Preparation, characterization and optimization of carbamazepine based pellets prepared by extrusion-spheronization technique
- Authors: Makoni, Kudzai Gabriella
- Date: 2020-04
- Subjects: Carbamazepine , Pharmacokinetics , Anticonvulsants , Drugs -- Controlled release , Drugs -- Dosage forms , Tablets (Medicine) , Drugs -- Administration , High performance liquid chromatography , International Conference on Harmonisation , Experimental design
- Language: English
- Type: Thesis , Masters , MSc (Pharmacy)
- Identifier: http://hdl.handle.net/10962/140478 , vital:37893
- Description: Carbamazepine (CBZ) is an oral antiepileptic drug (AED) that is prescribed as a first-line treatment for partial seizures. CBZ is a class II compound according to the Biopharmaceutical Classification System (BCS), hence it exhibits low aqueous solubility and high gastrointestinal tract (GIT) permeability...
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- Date Issued: 2020-04
Generalized linear models, with applications in fisheries research
- Authors: Sidumo, Bonelwa
- Date: 2018
- Subjects: Western mosquitofish , Analysis of variance , Fisheries Catch effort South Africa Sundays River (Eastern Cape) , Linear models (Statistics) , Multilevel models (Statistics) , Experimental design
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/61102 , vital:27975
- Description: Gambusia affinis (G. affinis) is an invasive fish species found in the Sundays River Valley of the Eastern Cape, South Africa, The relative abundance and population dynamics of G. affinis were quantified in five interconnected impoundments within the Sundays River Valley, This study utilised a G. affinis data set to demonstrate various, classical ANOVA models. Generalized linear models were used to standardize catch per unit effort (CPUE) estimates and to determine environmental variables which influenced the CPUE, Based on the generalized linear model results dam age, mean temperature, Oreochromis mossambicus abundance and Glossogobius callidus abundance had a significant effect on the G. affinis CPUE. The Albany Angling Association collected data during fishing tag and release events. These data were utilized to demonstrate repeated measures designs. Mixed-effects models provided a powerful and flexible tool for analyzing clustered data such as repeated measures data and nested data, lienee it has become tremendously popular as a framework for the analysis of bio-behavioral experiments. The results show that the mixed-effects methods proposed in this study are more efficient than those based on generalized linear models. These data were better modeled with mixed-effects models due to their flexibility in handling missing data.
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- Date Issued: 2018
Development of an antiretroviral solid dosage form using multivariate analysis
- Authors: Nqabeni, Luxolo
- Date: 2007
- Subjects: Analysis of variance , Experimental design , Multivariate analysis , Antiretroviral agents -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10145 , http://hdl.handle.net/10948/705 , Analysis of variance , Experimental design , Multivariate analysis , Antiretroviral agents -- South Africa
- Description: The aim of pharmaceutical development is to design a quality product and the manufacturing process to deliver the product in a reproducible manner. The development of a new and generic formulation is based on a large number of experiments. Statistics provides many tools for studying the conditions of formulations and processes and enables us to optimize the same while being able to minimize our experimentation. The purpose of this study was to apply experimental design methodology (DOE) and multivariate analysis to the development and optimization of tablet formulations containing 150 mg lamivudine manufactured by direct compression.
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- Date Issued: 2007