Students' perception of pre-exposure prophylaxis as a prevention strategy for reducing HIV/AIDS incidences at Rhodes University
- Authors: Lepelesana, Mamorena Sylvia
- Date: 2024-10-11
- Subjects: Pre-exposure prophylaxis , HIV infections , AIDS (Disease) , College students Attitudes , Stigma (Social psychology) , Rhodes University
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/466150 , vital:76701
- Description: South Africa has the largest number of people living with HIV/AIDS compared to the rest of the world, with young people most at risk. The World Health Organisation (WHO) recommends the use of Pre-Exposure Prophylaxis (PrEP) in key populations at a higher risk of exposure to HIV/AIDS. The HIV/AIDS pandemic remains a pressing issue among higher education institutions, with a need for a comprehensive understanding of barriers and facilitators associated with the use of PrEP. The Higher Education AIDS (HEAIDS) plays a pivotal role in the mitigation of the spread of HIV/AIDS in Higher Education Institutions (HEIs). In this study, Rhodes University serves as a focal point for exploring PrEP implementation and acceptance. This qualitative study examines Rhodes University students' PrEP knowledge, perception, practice, and roll-out preference. More evidence is required to measure progress among students. A study was conducted involving sixteen (16) in-depth semi-structured interviews with students and health care workers, as well as a focus group consisting of three (3) students aged between 20-60 years. This study used the Socio-Ecological Model and Health Belief Model as theoretical frameworks. Participants in the study identified both the barriers and the facilitators to the use of PrEP. The findings show that there is a lack of knowledge and low perception among students about PrEP. The study found that lack of knowledge was the source of the stigma and misconception about PrEP. Most participants expressed the need for more information to differentiate between the ARVs in PrEP and the ARV medication for HIV-positive people. However, they further expressed a willingness to embrace PrEP if they had information about it. The study highlights that the use of PrEP is linked to individual and environmental factors, which are crucial for PrEP roll-out. These factors include access to PrEP in a friendly manner, supportive family and friends, and the reduction of stigma and misconception. Therefore, when addressed, the said factors can foster the use of PrEP and mitigate barriers. For students to fully realise the benefits of HIV/AIDS prevention strategies like PrEP, there is a need for informed educational efforts. A well-informed student body is important for the successful adoption and use of PrEP. The findings suggest that the health care workers were knowledgeable and conscious about the use of PrEP. However, there were inconsistencies in the information provided by the health care workers regarding the recommended period for taking PrEP before testing again and taking the three-month course. The inconsistencies raise questions regarding the accuracy and reliability of the information provided. , Thesis (MSocSci) -- Faculty of Humanities, Sociology, 2024
- Full Text:
- Authors: Lepelesana, Mamorena Sylvia
- Date: 2024-10-11
- Subjects: Pre-exposure prophylaxis , HIV infections , AIDS (Disease) , College students Attitudes , Stigma (Social psychology) , Rhodes University
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/466150 , vital:76701
- Description: South Africa has the largest number of people living with HIV/AIDS compared to the rest of the world, with young people most at risk. The World Health Organisation (WHO) recommends the use of Pre-Exposure Prophylaxis (PrEP) in key populations at a higher risk of exposure to HIV/AIDS. The HIV/AIDS pandemic remains a pressing issue among higher education institutions, with a need for a comprehensive understanding of barriers and facilitators associated with the use of PrEP. The Higher Education AIDS (HEAIDS) plays a pivotal role in the mitigation of the spread of HIV/AIDS in Higher Education Institutions (HEIs). In this study, Rhodes University serves as a focal point for exploring PrEP implementation and acceptance. This qualitative study examines Rhodes University students' PrEP knowledge, perception, practice, and roll-out preference. More evidence is required to measure progress among students. A study was conducted involving sixteen (16) in-depth semi-structured interviews with students and health care workers, as well as a focus group consisting of three (3) students aged between 20-60 years. This study used the Socio-Ecological Model and Health Belief Model as theoretical frameworks. Participants in the study identified both the barriers and the facilitators to the use of PrEP. The findings show that there is a lack of knowledge and low perception among students about PrEP. The study found that lack of knowledge was the source of the stigma and misconception about PrEP. Most participants expressed the need for more information to differentiate between the ARVs in PrEP and the ARV medication for HIV-positive people. However, they further expressed a willingness to embrace PrEP if they had information about it. The study highlights that the use of PrEP is linked to individual and environmental factors, which are crucial for PrEP roll-out. These factors include access to PrEP in a friendly manner, supportive family and friends, and the reduction of stigma and misconception. Therefore, when addressed, the said factors can foster the use of PrEP and mitigate barriers. For students to fully realise the benefits of HIV/AIDS prevention strategies like PrEP, there is a need for informed educational efforts. A well-informed student body is important for the successful adoption and use of PrEP. The findings suggest that the health care workers were knowledgeable and conscious about the use of PrEP. However, there were inconsistencies in the information provided by the health care workers regarding the recommended period for taking PrEP before testing again and taking the three-month course. The inconsistencies raise questions regarding the accuracy and reliability of the information provided. , Thesis (MSocSci) -- Faculty of Humanities, Sociology, 2024
- Full Text:
Studies directed towards the synthesis of chromone carbaldehyde-derived HIV-1 protease inhibitors
- Authors: Molefe, Duduzile Mabel
- Date: 2008
- Subjects: Protease Inhibitors , HIV infections , HIV (Viruses) , AIDS (Disease) , Proteolytic enzymes , Heterocyclic compounds -- Derivatives , Chemical kinetics , Nuclear magnetic resonance spectroscopy
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4526 , http://hdl.handle.net/10962/d1015542
- Description: A series of chromone-3-carbaldehydes have been prepared using Vilsmeier-Haack methodology while a corresponding series of chromone-2-carbaldeydes have been synthesized via the Kostanecki-Robinson reaction. Baylis-Hillman reactions have been conducted on both series of chromone carbaldehydes using three different catalysts, viz., 1,4-diazabicyclo(2.2.2]octane (DABCO), 1,8-diazabicyclo[5.4.0]undec- 7-ene (DBU) and 3-hydroxyquinuclidine (3HQ), and acrylonitrile, methyl acrylate and methyl vinyl ketone as the activated alkenes. These reactions have typically (but not always!) afforded both normal Baylis-Hillman and dimeric products. Attention has also been given to the use of 1-methyl-2-pyrrolidine (1-NMP), an ionic liquid, to replace normal organic solvents, and it has been found that, in the presence of DABCO, chromone-3-carbaldehydes afford the dimeric products alone. Reactions of chromone-3-carbaldehydes with methyl vinyl ketone have yielded unexpected, novel adducts, which appear to arise from preferential attack at C(2) in the chromone nucleus. Research on chromone-2-carbaldeydes under Baylis-Hillman conditions has also resulted in the formation of some interesting products instead of the expected Baylis-Hillman adducts. The Baylis-Hillman products have been explored as substrates for aza-Michael reactions using various amino derivatives including protected amino acids in the presence of the tetrabutylammonium bromide (TBAB) and the ionic liquid, 3-butyl-1- methylimidazoleboranetetrafluoride (BmimBF₄), as catalysts. The aza-Michael products have been targeted as truncated ritonavir analogues for investigation as potential HIV -1 protease inhibitors, and representative compounds have been subjected to enzyme inhibition assays to explore the extent and type of inhibition. Lineweaver-Burk and Dixon plots have indicated competitive inhibition in one case as well as non-competitive inhibition in another, and the inhibition constants (Ki) have been compared with that of the ritonavir. Computer modelling studies have also been conducted on selected chromonecontaining derivatives, using the ACCELRYS Cerius² platform. Interactive docking of the chromone-containing ligands into the HIV -1 protease receptor site, using the Ligandfit module, has indicated the importance of hydrogen-bonding interactions mediated by bridging water molecules situated in the receptor cavity. NMR spectroscopy has been used to elucidate complex and competing mechanistic pathways involved in the Baylis-Hillman reactions of selected 2-nitrobenzaldehydes with MVK in the presence of DABCO - reactions which afford the normal BaylisHillman product, the MVK dimer and syn- and anti-Baylis-Hillman type diadducts. The kinetic data confirm the concomitant operation of two pathways and reveal that, in the initial stage of the reaction, the product distribution is kinetically controlled, whereas in the latter stage, thermodynamic control results in the consumption of the normal Baylis-Hillman product and predominance of the anti-diadduct.
- Full Text:
- Authors: Molefe, Duduzile Mabel
- Date: 2008
- Subjects: Protease Inhibitors , HIV infections , HIV (Viruses) , AIDS (Disease) , Proteolytic enzymes , Heterocyclic compounds -- Derivatives , Chemical kinetics , Nuclear magnetic resonance spectroscopy
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4526 , http://hdl.handle.net/10962/d1015542
- Description: A series of chromone-3-carbaldehydes have been prepared using Vilsmeier-Haack methodology while a corresponding series of chromone-2-carbaldeydes have been synthesized via the Kostanecki-Robinson reaction. Baylis-Hillman reactions have been conducted on both series of chromone carbaldehydes using three different catalysts, viz., 1,4-diazabicyclo(2.2.2]octane (DABCO), 1,8-diazabicyclo[5.4.0]undec- 7-ene (DBU) and 3-hydroxyquinuclidine (3HQ), and acrylonitrile, methyl acrylate and methyl vinyl ketone as the activated alkenes. These reactions have typically (but not always!) afforded both normal Baylis-Hillman and dimeric products. Attention has also been given to the use of 1-methyl-2-pyrrolidine (1-NMP), an ionic liquid, to replace normal organic solvents, and it has been found that, in the presence of DABCO, chromone-3-carbaldehydes afford the dimeric products alone. Reactions of chromone-3-carbaldehydes with methyl vinyl ketone have yielded unexpected, novel adducts, which appear to arise from preferential attack at C(2) in the chromone nucleus. Research on chromone-2-carbaldeydes under Baylis-Hillman conditions has also resulted in the formation of some interesting products instead of the expected Baylis-Hillman adducts. The Baylis-Hillman products have been explored as substrates for aza-Michael reactions using various amino derivatives including protected amino acids in the presence of the tetrabutylammonium bromide (TBAB) and the ionic liquid, 3-butyl-1- methylimidazoleboranetetrafluoride (BmimBF₄), as catalysts. The aza-Michael products have been targeted as truncated ritonavir analogues for investigation as potential HIV -1 protease inhibitors, and representative compounds have been subjected to enzyme inhibition assays to explore the extent and type of inhibition. Lineweaver-Burk and Dixon plots have indicated competitive inhibition in one case as well as non-competitive inhibition in another, and the inhibition constants (Ki) have been compared with that of the ritonavir. Computer modelling studies have also been conducted on selected chromonecontaining derivatives, using the ACCELRYS Cerius² platform. Interactive docking of the chromone-containing ligands into the HIV -1 protease receptor site, using the Ligandfit module, has indicated the importance of hydrogen-bonding interactions mediated by bridging water molecules situated in the receptor cavity. NMR spectroscopy has been used to elucidate complex and competing mechanistic pathways involved in the Baylis-Hillman reactions of selected 2-nitrobenzaldehydes with MVK in the presence of DABCO - reactions which afford the normal BaylisHillman product, the MVK dimer and syn- and anti-Baylis-Hillman type diadducts. The kinetic data confirm the concomitant operation of two pathways and reveal that, in the initial stage of the reaction, the product distribution is kinetically controlled, whereas in the latter stage, thermodynamic control results in the consumption of the normal Baylis-Hillman product and predominance of the anti-diadduct.
- Full Text:
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