analysis (DFA) technique was used to facilitate the classification of the remaining 89 dykes and three sills. Forward-stepwise DFA classified 23 dykes as having compositional similarities to the Mafika Lisiu unit, 29 as having compositions of the Maloti or Senqu types; and 32 as having the composition of the Mothae type. In addition, eight dykes are compositionally similar to the Oxbow dykes, which intrude the Senqu unit in northern Lesotho. These results suggest that that the Lesotho remnant was fed from local eruption sites and that long distance magma transport for the bulk of the Lesotho remnant basalt lavas is unlikely.
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An investigation into fan identity among supporters of the English soccer premier league in Lusaka, Zambia
- Authors: Komakoma, Leah
- Date: 2006
- Subjects: Soccer -- Zambia -- Lusaka Soccer fans -- Zambia -- Lusaka Soccer -- Social aspects -- Zambia -- Lusaka Mass media and sports -- Zambia -- Lusaka , Sports journalism -- Zambia -- Lusaka , Sports -- Sociological aspects -- Zambia -- Lusaka
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3448 , http://hdl.handle.net/10962/d1002902
- Description: This study investigates Zambians’ construction of identities based on their following of the English soccer premier league. The study seeks to understand how Zambian supporters of this league construct their identities based on their encounter with foreign teams/players and how they appropriate the meanings obtained through such viewing in their daily lives. The study is informed by the theories of fandom. Using an ethnographic critique of the media imperialism thesis, the study attempts to explore the meanings that the fans of the English soccer league in urban Lusaka make of the mediated soccer games, while in and outside the viewing spaces – the bars – where the games are ritually watched in groups. Based on the qualitative methods of focus group discussions, individual in-depth interviews and observations, the study probes the phenomenon of the consumption of English premier league football in countries abroad, focusing specifically on the experiences of fans in Lusaka, Zambia. Observation of this phenomenon in Lusaka reveals that fans find pleasure in the tactics that the teams in the league display, the professionalism of the players, goal scoring and self-empowerment for the few women supporters. This study probes these issues in greater depth. The foremost conclusion of the research is that it neither completely rejects nor accepts the media imperialism thesis. Instead, meanings should be understood within the context of the lived experience and reality of the fans.
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An investigation into problems facing small-to-medium sized enterprises in achieving growth in the Eastern Cape : enhancing the strategy for developing small 'growth potential' firms in the Eastern Cape
- Authors: Sha, Shafeek
- Date: 2006
- Subjects: Small business -- Management , Small business -- South Africa -- Eastern Cape , Small business -- South Africa -- Eastern Cape -- Growth , Business enterprises -- Economic aspects -- South Africa -- Eastern Cape , Economic development -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:1173 , http://hdl.handle.net/10962/d1002789 , Small business -- Management , Small business -- South Africa -- Eastern Cape , Small business -- South Africa -- Eastern Cape -- Growth , Business enterprises -- Economic aspects -- South Africa -- Eastern Cape , Economic development -- South Africa -- Eastern Cape
- Description: As the world economy continues to move towards increased integration, some of the greatest opportunities for Small-to-Medium Sized Enterprises (SMEs) will derive from their ability to participate in the global marketplace. It is generally accepted that SMEs are becoming increasingly important in terms of employment, wealth creation, and the development of innovation. However, there are considerable doubts about the quality of management in this sector with policy-makers suggesting that there are particular weaknesses in innovation, a lack of financial acumen, marketing, entrepreneurial flair, practical knowledge, and human resource management. As a result, many firms do not reach their full potential and fail to grow. According to organisational life cycle models, the introductory phase is particularly important since it is generally known and accepted that there is a high mortality rate of SMEs within the first two years. Given this high failure rate, it becomes vital to research the factors/characteristics/management abilities that are required to enable the SME to survive and indeed progress to the growth phase of the organizational life cycle. This research seeks to investigate the internal and external factors that are consistent in the success of SMEs who have reached the growth phase. A significant contribution to the enhancement of the growth potential of a firm will be made through the understanding of these factors.
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An investigation into the implementation of participative management in a rural school in the Pietermaritzburg district
- Authors: Ngubane, Weekend Sehlulamanye
- Date: 2006
- Subjects: Rural schools -- South Africa -- KwaZulu Natal -- Case studies Rural schools -- Thailand -- Case studies Education, Rural -- South Africa -- KwaZulu Natal -- Case studies Black people -- Education -- South Africa School management and organization -- South Africa School principals -- South Africa Educational leadership -- South Africa Educational change -- South Africa Management -- Employee participation -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1607 , http://hdl.handle.net/10962/d1003489
- Description: The primary purpose of this research was to investigate the extent to which rural schools understand and perceive the concept of participative management. The concept of participative management has been viewed as an ideal style of leadership and management for school development purposes. In South Africa’s case, it is an educational policy which is expected to reign in all school management bodies. Many theorists envisaged participative management as enhancing active involvement of relevant stakeholders and it has been advocated by many scholars who believe it is the best leadership style in implementing democratic values to education, particularly South African rural education, which is still in a transitional stage. As an interpretive orientated study, this research had an interest in understanding the research participants’ subjective experiences as well as their general perception of participative management. As case-study-driven research, it sought to investigate their understanding of the concept in their natural setting. This included various meanings they aligned with and attached to participative management, their attitudes, their interpretations and feelings towards it. The study employed a focus group data gathering technique in collecting data. The findings of this study suggest that participative management has been embraced by rural school management to a certain extent. There are potentially positive aspects that have been brought by participative management to the school, namely, shared vision, common goals, shared decision-making and general involvement of relevant stakeholders. However, the study has depicted a lack of ethical values on the side of some stakeholders and this hinders the smooth implementation of participative management. The study has also revealed that there are challenges facing rural schools in terms of parental involvement in school governance. Challenges such as lack of commitment to the school, illiteracy among adults and communication breakdown between the school and its parents are still rife in rural schools. Besides these challenges, the blood of participative management is flowing steadily in the veins of the rural school communities.
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An investigation into the neuroprotective effects of dehydroepiandrosterone
- Authors: Palvie, Stefanie Michelle
- Date: 2006
- Subjects: Aging -- Physiological aspects , Nervous system -- Degeneration -- Treatment , Steroid hormones , Dehydroepiandrosterone , Dehydroepiandrosterone -- Therapeutic use , Neurosciences , Neuroanatomy , Apoptosis , Pineal gland -- Physiology , Neurotoxic agents , Free radicals (Chemistry) -- Physiological effect
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3782 , http://hdl.handle.net/10962/d1003260 , Aging -- Physiological aspects , Nervous system -- Degeneration -- Treatment , Steroid hormones , Dehydroepiandrosterone , Dehydroepiandrosterone -- Therapeutic use , Neurosciences , Neuroanatomy , Apoptosis , Pineal gland -- Physiology , Neurotoxic agents , Free radicals (Chemistry) -- Physiological effect
- Description: Dehydroepiandrosterone, a C-19 steroid, is found endogenously with the highest circulating serum levels. It is converted to important steroids such as the sex hormones oestrogen and testosterone. DHEA has come under the spotlight as a purported “fountain of youth” due to its well-characterised age-related decline. The supplementation of DHEA in both the elderly and those with a pathophysiological deficiency has been shown to be of benefit, particularly with regard to wellbeing and depression. The role of DHEA in the periphery has not been elucidated beyond its role as a precursor hormone in sex steroid biosynthesis, though it has been established as a neuroactive neurosteroid, capable of exerting neuroprotective effects in the brain. Since the importance of free radicals in aging and neurodegeneration is well established, investigations were conducted on the ability of DHEA to inhibit free radical generation or scavenge existing free radicals. DHEA was able to significantly inhibit quinolinic acid-induced lipid peroxidation, a measure of membrane damage, over a range of concentrations, although the reduction did not appear to be dose-dependent. This was observed in both in vitro and in vivo studies. Thus, the ability of a compound to reduce the degree of lipid peroxidation may indicate its value as a neuroprotectant. However, DHEA did not significantly reduce cyanide induced generation of the superoxide free radical, suggesting that DHEA is not an effective free radical scavenger of the superoxide anion and that the reduction in lipid peroxidation does not occur through a scavenging mechanism. Apoptosis is a physiological process which is necessary for development and homeostasis. However, this form of programmed cell death can be initiated through various mechanisms and too much apoptotic cell death results in deleterious effects in the body. DHEA was shown not to induce apoptosis. Even the lowest concentration of DHEA investigated in this thesis shows a remarkable decrease in the degree of apoptosis caused by intrahippocampal chemical insult by the neurotoxin quinolinic acid. Cresyl violet was used to visualise tissue for histological examination which revealed that DHEA is able to preserve the normal healthy morphology of hippocampal cells which have been exposed to quinolinic acid. Cells maintained their integrity and showed little evidence of swelling associated with necrosis. Organ culture studies were performed by assessing the impact of DHEA on several pineal metabolites. The study revealed that DHEA exerted an effect on the metabolism of indoleamines in the pineal gland. Melatonin, the chief pineal hormone, did not appear to be affected while the concentrations of N-acetylserotonin, serotonin and methoxytryptamine showed significant alterations. Thus, the neuroprotective mechanism of DHEA does not appear to be mediated by an increase in the presence of melatonin. The biological importance of metal ions in neurodegeneration is also well established and thus the potential interaction between DHEA and metal ions was considered as a mechanism of action. Spectroscopic and electrochemical analyses were performed to determine whether DHEA is able to interact with metal ions as a ligand. These reveal that DHEA does not form a strong bond with the metals investigated, namely copper (II) and iron (III), but that a weak interaction is evident. These investigations were conducted in a rodent model, which has neither large amounts of endogenous DHEA, nor the enzymatic infrastructure present in humans. Thus, the theory that DHEA exerts its effects through downstream metabolic products is unlikely. However, these investigations reveal that there is merit in the statement that DHEA itself is a neuroprotective molecule, and confirm that the further investigation of DHEA is an advisable strategy in the war against neurodegeneration and aging.
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An investigation into the neuroprotective effects of estrogen and progesterone in a model of homocysteine-induced neurodegeration
- Authors: Wu, Wing Man
- Date: 2006
- Subjects: Homocysteine , Estrogen , Estrogen -- Therapeutic use , Progesterone , Hormone receptors , Methyl aspartate , Oxidative stress , Alzheimer's disease -- Treatment , Nervous system -- Degeneration -- Prevention
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3806 , http://hdl.handle.net/10962/d1003284 , Homocysteine , Estrogen , Estrogen -- Therapeutic use , Progesterone , Hormone receptors , Methyl aspartate , Oxidative stress , Alzheimer's disease -- Treatment , Nervous system -- Degeneration -- Prevention
- Description: Homocysteine (Hcy) is a sulfur containing amino acid and is a potent neurotoxin. It has been shown that elevated levels of Hcy, termed hyperhomocysteinemia, plays a role in the pathologies of Alzheimer’s disease (AD) and age-related cognitive decline. Hcy is a glutamate agonist, which causes in increase in Ca[superscript (2+)] influx via the activation of NMDA class of excitatory amino acid receptors, which results in neuronal cell death and apoptosis. Estrogen and progesterone are female hormones that are responsible for reproduction and maternal behaviour. However, in the last decade, it is evident that both female hormones have neuroprotective properties in many animal models of neurodegeneration. Collectively, both estrogen and progesterone reduce the consequences of the oxidative stress by enhancing the antioxidant defence mechanisms, reducing excitotoxicity by altering glutamate receptor activity and reducing the damage caused by lipid peroxidation. However, the mechanisms by which estrogen and progesterone provide such neuroprotection probably depend on the type and concentration of hormone present. Moreover, numerous studies have shown that hormone replacement therapy (HRT, estrogen and progestins) or estrogen-only replacement therapy (ERT) may prevent or delay the onset of AD and improve cognition for women with AD. Clinical trials have also shown that women taking HRT may modify the effects of Hcy levels on cognitive functioning. Oxidative stress increases in the aging brain and thus has a powerful effect on enhanced susceptibility to neurodegenerative disease. The detection and measurement of lipid peroxidation and superoxide anion radicals in the brain tissue supports the involvement of free radical reactions in neurotoxicity and in neurodegenerative disorders. The hippocampus is an important region of the brain responsible for the formation of memory. However, agents that induce stress in this area have harmful effects and could lead to dementia. This study aims to investigate and clarify the neuroprotective effects of estrogen and progesterone, using Hcy-induced neurodegenerative models. The initial studies demonstrate that estrogen and progesterone have the ability to scavenge potent free radicals. Histological studies undertaken reveal that both estrogen and progesterone protect against Hcy-induced neuronal cell death. In addition, immunohistochemical investigations show that Hcy-induced apoptosis in the hippocampus can be inhibited by both estrogen and progesterone. However, estrogen also acts at the NMDA receptor as an agonist, while progesterone blocks at the NMDA receptor. These mechanisms reduce the ability of Hcy to cause damage to neurons, since Hcy-induced neurotoxicity is dependent on the overstimulation of the NMDA receptor. SOD and GPx are important enzymatic antioxidants which can react with ROS and neutralize them before these inflict damage in the brain. Hcy can increase oxidative stress by inhibiting expression and function of these antioxidants. However, it has been shown that the antioxidant abilities of both estrogen and progesterone can up-regulate the activities of SOD and GPx. These results provide further evidence that estrogen and progesterone act as antioxidants and are free radical scavengers. The discovery of neuroprotective agents is becoming important as accumulating evidence indicates the protective role of both estrogen and progesterone in Hcy-induced neurodegeneration. Thus further work in clinical trials is needed to examine whether reducing Hcy levels with HRT can become the treatment of neurodegenerative disorders, such as Alzheimer’s disease.
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An investigation into the neuroprotective properties of acyclovir
- Authors: Müller, Adrienne Carmel
- Date: 2006
- Subjects: Acyclovir -- Therapeutic use , Acyclovir -- Physiological effect , Nervous system -- Degeneration -- Treatment , Memory disorders -- Treatment , Quinolinic acid
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3776 , http://hdl.handle.net/10962/d1003254 , Acyclovir -- Therapeutic use , Acyclovir -- Physiological effect , Nervous system -- Degeneration -- Treatment , Memory disorders -- Treatment , Quinolinic acid
- Description: Accumulating evidence suggests that quinolinic acid has a role to play in disorders involving impairment of learning and memory. In the present study, the effect of the guanosine analogue antiherpetic, acyclovir, on quinolinic acid-induced spatial memory deficits was investigated, as well as some of the mechanisms which underlie this effect. Behavioural studies using a Morris water maze show that post-treatment of rats with acyclovir significantly improves spatial memory deficits induced by intrahippocampal injections of quinolinic acid. Histological analysis of the hippocampi show that the effect of acyclovir is related to its ability to alleviate quinolinic acid-induced necrotic cell death, through interference with some of the mechanisms of neurodegeneration. However, acyclovir is unable to alter a quinolinic acid-induced increase in glutamate release in the rat hippocampus, even though it alleviates quinolinic acid induced oxidative stress by scavenging the superoxide anion in vitro and in vivo in whole rat brain and hippocampus respectively. Due to the inverse relationship which exists between superoxide anion and glutathione levels, acyclovir also curtails the quinolinic acid-induced decrease in hippocampal glutathione levels. Acyclovir suppresses quinolinic acid-induced lipid peroxidation in vitro and in vivo, in whole rat brain and hippocampus respectively, through its alleviation of oxidative stress and possibly through the binding of iron (II) and / or iron (III), preventing the participation and redox recycling of iron (II) in the Fenton reaction, which quinolinic acid is thought to enhance by weak binding of ferrous ions. This argument is further strengthened by the ability of the drug to suppress iron (II)-induced lipid peroxidation in vitro directly. Inorganic studies including ultraviolet and visible spectroscopy, electrochemistry and the ferrozine assay show that acyclovir binds to iron (II) and iron (III) and that quinolinic acid forms an easily oxidisable association with iron (II). Acyclovir inhibits the endogenous biosynthesis of quinolinic acid by inhibiting the activity of liver tryptophan-2,3-dioxygenase, intestinal indoleamine-2,3-dioxygenase and rat liver 3-hydroxyanthranillic acid oxygenase in vitro and in vivo, possibly through competitive inhibition of haeme, scavenging of superoxide anion and binding of iron (II) respectively. An inverse relationship exists between tryptophan-2,3-dioxygenase activity and brain serotonin levels. Acyclovir administration in rats induces a rise in forebrain serotonin and 5-hydroxyindole acetic acid and reduces the turnover of forebrain serotonin to 5-hydroxyindole acetic acid. Furthermore, it shows that acyclovir does not alter forebrain norepinephrine levels. The results of the pineal indole metabolism study show that acyclovir increases 5-hydroxytryptophol, N-acetylserotonin and the neurohormone melatonin, but decreases 5-hydroxyindole acetic acid. The results of this study show that acyclovir has some neuroprotective properties which may make it useful in the alleviation of the anomalous neurobiology in neurodegenerative disorders.
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An investigation into the neuroprotective properties of the non-steroidal anti-inflammatory agents tolmetin, sulindac and turmeric
- Authors: Dairam, Amichand
- Date: 2006
- Subjects: Nonsteroidal anti-inflammatory agents Antioxidants Tolmetin -- Therapeutic use Sulindac -- Therapeutic use Turmeric -- Therapeutic use Nervous system -- Degeneration -- Prevention Alzheimer's disease
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3752 , http://hdl.handle.net/10962/d1003230
- Description: Accumulating evidence suggests that anti-inflammatory agents and antioxidants have neuroprotective properties and may be beneficial in the treatment of neurodegenerative disorders. In the present study, the possible neuroprotective properties of tolmetin, sulindac and turmeric were investigated. The antioxidant effects of tolmetin and sulindac were determined by inducing free radical generation with quinolinic acid (QA), cyanide or iron (II) in rat brain homogenates or primary hippocampal neurons. Tolmetin and sulindac significantly reduce lipid peroxidation and scavenge the superoxide anion. Metal binding studies were conducted to determine whether metal chelation is a possible mechanism through which these agents reduce QA and iron (II)-induced lipid peroxidation. UV/VIS, infrared spectroscopy as well as electrochemical studies show that both agents bind to iron (II) and/or iron (III). Histological examination of the hippocampus showed that pre-treatment of animals with tolmetin or sulindac offers protection against intrahippocampal injections of QA. These agents also attenuate QA-induced apoptosis and reduce the loss of neurons in the hippocampus. The co-incubation of primary hippocampal neurons with the NSAIDS also enhanced cell viability which is significantly reduced by QA. Behavioural studies using a water maze showed that the treatment of animals after QA-induced neurotoxicity reduces QA-induced spatial memory loss. Tolmetin and sulindac also reduced glutathione depletion and protein oxidation in rat hippocampus. Both NSAIDS inhibit liver tryptophan 2,3-dioxygenase activity in vitro and in vivo and subsequently increased hippocampal serotonin levels. However, both NSAIDS also reduce dopamine levels in rat striatum. Tolmetin but not sulindac increased the synthesis of melatonin by the pineal gland. The active components of turmeric known as the curcuminoids were separated using preparative thin layer chromatography (TLC). The purity was confirmed by TLC, NMR and mass spectrometry. The environmental toxin lead, induces lipid peroxidation and reduces primary hippocampal neuronal viability. The co-incubation of the neurons with the curcuminoids significantly reduces lead-induced lipid peroxidation and enhances neuronal cell viability in the presence of lead. Lead-induced spatial memory deficit is also attenuated with curcumin, demethoxycurcumin but not bisdemethoxycurcumin. The curcuminoids also reduce lead-induced hippocampal glutathione depletion and protein oxidation. Metal binding studies show that the curcuminoids bind to lead and is another possible mechanism through which the curcuminoids reduce lead-induced neurotoxicity. The findings of this study indicate a possible role of tolmetin, sulindac and turmeric in neurodegenerative disorders such as Alzheimer’s disease. However, tolmetin and sulindac reduce dopamine levels.
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An investigation into the popularity of American action movies shown in informal video houses in Addis Ababa, Ethiopia
- Authors: Assefa, Emrakeb
- Date: 2006
- Subjects: Motion pictures -- Ethiopia , Mass media -- Ethiopia , Popular culture -- Ethiopia , Mass media and youth -- Ethiopia , Mass media and culture -- Ethiopia , Mass media -- Sociological aspects , Ethiopia -- History
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3418 , http://hdl.handle.net/10962/d1002871 , Motion pictures -- Ethiopia , Mass media -- Ethiopia , Popular culture -- Ethiopia , Mass media and youth -- Ethiopia , Mass media and culture -- Ethiopia , Mass media -- Sociological aspects , Ethiopia -- History
- Description: The early 1990s saw a major change in the Ethiopian history in so far as Ethiopian media consumption practices was concerned. With the change of government in 1991, the ‘Iron Curtail’ prohibiting the dissemination of Western symbolic products within the country was lifted which in turn led to a surge in demand for Western predominantly American media texts. In order to supply this new demand, informal video houses showing primarily American action movies were opened in Addis Ababa. There was a significant shift in Ethiopians’ films consumption practices which were previously limited to watching films produced by socialist countries mainly the former Soviet Union. This study set out to probe reasons for the attraction of American action movies shown in video-viewing houses in Addis Ababa, Ethiopia amongst the urban unemployed male youth. Particularly, it examines how the meanings produced by and embedded in the cultural industries of the West are appropriated in the day-to-day lives of the youth. The importance of video houses as a shared male cultural space for Ethiopian unemployed youth and the watching of American action movies in this space are the main entry and focus of this study. Using qualitative methods such as observation, in-depth interviews and focus group discussions, the study explores what happens in this cultural space and how one makes sense of the impact of American media on local audiences. The findings of the study point to the embeddedness of viewing practice in everyday life and the importance of local contexts in understanding text-reader interaction. This is shown by the male youth’s tendency to use media messages as a mode of escape and a symbolic distancing from their lived impoverished reality. The study also seeks to highlight that the video houses as cultural space have contributed to the creation of marginal male youth identities in the Ethiopian patriarchal society. As such, these and other findings, the study argues, highlight the deficiencies of the media imperialism thesis with its definitive claims for cultural homogenisation as effect of globalisation of media. As such, this study should be read as emphasising the capability of local audience groups in Third World country like Ethiopia to construct their own meanings and thus their own local cultures and identities, even in the face of their virtually complete dependence on the image flows distributed by the transnational culture industries.
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An investigation into the validity of life tables used for the calculation of personal injury damages
- Authors: Forshaw, Timothy James
- Date: 2006
- Subjects: Torts -- South Africa , Damages -- South Africa , Damages -- South Africa -- Accounting , Mortality -- Tables , Personal injuries -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:1077 , http://hdl.handle.net/10962/d1008371 , Torts -- South Africa , Damages -- South Africa , Damages -- South Africa -- Accounting , Mortality -- Tables , Personal injuries -- South Africa
- Description: Currently in South Africa when an individual is injured due to the acts of another they may claim damages for the losses which they may incur. These can be claimed from a variety of institutions, such as the Road Accident Fund, Workmen's compensation or an individual's private insurance. In all the afore-mentioned cases the calculation of damages are along the same lines, whereby the damages are quantified first, and thereafter reduced to reflect future possibilities that may occur. Traditionally future losses are reduced to reflect the possibility that the claimant may die at an age prior to the loss being incurred. To account for this risk awards for future losses are reduced using standard South African mortality tables. The set of tables currently being used were calculated from the 1985 South African census, and as such encapsulate the mortality of the population at that period. When the tables were calculated no reliable statistics were available for the Black population the result is that the tables currently being used do not contain a sample of the majority of the population. The thesis first examines, in detail, the calculation methods used to arrive at the value for damages to be awarded using the current set of life tables. Thereafter an analysis is conducted looking at differences between racial groups in the country and geographic locations, in order to uncover the mortality differences between groups to confirm or disprove the proposition that the exclusion of the Black population results in lower levels of mortality being reflected in the South African 1984-1986 life tables. This is accompanied by a review of mortality trenps in South African since 1986. Following from the findings of the expected increase in mortality since 1986, alternative life tables shall be used to show what impact these would have on the calculation of damages. Due to the fact that none of the alternatives return satisfactory results, structured settlements shall be reviewed to illustrate how the shortcomings of the lump sum approach can be circumvented, and altogether avoid the problems of out dated life tables being used as a basis for damage calculations. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
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An investigation of a framework for the implementation of service management in the information and communication technology sector
- Authors: Benyon, Robert Victor
- Date: 2006
- Subjects: Support services (Management) , Service industries -- Management , Information technology -- Management , Management information systems , Communication in management
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:1137 , http://hdl.handle.net/10962/d1002766 , Support services (Management) , Service industries -- Management , Information technology -- Management , Management information systems , Communication in management
- Description: Service Management (SM) is an integrated, cyclical and collaborative approach to the management of service requirements and levels. It involves the definition of client expectations, the satisfying of those expectations and the perpetual refining of the business agreement (Sturm 2001). SM in the ICT sector is a comprehensive process that extends beyond the development of Service Agreements (SAs). A number of identifiable steps constitute the progressive implementation of a managed services environment, the key components of which are a readiness to provide services, the accurate elicitation, management and satisfying of client requirements and the continual improvements to the business relationship. Unfortunately, a number of SM initiatives fail. These failures can be attributed to a lack of SM understanding, the absence of a fully implemented SM strategy, poor communication and people issues. This research describes an investigation of SM implementation. A number of recognised frameworks are explored and critically analysed. The common strengths of these frameworks and the results of an exploratory pilot study are used to construct an SM implementation framework. This framework is then tested empirically by means of an online survey, and revised in the light of the results of this survey. The framework comprises two distinct phases, namely a Foundation phase and a Managed Services phase. The Foundation phase comprises 8 critical preparatory activities that take a service provider to state of readiness to provide and manage ICT services. The Managed Services phase comprises 5 key cyclical steps for the management of ICT services, including Planning, Analysis, Design, Implementation and Review.
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An investigation of integrated development planning (IDP) as a mechanism for poverty alleviation in Grahamstown in the Makana Municipality, Eastern Cape, South Africa
- Authors: Alebiosu, Olumide Ademola
- Date: 2006
- Subjects: Makana Municipality , Local government -- South Africa -- Eastern Cape , Poor -- South Africa -- Eastern Cape , Poverty -- South Africa -- Eastern Cape , Poverty -- Government policy -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4841 , http://hdl.handle.net/10962/d1005517 , Makana Municipality , Local government -- South Africa -- Eastern Cape , Poor -- South Africa -- Eastern Cape , Poverty -- South Africa -- Eastern Cape , Poverty -- Government policy -- South Africa -- Eastern Cape
- Description: Poverty among individuals, households or communities is not a static condition. There are many factors which contribute to its causes and depth. In South Africa the economic gaps imposed by the previous apartheid government aggravated economic inequalities and caused considerable disparities, which has resulted in high unemployment rates. Inequalities were also manifest in the neglect of infrastructural and service provision as well in the effective absence of independent governance among some race group. This led to a call for pro-active initiatives by the post-1994 democratic government to remedy the living condition of the previously disadvantaged people. As part of its poverty relief drive the South African government has embarked on a series of developmental initiatives in bringing infrastructure related services to the poor and to reduce the enormous prevailing backlog, with the aim of increasing community participation, improving service delivery and promoting the upliftment of the lives of poor people through the medium of local governance. This study investigated the Integrated Development Planning, which has been undertaken in Grahamstown in the Makana Municipality in the Eastern Cape to respond to the prevailing poverty and underdevelopment among the poor communities. Relying on their developmental mandate to initiate and co-ordinate all development activities within their area of jurisdiction through the IDP, the Makana Municipality has drawn up a development strategic plan in conjunction with the local communities and with other stakeholders and organisations to identify and assess development backlogs within the communities with the aim of addressing such backlogs. This study revealed from the interviews conducted with some municipal personnel and questionnaires administered to sampled residents of Grahamstown that some faces of poverty, such as unemployment and lack of access to some of the most basic of infrastructure such as, sanitation facilities, water, electricity, formal house, education, security and recreation facilities are apparent in Grahamstown. However, the Makana Municipality through, the IDP has achieved some notable feats in the provision of providing some of the basic amenities such as water, housing, electricity and sanitation albeit at a slow rate. The mechanism of delivery is hampered by bureaucratic settings within government and the ambiguity attached to some of the projects. The service and infrastructural developments targeted towards the poor and the involvement of communities in the affairs of the local government might be seen as a partially panacea for poverty alleviation in South Africa. However the capacity of the local governments to effectively carry out this developmental challenge assignment might be a new twist in the developmental challenge facing local governments in South Africa. The thesis provides an overview of the Makana Municipality IDP and the degree to which is serving as one mechanism to address poverty in the Grahamstown urban area
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An investigation of the relationship between journalists and their news sources: a case study of The Post newspaper in Zambia
- Authors: Kabeta, Jacqueline Milambo
- Date: 2006
- Subjects: The Post (Zambia) , Newspapers -- Zambia , Journalism -- Zambia , Journalists -- Zambia , Reporters and reporting -- Zambia
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3438 , http://hdl.handle.net/10962/d1002892 , The Post (Zambia) , Newspapers -- Zambia , Journalism -- Zambia , Journalists -- Zambia , Reporters and reporting -- Zambia
- Description: Normative professional journalism and the need to re-evaluate the structural social context of journalism practice and its role in emerging democracies has led to the increased scrutiny of journalists and their relationship to news sources. This study conceptualises the relationship between journalists and news sources as a dual process of consensus and conflict of interests in the newsgathering practice in Zambia, an emerging democracy. The study suggests that journalists actively pursue powerful individuals in society such as those in government, pressure groups and business as news sources who have been available and suitable in the past. Journalists’ view of society as bureaucratically organised and the short turn-around time of news production are among the organisational factors attributed to this tendency. This study adopts a sociological approach to investigate the journalist-news source relationship at The Post, in Zambia, by factoring in the perspectives of social organisation of newswork and political economy. Whereas the social organisation perspective focuses on the organisational and occupational demands of journalists, political economy reinforces the larger context of journalist-news source interaction in a society. Additionally, the social constructivist theory, which is premised around the idea that the agenda and content of journalism production, is in part a product of non-journalistic social factors is useful in understanding the various influences on the relationship. The study investigates the nature of the journalist-news source relationship using two diametrically opposed views – the dominant (exchange) and competitive (adversarial) paradigms. This is aimed at establishing whether the relationship is an exchange or adversarial. While the latter relationship is common in liberal democracies where the media are seen as part of elite structures with considerable power on their own, the thinking is that inequalities in resource distribution and political power generate social tensions in developing countries that require media to be carefully managed. Using qualitative semi-structured interviews and observation methods, this study establishes that while the adversarial role has an attraction for the journalists investigated, the exchange model comes closest to describing the nature of relationship they share with their news sources.
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