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The design, synthesis and antiplasmodial activity of a series of halogenated fosmidomycin analogues and hybrid drugs

  • Authors: Afolayan, Anthonia Folake
  • Date: 2012
  • Subjects: Uncatalogued
  • Language: English
  • Type: text , Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10962/64370 , vital:28538
  • Description: Malaria continues to be a devastating disease and a major cause of death in sub-Saharan Africa. With resistance against most of the available antimalarial drugs, there is a need for ongoing research and development of antimalarial agents. Fosmidomycin and its acetyl analogue FR900098 have been identified as potent inhibitors of Plasmodium falciparum, the causative agent of the most deadly form of malaria. Clinical trials of these agents have revealed poor absorption due to their high hydrophilicity. In the present studies the effect of halogenation of the acyl chain as well as the biological effect of extending the acyl sidechain was explored. This provided the basis on which fosmidomycin hybrids were designed to investigate the feasibility of hybrid extending into NADPH binding pocket. Synthesis of a series of halogenated FR900098 analogues was carried out in three stages. This included i) The introduction of the phosphonate group by reaction with 1,3dibromopropane in an Arbuzov reaction, ii) The introduction of a hydroxamate group by reaction of the propyl phosphonate by means of a nucleophilic substitution reaction with BocNHOBn and iii) The introduction of a halogenated acyl side chain on a protected fosmidomycin backbone. The synthesis of fosmidomycin-hybrids for which chloroquinefosmidomycin hybrids were used as the prototype, involved convergence of the two separately constructed moieties i.e. fosmidomycin and the quinoline moieties in a covalent linkage. The quinoline moiety was easily synthesized from the reaction of 4,7dichloroquinoline with 1,2-diamino ethane. The aminoquinoline so formed resulted in chloroquine-fosmidomycin hybrids 3.8 and 3.9 when reacted with halogenated FR900098 analogues. Antiplasmodial assays were conducted on the chloroquine-fosmidomycin hybrids and the halogenated fosmidomycin derivatives against the chloroquine resistant Gambian FCR-3 strain of P. falciparum. The most potent iodoacetyl fosmidomycin analogues 2.21 gave an IC50 value of 5.54 µM which is eight times more potent than the known antiplasmodial FR900098 which gave an IC50 value of 41.67 µM. All the halogenated FR900098 analogues showed better antiplasmodial activity than their non-halogenated derivatives. This indicated that the presence of halogens in the FR900098 analogues contributes to their biological Chapter 1 Literature review activity. The acetyl and propyl linked hybrids 3.8 and 3.9 showed potent antiplasmodial activity with IC50 values of 0.18 and 0.82 µM respectively. These were by far the most potent hybrids synthesized and provided leads for a new class of promising antimalarial agents. Preliminary E. coli DXR enzyme inhibition assays were carried out on the halogenated fosmidomycin analogues. The results showed good inhibition of the enzyme by the phosphonic acids of the chloroacetyl and chloropropyl analogues 2.1 and 2.2 respectively. Molecular modelling of the compounds on E. coli (PDB code: 2EGH) and P. falciparum (PDB code: 3AUA) DXR showed strong binding of the halogenated fosmidomycin analogues while the hybrids in the absence of docked NADPH showed minimum binding to the enzymes.
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  • Date Issued: 2012

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An analysis of the influence of domestic macroeconomic variables on the performance of the South African stock market sectoral indices

  • Authors: Hancocks, Ryan Lee
  • Date: 2011
  • Subjects: Johannesburg Stock Exchange , Stock price indexes -- South Africa , Interest rates -- South Africa , Macroeconomics -- Econometric models
  • Language: English
  • Type: text , Thesis , Masters , MCom
  • Identifier: vital:954
  • Description: An econometric study was undertaken to determine the extent to which selected macroeconomic variables influenced stock market prices on the All-Share, Financial, Mining and Retail Indices of the Johannesburg Stock Exchange in South Africa from 1996:7 to 2008:12. The Johansen cointegration method was used to determine whether cointegrating relationships existed between the macroeconomic variables and the stock market indices. A Vector Error Correction model was estimated and found significant results that money supply, inflation, long and short- run interest rates, and the exchange rate all had an influence on stock market prices. Further, the VECM results for each sector indicated that certain macroeconomic variables had differing influences on each sector of the stock market. Impulse Response tests indicated that the selected macroeconomic variables caused shock to the sectoral indices in the short-run but that the effect was lagged. The Variance Decomposition tests conducted supported earlier evidence that the macroeconomic variables had a strong level of sectoral index determinacy in the long run. The results found that the All-Share and Financial Indices were negatively influenced by inflation and short term interest rates in the long run, while the Financial Index also had a negative relationship with long-run interest rates. Money supply was found to have a positive effect on all the indices. A weakening of the exchange rate was found to have a positive influence on both the Retail and Mining Indices, while it negatively affected the All-Share and Financial Indices. The long-run interest rate had a positive influence on both the Retail and Mining Indices. Overall the study finds that macroeconomic variables are important determinants of stock market prices in South Africa and that it is important to examine each sector of the stock market separately to capture what are different effects. The limitations of the study are that a different measure for exchange rates from the nominal rand/dollar exchange rate used here may yield more decisive results and provide insight into the link between exchange rate behaviour and performance of especially the retail sector.
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  • Date Issued: 2011

An investigation into international transfer pricing guidelines and the anomalies arising from business restructurings by multi-national enterprises

  • Authors: Stelloh, Marcus Matthias
  • Date: 2011
  • Language: English
  • Type: text , Thesis , Masters , MCom
  • Identifier: vital:879 , http://hdl.handle.net/10962/d1001633
  • Description: The number of multinational enterprises has increased substantially. In part due to the integration of national economies (the European Union), improvements in communication and technology and the opportunity to reduce costs as a result of globalisation. Transfer pricing and especially business restructuring within multinationals is a fairly new concept.Professional legal and audit firms have different views on how to approach business restructurings. This research analyses important transfer pricing aspects and the anomalies that arise through business restructurings. The research method used in this research paper is primarily qualitative, comprising the analysis of various documentary sources of data. Relevant South African and international case law, tax legislation, the OECD Transfer Pricing Guidelines for Multinational Enterprises and Tax Administrations, the Transfer Pricing Aspects of Business Restructurings Discussion Draft and other reports were consulted and analysed. Further the views of recognised legal and tax experts that have been published in technical journals and text books were also considered and examined. A hypothetical example of a business restructuring transaction was constructed in order to illustrate practical issues and different approaches to solving them. The research has argued that the arm’s length principle, which forms the bases of transfer pricing regulation, is not an exact science but theoretically it is the most suitable measure.It may not be able to incorporate all variables, such as the cost savings through synergies of multinational enterprises, but it promotes international trade and investment by ensuring that transactions are based on fair prices. Business restructurings create anomalies in applying the arm’s length principle but these anomalies can be dealt with within the regulatory structure. The business restructuring approach recommended is realistic and pragmatic, but more clarity may be needed in certain circumstances. The research has also discussed the avoidance of transfer pricing audits, including having appropriate transfer pricing policies and documentation.
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  • Date Issued: 2011

Extending legal professional privilege to non-legal tax practitioners in South Africa: a comparative and constitutional perspective

  • Authors: Jani, Pride
  • Date: 2011
  • Language: English
  • Type: text , Thesis , Masters , MCom
  • Identifier: vital:882 , http://hdl.handle.net/10962/d1001636
  • Description: This study explains the differing rights of taxpayers, based on the nature of the profession of the tax adviser they consult. Those who utilize the services of tax attorneys can rely on the protection afforded by legal professional privilege whereas those who obtain their advice from non-legal advisers, such as accountants and other tax advisers, cannot claim the same protection. Legal professional privilege is a substantive right which should be extended to cover clients of non-legal tax advisers. The continued denial of the privilege to clients of nonlegal tax practitioners while it is availed to those who approach legal practitioners infringes the rights to privacy and equality contained in the South African Constitution. The object of this research is to show that the common law concept of legal professional privilege is amenable to extension so as to cover the clients of non-legal tax advisers. A qualitative approach was adopted which involved an in-depth analysis of the origins, rationale as well as the requirements for the operation of the doctrine. This also involved a constitutional as well as a comparative dimension. The constitutional dimension sought to show that the current distinction is untenable under the South African Constitution by virtue of the infringement of the rights to privacy and equality. The comparative dimension presented an analysis of the various jurisdictions that have extended the doctrine as well as those that are still to do so or have adamantly rejected the idea. The differential treatment of taxpayers based on the professional they engage contravenes the privacy and equality provisions and is thus unconstitutional. The study demonstrates that legal professional privilege is amenable to extension and there is need for legislative intervention as the courts are limited in the extent to which they may intervene in light of the separation of powers and judicial deference. Legal professional privilege should therefore be extended to protect the clients of non-legal tax advisers as opposed to partial protection which subsists at the moment.
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  • Date Issued: 2011

Intellectualisation of African languages with particular reference to isiXhosa

  • Authors: Maseko, Pamela
  • Date: 2011
  • Subjects: Xhosa language -- Study and teaching -- South Africa , Language and education -- South Africa , African languages
  • Language: English
  • Type: text , Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10962/58035 , vital:27035
  • Description: The research explores the relationship between language and education, and motivates for the intellectualisation of African languages, isiXhosa in particular, and for their use in education. The main rationale behind this is that access to, and success in education can largely be realised if that education is mediated in one’s first language. The thesis discusses works of prominent scholars who have written on the subject - relating cognitive abilities and achievement in education to language in which that education is offered. The lack of terminology in new domains in African languages as barrier to mother tongue education is laid bare by looking specifically at the history of intellectualisation of isiXhosa, from the missionaries in the 1820s up to the new endeavours as recently as 2008. Terminologies that were developed during the Bantu Education era, where development of isiXhosa and other indigenous African languages was accelerated in order to respond to the demands of moedertaal-onderwys (mother tongue education) are surveyed, and the process of their development analysed. Three main terminology lists developed during this period are analysed against terminology development principles, approaches and methods that are seen as a measure to ensure quality terminology development. The efforts of the development of isiXhosa during the post-apartheid South Africa, especially the government-driven initiatives, are also critiqued even though these are not as effective and as extensive, especially in education. The result of this analysis is that African languages and isiXhosa in particular, can be used in scientific disciplines and at the highest levels of education. Its grammar is advanced, and its lexicon is extensive such that new concepts that need to be named can be named, using appropriate term creation strategies. There are also technological tools such as WordSmith tools that can be used that can advance its development, ensuring that the concept represented in the newly-created term is precise, concise and appropriate in terms of its discipline. Therefore it is argued that, in the interim, terminologies should be developed, in various subjects, to support learning, which at this stage is mediated in English, for those students who have other languages as mother tongue. Those terminologies that have been developed in the various historical periods should be collated, revised and brought into the classrooms. The thesis argues that real intellectualisation of isiXhosa and other African languages rests on the use of these languages in classrooms and lecture halls, and in the value that all role players place on these languages.
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  • Date Issued: 2011

Seductive Manoeuvres: an analysis of the use of feminist performance strategies as a means of staging alternative sexualities in two dance theatre works

  • Authors: Barnard, Joni
  • Date: 2011
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10962/76823 , vital:30627
  • Description: Located within the discipline of Performance Studies, this thesis seeks to validate performance and theatre, specifically dance theatre, as legitimate fields of research and enquiry that can enrich the polemics surrounding discourse, representation, the body and identity. Within this thesis I explore and analyse the creative processes and performance strategies used in two dance theatres works: Acty Tang’s Chaste (2007) and my own work entitled Displayed and Framed (2008) and how these strategies support the staging of alternative sexualities. I argue that the staging of alternative sexualities calls for an alternative approach to the performance strategies utilised in the production of space, the representations of the body and the use of text in both works. Each work offers a particular exploration of gender and sexuality in the attempt to represent alternative identities, alternative bodies and alternative sexualities. In this thesis I identify the endeavour to stage ‘otherness’ as a feminist endeavour and thus identify the performance strategies utilised in each work as feminist performance strategies. Through my analysis I wish to highlight the ways in which a feminist approach can contribute to and enrich both the staging of and understanding of alternative sexualities. In both Chaste (2007) and Displayed and Framed (2008), the choreographers of each work are also performers in their own work in an endeavour to explore and represent their own identity. The analysis of my own work requires that I play the multiple roles of choreographer, performer and researcher. In this analysis I provide accounts of my own experiences, processes and struggles of creating Displayed and Framed (2008) which are analysed in conjunction with my readings of Chaste (2007) and Tang’s personal experiences in creating the work. Thus this thesis explores the value of reflection and self reflectivity in the processes of creating performance.
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  • Date Issued: 2011

The contribution made by Mr Justice EF Watermeyer to South African tax jurisprudence

  • Authors: Thackwell, Robert Colin
  • Date: 2011
  • Language: English
  • Type: text , Thesis , Masters , MCom
  • Identifier: vital:881 , http://hdl.handle.net/10962/d1001635
  • Description: The objective of this thesis is to highlight the colossal contributions made by the late Justice Watermeyer to South African tax jurisprudence. His contributions are viewed from a practical application point of view as well as from a statutory interpretative perspective. The style and technique with which he delivered his judgments are also considered to be a contribution in their own right. The core of this thesis is the analysis of seven of Justice Watermeyer‟s most influential judgments. The development and application of the principle or principles developed in each of these seven judgments is then traced chronologically through case law up until recent judgments. It is most notable that each and every phrase contained in section 11(a) of the Income Tax Act has been interpreted by Justice Watermeyer. These interpretations are still viewed as correct statements of the applicable law and will continue to be referred to on a regular basis given the fact that section 11(a) is one of the most widely contested provisions in the Income Tax Act. Several references to his approach to statutory interpretation are made through the course of the case analyses. Whilst significant evidence of a purposive oriented approach to interpretation appears in some judgments, such evidence is lacking in others. An absolute or conclusive submission in terms of his approach to statutory interpretation is not sufficiently supported. His style of judgment is also referred to and commented on, with particular focus placed on his use of illustrative examples. The contribution to South African tax law by Justice Watermeyer is found to be nothing short of enormous. He was and continues to be influential with respect to section 11(a),the definition of gross income in section 1, common law principles of tax avoidance as well as the interpretation of statutory laws of tax avoidance. It is anticipated that some of his interpretations with respect to statutory rules of tax avoidance will be referred to when the relatively new anti-avoidance provisions become the subject of litigation.
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  • Date Issued: 2011

The disempowering faces of the flexible firm: a case study of Gaborone Private Hospital

  • Authors: Makorie, Theona Tariro
  • Date: 2011
  • Subjects: Gaberone Private Hospital -- Employees , Gaberone Private Hospital -- Personnel management , Gaberone Private Hospital -- Management , Nursing services -- Administration , Nurses -- Employment -- Botswana , Nursing -- Law and legislation -- Botswana , Hospitals -- Medical staff -- Botswana , Hospitals -- Administration -- Botswana
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: vital:3352
  • Description: The purpose of the study was to investigate the ways in which the practice of t the Flexible Firm Model (FFM) disempowered the non-citizen professional nurses at Gaborone Private Hospital (GPH) in Gaborone, Botswana. GPH is a member of the Life Health care group of private hospitals based in South Africa. This study sought to probe the manner in which the practice of FFM influenced the employment relationship for non-citizen professional nurses. It also sought to examine the impact of the nature of the employment relationship on career development and representation and participation. Both qualitative and quantitative research methodologies were applied. Questionnaires were used to collect quantitative data. Thirty-five questionnaires were issued out to professional nursing staff and thirty-three responses were received. The response rate was ninety-four percent. The qualitative research data consisted of twelve in-depth interviews with professional nurses, the human resources manager , a professional nurse agency owner and a private clinic co-owner. Document analysis in the form of labour legislation, employee guides and employment contracts was used to validate data collected from the in-depth interviews. The results from the questionnaire revealed that an overwhelming majority of the professional nurses were Non-Citizens' dependent contractors. Although just under half of the participants held two or more previous contracts with GPH, an overwhelming majority had never been promoted. In addition, none of the participants were affiliated to the Botswana Nurses Association (BNA), the local equivalency of a professional nursing trade union. The in-depth interviews disclosed a sense of helplessness at their perceived disempowerment within the employment relationship, a poor career development and weak representation and participation. This study concluded that disempowerment at GPH was manifested through worker representation and participation and in effective skill upgrade. These forms of disempowerment were made worse by the global professional nurse shortage and maladministration of avail able human resources. Effective use of human resources and continued education could be employed to circumvent the adverse results of disempowerment.
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  • Date Issued: 2011

The relationship between leadership style and employee engagement in Sasol Gas, South Africa

  • Authors: Duma, Thobile
  • Date: 2010
  • Language: English
  • Type: text , Thesis , Masters , MBA
  • Identifier: http://hdl.handle.net/10962/64034 , vital:28524
  • Description: The main purpose of this study was to determine whether there is a significant relationship between leadership styles of Sasol Gas leaders and their followers’ level of employee engagement. The instruments used in the study were the Multifactor Leadership Questionnaire (MLQ) (Form 5X) and the Utrecht Work Engagement Scale (UWES 9). The MLQ (5X) was completed by the followers and leaders of Sasol Gas to determine whether Sasol Gas leaders use transactional, transformational and/or laissez-faire leadership styles. The work engagement instrument was completed by each follower to determine current levels of employee engagement. Descriptive statistics were obtained and correlations completed for the data to determine whether the different leadership styles exhibit different levels of engagement. The MLQ survey results indicate that leaders of Sasol Gas have more transformational than transactional leadership styles. The UWES 9 measured the three factors of vigour, dedication, and absorption; dedication had the highest mean compared to vigour and absorption, indicating that Sasol Gas employees strongly identify themselves with their work because it is experienced as meaningful, inspiring, and challenging. This research found a statistically significant, albeit weak, relationship between transformational and transactional leadership styles and employee engagement. This is a positive reflection of the current Sasol Gas leaders because empirical evidence shows that transformational leadership behaviours are more successful for attaining and fulfilling goals during organisational change.
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  • Date Issued: 2010

Discourses around abortion in a low-income community in the Western Cape

  • Authors: Bowes, Tanya-Ann
  • Date: 2009
  • Subjects: Abortion -- Moral and ethical aspects , Abortion -- Religious aspects -- Christianity , Patriarchy -- South Africa , Abortion -- South Africa -- Western Cape , Male domination (Social structure)
  • Language: English
  • Type: text , Thesis , Masters , MSocSci
  • Identifier: vital:2939 , http://hdl.handle.net/10962/d1002448
  • Description: Since the introduction of the Choice on Termination of Pregnancy Act in 1996, research concerning abortion has primarily focused on public health issues or on the personal experience of women. The cultural and social context within which women experience a termination of pregnancy and in which services are offered has received less attention. The purpose of this study was to analyse public discourses around abortion in a low-income community in the Western Cape. Focus groups were used to gather data from three women’s and three men’s groups. The findings suggest that the agenda of pro-life discourses in this community is not always to defend the life of the fetus. Rather these discourses serve to protect, preserve and maintain the power of the traditional nuclear family, headed by the husband, over women’s reproduction and sexuality. Religious and moral arguments serve to disguise the gender issues at stake. However, instances also occurred where TOP was supported if the husband participated in the decision-making process. Therefore, his presence normalised abortion. Thus, the prevailing public discourses around abortion in this community either support or negate abortion in order to further the agenda of patriarchy.
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  • Date Issued: 2009

Exploring job search and the causes of endogenous unemployment: evidence from Duncan Village, South Africa

  • Authors: Duff, Patrick Alexander
  • Date: 2009
  • Subjects: Unemployment , Unemployment -- Social aspects -- South Africa -- East London -- Duncan Village , Job hunting -- South Africa -- East London -- Duncan Village , Labor market -- South Africa
  • Language: English
  • Type: text , Thesis , Masters , MCom
  • Identifier: vital:1026
  • Description: Despite high rates of unemployment in South Africa, there is little consensus about its origins and solutions to the problem. Job search (how and when people search for work)is one aspect of the unemployment problem. Job search is shown to be a complex process strongly linked to the endogenous structure of the labour market. The flaws in traditional methods (theoretical and measurement) highlight this. Using data from a tailor-made survey in Duncan Village (a peri-urban area in Buffalo City, South Africa) the research examines factors that influence the effectiveness of job search. The results show that mode of search (how people look for work) is used as a signal by employers. Degrees of success are stratified amongst searchers using either ‘word of mouth’, place-to-place or formal modes of search. The thesis provides a method-test to reveal a complex body of evidence that has yet to be fully explored by practitioners in this field.
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  • Date Issued: 2009

Human-river relationships in the Kat River catchment and the implications for integrated water resource management (IWRM) : an exploraratory study

  • Authors: Birkholz, Sharon Alice
  • Date: 2009
  • Subjects: Aquatic ecology -- South Africa -- Kat River , Rivers -- South Africa -- Kat River -- Sociological aspects , Rivers -- South Africa -- Kat River , Water supply -- South Africa -- Kat River -- Management , Human ecology -- South Africa -- Kat River , Stream ecology -- South Africa -- Kat River
  • Language: English
  • Type: text , Thesis , Masters , MSc
  • Identifier: vital:4838 , http://hdl.handle.net/10962/d1005514
  • Description: Through out this study ‘relational scenarios’ were seen as the possible outcomes of the expression of human-river relationships in a catchment. Working within Inglis’s (2008, pg. 10) comment that ‘the Human World Relationship is expressed through a person’s views and behaviour towards the natural world, which can be either constructive or destructive’, two relational scenarios were selected to represent these two predicted outcomes of human-environment (or in the case of this thesis human-river) relationships: IWRM, seen as constructive and mutually beneficial to both the social and ecological system, and the Tragedy of the Commons, seen as destructive and parasitic in nature. In respect to this assertion, a conceptual framework or model was developed and used to guide the inductive process of this research. Through a social survey (administered via semi-structured interviews) of stakeholders (water-users) in the Kat River Catchment, Eastern Cape, South Africa, social attitudes towards the Kat River were explored. These attitudes were considered as variables that relate to the expression of ‘Human World Relationships’ namely ‘values and behaviour’ (Inglis, 2008, pg. 10). The findings of this thesis confirm that attitudes are influential components of human-river relationships in the Kat River Catchment. It was observed from the findings that the attitudes individuals have towards the Kat River have the potential to influence the ways people interact with the River and its associated resources, and are in turn influenced by the condition of the River and connections people have or make with the River within their daily lives. Such relationships in turn affect the management of the River and its water resources and influence how individuals approach water-related issues and undertake the associated activities. Given this understanding it was then proposed that attitudes could provide information that enables the prediction of likely ‘relational scenarios’ (IWRM or the Tragedy of the Commons) in a catchment. The findings appear to support this proposal, and three main attitude groups (utilitarian, associative and dissociative) were identified and used to further the discussion into how this knowledge could be used in predicting possible relational scenarios based on human-river relationships. Further exploration of the identified attitude groups suggested that these variables are significantly influenced by environmental ethics and place attachment (present in the community) and a series of guiding frameworks were developed to facilitate the exploration of the attitude groups relative to these concepts. The frameworks were generated from the hypothesis that knowledge of attitude groups in a catchment, in connection with the relative degrees to which moral values and worldviews are expressed, could provide insight into the readiness of a catchment system for the implementation of IWRM and/or the facilitative steps needed to shift the influence of unfavourable attitude groups (i.e. dissociative attitudes). Such steps would most likely involve extensive educational, awareness and capacity building programs. Finally, given the above theoretical frameworks, inductively developed from the findings of the social survey and related literature, the conceptual model was reevaluated and extended to include the thesis findings and hypotheses. It is suggested that in a catchment where there is a balance between the expression of utilitarian and associative attitude groups, then there is a high probability of finding present evidence of mutually beneficial human-river relationships already in play, as well as ‘fertile soil’ for the promotion of IWRM and philosophies and skills that generate such relationships. Alternatively in an area with a strong expression of dissociative attitudes, it is more likely to find evidence of destructive, more parasitic-like relationships being expressed, and a lack of commitment and interest in being involved in changing the status quo. It is likely that where both associative and dissociative attitudes are present there will be an overlap of elements of both scenarios – a situation that is probable in most catchments – depending on the strength of expression of either attitude group the balance will shift (be shifting) between the two relational scenarios.
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  • Date Issued: 2009

Myth, Music & Modernism: the Wagnerian dimension in Virginia Woolf's Mrs Dalloway and the waves and James Joyce’s Finnegans Wake

  • Authors: McGregor, Jamie Alexander
  • Date: 2009
  • Language: English
  • Type: text , Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10962/77069 , vital:30662
  • Description: The study of Wagner's influence on the modernist novel is an established field with clear room for further contributions. Very little of the criticism undertaken to date takes full cognizance of the philosophical content of Wagner's dramas: a revolutionary form of romanticism that calls into question the very nature of the world, its most radical component being Schopenhauer's version of transcendental idealism. The compatibility of this doctrine with Wagner's earlier work, with its already marked privileging of myth over history, enabled his later dramas, consciously influenced by Schopenhauer, to crown a body of work greater than the sum of its parts. In works by Virginia Woolf and James Joyce, the "translation" of Wagnerian ideas into novelistic form demonstrates how they might be applied in "real life". In Mrs Dalloway, the figure of Septimus can be read as partly modelled on Wagner's heroes Siegfried and Tristan, two outstanding examples of the opposing heroic types found throughout his oeuvre, whose contrasting attributes are fused in Septimus's bipolar personality. The Wagnerian pattern also throws light on Septimus's transcendental "relationship" with a woman he does not even know, and on the implied noumenal identity of seemingly isolated individuals. In The Waves, the allusions to both Parsifal and the Ring need to be reconsidered in light of the fact that these works' heroes are all but identical (a fact overlooked in previous criticism); as Wagner's solar hero par excellence, Siegfried is central to the novel's cyclical symbolism. The Waves also revisits the question of identity but in a more cosmic context – the metaphysical unity of everything. In Finnegans Wake, the symbolism of the cosmic cycle is again related to the Ring, as are Wagner's two heroic types to the Shem / Shaun opposition (the Joyce / Woolf parallels here have also been overlooked in criticism to date). All three texts reveal a fascination with the two contrasting faces of a Wagnerian hero who embodies the dual nature of reality, mirroring in himself the eternal rise and fall of world history and, beyond them, the timeless stasis of myth.
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  • Date Issued: 2009

Primary caregivers' experience of raising children with autism: a phenomenological perspective

  • Authors: Swanepoel, Yolandi
  • Date: 2005
  • Subjects: Autism in children Autistic children Autism in children -- Diagnosis Parents of autistic children
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: vital:3067 , http://hdl.handle.net/10962/d1002576
  • Description: Autism occupies an extreme position among childhood pathologies due to its severity, duration and impact on the family. In this qualitative study, four primary caregivers of autistic children were interviewed regarding their experiences of the diagnostic process, their post-diagnostic adjustment, and how helping professionals can improve their service rendering to these families. This study utilised a phenomenological approach to look at primary caregivers as the best-informed authority to explore and describe their lived realities and experiences of raising their autistic children in South Africa. The rationale for a phenomenological approach in this study is that such an interpretative inquiry enables material to be collected and analysed within the specific context of the subjective realities of primary caregivers of autistic children in South Africa. The researcher utilised semi-structured, in-depth, face-to-face interviews as method of data collection. Each participant was interviewed over the course of three separate interviews. The themes and categories that resulted from a content analysis of the material were grouped into two broad fields of experience, namely: (1) experiences surrounding the diagnostic process; and (2) the pervasive influence of autism on different areas of family life. In terms of experiences surrounding children’s diagnosis, four themes were identified: (1) Being a new parent and making sense out of chaos; (2) Responsibility and blame; (3) Confusion and disillusionment during early experiences with helping professionals; and (4) Feelings about the diagnosis. The pervasive influence of autism on different areas of family life includes: (5) Strained family relationships; (6) Challenges of behaviour management and disciplining the autistic child; (7) Challenges of finding suitable resources for education and day-care; and (8) Maintaining the family unit and doing things as a family.
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  • Date Issued: 2005

Interactivity in online journalism: a case study of the interactive nature of Nigeria's online Guardian

  • Authors: Folayan, Oluseyi Olukemi
  • Date: 2004
  • Subjects: Guardian (Nigeria) Online journalism Electronic publishing -- Nigeria Electronic newspapers -- Nigeria Electronic news gathering -- Nigeria Nigeria -- Newspapers
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: vital:3429 , http://hdl.handle.net/10962/d1002883
  • Description: Interactivity is a distinguishing feature of the online environment but online newspapers have been slow in recognising interactivity as an essential condition of effective Web communication. Existing research show online newspapers generally offer few and token interactive options. This research explored interactivity in online journalism using Nigeria's online Guardian as a case study exploring the nature, levels and utilisation of interactivity and interactive features on the site. This study found that few interactive options are offered in Nigeria's online Guardian and those interactive options on offer just produced an illusion of interactivity; it was apparent that little effort was made to give interactive options on the site the significant attention they deserve. The study highlighted the difference between the availability and use of interactive features on an online newspaper site: the mere presence of such features does not necessarily speak to the levels or nature of interactivity on the site. The difficulty in obtaining findings for the qualitative aspect of this study spoke significantly to the findings in light of the fact that these were attempts using interactive options provided by the newspaper site. They stress what relevant literature highlights: the mere presence of interactive features is not in itself interactivity . Factors contributing to the low levels of interactivity in Nigeria's online Guardian include lack of technical expertise plus human and financial resources and the persistence of a mindset that hinders the development and integration of new information communication technologies and interactivity in online journalism. Theoretically, the possibilities are vast but the likelihood of translating theory into reality appears slim. For Nigeria's online Guardian to become interactive in a participatory way, it must undergo changes and choices about values, goals and standards. There must be a shift in attitudes and approaches towards news-content production and delivery as well as the problematic commercial aspects of electronic publishing routines and the effect of such choices on management and newsroom organisation.
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  • Date Issued: 2004

A study of the powers of the Swazi monarch in terms of Swazi law and custom past, present and the future

  • Authors: Khoza, Phumlile Tina
  • Date: 2003
  • Subjects: Kinship -- Africa Swazi (African people) -- Social life and customs Customary law -- Swaziland Constitutional law -- Swaziland Swaziland -- Politics and government
  • Language: English
  • Type: text , Thesis , Masters , LLM
  • Identifier: vital:3702 , http://hdl.handle.net/10962/d1004723
  • Description: The thesis covers the branches of law known as Constitutional law and Customary law. It focuses on the powers of the Swazi monarch, which are based on a combination of the received Western law and Swazi custom. For the purposes of this study, therefore, Swazi law and custom shall be taken to include both the statutory law and the yet unwritten customary law. Swaziland is black Africa's only remaining traditional monarchy, ruled as it is by the Ngwenyama, an indigenous institution, whose origin is derived from custom. The resilience of this ancient system of government in a continent where modernisation and constitutional democracy among other factors have led to its extinction is phenomenal, particularly because some commentators have described traditionalism in modern Africa as an "embarrassing anachronism.' In Swaziland the monarchy continues to be a vibrant system and the nation is currently engaged in a process of not only codifying the customary law but also of drafting the constitution of the country. One of the key areas of concern is the question of the distribution of power between the monarch and the people under the proposed constitution. Traditionalists are of the view that the powers that the King currently exercises should remain intact as they are a reflection of the Swazi law and custom. Progressives, on the other hand, are of the view that the current position makes the King an absolute monarch and are thus proposing a change from an absolute to a constitutional monarch. In other words they want some kind of checks and balances in the envisaged system of government. The study will show that the constitutional evolution of Swaziland and the exigencies of synthesising modern and traditional systems of governance have over the years obscured the true nature of the powers of the monarch in terms of Swazi custom. Thus before we can consider whether the future of the monarchy in Swaziland depends on the harmonisation of modern and traditional systems of governance, it is necessary to revisit the past to determine the powers of the monarch in their embryonic form, for it is from this period that we can extrapolate the powers of the Ngwenyama in terms of Swazi custom. The thesis has been arranged as follows: The first chapter will review the precolonial political system of Swaziland with a view to establishing whether monarchical authority was founded on command or consensus. The various theories, which seek to explain the foundations of the monarchical system of government, will be outlined. The second chapter will focus on European influence on the Swazi traditional system of government. The third chapter will be an analysis of the powers of the monarch under the 1968 independence constitution. The fourth chapter will focus on the effect of the repeal of the 1968 independence constitution by the Monarch. The fifth chapter will focus on the constitutional reforms under the reign of king Mswati III. The sixth and last chapter focus on proposals for reform. The research method used was in the main, an analysis of relevant legal principles as contained in textbooks, legislation, journals, the scant case law that is available in this area of the law and other relevant materials. A comparative survey of ancient African kingdoms will be done, with emphasis on those Kingdoms, which later became British colonial possessions. It is hoped that this comparative analysis will help explain the evolution of these traditional structures alongside modern governmental institutions.
  • Full Text:
  • Date Issued: 2003

A portfolio of original compositions with a commentary

  • Authors: Nkuna, Musa
  • Date: 2000
  • Subjects: String quartets -- Scores Song cycles -- Scores Music -- Africa -- Scores
  • Language: English
  • Type: text , Thesis , Masters , MMus
  • Identifier: vital:2698 , http://hdl.handle.net/10962/d1018689
  • Description: This portfolio consists of four diverse original compositions written in 1999 : a string quartet, a cello suite and a set of two choral pieces.
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  • Date Issued: 2000

"Making the News": a case study of East Cape News (ECN)

  • Authors: Davidow, Audrey Beth
  • Date: 1999
  • Subjects: Reporters and reporting Reporters and reporting -- South Africa Attribution of news News agencies -- South Africa -- Eastern Cape
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: vital:3424 , http://hdl.handle.net/10962/d1002877
  • Description: To fully comprehend the complex process of news making, we must first understand that the events we read about everyday in the newspaper are not merely a reflection of the world in which we live. News does not just happen. Rather, it is a socially constructed product in which events are “made to mean” (Hall, 1978). Thus, the news plays a fundamental role in shaping our interpretations of reality - our perceptions of the world as we know it. Informed by a structuralist approach to news making, this research provides a detailed ethnographic study of the determinants that shape and produce news in the South African print media. I provide examples of the influence various factors, operating at all levels, exert within the news making process. The research focuses on the news production process at East Cape News Pty. Ltd. (ECN) a small news agency operating in the peripheral news region of South Africa’s Eastern Cape. It considers the journalistic routines and interests of the ECN reporters; how these reporters select events and turn them into news, how they interpret their significance and how they formulate them as news stories. The research also considers the second stage of selection ECN news must pass before it is read by the public - the “gates” of external newspapers. In this section, the study is primarily concerned with which ECN news stories succeed past the gates of national newspapers as these are the newpapers that play an influential role in shaping national perceptions of the marginalised Eastern Cape region. A province burdened with devastating rural poverty, unstable government, and little economic growth, the Eastern Cape warrants little coverage from the national, Johannesburg-based news market. As a result, little news of the Eastern Cape is published nationally, further perpetuating the region’s perceived insignificance on a national level. This point also demonstrates the fact that news both shapes, and is shaped by, our ideologies. News, therefore is ideological (Fishman, 1977). My findings reinforce many of the observations of other media researchers informed by a structuralist approach in the field of news making. However, some elements of news making emerge which appear to be unique in terms of other studies of news making. These elements are primarily a result of ECN’s informal organisational structures which allow the journalists a greater level of autonomy than a larger more bureaucratic organisation might. Thus, in addition to considering the structures that shape the news, I also discuss the role of human agency in making the news.
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  • Date Issued: 1999

The effects of night work and task diversification on efficiency of performance

  • Authors: Munton, Lynne Kerry
  • Date: 1998
  • Subjects: Night work -- Evaluation , Shift systems , Performance
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: vital:5175 , http://hdl.handle.net/10962/d1018253
  • Description: This study investigated the effects of night work on performance efficiency. Night work is generally acknowledged to impair performance, yet much research has contradicted this assertion. The feasibility of including brief periods of physical activity to stimulate arousal within mentally demanding work shifts was also evaluated. Thirty six postgraduate volunteers were assigned to either the cognitive tasks (CT) or cognitive and motor tasks (CMT) group. All subjects performed three psycho-motor tests, using the Vienna Test System, at midday and midnight. The CMT group performed a short cycling activity before each test. Heart rate responses served as physiological measures, the Perceived Strain Scale was used to quantify individual perceptions of strain and performance efficiency was assessed in terms of speed and accuracy. Although several trends were apparent, no significant differences (p < 0.05) were revealed with respect to the three performance variables between the midday and midnight test sessions, or between the CT and CMT subjects, other than the higher heart rates recorded in the CMT group. In summary, neither time of day nor physical activity were found to affect performance within the controlled environment of this study.
  • Full Text:
  • Date Issued: 1998
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