A Flexible Approach for the Application of Immersive Audio to an Installation Performance:
- Devonport, Sean, Foss, Richard
- Authors: Devonport, Sean , Foss, Richard
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426720 , vital:72385 , https://www.isea-international.org/symposia/1988-2022/
- Description: This paper investigates the use of the ImmerGo spatial audio system and Ethernet AVB as a platform for the creation and deployment of immersive audio content. An analysis of Ethernet AVB and ImmerGo’s features is given. This is followed by a practical implementation of ImmerGo within an installation setting of a choreographed performance. This approach provided key features such as user control from a mobile device to render positions of audio tracks and control DAW transport. The Ethernet AVB network allowed for real-time synchronized audio streaming, audio device interoperability, distributed endpoint processing and simple audio routing schemes.
- Full Text:
- Authors: Devonport, Sean , Foss, Richard
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426720 , vital:72385 , https://www.isea-international.org/symposia/1988-2022/
- Description: This paper investigates the use of the ImmerGo spatial audio system and Ethernet AVB as a platform for the creation and deployment of immersive audio content. An analysis of Ethernet AVB and ImmerGo’s features is given. This is followed by a practical implementation of ImmerGo within an installation setting of a choreographed performance. This approach provided key features such as user control from a mobile device to render positions of audio tracks and control DAW transport. The Ethernet AVB network allowed for real-time synchronized audio streaming, audio device interoperability, distributed endpoint processing and simple audio routing schemes.
- Full Text:
A formative intervention for developing Learner Representative Council (LRC) voice and leadership in a newly established school in Namibia
- Authors: Amadhila, Linda
- Date: 2018
- Subjects: School management and organization -- Namibia , Educational leadership -- Namibia , Education, Secondary -- Namibia , Student government -- Namibia , Student participation in administration -- Namibia
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/61744 , vital:28054
- Description: In Namibian schools, learner voice and leadership are being promoted through the policy document entitled the Education Act 16 of2001 which provides an opportunity to establish Learner Representative Councils (LRCs) in secondary schools. However, recent studies have found that this body of learner leaders do not function all that effectively and sometimes exist for the sake of adhering to the policy. This prompted me to conduct an activity theoretical interventionist case- study within the critical paradigm, to develop LRC voice and leadership in a newly established Namibian school. Framed by Cultural Historical Activity Theory, the study was divided into two phases to answer the over-arching question: How can LRC voice and leadership be developed in a school? Phase one was largely interpretive, the contextual profiling phase, where document analysis, individual interviews, questionnaires and observations were used to generate data to answer the following research sub-questions: How is learner leadership understood in the school? What leadership development opportunities for the LRC currently exist in the school? What underlying factors constrain the development of LRC voice and leadership in the newly established school? Phase two of the study was the expansive learning phase, which consisted of three intervention workshops. The Change Laboratory method and a focus group interview were used to generate data in response to the last research sub-question: In what ways can LRC participation in a Change Laboratory process contribute to their leadership development? Data generated were inductively and deductively analysed, using the activity theoretical principles of contradictions and double stimulation. Data revealed that learner leadership was largely understood as managerial roles carried out by the LRC in the school. Unlike many schools in Namibia, this case-study school offered numerous leadership development opportunities for the LRC. The community networking events such as: School Exchange Programmes, Town Council breakfast and Junior Regional Council, were opportunities offered to the LRC to solicit information, exchange ideas and discuss matters of common interest with the LRCs of the fully established schools. However, there were a number of challenges that constrained LRC voice and leadership development, the major one being the fact that this was a newly established school. Of significance was that LRC participation in the Change Laboratory process contributed positively to the development of voice and leadership in learners. During this Change Laboratory process, the LRC developed a new artefact - the vision and mission statement of the school - this signified that the learners expansively transformed the object of their activity. Recommendations emerging out of the study included that the School Management Team see the ‘newly established’ status of the school as an opportunity for development, rather than a limitation, and therefore invite the LRC to participate in the different leadership practices as the school becomes established. A significant recommendation for school leadership research is to use the third generation of CHAT to expand the unit of analysis, in order to understand the leadership relations and power dynamics between multiple activity systems in schools as complex organisations.
- Full Text:
- Authors: Amadhila, Linda
- Date: 2018
- Subjects: School management and organization -- Namibia , Educational leadership -- Namibia , Education, Secondary -- Namibia , Student government -- Namibia , Student participation in administration -- Namibia
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/61744 , vital:28054
- Description: In Namibian schools, learner voice and leadership are being promoted through the policy document entitled the Education Act 16 of2001 which provides an opportunity to establish Learner Representative Councils (LRCs) in secondary schools. However, recent studies have found that this body of learner leaders do not function all that effectively and sometimes exist for the sake of adhering to the policy. This prompted me to conduct an activity theoretical interventionist case- study within the critical paradigm, to develop LRC voice and leadership in a newly established Namibian school. Framed by Cultural Historical Activity Theory, the study was divided into two phases to answer the over-arching question: How can LRC voice and leadership be developed in a school? Phase one was largely interpretive, the contextual profiling phase, where document analysis, individual interviews, questionnaires and observations were used to generate data to answer the following research sub-questions: How is learner leadership understood in the school? What leadership development opportunities for the LRC currently exist in the school? What underlying factors constrain the development of LRC voice and leadership in the newly established school? Phase two of the study was the expansive learning phase, which consisted of three intervention workshops. The Change Laboratory method and a focus group interview were used to generate data in response to the last research sub-question: In what ways can LRC participation in a Change Laboratory process contribute to their leadership development? Data generated were inductively and deductively analysed, using the activity theoretical principles of contradictions and double stimulation. Data revealed that learner leadership was largely understood as managerial roles carried out by the LRC in the school. Unlike many schools in Namibia, this case-study school offered numerous leadership development opportunities for the LRC. The community networking events such as: School Exchange Programmes, Town Council breakfast and Junior Regional Council, were opportunities offered to the LRC to solicit information, exchange ideas and discuss matters of common interest with the LRCs of the fully established schools. However, there were a number of challenges that constrained LRC voice and leadership development, the major one being the fact that this was a newly established school. Of significance was that LRC participation in the Change Laboratory process contributed positively to the development of voice and leadership in learners. During this Change Laboratory process, the LRC developed a new artefact - the vision and mission statement of the school - this signified that the learners expansively transformed the object of their activity. Recommendations emerging out of the study included that the School Management Team see the ‘newly established’ status of the school as an opportunity for development, rather than a limitation, and therefore invite the LRC to participate in the different leadership practices as the school becomes established. A significant recommendation for school leadership research is to use the third generation of CHAT to expand the unit of analysis, in order to understand the leadership relations and power dynamics between multiple activity systems in schools as complex organisations.
- Full Text:
A framework for malicious host fingerprinting using distributed network sensors
- Authors: Hunter, Samuel Oswald
- Date: 2018
- Subjects: Computer networks -- Security measures , Malware (Computer software) , Multisensor data fusion , Distributed Sensor Networks , Automated Reconnaissance Framework , Latency Based Multilateration
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/60653 , vital:27811
- Description: Numerous software agents exist and are responsible for increasing volumes of malicious traffic that is observed on the Internet today. From a technical perspective the existing techniques for monitoring malicious agents and traffic were not developed to allow for the interrogation of the source of malicious traffic. This interrogation or reconnaissance would be considered active analysis as opposed to existing, mostly passive analysis. Unlike passive analysis, the active techniques are time-sensitive and their results become increasingly inaccurate as time delta between observation and interrogation increases. In addition to this, some studies had shown that the geographic separation of hosts on the Internet have resulted in pockets of different malicious agents and traffic targeting victims. As such it would be important to perform any kind of data collection over various source and in distributed IP address space. The data gathering and exposure capabilities of sensors such as honeypots and network telescopes were extended through the development of near-realtime Distributed Sensor Network modules that allowed for the near-realtime analysis of malicious traffic from distributed, heterogeneous monitoring sensors. In order to utilise the data exposed by the near-realtime Distributed Sensor Network modules an Automated Reconnaissance Framework was created, this framework was tasked with active and passive information collection and analysis of data in near-realtime and was designed from an adapted Multi Sensor Data Fusion model. The hypothesis was made that if sufficiently different characteristics of a host could be identified; combined they could act as a unique fingerprint for that host, potentially allowing for the re-identification of that host, even if its IP address had changed. To this end the concept of Latency Based Multilateration was introduced, acting as an additional metric for remote host fingerprinting. The vast amount of information gathered by the AR-Framework required the development of visualisation tools which could illustrate this data in near-realtime and also provided various degrees of interaction to accommodate human interpretation of such data. Ultimately the data collected through the application of the near-realtime Distributed Sensor Network and AR-Framework provided a unique perspective of a malicious host demographic. Allowing for new correlations to be drawn between attributes such as common open ports and operating systems, location, and inferred intent of these malicious hosts. The result of which expands our current understanding of malicious hosts on the Internet and enables further research in the area.
- Full Text:
- Authors: Hunter, Samuel Oswald
- Date: 2018
- Subjects: Computer networks -- Security measures , Malware (Computer software) , Multisensor data fusion , Distributed Sensor Networks , Automated Reconnaissance Framework , Latency Based Multilateration
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/60653 , vital:27811
- Description: Numerous software agents exist and are responsible for increasing volumes of malicious traffic that is observed on the Internet today. From a technical perspective the existing techniques for monitoring malicious agents and traffic were not developed to allow for the interrogation of the source of malicious traffic. This interrogation or reconnaissance would be considered active analysis as opposed to existing, mostly passive analysis. Unlike passive analysis, the active techniques are time-sensitive and their results become increasingly inaccurate as time delta between observation and interrogation increases. In addition to this, some studies had shown that the geographic separation of hosts on the Internet have resulted in pockets of different malicious agents and traffic targeting victims. As such it would be important to perform any kind of data collection over various source and in distributed IP address space. The data gathering and exposure capabilities of sensors such as honeypots and network telescopes were extended through the development of near-realtime Distributed Sensor Network modules that allowed for the near-realtime analysis of malicious traffic from distributed, heterogeneous monitoring sensors. In order to utilise the data exposed by the near-realtime Distributed Sensor Network modules an Automated Reconnaissance Framework was created, this framework was tasked with active and passive information collection and analysis of data in near-realtime and was designed from an adapted Multi Sensor Data Fusion model. The hypothesis was made that if sufficiently different characteristics of a host could be identified; combined they could act as a unique fingerprint for that host, potentially allowing for the re-identification of that host, even if its IP address had changed. To this end the concept of Latency Based Multilateration was introduced, acting as an additional metric for remote host fingerprinting. The vast amount of information gathered by the AR-Framework required the development of visualisation tools which could illustrate this data in near-realtime and also provided various degrees of interaction to accommodate human interpretation of such data. Ultimately the data collected through the application of the near-realtime Distributed Sensor Network and AR-Framework provided a unique perspective of a malicious host demographic. Allowing for new correlations to be drawn between attributes such as common open ports and operating systems, location, and inferred intent of these malicious hosts. The result of which expands our current understanding of malicious hosts on the Internet and enables further research in the area.
- Full Text:
A gender based analysis of the Amalima Programme in empowering married women within households in rural Gwanda, Zimbabwe
- Authors: Sibanda, Patience
- Date: 2018
- Subjects: Non-governmental organizations Zimbabwe Matabeleland South Province , Power (Social sciences) Zimbabwe Matabeleland South Province , Women Zimbabwe Social conditions , Women's rights Zimbabwe , Patriarchy Zimbabwe Matabeleland South Province
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/63682 , vital:28470
- Description: Non-Governmental Organisations (NGOs) have occupied a prominent role in the socio-economic development of rural areas of Zimbabwe since the time of the country’s independence in 1980, including a focus on improving the conditions and status of women in communal areas. These NGOs adopt a participatory methodology in their development programmes and projects, as they try to ensure that the active participation of women in rural development facilitates women’s access to resources and the realisation of their rights. These initiatives are important given the pronounced system of patriarchy which exists in communal areas. In the context of local patriarchies, NGOs also often claim that they empower women. This thesis focuses on the work of one particular NGO programme, namely the Amalima programme, with a particular focus on three wards in the communal areas in Gwanda, Zimbabwe. From a gendered perspective concerned with questions of women’s empowerment, the main objective of the thesis is to provide a critical analysis of the Amalima programme with particular reference to married women in Gwanda. Based on original fieldwork (including interviews with men, women and NGO practitioners), the thesis concludes that the outcomes of the Amalima programme in empowering married women in Gwanda are uneven and that, overall, the local system of patriarchy (including at household level) remains largely intact.
- Full Text:
- Authors: Sibanda, Patience
- Date: 2018
- Subjects: Non-governmental organizations Zimbabwe Matabeleland South Province , Power (Social sciences) Zimbabwe Matabeleland South Province , Women Zimbabwe Social conditions , Women's rights Zimbabwe , Patriarchy Zimbabwe Matabeleland South Province
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/63682 , vital:28470
- Description: Non-Governmental Organisations (NGOs) have occupied a prominent role in the socio-economic development of rural areas of Zimbabwe since the time of the country’s independence in 1980, including a focus on improving the conditions and status of women in communal areas. These NGOs adopt a participatory methodology in their development programmes and projects, as they try to ensure that the active participation of women in rural development facilitates women’s access to resources and the realisation of their rights. These initiatives are important given the pronounced system of patriarchy which exists in communal areas. In the context of local patriarchies, NGOs also often claim that they empower women. This thesis focuses on the work of one particular NGO programme, namely the Amalima programme, with a particular focus on three wards in the communal areas in Gwanda, Zimbabwe. From a gendered perspective concerned with questions of women’s empowerment, the main objective of the thesis is to provide a critical analysis of the Amalima programme with particular reference to married women in Gwanda. Based on original fieldwork (including interviews with men, women and NGO practitioners), the thesis concludes that the outcomes of the Amalima programme in empowering married women in Gwanda are uneven and that, overall, the local system of patriarchy (including at household level) remains largely intact.
- Full Text:
A gold–chitosan composite with low symmetry zinc phthalocyanine for enhanced singlet oxygen generation and improved photodynamic therapy activity
- Dube, Edith, Oluwole, David O, Prinsloo, Earl, Nyokong, Tebello
- Authors: Dube, Edith , Oluwole, David O , Prinsloo, Earl , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/233397 , vital:50087 , xlink:href="https://doi.org/10.1039/C8NJ00801A"
- Description: Novel zinc(II) 3-(4-((3,17,23-tris(4-(benzo[d]thiazol-2-yl)phenoxy)phthalocyanine-9-yl)oxy)phenyl)propanoic acid (complex 3) was synthesised. Complex 3 was subsequently reacted with gold nanoparticles (AuNPs), chitosan (CT) and a gold–chitosan (AuCT) hybrid to form 3-AuNPs, 3-CT and 3-AuCT, respectively. The conjugates afforded a decrease in fluorescence quantum yield with a corresponding increase in the triplet and singlet quantum yields compared to complex 3. The in vitro dark cytotoxicity and photodynamic therapy activity (PDT) of complex 3 and 3-AuCT composites were investigated against epithelial breast cancer cells (MCF-7) with both the samples showing minimum dark cytotoxicity. They both accounted for a cell viability of ≥90% at a concentration of ≤59.2 μg mL−1. 3-AuCT showed better PDT activity (compared to 3 alone) with less than 50% viable cells at a concentration of ≥29.6 μg mL−1 making it potentially applicable for PDT. On the other hand, AuCT displayed some activity against cancer cells, probably due to photothermal activity since gold is a light absorber, however it had more than 50% viable cells at a concentration of ≤59.2 μg mL−1.
- Full Text:
- Authors: Dube, Edith , Oluwole, David O , Prinsloo, Earl , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/233397 , vital:50087 , xlink:href="https://doi.org/10.1039/C8NJ00801A"
- Description: Novel zinc(II) 3-(4-((3,17,23-tris(4-(benzo[d]thiazol-2-yl)phenoxy)phthalocyanine-9-yl)oxy)phenyl)propanoic acid (complex 3) was synthesised. Complex 3 was subsequently reacted with gold nanoparticles (AuNPs), chitosan (CT) and a gold–chitosan (AuCT) hybrid to form 3-AuNPs, 3-CT and 3-AuCT, respectively. The conjugates afforded a decrease in fluorescence quantum yield with a corresponding increase in the triplet and singlet quantum yields compared to complex 3. The in vitro dark cytotoxicity and photodynamic therapy activity (PDT) of complex 3 and 3-AuCT composites were investigated against epithelial breast cancer cells (MCF-7) with both the samples showing minimum dark cytotoxicity. They both accounted for a cell viability of ≥90% at a concentration of ≤59.2 μg mL−1. 3-AuCT showed better PDT activity (compared to 3 alone) with less than 50% viable cells at a concentration of ≥29.6 μg mL−1 making it potentially applicable for PDT. On the other hand, AuCT displayed some activity against cancer cells, probably due to photothermal activity since gold is a light absorber, however it had more than 50% viable cells at a concentration of ≤59.2 μg mL−1.
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A medicinal chemistry study in nitrogen containing heterocycles
- Authors: Lunga, Mayibongwe Junior
- Date: 2018
- Subjects: Indole , Tetrazoles , Antimalarials , Heat shock proteins , Plasmodium falciparum
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/63521 , vital:28430
- Description: Heterocyclic structures have found extensive utility in the field of medicinal chemistry, as prominent regions of pharmacophores resulting in numerous drug treatments for many diseases. Accordingly, in this project we explored the respective antimalarial and anticancer activity exhibited by compounds featuring nitrogen containing indole and tetrazole heterocycles respectively. This thesis therefore comprises of two distinct parts. Part 1. Following the development of resistance towards traditional antimalarial therapy such as chloroquine and emerging resistance towards artemisinin combination therapies, the WHO reported the urgent need for new, effective drugs and identification of new drug targets to combat the Plasmodium falciparum parasite. In 2015 the parasite was the cause of 429 000 deaths, the majority occurring in the sub-Saharan region of Africa. This highlights the failing effectiveness of vector control strategies, reiterating the need to develop alternative control and treatment strategies. In response to this need we wanted to expand and further describe the SAR of the indole based series, indolyl-3-ethanone-α- thioethers, previously synthesized in our laboratory. These compounds were found to exhibit antimalarial activity with compounds 2.26 and 2.27 exhibiting activity against P. falciparum 3D7 in the nanomolar range. Based on these compounds we synthesized compounds 3.21 and 3.24 – 3.32 following a three step reaction pathway. Our results in this study, indicate that compound 3.28, a pnitrothiophenol analogue of 2.27 was the most active of the compounds we synthesized and furthermore was superior in activity against Plasmodium compared to 2.27. This result indicated that the presence of p-NO2 is important in enhancing anti-plasmodial activity. Comparing compounds 3.25 and 3.26 with an oxygen on the ether bridge to compounds 3.29 and 3.30 with a sulfur, we observed an increase in hydrophilicity coupled to a decrease in anti-plasmodial activity in the compounds, thus, highlighting the importance of sulfur for enhanced activity. Furthermore, we investigated bioisosteric replacement of the 5-chloro substituent present in hit compounds 2.27 and 3.28, with an electron withdrawing nitrile (3.27) and electron donating methyl (3.29) and methoxy (3.31) substituents. These substituents decreased anti-plasmodial activity, confirming that a chlorine substituent is optimal for biological activity. This study furthered our understanding of the SAR of indolyl-3-ethanone-α- thioethers for the development of potent anti-plasmodial lead compounds. Part 2. Triple negative breast cancer (TNBC), which disproportionately affects women of sub-Saharan Africa, is unresponsive to hormone-based therapies. This emergence presents a population of patients devoid of effective drug treatment, signaling the urgent need to develop new effective therapies with novel drug targets. Therefore, we identified our target in TNBC cells as the protein-protein interaction between the co-chaperones HOP and HSP90. We reasoned that a disruption of this interaction would ultimately result in cancer cell death via the degradation of essential oncogenic client proteins. Following a fragment screening campaign, which identified several acid and tetrazole containing hits (4.56 – 4.58) which bound to HOP, with low anticancer activity, we sought to develop synthetic methodology to elaborate our fragment hits synthesizing tetrazole containing fragments to target TNBC cell lines. We therefore proceeded to synthesize a range of multi substituted fragments (4.59 – 4.63), utilizing a nitrile (4.66) to access tetrazoles via 1,3-cycloaddition and an acid by nitrile hydrolysis. We successfully synthesized the tetrazole and acid fragments which are currently undergoing characterization for activity against TNBC. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2018
- Full Text:
- Authors: Lunga, Mayibongwe Junior
- Date: 2018
- Subjects: Indole , Tetrazoles , Antimalarials , Heat shock proteins , Plasmodium falciparum
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/63521 , vital:28430
- Description: Heterocyclic structures have found extensive utility in the field of medicinal chemistry, as prominent regions of pharmacophores resulting in numerous drug treatments for many diseases. Accordingly, in this project we explored the respective antimalarial and anticancer activity exhibited by compounds featuring nitrogen containing indole and tetrazole heterocycles respectively. This thesis therefore comprises of two distinct parts. Part 1. Following the development of resistance towards traditional antimalarial therapy such as chloroquine and emerging resistance towards artemisinin combination therapies, the WHO reported the urgent need for new, effective drugs and identification of new drug targets to combat the Plasmodium falciparum parasite. In 2015 the parasite was the cause of 429 000 deaths, the majority occurring in the sub-Saharan region of Africa. This highlights the failing effectiveness of vector control strategies, reiterating the need to develop alternative control and treatment strategies. In response to this need we wanted to expand and further describe the SAR of the indole based series, indolyl-3-ethanone-α- thioethers, previously synthesized in our laboratory. These compounds were found to exhibit antimalarial activity with compounds 2.26 and 2.27 exhibiting activity against P. falciparum 3D7 in the nanomolar range. Based on these compounds we synthesized compounds 3.21 and 3.24 – 3.32 following a three step reaction pathway. Our results in this study, indicate that compound 3.28, a pnitrothiophenol analogue of 2.27 was the most active of the compounds we synthesized and furthermore was superior in activity against Plasmodium compared to 2.27. This result indicated that the presence of p-NO2 is important in enhancing anti-plasmodial activity. Comparing compounds 3.25 and 3.26 with an oxygen on the ether bridge to compounds 3.29 and 3.30 with a sulfur, we observed an increase in hydrophilicity coupled to a decrease in anti-plasmodial activity in the compounds, thus, highlighting the importance of sulfur for enhanced activity. Furthermore, we investigated bioisosteric replacement of the 5-chloro substituent present in hit compounds 2.27 and 3.28, with an electron withdrawing nitrile (3.27) and electron donating methyl (3.29) and methoxy (3.31) substituents. These substituents decreased anti-plasmodial activity, confirming that a chlorine substituent is optimal for biological activity. This study furthered our understanding of the SAR of indolyl-3-ethanone-α- thioethers for the development of potent anti-plasmodial lead compounds. Part 2. Triple negative breast cancer (TNBC), which disproportionately affects women of sub-Saharan Africa, is unresponsive to hormone-based therapies. This emergence presents a population of patients devoid of effective drug treatment, signaling the urgent need to develop new effective therapies with novel drug targets. Therefore, we identified our target in TNBC cells as the protein-protein interaction between the co-chaperones HOP and HSP90. We reasoned that a disruption of this interaction would ultimately result in cancer cell death via the degradation of essential oncogenic client proteins. Following a fragment screening campaign, which identified several acid and tetrazole containing hits (4.56 – 4.58) which bound to HOP, with low anticancer activity, we sought to develop synthetic methodology to elaborate our fragment hits synthesizing tetrazole containing fragments to target TNBC cell lines. We therefore proceeded to synthesize a range of multi substituted fragments (4.59 – 4.63), utilizing a nitrile (4.66) to access tetrazoles via 1,3-cycloaddition and an acid by nitrile hydrolysis. We successfully synthesized the tetrazole and acid fragments which are currently undergoing characterization for activity against TNBC. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2018
- Full Text:
A micro-ethnography: exploring relations between Somali and South African traders in Clarehill, Cape Town
- Authors: Solomon, Kelly Michelle
- Date: 2018
- Subjects: Immigrants South Africa , Immigrants Social conditions , Xenophobia South Africa , Social capital (Sociology) South Africa , Somalis Migrations , Identity (Philosophical concept) , South Africa Race relations
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/61277 , vital:27999 , https://doi.org/10.21504/10962/61277
- Description: Xenophobia has become a dominant narrative in contemporary South Africa. In this thesis, I hone in on a micro, informal economic market that functions cohesively and convivially with both South African and Somali transmigrant traders in it. Religion is one of the key ways through which migrants are able to access social networks and social capital. Islam, the dominant practised religion in the market, thus forms a foundation for strong, emotionally supportive, caring relationships between Somali transmigrants and South Africans The relationships between South African traders and Somali transmigrants are mutually constitutive, as they lean on one another for stability during a time that is unstable for both groups. The closeness of their relationships is evident through the way in which they tease and joke with one another, and the many ways in which they offer intangible support to each other. This thesis illustrates that despite the dominant xenophobic narrative, a close social kinship is formed in the Roelof Street market between South Africans and Somali transmigrants.
- Full Text:
- Authors: Solomon, Kelly Michelle
- Date: 2018
- Subjects: Immigrants South Africa , Immigrants Social conditions , Xenophobia South Africa , Social capital (Sociology) South Africa , Somalis Migrations , Identity (Philosophical concept) , South Africa Race relations
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/61277 , vital:27999 , https://doi.org/10.21504/10962/61277
- Description: Xenophobia has become a dominant narrative in contemporary South Africa. In this thesis, I hone in on a micro, informal economic market that functions cohesively and convivially with both South African and Somali transmigrant traders in it. Religion is one of the key ways through which migrants are able to access social networks and social capital. Islam, the dominant practised religion in the market, thus forms a foundation for strong, emotionally supportive, caring relationships between Somali transmigrants and South Africans The relationships between South African traders and Somali transmigrants are mutually constitutive, as they lean on one another for stability during a time that is unstable for both groups. The closeness of their relationships is evident through the way in which they tease and joke with one another, and the many ways in which they offer intangible support to each other. This thesis illustrates that despite the dominant xenophobic narrative, a close social kinship is formed in the Roelof Street market between South Africans and Somali transmigrants.
- Full Text:
A mineral systems approach to the development of structural targeting criteria for orogenic gold deposits in the Asankrangwa gold belt of the Kumasi Basin, South-west Ghana
- Authors: Gelber, Benjamin D J
- Date: 2018
- Subjects: Gold ores -- Geology -- Ghana -- Kumasi , Gold mines and mining -- Ghana -- Kumasi , Asankrangwa (Ghana) , Geodynamics -- Ghana -- Kumasi , Prospecting -- Geophysical methods , Orogenic belts -- Ghana -- Kumasi
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/63143 , vital:28367
- Description: The Kumasi Basin in South-west Ghana lies at the centre of the best-endowed Paleoproterozoic gold province in the world. The Kumasi Basin and margins of the adjacent volcanic belts are host to six world class gold camps: (1) 62 Moz Obuasi camp, (2) 22 Moz Prestea-Bogoso camp, (3) 11 Moz Asanko Gold Mine camp, (4) 9 Moz Edikan camp, (5) 7 Moz Bibiani camp, (6) 5 Moz Chirano camp, as well as several additional minor gold camps and many more prospects. Cumulatively these camps account for>116 Moz of endowment and contribute to making south-west Ghana the greatest Paleoproterozoic gold province in the world. Gold deposits in the Kumasi Basin are shear zone hosted and mineralisation ranges from disseminated to massive sulphide refractory deposits, to free milling quartz vein style deposits. Structural relationships and age dating indicate that most deposits are genetically related and were formed during a single episode of gold mineralisation during the D4 NNW-SSE crustal shortening deformation event of the Eburnean Orogeny (2125 – 1980 Ma). The understanding of structural controls on mineralisation is critical for exploration success as it allows exploration to focus on areas where these structural controls exist. This study uses a mineral systems approach to understand the relationship between the geodynamic history and structural controls on gold mineralisation in the Kumasi Basin at various scales, and define targeting criteria which can be applied for the purpose of developing predictive exploration models for making new discoveries in the Asanko Gold Mine camp located in the Asankrangwa Belt. The study used a quantitative analysis to establish residual endowment potential in the Asankrangwa Belt, providing the basis for a business model and resulting exploration strategy. Once established, a Fry autocorrelation analysis was applied to identify trends in deposit and camp spatial distribution to which critical geological processes were ascribed. Observed trends were mapped from multi-scale geophysical data sets and through interpretation of existing geophysical structure models, and structural criteria for targeting orogenic gold deposits at the regional and camp scales were developed. Results show that different structural controls on mineralisation act at the regional and camp scale. At the regional scale the distribution of gold camps was found to be controlled by fundamental N-S and NW-SE basement structures with gold camps forming where they intersect NE-SW first and second order structural corridors. At the Asanko Gold Mine camp scale, deposit distribution was found to be related to the intersection between major second order D3 NE-SW shear zones, minor third order D4 NNE-SSW brittle faults, and cryptic NW-SE upward propagating basement structures. In addition to these structural criteria, deposits in the Asanko Gold Mine camp were found to be aligned along a NNE-SSW lineament caused by the interaction between the N-S basement structure and the NE-SW trending Asankrangwa Belt shear corridor.
- Full Text:
- Authors: Gelber, Benjamin D J
- Date: 2018
- Subjects: Gold ores -- Geology -- Ghana -- Kumasi , Gold mines and mining -- Ghana -- Kumasi , Asankrangwa (Ghana) , Geodynamics -- Ghana -- Kumasi , Prospecting -- Geophysical methods , Orogenic belts -- Ghana -- Kumasi
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/63143 , vital:28367
- Description: The Kumasi Basin in South-west Ghana lies at the centre of the best-endowed Paleoproterozoic gold province in the world. The Kumasi Basin and margins of the adjacent volcanic belts are host to six world class gold camps: (1) 62 Moz Obuasi camp, (2) 22 Moz Prestea-Bogoso camp, (3) 11 Moz Asanko Gold Mine camp, (4) 9 Moz Edikan camp, (5) 7 Moz Bibiani camp, (6) 5 Moz Chirano camp, as well as several additional minor gold camps and many more prospects. Cumulatively these camps account for>116 Moz of endowment and contribute to making south-west Ghana the greatest Paleoproterozoic gold province in the world. Gold deposits in the Kumasi Basin are shear zone hosted and mineralisation ranges from disseminated to massive sulphide refractory deposits, to free milling quartz vein style deposits. Structural relationships and age dating indicate that most deposits are genetically related and were formed during a single episode of gold mineralisation during the D4 NNW-SSE crustal shortening deformation event of the Eburnean Orogeny (2125 – 1980 Ma). The understanding of structural controls on mineralisation is critical for exploration success as it allows exploration to focus on areas where these structural controls exist. This study uses a mineral systems approach to understand the relationship between the geodynamic history and structural controls on gold mineralisation in the Kumasi Basin at various scales, and define targeting criteria which can be applied for the purpose of developing predictive exploration models for making new discoveries in the Asanko Gold Mine camp located in the Asankrangwa Belt. The study used a quantitative analysis to establish residual endowment potential in the Asankrangwa Belt, providing the basis for a business model and resulting exploration strategy. Once established, a Fry autocorrelation analysis was applied to identify trends in deposit and camp spatial distribution to which critical geological processes were ascribed. Observed trends were mapped from multi-scale geophysical data sets and through interpretation of existing geophysical structure models, and structural criteria for targeting orogenic gold deposits at the regional and camp scales were developed. Results show that different structural controls on mineralisation act at the regional and camp scale. At the regional scale the distribution of gold camps was found to be controlled by fundamental N-S and NW-SE basement structures with gold camps forming where they intersect NE-SW first and second order structural corridors. At the Asanko Gold Mine camp scale, deposit distribution was found to be related to the intersection between major second order D3 NE-SW shear zones, minor third order D4 NNE-SSW brittle faults, and cryptic NW-SE upward propagating basement structures. In addition to these structural criteria, deposits in the Asanko Gold Mine camp were found to be aligned along a NNE-SSW lineament caused by the interaction between the N-S basement structure and the NE-SW trending Asankrangwa Belt shear corridor.
- Full Text:
A mineralogical, geochemical and metallogenic study of unusual Mn/Na/Ba assemblages at the footwall of conglomeratic iron-ore at farm Langverwacht, Northern Cape Province of South Africa
- Authors: Bursey, James Rodney
- Date: 2018
- Subjects: Iron ores -- Geology -- South Africa -- Northern Cape , Conglomerate -- South Africa -- Northern Cape , Petrology -- South Africa -- Northern Cape , Manganese -- South Africa -- Northern Cape , Sodium -- South Africa -- Northern Cape , Barium -- South Africa -- Northern Cape
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/62516 , vital:28201
- Description: The Postmasburg Manganese Field (PMF), located in the Northern Cape province of South Africa, plays host to significant deposits of iron and manganese that have been utilized since their discovery in 1922 by Captain L.T. Shone. Further afield, lies the massive high-grade manganese deposit of the Kalahari Manganese Field (KMF), which drew attention away from the PMF after its discovery. These deposits are not limited to iron and manganese ore, but contain significant assemblages of alkali-rich rocks - which is the focus of this study. The existence of alkali-rich assemblages beneath conglomeratic iron-ore on farm Langwervacht, has come under investigation in this study, and in particular, the enrichment of these rocks in Ba, Na and Mn. Petrographic analysis of the clast-supported conglomerate unit (ore-zone), has uncovered the presence of vugs (up to 8mm across) which contain barite, K-feldspar and fluorapatite. In addition to this, the ore-zone of one of the three boreholes contains late carbonate veins (kutnohorite), which travel along Fe-clast boundaries, and exploit clast-fractures and areas of weakness. Further down, within the ‘enriched-zone’ of alkalis, the mineralogy is more diverse - containing elevated concentrations of Ba, Na and Mn. Seventeen distinct minerals containing these three key elements have been identified - along with one solid-solution series in the form of hollandite-coronadite. The existence of minerals such as natrolite, aegirine, albite, banalsite, barite, serandite, celsian and hollandite-coronadite are indicative of hydrothermal activity having influenced these rocks. Bulk-geochemistry was used to compare the major and trace elements of each borehole and the associated units. Both the trace elements and the REE’s from the ore-zone are enriched by an average of 5-10x relative to the BIF standard used - which immediately suggests an influx of elements. Compared to PAAS (Post Archaean Australian Shales), the ore-zone REE’s are slightly depleted, but more importantly the profiles are very similar to that of the Mapedi shales achieved in previous studies. This result points towards a strong shale influence in the ore-zone protolith. Expectedly, many of the enriched-zone trace elements and REE’s show far greater enrichment than what is observed in the ore-zone. Trace and Rare Earth Element profiles between the ore-zone and the enriched-zone are, however, generally correlative, with profiles reflecting similar enrichments and depletions for a given element - even within different rock units. This suggests that the hydrothermal fluid has moved in a general upward direction, reacting with host-rock units, and relinquishing elements carried in solution - wherever conditions have been favourable for the accommodation of these elements. This study has shed light on the relationship between the ore-zone and the enriched-zone, and results suggest that the process of alkali enrichment is not directly related to the process of upgrading of the iron ores. This is due to the extent of the alkali-enrichment below the ore-zone, as well as enrichment factors in some trace elements being superior to that of Fe2O3 in the ore- zone. Hence, both of these zones have both been affected by a later hydrothermal fluid. The source of the fluid is likely a mature basinal brine, of oxidized, alkaline nature - which leached elements (Ba, K, Na, Pb, Ca) from older rocks, and carried them in solution. On a local-scale, this fluid has exploited areas of weakness in the form of fractures, less consolidated conglomeratic material and crosscutting veins. Manganese and iron has been remobilized on a local scale - producing secondary textures and partitioning into phases such as Mn-rich calcite and serandite. Comparisons to other studies in the PMF and KMF have revealed very similar alkali-rich assemblages, bearing many of the same minerals observed in this study - even within more manganiferous deposits. These findings have led to suggestions of a possible regional-scale hydrothermal overprint, which may have imparted a similar geochemical signal over the entire region - with the assistance of faults and unconformities. Of course, proving this is no mean feat, but current work on the source of barium in barite, using Sr isotopes from samples across the region may shed light on the source of at least one key element of these deposits.
- Full Text:
- Authors: Bursey, James Rodney
- Date: 2018
- Subjects: Iron ores -- Geology -- South Africa -- Northern Cape , Conglomerate -- South Africa -- Northern Cape , Petrology -- South Africa -- Northern Cape , Manganese -- South Africa -- Northern Cape , Sodium -- South Africa -- Northern Cape , Barium -- South Africa -- Northern Cape
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/62516 , vital:28201
- Description: The Postmasburg Manganese Field (PMF), located in the Northern Cape province of South Africa, plays host to significant deposits of iron and manganese that have been utilized since their discovery in 1922 by Captain L.T. Shone. Further afield, lies the massive high-grade manganese deposit of the Kalahari Manganese Field (KMF), which drew attention away from the PMF after its discovery. These deposits are not limited to iron and manganese ore, but contain significant assemblages of alkali-rich rocks - which is the focus of this study. The existence of alkali-rich assemblages beneath conglomeratic iron-ore on farm Langwervacht, has come under investigation in this study, and in particular, the enrichment of these rocks in Ba, Na and Mn. Petrographic analysis of the clast-supported conglomerate unit (ore-zone), has uncovered the presence of vugs (up to 8mm across) which contain barite, K-feldspar and fluorapatite. In addition to this, the ore-zone of one of the three boreholes contains late carbonate veins (kutnohorite), which travel along Fe-clast boundaries, and exploit clast-fractures and areas of weakness. Further down, within the ‘enriched-zone’ of alkalis, the mineralogy is more diverse - containing elevated concentrations of Ba, Na and Mn. Seventeen distinct minerals containing these three key elements have been identified - along with one solid-solution series in the form of hollandite-coronadite. The existence of minerals such as natrolite, aegirine, albite, banalsite, barite, serandite, celsian and hollandite-coronadite are indicative of hydrothermal activity having influenced these rocks. Bulk-geochemistry was used to compare the major and trace elements of each borehole and the associated units. Both the trace elements and the REE’s from the ore-zone are enriched by an average of 5-10x relative to the BIF standard used - which immediately suggests an influx of elements. Compared to PAAS (Post Archaean Australian Shales), the ore-zone REE’s are slightly depleted, but more importantly the profiles are very similar to that of the Mapedi shales achieved in previous studies. This result points towards a strong shale influence in the ore-zone protolith. Expectedly, many of the enriched-zone trace elements and REE’s show far greater enrichment than what is observed in the ore-zone. Trace and Rare Earth Element profiles between the ore-zone and the enriched-zone are, however, generally correlative, with profiles reflecting similar enrichments and depletions for a given element - even within different rock units. This suggests that the hydrothermal fluid has moved in a general upward direction, reacting with host-rock units, and relinquishing elements carried in solution - wherever conditions have been favourable for the accommodation of these elements. This study has shed light on the relationship between the ore-zone and the enriched-zone, and results suggest that the process of alkali enrichment is not directly related to the process of upgrading of the iron ores. This is due to the extent of the alkali-enrichment below the ore-zone, as well as enrichment factors in some trace elements being superior to that of Fe2O3 in the ore- zone. Hence, both of these zones have both been affected by a later hydrothermal fluid. The source of the fluid is likely a mature basinal brine, of oxidized, alkaline nature - which leached elements (Ba, K, Na, Pb, Ca) from older rocks, and carried them in solution. On a local-scale, this fluid has exploited areas of weakness in the form of fractures, less consolidated conglomeratic material and crosscutting veins. Manganese and iron has been remobilized on a local scale - producing secondary textures and partitioning into phases such as Mn-rich calcite and serandite. Comparisons to other studies in the PMF and KMF have revealed very similar alkali-rich assemblages, bearing many of the same minerals observed in this study - even within more manganiferous deposits. These findings have led to suggestions of a possible regional-scale hydrothermal overprint, which may have imparted a similar geochemical signal over the entire region - with the assistance of faults and unconformities. Of course, proving this is no mean feat, but current work on the source of barium in barite, using Sr isotopes from samples across the region may shed light on the source of at least one key element of these deposits.
- Full Text:
A missing link in the estuarine nitrogen cycle?: coupled nitrification-denitrification mediated by suspended particulate matter
- Zhu, Weijing, Wang, Cheng, Hill, Jaclyn M, He, Yangyang, Tao, Bangyi, Mao, Zhihua, Wu, Weixiang
- Authors: Zhu, Weijing , Wang, Cheng , Hill, Jaclyn M , He, Yangyang , Tao, Bangyi , Mao, Zhihua , Wu, Weixiang
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68368 , vital:29244 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-018-20688-4
- Description: In estuarine and coastal ecosystems, the majority of previous studies have considered coupled nitrification-denitrification (CND) processes to be exclusively sediment based, with little focus onsuspended particulate matter (SPM) in the water column. Here, we present evidence of CND processes in the water column of Hangzhou Bay, one of the largest macrotidal embayments in the world.
- Full Text:
- Authors: Zhu, Weijing , Wang, Cheng , Hill, Jaclyn M , He, Yangyang , Tao, Bangyi , Mao, Zhihua , Wu, Weixiang
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68368 , vital:29244 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-018-20688-4
- Description: In estuarine and coastal ecosystems, the majority of previous studies have considered coupled nitrification-denitrification (CND) processes to be exclusively sediment based, with little focus onsuspended particulate matter (SPM) in the water column. Here, we present evidence of CND processes in the water column of Hangzhou Bay, one of the largest macrotidal embayments in the world.
- Full Text:
A molecular phylogeny of the cicadas (Hemiptera: Cicadidae) with a review of tribe and subfamily classification:
- Marshall, David C, Moulds, Max, Hill, Kathy B R, Price, Benjamin W, Wade, Elizabeth J, Owen, Christopher L, Goemans, Geert, Marathe, Kiran, Sarkar, Vivek, Cooley, John R, Sanborn, Allen F, Kunte, Krushnamegh, Villet, Martin H, Simon, Chris
- Authors: Marshall, David C , Moulds, Max , Hill, Kathy B R , Price, Benjamin W , Wade, Elizabeth J , Owen, Christopher L , Goemans, Geert , Marathe, Kiran , Sarkar, Vivek , Cooley, John R , Sanborn, Allen F , Kunte, Krushnamegh , Villet, Martin H , Simon, Chris
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140601 , vital:37902 , DOI: 10.11646/zootaxa.4424.1.1
- Description: A molecular phylogeny and a review of family-group classification are presented for 137 species (ca. 125 genera) of the insect family Cicadidae, the true cicadas, plus two species of hairy cicadas (Tettigarctidae) and two outgroup species from Cercopidae. Five genes, two of them mitochondrial, comprise the 4992 base-pair molecular dataset. Maximum-likelihood and Bayesian phylogenetic results are shown, including analyses to address potential base composition bias. Tettigarcta is confirmed as the sister-clade of the Cicadidae and support is found for three subfamilies identified in an earlier morphological cladistic analysis. A set of paraphyletic deep-level clades formed by African genera are together named as Tettigomyiinae n. stat. Taxonomic reassignments of genera and tribes are made where morphological examination confirms incorrect placements suggested by the molecular tree, and 11 new tribes are defined (Arenopsaltriini n. tribe, Durangonini n. tribe, Katoini n. tribe, Lacetasini n. tribe, Macrotristriini n. tribe, Malagasiini n. tribe, Nelcyndanini n. tribe, Pagiphorini n. tribe, Pictilini n. tribe, Psaltodini n. tribe, and Selymbriini n. tribe). Tribe Tacuini n. syn. is synonymized with Cryptotympanini, and Tryellina n. syn. is synonymized with an expanded Tribe Lamotialnini. Tribe Hyantiini n. syn. is synonymized with Fidicinini. Tribe Sinosenini is transferred to Cicadinae from Cicadettinae, Cicadatrini is moved to Cicadettinae from Cicadinae, and Ydiellini and Tettigomyiini are transferred to Tettigomyiinae n. stat from Cicadettinae. While the subfamily Cicadinae, historically defined by the presence of timbal covers, is weakly supported in the molecular tree, high taxonomic rank is not supported for several earlier clades based on unique morphology associated with sound production.
- Full Text:
- Authors: Marshall, David C , Moulds, Max , Hill, Kathy B R , Price, Benjamin W , Wade, Elizabeth J , Owen, Christopher L , Goemans, Geert , Marathe, Kiran , Sarkar, Vivek , Cooley, John R , Sanborn, Allen F , Kunte, Krushnamegh , Villet, Martin H , Simon, Chris
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140601 , vital:37902 , DOI: 10.11646/zootaxa.4424.1.1
- Description: A molecular phylogeny and a review of family-group classification are presented for 137 species (ca. 125 genera) of the insect family Cicadidae, the true cicadas, plus two species of hairy cicadas (Tettigarctidae) and two outgroup species from Cercopidae. Five genes, two of them mitochondrial, comprise the 4992 base-pair molecular dataset. Maximum-likelihood and Bayesian phylogenetic results are shown, including analyses to address potential base composition bias. Tettigarcta is confirmed as the sister-clade of the Cicadidae and support is found for three subfamilies identified in an earlier morphological cladistic analysis. A set of paraphyletic deep-level clades formed by African genera are together named as Tettigomyiinae n. stat. Taxonomic reassignments of genera and tribes are made where morphological examination confirms incorrect placements suggested by the molecular tree, and 11 new tribes are defined (Arenopsaltriini n. tribe, Durangonini n. tribe, Katoini n. tribe, Lacetasini n. tribe, Macrotristriini n. tribe, Malagasiini n. tribe, Nelcyndanini n. tribe, Pagiphorini n. tribe, Pictilini n. tribe, Psaltodini n. tribe, and Selymbriini n. tribe). Tribe Tacuini n. syn. is synonymized with Cryptotympanini, and Tryellina n. syn. is synonymized with an expanded Tribe Lamotialnini. Tribe Hyantiini n. syn. is synonymized with Fidicinini. Tribe Sinosenini is transferred to Cicadinae from Cicadettinae, Cicadatrini is moved to Cicadettinae from Cicadinae, and Ydiellini and Tettigomyiini are transferred to Tettigomyiinae n. stat from Cicadettinae. While the subfamily Cicadinae, historically defined by the presence of timbal covers, is weakly supported in the molecular tree, high taxonomic rank is not supported for several earlier clades based on unique morphology associated with sound production.
- Full Text:
A narrative study of patients’ illness experiences on antiretroviral treatment
- Authors: Tsope, Lindiwe
- Date: 2018
- Subjects: AIDS (Disease) Social aspects South Africa , HIV infections Social aspects South Africa , Stigma (Social psychology) , Antiretroviral agents , Disclosure of information , Social media in medicine South Africa , Discourse analysis, Narrative
- Language: English
- Type: text , Thesis , Masters , MSocSc
- Identifier: http://hdl.handle.net/10962/63032 , vital:28356
- Description: Eight female respondents, who have publicly disclosed their HIV-positive status on social media, were involved in a semi-structured in-depth interview process. Using the theoretical frameworks of symbolic interactionism and social constructionism, the study explores the effects of antiretroviral treatment on patients’ illness experiences, looking at the personal and social symbolisms and meanings attached to taking antiretrovirals. The study revealed a positive and inspirational aspect of living with HIV/AIDS and especially consuming antiretroviral therapy. It became evident that the knowledge participants had of antiretrovirals before consuming them was misguided and based more on false ‘general knowledge’ among laypersons than actual medical fact. Moreover, the study revealed that there is a social reconstruction of narratives that has taken place in each participant’s life due to consuming antiretrovirals. Publicly disclosing their statuses has also proved to have both negative and positive consequences for the individuals and for society at large. While there is a consensus that participants’ illness experiences are directly affected by antiretroviral treatment, each participant’s narrative is different, yet positive.
- Full Text:
- Authors: Tsope, Lindiwe
- Date: 2018
- Subjects: AIDS (Disease) Social aspects South Africa , HIV infections Social aspects South Africa , Stigma (Social psychology) , Antiretroviral agents , Disclosure of information , Social media in medicine South Africa , Discourse analysis, Narrative
- Language: English
- Type: text , Thesis , Masters , MSocSc
- Identifier: http://hdl.handle.net/10962/63032 , vital:28356
- Description: Eight female respondents, who have publicly disclosed their HIV-positive status on social media, were involved in a semi-structured in-depth interview process. Using the theoretical frameworks of symbolic interactionism and social constructionism, the study explores the effects of antiretroviral treatment on patients’ illness experiences, looking at the personal and social symbolisms and meanings attached to taking antiretrovirals. The study revealed a positive and inspirational aspect of living with HIV/AIDS and especially consuming antiretroviral therapy. It became evident that the knowledge participants had of antiretrovirals before consuming them was misguided and based more on false ‘general knowledge’ among laypersons than actual medical fact. Moreover, the study revealed that there is a social reconstruction of narratives that has taken place in each participant’s life due to consuming antiretrovirals. Publicly disclosing their statuses has also proved to have both negative and positive consequences for the individuals and for society at large. While there is a consensus that participants’ illness experiences are directly affected by antiretroviral treatment, each participant’s narrative is different, yet positive.
- Full Text:
A New Synthetic Method for Tetraazatricyclic Derivatives and Evaluation of Their Biological Properties
- Odame, Felix, Betz, Richard, Hosten, Eric C, Krause, Jason, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D, Sayed, Yasien, Frost, P Carminita, Lobb, Kevin A, Tshentu, Zenixole R
- Authors: Odame, Felix , Betz, Richard , Hosten, Eric C , Krause, Jason , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D , Sayed, Yasien , Frost, P Carminita , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123189 , vital:35413 , https://doi.org/10.1002/slct.201802930
- Description: Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2–8 μM without any cytotoxic effects. Compounds 10 (MIC90; 0.9 μM), 11 (MIC90; 0.2 μM), 12 (MIC90; 0.8 μM) and compound 15 (MIC90; 0.8 μM), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions −1 and −3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
- Full Text:
- Authors: Odame, Felix , Betz, Richard , Hosten, Eric C , Krause, Jason , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D , Sayed, Yasien , Frost, P Carminita , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123189 , vital:35413 , https://doi.org/10.1002/slct.201802930
- Description: Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2–8 μM without any cytotoxic effects. Compounds 10 (MIC90; 0.9 μM), 11 (MIC90; 0.2 μM), 12 (MIC90; 0.8 μM) and compound 15 (MIC90; 0.8 μM), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions −1 and −3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
- Full Text:
A peaceful revenge: Achieving structural and agential transformation in a South African context using cognitive justice and emancipatory social learning
- Authors: Burt, Jane C , James, Anna
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/392049 , vital:68717 , xlink:href="https://doi.org/10.1080/14767430.2018.1550312"
- Description: This is an account of the emancipatory struggle that faces agents who seek to change the oppressive social structures associated with neo-liberalism. We begin by ‘digging amongst the bones’ of the calls for resistance that have been declared dead or assimilated/co-opted by neoliberal theorists. This leads us to unearth, then utilize, Paulo Freire’s Pedagogy of the Oppressed, Steve Biko’s Black Consciousness and Shiv Visvanathan's ideas; which are examples of Roy Bhaskar’s transformative dialectic. We argue, using examples, that cognitive justice – a concept common to each of our chosen theorists – is vital in enabling emancipatory social learning. By embracing cognitive justice, the agents gained confidence, which led to their increased ability to champion community and non-academic knowledge. It also uncovered structural tensions – attendant in neoliberalism – around privilege. By articulating these tensions, the participants were able to ‘come closer together’. Such processes, initiated by ensuring cognitive justice, are possible steps in achieving universal solidarity; which is likely to be a necessary step along the path of achieving emancipation.
- Full Text:
- Authors: Burt, Jane C , James, Anna
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/392049 , vital:68717 , xlink:href="https://doi.org/10.1080/14767430.2018.1550312"
- Description: This is an account of the emancipatory struggle that faces agents who seek to change the oppressive social structures associated with neo-liberalism. We begin by ‘digging amongst the bones’ of the calls for resistance that have been declared dead or assimilated/co-opted by neoliberal theorists. This leads us to unearth, then utilize, Paulo Freire’s Pedagogy of the Oppressed, Steve Biko’s Black Consciousness and Shiv Visvanathan's ideas; which are examples of Roy Bhaskar’s transformative dialectic. We argue, using examples, that cognitive justice – a concept common to each of our chosen theorists – is vital in enabling emancipatory social learning. By embracing cognitive justice, the agents gained confidence, which led to their increased ability to champion community and non-academic knowledge. It also uncovered structural tensions – attendant in neoliberalism – around privilege. By articulating these tensions, the participants were able to ‘come closer together’. Such processes, initiated by ensuring cognitive justice, are possible steps in achieving universal solidarity; which is likely to be a necessary step along the path of achieving emancipation.
- Full Text:
A preliminary study of minimal-contention locks
- Machanick, Philip, Mbiyavanga, Mamana
- Authors: Machanick, Philip , Mbiyavanga, Mamana
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439093 , vital:73544 , https://doi.org/10.1145/3278681.3278713
- Description: As multicore CPUs become more common, scalable synchronization primitives have wider use and ideas previously used in large-scale computation are worth re-opening for wider use. In this paper I explore one approach to scalable synchronization, a minimal-contention lock (M-lock). The key idea is to avoid spinning on a global variable but instead for each blocked task (process or thread) to spin on a local lock representing the task that immediately preceded it in attempting to acquire the lock. This creates an ordering based on the order in which tasks attempt to acquire the lock, preventing starvation. The only globally shared variable is a pointer to the next local lock to be contended for. Each contending task swaps the value of this pointer for a pointer to its own variable. It spins on the variable previously pointed to by the global pointer. Each waiting task spins on a lock only seen by itself and the owner of that lock variable. While a task is spinning, the lock variable can be held in its local cache until invalidated by the lock owner when it unsets the lock. Consequently, the amount of bus traffic is considerably less than with a spinlock, which has the pernicious feature that the task releasing the lock is delayed by all the other bus traffic arising from contention for the lock. An MCS lock has similar properties but is more complicated and requires more memory contention-causing operations. This paper outlines the design of the M-lock and provides a preliminary performance analysis.
- Full Text:
- Authors: Machanick, Philip , Mbiyavanga, Mamana
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439093 , vital:73544 , https://doi.org/10.1145/3278681.3278713
- Description: As multicore CPUs become more common, scalable synchronization primitives have wider use and ideas previously used in large-scale computation are worth re-opening for wider use. In this paper I explore one approach to scalable synchronization, a minimal-contention lock (M-lock). The key idea is to avoid spinning on a global variable but instead for each blocked task (process or thread) to spin on a local lock representing the task that immediately preceded it in attempting to acquire the lock. This creates an ordering based on the order in which tasks attempt to acquire the lock, preventing starvation. The only globally shared variable is a pointer to the next local lock to be contended for. Each contending task swaps the value of this pointer for a pointer to its own variable. It spins on the variable previously pointed to by the global pointer. Each waiting task spins on a lock only seen by itself and the owner of that lock variable. While a task is spinning, the lock variable can be held in its local cache until invalidated by the lock owner when it unsets the lock. Consequently, the amount of bus traffic is considerably less than with a spinlock, which has the pernicious feature that the task releasing the lock is delayed by all the other bus traffic arising from contention for the lock. An MCS lock has similar properties but is more complicated and requires more memory contention-causing operations. This paper outlines the design of the M-lock and provides a preliminary performance analysis.
- Full Text:
A psychobiographical study of Temple Grandin
- Authors: Wannenburg, Nicola
- Date: 2018
- Subjects: Grandin, Temple , Psychology Biographical methods , Psychoanalysis , Autistic women United States Biography , Women animal specialists United States Biography , Developmental psychology , Erikson, Erik H (Erik Homburger), 1902-1994
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/57358 , vital:26877
- Description: Psychobiographical researchers methodically formulate life histories and interpret them by means of psychological theories. The research typically focuses on exemplary and completed lives. The cases that are studied are usually of individuals who are of particular interest to society as a result of excelling in their particular fields, be they to benefit or detriment of society. Temple Grandin was chosen for this study using purposive sampling as she meets the psychobiographical requirement of being an extraordinary individual. As an individual with autism Grandin faced many challenges growing up. Despite a difficult and absent beginning, Grandin developed into a stable and scientifically creative adult who contributes to society. She excels as an animal scientist and designer of humane livestock handling facilities and has an international reputation for her contribution to the livestock industry and animal welfare. The primary aim of this study is to describe and interpret the life of Temple Grandin through Erikson’s (1950/1973) theory of psychosocial development. A mixed method approach (Yin, 2006) was employed for the conduction of this study. The overarching data processing and analysis guidelines for this study were provided by Miles and Huberman (1994, 2002a, 2002b). The conduction of the processing and analysis of data was aided by Alexander’s (1988, 1990) method of asking the data questions as well as an integration of Yin’s (2014) time series analysis with Erikson’s (1950/1973) triple bookkeeping approach. This study contributes to the development of psychobiographical research in South Africa as well as to personality and developmental theory.
- Full Text:
- Authors: Wannenburg, Nicola
- Date: 2018
- Subjects: Grandin, Temple , Psychology Biographical methods , Psychoanalysis , Autistic women United States Biography , Women animal specialists United States Biography , Developmental psychology , Erikson, Erik H (Erik Homburger), 1902-1994
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/57358 , vital:26877
- Description: Psychobiographical researchers methodically formulate life histories and interpret them by means of psychological theories. The research typically focuses on exemplary and completed lives. The cases that are studied are usually of individuals who are of particular interest to society as a result of excelling in their particular fields, be they to benefit or detriment of society. Temple Grandin was chosen for this study using purposive sampling as she meets the psychobiographical requirement of being an extraordinary individual. As an individual with autism Grandin faced many challenges growing up. Despite a difficult and absent beginning, Grandin developed into a stable and scientifically creative adult who contributes to society. She excels as an animal scientist and designer of humane livestock handling facilities and has an international reputation for her contribution to the livestock industry and animal welfare. The primary aim of this study is to describe and interpret the life of Temple Grandin through Erikson’s (1950/1973) theory of psychosocial development. A mixed method approach (Yin, 2006) was employed for the conduction of this study. The overarching data processing and analysis guidelines for this study were provided by Miles and Huberman (1994, 2002a, 2002b). The conduction of the processing and analysis of data was aided by Alexander’s (1988, 1990) method of asking the data questions as well as an integration of Yin’s (2014) time series analysis with Erikson’s (1950/1973) triple bookkeeping approach. This study contributes to the development of psychobiographical research in South Africa as well as to personality and developmental theory.
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A psychosocial reading of novice clinical psychologists’ talk about whiteness
- Authors: Kennedy, Brink
- Date: 2018
- Subjects: Clinical psychology Practice South Africa , White people Race identity South Africa , White privilege (Social structure) South Africa , White people Race identity Psychological aspects , Intercultural communication , Psychoanalysis and racism South Africa , Mentalization Based Therapy
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/60212 , vital:27751
- Description: This research presents a case study report of interview encounters with two novice white South African clinical psychologists. A psychosocial research methodology is employed to examine the discursive strategies that participants engage in when speaking about whiteness in the context of their professional identity and practice, as well as to examine the ways in which these discursive strategies support or constrain ‘mentalizing’ in relation to raced experience. One case study highlights an individualistic discourse of ‘racial innocence’, which constructs the speaker as being free of racial enculturation and consciousness, eliding a broader social context. I argue that this discourse closes down mentalizing in relation to more difficult, intractable aspects of raced experience in clinical work, relating to differences in positionality as well as issues of inequality. I also propose that this discourse may be understood in terms of a ‘pretend’ mode of thought, where aspects of the wider social context and of race in particular are experienced as being unrelated to intimate personal experience. The other case study highlights a discourse of ‘uneasy whiteness’ that involves awareness of white positionality, and that is grounded in a constructionist sensibility. This positions the speaker as being inevitably implicated in white privilege and racism in ways that she may be ignorant of. I argue that the discourse facilitates a particular type of mentalizing that is sensitive to the interpellation of intimate personal experience with a wider social context that encompasses a range of discourses and practices. It closes down mentalizing, however, in so far as it allows a reified construction of whiteness. I find the concept of psychic equivalence, which equates external (concrete, factual) reality and internal (subjective, symbolic) reality, useful in terms of understanding this reification. Overall the research highlights the tension between constructionist and individualistic modes of thinking within clinical psychology research and practice in the South African context. At the level of methodology, it presents an example of how these modes may be integrated within research. At the level of content, it explores differences between constructionist and individualistic talk in relation to race and psychological practice.
- Full Text:
- Authors: Kennedy, Brink
- Date: 2018
- Subjects: Clinical psychology Practice South Africa , White people Race identity South Africa , White privilege (Social structure) South Africa , White people Race identity Psychological aspects , Intercultural communication , Psychoanalysis and racism South Africa , Mentalization Based Therapy
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/60212 , vital:27751
- Description: This research presents a case study report of interview encounters with two novice white South African clinical psychologists. A psychosocial research methodology is employed to examine the discursive strategies that participants engage in when speaking about whiteness in the context of their professional identity and practice, as well as to examine the ways in which these discursive strategies support or constrain ‘mentalizing’ in relation to raced experience. One case study highlights an individualistic discourse of ‘racial innocence’, which constructs the speaker as being free of racial enculturation and consciousness, eliding a broader social context. I argue that this discourse closes down mentalizing in relation to more difficult, intractable aspects of raced experience in clinical work, relating to differences in positionality as well as issues of inequality. I also propose that this discourse may be understood in terms of a ‘pretend’ mode of thought, where aspects of the wider social context and of race in particular are experienced as being unrelated to intimate personal experience. The other case study highlights a discourse of ‘uneasy whiteness’ that involves awareness of white positionality, and that is grounded in a constructionist sensibility. This positions the speaker as being inevitably implicated in white privilege and racism in ways that she may be ignorant of. I argue that the discourse facilitates a particular type of mentalizing that is sensitive to the interpellation of intimate personal experience with a wider social context that encompasses a range of discourses and practices. It closes down mentalizing, however, in so far as it allows a reified construction of whiteness. I find the concept of psychic equivalence, which equates external (concrete, factual) reality and internal (subjective, symbolic) reality, useful in terms of understanding this reification. Overall the research highlights the tension between constructionist and individualistic modes of thinking within clinical psychology research and practice in the South African context. At the level of methodology, it presents an example of how these modes may be integrated within research. At the level of content, it explores differences between constructionist and individualistic talk in relation to race and psychological practice.
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A reconciliation study of different resource estimation methods and drill hole spacing as applied to the Langer Heinrich calcrete-hosted uranium deposit, Namibia
- Authors: Baufeldt, Sven
- Date: 2018
- Subjects: Uranium -- Namibia , Calcretes -- Namibia , Carnotite -- Namibia , Uranium mines and mining -- Namibia , Uranium ores -- Geology -- Namibia , Langer-Heinrich Uranium mine
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/62527 , vital:28203
- Description: The Langer Heinrich calcrete hosted uranium deposit is situated approximately 90 km to east of the coastal town of Swakopmund in Namibia. It is run by an Australian owned company, Paladin Energy Limited, along with China National Nuclear Corporation (CNNC) who maintain 25% of the shares. Production commenced in 2007 and has been ongoing. Carnotite is the primary and only ore mineral, and the nature of mineralisation within the Langer Heinrich palaeo channel dictates westward-directed continuous open pit mining. Smaller-scale 1micro pits target near-surface, high-grade, lenses toward the east. The high variability in uranium grade over relatively short distances complicates the grade estimation process. This combined with a low uranium price, and a study aimed at optimising of mine production is one of the key drivers for the research presented in this thesis. The efficacy of four resource estimation techniques, commonly used in the mining industry, are investigated by application to variable exploration, infill drilling and grade-control drill pattern spacing. The drill spacing includes regular grids of 50 m x 50 m, 25 m x 25 m and 12,5 m x 12,5 m exploration data. Also included is grade control drill data, drilled on a 4 m x 4 m spacing. The current selective mining unit (SMU) is 4mE x 4mN x 3mRl which is an indication of the minimum dimension whereby the loading equipment can separate ore from waste. The two datasets are processed by four estimation techniques: Inverse Distance Weighting (IDW, squared and cubed), Ordinary Kriging (OK), Multiple Indicator Kriging (MIK) and Conditional Simulation (CS). The two datasets consisted of real-time mining data from pit G1 (micro-pit) in the eastern parts of the mining licence, and pit H1 (continuous larger open pit) in the western area of the palaeo channel. The reconciliation project aims to provide results suitable for devising optimised mining strategies, particularly in future targets where drill spacing can perhaps be improved to provide suitable data with a greater cost saving strategy. Along with the optimal drill spacing or combination thereof, a preferred estimation technique can be suggested and recommended for future operations that involve mining of surficial calcrete-hosted uranium deposits. Results of this study show that 12,5 m x 12,5 m drill spacing provided estimation accuracies similar to that of the narrow 4 m x 4 m grade control spacing (blast hole drilling spacing). The 12,5 m x 12,5m spacing has potential for accurate grade estimations during mining, and could be supplemented by infill downhole radiometric logging on a 4 m x 4 m spacing when 1 Micro pit: Small pits within palaeo channel usually targeted for their near surface high-grade ore necessary. In general, Multiple Indicator Kriging (MIK) provided the most accurate and robust estimations on the wider spaced exploration data and conditional simulation (CS) proved more efficient on the narrow grade control data. These results correspond with current exploration practices for surficial uranium deposits world-wide. Deposit type, therefore complexity and hence SMU sizes play a pivotal role in drill hole planning and estimation accuracies.
- Full Text:
- Authors: Baufeldt, Sven
- Date: 2018
- Subjects: Uranium -- Namibia , Calcretes -- Namibia , Carnotite -- Namibia , Uranium mines and mining -- Namibia , Uranium ores -- Geology -- Namibia , Langer-Heinrich Uranium mine
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/62527 , vital:28203
- Description: The Langer Heinrich calcrete hosted uranium deposit is situated approximately 90 km to east of the coastal town of Swakopmund in Namibia. It is run by an Australian owned company, Paladin Energy Limited, along with China National Nuclear Corporation (CNNC) who maintain 25% of the shares. Production commenced in 2007 and has been ongoing. Carnotite is the primary and only ore mineral, and the nature of mineralisation within the Langer Heinrich palaeo channel dictates westward-directed continuous open pit mining. Smaller-scale 1micro pits target near-surface, high-grade, lenses toward the east. The high variability in uranium grade over relatively short distances complicates the grade estimation process. This combined with a low uranium price, and a study aimed at optimising of mine production is one of the key drivers for the research presented in this thesis. The efficacy of four resource estimation techniques, commonly used in the mining industry, are investigated by application to variable exploration, infill drilling and grade-control drill pattern spacing. The drill spacing includes regular grids of 50 m x 50 m, 25 m x 25 m and 12,5 m x 12,5 m exploration data. Also included is grade control drill data, drilled on a 4 m x 4 m spacing. The current selective mining unit (SMU) is 4mE x 4mN x 3mRl which is an indication of the minimum dimension whereby the loading equipment can separate ore from waste. The two datasets are processed by four estimation techniques: Inverse Distance Weighting (IDW, squared and cubed), Ordinary Kriging (OK), Multiple Indicator Kriging (MIK) and Conditional Simulation (CS). The two datasets consisted of real-time mining data from pit G1 (micro-pit) in the eastern parts of the mining licence, and pit H1 (continuous larger open pit) in the western area of the palaeo channel. The reconciliation project aims to provide results suitable for devising optimised mining strategies, particularly in future targets where drill spacing can perhaps be improved to provide suitable data with a greater cost saving strategy. Along with the optimal drill spacing or combination thereof, a preferred estimation technique can be suggested and recommended for future operations that involve mining of surficial calcrete-hosted uranium deposits. Results of this study show that 12,5 m x 12,5 m drill spacing provided estimation accuracies similar to that of the narrow 4 m x 4 m grade control spacing (blast hole drilling spacing). The 12,5 m x 12,5m spacing has potential for accurate grade estimations during mining, and could be supplemented by infill downhole radiometric logging on a 4 m x 4 m spacing when 1 Micro pit: Small pits within palaeo channel usually targeted for their near surface high-grade ore necessary. In general, Multiple Indicator Kriging (MIK) provided the most accurate and robust estimations on the wider spaced exploration data and conditional simulation (CS) proved more efficient on the narrow grade control data. These results correspond with current exploration practices for surficial uranium deposits world-wide. Deposit type, therefore complexity and hence SMU sizes play a pivotal role in drill hole planning and estimation accuracies.
- Full Text:
A review of Climate-Smart system innovations in two Agricultural Colleges in the North West Province of South Africa
- Authors: Van Staden, Wilma
- Date: 2018
- Subjects: Crops and climate South Africa North-West , Sustainable agriculture South Africa North-West , Agriculture Environmental aspects South Africa North-West , Agricultural colleges Curricula South Africa , Agricultural innovations , Agricultural ecology South Africa North-West
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/63426 , vital:28410
- Description: This study was centred on the Agricultural Innovation System in the North West Province, South Africa as a response to climate change. The study developed during a time when Climate-Smart Agriculture emerged in policy and was developed as a strategic agricultural innovation process in response to changes in climate that increased food insecurity. The Agricultural Colleges embedded in the agricultural system realised that they were teaching students without a clear provision for climate change and therefore needed to initiate climate responsive innovations to comply with the Climate-Smart strategy that had been proposed by the provincial authorities. This provided the context for the study to track and support the innovation process of transitioning towards Climate-Smart responsive curriculum and learning practices within the system. A theoretical framework for the study was developed using a Cultural Historical Activity Theory perspective. This allowed the researcher to approach the research process as two case studies of innovation within the Agricultural Innovation System of the North West Province. The study developed as an iterative process of innovation support and tracking. At the early stages of the research process, data were generated through document analysis and a survey completed by the research participants at the preliminary consultative workshop. The contextual data allowed the researcher to begin to develop a clear contextual profile for both case studies. The consultative workshops were held to orientate the research around the central problems and challenges related to curriculum alignment with provincial Climate-Smart Agricultural policies. The methodology thereafter was developed as an iterative process of successive intervention-innovation workshops where the participating staff in each college reviewed their curriculum with the support of a Climate-Smart Innovation Tool. This tool was developed as a mediating resource for participants to undertake intervention work towards curriculum innovation in their context. The historical analysis from the two consultative workshops and the data derived from the initial use of the Climate-Smart Innovation Tool was used to model the activity systems in the respective colleges and the provincial system. This analysis enabled the researcher to scope how the system was currently functioning and how it had changed over time. During the workshops, curriculum innovations were reviewed and a fuller picture of the challenges of system innovation emerged, especially from a curriculum innovation vantage point. This system analysis was used to analyse emergent tensions and contradictions within the system and to build a picture of the complexities of participating staff initiating innovations towards Climate-Smart responsiveness in the colleges and within the Agricultural Innovation System. During the review and tracking of the supported innovation process the Climate-Smart Innovation Tool was developed into online sub-tools where either Departments or individual lecturers could review and track their own Climate-Smart responsiveness. The tool was shown to be a useful tool for surfacing contradictions, and identifying absences, and thus for charting out the start of reflexive learning and change processes needed for introducing climate responsive knowledge into the system. The study reveals that catalysing of curriculum and learning system innovation aligned with wider innovations in the agricultural innovation system requires specific tools, time and the understanding of the importance of micro-level innovation. The innovations within the system revealed the significance of allowing for time and processes that facilitate ‘ascending’ from the abstract concept of Climate-Smart Agriculture into more concrete curriculum processes. The curriculum review tool developed for this study served as an important double stimulation tool, along with activity system mapping, and ongoing refinement and clarification of the object of Climate-Smart Agriculture and associated contradictions and action plans for climate smart responsiveness in the college context. The tools and processes that were developed during this study, assisting in the emergence of micro-level innovation of the curriculum and learning system. The barriers and processes hampering curriculum and learning innovation within the system were identified. The study concludes with the recommendations on how a Climate-Smart innovation process might best be supported with reflexive tools within a curriculum and learning system during a time of institutional flux.
- Full Text:
- Authors: Van Staden, Wilma
- Date: 2018
- Subjects: Crops and climate South Africa North-West , Sustainable agriculture South Africa North-West , Agriculture Environmental aspects South Africa North-West , Agricultural colleges Curricula South Africa , Agricultural innovations , Agricultural ecology South Africa North-West
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/63426 , vital:28410
- Description: This study was centred on the Agricultural Innovation System in the North West Province, South Africa as a response to climate change. The study developed during a time when Climate-Smart Agriculture emerged in policy and was developed as a strategic agricultural innovation process in response to changes in climate that increased food insecurity. The Agricultural Colleges embedded in the agricultural system realised that they were teaching students without a clear provision for climate change and therefore needed to initiate climate responsive innovations to comply with the Climate-Smart strategy that had been proposed by the provincial authorities. This provided the context for the study to track and support the innovation process of transitioning towards Climate-Smart responsive curriculum and learning practices within the system. A theoretical framework for the study was developed using a Cultural Historical Activity Theory perspective. This allowed the researcher to approach the research process as two case studies of innovation within the Agricultural Innovation System of the North West Province. The study developed as an iterative process of innovation support and tracking. At the early stages of the research process, data were generated through document analysis and a survey completed by the research participants at the preliminary consultative workshop. The contextual data allowed the researcher to begin to develop a clear contextual profile for both case studies. The consultative workshops were held to orientate the research around the central problems and challenges related to curriculum alignment with provincial Climate-Smart Agricultural policies. The methodology thereafter was developed as an iterative process of successive intervention-innovation workshops where the participating staff in each college reviewed their curriculum with the support of a Climate-Smart Innovation Tool. This tool was developed as a mediating resource for participants to undertake intervention work towards curriculum innovation in their context. The historical analysis from the two consultative workshops and the data derived from the initial use of the Climate-Smart Innovation Tool was used to model the activity systems in the respective colleges and the provincial system. This analysis enabled the researcher to scope how the system was currently functioning and how it had changed over time. During the workshops, curriculum innovations were reviewed and a fuller picture of the challenges of system innovation emerged, especially from a curriculum innovation vantage point. This system analysis was used to analyse emergent tensions and contradictions within the system and to build a picture of the complexities of participating staff initiating innovations towards Climate-Smart responsiveness in the colleges and within the Agricultural Innovation System. During the review and tracking of the supported innovation process the Climate-Smart Innovation Tool was developed into online sub-tools where either Departments or individual lecturers could review and track their own Climate-Smart responsiveness. The tool was shown to be a useful tool for surfacing contradictions, and identifying absences, and thus for charting out the start of reflexive learning and change processes needed for introducing climate responsive knowledge into the system. The study reveals that catalysing of curriculum and learning system innovation aligned with wider innovations in the agricultural innovation system requires specific tools, time and the understanding of the importance of micro-level innovation. The innovations within the system revealed the significance of allowing for time and processes that facilitate ‘ascending’ from the abstract concept of Climate-Smart Agriculture into more concrete curriculum processes. The curriculum review tool developed for this study served as an important double stimulation tool, along with activity system mapping, and ongoing refinement and clarification of the object of Climate-Smart Agriculture and associated contradictions and action plans for climate smart responsiveness in the college context. The tools and processes that were developed during this study, assisting in the emergence of micro-level innovation of the curriculum and learning system. The barriers and processes hampering curriculum and learning innovation within the system were identified. The study concludes with the recommendations on how a Climate-Smart innovation process might best be supported with reflexive tools within a curriculum and learning system during a time of institutional flux.
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A review of the implementation of the CAPS Life Skills curriculum training, as a recontextualising process, in engaging teachers in environmental education in two districts of the Eastern Cape Province
- Authors: Yoyo, Sindiswa
- Date: 2018
- Subjects: Life skills Study and teaching (Continuing education) South Africa Eastern Cape , Environmental education Curricula South Africa Eastern Cape , Teachers In-service training South Africa Eastern Cape , Curriculum change South Africa Eastern Cape , Teachers Education (Continuing education) South Africa Eastern Cape
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/61767 , vital:28057
- Description: This study examines how the implementation of CAPS Life Skills curriculum training (as a recontextualising process) is engaging teachers in environmental education. The research was centred on training manuals for Life Skills (Official Recontextualisation Field) and their use in CAPS training at district level in two Eastern Cape sites of recontextualisation (Professional Recontextualisation Field). During the training, teachers developed lesson plans that were reviewed and group interviews were conducted on the training process and its outcomes. The manuals, training process, lesson plans and interview transcripts were analysed for evidence of environmental education, notably content, teaching and learning methods and assessment strategies. Bernstein’s (1990) framework of the pedagogic device underpins this study. Here the concept of the relay is key for tracking the "relay” of the content, teaching and learning methods and assessment strategies through the processes of recontextualisation into the lesson plans for the field of production. During the process of de-location and relocation, gaps are created and this study sought to track and probe patterns of omissions that took place during the relay process in two cases of training. The review of the in-service training course process of recontextualisation and its cascading approach exposed challenges of omission as it became clear that at each level of the recontextualisation process, gaps were apparent. The study highlighted how the 3-5 day workshop process reviewed was not a robust model for professional development. It was not effective and changes in the mode of delivery and processes of support that reach into curriculum practice in the context of the school are recommended. The study concludes that there is a need for continuous professional development as teachers need ongoing support especially for a "new” curriculum like CAPS that is content driven.
- Full Text:
- Authors: Yoyo, Sindiswa
- Date: 2018
- Subjects: Life skills Study and teaching (Continuing education) South Africa Eastern Cape , Environmental education Curricula South Africa Eastern Cape , Teachers In-service training South Africa Eastern Cape , Curriculum change South Africa Eastern Cape , Teachers Education (Continuing education) South Africa Eastern Cape
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/61767 , vital:28057
- Description: This study examines how the implementation of CAPS Life Skills curriculum training (as a recontextualising process) is engaging teachers in environmental education. The research was centred on training manuals for Life Skills (Official Recontextualisation Field) and their use in CAPS training at district level in two Eastern Cape sites of recontextualisation (Professional Recontextualisation Field). During the training, teachers developed lesson plans that were reviewed and group interviews were conducted on the training process and its outcomes. The manuals, training process, lesson plans and interview transcripts were analysed for evidence of environmental education, notably content, teaching and learning methods and assessment strategies. Bernstein’s (1990) framework of the pedagogic device underpins this study. Here the concept of the relay is key for tracking the "relay” of the content, teaching and learning methods and assessment strategies through the processes of recontextualisation into the lesson plans for the field of production. During the process of de-location and relocation, gaps are created and this study sought to track and probe patterns of omissions that took place during the relay process in two cases of training. The review of the in-service training course process of recontextualisation and its cascading approach exposed challenges of omission as it became clear that at each level of the recontextualisation process, gaps were apparent. The study highlighted how the 3-5 day workshop process reviewed was not a robust model for professional development. It was not effective and changes in the mode of delivery and processes of support that reach into curriculum practice in the context of the school are recommended. The study concludes that there is a need for continuous professional development as teachers need ongoing support especially for a "new” curriculum like CAPS that is content driven.
- Full Text: