"Our Voice of Africa": it is less than our voice without a woman's voice
- Authors: Tumusiime, Amanda
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/145687 , vital:38458 , https://0-muse.jhu.edu.wam.seals.ac.za/article/695397/pdf
- Description: In her poem Our Voice (Chipasula and Chipasula 1995: 166–67) Noémia de Sousa (1926–2002) speaks about “our voice of Africa” as that voice that is liberative; that voice which opens “up new ways” and “lights up remorse … and burns glimmers of hope in the dark souls of desperate people” who cry out for emancipation from “slavery.” That voice which creates new possibilities by awakening a “cyclone of knowledge.” That voice which can persistently and effectively represent the aspirations of “millions of voices that shout, shout and shout!” for freedom and self-actualization.
- Full Text:
- Date Issued: 2018
- Authors: Tumusiime, Amanda
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/145687 , vital:38458 , https://0-muse.jhu.edu.wam.seals.ac.za/article/695397/pdf
- Description: In her poem Our Voice (Chipasula and Chipasula 1995: 166–67) Noémia de Sousa (1926–2002) speaks about “our voice of Africa” as that voice that is liberative; that voice which opens “up new ways” and “lights up remorse … and burns glimmers of hope in the dark souls of desperate people” who cry out for emancipation from “slavery.” That voice which creates new possibilities by awakening a “cyclone of knowledge.” That voice which can persistently and effectively represent the aspirations of “millions of voices that shout, shout and shout!” for freedom and self-actualization.
- Full Text:
- Date Issued: 2018
'We pledge to improve the health of our entire community'
- Grant, Carolyn, Nawal, Dipty, Guntur, Sai Mala, Kumar, Manish, Chaudhuri, Indrajit, Galavotti, Christine, Mahapatra, Tanmay, Ranjan, Kunal, Kumar, Gangesh, Mohanty, Sunil, Alam, Mohammed Aftab, Das, Aritra, Jiwani, Safia
- Authors: Grant, Carolyn , Nawal, Dipty , Guntur, Sai Mala , Kumar, Manish , Chaudhuri, Indrajit , Galavotti, Christine , Mahapatra, Tanmay , Ranjan, Kunal , Kumar, Gangesh , Mohanty, Sunil , Alam, Mohammed Aftab , Das, Aritra , Jiwani, Safia
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/281179 , vital:55699 , xlink:href="https://doi.org/10.1371/journal.pone.0203265"
- Description: Background: Motivation is critical to health worker performance and work quality. In Bihar, India, frontline health workers provide essential health services for the state’s poorest citizens. Yet, there is a shortfall of motivated and skilled providers and a lack of coordination between two cadres of frontline health workers and their supervisors. CARE India developed an approach aimed at improving health workers’ performance by shifting work culture and strengthening teamwork and motivation. The intervention—“Team-Based Goals and Incentives”—supported health workers to work as teams towards collective goals and rewarded success with public recognition and non-financial incentives. Methods: Thirty months after initiating the intervention, 885 health workers and 98 supervisors completed an interviewer-administered questionnaire in 38 intervention and 38 control health sub-centers in one district. The questionnaire included measures of social cohesion, teamwork attitudes, self-efficacy, job satisfaction, teamwork behaviors, equitable service delivery, taking initiative, and supervisory support. We conducted bivariate analyses to examine the impact of the intervention on these psychosocial and behavioral outcomes. Results: Results show statistically significant differences across several measures between intervention and control frontline health workers, including improved teamwork (mean = 8.8 vs. 7.3), empowerment (8.5 vs. 7.4), job satisfaction (7.1 vs. 5.99) and equitable service delivery (6.7 vs. 4.99). While fewer significant differences were found for supervisors, they reported improved teamwork (8.4 vs. 5.3), and frontline health workers reported improved fulfillment of supervisory duties by their supervisors (8.9 vs. 7.6). Both frontline health workers and supervisors found public recognition and enhanced teamwork more motivating than the non-financial incentives. Conclusions: The Team-Based Goals and Incentives model reinforces intrinsic motivation and supports improvements in the teamwork, motivation, and performance of health workers. It offers an approach to practitioners and governments for improving the work environment in a resource-constrained setting and where there are multiple cadres of health workers.
- Full Text:
- Date Issued: 2018
- Authors: Grant, Carolyn , Nawal, Dipty , Guntur, Sai Mala , Kumar, Manish , Chaudhuri, Indrajit , Galavotti, Christine , Mahapatra, Tanmay , Ranjan, Kunal , Kumar, Gangesh , Mohanty, Sunil , Alam, Mohammed Aftab , Das, Aritra , Jiwani, Safia
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/281179 , vital:55699 , xlink:href="https://doi.org/10.1371/journal.pone.0203265"
- Description: Background: Motivation is critical to health worker performance and work quality. In Bihar, India, frontline health workers provide essential health services for the state’s poorest citizens. Yet, there is a shortfall of motivated and skilled providers and a lack of coordination between two cadres of frontline health workers and their supervisors. CARE India developed an approach aimed at improving health workers’ performance by shifting work culture and strengthening teamwork and motivation. The intervention—“Team-Based Goals and Incentives”—supported health workers to work as teams towards collective goals and rewarded success with public recognition and non-financial incentives. Methods: Thirty months after initiating the intervention, 885 health workers and 98 supervisors completed an interviewer-administered questionnaire in 38 intervention and 38 control health sub-centers in one district. The questionnaire included measures of social cohesion, teamwork attitudes, self-efficacy, job satisfaction, teamwork behaviors, equitable service delivery, taking initiative, and supervisory support. We conducted bivariate analyses to examine the impact of the intervention on these psychosocial and behavioral outcomes. Results: Results show statistically significant differences across several measures between intervention and control frontline health workers, including improved teamwork (mean = 8.8 vs. 7.3), empowerment (8.5 vs. 7.4), job satisfaction (7.1 vs. 5.99) and equitable service delivery (6.7 vs. 4.99). While fewer significant differences were found for supervisors, they reported improved teamwork (8.4 vs. 5.3), and frontline health workers reported improved fulfillment of supervisory duties by their supervisors (8.9 vs. 7.6). Both frontline health workers and supervisors found public recognition and enhanced teamwork more motivating than the non-financial incentives. Conclusions: The Team-Based Goals and Incentives model reinforces intrinsic motivation and supports improvements in the teamwork, motivation, and performance of health workers. It offers an approach to practitioners and governments for improving the work environment in a resource-constrained setting and where there are multiple cadres of health workers.
- Full Text:
- Date Issued: 2018
A Case Study of Two Selected Teachers as they Integrated Dynamic Geometry Software as a Visualisation Tool in Teaching Geometry:
- Mavani, Deepak, Mavani, Beena, Schäfer, Marc
- Authors: Mavani, Deepak , Mavani, Beena , Schäfer, Marc
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141076 , vital:37942 , https://doi.org/10.1080/18117295.2018.1522716
- Description: This paper reports on an aspect of a larger research study conceptualised within a teacher development project in Mthatha, Eastern Cape Province. The project was initiated with the objective to develop appropriate skills to use dynamic geometry software (DGS) effectively and strategically as a teaching and learning tool for mathematics. The study reported in this paper aims specifically to ascertain how selected mathematics teachers integrated co-developed technologically aided visualisation tools in the observed lessons. The case study involved two teachers from different schools. The data sources were the classroom observations followed by stimulated reflective interviews with the teachers. The data were analysed to study the use of DGS visualisation tools in relation to Kilpatrick’s framework of teaching proficiency.
- Full Text:
- Date Issued: 2018
- Authors: Mavani, Deepak , Mavani, Beena , Schäfer, Marc
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141076 , vital:37942 , https://doi.org/10.1080/18117295.2018.1522716
- Description: This paper reports on an aspect of a larger research study conceptualised within a teacher development project in Mthatha, Eastern Cape Province. The project was initiated with the objective to develop appropriate skills to use dynamic geometry software (DGS) effectively and strategically as a teaching and learning tool for mathematics. The study reported in this paper aims specifically to ascertain how selected mathematics teachers integrated co-developed technologically aided visualisation tools in the observed lessons. The case study involved two teachers from different schools. The data sources were the classroom observations followed by stimulated reflective interviews with the teachers. The data were analysed to study the use of DGS visualisation tools in relation to Kilpatrick’s framework of teaching proficiency.
- Full Text:
- Date Issued: 2018
A challenge to conventional wisdom: locating agency in Angola’s and Ghana’s economic engagements with China
- Chipaike, Ronald, Bischoff, Paul, 1954-
- Authors: Chipaike, Ronald , Bischoff, Paul, 1954-
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/161537 , vital:40636 , https://0-doi.org.wam.seals.ac.za/10.1177/00219096187639223
- Description: This article makes the point that African states with significant strategic resources and democratic governance systems bargain better in economic and development assistance engagements with China and other partners. In democratic African states, non-state actors play critical complementary roles to the state, leading to multi-faceted forms of African agency. For non-democratic states, a significant limiting factor in their agency is the lack of working relationships between the state and non-state actors. Concomitantly, such states find themselves with weak bargaining and negotiating capacities. If African agency is to be assertive, then state and non-state actors should work together when engaging external partners.
- Full Text:
- Date Issued: 2018
- Authors: Chipaike, Ronald , Bischoff, Paul, 1954-
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/161537 , vital:40636 , https://0-doi.org.wam.seals.ac.za/10.1177/00219096187639223
- Description: This article makes the point that African states with significant strategic resources and democratic governance systems bargain better in economic and development assistance engagements with China and other partners. In democratic African states, non-state actors play critical complementary roles to the state, leading to multi-faceted forms of African agency. For non-democratic states, a significant limiting factor in their agency is the lack of working relationships between the state and non-state actors. Concomitantly, such states find themselves with weak bargaining and negotiating capacities. If African agency is to be assertive, then state and non-state actors should work together when engaging external partners.
- Full Text:
- Date Issued: 2018
A critical review of sanctioned knowledge production concerning abortion in Africa: Implications for feminist health psychology
- Macleod, Catriona I, Chiweshe, Malvern T, Mavuso, Jabulile M-J J
- Authors: Macleod, Catriona I , Chiweshe, Malvern T , Mavuso, Jabulile M-J J
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/444212 , vital:74207 , xlink:href="https://doi.org/10.1177/1359105316644294"
- Description: Taking a feminist health psychology approach, we conducted a systematic review of published research on abortion featured in PsycINFO over a 7-year period. We analysed the 39 articles included in the review in terms of countries in which the research was conducted, types of research, issues covered, the way the research was framed and main findings. Despite 97per cent of abortions performed in Africa being classifiable as unsafe, there has been no engagement in knowledge production about abortion in Africa from psychologists, outside of South Africa. Given this, we outline the implications of the current knowledge base for feminism, psychology and feminist health psychology in Africa.
- Full Text:
- Date Issued: 2018
- Authors: Macleod, Catriona I , Chiweshe, Malvern T , Mavuso, Jabulile M-J J
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/444212 , vital:74207 , xlink:href="https://doi.org/10.1177/1359105316644294"
- Description: Taking a feminist health psychology approach, we conducted a systematic review of published research on abortion featured in PsycINFO over a 7-year period. We analysed the 39 articles included in the review in terms of countries in which the research was conducted, types of research, issues covered, the way the research was framed and main findings. Despite 97per cent of abortions performed in Africa being classifiable as unsafe, there has been no engagement in knowledge production about abortion in Africa from psychologists, outside of South Africa. Given this, we outline the implications of the current knowledge base for feminism, psychology and feminist health psychology in Africa.
- Full Text:
- Date Issued: 2018
A Flexible Approach for the Application of Immersive Audio to an Installation Performance:
- Devonport, Sean, Foss, Richard
- Authors: Devonport, Sean , Foss, Richard
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426720 , vital:72385 , https://www.isea-international.org/symposia/1988-2022/
- Description: This paper investigates the use of the ImmerGo spatial audio system and Ethernet AVB as a platform for the creation and deployment of immersive audio content. An analysis of Ethernet AVB and ImmerGo’s features is given. This is followed by a practical implementation of ImmerGo within an installation setting of a choreographed performance. This approach provided key features such as user control from a mobile device to render positions of audio tracks and control DAW transport. The Ethernet AVB network allowed for real-time synchronized audio streaming, audio device interoperability, distributed endpoint processing and simple audio routing schemes.
- Full Text:
- Date Issued: 2018
- Authors: Devonport, Sean , Foss, Richard
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426720 , vital:72385 , https://www.isea-international.org/symposia/1988-2022/
- Description: This paper investigates the use of the ImmerGo spatial audio system and Ethernet AVB as a platform for the creation and deployment of immersive audio content. An analysis of Ethernet AVB and ImmerGo’s features is given. This is followed by a practical implementation of ImmerGo within an installation setting of a choreographed performance. This approach provided key features such as user control from a mobile device to render positions of audio tracks and control DAW transport. The Ethernet AVB network allowed for real-time synchronized audio streaming, audio device interoperability, distributed endpoint processing and simple audio routing schemes.
- Full Text:
- Date Issued: 2018
A gold–chitosan composite with low symmetry zinc phthalocyanine for enhanced singlet oxygen generation and improved photodynamic therapy activity
- Dube, Edith, Oluwole, David O, Prinsloo, Earl, Nyokong, Tebello
- Authors: Dube, Edith , Oluwole, David O , Prinsloo, Earl , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/233397 , vital:50087 , xlink:href="https://doi.org/10.1039/C8NJ00801A"
- Description: Novel zinc(II) 3-(4-((3,17,23-tris(4-(benzo[d]thiazol-2-yl)phenoxy)phthalocyanine-9-yl)oxy)phenyl)propanoic acid (complex 3) was synthesised. Complex 3 was subsequently reacted with gold nanoparticles (AuNPs), chitosan (CT) and a gold–chitosan (AuCT) hybrid to form 3-AuNPs, 3-CT and 3-AuCT, respectively. The conjugates afforded a decrease in fluorescence quantum yield with a corresponding increase in the triplet and singlet quantum yields compared to complex 3. The in vitro dark cytotoxicity and photodynamic therapy activity (PDT) of complex 3 and 3-AuCT composites were investigated against epithelial breast cancer cells (MCF-7) with both the samples showing minimum dark cytotoxicity. They both accounted for a cell viability of ≥90% at a concentration of ≤59.2 μg mL−1. 3-AuCT showed better PDT activity (compared to 3 alone) with less than 50% viable cells at a concentration of ≥29.6 μg mL−1 making it potentially applicable for PDT. On the other hand, AuCT displayed some activity against cancer cells, probably due to photothermal activity since gold is a light absorber, however it had more than 50% viable cells at a concentration of ≤59.2 μg mL−1.
- Full Text:
- Date Issued: 2018
- Authors: Dube, Edith , Oluwole, David O , Prinsloo, Earl , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/233397 , vital:50087 , xlink:href="https://doi.org/10.1039/C8NJ00801A"
- Description: Novel zinc(II) 3-(4-((3,17,23-tris(4-(benzo[d]thiazol-2-yl)phenoxy)phthalocyanine-9-yl)oxy)phenyl)propanoic acid (complex 3) was synthesised. Complex 3 was subsequently reacted with gold nanoparticles (AuNPs), chitosan (CT) and a gold–chitosan (AuCT) hybrid to form 3-AuNPs, 3-CT and 3-AuCT, respectively. The conjugates afforded a decrease in fluorescence quantum yield with a corresponding increase in the triplet and singlet quantum yields compared to complex 3. The in vitro dark cytotoxicity and photodynamic therapy activity (PDT) of complex 3 and 3-AuCT composites were investigated against epithelial breast cancer cells (MCF-7) with both the samples showing minimum dark cytotoxicity. They both accounted for a cell viability of ≥90% at a concentration of ≤59.2 μg mL−1. 3-AuCT showed better PDT activity (compared to 3 alone) with less than 50% viable cells at a concentration of ≥29.6 μg mL−1 making it potentially applicable for PDT. On the other hand, AuCT displayed some activity against cancer cells, probably due to photothermal activity since gold is a light absorber, however it had more than 50% viable cells at a concentration of ≤59.2 μg mL−1.
- Full Text:
- Date Issued: 2018
A missing link in the estuarine nitrogen cycle?: coupled nitrification-denitrification mediated by suspended particulate matter
- Zhu, Weijing, Wang, Cheng, Hill, Jaclyn M, He, Yangyang, Tao, Bangyi, Mao, Zhihua, Wu, Weixiang
- Authors: Zhu, Weijing , Wang, Cheng , Hill, Jaclyn M , He, Yangyang , Tao, Bangyi , Mao, Zhihua , Wu, Weixiang
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68368 , vital:29244 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-018-20688-4
- Description: In estuarine and coastal ecosystems, the majority of previous studies have considered coupled nitrification-denitrification (CND) processes to be exclusively sediment based, with little focus onsuspended particulate matter (SPM) in the water column. Here, we present evidence of CND processes in the water column of Hangzhou Bay, one of the largest macrotidal embayments in the world.
- Full Text:
- Date Issued: 2018
- Authors: Zhu, Weijing , Wang, Cheng , Hill, Jaclyn M , He, Yangyang , Tao, Bangyi , Mao, Zhihua , Wu, Weixiang
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68368 , vital:29244 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-018-20688-4
- Description: In estuarine and coastal ecosystems, the majority of previous studies have considered coupled nitrification-denitrification (CND) processes to be exclusively sediment based, with little focus onsuspended particulate matter (SPM) in the water column. Here, we present evidence of CND processes in the water column of Hangzhou Bay, one of the largest macrotidal embayments in the world.
- Full Text:
- Date Issued: 2018
A molecular phylogeny of the cicadas (Hemiptera: Cicadidae) with a review of tribe and subfamily classification:
- Marshall, David C, Moulds, Max, Hill, Kathy B R, Price, Benjamin W, Wade, Elizabeth J, Owen, Christopher L, Goemans, Geert, Marathe, Kiran, Sarkar, Vivek, Cooley, John R, Sanborn, Allen F, Kunte, Krushnamegh, Villet, Martin H, Simon, Chris
- Authors: Marshall, David C , Moulds, Max , Hill, Kathy B R , Price, Benjamin W , Wade, Elizabeth J , Owen, Christopher L , Goemans, Geert , Marathe, Kiran , Sarkar, Vivek , Cooley, John R , Sanborn, Allen F , Kunte, Krushnamegh , Villet, Martin H , Simon, Chris
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140601 , vital:37902 , DOI: 10.11646/zootaxa.4424.1.1
- Description: A molecular phylogeny and a review of family-group classification are presented for 137 species (ca. 125 genera) of the insect family Cicadidae, the true cicadas, plus two species of hairy cicadas (Tettigarctidae) and two outgroup species from Cercopidae. Five genes, two of them mitochondrial, comprise the 4992 base-pair molecular dataset. Maximum-likelihood and Bayesian phylogenetic results are shown, including analyses to address potential base composition bias. Tettigarcta is confirmed as the sister-clade of the Cicadidae and support is found for three subfamilies identified in an earlier morphological cladistic analysis. A set of paraphyletic deep-level clades formed by African genera are together named as Tettigomyiinae n. stat. Taxonomic reassignments of genera and tribes are made where morphological examination confirms incorrect placements suggested by the molecular tree, and 11 new tribes are defined (Arenopsaltriini n. tribe, Durangonini n. tribe, Katoini n. tribe, Lacetasini n. tribe, Macrotristriini n. tribe, Malagasiini n. tribe, Nelcyndanini n. tribe, Pagiphorini n. tribe, Pictilini n. tribe, Psaltodini n. tribe, and Selymbriini n. tribe). Tribe Tacuini n. syn. is synonymized with Cryptotympanini, and Tryellina n. syn. is synonymized with an expanded Tribe Lamotialnini. Tribe Hyantiini n. syn. is synonymized with Fidicinini. Tribe Sinosenini is transferred to Cicadinae from Cicadettinae, Cicadatrini is moved to Cicadettinae from Cicadinae, and Ydiellini and Tettigomyiini are transferred to Tettigomyiinae n. stat from Cicadettinae. While the subfamily Cicadinae, historically defined by the presence of timbal covers, is weakly supported in the molecular tree, high taxonomic rank is not supported for several earlier clades based on unique morphology associated with sound production.
- Full Text:
- Date Issued: 2018
- Authors: Marshall, David C , Moulds, Max , Hill, Kathy B R , Price, Benjamin W , Wade, Elizabeth J , Owen, Christopher L , Goemans, Geert , Marathe, Kiran , Sarkar, Vivek , Cooley, John R , Sanborn, Allen F , Kunte, Krushnamegh , Villet, Martin H , Simon, Chris
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140601 , vital:37902 , DOI: 10.11646/zootaxa.4424.1.1
- Description: A molecular phylogeny and a review of family-group classification are presented for 137 species (ca. 125 genera) of the insect family Cicadidae, the true cicadas, plus two species of hairy cicadas (Tettigarctidae) and two outgroup species from Cercopidae. Five genes, two of them mitochondrial, comprise the 4992 base-pair molecular dataset. Maximum-likelihood and Bayesian phylogenetic results are shown, including analyses to address potential base composition bias. Tettigarcta is confirmed as the sister-clade of the Cicadidae and support is found for three subfamilies identified in an earlier morphological cladistic analysis. A set of paraphyletic deep-level clades formed by African genera are together named as Tettigomyiinae n. stat. Taxonomic reassignments of genera and tribes are made where morphological examination confirms incorrect placements suggested by the molecular tree, and 11 new tribes are defined (Arenopsaltriini n. tribe, Durangonini n. tribe, Katoini n. tribe, Lacetasini n. tribe, Macrotristriini n. tribe, Malagasiini n. tribe, Nelcyndanini n. tribe, Pagiphorini n. tribe, Pictilini n. tribe, Psaltodini n. tribe, and Selymbriini n. tribe). Tribe Tacuini n. syn. is synonymized with Cryptotympanini, and Tryellina n. syn. is synonymized with an expanded Tribe Lamotialnini. Tribe Hyantiini n. syn. is synonymized with Fidicinini. Tribe Sinosenini is transferred to Cicadinae from Cicadettinae, Cicadatrini is moved to Cicadettinae from Cicadinae, and Ydiellini and Tettigomyiini are transferred to Tettigomyiinae n. stat from Cicadettinae. While the subfamily Cicadinae, historically defined by the presence of timbal covers, is weakly supported in the molecular tree, high taxonomic rank is not supported for several earlier clades based on unique morphology associated with sound production.
- Full Text:
- Date Issued: 2018
A New Synthetic Method for Tetraazatricyclic Derivatives and Evaluation of Their Biological Properties
- Odame, Felix, Betz, Richard, Hosten, Eric C, Krause, Jason, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D, Sayed, Yasien, Frost, P Carminita, Lobb, Kevin A, Tshentu, Zenixole R
- Authors: Odame, Felix , Betz, Richard , Hosten, Eric C , Krause, Jason , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D , Sayed, Yasien , Frost, P Carminita , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123189 , vital:35413 , https://doi.org/10.1002/slct.201802930
- Description: Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2–8 μM without any cytotoxic effects. Compounds 10 (MIC90; 0.9 μM), 11 (MIC90; 0.2 μM), 12 (MIC90; 0.8 μM) and compound 15 (MIC90; 0.8 μM), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions −1 and −3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
- Full Text:
- Date Issued: 2018
- Authors: Odame, Felix , Betz, Richard , Hosten, Eric C , Krause, Jason , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D , Sayed, Yasien , Frost, P Carminita , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123189 , vital:35413 , https://doi.org/10.1002/slct.201802930
- Description: Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2–8 μM without any cytotoxic effects. Compounds 10 (MIC90; 0.9 μM), 11 (MIC90; 0.2 μM), 12 (MIC90; 0.8 μM) and compound 15 (MIC90; 0.8 μM), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions −1 and −3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
- Full Text:
- Date Issued: 2018
A peaceful revenge: Achieving structural and agential transformation in a South African context using cognitive justice and emancipatory social learning
- Authors: Burt, Jane C , James, Anna
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/392049 , vital:68717 , xlink:href="https://doi.org/10.1080/14767430.2018.1550312"
- Description: This is an account of the emancipatory struggle that faces agents who seek to change the oppressive social structures associated with neo-liberalism. We begin by ‘digging amongst the bones’ of the calls for resistance that have been declared dead or assimilated/co-opted by neoliberal theorists. This leads us to unearth, then utilize, Paulo Freire’s Pedagogy of the Oppressed, Steve Biko’s Black Consciousness and Shiv Visvanathan's ideas; which are examples of Roy Bhaskar’s transformative dialectic. We argue, using examples, that cognitive justice – a concept common to each of our chosen theorists – is vital in enabling emancipatory social learning. By embracing cognitive justice, the agents gained confidence, which led to their increased ability to champion community and non-academic knowledge. It also uncovered structural tensions – attendant in neoliberalism – around privilege. By articulating these tensions, the participants were able to ‘come closer together’. Such processes, initiated by ensuring cognitive justice, are possible steps in achieving universal solidarity; which is likely to be a necessary step along the path of achieving emancipation.
- Full Text:
- Date Issued: 2018
- Authors: Burt, Jane C , James, Anna
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/392049 , vital:68717 , xlink:href="https://doi.org/10.1080/14767430.2018.1550312"
- Description: This is an account of the emancipatory struggle that faces agents who seek to change the oppressive social structures associated with neo-liberalism. We begin by ‘digging amongst the bones’ of the calls for resistance that have been declared dead or assimilated/co-opted by neoliberal theorists. This leads us to unearth, then utilize, Paulo Freire’s Pedagogy of the Oppressed, Steve Biko’s Black Consciousness and Shiv Visvanathan's ideas; which are examples of Roy Bhaskar’s transformative dialectic. We argue, using examples, that cognitive justice – a concept common to each of our chosen theorists – is vital in enabling emancipatory social learning. By embracing cognitive justice, the agents gained confidence, which led to their increased ability to champion community and non-academic knowledge. It also uncovered structural tensions – attendant in neoliberalism – around privilege. By articulating these tensions, the participants were able to ‘come closer together’. Such processes, initiated by ensuring cognitive justice, are possible steps in achieving universal solidarity; which is likely to be a necessary step along the path of achieving emancipation.
- Full Text:
- Date Issued: 2018
A preliminary study of minimal-contention locks
- Machanick, Philip, Mbiyavanga, Mamana
- Authors: Machanick, Philip , Mbiyavanga, Mamana
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439093 , vital:73544 , https://doi.org/10.1145/3278681.3278713
- Description: As multicore CPUs become more common, scalable synchronization primitives have wider use and ideas previously used in large-scale computation are worth re-opening for wider use. In this paper I explore one approach to scalable synchronization, a minimal-contention lock (M-lock). The key idea is to avoid spinning on a global variable but instead for each blocked task (process or thread) to spin on a local lock representing the task that immediately preceded it in attempting to acquire the lock. This creates an ordering based on the order in which tasks attempt to acquire the lock, preventing starvation. The only globally shared variable is a pointer to the next local lock to be contended for. Each contending task swaps the value of this pointer for a pointer to its own variable. It spins on the variable previously pointed to by the global pointer. Each waiting task spins on a lock only seen by itself and the owner of that lock variable. While a task is spinning, the lock variable can be held in its local cache until invalidated by the lock owner when it unsets the lock. Consequently, the amount of bus traffic is considerably less than with a spinlock, which has the pernicious feature that the task releasing the lock is delayed by all the other bus traffic arising from contention for the lock. An MCS lock has similar properties but is more complicated and requires more memory contention-causing operations. This paper outlines the design of the M-lock and provides a preliminary performance analysis.
- Full Text:
- Date Issued: 2018
- Authors: Machanick, Philip , Mbiyavanga, Mamana
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439093 , vital:73544 , https://doi.org/10.1145/3278681.3278713
- Description: As multicore CPUs become more common, scalable synchronization primitives have wider use and ideas previously used in large-scale computation are worth re-opening for wider use. In this paper I explore one approach to scalable synchronization, a minimal-contention lock (M-lock). The key idea is to avoid spinning on a global variable but instead for each blocked task (process or thread) to spin on a local lock representing the task that immediately preceded it in attempting to acquire the lock. This creates an ordering based on the order in which tasks attempt to acquire the lock, preventing starvation. The only globally shared variable is a pointer to the next local lock to be contended for. Each contending task swaps the value of this pointer for a pointer to its own variable. It spins on the variable previously pointed to by the global pointer. Each waiting task spins on a lock only seen by itself and the owner of that lock variable. While a task is spinning, the lock variable can be held in its local cache until invalidated by the lock owner when it unsets the lock. Consequently, the amount of bus traffic is considerably less than with a spinlock, which has the pernicious feature that the task releasing the lock is delayed by all the other bus traffic arising from contention for the lock. An MCS lock has similar properties but is more complicated and requires more memory contention-causing operations. This paper outlines the design of the M-lock and provides a preliminary performance analysis.
- Full Text:
- Date Issued: 2018
A song for the South: also defining birdsong in global terms
- Bonnevie, Bo T, Craig, Adrian J F K
- Authors: Bonnevie, Bo T , Craig, Adrian J F K
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448759 , vital:74758 , https://doi.org/10.1111/ibi.12627
- Description: The article presents information on the importance of birdsongs, highlighting the structured vocalization required for mate attraction and defending of territory by male birds. Topics include the variations of themes in birdsongs during intraspecific communication, song acquisitions by the songbirds, and the impact of song learning by birds.
- Full Text:
- Date Issued: 2018
- Authors: Bonnevie, Bo T , Craig, Adrian J F K
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448759 , vital:74758 , https://doi.org/10.1111/ibi.12627
- Description: The article presents information on the importance of birdsongs, highlighting the structured vocalization required for mate attraction and defending of territory by male birds. Topics include the variations of themes in birdsongs during intraspecific communication, song acquisitions by the songbirds, and the impact of song learning by birds.
- Full Text:
- Date Issued: 2018
A study of the kinetics of a high temperature thermoluminescence peak in annealed natural quartz
- Thomas, Sunil, Chithambo, Makaiko L
- Authors: Thomas, Sunil , Chithambo, Makaiko L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/110007 , vital:33213 , DOI: 10.1016/j.jlumin.2018.08.077
- Description: Thermoluminescence of a high temperature secondary glow-peak in natural quartz annealed at 900 °C is reported. The glow-curve of a sample irradiated to 10 Gy and measured at 1 °C/s shows three peaks; the main peak at 71 °C and two other weaker-intensity peaks at 125 °C and 177 °C. For reference, the peaks are labelled as I, II and III. This study is concerned with the secondary peak at 177 °C (peak III). The electron trap responsible for peak III is stable at ambient temperature as determined by monitoring the peak intensity after various delays between irradiation and measurement. The activation energy and frequency factor of the peak were estimated as ~1.24 eV and ~10¹² s⁻¹ respectively. The dose response of the peak in the range 1–300 Gy is sublinear. The influence of either partial heating or irradiation dose on the peak position suggest that the peak follows non-first-order kinetics.
- Full Text: false
- Date Issued: 2018
- Authors: Thomas, Sunil , Chithambo, Makaiko L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/110007 , vital:33213 , DOI: 10.1016/j.jlumin.2018.08.077
- Description: Thermoluminescence of a high temperature secondary glow-peak in natural quartz annealed at 900 °C is reported. The glow-curve of a sample irradiated to 10 Gy and measured at 1 °C/s shows three peaks; the main peak at 71 °C and two other weaker-intensity peaks at 125 °C and 177 °C. For reference, the peaks are labelled as I, II and III. This study is concerned with the secondary peak at 177 °C (peak III). The electron trap responsible for peak III is stable at ambient temperature as determined by monitoring the peak intensity after various delays between irradiation and measurement. The activation energy and frequency factor of the peak were estimated as ~1.24 eV and ~10¹² s⁻¹ respectively. The dose response of the peak in the range 1–300 Gy is sublinear. The influence of either partial heating or irradiation dose on the peak position suggest that the peak follows non-first-order kinetics.
- Full Text: false
- Date Issued: 2018
A study on the creative industry as a pillar of sustained growth and diversification: the film and music sectors in Jamaica: lessons from case studies of successful firms and ventures
- Hendrickson, Michael, Stanley Niaah, Sonjah
- Authors: Hendrickson, Michael , Stanley Niaah, Sonjah
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146992 , vital:38583 , https://repositorio.cepal.org/handle/11362/43410
- Description: In 2007 the Caribbean Community (CARICOM) published ‘The Cultural Industries in CARICOM: Trade and Development Challenges’ report, which stated that the film and music industries refer to “aesthetic, identity, and copyrightable goods, services and intellectual property. They represent a wide array of activities that make and circulate sounds, words, and images or a combination of these. It applies to artistic, creative, and copyright works that are for sale, license, commercialisation, or display in some marketplace or public arena.” Using the definition in the CARICOM report, this study will identify the critical success factors that have resulted in the global competitiveness and sustainability of individuals, firms and ventures within the music and film subsectors in Jamaica. To anchor the study of the individual firms and ventures, the study first evaluates the historical evolution and recent trends in the development of the music and film subsectors, including their economic contribution and the main challenges and opportunities for their further development and lessons learned.
- Full Text:
- Date Issued: 2018
- Authors: Hendrickson, Michael , Stanley Niaah, Sonjah
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146992 , vital:38583 , https://repositorio.cepal.org/handle/11362/43410
- Description: In 2007 the Caribbean Community (CARICOM) published ‘The Cultural Industries in CARICOM: Trade and Development Challenges’ report, which stated that the film and music industries refer to “aesthetic, identity, and copyrightable goods, services and intellectual property. They represent a wide array of activities that make and circulate sounds, words, and images or a combination of these. It applies to artistic, creative, and copyright works that are for sale, license, commercialisation, or display in some marketplace or public arena.” Using the definition in the CARICOM report, this study will identify the critical success factors that have resulted in the global competitiveness and sustainability of individuals, firms and ventures within the music and film subsectors in Jamaica. To anchor the study of the individual firms and ventures, the study first evaluates the historical evolution and recent trends in the development of the music and film subsectors, including their economic contribution and the main challenges and opportunities for their further development and lessons learned.
- Full Text:
- Date Issued: 2018
Action for increasing energy-saving behaviour in student residences at Rhodes University, South Africa
- Ancha, Angel, Bulunga, Lindelwa, Thondhlana, Gladman
- Authors: Ancha, Angel , Bulunga, Lindelwa , Thondhlana, Gladman
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67801 , vital:29146 , https://doi.org/10.1108/IJSHE-07-2017-0107
- Description: Publisher version , Purpose: In response to increasing energy demand and financial constraints to invest in green infrastructure, behaviour change energy-saving interventions are increasingly being considered as a tool for encouraging pro-environmental behaviour in campus residences. This paper aims to report on a pilot programme aimed at reducing energy consumption via behaviour change interventions, variably applied in residences at Rhodes University, South Africa. Design/methodology/approach: Data were collected via structured questionnaires, energy consumption records and post-intervention programme focus group discussions. Findings: Participant residences that received a mix of different interventions in the forms of pamphlets, face-to-face discussions, incentives and feedback recorded more energy reductions of up to 9 per cent than residences that received a single or no intervention. In post-experiment discussions, students cited personal, institutional and structural barriers to pro-environmental energy-use behaviour. Practical implications: Overall, the results of this study suggest that information provision of energy-saving tips combined with regular feedback and incentives can result in energy-use reductions in university residences, which may yield environmental and economic benefits for universities, but addressing barriers to pro-environmental behaviour might maximise the results. Originality/value: Given the lack of literature on energy conservation in the global South universities, this study provides the basis for discussing the potential for using behavioural interventions in universities for stirring pathways towards sustainability.
- Full Text: false
- Date Issued: 2018
- Authors: Ancha, Angel , Bulunga, Lindelwa , Thondhlana, Gladman
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67801 , vital:29146 , https://doi.org/10.1108/IJSHE-07-2017-0107
- Description: Publisher version , Purpose: In response to increasing energy demand and financial constraints to invest in green infrastructure, behaviour change energy-saving interventions are increasingly being considered as a tool for encouraging pro-environmental behaviour in campus residences. This paper aims to report on a pilot programme aimed at reducing energy consumption via behaviour change interventions, variably applied in residences at Rhodes University, South Africa. Design/methodology/approach: Data were collected via structured questionnaires, energy consumption records and post-intervention programme focus group discussions. Findings: Participant residences that received a mix of different interventions in the forms of pamphlets, face-to-face discussions, incentives and feedback recorded more energy reductions of up to 9 per cent than residences that received a single or no intervention. In post-experiment discussions, students cited personal, institutional and structural barriers to pro-environmental energy-use behaviour. Practical implications: Overall, the results of this study suggest that information provision of energy-saving tips combined with regular feedback and incentives can result in energy-use reductions in university residences, which may yield environmental and economic benefits for universities, but addressing barriers to pro-environmental behaviour might maximise the results. Originality/value: Given the lack of literature on energy conservation in the global South universities, this study provides the basis for discussing the potential for using behavioural interventions in universities for stirring pathways towards sustainability.
- Full Text: false
- Date Issued: 2018
Adsorptive removal of ciprofloxacin and isoniazid from aqueous solution
- Dube, Cyril S, Tandlich, Roman, Wilhelmi, Brendan S
- Authors: Dube, Cyril S , Tandlich, Roman , Wilhelmi, Brendan S
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76846 , vital:30629 , https://doi.org/10.2478/nbec-2018-0002
- Description: This paper describes study of ciprofloxacin and isoniazid removal from aqueous solutions using coal fly ash (FA), kaolinite, perlite, talc and vermiculite. The adsorptive features of the adsorbents were evaluated for ciprofloxacin and isoniazid with regards to the effects of contact time, pH, the solid/liquid ratio and antibiotic concentration. All adsorbents were sterilised by dry heat before use to avoid the proliferation of antimicrobial resistance by the bacteria present on the adsorbents during experiments. The regression correlation coefficients indicate that the Langmuir model gives the best fit for the sorption of both antibiotics onto FA and talc, ciprofloxacin onto kaolinite, and isoniazid onto perlite and vermiculite with R2 values ranging from 0.908 – 0.999. The Freundlich isotherm best describes the sorption of ciprofloxacin onto vermiculite and isoniazid onto kaolinite with R2 values of 0.999 for both. The Tempkin model best describes the sorption of ciprofloxacin onto perlite with an R2 = 0.997. The values of the Freundlich exponent, 1/n, range from 0.221 – 0.998, indicating a favourable adsorption of ciprofloxacin and isoniazid onto the adsorbents. The heat of sorption, B, calculated from the Temkin plots has values ranging from 0.018 – 10.460 J/mol, indicating a physical adsorption process (physisorption). Adsorption equilibrium was achieved after 30 min for both antibiotics and the kinetic data obtained conforms best to the pseudo-second order equation with R2 values ranging from 0.998 – 0.999. The removal of ciprofloxacin and isoniazid by all adsorbents except FA was strongly influenced by the pH suggesting that electrostatic interactions play a major role in the adsorption processes.
- Full Text:
- Date Issued: 2018
- Authors: Dube, Cyril S , Tandlich, Roman , Wilhelmi, Brendan S
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76846 , vital:30629 , https://doi.org/10.2478/nbec-2018-0002
- Description: This paper describes study of ciprofloxacin and isoniazid removal from aqueous solutions using coal fly ash (FA), kaolinite, perlite, talc and vermiculite. The adsorptive features of the adsorbents were evaluated for ciprofloxacin and isoniazid with regards to the effects of contact time, pH, the solid/liquid ratio and antibiotic concentration. All adsorbents were sterilised by dry heat before use to avoid the proliferation of antimicrobial resistance by the bacteria present on the adsorbents during experiments. The regression correlation coefficients indicate that the Langmuir model gives the best fit for the sorption of both antibiotics onto FA and talc, ciprofloxacin onto kaolinite, and isoniazid onto perlite and vermiculite with R2 values ranging from 0.908 – 0.999. The Freundlich isotherm best describes the sorption of ciprofloxacin onto vermiculite and isoniazid onto kaolinite with R2 values of 0.999 for both. The Tempkin model best describes the sorption of ciprofloxacin onto perlite with an R2 = 0.997. The values of the Freundlich exponent, 1/n, range from 0.221 – 0.998, indicating a favourable adsorption of ciprofloxacin and isoniazid onto the adsorbents. The heat of sorption, B, calculated from the Temkin plots has values ranging from 0.018 – 10.460 J/mol, indicating a physical adsorption process (physisorption). Adsorption equilibrium was achieved after 30 min for both antibiotics and the kinetic data obtained conforms best to the pseudo-second order equation with R2 values ranging from 0.998 – 0.999. The removal of ciprofloxacin and isoniazid by all adsorbents except FA was strongly influenced by the pH suggesting that electrostatic interactions play a major role in the adsorption processes.
- Full Text:
- Date Issued: 2018
Adult binge drinking: rate, frequency and intensity in Buffalo City Metropolitan Municipality, South Africa
- Owolabi, Eyitayo Omolara, Goona, Daniel Ter, Adeniyi, Oladele Vincent, Seekoea, Eunice
- Authors: Owolabi, Eyitayo Omolara , Goona, Daniel Ter , Adeniyi, Oladele Vincent , Seekoea, Eunice
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4944 , vital:44305 , https://doi.org/10.1080/20786190.2017.1382970
- Description: This study was conducted to explore views about the execution of powers and functions of the police in the light of related challenges. This study made use of data from a total of 83 adult participants (a survey involving 73 individuals, and 10 in-depth interviews), including males and females of diverse occupational backgrounds from Bindura and Mount Darwin policing districts in Zimbabwe. A closed-ended, mostly Likert-scale-based questionnaire was used to collect data about the prevalent forms of police abuse of powers and functions, while an in-depth interview guide was provided to harvest information qualitatively. Findings reveal that police officers abuse their powers through unlawful arrests, arbitrary search and seizure, excessive use of force, unlawful methods of investigation, and ill treatment of detainees. Though not as prevalent as other forms of abuse, malicious criminal prosecution and partisan policing were also cited.K EYWOR DS: powers, abuse, function, police, Zimbabwe
- Full Text:
- Date Issued: 2018
- Authors: Owolabi, Eyitayo Omolara , Goona, Daniel Ter , Adeniyi, Oladele Vincent , Seekoea, Eunice
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4944 , vital:44305 , https://doi.org/10.1080/20786190.2017.1382970
- Description: This study was conducted to explore views about the execution of powers and functions of the police in the light of related challenges. This study made use of data from a total of 83 adult participants (a survey involving 73 individuals, and 10 in-depth interviews), including males and females of diverse occupational backgrounds from Bindura and Mount Darwin policing districts in Zimbabwe. A closed-ended, mostly Likert-scale-based questionnaire was used to collect data about the prevalent forms of police abuse of powers and functions, while an in-depth interview guide was provided to harvest information qualitatively. Findings reveal that police officers abuse their powers through unlawful arrests, arbitrary search and seizure, excessive use of force, unlawful methods of investigation, and ill treatment of detainees. Though not as prevalent as other forms of abuse, malicious criminal prosecution and partisan policing were also cited.K EYWOR DS: powers, abuse, function, police, Zimbabwe
- Full Text:
- Date Issued: 2018
Afrikanische Entwicklungsalternativen: Ubuntu und die Post-Development-Debatte
- Authors: Matthews, Sally
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142157 , vital:38054 , DOI: 10.3224/peripherie.v38i2.03
- Description: In post-development theory, ubuntu is often cited as an example of an “alternative to development”. This article investigates whether ubuntu can play this role and what to think of the demand for alternatives to development in general. In order to do this, the paper fi rst deals with central aspects of postdevelopment theory and the debate about ubuntu. Although the concept fi ts well into a post-development perspective, the attempts to contrast ubuntu with Western ideas and ways of life are often fueled by the desire to rekindle an original, pre-colonial, authentic African philosophy. Yet discourses on Africa are always embedded in Western discourses, so this opposition reproduces precisely those dichotomies it aims to fi ght. More generally, this also holds true for the idea of “alternatives to development”, which postulate an essential opposition to “development”. This, however, denies claims for equal rights and participation at the root of demands for “development”. The struggle for these claims cannot be fought beyond the existing global order. Instead of engaging in romanticizing projections about an Africa beyond “development”, people’s views and needs should be taken as the starting point for the struggle against injustice and inequality.
- Full Text:
- Date Issued: 2018
- Authors: Matthews, Sally
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142157 , vital:38054 , DOI: 10.3224/peripherie.v38i2.03
- Description: In post-development theory, ubuntu is often cited as an example of an “alternative to development”. This article investigates whether ubuntu can play this role and what to think of the demand for alternatives to development in general. In order to do this, the paper fi rst deals with central aspects of postdevelopment theory and the debate about ubuntu. Although the concept fi ts well into a post-development perspective, the attempts to contrast ubuntu with Western ideas and ways of life are often fueled by the desire to rekindle an original, pre-colonial, authentic African philosophy. Yet discourses on Africa are always embedded in Western discourses, so this opposition reproduces precisely those dichotomies it aims to fi ght. More generally, this also holds true for the idea of “alternatives to development”, which postulate an essential opposition to “development”. This, however, denies claims for equal rights and participation at the root of demands for “development”. The struggle for these claims cannot be fought beyond the existing global order. Instead of engaging in romanticizing projections about an Africa beyond “development”, people’s views and needs should be taken as the starting point for the struggle against injustice and inequality.
- Full Text:
- Date Issued: 2018
Allosteric Modulation of Human Hsp90α Conformational Dynamics:
- Penkler, David L, Atilgan, Canan, Tastan Bishop, Özlem
- Authors: Penkler, David L , Atilgan, Canan , Tastan Bishop, Özlem
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162936 , vital:40998 , https://doi.org/10.1021/acs.jcim.7b00630
- Description: Central to Hsp90’s biological function is its ability to interconvert between various conformational states. Drug targeting of Hsp90’s regulatory mechanisms, including its modulation by cochaperone association, presents as an attractive therapeutic strategy for Hsp90 associated pathologies. In this study, we utilized homology modeling techniques to calculate full-length structures of human Hsp90α in closed and partially open conformations and used these structures as a basis for several molecular dynamics based analyses aimed at elucidating allosteric mechanisms and modulation sites in human Hsp90α.
- Full Text:
- Date Issued: 2018
- Authors: Penkler, David L , Atilgan, Canan , Tastan Bishop, Özlem
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162936 , vital:40998 , https://doi.org/10.1021/acs.jcim.7b00630
- Description: Central to Hsp90’s biological function is its ability to interconvert between various conformational states. Drug targeting of Hsp90’s regulatory mechanisms, including its modulation by cochaperone association, presents as an attractive therapeutic strategy for Hsp90 associated pathologies. In this study, we utilized homology modeling techniques to calculate full-length structures of human Hsp90α in closed and partially open conformations and used these structures as a basis for several molecular dynamics based analyses aimed at elucidating allosteric mechanisms and modulation sites in human Hsp90α.
- Full Text:
- Date Issued: 2018