Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study
- Authors: Boateng, Rita A , Tastan Bishop, Özlem , Musyoka, Thommas M
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/429372 , vital:72605 , xlink:href="https://doi.org/10.1186/s12936-020-03512-1"
- Description: Plasmodial transketolase (PTKT) enzyme is one of the novel pharmacological targets being explored as potential anti-malarial drug target due to its functional role and low sequence identity to the human enzyme. Despite this, features contributing to such have not been exploited for anti-malarial drug design. Additionally, there are no anti-malarial drugs targeting PTKTs whereas the broad activity of these inhibitors against PTKTs from other Plasmodium spp. is yet to be reported. This study characterises different PTKTs [Plasmodium falciparum (PfTKT), Plasmodium vivax (PvTKT), Plasmodium ovale (PoTKT), Plasmodium malariae (PmTKT) and Plasmodium knowlesi (PkTKT) and the human homolog (HsTKT)] to identify key sequence and structural based differences as well as the identification of selective potential inhibitors against PTKTs.
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Tracing the Voice of Protest in Selected Oral Literature:
- Authors: Kaschula, Russell H
- Date: 2020
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/174452 , vital:42479 , ISBN 9783030555177
- Description: This chapter aims to present the notion of “protest” as a contested arena in the production of oral literature, against the backdrop of continued and contested sociopolitical change in Africa. This contestation can be politically based, gender based and sometimes even based in religion. The chapter looks specifically at poetry, songs and the folktale to establish how the “voice of protest” has been presented over time in relation to specific African countries such as Senegal, South Africa, Somali, Guinea, Kenya, Tanzania, Malawi, Ethiopia, Nigeria, Zimbabwe and Lesotho. Poetic protest as part of political protest is also discussed. Furthermore, the chapter seeks to explore how this “voice of protest” has been received, both from an audience point of view and from the point of view of those who control power.
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A spatio-temporal, landscape perspective on Acacia dealbata invasions and broader land use and cover changes in the northern Eastern Cape, South Africa
- Authors: Gouws, Aidan J , Prof.Shackleton, Charlie M
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/179670 , vital:43156 , xlink:href="https://doi.org/10.1007/s10661-019-7204-y"
- Description: Biological invasions and human land use both have the potential to drastically alter the patterns and processes of landscapes, driving habitat fragmentation and altering natural disturbance regimes. The proliferation of an invasive species depends on composition and configuration of the landscape, as well as the invasiveness of the species. To effectively manage a highly invasive species, such as Acacia dealbata, it is crucial to understand the historical progression of the invasion within the landscape. This study sought to examine the landscape dynamics of biological invasions by tracking the historical spread of A. dealbata and broader land use/land cover (LULC) changes at different spatiotemporal scales in the northern Eastern Cape. A timeseries of aerial photographs were systematically classified according to designated A. dealbata and LULC categories in ArcGIS to track the changes in the extent and rate of spread of A. dealbata. Markedly dynamic, multi-directional, and spatio-temporally variable LULC transitions were observed across the northern Eastern Cape over the last six decades. A. dealbata frequently retained a high proportion of cover over time, and despite the loss of cover to other LULC classes, a net increase in A. dealbata cover occurred as it spread at an overall annual rate of 0.11–0.21%, occupying approximately 8–18% of land cover across all sampled sites by 2013.
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