Beneficial effects of medicinal plants in fish diseases
- Stratev, Deyan, Zhelyazkov, Georgi, Noundou, Xavier S, Krause, Rui W M
- Authors: Stratev, Deyan , Zhelyazkov, Georgi , Noundou, Xavier S , Krause, Rui W M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126177 , vital:35856 , https://doi.org/10.1007/s10499-017-0219-x
- Description: Fish are constantly in contact with pathogens inhabiting water. High populationdensity as well as poor hydrodynamic conditions and feeding lead to an increased sensitivitytowards infections. In order to prevent major economic losses due to diseases, variousmedications are used for treatment and prevention of infections. The use of antimicrobialdrugs in aquacultures could lead to emergence of resistance in pathogenic microorganisms.Alternatives are being sought over the last few years to replace antibiotics, and medicinalplants are one of available options for this purpose. These plants are rich in secondarymetabolites and phytochemical compounds, which have an effect against viral, bacterial, andparasitic diseases in fish. Their main advantage is their natural origin and most of these plantsdo not represent threat for human health, the fish, and the environment. The goal of this reviewis to present information on the treatment of viral, bacterial, and parasitic diseases in fishthrough medicinal plants, with focus on the mechanisms of action of the identified secondarymetabolites, fractions, or plant extracts.
- Full Text:
- Date Issued: 2018
- Authors: Stratev, Deyan , Zhelyazkov, Georgi , Noundou, Xavier S , Krause, Rui W M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126177 , vital:35856 , https://doi.org/10.1007/s10499-017-0219-x
- Description: Fish are constantly in contact with pathogens inhabiting water. High populationdensity as well as poor hydrodynamic conditions and feeding lead to an increased sensitivitytowards infections. In order to prevent major economic losses due to diseases, variousmedications are used for treatment and prevention of infections. The use of antimicrobialdrugs in aquacultures could lead to emergence of resistance in pathogenic microorganisms.Alternatives are being sought over the last few years to replace antibiotics, and medicinalplants are one of available options for this purpose. These plants are rich in secondarymetabolites and phytochemical compounds, which have an effect against viral, bacterial, andparasitic diseases in fish. Their main advantage is their natural origin and most of these plantsdo not represent threat for human health, the fish, and the environment. The goal of this reviewis to present information on the treatment of viral, bacterial, and parasitic diseases in fishthrough medicinal plants, with focus on the mechanisms of action of the identified secondarymetabolites, fractions, or plant extracts.
- Full Text:
- Date Issued: 2018
Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs
- Lakkakula, Jaya R, Kurapati, Rajendra, Tynga, Ivan, Krause, Rui W M, Abrahamse, Heidi, Raichur, Ashok M
- Authors: Lakkakula, Jaya R , Kurapati, Rajendra , Tynga, Ivan , Krause, Rui W M , Abrahamse, Heidi , Raichur, Ashok M
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125435 , vital:35783 , https://doi.org/10.1039/C6RA12951J
- Description: Porous CaCO3 microparticles have been used earlier for sustained drug release of hydrophilic drugs but have certain drawbacks for use with hydrophobic drugs. Hence, to overcome these drawbacks, a novel composite of CaCO3 along with cyclodextrin (CD–CaCO3) for the delivery of hydrophobic drugs was developed. Cyclodextrins (CDs), when incorporated within CaCO3, increased the porosity and surface area of microparticles thereby enhancing the encapsulation efficiency of hydrophobic drugs (5-Fluorouracil or Na-L-thyroxine) by forming inclusion complexes with cyclodextrin. Thermogravimetric and FTIR studies confirmed the interaction between the cyclodextrin and CaCO3 microparticles. Raman spectra confirmed the peak of vaterite crystals before and after loading of hydrophobic drugs within the composite. In vitro release studies when performed at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) showed release at low pH as CaCO3 is soluble at acidic pH unlike slower release at basic pH. Release kinetics followed a Higuchi kinetic model at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) respectively.
- Full Text:
- Date Issued: 2016
- Authors: Lakkakula, Jaya R , Kurapati, Rajendra , Tynga, Ivan , Krause, Rui W M , Abrahamse, Heidi , Raichur, Ashok M
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125435 , vital:35783 , https://doi.org/10.1039/C6RA12951J
- Description: Porous CaCO3 microparticles have been used earlier for sustained drug release of hydrophilic drugs but have certain drawbacks for use with hydrophobic drugs. Hence, to overcome these drawbacks, a novel composite of CaCO3 along with cyclodextrin (CD–CaCO3) for the delivery of hydrophobic drugs was developed. Cyclodextrins (CDs), when incorporated within CaCO3, increased the porosity and surface area of microparticles thereby enhancing the encapsulation efficiency of hydrophobic drugs (5-Fluorouracil or Na-L-thyroxine) by forming inclusion complexes with cyclodextrin. Thermogravimetric and FTIR studies confirmed the interaction between the cyclodextrin and CaCO3 microparticles. Raman spectra confirmed the peak of vaterite crystals before and after loading of hydrophobic drugs within the composite. In vitro release studies when performed at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) showed release at low pH as CaCO3 is soluble at acidic pH unlike slower release at basic pH. Release kinetics followed a Higuchi kinetic model at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) respectively.
- Full Text:
- Date Issued: 2016
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