- Title
- The effect of tricyclic antidepressant drugs on the uptake and metabolism of serotonin by the pineal gland in organ culture
- Creator
- Pillay, Manoranjenni
- ThesisAdvisor
- Potgieter, Prof.
- Subject
- Antidepressants
- Subject
- Pineal gland -- Metabolsim
- Subject
- Serotonin
- Date
- 1983
- Date
- 2013-04-05
- Type
- Thesis
- Type
- Masters
- Type
- MSc
- Identifier
- vital:3828
- Identifier
- http://hdl.handle.net/10962/d1007053
- Identifier
- Antidepressants
- Identifier
- Pineal gland -- Metabolsim
- Identifier
- Serotonin
- Description
- The effect of tricyclic antidepressants (TADs) on a variety of pineal functions was assessed. TADs affected the uptake of ³H-5HT into bovine pineal slices within a particular concentration range of these drugs, DESI, CLOMI and IMI appeared to inhibit uptake slightly, within a limited concentration range. Surprisingly, DESI appeared to be a relatively potent 5HT uptake inhibitor. The 5-HT re-uptake system in the pineal probably differes from that in brain tissue. TADs had a marked effect on the metabolism of ³H-5HT in the rat pineal, in an organ culture system, MEL and N-acetylserotonin synthesis increased for the first 11 days and thereafter a slight decrease was observed. HTOH and HIAA also showed an initial increase followed by a slight decrease in synthesis. The synthesis of MTOH and MIAA was decreased. The possibility that TADs could affect HIOMT and SNAT synthesis and thereby change the metabolic pattern of 5-HT was investigated. TADs appeared to stimulate SNAT initially and thereafter a slight decrease from peak activity was observed. This is probably due to stimulation followed by development of subsensitivity of β-receptors, HIOMT activity also appeared to be affected by TADs. The existence of two types of HIOMT is suggested. There is a possibility that these changes in the metabolism of 5-HT could be implicated in the mechanism of action of TADs.
- Description
- KMBT_363
- Description
- Adobe Acrobat 9.53 Paper Capture Plug-in
- Format
- 231 p., pdf
- Publisher
- Rhodes University, Faculty of Pharmacy, Pharmacy
- Language
- English
- Rights
- Pillay, Manoranjenni
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