Colonisation and succession of fishes in Lake Liambezi, a shallow ephemeral floodplain lake in Southern Africa
- Authors: Peel, Richard Anthony
- Date: 2017
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/65211 , vital:28707
- Description: Expected release date-May 2019
- Full Text:
- Authors: Peel, Richard Anthony
- Date: 2017
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/65211 , vital:28707
- Description: Expected release date-May 2019
- Full Text:
Combined in silico approaches towards the identification of novel malarial cysteine protease inhibitors
- Authors: Musyoka, Thommas Mutemi
- Date: 2017
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/4488 , vital:20679
- Description: Malaria an infectious disease caused by a group of parasitic organisms of the Plasmodium genus remains a severe public health problem in Africa, South America and parts of Asia. The leading causes for the persistence of malaria are the emergence of drug resistance to common antimalarial drugs, lack of effective vaccines and the inadequate control of mosquito vectors. Worryingly, accumulating evidence shows that the parasite has developed resistant to the current first-line treatment based on artemisinin. Hence, the identification and characterization of novel drug targets and drugs with unique mode of action remains an urgent priority. The successful sequencing and assembly of genomes from several Plasmodium species has opened an opportune window for the identification of new drug targets. Cysteine proteases are one of the major drug targets to be identified so far. The use of cysteine protease inhibitors coupled with gene manipulation studies has defined specific and putative roles of cysteine proteases which include hemoglobin degradation, erythrocyte rupture, immune evasion and erythrocyte invasion, steps which are central for the completion of the Plasmodium parasite life cycle. In an aim to discover potential novel antimalarials, this thesis focussed on falcipains (FPs), a group of four papain-like cysteine proteases from Plasmodium falciparum. Two of these enzymes, FP-2 and FP-3 are the major hemoglobinases and have been validated as drug targets. For the successful elimination of malaria, drugs must be safe and target both human and wild Plasmodium infective forms. Thus, an incipient aim was to identify protein homologs of these two proteases from other Plasmodium species and the host (human). From BLASTP analysis, up to 16 FP-2 and FP-3 homologs were identified (13 plasmodial proteases and 3 human cathepsins). Using in silico characterization approaches, the intra and inter group sequence, structural, phylogenetic and physicochemical differences were determined. To extend previous work (MSc student) involving docking studies on the identified proteins using known FP-2 and FP-3 inhibitors, a South African natural compound and its ZINC analogs, molecular dynamics and binding free energy studies were performed to determine the stabilities and quantification of the strength of interactions between the different protein-ligand complexes. From the results, key structural elements that regulate the binding and selectivity of non-peptidic compounds onto the different proteins were deciphered. Interaction fingerprints and energy decomposition analysis identified key residues and energetic terms that are central for effective ligand binding. This research presents novel insight essential for the structure-based molecular drug design of more potent antimalarial drugs.
- Full Text:
- Authors: Musyoka, Thommas Mutemi
- Date: 2017
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/4488 , vital:20679
- Description: Malaria an infectious disease caused by a group of parasitic organisms of the Plasmodium genus remains a severe public health problem in Africa, South America and parts of Asia. The leading causes for the persistence of malaria are the emergence of drug resistance to common antimalarial drugs, lack of effective vaccines and the inadequate control of mosquito vectors. Worryingly, accumulating evidence shows that the parasite has developed resistant to the current first-line treatment based on artemisinin. Hence, the identification and characterization of novel drug targets and drugs with unique mode of action remains an urgent priority. The successful sequencing and assembly of genomes from several Plasmodium species has opened an opportune window for the identification of new drug targets. Cysteine proteases are one of the major drug targets to be identified so far. The use of cysteine protease inhibitors coupled with gene manipulation studies has defined specific and putative roles of cysteine proteases which include hemoglobin degradation, erythrocyte rupture, immune evasion and erythrocyte invasion, steps which are central for the completion of the Plasmodium parasite life cycle. In an aim to discover potential novel antimalarials, this thesis focussed on falcipains (FPs), a group of four papain-like cysteine proteases from Plasmodium falciparum. Two of these enzymes, FP-2 and FP-3 are the major hemoglobinases and have been validated as drug targets. For the successful elimination of malaria, drugs must be safe and target both human and wild Plasmodium infective forms. Thus, an incipient aim was to identify protein homologs of these two proteases from other Plasmodium species and the host (human). From BLASTP analysis, up to 16 FP-2 and FP-3 homologs were identified (13 plasmodial proteases and 3 human cathepsins). Using in silico characterization approaches, the intra and inter group sequence, structural, phylogenetic and physicochemical differences were determined. To extend previous work (MSc student) involving docking studies on the identified proteins using known FP-2 and FP-3 inhibitors, a South African natural compound and its ZINC analogs, molecular dynamics and binding free energy studies were performed to determine the stabilities and quantification of the strength of interactions between the different protein-ligand complexes. From the results, key structural elements that regulate the binding and selectivity of non-peptidic compounds onto the different proteins were deciphered. Interaction fingerprints and energy decomposition analysis identified key residues and energetic terms that are central for effective ligand binding. This research presents novel insight essential for the structure-based molecular drug design of more potent antimalarial drugs.
- Full Text:
Communication in selected Eastern Cape public healthcare facilities offering termination of pregnancy services: inter/intra-cultural implications
- Authors: Mavuso, Snethemba Fikile
- Date: 2017
- Subjects: Communication in medicine -- South Africa , Medical care -- Communication systems -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/7290 , vital:21239
- Description: This study examines pre-termination of pregnancy (PTOP) counselling, focussing on issues of language and access, and sociocultural influences. This research examines linguistic and cultural aspects of communication between healthcare providers and clients in PTOP contexts. The overarching aim of this research was to identify patterns that indicate miscommunication and to propose ways to bridge any linguistic and cultural gaps. This research examine how social norms related to turn taking guide healthcare providers - clients interaction and how the clients respond to advice offered during the counselling sessions. The study provides an indepth understanding of linguistic and cultural barriers in public healthcare, and further emphasizes the need for implementation of support systems for cross-cultural and effective patient-centred communication in healthcare. The findings in this study are thatpresent that miscommunication occurs within intercultural and intra-cultural medical encounters. Excessive use of medical terminology causes communication difficulties. Clients often provide a positive response to indicate that they understand what the healthcare provider is communicating. Clients sometimes respond positively out of politeness. This practice is common in some cultures; it often occurs when the recipient is interacting with a figure of authority or someone of higher positioning. It is found that healthcare provider’s value systems sometimes have an impact on their professional conduct, influencing the type of PTOP counselling provided to clients. Sometimes the language and communication barriers have a negative impact on the quality of care/PTOP counselling. This study argues that healthcare provider’s communication styles and value systems influence PTOP counselling. Healthcare providers have the power to control the medical discourse; their turns at talk influence those of clients. The manner in which the nurses and counsellors address the clients elicits a certain response. This study thus suggests that healthcare providers need to improve their communicative skills, be mindful of their position as power holders and adopt a patient-centred approach, which is crucial for clinical and cultural competence.
- Full Text:
- Authors: Mavuso, Snethemba Fikile
- Date: 2017
- Subjects: Communication in medicine -- South Africa , Medical care -- Communication systems -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/7290 , vital:21239
- Description: This study examines pre-termination of pregnancy (PTOP) counselling, focussing on issues of language and access, and sociocultural influences. This research examines linguistic and cultural aspects of communication between healthcare providers and clients in PTOP contexts. The overarching aim of this research was to identify patterns that indicate miscommunication and to propose ways to bridge any linguistic and cultural gaps. This research examine how social norms related to turn taking guide healthcare providers - clients interaction and how the clients respond to advice offered during the counselling sessions. The study provides an indepth understanding of linguistic and cultural barriers in public healthcare, and further emphasizes the need for implementation of support systems for cross-cultural and effective patient-centred communication in healthcare. The findings in this study are thatpresent that miscommunication occurs within intercultural and intra-cultural medical encounters. Excessive use of medical terminology causes communication difficulties. Clients often provide a positive response to indicate that they understand what the healthcare provider is communicating. Clients sometimes respond positively out of politeness. This practice is common in some cultures; it often occurs when the recipient is interacting with a figure of authority or someone of higher positioning. It is found that healthcare provider’s value systems sometimes have an impact on their professional conduct, influencing the type of PTOP counselling provided to clients. Sometimes the language and communication barriers have a negative impact on the quality of care/PTOP counselling. This study argues that healthcare provider’s communication styles and value systems influence PTOP counselling. Healthcare providers have the power to control the medical discourse; their turns at talk influence those of clients. The manner in which the nurses and counsellors address the clients elicits a certain response. This study thus suggests that healthcare providers need to improve their communicative skills, be mindful of their position as power holders and adopt a patient-centred approach, which is crucial for clinical and cultural competence.
- Full Text:
Comparative localization studies of P.falciparum ADP-ribosylation factor proteins in P.falciparum parasites and hela cells using GFP tagged constructs
- Authors: Swart, Tarryn
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/3537 , vital:20519
- Description: Expected release date-December 2018
- Full Text:
- Authors: Swart, Tarryn
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/3537 , vital:20519
- Description: Expected release date-December 2018
- Full Text:
Composition portfolio
- Boesack, Lenrick Jonathan Angus
- Authors: Boesack, Lenrick Jonathan Angus
- Date: 2017
- Subjects: Piano music , Prepared piano music , Saxophone music
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/56233 , vital:26786
- Description: This short composition portfolio comprises 40% of the requirements for the Master of Music Degree in performance and composition at Rhodes University. In addition to the music presented here, I played two public exam recitals of 70 minutes each. While I played piano as a child, my main instrument during my BMUS studies at the University of Cape Town (2004-2007) was the saxophone. In 2010 I was diagnosed with Polymyositis(an auto-immune desease) which particularly affected my breathing and therefore my ability to play the saxophone. For this reason I opted to play my recitals on the piano. The first recital focused on interpretations of Swing Era, Bebop and post-Bebop standards such as: Someday my prince will come, What is this thing called love, In your own sweet way, Eternal Triangle, Recordame, Peace, Dolphin Dance, Caravan and Some other blues. The second recital comprised of seven original compositions that were presented in trio, quartet and quintet settings.
- Full Text:
- Authors: Boesack, Lenrick Jonathan Angus
- Date: 2017
- Subjects: Piano music , Prepared piano music , Saxophone music
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/56233 , vital:26786
- Description: This short composition portfolio comprises 40% of the requirements for the Master of Music Degree in performance and composition at Rhodes University. In addition to the music presented here, I played two public exam recitals of 70 minutes each. While I played piano as a child, my main instrument during my BMUS studies at the University of Cape Town (2004-2007) was the saxophone. In 2010 I was diagnosed with Polymyositis(an auto-immune desease) which particularly affected my breathing and therefore my ability to play the saxophone. For this reason I opted to play my recitals on the piano. The first recital focused on interpretations of Swing Era, Bebop and post-Bebop standards such as: Someday my prince will come, What is this thing called love, In your own sweet way, Eternal Triangle, Recordame, Peace, Dolphin Dance, Caravan and Some other blues. The second recital comprised of seven original compositions that were presented in trio, quartet and quintet settings.
- Full Text:
Composition portfolio
- Authors: Caplan, Anthony
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/6940 , vital:21202
- Description: Restricted access-thesis available at the Music Library
- Full Text: false
- Authors: Caplan, Anthony
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/6940 , vital:21202
- Description: Restricted access-thesis available at the Music Library
- Full Text: false
Contemporary Zambian art, conceptualism and the ‘global’ art world
- Authors: Mulenga, Andrew Mukuka
- Date: 2017
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: http://hdl.handle.net/10962/5187 , vital:20784
- Description: In Zambia, ‘contemporary art’ (as a category constructed by the European-dominated international art world), was introduced by the European settler community and continued within its preserve, remaining largely inaccessible to the indigenous community of Africans until Zambia’s independence in 1964. This thesis traces the integration of Africans into the contemporary art community and attributes the process, in part, to a small group of artists of European descent who played a significant role in engaging with Zambians, working side by side with them, subsequently influencing their art production and implicitly shaping the ways in which ‘Zambian’ art ‘ought to’ look for decades to come. The research traces the early days of contemporary art practice in Zambia to the Lusaka Art Society and Art Centre Foundation that was founded and run by an all-settler group of formally trained artists with a particular inclination towards sculpture and painting. In the wake of the integration however, art production in the formalist manner was further proliferated by the European diplomatic community which would also go as far as dictating artistic subject matter. This thesis argues that the Eurocentric and pre-eminently formalist approach to contemporary art has cost Zambian artists an international presence. I submit that the few instances where contemporary Zambian art practice has penetrated the ‘global art’ scene or caught the attention of international curators is due to artists adopting more radical conceptual approaches to art production, often creating tensions with local viewers. This thesis also examines conceptualism in contemporary Zambian art practice and examines the inequalities of the ‘global art’ world. I argue that conceptual art, although not generally accepted on the Zambian art scene, has played a vital role in helping Zambian artists enter the global art world, albeit modestly.
- Full Text:
- Authors: Mulenga, Andrew Mukuka
- Date: 2017
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: http://hdl.handle.net/10962/5187 , vital:20784
- Description: In Zambia, ‘contemporary art’ (as a category constructed by the European-dominated international art world), was introduced by the European settler community and continued within its preserve, remaining largely inaccessible to the indigenous community of Africans until Zambia’s independence in 1964. This thesis traces the integration of Africans into the contemporary art community and attributes the process, in part, to a small group of artists of European descent who played a significant role in engaging with Zambians, working side by side with them, subsequently influencing their art production and implicitly shaping the ways in which ‘Zambian’ art ‘ought to’ look for decades to come. The research traces the early days of contemporary art practice in Zambia to the Lusaka Art Society and Art Centre Foundation that was founded and run by an all-settler group of formally trained artists with a particular inclination towards sculpture and painting. In the wake of the integration however, art production in the formalist manner was further proliferated by the European diplomatic community which would also go as far as dictating artistic subject matter. This thesis argues that the Eurocentric and pre-eminently formalist approach to contemporary art has cost Zambian artists an international presence. I submit that the few instances where contemporary Zambian art practice has penetrated the ‘global art’ scene or caught the attention of international curators is due to artists adopting more radical conceptual approaches to art production, often creating tensions with local viewers. This thesis also examines conceptualism in contemporary Zambian art practice and examines the inequalities of the ‘global art’ world. I argue that conceptual art, although not generally accepted on the Zambian art scene, has played a vital role in helping Zambian artists enter the global art world, albeit modestly.
- Full Text:
Conversations between trip hop and jazz
- Authors: Lang, Jared Anthony
- Date: 2017
- Subjects: Trip hop (Music) , Jazz
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/5009 , vital:20752
- Description: Restricted access-thesis available at the Music Library
- Full Text: false
- Authors: Lang, Jared Anthony
- Date: 2017
- Subjects: Trip hop (Music) , Jazz
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/5009 , vital:20752
- Description: Restricted access-thesis available at the Music Library
- Full Text: false
Conversations, turn-taking, and dialogue: an analysis of the political deliberations of Zimbabwean citizens on the @263Chat Twitter handle
- Authors: Ncube, Meli Mthabisi
- Date: 2017
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/4510 , vital:20684
- Description: The micro-blogging site Twitter, and the social networking site Facebook, are playing a key role in facilitating active political expression in the form of demonstrations against high rates of unemployment, poverty, rampant government repression and corruption. Twitter use in Zimbabwe is very vibrant and it even has its own name, ‘Zwitter.’ Zimbabwe has a closed legacy news media which are highly restricted, and most of the major news outlets are controlled by the state. Another limiting factor to any meaningful practice of deliberative democracy through the media and town hall debates is the intolerance of the ruling party ZANU-PF in dealing with dissenting voices. Thus in Zimbabwean politics, it can be argued that the internet has liberated political debates that have been suppressed and digital media is central to political and social deliberation. This study examines whether there are conversations, turn-taking, and dialogues-all features of deliberations- on the @263Chat Twitter platform which is used as a case study. Qualitative content analysis and interviewing were used to collect the data. The preliminary results of the research show that citizen-led engagements, which are facilitated by @263Chat, have brought to the fore the covert potential of social media platforms to drive political participation and deliberation.
- Full Text:
- Authors: Ncube, Meli Mthabisi
- Date: 2017
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/4510 , vital:20684
- Description: The micro-blogging site Twitter, and the social networking site Facebook, are playing a key role in facilitating active political expression in the form of demonstrations against high rates of unemployment, poverty, rampant government repression and corruption. Twitter use in Zimbabwe is very vibrant and it even has its own name, ‘Zwitter.’ Zimbabwe has a closed legacy news media which are highly restricted, and most of the major news outlets are controlled by the state. Another limiting factor to any meaningful practice of deliberative democracy through the media and town hall debates is the intolerance of the ruling party ZANU-PF in dealing with dissenting voices. Thus in Zimbabwean politics, it can be argued that the internet has liberated political debates that have been suppressed and digital media is central to political and social deliberation. This study examines whether there are conversations, turn-taking, and dialogues-all features of deliberations- on the @263Chat Twitter platform which is used as a case study. Qualitative content analysis and interviewing were used to collect the data. The preliminary results of the research show that citizen-led engagements, which are facilitated by @263Chat, have brought to the fore the covert potential of social media platforms to drive political participation and deliberation.
- Full Text:
Credit extension in South Africa: an analysis of the impact of interest rates and income levels on the level of household debt
- Widdop, James Stuart Hailstones
- Authors: Widdop, James Stuart Hailstones
- Date: 2017
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10962/4988 , vital:20750
- Description: The recent growth in the unsecured lending market and the bankruptcy of African Bank Investments Limited have brought to light concerns regarding credit extension and the level of household indebtedness in South Africa. This study seeks to investigate the relevant aspects of credit extension in both the secured and unsecured lending markets by firstly analysing contemporary literature and then conducting a more formal empirical analysis. A VAR model is estimated to examine the effects household disposable income and interest rates have on the level of household debt in South Africa for the period 1995Q1-2015Q3. The empirical results indicate that there is no significant deterministic relationship between household disposable income and household debt. However, the results show that such a relationship does exist between interest rate and household debt. Finally, impulse response functions obtained from the VAR estimation are examined which indicate that both shocks too household disposable income and interest rates effect the level of household debt, but that this effect returns to equilibrium within six periods.
- Full Text:
- Authors: Widdop, James Stuart Hailstones
- Date: 2017
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10962/4988 , vital:20750
- Description: The recent growth in the unsecured lending market and the bankruptcy of African Bank Investments Limited have brought to light concerns regarding credit extension and the level of household indebtedness in South Africa. This study seeks to investigate the relevant aspects of credit extension in both the secured and unsecured lending markets by firstly analysing contemporary literature and then conducting a more formal empirical analysis. A VAR model is estimated to examine the effects household disposable income and interest rates have on the level of household debt in South Africa for the period 1995Q1-2015Q3. The empirical results indicate that there is no significant deterministic relationship between household disposable income and household debt. However, the results show that such a relationship does exist between interest rate and household debt. Finally, impulse response functions obtained from the VAR estimation are examined which indicate that both shocks too household disposable income and interest rates effect the level of household debt, but that this effect returns to equilibrium within six periods.
- Full Text:
Crime and punishment Mzansi style: an exploration of the discursive production of criminality and popular justice in South Africa’s Daily Sun
- Authors: Boshoff, Priscilla
- Date: 2017
- Subjects: Daily Sun (South Africa) , Tabloid newpapers -- South Africa , Crime in mass media , Justice in mass media , Police in mass media , Newpapers -- South Africa , Newpapers -- Objectivity -- South Africa , Women -- Violence against -- South Africa -- Press coverage , Witchcraft -- South Africa -- Press coverage , Police -- South Africa -- Press coverage
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/44419 , vital:25406
- Description: The highly popular South African tabloid the Daily Sun, established post-apartheid in 2002, is known for its sensationalist and controversial reporting of black township life. Read by over five million black working class readers, much of its reporting concerns the crimes experienced by them and their struggles for justice. The extraordinarily high rate of violent crime in township areas for which South Africa became infamous during the 1980s did not decrease as much as hoped after the political transition in 1994 and crime overshadowed the first decades of the new administration, adding to the frustrations generated by the slow pace of social and economic reform. Part of the Daily Sun’s success can be attributed to how, around these linked concerns, it fashions for its readers a particular discursive world, Sunland. It is the phatic relationship that the tabloid maintains between itself and its readers which forms the foundation upon which this textual study rests. In approaching the tabloid’s representations of crime I draw on cultural criminological understandings of crime as culture and the formative relationship in this regard between crime and the media. As a preeminent site of cultural production in contemporary society, the media contribute to the ongoing definition of what constitutes crime, who is criminal and what counts as justice. This constructivist approach is congruent with Foucault’s notions of discourse and the subject, and I argue that the various competing discourses about crime and justice which appear in the paper establish a set of subjectivities with which its readers may identity. The thesis explores the rhetorical and discursive means by which such subject positions are constructed within the ‘grid of intelligibility’ created by the Daily Sun’s reportage, and using the spatial metaphor of the ‘map’ I trace the contours of the Daily Sun’s domain with regard to crime and popular justice. To this end, the approach taken is a qualitative one which draws eclectically on a variety of interpretive methods, including semiotic, narrative and discourse analysis. Using these, I map the relations between People’s Justice, the police, gender relations and witchcraft crimes, four areas chosen from a broad thematic content analysis of the complete set of editions from 2011. I show how these are not discreet but co-constructed areas within the coverage, drawing their meaning mutually from a range of conflictual relationships derived from the conditions of post-apartheid social life.
- Full Text:
- Authors: Boshoff, Priscilla
- Date: 2017
- Subjects: Daily Sun (South Africa) , Tabloid newpapers -- South Africa , Crime in mass media , Justice in mass media , Police in mass media , Newpapers -- South Africa , Newpapers -- Objectivity -- South Africa , Women -- Violence against -- South Africa -- Press coverage , Witchcraft -- South Africa -- Press coverage , Police -- South Africa -- Press coverage
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/44419 , vital:25406
- Description: The highly popular South African tabloid the Daily Sun, established post-apartheid in 2002, is known for its sensationalist and controversial reporting of black township life. Read by over five million black working class readers, much of its reporting concerns the crimes experienced by them and their struggles for justice. The extraordinarily high rate of violent crime in township areas for which South Africa became infamous during the 1980s did not decrease as much as hoped after the political transition in 1994 and crime overshadowed the first decades of the new administration, adding to the frustrations generated by the slow pace of social and economic reform. Part of the Daily Sun’s success can be attributed to how, around these linked concerns, it fashions for its readers a particular discursive world, Sunland. It is the phatic relationship that the tabloid maintains between itself and its readers which forms the foundation upon which this textual study rests. In approaching the tabloid’s representations of crime I draw on cultural criminological understandings of crime as culture and the formative relationship in this regard between crime and the media. As a preeminent site of cultural production in contemporary society, the media contribute to the ongoing definition of what constitutes crime, who is criminal and what counts as justice. This constructivist approach is congruent with Foucault’s notions of discourse and the subject, and I argue that the various competing discourses about crime and justice which appear in the paper establish a set of subjectivities with which its readers may identity. The thesis explores the rhetorical and discursive means by which such subject positions are constructed within the ‘grid of intelligibility’ created by the Daily Sun’s reportage, and using the spatial metaphor of the ‘map’ I trace the contours of the Daily Sun’s domain with regard to crime and popular justice. To this end, the approach taken is a qualitative one which draws eclectically on a variety of interpretive methods, including semiotic, narrative and discourse analysis. Using these, I map the relations between People’s Justice, the police, gender relations and witchcraft crimes, four areas chosen from a broad thematic content analysis of the complete set of editions from 2011. I show how these are not discreet but co-constructed areas within the coverage, drawing their meaning mutually from a range of conflictual relationships derived from the conditions of post-apartheid social life.
- Full Text:
Critical analysis of landscape and belonging in Mola, Nyaminyami District, Zimbabwe
- Authors: Tombindo, Felix
- Date: 2017
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: http://hdl.handle.net/10962/7533 , vital:21270
- Description: Land and inanimate resources constitute the most dominant theme in the history of Zimbabwe. Questions around land, the environment and natural resources in Zimbabwe have recently focused on the contentious Fast Track Land Reform Programme of the year 2000. Yet Zimbabwe’s land questions are not limited to this contentious land reform programme. Among Zimbabwe’s contentious land questions are those of the Tonga people, displaced in the 1950s to pave way for the construction of the Kariba dam. These people have faced further displacement through conservation-induced restrictions on land and environmental resource use, particularly in the Zambezi Valley and specifically in areas where they were relocated after the dam-induced displacement. This thesis examines the ways in which the Tonga people of Mola in NyamiNyami District have framed their present environment to place imprints in Mola from their Zambezi landscape and to convert Mola into a landscape of home and belonging. It looks at how the Tonga in Mola use these narratives of home and belonging to claim and contest access to environmental resources in the face of an unfettered regime of displacement and restricted environmental resource use. These narratives of home are located within the context of memories of the history of Kariba dam-induced displacement and present-day environmental conservation regime practices. The thesis frames the case study of the Tonga in Mola analytically through the use of mainly a social constructionist theory of landscape and, less so, with reference to the Bourdieusian concept of habitus. It uses qualitative research methods in doing so. The thesis reveals that, for the Tonga of Mola, the environment is a complex mix of physical space (natural environment) and non-physical entities that include ancestors. Because of this, the Mola Tongan environment is multifaceted and this entails landscape as lived reality and a sacred space. The ancestors, referred to locally as banalyo gundu (meaning ‘owners of the land’), constitute a key way in which the Tonga claim belonging to Mola, Lake Kariba and the Zambezi Valley escarpment. The thesis also identifies and highlights the phenomenon of a dual belonging (attachment to two places), namely Mola and the place from which they were displaced. This exists despite the many years since their displacement for the construction of Kariba. Based on their understandings of landscape, the Tonga of Mola construct notions of belonging and entitlement to Mola and Lake Kariba that exclude and include others at the local and national levels. Overall, belonging in Mola is presented and practised as a discursive, socially constructed phenomenon that exists at local and national levels.
- Full Text:
- Authors: Tombindo, Felix
- Date: 2017
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: http://hdl.handle.net/10962/7533 , vital:21270
- Description: Land and inanimate resources constitute the most dominant theme in the history of Zimbabwe. Questions around land, the environment and natural resources in Zimbabwe have recently focused on the contentious Fast Track Land Reform Programme of the year 2000. Yet Zimbabwe’s land questions are not limited to this contentious land reform programme. Among Zimbabwe’s contentious land questions are those of the Tonga people, displaced in the 1950s to pave way for the construction of the Kariba dam. These people have faced further displacement through conservation-induced restrictions on land and environmental resource use, particularly in the Zambezi Valley and specifically in areas where they were relocated after the dam-induced displacement. This thesis examines the ways in which the Tonga people of Mola in NyamiNyami District have framed their present environment to place imprints in Mola from their Zambezi landscape and to convert Mola into a landscape of home and belonging. It looks at how the Tonga in Mola use these narratives of home and belonging to claim and contest access to environmental resources in the face of an unfettered regime of displacement and restricted environmental resource use. These narratives of home are located within the context of memories of the history of Kariba dam-induced displacement and present-day environmental conservation regime practices. The thesis frames the case study of the Tonga in Mola analytically through the use of mainly a social constructionist theory of landscape and, less so, with reference to the Bourdieusian concept of habitus. It uses qualitative research methods in doing so. The thesis reveals that, for the Tonga of Mola, the environment is a complex mix of physical space (natural environment) and non-physical entities that include ancestors. Because of this, the Mola Tongan environment is multifaceted and this entails landscape as lived reality and a sacred space. The ancestors, referred to locally as banalyo gundu (meaning ‘owners of the land’), constitute a key way in which the Tonga claim belonging to Mola, Lake Kariba and the Zambezi Valley escarpment. The thesis also identifies and highlights the phenomenon of a dual belonging (attachment to two places), namely Mola and the place from which they were displaced. This exists despite the many years since their displacement for the construction of Kariba. Based on their understandings of landscape, the Tonga of Mola construct notions of belonging and entitlement to Mola and Lake Kariba that exclude and include others at the local and national levels. Overall, belonging in Mola is presented and practised as a discursive, socially constructed phenomenon that exists at local and national levels.
- Full Text:
Dance as a tool for emotional well-being
- Authors: Conchar, Lauren
- Date: 2017
- Subjects: Dance therapy , Well-being , Happiness , Adolescent psychology , Dance -- Social aspects -- South Africa -- Cape Flats , Dance -- Psychological aspects -- South Africa -- Cape Flats , Dance -- Psychological aspects -- South Africa -- Cape Flats -- Case studies , Community development, Urban -- Psychological aspects -- South Africa -- Cape Flats -- Case studies
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/5129 , vital:20779
- Description: Dance has numerous benefits for emotional well-being. For young people specifically it can serve as a prosocial activity where they can engage in a purposeful activity, in a safe space with consistent boundaries and discipline, while surrounded by peers, teachers and positive role models. Recreational spaces that allow young people to feel safe and express themselves is especially important in low socioeconomic areas where there are limited resources and exposure to heightened levels of crime as young people may be less likely to engage in negative behaviours when they have access to alternative, positive activities. This research aimed to explore the lived experiences of a group of young people who participate in dance classes at a community dance project in the Western Cape. The sample group consisted of four young people between the ages of 16 and 20. Semi-structured interviews were conducted with the participants and the interviews were analysed using interpretative phenomenological analysis. Three major themes emerged from the data, namely 1) My exposure to dance - The impact of context, 2) What motivates me to continue attending classes - The fulfilment of the three basic psychological needs, and 3) How does dance make me feel - The experience of emotional well-being through dance. The discussion of the findings yielded many similarities between the experiences of the participants and the relevant literature. Further, it appears that all four participants experience the satisfaction of the three basic psychological needs (competence, autonomy and relatedness) at the centre. This may serve as a motivator to continue attending classes as well as contribute to sustained eudaimonic wellbeing. Recommendations include further studies being conducted with groups of young people engaging in dance projects in different socioeconomic contexts and in different parts of South Africa. This could give us a more rounded understanding of how people young people experience dance class and how it contributes to emotional well-being. Further research could also be conducted with recreational projects that offer other activities in under-resourced areas in order to better inform the development of such recreational activities.
- Full Text:
- Authors: Conchar, Lauren
- Date: 2017
- Subjects: Dance therapy , Well-being , Happiness , Adolescent psychology , Dance -- Social aspects -- South Africa -- Cape Flats , Dance -- Psychological aspects -- South Africa -- Cape Flats , Dance -- Psychological aspects -- South Africa -- Cape Flats -- Case studies , Community development, Urban -- Psychological aspects -- South Africa -- Cape Flats -- Case studies
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/5129 , vital:20779
- Description: Dance has numerous benefits for emotional well-being. For young people specifically it can serve as a prosocial activity where they can engage in a purposeful activity, in a safe space with consistent boundaries and discipline, while surrounded by peers, teachers and positive role models. Recreational spaces that allow young people to feel safe and express themselves is especially important in low socioeconomic areas where there are limited resources and exposure to heightened levels of crime as young people may be less likely to engage in negative behaviours when they have access to alternative, positive activities. This research aimed to explore the lived experiences of a group of young people who participate in dance classes at a community dance project in the Western Cape. The sample group consisted of four young people between the ages of 16 and 20. Semi-structured interviews were conducted with the participants and the interviews were analysed using interpretative phenomenological analysis. Three major themes emerged from the data, namely 1) My exposure to dance - The impact of context, 2) What motivates me to continue attending classes - The fulfilment of the three basic psychological needs, and 3) How does dance make me feel - The experience of emotional well-being through dance. The discussion of the findings yielded many similarities between the experiences of the participants and the relevant literature. Further, it appears that all four participants experience the satisfaction of the three basic psychological needs (competence, autonomy and relatedness) at the centre. This may serve as a motivator to continue attending classes as well as contribute to sustained eudaimonic wellbeing. Recommendations include further studies being conducted with groups of young people engaging in dance projects in different socioeconomic contexts and in different parts of South Africa. This could give us a more rounded understanding of how people young people experience dance class and how it contributes to emotional well-being. Further research could also be conducted with recreational projects that offer other activities in under-resourced areas in order to better inform the development of such recreational activities.
- Full Text:
Data compression, field of interest shaping and fast algorithms for direction-dependent deconvolution in radio interferometry
- Authors: Atemkeng, Marcellin T
- Date: 2017
- Subjects: Radio astronomy , Solar radio emission , Radio interferometers , Signal processing -- Digital techniques , Algorithms , Data compression (Computer science)
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/6324 , vital:21089
- Description: In radio interferometry, observed visibilities are intrinsically sampled at some interval in time and frequency. Modern interferometers are capable of producing data at very high time and frequency resolution; practical limits on storage and computation costs require that some form of data compression be imposed. The traditional form of compression is simple averaging of the visibilities over coarser time and frequency bins. This has an undesired side effect: the resulting averaged visibilities “decorrelate”, and do so differently depending on the baseline length and averaging interval. This translates into a non-trivial signature in the image domain known as “smearing”, which manifests itself as an attenuation in amplitude towards off-centre sources. With the increasing fields of view and/or longer baselines employed in modern and future instruments, the trade-off between data rate and smearing becomes increasingly unfavourable. Averaging also results in baseline length and a position-dependent point spread function (PSF). In this work, we investigate alternative approaches to low-loss data compression. We show that averaging of the visibility data can be understood as a form of convolution by a boxcar-like window function, and that by employing alternative baseline-dependent window functions a more optimal interferometer smearing response may be induced. Specifically, we can improve amplitude response over a chosen field of interest and attenuate sources outside the field of interest. The main cost of this technique is a reduction in nominal sensitivity; we investigate the smearing vs. sensitivity trade-off and show that in certain regimes a favourable compromise can be achieved. We show the application of this technique to simulated data from the Jansky Very Large Array and the European Very Long Baseline Interferometry Network. Furthermore, we show that the position-dependent PSF shape induced by averaging can be approximated using linear algebraic properties to effectively reduce the computational complexity for evaluating the PSF at each sky position. We conclude by implementing a position-dependent PSF deconvolution in an imaging and deconvolution framework. Using the Low-Frequency Array radio interferometer, we show that deconvolution with position-dependent PSFs results in higher image fidelity compared to a simple CLEAN algorithm and its derivatives.
- Full Text:
- Authors: Atemkeng, Marcellin T
- Date: 2017
- Subjects: Radio astronomy , Solar radio emission , Radio interferometers , Signal processing -- Digital techniques , Algorithms , Data compression (Computer science)
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/6324 , vital:21089
- Description: In radio interferometry, observed visibilities are intrinsically sampled at some interval in time and frequency. Modern interferometers are capable of producing data at very high time and frequency resolution; practical limits on storage and computation costs require that some form of data compression be imposed. The traditional form of compression is simple averaging of the visibilities over coarser time and frequency bins. This has an undesired side effect: the resulting averaged visibilities “decorrelate”, and do so differently depending on the baseline length and averaging interval. This translates into a non-trivial signature in the image domain known as “smearing”, which manifests itself as an attenuation in amplitude towards off-centre sources. With the increasing fields of view and/or longer baselines employed in modern and future instruments, the trade-off between data rate and smearing becomes increasingly unfavourable. Averaging also results in baseline length and a position-dependent point spread function (PSF). In this work, we investigate alternative approaches to low-loss data compression. We show that averaging of the visibility data can be understood as a form of convolution by a boxcar-like window function, and that by employing alternative baseline-dependent window functions a more optimal interferometer smearing response may be induced. Specifically, we can improve amplitude response over a chosen field of interest and attenuate sources outside the field of interest. The main cost of this technique is a reduction in nominal sensitivity; we investigate the smearing vs. sensitivity trade-off and show that in certain regimes a favourable compromise can be achieved. We show the application of this technique to simulated data from the Jansky Very Large Array and the European Very Long Baseline Interferometry Network. Furthermore, we show that the position-dependent PSF shape induced by averaging can be approximated using linear algebraic properties to effectively reduce the computational complexity for evaluating the PSF at each sky position. We conclude by implementing a position-dependent PSF deconvolution in an imaging and deconvolution framework. Using the Low-Frequency Array radio interferometer, we show that deconvolution with position-dependent PSFs results in higher image fidelity compared to a simple CLEAN algorithm and its derivatives.
- Full Text:
Demobilisation and the civilian reintegration of women ex-combatants in post-apartheid South Africa: the aftermath of transnational guerrilla girls, combative mothers and in- betweeners in the shadows of a late twentieth-century war
- Authors: Magadla, Siphokazi
- Date: 2017
- Subjects: South Africa. National Defence Force , Umkhonto we Sizwe (South Africa) -- Demobilization , Azanian People's Liberation Army -- Demobilization , Amabutho Self-Defence Unit -- Demobilization , South Africa. Army -- Women , Women soldiers -- South Africa , Government, Resistance to -- South Africa -- History , Women veterans -- South Africa -- History , Women veterans -- South Africa -- Interviews
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/41775 , vital:25133
- Description: This study examines the state assisted demobilisation and civilian reintegration of women excombatants in post-apartheid South Africa. The study is based on life history interviews conducted with 36 women who fought for Umkhonto we Sizwe (MK), Azanian People’s Liberation Army (APLA) and Amabutho Self-Defence Unit. There is agreement across the literature that the armed struggle against apartheid falls within the category of guerilla warfare, fought in multiple terrains, that blur conventional distinctions of civilian and combatant, homefront and battlefront, as well as the domestic and transnational. Located within feminist International Relations theory, the study argues that the formal process that led to the integration of statutory and non-statutory forces to form the South African National Defence Force, which facilitated the demobilisation process, was framed in ways that did not reflect the unconventional nature of the armed struggle against apartheid. The few women who participated in this process were the transnationally trained combatants of MK and APLA. The majority of women who participated in the multiple and overlapping sites of the domestic and international apartheid battlefront were left out of this process. It is argued that women’s roles in the armed struggle were shaped by various factors, such as age, space and period of struggle. Three categories, guerilla girls, combative mothers and the in-betweeners, are introduced in order to demonstrate the different spaces from within which women fought, and the methods they used, all of which were central to the success of the People’s War strategy. In this regard, the venerated transnationally trained woman combatant, like their male counterpart, is argued to be an exception, as the majority of women were thrust into the armed struggle without military training. Furthermore, it is argued that conservative feminist readings of black women’s relationship with nationalism in the anti-apartheid struggle have misrecognised and undermined women’s combatant contributions, by inscribing their forms of resistance as maternal, and outside the war effort. The study shows that the majority of women combatants have transitioned to civilian life without formal state recognition and assistance. The erasure of women’s role as combatants also means that they are excluded from the current legislative framework facilitated by the Department of Military Veterans to support the welfare of former combatants. As such, the study builds on Jacklyn Cock’s (1991) pioneering study on war and gender in South Africa; it is the first study that exclusively focuses on women ex-combatants’ experiences in postapartheid South Africa.
- Full Text:
- Authors: Magadla, Siphokazi
- Date: 2017
- Subjects: South Africa. National Defence Force , Umkhonto we Sizwe (South Africa) -- Demobilization , Azanian People's Liberation Army -- Demobilization , Amabutho Self-Defence Unit -- Demobilization , South Africa. Army -- Women , Women soldiers -- South Africa , Government, Resistance to -- South Africa -- History , Women veterans -- South Africa -- History , Women veterans -- South Africa -- Interviews
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/41775 , vital:25133
- Description: This study examines the state assisted demobilisation and civilian reintegration of women excombatants in post-apartheid South Africa. The study is based on life history interviews conducted with 36 women who fought for Umkhonto we Sizwe (MK), Azanian People’s Liberation Army (APLA) and Amabutho Self-Defence Unit. There is agreement across the literature that the armed struggle against apartheid falls within the category of guerilla warfare, fought in multiple terrains, that blur conventional distinctions of civilian and combatant, homefront and battlefront, as well as the domestic and transnational. Located within feminist International Relations theory, the study argues that the formal process that led to the integration of statutory and non-statutory forces to form the South African National Defence Force, which facilitated the demobilisation process, was framed in ways that did not reflect the unconventional nature of the armed struggle against apartheid. The few women who participated in this process were the transnationally trained combatants of MK and APLA. The majority of women who participated in the multiple and overlapping sites of the domestic and international apartheid battlefront were left out of this process. It is argued that women’s roles in the armed struggle were shaped by various factors, such as age, space and period of struggle. Three categories, guerilla girls, combative mothers and the in-betweeners, are introduced in order to demonstrate the different spaces from within which women fought, and the methods they used, all of which were central to the success of the People’s War strategy. In this regard, the venerated transnationally trained woman combatant, like their male counterpart, is argued to be an exception, as the majority of women were thrust into the armed struggle without military training. Furthermore, it is argued that conservative feminist readings of black women’s relationship with nationalism in the anti-apartheid struggle have misrecognised and undermined women’s combatant contributions, by inscribing their forms of resistance as maternal, and outside the war effort. The study shows that the majority of women combatants have transitioned to civilian life without formal state recognition and assistance. The erasure of women’s role as combatants also means that they are excluded from the current legislative framework facilitated by the Department of Military Veterans to support the welfare of former combatants. As such, the study builds on Jacklyn Cock’s (1991) pioneering study on war and gender in South Africa; it is the first study that exclusively focuses on women ex-combatants’ experiences in postapartheid South Africa.
- Full Text:
Density-dependent effects on body size, Philopatry, and dispersal in the Damaraland mole-rat (Fukomys damarensis)
- Authors: Finn, Kyle T
- Date: 2017
- Subjects: Fukomys damarensis , Fukomys damarensis -- Reproduction , Fukomys damarensis -- Growth , Rodents -- Reproduction -- South Africa -- Northern Cape , Rodents -- Growth -- South Africa -- Northern Cape , Rodent populations -- South Africa -- Northern Cape
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/50495 , vital:25993
- Description: Population density may exert changes in a variety of behavioural and physiological characters in animals. However, the effects of density-dependence and dispersal are poorly studied in subterranean rodents due to the difficulties involved in observing such effects in wild populations. Using the cooperative breeding Damaraland mole-rat (Fukomys damarensis) as a model species, the effects of population density on body size, growth rates, group size, recruitment, philopatry and dispersal were investigated at two sites (one with low density and one with high density) in the Northern Cape of South Africa. Group size, litter size and the probability of recapture were independent of population density. However, individual body size, recruitment, dispersal rate and dispersal distance were density-dependent. Individuals were significantly larger, juveniles exhibited a significantly higher growth rate, and juvenile recruitment was significantly greater when population density was low. At higher densities, significantly more individuals were lost between capture events which may be indicative of increased rates of dispersal. Mean dispersal distances in mole-rats were reduced at higher densities and increased at lower densities. While both sexes dispersed equally, males were significantly more likely to join an established colony and females created new burrow systems. In addition, four times as many single females were found when population density was low. The apparent differences in the study populations may be attributed to variable annual rainfall or food availability. The greater annual rainfall at the high-density site may provide better habitat conditions and therefore result in an increase in the population density and an increased dispersal rate due to the relaxed ecological constraints such as reduced energetic costs to burrowing. However, the larger body size found at the low-density site may indicate that the available food at that location is of better quality. This study revealed that mole-rats were able to disperse over 1km and therefore a much larger study area would be required in capture-mark-recapture studies to ensure the recapture of the majority of dispersers. Lastly, a surprising find of this study was that females may survive a solitary existence for over two years while awaiting the arrival of a mate.
- Full Text:
- Authors: Finn, Kyle T
- Date: 2017
- Subjects: Fukomys damarensis , Fukomys damarensis -- Reproduction , Fukomys damarensis -- Growth , Rodents -- Reproduction -- South Africa -- Northern Cape , Rodents -- Growth -- South Africa -- Northern Cape , Rodent populations -- South Africa -- Northern Cape
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/50495 , vital:25993
- Description: Population density may exert changes in a variety of behavioural and physiological characters in animals. However, the effects of density-dependence and dispersal are poorly studied in subterranean rodents due to the difficulties involved in observing such effects in wild populations. Using the cooperative breeding Damaraland mole-rat (Fukomys damarensis) as a model species, the effects of population density on body size, growth rates, group size, recruitment, philopatry and dispersal were investigated at two sites (one with low density and one with high density) in the Northern Cape of South Africa. Group size, litter size and the probability of recapture were independent of population density. However, individual body size, recruitment, dispersal rate and dispersal distance were density-dependent. Individuals were significantly larger, juveniles exhibited a significantly higher growth rate, and juvenile recruitment was significantly greater when population density was low. At higher densities, significantly more individuals were lost between capture events which may be indicative of increased rates of dispersal. Mean dispersal distances in mole-rats were reduced at higher densities and increased at lower densities. While both sexes dispersed equally, males were significantly more likely to join an established colony and females created new burrow systems. In addition, four times as many single females were found when population density was low. The apparent differences in the study populations may be attributed to variable annual rainfall or food availability. The greater annual rainfall at the high-density site may provide better habitat conditions and therefore result in an increase in the population density and an increased dispersal rate due to the relaxed ecological constraints such as reduced energetic costs to burrowing. However, the larger body size found at the low-density site may indicate that the available food at that location is of better quality. This study revealed that mole-rats were able to disperse over 1km and therefore a much larger study area would be required in capture-mark-recapture studies to ensure the recapture of the majority of dispersers. Lastly, a surprising find of this study was that females may survive a solitary existence for over two years while awaiting the arrival of a mate.
- Full Text:
Deriving norms for learners in the disadvantaged schools of the peri-urban areas of the Eastern Cape: the case of the Vassiliou Mathematics Proficiency Test (VASSI)
- Masango, Siphesihle Polkadot
- Authors: Masango, Siphesihle Polkadot
- Date: 2017
- Subjects: VASSI Mathematics Proficiency Test , Mathematical ability -- Testing -- South Africa , Educational tests and measurements -- South Africa , Children with social disabilities -- Education -- South Africa , Children with social disabilities -- Education -- South Africa -- Makhanda -- Case studies
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/49929 , vital:25943
- Description: This study builds on South African cross-cultural research which highlights the need for careful stratification of normative samples for quality of education and geographical location. The aim of the present study was to produce an expanded set of preliminary norms for learners in the disadvantaged schools of the peri-urban areas of the Eastern Cape, Grahamstown, on the Vassiliou Mathematics Foundation Phase Test (VASSI) and Vassiliou Mathematics Proficiency Test (VASSI), respectively. The test was administered to Grade 1-6 learners in four different schools all within Joza location, Grahamstown. For the learners’ convenience the tests were translated into isiXhosa, the translations were provided together with the original English questions. Archival data collected by honours students was also incorporated in this study. The total number of participants was N=724 which was comprised of 147 grade 1s, 123 grade 2s, 117 grade 3s, 128 grade 4s, 113 grade 5s and 96 grade 6s. Norm-referenced criterion was used in analysing the data. The results of this study are in accordance with those purporting the low performance of disadvantaged learners on the school subject, mathematics. Stanines for the various grades (Grade 1 to 6) were calculated and are presented in the study. This study has demonstrated that although gender, language and other ethnic variables have an impact on mathematics performance, quality of education and socioeconomic status have a significant effect. Further research is needed on the effect of quality of education and socioeconomic status on learners in disadvantaged schools on this test in particular.
- Full Text:
- Authors: Masango, Siphesihle Polkadot
- Date: 2017
- Subjects: VASSI Mathematics Proficiency Test , Mathematical ability -- Testing -- South Africa , Educational tests and measurements -- South Africa , Children with social disabilities -- Education -- South Africa , Children with social disabilities -- Education -- South Africa -- Makhanda -- Case studies
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/49929 , vital:25943
- Description: This study builds on South African cross-cultural research which highlights the need for careful stratification of normative samples for quality of education and geographical location. The aim of the present study was to produce an expanded set of preliminary norms for learners in the disadvantaged schools of the peri-urban areas of the Eastern Cape, Grahamstown, on the Vassiliou Mathematics Foundation Phase Test (VASSI) and Vassiliou Mathematics Proficiency Test (VASSI), respectively. The test was administered to Grade 1-6 learners in four different schools all within Joza location, Grahamstown. For the learners’ convenience the tests were translated into isiXhosa, the translations were provided together with the original English questions. Archival data collected by honours students was also incorporated in this study. The total number of participants was N=724 which was comprised of 147 grade 1s, 123 grade 2s, 117 grade 3s, 128 grade 4s, 113 grade 5s and 96 grade 6s. Norm-referenced criterion was used in analysing the data. The results of this study are in accordance with those purporting the low performance of disadvantaged learners on the school subject, mathematics. Stanines for the various grades (Grade 1 to 6) were calculated and are presented in the study. This study has demonstrated that although gender, language and other ethnic variables have an impact on mathematics performance, quality of education and socioeconomic status have a significant effect. Further research is needed on the effect of quality of education and socioeconomic status on learners in disadvantaged schools on this test in particular.
- Full Text:
Development and assessment of ketoconazole intravaginal thermosetting hydrogel formulations
- Authors: Ramanah, Ashmita
- Date: 2017
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/5198 , vital:20785
- Description: Imidazole compounds are commonly used as antifungal therapies and ketoconazole was the first broad spectrum orally active azole identified and registered. However, the risks of hepatotoxicity and drug interactions following systemic delivery and absorption of ketoconazole outweigh the therapeutic benefits and ketoconazole was therefore discontinued as first line systemic antifungal therapy in many countries. Although not yet banned in South Africa, the South African Medicine Formulary has ceased to recommend the use of ketoconazole for systemic treatment. Topical use of ketoconazole is, however, regarded as safe following extensive human use as low systemic absorption occurs following topical administration. Vulvo-vaginal candidiasis is a yeast infection that affects a large number of women, some of whom present with several infections annually. The topical treatment options for vulvo-vaginal candidiasis include the use of vaginal tablets, capsules, ovules and creams administered as a single dose or one to three times daily for three to fourteen days either alone or in combination with another dosage form depending on the regimen. Administration of the dose nightly is recommended for most vaginal creams and ovule formulation due to leakage and the uncomfortable feel of the dosage form if administered during the day. A thermosetting gel that remains in the vagina following administration and prolongs the release of ketoconazole from a once daily dose would be a useful addition to the arsenal for intra-vaginal antifungal therapy. Thermosetting gels would be more comfortable to administer as the gel would set in a form similar to naturally occurring mucous in the vagina and, if formulated with a low pH, irritation of the sensitive and fissured tissue would be minimised. A further benefit would be that once set the gel would loosely take on the anatomical shape of the vagina. A simple, precise, accurate, reproducible and sensitive stability-indicating reversed phase-high performance liquid chromatographic method using ultraviolet detection for the quantitation of ketoconazole was developed and validated. The method was specific and was applied to the determination of ketoconazole in commercial and experimental formulations in addition to samples from degradation studies and in vitro release testing. Product performance characteristics of commercial products were investigated with the goal to provide a strategy for the development of a novel intra vaginal gel in the shortest possible time. Characterisation of Xolegel®, Kez® shampoo and Ketazol® cream included an evaluation of pH, viscosity and assay, in addition to spectroscopic and thermal analysis, to identify ideal characteristics of topical products that could be used as targets during formulation development of the gel. An in vitro release method was developed and validated for precision and accuracy and the in vitro release profiles of commercial ketoconazole products were compared using analysis of variance, model dependent and independent approaches. Ketoconazole release data from test gel manufactured during formulation development were investigated to obtain information about the relationship between formulation content and drug release. Poloxamers marketed as Pluronic® and Lutrol® are synthetic non-ionic tri-block copolymers that consist of hydrophobic propylene oxide and hydrophilic polyethylene oxide blocks, which in solution interact to exhibit thermo-reversible behaviour. In situ forming hydrogels consisting of poloxamers, more specifically poloxamer 407, are activated following a temperature stimulus and undergo a sol to gel transition. This approach was used to produce a thermosetting vaginal gel that would exhibit a long residence time in the vagina with an associated enhancement of therapeutic efficacy. Ketoconazole- excipient compatibility was investigated during preformulation studies using spectroscopic and thermal analysis to enable the selection of excipients best suited for the production of a novel dosage form prior to formulation development activities. No obvious interactions between ketoconazole and excipient were observed and ketoconazole was found in an amorphous form when in combination with polysorbate 80 and poloxamers. A two-level factorial design was used to produce solvent systems with different amounts of polysorbate 80, citric acid and ethanol to identify a vehicle in which ketoconazole exhibited optimum solubility and at a pH that would be least irritating to the vaginal mucosa with a low content of excipients. The optimised vehicle consisted of 4% m/v citric acid, 1.5% v/v polysorbate 80 and 9.5% v/v ethanol made up to 50 g with citrate-phosphate buffer adjusted to pH 5.0, resulted in a vehicle of pH of 3.5 in which 71.41 mg of ketoconazole was dissolved per mL. A Central Composite Design was used to evaluate compositions for the modulation of viscosity of the thermosetting dosage form such that it was a liquid at 22 °C that rapidly formed a stiff gel when heated to 37 °C (intra-vaginal temperature) using different amounts of the poloxamer grades 407, 188 and 237. Thermosetting gels containing 2% m/v ketoconazole were manufactured using specifications generated using the Central Composite Design and the viscosity at 22 °C and 37 °C, solution to gel transition time, potency and ketoconazole release at 24, 48 and 72 hours investigated. Contour and three-dimensional response surface plots and mathematical relationships with target ranges set for responses were identified and with the aid of Central Composite Design the optimisation of a desirable thermosetting gel was achieved. The optimised composition included 16% m/v poloxamer 407, 10% m/v poloxamer 188 and 6% m/v poloxamer 237 in the gel that was used as the basis for further optimisation studies. The low ketoconazole release for ketoconazole observed indicated that the poloxamers had formed a gel matrix that sustained the release of ketoconazole and would therefore ensure that once daily administration of the gel was possible. The sol-gel transition test may be used as a simple and cheap alternative to viscosity testing for thermosetting formulations when expensive viscometers and rheometers are unavailable and was successfully used for this purpose.Ketoconazole is photolabile and is prone to degradation in aqueous solutions. The hydrophobic core of micelles formed in these dosage forms are believed to shield ketoconazole molecules and improve stability in aqueous solutions and acidic gels. The thermosetting gel optimised for poloxamer content was subjected to a further Central Composite Design in which sodium metabisulphite content and vehicle pH were investigated. The length of storage was used as a numeric variable and storage condition as a categoric variable at two levels to monitor the stability of the gels. The formulations were investigated at sample times of 0, 1, 2, 4 and 8 weeks at 5 °C, 25 °C and 40 °C. The use of a Central Composite Design facilitated an understanding of the interactions between input variables and their impact on the responses analysed including ketoconazole content, release at 24, 48 and 72 hours, gel pH and viscosity at 22 °C and 37 °C. Design of Experiments may be used as a rapid cost effective tool for an overall assessment of the stability of novel topical dosage forms. However, a more thorough assessment of stability may be required for product registration. Ketoconazole was found to be unstable in the acidic thermosetting gels despite the addition of antioxidant. The gels in liquid form at 5 °C and 25 °C have a low number of micelles for ketoconazole incorporation and therefore additional optimisation studies would be required to enhance the shelf-life of this product.
- Full Text:
- Authors: Ramanah, Ashmita
- Date: 2017
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/5198 , vital:20785
- Description: Imidazole compounds are commonly used as antifungal therapies and ketoconazole was the first broad spectrum orally active azole identified and registered. However, the risks of hepatotoxicity and drug interactions following systemic delivery and absorption of ketoconazole outweigh the therapeutic benefits and ketoconazole was therefore discontinued as first line systemic antifungal therapy in many countries. Although not yet banned in South Africa, the South African Medicine Formulary has ceased to recommend the use of ketoconazole for systemic treatment. Topical use of ketoconazole is, however, regarded as safe following extensive human use as low systemic absorption occurs following topical administration. Vulvo-vaginal candidiasis is a yeast infection that affects a large number of women, some of whom present with several infections annually. The topical treatment options for vulvo-vaginal candidiasis include the use of vaginal tablets, capsules, ovules and creams administered as a single dose or one to three times daily for three to fourteen days either alone or in combination with another dosage form depending on the regimen. Administration of the dose nightly is recommended for most vaginal creams and ovule formulation due to leakage and the uncomfortable feel of the dosage form if administered during the day. A thermosetting gel that remains in the vagina following administration and prolongs the release of ketoconazole from a once daily dose would be a useful addition to the arsenal for intra-vaginal antifungal therapy. Thermosetting gels would be more comfortable to administer as the gel would set in a form similar to naturally occurring mucous in the vagina and, if formulated with a low pH, irritation of the sensitive and fissured tissue would be minimised. A further benefit would be that once set the gel would loosely take on the anatomical shape of the vagina. A simple, precise, accurate, reproducible and sensitive stability-indicating reversed phase-high performance liquid chromatographic method using ultraviolet detection for the quantitation of ketoconazole was developed and validated. The method was specific and was applied to the determination of ketoconazole in commercial and experimental formulations in addition to samples from degradation studies and in vitro release testing. Product performance characteristics of commercial products were investigated with the goal to provide a strategy for the development of a novel intra vaginal gel in the shortest possible time. Characterisation of Xolegel®, Kez® shampoo and Ketazol® cream included an evaluation of pH, viscosity and assay, in addition to spectroscopic and thermal analysis, to identify ideal characteristics of topical products that could be used as targets during formulation development of the gel. An in vitro release method was developed and validated for precision and accuracy and the in vitro release profiles of commercial ketoconazole products were compared using analysis of variance, model dependent and independent approaches. Ketoconazole release data from test gel manufactured during formulation development were investigated to obtain information about the relationship between formulation content and drug release. Poloxamers marketed as Pluronic® and Lutrol® are synthetic non-ionic tri-block copolymers that consist of hydrophobic propylene oxide and hydrophilic polyethylene oxide blocks, which in solution interact to exhibit thermo-reversible behaviour. In situ forming hydrogels consisting of poloxamers, more specifically poloxamer 407, are activated following a temperature stimulus and undergo a sol to gel transition. This approach was used to produce a thermosetting vaginal gel that would exhibit a long residence time in the vagina with an associated enhancement of therapeutic efficacy. Ketoconazole- excipient compatibility was investigated during preformulation studies using spectroscopic and thermal analysis to enable the selection of excipients best suited for the production of a novel dosage form prior to formulation development activities. No obvious interactions between ketoconazole and excipient were observed and ketoconazole was found in an amorphous form when in combination with polysorbate 80 and poloxamers. A two-level factorial design was used to produce solvent systems with different amounts of polysorbate 80, citric acid and ethanol to identify a vehicle in which ketoconazole exhibited optimum solubility and at a pH that would be least irritating to the vaginal mucosa with a low content of excipients. The optimised vehicle consisted of 4% m/v citric acid, 1.5% v/v polysorbate 80 and 9.5% v/v ethanol made up to 50 g with citrate-phosphate buffer adjusted to pH 5.0, resulted in a vehicle of pH of 3.5 in which 71.41 mg of ketoconazole was dissolved per mL. A Central Composite Design was used to evaluate compositions for the modulation of viscosity of the thermosetting dosage form such that it was a liquid at 22 °C that rapidly formed a stiff gel when heated to 37 °C (intra-vaginal temperature) using different amounts of the poloxamer grades 407, 188 and 237. Thermosetting gels containing 2% m/v ketoconazole were manufactured using specifications generated using the Central Composite Design and the viscosity at 22 °C and 37 °C, solution to gel transition time, potency and ketoconazole release at 24, 48 and 72 hours investigated. Contour and three-dimensional response surface plots and mathematical relationships with target ranges set for responses were identified and with the aid of Central Composite Design the optimisation of a desirable thermosetting gel was achieved. The optimised composition included 16% m/v poloxamer 407, 10% m/v poloxamer 188 and 6% m/v poloxamer 237 in the gel that was used as the basis for further optimisation studies. The low ketoconazole release for ketoconazole observed indicated that the poloxamers had formed a gel matrix that sustained the release of ketoconazole and would therefore ensure that once daily administration of the gel was possible. The sol-gel transition test may be used as a simple and cheap alternative to viscosity testing for thermosetting formulations when expensive viscometers and rheometers are unavailable and was successfully used for this purpose.Ketoconazole is photolabile and is prone to degradation in aqueous solutions. The hydrophobic core of micelles formed in these dosage forms are believed to shield ketoconazole molecules and improve stability in aqueous solutions and acidic gels. The thermosetting gel optimised for poloxamer content was subjected to a further Central Composite Design in which sodium metabisulphite content and vehicle pH were investigated. The length of storage was used as a numeric variable and storage condition as a categoric variable at two levels to monitor the stability of the gels. The formulations were investigated at sample times of 0, 1, 2, 4 and 8 weeks at 5 °C, 25 °C and 40 °C. The use of a Central Composite Design facilitated an understanding of the interactions between input variables and their impact on the responses analysed including ketoconazole content, release at 24, 48 and 72 hours, gel pH and viscosity at 22 °C and 37 °C. Design of Experiments may be used as a rapid cost effective tool for an overall assessment of the stability of novel topical dosage forms. However, a more thorough assessment of stability may be required for product registration. Ketoconazole was found to be unstable in the acidic thermosetting gels despite the addition of antioxidant. The gels in liquid form at 5 °C and 25 °C have a low number of micelles for ketoconazole incorporation and therefore additional optimisation studies would be required to enhance the shelf-life of this product.
- Full Text:
Development and implementation of health promotion activities for the prevention of adolescent pregnancies
- Authors: Chemuru, Nomsa Rutendo
- Date: 2017
- Subjects: Teenage pregnancy -- South Africa -- Makhanda , Teenage pregnancy -- Prevention -- South Africa -- Makhanda
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10962/5115 , vital:20776
- Description: Of the eight Millennium Development Goals (MDGs) established in 2000 by the World Health Organisation, Millennium Development Goals 5 aimed at improving maternal health by addressing the high maternal mortality rate and increasing universal access to reproductive health by 2015.Adolescent pregnancy contributes to maternal, perinatal and infant mortality and also worsens the empowerment of young girls by negatively affecting their physical, educational, social, and economic development.This is a pressing public health concern in South Africa. The reduction of adolescent pregnancy is vital for achieving the sustainable human, health social and economic development of society at large. Culturally sensitive interventions to prevent adolescent pregnancies not only integrate the communities' norms, values, practices and behavioural patterns into the intervention's design and implementation but also the historical, social and economic contexts in which they exist. Progress has been made on the research on health promotion and education in South Africa; however communities are often not consulted on the design and conduct of health promotion research projects.The aim of the study was to develop and implement culturally sensitive and appropriate health promotion activities for the prevention of adolescent pregnancy in Grahamstown, Glenmore and Ndwayana communities in the Eastern Cape, South Africa.Two community based organisations and community care workers associated with them participated in this Community Based Participatory Research using the PEN-3 cultural model. The first phase of this study involved semi-structured interviews carried out with 14 community care workers to identify factors and consequences of adolescent pregnancies in their respective communities. The audio-recorded interviews were transcribed and coded using NVivo® 2010 software. The PEN 3 cultural model was adopted in the studyto address the socio-cultural factors contributing to adolescent pregnancy in the communities. The second phase involved a series of interactive workshops with CCWs for a participatory development of the facilitator's manual. Responses from CCWs informed the design of this study's intervention strategies. A facilitator's manual was developed to implement health promotion intervention, leading to the third phase of this study. The guided implementationof the health promotion intervention for the prevention of adolescent pregnancy was carried out over a period of 14 months and evaluated in the final phase of the study. The facilitator's manual was modified based on feedback fromCCWs, on possible improvements and cultural appropriateness. Readability testing guided the final modification of the manual. According to the community care workers, there were a number of adolescents who fell pregnant in their communities each year. The CCWs identified the influence of family members, friends and other stakeholders as contributory factors to adolescent pregnancy. They identified the lack of parental support in informing and educating adolescents about sexual health. Adolescents themselves lacked the maturity to recognise the risks and consequences of adolescent pregnancy. The negative perceptions of contraception in the community were discouraging contraceptive use amongst the adolescents. However, the results showed that enablers such as home and school visits done by the community care workers can be utilised to prevent adolescent pregnancy. Other factors included lack of health promotion materials and activities with information about preventing of adolescent pregnancy, and if available, the material is in English, that the adolescents may not comprehend. Socio-economic factors such as poverty, the Child Support Grant, cross generational relationships and coerced sex further contributed to adolescent pregnancy in the communities.CCWs identified the need for a more comprehensive health promotion intervention to prevent of adolescent pregnancy. A facilitator's manual addressing the prevention of adolescent pregnancy was developed and modified through a series participatory workshops with the community care workers.The facilitator's manual was used by CCWs to conducthealth promotion activities encouraging the prevention of adolescent pregnancies within the community's clinics, schools and during home visits. Community based participatory research methods and the PEN-3cultural model were used to develop this culturally sensitive and community specific adolescent pregnancy intervention for and by the CCWs. The participatory development of the facilitator's manual and the regular interactive workshops with the CCWs were strengthened by embedding this project into the development programs of the two non-governmental organisations contributing to sustainable development programs for women and children.
- Full Text:
- Authors: Chemuru, Nomsa Rutendo
- Date: 2017
- Subjects: Teenage pregnancy -- South Africa -- Makhanda , Teenage pregnancy -- Prevention -- South Africa -- Makhanda
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10962/5115 , vital:20776
- Description: Of the eight Millennium Development Goals (MDGs) established in 2000 by the World Health Organisation, Millennium Development Goals 5 aimed at improving maternal health by addressing the high maternal mortality rate and increasing universal access to reproductive health by 2015.Adolescent pregnancy contributes to maternal, perinatal and infant mortality and also worsens the empowerment of young girls by negatively affecting their physical, educational, social, and economic development.This is a pressing public health concern in South Africa. The reduction of adolescent pregnancy is vital for achieving the sustainable human, health social and economic development of society at large. Culturally sensitive interventions to prevent adolescent pregnancies not only integrate the communities' norms, values, practices and behavioural patterns into the intervention's design and implementation but also the historical, social and economic contexts in which they exist. Progress has been made on the research on health promotion and education in South Africa; however communities are often not consulted on the design and conduct of health promotion research projects.The aim of the study was to develop and implement culturally sensitive and appropriate health promotion activities for the prevention of adolescent pregnancy in Grahamstown, Glenmore and Ndwayana communities in the Eastern Cape, South Africa.Two community based organisations and community care workers associated with them participated in this Community Based Participatory Research using the PEN-3 cultural model. The first phase of this study involved semi-structured interviews carried out with 14 community care workers to identify factors and consequences of adolescent pregnancies in their respective communities. The audio-recorded interviews were transcribed and coded using NVivo® 2010 software. The PEN 3 cultural model was adopted in the studyto address the socio-cultural factors contributing to adolescent pregnancy in the communities. The second phase involved a series of interactive workshops with CCWs for a participatory development of the facilitator's manual. Responses from CCWs informed the design of this study's intervention strategies. A facilitator's manual was developed to implement health promotion intervention, leading to the third phase of this study. The guided implementationof the health promotion intervention for the prevention of adolescent pregnancy was carried out over a period of 14 months and evaluated in the final phase of the study. The facilitator's manual was modified based on feedback fromCCWs, on possible improvements and cultural appropriateness. Readability testing guided the final modification of the manual. According to the community care workers, there were a number of adolescents who fell pregnant in their communities each year. The CCWs identified the influence of family members, friends and other stakeholders as contributory factors to adolescent pregnancy. They identified the lack of parental support in informing and educating adolescents about sexual health. Adolescents themselves lacked the maturity to recognise the risks and consequences of adolescent pregnancy. The negative perceptions of contraception in the community were discouraging contraceptive use amongst the adolescents. However, the results showed that enablers such as home and school visits done by the community care workers can be utilised to prevent adolescent pregnancy. Other factors included lack of health promotion materials and activities with information about preventing of adolescent pregnancy, and if available, the material is in English, that the adolescents may not comprehend. Socio-economic factors such as poverty, the Child Support Grant, cross generational relationships and coerced sex further contributed to adolescent pregnancy in the communities.CCWs identified the need for a more comprehensive health promotion intervention to prevent of adolescent pregnancy. A facilitator's manual addressing the prevention of adolescent pregnancy was developed and modified through a series participatory workshops with the community care workers.The facilitator's manual was used by CCWs to conducthealth promotion activities encouraging the prevention of adolescent pregnancies within the community's clinics, schools and during home visits. Community based participatory research methods and the PEN-3cultural model were used to develop this culturally sensitive and community specific adolescent pregnancy intervention for and by the CCWs. The participatory development of the facilitator's manual and the regular interactive workshops with the CCWs were strengthened by embedding this project into the development programs of the two non-governmental organisations contributing to sustainable development programs for women and children.
- Full Text:
Development and validation of an In Vitro Release Test (IVRT) to investigate the release of miconazole nitrate from topical cream formulations
- Authors: Purazi, Potiwa
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/65223 , vital:28711
- Description: Expected release date-May 2019
- Full Text:
- Authors: Purazi, Potiwa
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/65223 , vital:28711
- Description: Expected release date-May 2019
- Full Text: