Foreign aid and the implementation of millennium development goals 4 and 5 in Nigeria
- Authors: Eyitayo, Adediran Foluke
- Date: 2019
- Subjects: Millennium Development Goals , Economic assistance -- Nigeria Maternal and infant welfare -- Nigeria Public health -- Nigeria Sustainable development -- Nigeria
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/39841 , vital:35479
- Description: Nigeria has the largest population in Africa and with approximately 160 million people. Nigeria has one of the largest populations of poor people in the world. Over the years, the rate of maternal and child mortality reduction in Nigeria has been slow and this is largely due to bad infrastructure, low quality of education and poor health sector. This is largely due to government bureaucracy, problems within the aid administration process and its influence on developmental issues. The Millennium Development Goals (MDGs) were created for countries to address human developmental issues within different countries around the world. The countries had to meet MDGs by 2015. Nigeria was not able to meet many of the set targets and had made only few improvements within the health department. This is largely due to government bureaucracy and the slow pace that is maintained during the formulation and implementation of governmental policies and programs. This study seeks to explore various issues that are identified in the attainment of MDGs 4 and 5: MDGs 4 with target 5 - 2/3 reductions in under than five mortality rates and MDG 5 with target 6 - ¾ reductions in the maternal mortality rate. This study will assess the efforts made by local and international organizations during the implementation of MDGs 4 and 5. This study will identify the impact of foreign aid on the health sector, with an intervention on the maternal and child mortality ratio, key international donors in the maternal and child sector. Document analysis is been adopted as the methodological approach for this research. These analysis focuses on documents such as publications, reports, policy papers and academic literature. One of the key findings in this study is that - lack of good policies of health services is a major barrier to the improvement in maternal and child mortality in Nigeria.
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- Date Issued: 2019
The role of women's agricultural cooperatives in meeting United Nations sustainable development goals
- Authors: Boni, Ntomboxolo
- Date: 2018
- Subjects: Millennium Development Goals , Agriculture, Cooperative -- South Africa , Cooperative societies -- South Africa , Women in agriculture -- South Africa , Rural development -- South Africa , Sustainable development -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/21768 , vital:29775
- Description: The majority of the people in South Africa were poor prior 1994, especially those in the rural areas. Poverty in the rural areas affected mostly the women. The government of South Africa designed support programmes to mainstream women into the economy, although it had its own challenges, such as the non-participation of women in their own development and the top-down approach that at times was used by the government in the implementation of the programmes. Owing to the nature of the rural areas, agriculture was identified as a sector that had a potential to improve the economy in order to address the challenges of unemployment, poverty and inequality. Since 2005 the concept of cooperative development has been a vehicle that has the potential to address the aforementioned challenges. In order for the cooperative development to run efficiently and effectively and in line with the cooperative principles and values, the government should keep the independence of this sector in mind by engaging the cooperatives in all the activities that were affecting the cooperative sector through their cooperative movement.The findings of the study showed that the agricultural cooperatives have not yet addressed poverty fully. All their members were employed and at times employment opportunities were extended to their community members, but the income earned was not satisfying its members. The women felt that they were not in control of their development as they lacked the capacity to lead and they were still led by the men in their cooperatives.
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- Date Issued: 2018
Synthesis and structure-activity relationship studies of 1,4-naphthoquinone derivatives as potential anti-trypanosomal agents
- Authors: Chakaingesu, Chikomborero
- Date: 2014
- Subjects: African trypanosomiasis , Trypanosoma brucei , Naphthoquinone , Protozoan diseases , Drugs -- Structure-activity relationships , Millennium Development Goals
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3873 , http://hdl.handle.net/10962/d1020959
- Description: Human African Trypanosomiasis (HAT) is an infectious, vector-borne protozoal disease which is amongst the so-called neglected diseases. In 2000, at a summit of the United Nations, eight Millennium Development Goals (MDGs) were set, to be achieved by 2015. MDG 6 states “to combat HIV/AIDS, malaria & other diseases”. With just under 2 years to go before the end of 2015, HAT is still thriving in developing countries. The drugs currently used for the treatment of HAT are in short supply, have severe side effects and those used to treat late stages of the disease are very difficult to administer. The aforementioned challenges call for research into this neglected disease in order to develop new, safe and easy-to-use medicines. Naphthoquinones are a class of compounds shown to possess anti-parasitic activity, amongst a variety of other biological activities, and therefore this pharmacophore was selected for this study. The purpose of this study was to synthesise derivatives of 2,3-dichloro-1,4- naphthoquinone to be tested for anti-trypanosomal activity and thereafter conduct structureactivity relationship studies. A series of reactions were carried out using thiophenol, phenol and aniline nucleophiles to synthesise thioether (-S-), ether (-O-) and amino (-NH-) derivatives of 2,3-dichloro-1,4-naphthoquinone with various halogen or methyl substituents. Purification of the products was carried out by recrystallisation. Nuclear magnetic resonance (NMR), infra-red (IR) and high pressure liquid chromatography coupled to an electro-spray ionisation mass spectrometer (HPLC-ESI-MS) were the analytical methods used for structural confirmation of the products. There were eighteen 1,4-naphthoquinone derivatives that were successfully synthesised using ethanolic solutions. Unfortunately, attempts to synthesise 1,4-naphthoquinones in reactions involving 2-(trifluoro-methyl)aniline and 2-isopropyl-5-methylphenol were unsuccessful, presumably due to steric hindrance by the bulky ortho-substituents. Although the aims of the synthetic procedures were to obtain both mono- and disubstituted products by nucleophilic displacement of the chlorine atom(s) of 2,3-dichloro-1,4- naphthoquinone, only monosubstituted products were obtained from substitution with aniline and phenol nucleophiles. Thiol nucleophiles, however, selectively yielded disubstituted products only. Synthesised naphthoquinone derivatives were tested against Trypanosoma brucei and calculation of the EC₅₀ values from the obtained dose-response curves was carried out using the four parametric equation. All the 1,4-naphthoquinones showed a degree of potency, except compounds 1b, 3c and 3e, which had little or lack of potency. Structure-activity relationship studies (SARs and QSARs) were carried out to determine which structural features or functional group substituents of the naphthoquinone derivatives contribute or take away from the desired anti-trypanosomal activity. It was found that compounds with the best in vitro anti-trypanosomal potencies in the series of analogous 1,4-naphthoquinone derivatives had EC₅₀ values in the range 2.137 to 2.884 μM. The most potent compound in the series was 2-chloro-3-(4-(trifluoromethyl)phenylamino)-1,4- naphthoquinone 1e; but it was 142-fold less potent than the reference standard of melarsoprol.
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- Date Issued: 2014