A biography on inkosi Albert John Mvumbi Luthuli as an African intellectual
- Mngadi, Samkelo Ntobeko Vukani
- Authors: Mngadi, Samkelo Ntobeko Vukani
- Date: 2022-04-07
- Subjects: Luthuli, A J (Albert John), 1898-1967 , Luthuli, A J (Albert John), 1898-1967 Political and social views , Africans Intellectual life , South Africa History , South Africa Politics and government , African National Congress Biography , Apartheid South Africa , Political activists South Africa Biography , Intellectuals Political activity South Africa
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294493 , vital:57226
- Description: [Excerpt taken from Introduction] The purpose of this study is to take a look at one of these African leaders, inkosi Albert Luthuli through a biographical lens to assess whether he should be recognised as an African intellectual. Sifiso Mxolisi Ndlovu states that inkosi Luthuli is recognised as the father of South Africa’s non-racialism. He used his moral authority in a historic fashion to influence the liberation movement to adopt non-violent resistance. During his time as President-General, he became the beacon of non-violent resistance. As the president of the liberation organisation, he delivered speeches that steered the African National Congress (ANC) and the liberation movement when the State escalated its oppression against Africans. The State retaliated by deposing him as an elected Chief, imprisoned him, imposed multiple bans on him in attempts to silence him. His intellect proved to be a threat to the State. He spoke out boldly against the apartheid state and advocated for chiefs, African people, African women, sugar farmers, and all oppressed racial groups. Inkosi Luthuli used his speeches to deliver political concepts like non-racialism, multiracialism, African nationalism and democracy into the public space. He cemented ANC’s cooperation policy that created the environment for the existence of the Congress Alliance that produced the Freedom Charter. He spoke out against the oppression of not just South Africans but Africa and all oppressed groups internationally. He illustrated that he possessed geopolitics that would gain the attention of the world. He illustrated his geopolitics through his internationalism philosophy gained the international community’s attention. Inkosi Luthuli was revered and respected by his Groutville community, the African community, South Africans of all racial groups and the international community. His impact can be seen through him being the first African-born Nobel Peace Prize recipient. He pushed for the international community to place economic sanctions and believed that international sanctions were the appropriate non-violent method the global community could get involved in fighting apartheid.5 The purpose of this study will be to explore how a Christian Zulu Chief’s intellectual thinking was able to move South Africa towards a multiracial democracy using non-violent resistance as a strategy to gain Africa and the world’s attention—looking at him from the vantage point of being an African intellectual. , Thesis (MA) -- Faculty of Humanities, History, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Mngadi, Samkelo Ntobeko Vukani
- Date: 2022-04-07
- Subjects: Luthuli, A J (Albert John), 1898-1967 , Luthuli, A J (Albert John), 1898-1967 Political and social views , Africans Intellectual life , South Africa History , South Africa Politics and government , African National Congress Biography , Apartheid South Africa , Political activists South Africa Biography , Intellectuals Political activity South Africa
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294493 , vital:57226
- Description: [Excerpt taken from Introduction] The purpose of this study is to take a look at one of these African leaders, inkosi Albert Luthuli through a biographical lens to assess whether he should be recognised as an African intellectual. Sifiso Mxolisi Ndlovu states that inkosi Luthuli is recognised as the father of South Africa’s non-racialism. He used his moral authority in a historic fashion to influence the liberation movement to adopt non-violent resistance. During his time as President-General, he became the beacon of non-violent resistance. As the president of the liberation organisation, he delivered speeches that steered the African National Congress (ANC) and the liberation movement when the State escalated its oppression against Africans. The State retaliated by deposing him as an elected Chief, imprisoned him, imposed multiple bans on him in attempts to silence him. His intellect proved to be a threat to the State. He spoke out boldly against the apartheid state and advocated for chiefs, African people, African women, sugar farmers, and all oppressed racial groups. Inkosi Luthuli used his speeches to deliver political concepts like non-racialism, multiracialism, African nationalism and democracy into the public space. He cemented ANC’s cooperation policy that created the environment for the existence of the Congress Alliance that produced the Freedom Charter. He spoke out against the oppression of not just South Africans but Africa and all oppressed groups internationally. He illustrated that he possessed geopolitics that would gain the attention of the world. He illustrated his geopolitics through his internationalism philosophy gained the international community’s attention. Inkosi Luthuli was revered and respected by his Groutville community, the African community, South Africans of all racial groups and the international community. His impact can be seen through him being the first African-born Nobel Peace Prize recipient. He pushed for the international community to place economic sanctions and believed that international sanctions were the appropriate non-violent method the global community could get involved in fighting apartheid.5 The purpose of this study will be to explore how a Christian Zulu Chief’s intellectual thinking was able to move South Africa towards a multiracial democracy using non-violent resistance as a strategy to gain Africa and the world’s attention—looking at him from the vantage point of being an African intellectual. , Thesis (MA) -- Faculty of Humanities, History, 2022
- Full Text:
- Date Issued: 2022-04-07
Alien crosstalk
- Stuart-Watson, Andrew Joseph
- Authors: Stuart-Watson, Andrew Joseph
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , Short stories, South African (English) 21st century , South African essays (English) 21st century , American fiction History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294515 , vital:57228
- Description: Alien Crosstalk , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Stuart-Watson, Andrew Joseph
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , Short stories, South African (English) 21st century , South African essays (English) 21st century , American fiction History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294515 , vital:57228
- Description: Alien Crosstalk , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
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- Date Issued: 2022-04-07
Along the river that flowed south
- Authors: Mohlomi, Teboho Samson
- Date: 2022-04-07
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/234195 , vital:50171
- Description: Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Mohlomi, Teboho Samson
- Date: 2022-04-07
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/234195 , vital:50171
- Description: Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
Exploring black South African men’s lived experiences of being fathered
- Authors: Rasebitse, Karabo
- Date: 2022-04-07
- Subjects: Fatherhood South Africa , Fathers and sons South Africa Psychological aspects , Masculinity Social aspects South Africa , Hegemony South Africa , Social constructionism South Africa , Culture , Men, Black Attitudes South Africa
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294504 , vital:57227
- Description: There is a lack of research studies in South Africa that explore young men’s lived experiences of being fathered. The aim of this study focused on exploring how Black South African men construct and understand their own lived experiences of being fathered by their biological father. This research study is situated within a social constructionism methodology and theoretical framework. Data were collected using semi-structured interviews with young men between the ages of 18-24. Data were analysed using thematic analysis as a way of analysing participants’ stories. Three central themes with subthemes emerged. The main themes regarded the father behaviour, fatherly roles and participants’ constructions of fatherhood. The study argues that fatherhood is a social construct based on participants’ lived experiences. Participants in this research still view fatherhood from cultural discourses, such as the provider/protector and a moral guider/role to construct fatherhood. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Rasebitse, Karabo
- Date: 2022-04-07
- Subjects: Fatherhood South Africa , Fathers and sons South Africa Psychological aspects , Masculinity Social aspects South Africa , Hegemony South Africa , Social constructionism South Africa , Culture , Men, Black Attitudes South Africa
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294504 , vital:57227
- Description: There is a lack of research studies in South Africa that explore young men’s lived experiences of being fathered. The aim of this study focused on exploring how Black South African men construct and understand their own lived experiences of being fathered by their biological father. This research study is situated within a social constructionism methodology and theoretical framework. Data were collected using semi-structured interviews with young men between the ages of 18-24. Data were analysed using thematic analysis as a way of analysing participants’ stories. Three central themes with subthemes emerged. The main themes regarded the father behaviour, fatherly roles and participants’ constructions of fatherhood. The study argues that fatherhood is a social construct based on participants’ lived experiences. Participants in this research still view fatherhood from cultural discourses, such as the provider/protector and a moral guider/role to construct fatherhood. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
- Full Text:
- Date Issued: 2022-04-07
Gray
- Authors: Fouché, James De Clerque
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , Detective and mystery stories, South African (English) 21st century , South African fiction (English) 21st century , South African essays (English) 21st century , English fiction 20th century History and criticism , American fiction African American authors History and criticism , American fiction 20th century History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292715 , vital:57009
- Description: My thesis is a crime fiction novella. I’m moved by the idea of developing feasible, relatable characters with flaws – a staple of the crime fiction genre. I also appreciate how crime serves as a platform from which to launch into human drama, the way James Ellroy does in The Black Dahlia. While my protagonist endures trials on a near Jobian scale, the narrative meditates on the consequences of crime and conflict in a satirical way. Writers like Ross Macdonald, Raymond Chandler, Flannery O’Connor, China Miéville and Derek Raymond have inspired me with their sharp imagery and unconventional characterization techniques. These techniques accelerate the ease with which a reader can step into the shoes of any given narrator. Their writing is crisp, uncluttered and uncomplicated. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Fouché, James De Clerque
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , Detective and mystery stories, South African (English) 21st century , South African fiction (English) 21st century , South African essays (English) 21st century , English fiction 20th century History and criticism , American fiction African American authors History and criticism , American fiction 20th century History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292715 , vital:57009
- Description: My thesis is a crime fiction novella. I’m moved by the idea of developing feasible, relatable characters with flaws – a staple of the crime fiction genre. I also appreciate how crime serves as a platform from which to launch into human drama, the way James Ellroy does in The Black Dahlia. While my protagonist endures trials on a near Jobian scale, the narrative meditates on the consequences of crime and conflict in a satirical way. Writers like Ross Macdonald, Raymond Chandler, Flannery O’Connor, China Miéville and Derek Raymond have inspired me with their sharp imagery and unconventional characterization techniques. These techniques accelerate the ease with which a reader can step into the shoes of any given narrator. Their writing is crisp, uncluttered and uncomplicated. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
Hiding no scars
- Authors: Mhlongo, Sanele
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , South African poetry (English) 21st century , Interpersonal relations in literature , Diaries -- Authorship , South African essays (English) 21st century , Russian poetry 20th century History and criticism , South African fiction (English) 21st century History and criticism , Greek poetry History and criticism , German poetry 20th century History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294311 , vital:57190
- Description: My thesis is a collection of free-verse narrative and prose poetry focusing on rural life and people, as well as my personal relationships. Poetry through its play with language has the ability to say things with immediacy and allows unnoticed things to acquire relevance. It gives me a framework within which to express difficult themes such as family relationships, death, solitude, and poverty. In writing these poems I have drawn on the work of Constantine P. Cavafy, particularly the poems ‘Ithaka’, ‘The City’ and ‘As Much As You Can’ which showcase his consistently simple narrative style that covers profound subjects. I have also been influenced by Paul Celan’s poetry in his collection Breathturn Into Timestead where poems such as ‘Corona’, ‘In praise of remoteness’ and ‘Twelve Years’ demonstrate how poetry can have pace through tightly controlled yet experimental structure. I have also drawn on Anna Akhmatova’s symbolic poetry, specifically the poems ‘Now the pillow’s’, ‘He loved three things, alive’ and ‘Prologue’ from the selection Anna Akhmatova: Selected Poems which has its intention the re-creation of the past in the present. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Mhlongo, Sanele
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , South African poetry (English) 21st century , Interpersonal relations in literature , Diaries -- Authorship , South African essays (English) 21st century , Russian poetry 20th century History and criticism , South African fiction (English) 21st century History and criticism , Greek poetry History and criticism , German poetry 20th century History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294311 , vital:57190
- Description: My thesis is a collection of free-verse narrative and prose poetry focusing on rural life and people, as well as my personal relationships. Poetry through its play with language has the ability to say things with immediacy and allows unnoticed things to acquire relevance. It gives me a framework within which to express difficult themes such as family relationships, death, solitude, and poverty. In writing these poems I have drawn on the work of Constantine P. Cavafy, particularly the poems ‘Ithaka’, ‘The City’ and ‘As Much As You Can’ which showcase his consistently simple narrative style that covers profound subjects. I have also been influenced by Paul Celan’s poetry in his collection Breathturn Into Timestead where poems such as ‘Corona’, ‘In praise of remoteness’ and ‘Twelve Years’ demonstrate how poetry can have pace through tightly controlled yet experimental structure. I have also drawn on Anna Akhmatova’s symbolic poetry, specifically the poems ‘Now the pillow’s’, ‘He loved three things, alive’ and ‘Prologue’ from the selection Anna Akhmatova: Selected Poems which has its intention the re-creation of the past in the present. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
Individual decision-making and cooperation in freshwater fisheries management at the Somme River, northern France
- Authors: Khumalo, Brian
- Date: 2022-04-07
- Subjects: Fishery management France Somme River , Fisheries France Somme River , Human ecology France Somme River , Traditional ecological knowledge France Somme River , Decision making , Experimental economics , Recreation France Somme River
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294561 , vital:57233
- Description: Are altruistic individuals more likely to cooperate when exploiting common resources? This research study asks whether or not rates of human altruistic behaviour expressed by individual recreational fishers in interpersonal contexts at the Somme River, Amiens mirror those rates of altruism expressed in collective contexts concerning local fisheries resources. In a natural resources context, altruism manifests as a willingness by fishers to incur personal cost for common-pool resource benefit. Accordingly, it is understood that altruistic behaviour reflected collectively expresses itself as cooperation. The research study takes place in Northern France with the stated objectives to: 1) observe individual fishers’ altruistic propensities in interpersonal contexts involving other fishers, 2) observe individual rates of altruistic behaviour in collective contexts involving common fisheries resources and compare with those expressed interpersonally, and 3) investigate whether or not a local (informal) management system existed in the town of Amiens to better understand if informal tenure of water space influences altruistic behaviour or not. The research design consists of two components, one quantitative and one qualitative. The former employs two economic games; a Dictators Games (DG) and a Public Good Game (PGG) in service of the first and second research objectives, and the latter employs cognitive mapping and free-listing exercises in service of the third. Here economic games stand as proxies for real-world situations involving individual (DG) and collective (PGG) decision-making whereas the exercises seek to uncover local ecological knowledge (LEK). The results found that while individual recreational fishers demonstrated lower rates of interpersonal altruism overall, in a collective setting involving local fisheries resources the rate was higher, implying a greater willingness to incur personal cost. Ecological knowledge was high among experienced fishers, yet no knowledge pertaining to parallel management and or informal rules of exclusion or resource subtraction were observed, suggesting an informal management system did not exist. The study additionally documents freshwater biodiversity, providing an index of fish species present in the river collected from the free-listing exercises, categorized into native and non-native as the latter can negatively affect trophic systems and ecosystem processes. , Thesis (MSocSci) -- Faculty of Humanities, Anthropology, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Khumalo, Brian
- Date: 2022-04-07
- Subjects: Fishery management France Somme River , Fisheries France Somme River , Human ecology France Somme River , Traditional ecological knowledge France Somme River , Decision making , Experimental economics , Recreation France Somme River
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294561 , vital:57233
- Description: Are altruistic individuals more likely to cooperate when exploiting common resources? This research study asks whether or not rates of human altruistic behaviour expressed by individual recreational fishers in interpersonal contexts at the Somme River, Amiens mirror those rates of altruism expressed in collective contexts concerning local fisheries resources. In a natural resources context, altruism manifests as a willingness by fishers to incur personal cost for common-pool resource benefit. Accordingly, it is understood that altruistic behaviour reflected collectively expresses itself as cooperation. The research study takes place in Northern France with the stated objectives to: 1) observe individual fishers’ altruistic propensities in interpersonal contexts involving other fishers, 2) observe individual rates of altruistic behaviour in collective contexts involving common fisheries resources and compare with those expressed interpersonally, and 3) investigate whether or not a local (informal) management system existed in the town of Amiens to better understand if informal tenure of water space influences altruistic behaviour or not. The research design consists of two components, one quantitative and one qualitative. The former employs two economic games; a Dictators Games (DG) and a Public Good Game (PGG) in service of the first and second research objectives, and the latter employs cognitive mapping and free-listing exercises in service of the third. Here economic games stand as proxies for real-world situations involving individual (DG) and collective (PGG) decision-making whereas the exercises seek to uncover local ecological knowledge (LEK). The results found that while individual recreational fishers demonstrated lower rates of interpersonal altruism overall, in a collective setting involving local fisheries resources the rate was higher, implying a greater willingness to incur personal cost. Ecological knowledge was high among experienced fishers, yet no knowledge pertaining to parallel management and or informal rules of exclusion or resource subtraction were observed, suggesting an informal management system did not exist. The study additionally documents freshwater biodiversity, providing an index of fish species present in the river collected from the free-listing exercises, categorized into native and non-native as the latter can negatively affect trophic systems and ecosystem processes. , Thesis (MSocSci) -- Faculty of Humanities, Anthropology, 2022
- Full Text:
- Date Issued: 2022-04-07
Joice Mujuru and the Zanu-PF Women’s League 1973-2014: opportunities and limits of maternal dignity (musha mukadzi) and self-preservation
- Authors: Mataruse, Sisasenkosi
- Date: 2022-04-07
- Subjects: Mujuru, Amai Joice T R (Amai Joice Teurai Ropa) , ZANU Women's League , Women and democracy Zimbabwe , Women Political activity Zimbabwe , Political leadership Zimbabwe , Sexism in political culture Zimbabwe , Patriarchy Zimbabwe , Women Zimbabwe Social conditions , Maternal dignity (musha mukadzi)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292748 , vital:57012
- Description: The foundations of African feminisms are intertwined with the historical liberation of the African continent. Joice Mujuru’s five decades in Zimbabwean political parties are no different in showing the gendered nature of the fight against the intersectional oppressions of nation, race, class and gender. The research aimed to examine the political life of Joice Mujuru between 1973 and 2018 in various political roles and what this might mean for how women political leaders participate and make decisions as autonomous individuals within political parties in Zimbabwe. This study is a political biography of Joice Mujuru’s ideas and leadership in political parties in Zimbabwe since 1973, when she joined the Zimbabwe African National Union – Patriotic Front (ZANU-PF) as a guerilla of its military wing, the Zimbabwe African National Liberation Army (ZANLA). Mujuru was the only woman in the first ZANU-PF cabinet in 1980. She served the Zimbabwean government in different cabinet positions and became the first female vice-president in 2004, until her ousting in 2014. This study is based on an interview with Mujuru, and nine interviews with one Member of Parliament, two independent political party candidates, three academics, two CSO activists, the leader of LEAD political party in Zimbabwe and personal communication with a celebrated Zimbabwean writer. The study uses the concept of “patriarchal bargain” (Kandiyoti, 1988; Makhunga, 2016) and “femocracy” (Mama, 1995b) to show that Mujuru’s participation in political parties has been shaped by compromising and negotiating a complex web of patriarchal constraints for acceptance and respect. This study shows that wifehood and motherhood, the idea of musha mukadzi (‘woman as home’), stands out as a defining factor for Mujuru in her identity formation as a political party leader and how she views the roles of other women in Zimbabwean political parties and politics. I term this political identity maternal dignity, which is a collective set of ideas of maternal respect determining women’s participation in political parties. The study shows that Mujuru uses dominant ideas of maternal dignity as a tool of self-presentation and self-preservation to survive as a political leader. Mujuru’s expulsion from ZANU-PF and her subsequent leadership in other political parties demonstrates the ways in which maternal dignity limits women from shaping alternative ideas of leadership outside of respectable womanhood. Through a political biography of Mujuru, the study reaches the conclusion that post-independence Zimbabwe offers limited space for women’s leadership, whether those women have liberation history credentials or not. The strategy of maternal dignity that Mujuru has used to navigate her political career is a “patriarchal bargain” with limited possibilities for women’s meaningful participation, and the transformation of political parties and governance in Zimbabwe. , Thesis (MA) -- Faculty of Humanities, Political and International Studies, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Mataruse, Sisasenkosi
- Date: 2022-04-07
- Subjects: Mujuru, Amai Joice T R (Amai Joice Teurai Ropa) , ZANU Women's League , Women and democracy Zimbabwe , Women Political activity Zimbabwe , Political leadership Zimbabwe , Sexism in political culture Zimbabwe , Patriarchy Zimbabwe , Women Zimbabwe Social conditions , Maternal dignity (musha mukadzi)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292748 , vital:57012
- Description: The foundations of African feminisms are intertwined with the historical liberation of the African continent. Joice Mujuru’s five decades in Zimbabwean political parties are no different in showing the gendered nature of the fight against the intersectional oppressions of nation, race, class and gender. The research aimed to examine the political life of Joice Mujuru between 1973 and 2018 in various political roles and what this might mean for how women political leaders participate and make decisions as autonomous individuals within political parties in Zimbabwe. This study is a political biography of Joice Mujuru’s ideas and leadership in political parties in Zimbabwe since 1973, when she joined the Zimbabwe African National Union – Patriotic Front (ZANU-PF) as a guerilla of its military wing, the Zimbabwe African National Liberation Army (ZANLA). Mujuru was the only woman in the first ZANU-PF cabinet in 1980. She served the Zimbabwean government in different cabinet positions and became the first female vice-president in 2004, until her ousting in 2014. This study is based on an interview with Mujuru, and nine interviews with one Member of Parliament, two independent political party candidates, three academics, two CSO activists, the leader of LEAD political party in Zimbabwe and personal communication with a celebrated Zimbabwean writer. The study uses the concept of “patriarchal bargain” (Kandiyoti, 1988; Makhunga, 2016) and “femocracy” (Mama, 1995b) to show that Mujuru’s participation in political parties has been shaped by compromising and negotiating a complex web of patriarchal constraints for acceptance and respect. This study shows that wifehood and motherhood, the idea of musha mukadzi (‘woman as home’), stands out as a defining factor for Mujuru in her identity formation as a political party leader and how she views the roles of other women in Zimbabwean political parties and politics. I term this political identity maternal dignity, which is a collective set of ideas of maternal respect determining women’s participation in political parties. The study shows that Mujuru uses dominant ideas of maternal dignity as a tool of self-presentation and self-preservation to survive as a political leader. Mujuru’s expulsion from ZANU-PF and her subsequent leadership in other political parties demonstrates the ways in which maternal dignity limits women from shaping alternative ideas of leadership outside of respectable womanhood. Through a political biography of Mujuru, the study reaches the conclusion that post-independence Zimbabwe offers limited space for women’s leadership, whether those women have liberation history credentials or not. The strategy of maternal dignity that Mujuru has used to navigate her political career is a “patriarchal bargain” with limited possibilities for women’s meaningful participation, and the transformation of political parties and governance in Zimbabwe. , Thesis (MA) -- Faculty of Humanities, Political and International Studies, 2022
- Full Text:
- Date Issued: 2022-04-07
Praying mantis
- Authors: Kenene, Thobeka
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , South African fiction (English) 21st century , South African essays (English) 21st century , Portuguese fiction 20th century History and criticism , Russian fiction 20th century History and criticism , Zimbabwean fiction (English) 20th century History and criticism , American fiction 20th century History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292726 , vital:57010
- Description: (Prologue) I could only see in black and white as if I had travelled through time. I was the star of the medieval people who waited on me. The city was Johannesburg where strange faces called me a traitor because I was an educated black person. I hid between the skyscrapers and ran into a mirror image of myself as a man. “I write this book,” he said to his readers, “To invoke a yearning in our youth to awaken from slumber. To set examples for them to desist from characters like Velesazi and Nongendi, and imitate Nomsa and Themba. And also, to contribute to Xhosa literature.” He signed off by calling himself our servant. These are the words from the note my great-grandfather left me. We walked together across a barren field and past a graveyard. I was feeling tired and lost; I wanted to get home as fast as possible. We quickened our step and entered a church site. Inside the church were all my close relatives. I saw myself on stage looking down at them, and when I opened my mouth to sing, they began laughing at me. I imagined him in his 1917 suit, as a writer, penning down his first novel that is dedicated to his mother. His round cheeks enveloped in a haze of candle light. He visited my dream in 2012 and in the dream he asked me, “Do you see?” I said, “Yes, I see.” My great-grandfather hummed a song from his belly. I inhaled deeply into my belly and then exhaled a sound. Together we hummed this song that made everyone fall silent and listen. In the dream I could feel my lungs expanding and deflating along to the rhythm of the song. As my great-grandfather and I sang it, the night lamps shone brighter. I had become my great-grandfather, wearing his suit and black leather shoes. His friends were my friends. They turned and asked me what my clan name was. When I told them, they whispered something among themselves. One of them said to me, “Unogcwabevu.” I saw a white unknown woman who was afraid of me. I told her it is going to be okay, and that I would not harm her. But the colour of my skin frightened her. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Kenene, Thobeka
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , South African fiction (English) 21st century , South African essays (English) 21st century , Portuguese fiction 20th century History and criticism , Russian fiction 20th century History and criticism , Zimbabwean fiction (English) 20th century History and criticism , American fiction 20th century History and criticism
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292726 , vital:57010
- Description: (Prologue) I could only see in black and white as if I had travelled through time. I was the star of the medieval people who waited on me. The city was Johannesburg where strange faces called me a traitor because I was an educated black person. I hid between the skyscrapers and ran into a mirror image of myself as a man. “I write this book,” he said to his readers, “To invoke a yearning in our youth to awaken from slumber. To set examples for them to desist from characters like Velesazi and Nongendi, and imitate Nomsa and Themba. And also, to contribute to Xhosa literature.” He signed off by calling himself our servant. These are the words from the note my great-grandfather left me. We walked together across a barren field and past a graveyard. I was feeling tired and lost; I wanted to get home as fast as possible. We quickened our step and entered a church site. Inside the church were all my close relatives. I saw myself on stage looking down at them, and when I opened my mouth to sing, they began laughing at me. I imagined him in his 1917 suit, as a writer, penning down his first novel that is dedicated to his mother. His round cheeks enveloped in a haze of candle light. He visited my dream in 2012 and in the dream he asked me, “Do you see?” I said, “Yes, I see.” My great-grandfather hummed a song from his belly. I inhaled deeply into my belly and then exhaled a sound. Together we hummed this song that made everyone fall silent and listen. In the dream I could feel my lungs expanding and deflating along to the rhythm of the song. As my great-grandfather and I sang it, the night lamps shone brighter. I had become my great-grandfather, wearing his suit and black leather shoes. His friends were my friends. They turned and asked me what my clan name was. When I told them, they whispered something among themselves. One of them said to me, “Unogcwabevu.” I saw a white unknown woman who was afraid of me. I told her it is going to be okay, and that I would not harm her. But the colour of my skin frightened her. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
Sexual socialisation: young adult women storying how sexual activities were discussed in South African cultural contexts
- Authors: Ludidi, Zizipho
- Date: 2022-04-07
- Subjects: Socialization South Africa , Sex Social aspects South Africa , Young women Socialization South Africa , Young women Sexual behavior South Africa , Culture , Memory , Narrative inquiry (Research method)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292737 , vital:57011
- Description: Epidemics such as HIV/AIDS, unplanned pregnancy, gender-based violence and homophobia, in South Africa, have focused research on how young people learn about sex. This research has often focused on young girls from risk-saturated areas, and specific agents of socialisation, where they might learn about sex, such as parents, life orientation at schools, peers, media, and traditional cultural approaches. Using a narrative theoretical framework, through memory work, this study explored how black young adult women friends – who were university students – experienced forms of sexual socialisation, through various communication in South African cultural contexts. Findings from the thematic narrative analysis that was conducted demonstrated that sexual socialisation is a complex life-long process. This takes place through a collision of contradictory messages, from different agents of socialisation, in different cultural contexts. Themes were identified and organised to tell an overall sexual socialisation story that progressed through time, moving from a stage of perceived innocent oblivion, mixed messages in primary and high school, “liberal” university stories and the current stage of reauthoring stories. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Ludidi, Zizipho
- Date: 2022-04-07
- Subjects: Socialization South Africa , Sex Social aspects South Africa , Young women Socialization South Africa , Young women Sexual behavior South Africa , Culture , Memory , Narrative inquiry (Research method)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292737 , vital:57011
- Description: Epidemics such as HIV/AIDS, unplanned pregnancy, gender-based violence and homophobia, in South Africa, have focused research on how young people learn about sex. This research has often focused on young girls from risk-saturated areas, and specific agents of socialisation, where they might learn about sex, such as parents, life orientation at schools, peers, media, and traditional cultural approaches. Using a narrative theoretical framework, through memory work, this study explored how black young adult women friends – who were university students – experienced forms of sexual socialisation, through various communication in South African cultural contexts. Findings from the thematic narrative analysis that was conducted demonstrated that sexual socialisation is a complex life-long process. This takes place through a collision of contradictory messages, from different agents of socialisation, in different cultural contexts. Themes were identified and organised to tell an overall sexual socialisation story that progressed through time, moving from a stage of perceived innocent oblivion, mixed messages in primary and high school, “liberal” university stories and the current stage of reauthoring stories. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
- Full Text:
- Date Issued: 2022-04-07
The memory altar
- Alexander-McKenna, Hilary Jane
- Authors: Alexander-McKenna, Hilary Jane
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , South African fiction (English) 21st century , South African essays (English) 21st century , South African essays (English) History and criticism , South African fiction (English) History and criticism , Yuknavitch, Lidia Criticism and interpretation , American fiction Criticism and interpretation , COVID-19 (Disease) in literature
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/263533 , vital:53636
- Description: My thesis is a novella that casts a sideways glance at the real world that at times seems stranger than fiction. The novella is written as a work of realistic fiction, with a plot, characters, timelines and location placed in present time, reflecting real current events. My work is strongly influenced by writers such as Ivan Vladislavić whose Portrait with Keys uses a slice of life narrative voice that observes overlays of public and private realities; Marguerite Duras’ use of cinematic storytelling and deeply personal exposure in The Lover and Yann Andréa Steiner; Kate Zambreno’s depiction of inner chaos against the chaos of an anonymous city in Green Girl; Otessa Moshfegh who makes the minutiae of the day-to-day seem significant in My Year of Rest and Relaxation; and Samuel Beckett’s finely crafted streams of consciousness, in his works of prose and drama, revealing the intimate perspectives of insiders. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Alexander-McKenna, Hilary Jane
- Date: 2022-04-07
- Subjects: Creative writing (Higher education) South Africa , Diaries -- Authorship , South African fiction (English) 21st century , South African essays (English) 21st century , South African essays (English) History and criticism , South African fiction (English) History and criticism , Yuknavitch, Lidia Criticism and interpretation , American fiction Criticism and interpretation , COVID-19 (Disease) in literature
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/263533 , vital:53636
- Description: My thesis is a novella that casts a sideways glance at the real world that at times seems stranger than fiction. The novella is written as a work of realistic fiction, with a plot, characters, timelines and location placed in present time, reflecting real current events. My work is strongly influenced by writers such as Ivan Vladislavić whose Portrait with Keys uses a slice of life narrative voice that observes overlays of public and private realities; Marguerite Duras’ use of cinematic storytelling and deeply personal exposure in The Lover and Yann Andréa Steiner; Kate Zambreno’s depiction of inner chaos against the chaos of an anonymous city in Green Girl; Otessa Moshfegh who makes the minutiae of the day-to-day seem significant in My Year of Rest and Relaxation; and Samuel Beckett’s finely crafted streams of consciousness, in his works of prose and drama, revealing the intimate perspectives of insiders. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
- Full Text:
- Date Issued: 2022-04-07
Therapy drop-out: a descriptive case study of an imperfect sand-play therapy process with an aggressive 12 year old boy
- Authors: Fouche, Aimee Louise
- Date: 2022-04-07
- Subjects: Psychotherapy Failure , Psychotherapy Outcome assessment , Psychotherapy , Aggressiveness in children , Sandplay Therapeutic use , Play therapy , Conduct disorders in children , Boys Psychology
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292704 , vital:57008
- Description: This case study sought to document an imperfect sandplay therapy process with an aggressive 12 year old male. Premature abscondment is a recognised issue in child and adolescent therapy. Extra-therapeutic factors like social support from family and friends have been found to be determinants of child psychotherapy outcomes. There is a significant gap in case study research documenting a failed child therapy process. This research aims to address the omission by using qualitative methods to elicit a nuanced account of such a process. The results of thematic analysis found that parents played a crucial role in the failure of the process. Not only were they instrumental in stopping therapy attendance but their disengaged attitudes infiltrated into the child’s process. Implications for clinical practice were discussed and recommendations were made for more documentation of failed therapy processes. This case study hopes to form part of the ground work for future investigations. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
- Full Text:
- Date Issued: 2022-04-07
- Authors: Fouche, Aimee Louise
- Date: 2022-04-07
- Subjects: Psychotherapy Failure , Psychotherapy Outcome assessment , Psychotherapy , Aggressiveness in children , Sandplay Therapeutic use , Play therapy , Conduct disorders in children , Boys Psychology
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/292704 , vital:57008
- Description: This case study sought to document an imperfect sandplay therapy process with an aggressive 12 year old male. Premature abscondment is a recognised issue in child and adolescent therapy. Extra-therapeutic factors like social support from family and friends have been found to be determinants of child psychotherapy outcomes. There is a significant gap in case study research documenting a failed child therapy process. This research aims to address the omission by using qualitative methods to elicit a nuanced account of such a process. The results of thematic analysis found that parents played a crucial role in the failure of the process. Not only were they instrumental in stopping therapy attendance but their disengaged attitudes infiltrated into the child’s process. Implications for clinical practice were discussed and recommendations were made for more documentation of failed therapy processes. This case study hopes to form part of the ground work for future investigations. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
- Full Text:
- Date Issued: 2022-04-07
A conceptual IT governance framework to guide the development of interoperable health information systems
- Authors: Matshaba, Lebogang
- Date: 2022-04-06
- Subjects: Information technology Management , Information technology Management Standards , Information technology Security measures , Medical informatics South Africa , Medical records Data processing , Internetworking (Telecommunication) , National health insurance South Africa , Design Science Research (DSR)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284570 , vital:56075
- Description: In light of changing health needs, health information systems are presented with a plethora of challenges. For instance, the rise of COVID-19 in the past year has led to the discourse on the strength of current health systems to support health needs and the readiness for the National Health Insurance in South Africa. In addition to operating in resource-constrained environments, the lack of synchrony between health information systems across health facilities led to the fragmentation of health information and diminished access to quality healthcare. This research, following the Design Science Research Methodology (DSRM) process, developed an IT governance conceptual framework (HISIG-CF), to inform the interoperability of health information systems. The HISIG-CF is developed from literature and qualitative data collected using an expert reviews method from practitioners in the healthcare sector who evaluated the constructs of the HISIG-CF. Thematic analysis and hermeneutics were used to analyse and interpret the data. The results revealed a need for more guidance to inform interoperability interventions and strengthen current health information systems. The contribution of this study is the HISIG-CF which is deemed relevant and potentially fit-for-purpose to improve health information systems interoperability within the healthcare sector in South Africa. , Thesis (MCom) -- Faculty of Commerce, Department of Information Systems, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Matshaba, Lebogang
- Date: 2022-04-06
- Subjects: Information technology Management , Information technology Management Standards , Information technology Security measures , Medical informatics South Africa , Medical records Data processing , Internetworking (Telecommunication) , National health insurance South Africa , Design Science Research (DSR)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284570 , vital:56075
- Description: In light of changing health needs, health information systems are presented with a plethora of challenges. For instance, the rise of COVID-19 in the past year has led to the discourse on the strength of current health systems to support health needs and the readiness for the National Health Insurance in South Africa. In addition to operating in resource-constrained environments, the lack of synchrony between health information systems across health facilities led to the fragmentation of health information and diminished access to quality healthcare. This research, following the Design Science Research Methodology (DSRM) process, developed an IT governance conceptual framework (HISIG-CF), to inform the interoperability of health information systems. The HISIG-CF is developed from literature and qualitative data collected using an expert reviews method from practitioners in the healthcare sector who evaluated the constructs of the HISIG-CF. Thematic analysis and hermeneutics were used to analyse and interpret the data. The results revealed a need for more guidance to inform interoperability interventions and strengthen current health information systems. The contribution of this study is the HISIG-CF which is deemed relevant and potentially fit-for-purpose to improve health information systems interoperability within the healthcare sector in South Africa. , Thesis (MCom) -- Faculty of Commerce, Department of Information Systems, 2022
- Full Text:
- Date Issued: 2022-04-06
A laboratory simulation investigating the impact of sunglass tint on the catching performance of cricket fielders
- Authors: Nellemann, Stacy Amanda
- Date: 2022-04-06
- Subjects: Sunglasses , Cricket Physiological aspects , Cricket players , Glare , Vision , Contrast sensitivity (Vision) , Fielders (Cricket)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291281 , vital:56839
- Description: Background: Sunglasses are popularly worn by outdoor athletes such as cricketers. They are primarily worn to preserve ocular health due to the length of time exposed to the sun’s glare on the field. More recently, sunglasses are now worn for their purported performance-enhancing benefits supposedly allowing athletes to “see clearly, react faster and perform with confidence”. Fielders typically wear sunglasses, but it is rare to see the bowler or the batter wearing sunglasses although they are exposed to the same conditions. If sunglasses provide visual clarity for better reaction time, it is assumed this would also be beneficial for both batsmen and bowlers alike. It is interesting that although fielding plays a key role in the winning of a match, it has received very little research in comparison to the areas of batting and bowling. Research concerning sunglasses in the past has been concerned with its effect on ocular parameters such as colour vision and contrast sensitivity, with minimal research on their effect on performance, specifically on how different colour tints may affect performance such as catching in fielding. Objective: The purpose of this study was to compare the catching performance of fielders when wearing three different colour tints of sunglasses. Methods: Thirty male cricketers currently playing for Rhodes University or country districts sides in Makhanda, South Africa, who were non-habitual sunglass wearers were recruited for this study. An optician administered a pre-screening test to ensure participants did not have any visual defects that would affect the results, determining who was eligible to continue with the research project. Twenty-five participants qualified with a further four withdrawing during the experimentation phase due to personal reasons. Eligible participants were required to complete four testing sessions on separate days thereafter in which they wore a different colour tint at each session (clear, blue, G30 and red). These tints were randomised among participants. Participants were required to catch 18 balls projected from a bowling machine in each session. The number of balls caught as well as the quality of catch was recorded. At the end of the fourth session, participants were presented with a questionnaire investigating their subjective experience of the protocol and preference for any particular colour of lens. Results: Statistically significant results were found between the different colour lenses for the ocular parameters of contrast sensitivity and stereopsis tested by the optician. The red lens was found to be the best for contrast sensitivity with the blue lens performing the worst on this test. With regard to stereopsis, the G30 lens was the worst, with the red lens performing the best. The performance measures resulted in no significant difference between the different colour lenses both concerning the total number of catches taken as well as the quality of catch taken. The same result was found irrespective of the colour of lens used in each session. Data gathered from the questionnaire regarding visual comfort and target visibility resulted in the red lens being rated statistically worse than the other three conditions. In terms of personal preference, the G30 lens was rated statistically as the best coloured lens. Conclusion: It can be concluded that objectively there is no difference in performance between the three coloured lenses. Although from an ocular perspective, the red lens was expected to perform the best in terms of catching performance, there was no difference. Subjectively there was a strong preference among the players for the G30 lens with players strongly disliking the red lens. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Nellemann, Stacy Amanda
- Date: 2022-04-06
- Subjects: Sunglasses , Cricket Physiological aspects , Cricket players , Glare , Vision , Contrast sensitivity (Vision) , Fielders (Cricket)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291281 , vital:56839
- Description: Background: Sunglasses are popularly worn by outdoor athletes such as cricketers. They are primarily worn to preserve ocular health due to the length of time exposed to the sun’s glare on the field. More recently, sunglasses are now worn for their purported performance-enhancing benefits supposedly allowing athletes to “see clearly, react faster and perform with confidence”. Fielders typically wear sunglasses, but it is rare to see the bowler or the batter wearing sunglasses although they are exposed to the same conditions. If sunglasses provide visual clarity for better reaction time, it is assumed this would also be beneficial for both batsmen and bowlers alike. It is interesting that although fielding plays a key role in the winning of a match, it has received very little research in comparison to the areas of batting and bowling. Research concerning sunglasses in the past has been concerned with its effect on ocular parameters such as colour vision and contrast sensitivity, with minimal research on their effect on performance, specifically on how different colour tints may affect performance such as catching in fielding. Objective: The purpose of this study was to compare the catching performance of fielders when wearing three different colour tints of sunglasses. Methods: Thirty male cricketers currently playing for Rhodes University or country districts sides in Makhanda, South Africa, who were non-habitual sunglass wearers were recruited for this study. An optician administered a pre-screening test to ensure participants did not have any visual defects that would affect the results, determining who was eligible to continue with the research project. Twenty-five participants qualified with a further four withdrawing during the experimentation phase due to personal reasons. Eligible participants were required to complete four testing sessions on separate days thereafter in which they wore a different colour tint at each session (clear, blue, G30 and red). These tints were randomised among participants. Participants were required to catch 18 balls projected from a bowling machine in each session. The number of balls caught as well as the quality of catch was recorded. At the end of the fourth session, participants were presented with a questionnaire investigating their subjective experience of the protocol and preference for any particular colour of lens. Results: Statistically significant results were found between the different colour lenses for the ocular parameters of contrast sensitivity and stereopsis tested by the optician. The red lens was found to be the best for contrast sensitivity with the blue lens performing the worst on this test. With regard to stereopsis, the G30 lens was the worst, with the red lens performing the best. The performance measures resulted in no significant difference between the different colour lenses both concerning the total number of catches taken as well as the quality of catch taken. The same result was found irrespective of the colour of lens used in each session. Data gathered from the questionnaire regarding visual comfort and target visibility resulted in the red lens being rated statistically worse than the other three conditions. In terms of personal preference, the G30 lens was rated statistically as the best coloured lens. Conclusion: It can be concluded that objectively there is no difference in performance between the three coloured lenses. Although from an ocular perspective, the red lens was expected to perform the best in terms of catching performance, there was no difference. Subjectively there was a strong preference among the players for the G30 lens with players strongly disliking the red lens. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
- Full Text:
- Date Issued: 2022-04-06
A novel o/w microemulsion fixed dose combination of efavirenz, emtricitabine and tenofovir disoproxil fumarate: development and characterisation
- Authors: Mabvira, Samantha
- Date: 2022-04-06
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/232925 , vital:50038
- Description: Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Mabvira, Samantha
- Date: 2022-04-06
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/232925 , vital:50038
- Description: Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2022
- Full Text:
- Date Issued: 2022-04-06
A retrospective study of antimicrobial prescribing practices in paediatric patients at the Mahalapye District Hospital, Central Botswana
- Authors: Nyawera, Angella
- Date: 2022-04-06
- Subjects: Anti-infective agents Botswana Mahalapye , Drug resistance , Pediatrics Botswana Mahalapye , Pediatrics Formulae, receipts, prescriptions , Drugs Prescribing Moral and ethical aspects
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/290682 , vital:56774
- Description: Background: The development of antimicrobial resistance (AMR) has been linked to the increased and irrational use of antimicrobial medicines. The aim of this study was to investigate the antimicrobial prescribing practices in the paediatric medical ward at Mahalapye District Hospital (MDH) in Botswana and to determine whether antimicrobial stewardship (AMS) measures were being implemented at the hospital. Methods A cross-sectional, descriptive, mixed methods, observational approach was taken in this study. The study site was the paediatric medical ward (PMW) at MDH. Information about the antimicrobials prescribed for paediatric patients from January 2018 to December 2018 was collected from patients’ information files and compared to national antimicrobial prescribing guidelines to determine prescribers’ adherence. Qualitative semi-structured interviews were conducted with members of staff at MDH to determine whether antimicrobial stewardship (AMS) measures were adopted at the hospital. Results A total of 278 patients were included in this study, 12 of these were admitted twice during the study period. In total 290 admissions were analysed, with 659 antimicrobial medicines prescribed. The most common diagnoses were pneumonia (36.9%), acute gastroenteritis (20.7%), upper respiratory tract infections (3.4%), and bronchiolitis (3.1%). The most prescribed antimicrobials were ampicillin (21.4%), gentamicin (21.2%), and cefotaxime (8.3%). Adherence to guidelines was relatively good, with 82.7% of antimicrobials prescribed for the patients in the study having been prescribed in compliance with the national prescribing guidelines. The semi-structured interviews highlighted the fact that staff knew about AMS and AMR in general, however awareness of an AMS committee at MDH varied. The AMS committee was a multidisciplinary committee, which was a subcommittee of the Drugs and Therapeutics Committee (DTC). Discussion and Conclusion The results suggest that adherence to prescribing guidelines was relatively high compared to other paediatric antimicrobial utilisation studies in African countries. Prescribing of antimicrobial medicines was consistent with other African countries. The long period of time that it takes for microbiological test results to become available means that most prescribers rely on empirical prescribing. The antimicrobial committee is a multidisciplinary committee with defined roles for its members, consistent with international guidelines for implementing an AMS committee at a hospital. , Thesis (MPharm) -- Faculty of Pharmacy, Pharmacy, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Nyawera, Angella
- Date: 2022-04-06
- Subjects: Anti-infective agents Botswana Mahalapye , Drug resistance , Pediatrics Botswana Mahalapye , Pediatrics Formulae, receipts, prescriptions , Drugs Prescribing Moral and ethical aspects
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/290682 , vital:56774
- Description: Background: The development of antimicrobial resistance (AMR) has been linked to the increased and irrational use of antimicrobial medicines. The aim of this study was to investigate the antimicrobial prescribing practices in the paediatric medical ward at Mahalapye District Hospital (MDH) in Botswana and to determine whether antimicrobial stewardship (AMS) measures were being implemented at the hospital. Methods A cross-sectional, descriptive, mixed methods, observational approach was taken in this study. The study site was the paediatric medical ward (PMW) at MDH. Information about the antimicrobials prescribed for paediatric patients from January 2018 to December 2018 was collected from patients’ information files and compared to national antimicrobial prescribing guidelines to determine prescribers’ adherence. Qualitative semi-structured interviews were conducted with members of staff at MDH to determine whether antimicrobial stewardship (AMS) measures were adopted at the hospital. Results A total of 278 patients were included in this study, 12 of these were admitted twice during the study period. In total 290 admissions were analysed, with 659 antimicrobial medicines prescribed. The most common diagnoses were pneumonia (36.9%), acute gastroenteritis (20.7%), upper respiratory tract infections (3.4%), and bronchiolitis (3.1%). The most prescribed antimicrobials were ampicillin (21.4%), gentamicin (21.2%), and cefotaxime (8.3%). Adherence to guidelines was relatively good, with 82.7% of antimicrobials prescribed for the patients in the study having been prescribed in compliance with the national prescribing guidelines. The semi-structured interviews highlighted the fact that staff knew about AMS and AMR in general, however awareness of an AMS committee at MDH varied. The AMS committee was a multidisciplinary committee, which was a subcommittee of the Drugs and Therapeutics Committee (DTC). Discussion and Conclusion The results suggest that adherence to prescribing guidelines was relatively high compared to other paediatric antimicrobial utilisation studies in African countries. Prescribing of antimicrobial medicines was consistent with other African countries. The long period of time that it takes for microbiological test results to become available means that most prescribers rely on empirical prescribing. The antimicrobial committee is a multidisciplinary committee with defined roles for its members, consistent with international guidelines for implementing an AMS committee at a hospital. , Thesis (MPharm) -- Faculty of Pharmacy, Pharmacy, 2022
- Full Text:
- Date Issued: 2022-04-06
Academic or ‘zoombie’? Characterizing sleep quality, work and lifestyle behaviours among a cohort of South African academic staff during the Covid-19 pandemic
- Authors: Le Grange, Sarah-Ann
- Date: 2022-04-06
- Subjects: Sleep-wake cycle South Africa Eastern Cape , Sleep Physiological aspects , Lifestyles Health aspects South Africa Eastern Cape , COVID-19 Pandemic, 2020- Influence , Work environment Psychological aspects , Work environment Physiological aspects , College teachers Workload South Africa Eastern Cape , Pittsburgh Sleep Quality Index (PSQI)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291099 , vital:56818
- Description: Working in academe is characterized by high work demands, long and late working hours and balancing multiple roles. This often leaves academic staff (interchangeably referred to as ‘academics’ and ‘staff’) with limited time to prioritize adequate rest and sleep. While sufficient sleep is important for general well-being and work performance, it may be important for academics given the cognitive and interactive nature of their work. However, limited research has characterized sleep behaviours and sleep quality in academic staff globally and specifically in South Africa (SA). Further, research shows that academics from different academic ranks and genders differ in their work experiences but less is known about whether these factors affect their sleep and lifestyle factors. Over and above the demands of academic work, the current study was conducted during COVID-19, which saw unprecedented change in workloads for academic staff due to online teaching and learning. Additionally, the pandemic has been associated with poorer sleep quality and lifestyle behaviours in the general population, but very few studies have explored this in the context of academics. Thus, this study aimed to characterize the sleep quality, work and lifestyle factors among academics from a university in the Eastern Cape province of SA and determine the effects of gender and academic rank on these measures. Additionally, the study aimed to determine the impact of COVID-19 on sleep and work-related factors of this group. This study adopted a cross-sectional design and made use of an online questionnaire that was distributed to all academics employed at the institution via email. The data collection occurred over an 8-week testing period between August and September of 2020. The questionnaire explored sociodemographic, work and lifestyle characteristics, while the characteristics of sleep and sleep quality were explored with the Pittsburgh Sleep Quality Index (PSQI). Additionally, an open-ended section was included to determine the impact of COVID-19-related changes on sleep and work. The questionnaire responses were analyzed with descriptive and inferential statistics and the open-ended questions were analyzed with thematic analyses. A total of 84 respondents completed the questionnaire. On average, sleep quality was poor (global score of 7.09 ± 3.8), the reported sleep duration was short (6.41 ± 1.06 hrs) and the group was classified as overweight according to median BMI (26.67 [23.8-2 29.45] kg/m2). Over a third (35.71%) of academic staff reported not meeting physical activity guidelines and reported using screens one hour prior to bed every night during the week (76.19%) and the weekend (67.88%). Staff also worked long total weekly work hours (54.25 ± 11). Female academics had a poorer sleep quality (p = 0.035), spent a longer time in bed (p = 0.04), experienced more bad dreams (p = <0.01), had their last serving of alcohol earlier (p = 0.04) and worked less weekday (p = 0.04) and less total weekly (p = 0.02) hours compared to male academics. Professorship-level academics were significantly older than junior- and senior-level academics (p = <0.01) while senior-level academics had a poorer PSQI compared to professorship-level academics (p = 0.03). The thematic analysis showed that home environment, neighbourhood noise, work and mental health were the main emerging factors that disturbed sleep. The thematic analysis showed that, in relation to the impact of COVID19, sleep schedules changed and sleep duration and sleep quality improved or got worse. Respondents reported their work hours increasing, work schedules becoming less routine while working from home, dealing with the challenges of working online and experiencing worry, stress and anxiety due to the pandemic. The study highlights that, in the context of lockdown and having to work and teach online from home, academics reported poor quality sleep and short sleep duration. Further, on average, the sample reported working extensive hours and unhealthy lifestyle behaviours. The sleep health, nature of work and overall lifestyles of academic staff deserves more research attention, given the importance of their work and the impact that inadequate sleep could have on academics’ health and work performance. Sleep quality was worse for females and mid-career academics, suggesting that their sleep quality may be at greater risk than other sub-groups. However, the reasons for these differences need to be explored in future studies. The findings contribute to the narrative that academe involves numerous demands and supports previous research that has suggested that academics’ sleep is insufficient. Furthermore, COVID-19 had an impact on staff’s sleep, with staff reporting changes in their sleep quality and duration. The pandemic impacted work of academics by presenting novel demands related to online teaching, intensifying demands overall and disrupting work routines. However, future research is needed to understand academics’ sleep behaviours, work and lifestyles, especially in South Africa. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Le Grange, Sarah-Ann
- Date: 2022-04-06
- Subjects: Sleep-wake cycle South Africa Eastern Cape , Sleep Physiological aspects , Lifestyles Health aspects South Africa Eastern Cape , COVID-19 Pandemic, 2020- Influence , Work environment Psychological aspects , Work environment Physiological aspects , College teachers Workload South Africa Eastern Cape , Pittsburgh Sleep Quality Index (PSQI)
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291099 , vital:56818
- Description: Working in academe is characterized by high work demands, long and late working hours and balancing multiple roles. This often leaves academic staff (interchangeably referred to as ‘academics’ and ‘staff’) with limited time to prioritize adequate rest and sleep. While sufficient sleep is important for general well-being and work performance, it may be important for academics given the cognitive and interactive nature of their work. However, limited research has characterized sleep behaviours and sleep quality in academic staff globally and specifically in South Africa (SA). Further, research shows that academics from different academic ranks and genders differ in their work experiences but less is known about whether these factors affect their sleep and lifestyle factors. Over and above the demands of academic work, the current study was conducted during COVID-19, which saw unprecedented change in workloads for academic staff due to online teaching and learning. Additionally, the pandemic has been associated with poorer sleep quality and lifestyle behaviours in the general population, but very few studies have explored this in the context of academics. Thus, this study aimed to characterize the sleep quality, work and lifestyle factors among academics from a university in the Eastern Cape province of SA and determine the effects of gender and academic rank on these measures. Additionally, the study aimed to determine the impact of COVID-19 on sleep and work-related factors of this group. This study adopted a cross-sectional design and made use of an online questionnaire that was distributed to all academics employed at the institution via email. The data collection occurred over an 8-week testing period between August and September of 2020. The questionnaire explored sociodemographic, work and lifestyle characteristics, while the characteristics of sleep and sleep quality were explored with the Pittsburgh Sleep Quality Index (PSQI). Additionally, an open-ended section was included to determine the impact of COVID-19-related changes on sleep and work. The questionnaire responses were analyzed with descriptive and inferential statistics and the open-ended questions were analyzed with thematic analyses. A total of 84 respondents completed the questionnaire. On average, sleep quality was poor (global score of 7.09 ± 3.8), the reported sleep duration was short (6.41 ± 1.06 hrs) and the group was classified as overweight according to median BMI (26.67 [23.8-2 29.45] kg/m2). Over a third (35.71%) of academic staff reported not meeting physical activity guidelines and reported using screens one hour prior to bed every night during the week (76.19%) and the weekend (67.88%). Staff also worked long total weekly work hours (54.25 ± 11). Female academics had a poorer sleep quality (p = 0.035), spent a longer time in bed (p = 0.04), experienced more bad dreams (p = <0.01), had their last serving of alcohol earlier (p = 0.04) and worked less weekday (p = 0.04) and less total weekly (p = 0.02) hours compared to male academics. Professorship-level academics were significantly older than junior- and senior-level academics (p = <0.01) while senior-level academics had a poorer PSQI compared to professorship-level academics (p = 0.03). The thematic analysis showed that home environment, neighbourhood noise, work and mental health were the main emerging factors that disturbed sleep. The thematic analysis showed that, in relation to the impact of COVID19, sleep schedules changed and sleep duration and sleep quality improved or got worse. Respondents reported their work hours increasing, work schedules becoming less routine while working from home, dealing with the challenges of working online and experiencing worry, stress and anxiety due to the pandemic. The study highlights that, in the context of lockdown and having to work and teach online from home, academics reported poor quality sleep and short sleep duration. Further, on average, the sample reported working extensive hours and unhealthy lifestyle behaviours. The sleep health, nature of work and overall lifestyles of academic staff deserves more research attention, given the importance of their work and the impact that inadequate sleep could have on academics’ health and work performance. Sleep quality was worse for females and mid-career academics, suggesting that their sleep quality may be at greater risk than other sub-groups. However, the reasons for these differences need to be explored in future studies. The findings contribute to the narrative that academe involves numerous demands and supports previous research that has suggested that academics’ sleep is insufficient. Furthermore, COVID-19 had an impact on staff’s sleep, with staff reporting changes in their sleep quality and duration. The pandemic impacted work of academics by presenting novel demands related to online teaching, intensifying demands overall and disrupting work routines. However, future research is needed to understand academics’ sleep behaviours, work and lifestyles, especially in South Africa. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
- Full Text:
- Date Issued: 2022-04-06
An investigation into stakeholder inclusivity and the board’s ability to create competitive advantage at South Africa’s “big five” retail banks
- Authors: Wolhuter, Darren Wilfred
- Date: 2022-04-06
- Subjects: Stakeholder management South Africa , Strategic planning South Africa , Banks and banking South Africa , Corporate governance South Africa , Competition , Resource-based theory
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284548 , vital:56073
- Description: Stakeholder theory has long put forth the concept that managerial attention must be given to all stakeholders towards the realisation of value creation opportunities. Through the process of stakeholder engagement, and through the adoption of stakeholder inclusivity principles, an organisation can position itself to reap the benefits of understanding the legitimate needs and interests of all its stakeholders by seeking to satisfy all its stakeholders in turn. This study analysed the integrated reports of five retail banks, whose main base of operations were in South Africa, to assess the board’s ability to create value for its stakeholders through adopting a stakeholder inclusive approach to corporate governance as advocated for by the King Code on Corporate Governance in South Africa – King IV™. This assessment was done through an examination of a selection of outcomes relevant to the banking industry and related to each of the six capitals that form part of the value creation process as indicated for in the Integrated Reporting Framework (IIRC, 2013): 1) Financial Capital, 2) Manufactured Capital; 3) Intellectual Capital; 4) Human Capital; 5) Social and Relationship Capital, and; 6) Natural Capital. The results obtained, over a three-year period – 2018 to 2020, revealed that while the directors had a firm understanding of who their material stakeholders were, they struggled to create value that catered to all their stakeholders collectively. In addition, the directors were also unable to create sustainable value over the assessment period. As a result of this, most banks, with the exception of one, were unable to realise the value creation opportunities that could have led to a potential source of competitive advantage. The study concludes that while no observable sustainable competitive advantage was evident over the period of assessment, the concept of stakeholder inclusivity is an important corporate governance principle that drives value creation and, as such, warrants more attention from the director’s point of view. This research is intended to contribute to the growing knowledge on the importance of stakeholder inclusivity in corporate governance execution. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Wolhuter, Darren Wilfred
- Date: 2022-04-06
- Subjects: Stakeholder management South Africa , Strategic planning South Africa , Banks and banking South Africa , Corporate governance South Africa , Competition , Resource-based theory
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284548 , vital:56073
- Description: Stakeholder theory has long put forth the concept that managerial attention must be given to all stakeholders towards the realisation of value creation opportunities. Through the process of stakeholder engagement, and through the adoption of stakeholder inclusivity principles, an organisation can position itself to reap the benefits of understanding the legitimate needs and interests of all its stakeholders by seeking to satisfy all its stakeholders in turn. This study analysed the integrated reports of five retail banks, whose main base of operations were in South Africa, to assess the board’s ability to create value for its stakeholders through adopting a stakeholder inclusive approach to corporate governance as advocated for by the King Code on Corporate Governance in South Africa – King IV™. This assessment was done through an examination of a selection of outcomes relevant to the banking industry and related to each of the six capitals that form part of the value creation process as indicated for in the Integrated Reporting Framework (IIRC, 2013): 1) Financial Capital, 2) Manufactured Capital; 3) Intellectual Capital; 4) Human Capital; 5) Social and Relationship Capital, and; 6) Natural Capital. The results obtained, over a three-year period – 2018 to 2020, revealed that while the directors had a firm understanding of who their material stakeholders were, they struggled to create value that catered to all their stakeholders collectively. In addition, the directors were also unable to create sustainable value over the assessment period. As a result of this, most banks, with the exception of one, were unable to realise the value creation opportunities that could have led to a potential source of competitive advantage. The study concludes that while no observable sustainable competitive advantage was evident over the period of assessment, the concept of stakeholder inclusivity is an important corporate governance principle that drives value creation and, as such, warrants more attention from the director’s point of view. This research is intended to contribute to the growing knowledge on the importance of stakeholder inclusivity in corporate governance execution. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2022
- Full Text:
- Date Issued: 2022-04-06
An investigation into the force-EMG relationship for static and dynamic exertions
- Koekemoer, Wesley Agosthinho
- Authors: Koekemoer, Wesley Agosthinho
- Date: 2022-04-06
- Subjects: Electromyography , Force and energy , Muscles Physiology , Biomechanics , Muscle contraction , Isometric exercise , Isotonic exercise , Static and dynamic exertions
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291076 , vital:56816
- Description: The force-EMG relationship has multiple applications in varying fields of study and practice. One such application is the development of safety guidelines and regulations. Current guidelines are based on static muscle actions even though the majority of tasks encountered in industry are dynamic in nature. This may have negative implications for the health, safety, and productivity of workers as regulations based on static muscle actions may place higher force demands on manual labourers compared to what would be expected if regulations were based on dynamic muscle actions. Regulations based on dynamic muscle actions may be more effective in worker safety as the nature of the regulation matches that of the demand. Few studies have investigated the force-EMG relationship during dynamic muscle actions and the few that do exist have reported contradictory / mixed results. Therefore, the purpose of this study was to: 1) gain an understanding of EMG responses at different load levels, and 2) show how the relationship differs between static and dynamic muscle actions. A two-factorial repeated-measures experiment was developed for this study. Eighteen experimental conditions, utilizing six load levels (0%, 20%, 40%, 60%, 80%, and 100% of maximum voluntary force) for each of the three muscle actions (isometric, concentric and eccentric). Surface EMG responses were obtained under these conditions by repeatedly dorsiflexing and plantarflexing the foot, thus activating the soleus muscle. A maximum voluntary exertion on an isokinetic dynamometer determined the maximum force level, based on which the sub-maximal loads were calculated and added to a pulley system. 31 student participants were recruited for this experiment which was conducted over two sessions – one information and habituation session, and one experimental session. The EMG data recorded were processed and checked for normality and outliers. The data was then analysed via a General Linear Model analysis to determine the effect of exertion type and of load level on the muscle activity. Significant differences were identified at p<0.05 and followed by a Tukey post-hoc test. Correlation analyses were also conducted to determine the relationship between the force and EMG at all three exertion types. All dependent measures showed that as the load level increased so did the sEMG amplitude for all muscle actions. Muscle actions differed significantly between majority of six force levels. Correlations between the load levels and sEMG amplitude for each muscle action indicated a significant correlation with a moderate strength. The conclusion draws from this study that there is a positive correlation between force and sEMG amplitude, at all load levels, with a moderate strength. However, the muscle actions differed significantly from each other. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Koekemoer, Wesley Agosthinho
- Date: 2022-04-06
- Subjects: Electromyography , Force and energy , Muscles Physiology , Biomechanics , Muscle contraction , Isometric exercise , Isotonic exercise , Static and dynamic exertions
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291076 , vital:56816
- Description: The force-EMG relationship has multiple applications in varying fields of study and practice. One such application is the development of safety guidelines and regulations. Current guidelines are based on static muscle actions even though the majority of tasks encountered in industry are dynamic in nature. This may have negative implications for the health, safety, and productivity of workers as regulations based on static muscle actions may place higher force demands on manual labourers compared to what would be expected if regulations were based on dynamic muscle actions. Regulations based on dynamic muscle actions may be more effective in worker safety as the nature of the regulation matches that of the demand. Few studies have investigated the force-EMG relationship during dynamic muscle actions and the few that do exist have reported contradictory / mixed results. Therefore, the purpose of this study was to: 1) gain an understanding of EMG responses at different load levels, and 2) show how the relationship differs between static and dynamic muscle actions. A two-factorial repeated-measures experiment was developed for this study. Eighteen experimental conditions, utilizing six load levels (0%, 20%, 40%, 60%, 80%, and 100% of maximum voluntary force) for each of the three muscle actions (isometric, concentric and eccentric). Surface EMG responses were obtained under these conditions by repeatedly dorsiflexing and plantarflexing the foot, thus activating the soleus muscle. A maximum voluntary exertion on an isokinetic dynamometer determined the maximum force level, based on which the sub-maximal loads were calculated and added to a pulley system. 31 student participants were recruited for this experiment which was conducted over two sessions – one information and habituation session, and one experimental session. The EMG data recorded were processed and checked for normality and outliers. The data was then analysed via a General Linear Model analysis to determine the effect of exertion type and of load level on the muscle activity. Significant differences were identified at p<0.05 and followed by a Tukey post-hoc test. Correlation analyses were also conducted to determine the relationship between the force and EMG at all three exertion types. All dependent measures showed that as the load level increased so did the sEMG amplitude for all muscle actions. Muscle actions differed significantly between majority of six force levels. Correlations between the load levels and sEMG amplitude for each muscle action indicated a significant correlation with a moderate strength. The conclusion draws from this study that there is a positive correlation between force and sEMG amplitude, at all load levels, with a moderate strength. However, the muscle actions differed significantly from each other. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
- Full Text:
- Date Issued: 2022-04-06
Antimalarial activity of quinoline thiosemicarbazones: synthesis and antiplasmodial evaluation
- Nqeno, Lukhanyiso Khanyisile
- Authors: Nqeno, Lukhanyiso Khanyisile
- Date: 2022-04-06
- Subjects: Antimalarials , Quinoline , Thiosemicarbazones , Malaria Chemotherapy , Plasmodium falciparum , Malaria Africa, Sub-Saharan , Iron chelates Therapeutic use
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291292 , vital:56841
- Description: Africa is one of the regions that is most affected by malaria, as 90% of all malaria deaths occur in sub-saharan Africa. Malaria is a life threatening disease responsible for an estimated 800000 deaths each year, the majority of these deaths occurred in children under the age of five. The disease is a mosquito-borne, and it is transmitted to humans by the female Anopheles mosquito. The parasite responsible for this disease belong to the Plasmodium genus with Plasmodium falciparum causing the most severe cases of the disease in humans. The most widely available anti-malarials were designed to specifically target the pathogenic blood stage in humans, however, in order to completely eradicate malaria there is a need for the development of medicines that not only target the pathogenic blood stage of the parasite but also block parasite transmission and eliminate asymptomatic and cryptic hepatic forms of the parasite. Iron chelators have recently gained importance as potent antimalarials, to cause infection nearly all protozoa obtain growth essential iron from their hosts. Iron is required for the development of the parasite. Deprivation of utilizable iron by chelation is a proficient approach to arrest parasite growth and associated infection. Thiosemicarbazones are known iron chelating agents by bonding through the sulfur and azomethine nitrogen atoms. This study is aimed at the identification of thiosemicarbazone based derivatives as possible antimalarial agents. Due to their iron chelation abilities there has been increasing interest in the investigation of thiosemicarbazones as possible antimalarials. During the course of this project, several thiosemicarbazone derivatives were synthesized and their structure confirmed using routine analytical techniques (NMR, FTIR, and HRMS). The synthesized compounds were evaluated in vitro against the chloroquine sensitive strain (3D7) of P. falciparum for antimarial activity. The compounds were also evaluated agsinst Hela cells for overt cytotoxicity. The compounds generally showed poor antimalarial activity. One compound (LKN11) was identified to possess intrinsic and moderate antimalarial activity of 6.6 μM. The compounds were generally not cytotoxic against Hela cell at concentrations of up to 20 μM, with only compound LKN10 showing modest cytotoxic activity of 9.5 μM. This research went on to identify two thiosemicarbazone based derivatives which had a significant effect on HeLa and pLDH cells. , Thesis (MSc) -- Faculty of Science, Chemistry, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Nqeno, Lukhanyiso Khanyisile
- Date: 2022-04-06
- Subjects: Antimalarials , Quinoline , Thiosemicarbazones , Malaria Chemotherapy , Plasmodium falciparum , Malaria Africa, Sub-Saharan , Iron chelates Therapeutic use
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/291292 , vital:56841
- Description: Africa is one of the regions that is most affected by malaria, as 90% of all malaria deaths occur in sub-saharan Africa. Malaria is a life threatening disease responsible for an estimated 800000 deaths each year, the majority of these deaths occurred in children under the age of five. The disease is a mosquito-borne, and it is transmitted to humans by the female Anopheles mosquito. The parasite responsible for this disease belong to the Plasmodium genus with Plasmodium falciparum causing the most severe cases of the disease in humans. The most widely available anti-malarials were designed to specifically target the pathogenic blood stage in humans, however, in order to completely eradicate malaria there is a need for the development of medicines that not only target the pathogenic blood stage of the parasite but also block parasite transmission and eliminate asymptomatic and cryptic hepatic forms of the parasite. Iron chelators have recently gained importance as potent antimalarials, to cause infection nearly all protozoa obtain growth essential iron from their hosts. Iron is required for the development of the parasite. Deprivation of utilizable iron by chelation is a proficient approach to arrest parasite growth and associated infection. Thiosemicarbazones are known iron chelating agents by bonding through the sulfur and azomethine nitrogen atoms. This study is aimed at the identification of thiosemicarbazone based derivatives as possible antimalarial agents. Due to their iron chelation abilities there has been increasing interest in the investigation of thiosemicarbazones as possible antimalarials. During the course of this project, several thiosemicarbazone derivatives were synthesized and their structure confirmed using routine analytical techniques (NMR, FTIR, and HRMS). The synthesized compounds were evaluated in vitro against the chloroquine sensitive strain (3D7) of P. falciparum for antimarial activity. The compounds were also evaluated agsinst Hela cells for overt cytotoxicity. The compounds generally showed poor antimalarial activity. One compound (LKN11) was identified to possess intrinsic and moderate antimalarial activity of 6.6 μM. The compounds were generally not cytotoxic against Hela cell at concentrations of up to 20 μM, with only compound LKN10 showing modest cytotoxic activity of 9.5 μM. This research went on to identify two thiosemicarbazone based derivatives which had a significant effect on HeLa and pLDH cells. , Thesis (MSc) -- Faculty of Science, Chemistry, 2022
- Full Text:
- Date Issued: 2022-04-06