Lateral and vertical mineral-chemical variation in high-grade ores of the Kalahari Manganese Field, and implications for ore genesis and geometallurgy
- Authors: Motilaodi, Donald
- Date: 2022-10-14
- Subjects: Manganese ores , Geometallurgy , Hydrothermal alteration , Petrology , Mineralogy , Geochemistry
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/362972 , vital:65379
- Description: The Kalahari Manganese Field (KMF) is a world-class resource of manganese ore hosted by the Paleoproterozoic Hotazel banded iron formation. KMF ores are categorised into two main types, i.e., low-grade, carbonate rich, braunitic ore (Mn≤40wt%) and carbonate-free, high-grade, Ca-braunite+hausmannite ore (Mn≥44wt%). High-grade ores, also known as Wessels type from the homonymous mine in the northernmost KMF, are thought to have formed from variable degrees of hydrothermal carbonate and silica leaching from a low-grade ore precursor, termed Mamatwan-type after the homonymous mine in the southernmost KMF. This project aims to conduct a mineralogical and mineral-chemical study of representative manganese ore samples from a suite of drillcores intersecting both the upper and the lower layers in the northern KMF, covering the areas of Wessels, N’chwaning and Gloria mines. Petrographically, the high-grade Mn ore displays great variability in three-dimensional space. Texturally, the ores exhibit a great variety of textures which may or may not show preservation of the laminated and ovoidal textures that typify the postulated low-grade protore. There is also significant variation in the mineralogical and geochemical characteristics of the high-grade Mn ores both vertically and laterally. Vertical variation includes, probably for the first time, variability between the upper and lower ore layers within individual drillcores of the Hotazel sequence. Mineralogically, the ores contain variable modal abundances of the ore-forming minerals braunite (I, II, “new”) and hausmannite, and much less so of bixbyite, marokite and manganite. Common accessories include andradite, barite and low-Mn carbonate minerals. Chemically, the dominant ore minerals braunite and hausmannite, contain Fe up to 22 and 15wt% respectively, which accounts for the bulk of the iron contained in the ores. Braunite compositions also exhibit a large range with respect to their ratio of Ca/Si. Mineral-specific trace element concentrations for the same minerals measured by LA-ICP-MS, reveal generally large variations from one element to the other. When normalized against the trace element composition of bulk low-grade precursor ore, strong enrichments are recorded for both hausmannite and braunite in selected alkali/alkali earth elements, transition metals and lanthanides, such as Sc, Co, Zn, Cu, Pb, La, and Ce. These are akin to enrichments recorded in average high-grade ore. Although there is also no obvious relationship between Fe content in both hausmannite and braunite and their trace element abundances, the drillcore that captures high-grade ore with the highest trace element concentrations appears to be located most proximal to a major fault. Results collectively suggest that high-grade Mn ores of the KMF have undergone a complex hydrothermal history with a clear and significant metasomatic addition of trace elements into ore-forming minerals. First order trends in the mineralogical and mineral-chemical distribution of the ores in space, suggest hausmannite-dominated ores near the Hotazel suboutcrop, and an apparent decline in ore quality with braunite II-andradite-barite-calcite ores as the major graben fault is approached in a southwesterly direction. The latter trend appears to be at odds with prevailing fault-controlled alteration models. Elucidating that hydrothermal history of the Wessels-type high grade Mn ores of the KMF, will be crucial to understanding the compositional controls of these ores in space, and the potential impact thereof in terms of geometallurgy. , Thesis (MSc) -- Faculty of Science, Geology, 2022
- Full Text:
- Date Issued: 2022-10-14
- Authors: Motilaodi, Donald
- Date: 2022-10-14
- Subjects: Manganese ores , Geometallurgy , Hydrothermal alteration , Petrology , Mineralogy , Geochemistry
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/362972 , vital:65379
- Description: The Kalahari Manganese Field (KMF) is a world-class resource of manganese ore hosted by the Paleoproterozoic Hotazel banded iron formation. KMF ores are categorised into two main types, i.e., low-grade, carbonate rich, braunitic ore (Mn≤40wt%) and carbonate-free, high-grade, Ca-braunite+hausmannite ore (Mn≥44wt%). High-grade ores, also known as Wessels type from the homonymous mine in the northernmost KMF, are thought to have formed from variable degrees of hydrothermal carbonate and silica leaching from a low-grade ore precursor, termed Mamatwan-type after the homonymous mine in the southernmost KMF. This project aims to conduct a mineralogical and mineral-chemical study of representative manganese ore samples from a suite of drillcores intersecting both the upper and the lower layers in the northern KMF, covering the areas of Wessels, N’chwaning and Gloria mines. Petrographically, the high-grade Mn ore displays great variability in three-dimensional space. Texturally, the ores exhibit a great variety of textures which may or may not show preservation of the laminated and ovoidal textures that typify the postulated low-grade protore. There is also significant variation in the mineralogical and geochemical characteristics of the high-grade Mn ores both vertically and laterally. Vertical variation includes, probably for the first time, variability between the upper and lower ore layers within individual drillcores of the Hotazel sequence. Mineralogically, the ores contain variable modal abundances of the ore-forming minerals braunite (I, II, “new”) and hausmannite, and much less so of bixbyite, marokite and manganite. Common accessories include andradite, barite and low-Mn carbonate minerals. Chemically, the dominant ore minerals braunite and hausmannite, contain Fe up to 22 and 15wt% respectively, which accounts for the bulk of the iron contained in the ores. Braunite compositions also exhibit a large range with respect to their ratio of Ca/Si. Mineral-specific trace element concentrations for the same minerals measured by LA-ICP-MS, reveal generally large variations from one element to the other. When normalized against the trace element composition of bulk low-grade precursor ore, strong enrichments are recorded for both hausmannite and braunite in selected alkali/alkali earth elements, transition metals and lanthanides, such as Sc, Co, Zn, Cu, Pb, La, and Ce. These are akin to enrichments recorded in average high-grade ore. Although there is also no obvious relationship between Fe content in both hausmannite and braunite and their trace element abundances, the drillcore that captures high-grade ore with the highest trace element concentrations appears to be located most proximal to a major fault. Results collectively suggest that high-grade Mn ores of the KMF have undergone a complex hydrothermal history with a clear and significant metasomatic addition of trace elements into ore-forming minerals. First order trends in the mineralogical and mineral-chemical distribution of the ores in space, suggest hausmannite-dominated ores near the Hotazel suboutcrop, and an apparent decline in ore quality with braunite II-andradite-barite-calcite ores as the major graben fault is approached in a southwesterly direction. The latter trend appears to be at odds with prevailing fault-controlled alteration models. Elucidating that hydrothermal history of the Wessels-type high grade Mn ores of the KMF, will be crucial to understanding the compositional controls of these ores in space, and the potential impact thereof in terms of geometallurgy. , Thesis (MSc) -- Faculty of Science, Geology, 2022
- Full Text:
- Date Issued: 2022-10-14
The role of a national system of innovation in facilitating development in South Africa from a comparative BRICS perspective
- Authors: Sibhukwana, Andiswa
- Date: 2022-04-06
- Subjects: BRIC countries , Technological innovations Economic aspects South Africa , Economic development South Africa , Economics Mathematical models , Neoclassical school of economics , South Africa Economic conditions , South Africa Economic policy , National systems of innovation
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284616 , vital:56079
- Description: The aim of the dissertation was to investigate whether the adoption of a national system of innovation has helped facilitate development in South Africa from a comparative BRICS perspective. South Africa has an expanding focus on science and technology, as per the Science and Technology White Paper (1996). There appeared to be innovation that had left out much of the citizenry. There continued to be poverty, inequality, and joblessness. The study aimed to understand how the NSI approach could be used to foster inclusive and transformative development. The study used a mixed-methods approach. The qualitative aspect of the research focused on an innovation and public policy study which assessed the various policies and initiatives implemented in each of the BRICS countries to drive innovation and foster development. The qualitative aspect of the study found that the innovation paradigm required governments to adopt a more holistic approach to public policy design and analysis. The quantitative aspect of the research focused on a trend, correlation, and regression analysis. The trend analysis revealed that China and Brazil increased their allocation of resources towards R&D compared to the other countries. Brazil is regarded as a social investment state, while China is a developmental state: this means the state plays an extraordinarily strong coordinative and financing role in the NSI. On the other hand, the correlation matrix for South Africa revealed a statistically significant positive linear association between various NSI indicators and human development. This suggested that the innovation benefits are trickling down to the general citizenry. In essence the study articulated key elements of the understanding of current and potential impacts of technological change in productivity and growth, employment and inequality that can be used for policy making. , Thesis (MEcon) -- Faculty of Commerce, Economics and Economic History, 2022
- Full Text:
- Date Issued: 2022-04-06
- Authors: Sibhukwana, Andiswa
- Date: 2022-04-06
- Subjects: BRIC countries , Technological innovations Economic aspects South Africa , Economic development South Africa , Economics Mathematical models , Neoclassical school of economics , South Africa Economic conditions , South Africa Economic policy , National systems of innovation
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/284616 , vital:56079
- Description: The aim of the dissertation was to investigate whether the adoption of a national system of innovation has helped facilitate development in South Africa from a comparative BRICS perspective. South Africa has an expanding focus on science and technology, as per the Science and Technology White Paper (1996). There appeared to be innovation that had left out much of the citizenry. There continued to be poverty, inequality, and joblessness. The study aimed to understand how the NSI approach could be used to foster inclusive and transformative development. The study used a mixed-methods approach. The qualitative aspect of the research focused on an innovation and public policy study which assessed the various policies and initiatives implemented in each of the BRICS countries to drive innovation and foster development. The qualitative aspect of the study found that the innovation paradigm required governments to adopt a more holistic approach to public policy design and analysis. The quantitative aspect of the research focused on a trend, correlation, and regression analysis. The trend analysis revealed that China and Brazil increased their allocation of resources towards R&D compared to the other countries. Brazil is regarded as a social investment state, while China is a developmental state: this means the state plays an extraordinarily strong coordinative and financing role in the NSI. On the other hand, the correlation matrix for South Africa revealed a statistically significant positive linear association between various NSI indicators and human development. This suggested that the innovation benefits are trickling down to the general citizenry. In essence the study articulated key elements of the understanding of current and potential impacts of technological change in productivity and growth, employment and inequality that can be used for policy making. , Thesis (MEcon) -- Faculty of Commerce, Economics and Economic History, 2022
- Full Text:
- Date Issued: 2022-04-06
A critical assessment of the relationship between the AfCFTA and World Trade Organisation dispute settlement mechanisms, in light of the Conflict of Jurisdiction
- Nhemachena, Tichakunda Charles
- Authors: Nhemachena, Tichakunda Charles
- Date: 2021-10-29
- Subjects: African Continental Free Trade Area , World Trade Organization , Dispute resolution (Law) , Conflict of judicial decisions , Good faith (Law)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192052 , vital:45191
- Description: This thesis interrogates the relationship between the Dispute Settlement Understanding and Africa Continental Free Trade Area dispute settlement mechanism, in light of the conflict of jurisdiction. The conflict of jurisdiction is an adverse effect of the fragmentation of international law. The uncoordinated proliferation of international treaties has increased occurrences of overlapping memberships and overlapping subject matter regulation amongst treaties. Whenever the overlaps mentioned above exist, and a dispute arises concerning matters of overlap, that dispute can be heard in more than one tribunal, giving rise to a conflict of jurisdiction. Jurisdictional conflicts are a problem because they breed uncertainty in the adjudication of disputes; they increase the risk of forum shopping, conflict of rulings, protracted litigation, and waste resources. There is a significant risk for jurisdictional conflicts between the World Trade Organisation and Africa Continental Free Trade Area agreements, because of membership and subject matter overlaps. To mitigate the problems caused by jurisdictional conflicts, the Africa Continental Free Trade Area agreement has incorporated a fork-in-the-road clause. Fork-in-the-road provisions allow parties to choose their preferred forum, and once the forum is chosen, the parties are prohibited from bringing the same dispute to another tribunal. Unfortunately, fork-in-the-road clauses are insufficient in resolving jurisdictional conflicts because they do not bind the Dispute Settlement Understanding. It is only bound to enforce World Trade Organisation obligations and not non-World Trade Organisation obligations. The extent to which non-World Trade Organisation norms apply in the Dispute Settlement Understanding is unsettled, making it difficult to conclude whether a fork-in-the-road provision will be effective an effective solution to potential jurisdictional conflicts. In this thesis, the researcher investigates the prospects of the World Trade Organisation applying the AfCFTA fork-in-the-road clause, directly, as a potential solution to the conflict of jurisdiction. In addition, the researcher will also investigate an alternative means of applying the AfCFTA fork-in-the-road provision, indirectly, using the World Trade Organisation procedural good faith provisions. In conclusion, the researcher provides recommendations on how the World Trade Organisation and the AfCFTA agreement can facilitate the application of fork-in-the-road clauses in the Dispute Settlement Understanding to resolve the conflict of jurisdiction. , Thesis (LLM) -- Faculty of Law, Law, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Nhemachena, Tichakunda Charles
- Date: 2021-10-29
- Subjects: African Continental Free Trade Area , World Trade Organization , Dispute resolution (Law) , Conflict of judicial decisions , Good faith (Law)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192052 , vital:45191
- Description: This thesis interrogates the relationship between the Dispute Settlement Understanding and Africa Continental Free Trade Area dispute settlement mechanism, in light of the conflict of jurisdiction. The conflict of jurisdiction is an adverse effect of the fragmentation of international law. The uncoordinated proliferation of international treaties has increased occurrences of overlapping memberships and overlapping subject matter regulation amongst treaties. Whenever the overlaps mentioned above exist, and a dispute arises concerning matters of overlap, that dispute can be heard in more than one tribunal, giving rise to a conflict of jurisdiction. Jurisdictional conflicts are a problem because they breed uncertainty in the adjudication of disputes; they increase the risk of forum shopping, conflict of rulings, protracted litigation, and waste resources. There is a significant risk for jurisdictional conflicts between the World Trade Organisation and Africa Continental Free Trade Area agreements, because of membership and subject matter overlaps. To mitigate the problems caused by jurisdictional conflicts, the Africa Continental Free Trade Area agreement has incorporated a fork-in-the-road clause. Fork-in-the-road provisions allow parties to choose their preferred forum, and once the forum is chosen, the parties are prohibited from bringing the same dispute to another tribunal. Unfortunately, fork-in-the-road clauses are insufficient in resolving jurisdictional conflicts because they do not bind the Dispute Settlement Understanding. It is only bound to enforce World Trade Organisation obligations and not non-World Trade Organisation obligations. The extent to which non-World Trade Organisation norms apply in the Dispute Settlement Understanding is unsettled, making it difficult to conclude whether a fork-in-the-road provision will be effective an effective solution to potential jurisdictional conflicts. In this thesis, the researcher investigates the prospects of the World Trade Organisation applying the AfCFTA fork-in-the-road clause, directly, as a potential solution to the conflict of jurisdiction. In addition, the researcher will also investigate an alternative means of applying the AfCFTA fork-in-the-road provision, indirectly, using the World Trade Organisation procedural good faith provisions. In conclusion, the researcher provides recommendations on how the World Trade Organisation and the AfCFTA agreement can facilitate the application of fork-in-the-road clauses in the Dispute Settlement Understanding to resolve the conflict of jurisdiction. , Thesis (LLM) -- Faculty of Law, Law, 2021
- Full Text:
- Date Issued: 2021-10-29
A modelling approach to the analysis of complex survey data
- Authors: Dlangamandla, Olwethu
- Date: 2021-10-29
- Subjects: Sampling (Statistics) , Linear models (Statistics) , Multilevel models (Statistics) , Logistic regression analysis , Complex survey data
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192955 , vital:45284
- Description: Surveys are an essential tool for collecting data and most surveys use complex sampling designs to collect the data. Complex sampling designs are used mainly to enhance representativeness in the sample by accounting for the underlying structure of the population. This often results in data that are non-independent and clustered. Ignoring complex design features such as clustering, stratification, multistage and unequal probability sampling may result in inaccurate and incorrect inference. An overview of, and difference between, design-based and model-based approaches to inference for complex survey data has been discussed. This study adopts a model-based approach. The objective of this study is to discuss and describe the modelling approach in analysing complex survey data. This is specifically done by introducing the principle inference methods under which data from complex surveys may be analysed. In particular, discussions on the theory and methods of model fitting for the analysis of complex survey data are presented. We begin by discussing unique features of complex survey data and explore appropriate methods of analysis that account for the complexity inherent in the survey data. We also explore the widely applied logistic regression modelling of binary data in a complex sample survey context. In particular, four forms of logistic regression models are fitted. These models are generalized linear models, multilevel models, mixed effects models and generalized linear mixed models. Simulated complex survey data are used to illustrate the methods and models. Various R packages are used for the analysis. The results presented and discussed in this thesis indicate that a logistic mixed model with first and second level predictors has a better fit compared to a logistic mixed model with first level predictors. In addition, a logistic multilevel model with first and second level predictors and nested random effects provides a better fit to the data compared to other logistic multilevel fitted models. Similar results were obtained from fitting a generalized logistic mixed model with first and second level predictor variables and a generalized linear mixed model with first and second level predictors and nested random effects. , Thesis (MSC) -- Faculty of Science, Statistics, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Dlangamandla, Olwethu
- Date: 2021-10-29
- Subjects: Sampling (Statistics) , Linear models (Statistics) , Multilevel models (Statistics) , Logistic regression analysis , Complex survey data
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192955 , vital:45284
- Description: Surveys are an essential tool for collecting data and most surveys use complex sampling designs to collect the data. Complex sampling designs are used mainly to enhance representativeness in the sample by accounting for the underlying structure of the population. This often results in data that are non-independent and clustered. Ignoring complex design features such as clustering, stratification, multistage and unequal probability sampling may result in inaccurate and incorrect inference. An overview of, and difference between, design-based and model-based approaches to inference for complex survey data has been discussed. This study adopts a model-based approach. The objective of this study is to discuss and describe the modelling approach in analysing complex survey data. This is specifically done by introducing the principle inference methods under which data from complex surveys may be analysed. In particular, discussions on the theory and methods of model fitting for the analysis of complex survey data are presented. We begin by discussing unique features of complex survey data and explore appropriate methods of analysis that account for the complexity inherent in the survey data. We also explore the widely applied logistic regression modelling of binary data in a complex sample survey context. In particular, four forms of logistic regression models are fitted. These models are generalized linear models, multilevel models, mixed effects models and generalized linear mixed models. Simulated complex survey data are used to illustrate the methods and models. Various R packages are used for the analysis. The results presented and discussed in this thesis indicate that a logistic mixed model with first and second level predictors has a better fit compared to a logistic mixed model with first level predictors. In addition, a logistic multilevel model with first and second level predictors and nested random effects provides a better fit to the data compared to other logistic multilevel fitted models. Similar results were obtained from fitting a generalized logistic mixed model with first and second level predictor variables and a generalized linear mixed model with first and second level predictors and nested random effects. , Thesis (MSC) -- Faculty of Science, Statistics, 2021
- Full Text:
- Date Issued: 2021-10-29
A self-emulsifying delivery system loaded with efavirenz: The case for flax-seed oil
- Authors: Mazonde, Priveledge
- Date: 2021-10-29
- Subjects: Drug delivery systems , Linseed oil , Antiretroviral agents , HIV (Viruses) , Drug carriers (Pharmacy) , Solubility , High performance liquid chromatography , Efavirenz
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192944 , vital:45283
- Description: The feasibility of incorporating efavirenz (EFV), an antiretroviral agent against HIV into a lipid-based self-emulsifying drug delivery system (SEDDS) containing vegetable oils was investigated. EFV has poor aqueous solubility and is classified under the Biopharmaceutical Classification System (BCS) as a class II compound with highly permeability, its aqueous solubility is less than 10 mg/ml and is defined as a practically insoluble compound with a consequent poor bioavailability of approximately 40%, and erratic dissolution behaviour. SEDDS formulations have been shown to improve the aqueous solubility and consequently the bioavailability of BCS II compounds such as EFV. EFV is a first line antiviral agent used in combination with other agents in antiretroviral therapy (ART). Among the number of NNRTIs approved for use in HIV treatment, EFV is one of the most commonly prescribed drug. Statistical methods and Design of Experiments (DoE) using Response Surface Methodology (RSM), specifically a Central Composite Design (CCD), were used to facilitate the development of a reversed-phase high performance liquid chromatographic (HPLC) method for the quantitation of EFV during formulation product and process development studies. A rapid, accurate, precise and sensitive HPLC method with ultraviolet (UV) detection was developed, optimised and validated for the in-vitro analysis of EFV in a total run time under 10 minutes for the elution of both EFV and loratidine which was used as the internal standard (IS). The method was then successfully applied to the determination of EFV in commercially available tablets. Excipient screening was undertaken using solubility studies and revealed that EFV had highest solubility in flaxseed oil in comparison to soybean, macadamia, grapeseed, sunflower and olive oils. The non-ionic Tween® 80 and Span® 20 were selected as surfactant and co-surfactant, respectively with ethanol co-solvent as they exhibited improved miscibility with co-solvent. Pre-formulation studies were undertaken to investigate the compatibility of the API with excipients and to identify a nano-emulsion region and other emulsion types using pseudoternary phase diagrams. The phase behaviour of crude cold pressed flaxseed oil with the selected non-ionic surfactants revealed an area within pseudo-ternary phase diagrams for different surfactant-mixtures formed gels/semisolid structures which can be exploited for other drug delivery strategies that require such properties. Fourier transform infrared spectroscopy (FT-IR), powder x-ray diffraction (XRD) and Raman spectroscopy were used to identify and assess the compatibility of EFV with chosen excipients. 2 A reduction in the peak intensity was observed for EFV when combined with each hydrophobic/lipid excipient evaluated revealing that there was a marked reduction in the crystallinity of the EFV. A decrease in crystallinity in comparison with the bulk API may indicate that EFV were amorphous or sequestered in a molecular dispersion and exhibited an increased solubility for the molecule. Flaxseed oil was used as the oil phase in studies for the optimization of surfactant mixtures undertaken using DoE, specifically a D-optimal mixtures design with the flaxseed oil content set at 10% m/m was performed. Solutions from the desired optimization function were produced based on desirability and five nanoemulsion formulations were produced and characterized in terms of in vitro release of efavirenz, drug loading capacity, Zeta Potential, droplet sizes and polydispersity index (PDI). Kinetically stable nanoemulsions containing 10% m/m flaxseed oil were successfully manufactured and assessed. Droplet sizes ranged between 156 and 225 nm, Zeta Potential between −24 and −41 mV and all formulations were found to be monodisperse with polydispersity indices ≤ 0.487. SEDDS formulations of EFV in nano-sized carriers were developed and optimised, in vitro drug release varied with varying amounts of ethanol in the formulation producing formulations that exhibited differently modulated drug in-vitro release profiles that may be further manipulated for better performance and therapeutic outcomes in terms of solubility and possibly bioavailability of EFV when delivered using SEDDS rather than using tablets which in turn may lead to better therapeutic outcomes for patients with HIV. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Mazonde, Priveledge
- Date: 2021-10-29
- Subjects: Drug delivery systems , Linseed oil , Antiretroviral agents , HIV (Viruses) , Drug carriers (Pharmacy) , Solubility , High performance liquid chromatography , Efavirenz
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192944 , vital:45283
- Description: The feasibility of incorporating efavirenz (EFV), an antiretroviral agent against HIV into a lipid-based self-emulsifying drug delivery system (SEDDS) containing vegetable oils was investigated. EFV has poor aqueous solubility and is classified under the Biopharmaceutical Classification System (BCS) as a class II compound with highly permeability, its aqueous solubility is less than 10 mg/ml and is defined as a practically insoluble compound with a consequent poor bioavailability of approximately 40%, and erratic dissolution behaviour. SEDDS formulations have been shown to improve the aqueous solubility and consequently the bioavailability of BCS II compounds such as EFV. EFV is a first line antiviral agent used in combination with other agents in antiretroviral therapy (ART). Among the number of NNRTIs approved for use in HIV treatment, EFV is one of the most commonly prescribed drug. Statistical methods and Design of Experiments (DoE) using Response Surface Methodology (RSM), specifically a Central Composite Design (CCD), were used to facilitate the development of a reversed-phase high performance liquid chromatographic (HPLC) method for the quantitation of EFV during formulation product and process development studies. A rapid, accurate, precise and sensitive HPLC method with ultraviolet (UV) detection was developed, optimised and validated for the in-vitro analysis of EFV in a total run time under 10 minutes for the elution of both EFV and loratidine which was used as the internal standard (IS). The method was then successfully applied to the determination of EFV in commercially available tablets. Excipient screening was undertaken using solubility studies and revealed that EFV had highest solubility in flaxseed oil in comparison to soybean, macadamia, grapeseed, sunflower and olive oils. The non-ionic Tween® 80 and Span® 20 were selected as surfactant and co-surfactant, respectively with ethanol co-solvent as they exhibited improved miscibility with co-solvent. Pre-formulation studies were undertaken to investigate the compatibility of the API with excipients and to identify a nano-emulsion region and other emulsion types using pseudoternary phase diagrams. The phase behaviour of crude cold pressed flaxseed oil with the selected non-ionic surfactants revealed an area within pseudo-ternary phase diagrams for different surfactant-mixtures formed gels/semisolid structures which can be exploited for other drug delivery strategies that require such properties. Fourier transform infrared spectroscopy (FT-IR), powder x-ray diffraction (XRD) and Raman spectroscopy were used to identify and assess the compatibility of EFV with chosen excipients. 2 A reduction in the peak intensity was observed for EFV when combined with each hydrophobic/lipid excipient evaluated revealing that there was a marked reduction in the crystallinity of the EFV. A decrease in crystallinity in comparison with the bulk API may indicate that EFV were amorphous or sequestered in a molecular dispersion and exhibited an increased solubility for the molecule. Flaxseed oil was used as the oil phase in studies for the optimization of surfactant mixtures undertaken using DoE, specifically a D-optimal mixtures design with the flaxseed oil content set at 10% m/m was performed. Solutions from the desired optimization function were produced based on desirability and five nanoemulsion formulations were produced and characterized in terms of in vitro release of efavirenz, drug loading capacity, Zeta Potential, droplet sizes and polydispersity index (PDI). Kinetically stable nanoemulsions containing 10% m/m flaxseed oil were successfully manufactured and assessed. Droplet sizes ranged between 156 and 225 nm, Zeta Potential between −24 and −41 mV and all formulations were found to be monodisperse with polydispersity indices ≤ 0.487. SEDDS formulations of EFV in nano-sized carriers were developed and optimised, in vitro drug release varied with varying amounts of ethanol in the formulation producing formulations that exhibited differently modulated drug in-vitro release profiles that may be further manipulated for better performance and therapeutic outcomes in terms of solubility and possibly bioavailability of EFV when delivered using SEDDS rather than using tablets which in turn may lead to better therapeutic outcomes for patients with HIV. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-10-29
An analysis of citizen participation in service delivery in Zimbabwe’s small towns: A case study of Chiredzi Town Council
- Authors: Matsilele, Blessing
- Date: 2021-10-29
- Subjects: Municipal services Zimbabwe Chiredzi Rural District , Political participation Zimbabwe Chiredzi Rural District , Social capital (Sociology) Zimbabwe Chiredzi Rural District , Municipal services Zimbabwe Chiredzi Rural District Citizen participation , Community development Zimbabwe Chiredzi Rural District
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190099 , vital:44963
- Description: Over the years, there have been complaints of poor service delivery in Zimbabwe’s Urban Councils. Newspapers in Zimbabwe have been filled with stories of poor service delivery and citizen grievances. Existing literature on service delivery has focused on the causes of poor service delivery, blaming them solely on the local government authorities. The literature has blamed poor service delivery in Zimbabwe on corruption, polarisation, politicisation, and incapacitation amongst other things. What is not highlighted is the role that citizens play and their responsibility in ensuring that there is proper service delivery. This thesis discusses the ways in which citizens participate in local government service delivery in Chiredzi which is an urban Council in Zimbabwe. To establish citizen participation in Chiredzi, this theory draws upon the social capital theory focusing on its trust, network, and norms aspect. Social capital facilitates an analysis of citizen participation and service delivery in Chiredzi. For this study,a qualitative research methodology was used. This methodology consisted of semi-structured telephone interviews with participants together with relevant documents. It was concluded that there is a need to educate citizens on their roles and responsibilities in local government to improve the state of service delivery. , Thesis (MSocSci) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Matsilele, Blessing
- Date: 2021-10-29
- Subjects: Municipal services Zimbabwe Chiredzi Rural District , Political participation Zimbabwe Chiredzi Rural District , Social capital (Sociology) Zimbabwe Chiredzi Rural District , Municipal services Zimbabwe Chiredzi Rural District Citizen participation , Community development Zimbabwe Chiredzi Rural District
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190099 , vital:44963
- Description: Over the years, there have been complaints of poor service delivery in Zimbabwe’s Urban Councils. Newspapers in Zimbabwe have been filled with stories of poor service delivery and citizen grievances. Existing literature on service delivery has focused on the causes of poor service delivery, blaming them solely on the local government authorities. The literature has blamed poor service delivery in Zimbabwe on corruption, polarisation, politicisation, and incapacitation amongst other things. What is not highlighted is the role that citizens play and their responsibility in ensuring that there is proper service delivery. This thesis discusses the ways in which citizens participate in local government service delivery in Chiredzi which is an urban Council in Zimbabwe. To establish citizen participation in Chiredzi, this theory draws upon the social capital theory focusing on its trust, network, and norms aspect. Social capital facilitates an analysis of citizen participation and service delivery in Chiredzi. For this study,a qualitative research methodology was used. This methodology consisted of semi-structured telephone interviews with participants together with relevant documents. It was concluded that there is a need to educate citizens on their roles and responsibilities in local government to improve the state of service delivery. , Thesis (MSocSci) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
An analysis of the medicines regulatory environment in sub-Saharan Africa and the African Medicines Regulatory Harmonization Initiative
- Authors: Feka, Cedric Nyahchong
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192408 , vital:45223
- Description: Thesis (MSc (Pharm)) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Feka, Cedric Nyahchong
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192408 , vital:45223
- Description: Thesis (MSc (Pharm)) -- Faculty of Pharmacy, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-10-29
An ethnographic investigation of the implementation of the bilingual-bicultural approach for educating deaf learners focusing on South African sign language teaching at FET level
- Authors: Tunzelana, Nomava Mercy
- Date: 2021-10-29
- Subjects: South African Sign Language Study and teaching (Higher) , Sign language acquisition South Africa , Education, Bilingual South Africa , Biculturalism South Africa , Ethnology South Africa , Culturally relevant pedagogy South Africa , Deaf students South Africa , South Africa. Department of Basic Education , Curriculum-based assessment South Africa , South African Curriculum Assessment and Policy Statement (CAPS)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192353 , vital:45218
- Description: This half-thesis reports on an ethnographic investigation of the implementation of the Bilingual-Bicultural Approach for educating Deaf learners, focusing on South African Sign Language (SASL) teaching at the Further Education and Training (FET) level in a South African School for the Deaf in the Eastern Cape. The investigation occurs within the context of the introduction, in 2015, of the SASL Curriculum and Assessment Policy Statement (CAPS) by the Department of Basic Education (DBE). The SASL CAPS introduces an approach to teaching the Deaf known as the Bilingual-Bicultural Approach. This is an approach in which natural sign language (such as SASL) is taught first and used to learn a spoken language such as English for reading and writing. Previous research on a contrastive analysis of South African English and SASL reveals that SASL is a Topic-Comment language. It is sometimes Object-Subject-Verb (OSV) or Subject-Object-Verb (SOV) while the word order of South African English is Subject-Verb-Object (SVO). Semi-structured interviews of hearing and Deaf participants reveal serious tensions between the staff and the hearing staff because Deaf culture is not adhered to by some of the hearing staff. These tensions have a negative impact on the culture of learning and teaching at the school. Observations of four lessons at an FET class taught by an SASL FET teacher show that in her teaching, SASL syntax is used in keeping with the principles of the Bilingual-Bicultural Approach. However, her signing is accompanied by unvoiced spoken language due to the influence of a previously used approach called Total Communication (TC). One of the learners, Lulu, who contributes considerably more often than other learners in the lesson, also shows the same influence of TC. Other learners are either withdrawn or copy signs from Lulu. The study concludes with the recommendation that SASL be used for initiating newcomers to school as opposed to Signed English because research in bilingualism suggests that second language learners need one natural language established first before attempting to learn a second language. Teachers are recommended to immerse themselves into Deaf culture to acquire fluency. Comments from some participants suggest that teachers require vigorous training in the Bilingual-Bicultural Approach on a continuous basis. , Thesis (MA) -- Faculty of Humanities, Linguistics and Applied Languages Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Tunzelana, Nomava Mercy
- Date: 2021-10-29
- Subjects: South African Sign Language Study and teaching (Higher) , Sign language acquisition South Africa , Education, Bilingual South Africa , Biculturalism South Africa , Ethnology South Africa , Culturally relevant pedagogy South Africa , Deaf students South Africa , South Africa. Department of Basic Education , Curriculum-based assessment South Africa , South African Curriculum Assessment and Policy Statement (CAPS)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192353 , vital:45218
- Description: This half-thesis reports on an ethnographic investigation of the implementation of the Bilingual-Bicultural Approach for educating Deaf learners, focusing on South African Sign Language (SASL) teaching at the Further Education and Training (FET) level in a South African School for the Deaf in the Eastern Cape. The investigation occurs within the context of the introduction, in 2015, of the SASL Curriculum and Assessment Policy Statement (CAPS) by the Department of Basic Education (DBE). The SASL CAPS introduces an approach to teaching the Deaf known as the Bilingual-Bicultural Approach. This is an approach in which natural sign language (such as SASL) is taught first and used to learn a spoken language such as English for reading and writing. Previous research on a contrastive analysis of South African English and SASL reveals that SASL is a Topic-Comment language. It is sometimes Object-Subject-Verb (OSV) or Subject-Object-Verb (SOV) while the word order of South African English is Subject-Verb-Object (SVO). Semi-structured interviews of hearing and Deaf participants reveal serious tensions between the staff and the hearing staff because Deaf culture is not adhered to by some of the hearing staff. These tensions have a negative impact on the culture of learning and teaching at the school. Observations of four lessons at an FET class taught by an SASL FET teacher show that in her teaching, SASL syntax is used in keeping with the principles of the Bilingual-Bicultural Approach. However, her signing is accompanied by unvoiced spoken language due to the influence of a previously used approach called Total Communication (TC). One of the learners, Lulu, who contributes considerably more often than other learners in the lesson, also shows the same influence of TC. Other learners are either withdrawn or copy signs from Lulu. The study concludes with the recommendation that SASL be used for initiating newcomers to school as opposed to Signed English because research in bilingualism suggests that second language learners need one natural language established first before attempting to learn a second language. Teachers are recommended to immerse themselves into Deaf culture to acquire fluency. Comments from some participants suggest that teachers require vigorous training in the Bilingual-Bicultural Approach on a continuous basis. , Thesis (MA) -- Faculty of Humanities, Linguistics and Applied Languages Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
An exploration of how schools and teachers interpret and implement the Language in Education Policy for their classroom practice: a case study
- Authors: Sibanda, Sikhumbuzo
- Date: 2021-10-29
- Subjects: Language policy South Africa , Education and state South Africa , Critical discourse analysis , Native language and education South Africa Kuruman , Educational change South Africa , South Africa Colonial influence , South African Language in Education Policy
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192035 , vital:45190
- Description: This case study explored how schools and teachers interpret and implement the Language in Education Policy for their classroom practices. Scholars like Alexander and Block (2012) note that the South African Language in Education Policy (LiEP) is one of the advanced policies globally. Other scholars like Perry (2015) and Ngcobo (2015) state that the policy in South Africa has failed when it comes to implementation. It is against this background that the research explored how schools and teachers interpret and implement the Language in Education Policy for their classroom practice in three primary schools in Kuruman, Northern Cape. The research methodology was qualitative and it used a case study approach. The study is informed and framed by the Language Policy framework and the CDA (Critical Discourse Analysis). The research sites were three Grade 4 classes and the participants were three teachers, three principals and three SGB Chairpersons from three different schools (one school in deep rural, another in semi-urban and the third in urban) in Kuruman. This case study, located in the interpretive paradigm, employed individual semi-structured interviews, non-participant classroom observations, document analyses and field notes for data collection. The study revealed that teachers are not versed in LiEP and their classroom practice is therefore not based on policy but on their own perceptions. Classroom practices were incongruent with what the Language in Education Policy requires. Even other documents which support the Language in Education Policy like the school language policies, were not used as guiding documents for classroom practice. Lastly, this study revealed that, despite a plethora of literature on how practice engages and disengages with Language in Education Policy (LiEP), the deconstruction of colonial and apartheid education is still a challenge especially in language use, perceptions of mother tongue instruction and the hegemony of English. One of the recommendations of this study is that teachers must be taught to use Languages of Learning and teaching required in their areas and they should also be given continuous professional development courses on policies so as to improve their practice. Language Policy Units should be set up within the provincial and district Departments of Education that would support the implementation of LiEP. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Sibanda, Sikhumbuzo
- Date: 2021-10-29
- Subjects: Language policy South Africa , Education and state South Africa , Critical discourse analysis , Native language and education South Africa Kuruman , Educational change South Africa , South Africa Colonial influence , South African Language in Education Policy
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192035 , vital:45190
- Description: This case study explored how schools and teachers interpret and implement the Language in Education Policy for their classroom practices. Scholars like Alexander and Block (2012) note that the South African Language in Education Policy (LiEP) is one of the advanced policies globally. Other scholars like Perry (2015) and Ngcobo (2015) state that the policy in South Africa has failed when it comes to implementation. It is against this background that the research explored how schools and teachers interpret and implement the Language in Education Policy for their classroom practice in three primary schools in Kuruman, Northern Cape. The research methodology was qualitative and it used a case study approach. The study is informed and framed by the Language Policy framework and the CDA (Critical Discourse Analysis). The research sites were three Grade 4 classes and the participants were three teachers, three principals and three SGB Chairpersons from three different schools (one school in deep rural, another in semi-urban and the third in urban) in Kuruman. This case study, located in the interpretive paradigm, employed individual semi-structured interviews, non-participant classroom observations, document analyses and field notes for data collection. The study revealed that teachers are not versed in LiEP and their classroom practice is therefore not based on policy but on their own perceptions. Classroom practices were incongruent with what the Language in Education Policy requires. Even other documents which support the Language in Education Policy like the school language policies, were not used as guiding documents for classroom practice. Lastly, this study revealed that, despite a plethora of literature on how practice engages and disengages with Language in Education Policy (LiEP), the deconstruction of colonial and apartheid education is still a challenge especially in language use, perceptions of mother tongue instruction and the hegemony of English. One of the recommendations of this study is that teachers must be taught to use Languages of Learning and teaching required in their areas and they should also be given continuous professional development courses on policies so as to improve their practice. Language Policy Units should be set up within the provincial and district Departments of Education that would support the implementation of LiEP. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-10-29
An interpretative phenomenological analysis of mothers’ experiences raising an autistic child
- Authors: Hewson, Aimee Jessica
- Date: 2021-10-29
- Subjects: Autism spectrum disorders South Africa , Autism spectrum disorders in children South Africa , Mothers of children with disabilities South Africa , Phenomenological psychology , Qualitative research , Interpretative phenomenological analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190725 , vital:45022
- Description: There has been an increasing research focus on Autism Spectrum Disorder (ASD) and the experiences of those affected by autism. Previous research has demonstrated that mothers experience difficulties in all spheres related to their autistic child. Mothers were focused on exclusively in this study as previous research found that it is mostly mothers who take on the primary caring role for their children. As a result, this research aimed to explore the perceptions and experience of six South African mothers raising their ASD child. This research used a qualitative research approach and an interpretative phenomenological analysis methodology. Two semi-structured interviews were held with each participant, with interviews being audio recorded. After analysis, five themes were found, namely: (1) learning their child has a condition or diagnosis, (2) learning and sharing about ASD, (3) the mothering experience, (4) interventions and cost and (5) supportive resources. Careful anonymisation choices were made in this research to ensure the anonymity of participants as best as possible, due to the recruitment through a gatekeeper organisation and snowball sampling. The main findings of this study were that mothers experienced difficulties and challenges as they navigated the medical world in search of a diagnosis for their child. Mothers also reported following their intuition when it came to their children’s care, interventions, and schooling. The passage of time was a significant issue to mothers, as they described several delays and waiting periods. Mothers also described their concerns regarding their children’s future and the fact that their child would be dependent on them and would not be able to form autonomous mature relationships with others. They also reported various thoughts on disclosing their child’s diagnosis to their children. This research, therefore, added to and expanded upon South African literature on the experiences of mothers raising their ASD child. Concurring with previous research, this project found that mothers experience many challenges in the raising of their ASD child. , Thesis (MSocSci) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Hewson, Aimee Jessica
- Date: 2021-10-29
- Subjects: Autism spectrum disorders South Africa , Autism spectrum disorders in children South Africa , Mothers of children with disabilities South Africa , Phenomenological psychology , Qualitative research , Interpretative phenomenological analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190725 , vital:45022
- Description: There has been an increasing research focus on Autism Spectrum Disorder (ASD) and the experiences of those affected by autism. Previous research has demonstrated that mothers experience difficulties in all spheres related to their autistic child. Mothers were focused on exclusively in this study as previous research found that it is mostly mothers who take on the primary caring role for their children. As a result, this research aimed to explore the perceptions and experience of six South African mothers raising their ASD child. This research used a qualitative research approach and an interpretative phenomenological analysis methodology. Two semi-structured interviews were held with each participant, with interviews being audio recorded. After analysis, five themes were found, namely: (1) learning their child has a condition or diagnosis, (2) learning and sharing about ASD, (3) the mothering experience, (4) interventions and cost and (5) supportive resources. Careful anonymisation choices were made in this research to ensure the anonymity of participants as best as possible, due to the recruitment through a gatekeeper organisation and snowball sampling. The main findings of this study were that mothers experienced difficulties and challenges as they navigated the medical world in search of a diagnosis for their child. Mothers also reported following their intuition when it came to their children’s care, interventions, and schooling. The passage of time was a significant issue to mothers, as they described several delays and waiting periods. Mothers also described their concerns regarding their children’s future and the fact that their child would be dependent on them and would not be able to form autonomous mature relationships with others. They also reported various thoughts on disclosing their child’s diagnosis to their children. This research, therefore, added to and expanded upon South African literature on the experiences of mothers raising their ASD child. Concurring with previous research, this project found that mothers experience many challenges in the raising of their ASD child. , Thesis (MSocSci) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
An interpretive analysis of the experiences of adults working as university support staff
- Authors: Zini, Thembela Nomonde
- Date: 2021-10-29
- Subjects: Universities and colleges South Africa , Universities and colleges Employees , Universities and colleges Sociological aspects , Identity (Psychology) , Identity (Psychology) Social aspects , Work Psychological aspects , Work Social aspects , Interpretive Phenomenological Analysis (IPA)
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/10962/188888 , vital:44795
- Description: Work means different things to different people and the different meanings they make of their work has the unique ability of contributing to a sense of identity. Support staff have to negotiate their personal identities and social identities to develop a work identity in the complex South African context that has its unique challenges. Exploring how support staff make sense of their experiences, when it comes to their identities, reveals what identity work strategies they use. An interpretative phenomenological method of inquiry was employed as an initial research method to explore the aspects that impact on the identity formation of support staff at Rhodes University. The study aims to investigate how support staff have constructed a work identity through their constructions of their experiences. Six participants were recruited through a purposive sampling method and data were collected using semi-structured interviews. The study revealed that support staff use the following identity work strategies to negotiate their identities: Financial, Personality, Career mobility, Roles, Status and Esteem, Subjective wellbeing. These themes were derived from the narratives of the participants, using the emphases in the data and suggest that support staff use identity work strategies both outside and within the workplace, when constructing their work identities. The study illustrates that as people ascribe different meanings to work, they will define and negotiate their identities in the workplace based upon those meanings. Identity work is indeed challenging for support staff because they need to use identity strategies that are enhancing to their self-esteem. Identity work is a challenging task because of the many tensions and demands of modern society, as adults negotiate their needs to provide for families and to find ways to construct their job status in positive ways. , Thesis (MA) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Zini, Thembela Nomonde
- Date: 2021-10-29
- Subjects: Universities and colleges South Africa , Universities and colleges Employees , Universities and colleges Sociological aspects , Identity (Psychology) , Identity (Psychology) Social aspects , Work Psychological aspects , Work Social aspects , Interpretive Phenomenological Analysis (IPA)
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/10962/188888 , vital:44795
- Description: Work means different things to different people and the different meanings they make of their work has the unique ability of contributing to a sense of identity. Support staff have to negotiate their personal identities and social identities to develop a work identity in the complex South African context that has its unique challenges. Exploring how support staff make sense of their experiences, when it comes to their identities, reveals what identity work strategies they use. An interpretative phenomenological method of inquiry was employed as an initial research method to explore the aspects that impact on the identity formation of support staff at Rhodes University. The study aims to investigate how support staff have constructed a work identity through their constructions of their experiences. Six participants were recruited through a purposive sampling method and data were collected using semi-structured interviews. The study revealed that support staff use the following identity work strategies to negotiate their identities: Financial, Personality, Career mobility, Roles, Status and Esteem, Subjective wellbeing. These themes were derived from the narratives of the participants, using the emphases in the data and suggest that support staff use identity work strategies both outside and within the workplace, when constructing their work identities. The study illustrates that as people ascribe different meanings to work, they will define and negotiate their identities in the workplace based upon those meanings. Identity work is indeed challenging for support staff because they need to use identity strategies that are enhancing to their self-esteem. Identity work is a challenging task because of the many tensions and demands of modern society, as adults negotiate their needs to provide for families and to find ways to construct their job status in positive ways. , Thesis (MA) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
Application of computer-aided drug design for identification of P. falciparum inhibitors
- Authors: Diallo, Bakary N’tji
- Date: 2021-10-29
- Subjects: Plasmodium falciparum , Malaria -- Chemotherapy , Molecular dynamics , Antimalarials , Cheminformatics , Drug development , Ligand binding (Biochemistry) , Plasmodium falciparum1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) , South African Natural Compounds Database
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192798 , vital:45265 , 10.21504/10962/192798
- Description: Malaria is a millennia-old disease with the first recorded cases dating back to 2700 BC found in Chinese medical records, and later in other civilizations. It has claimed human lives to such an extent that there are a notable associated socio-economic consequences. Currently, according to the World Health Organization (WHO), Africa holds the highest disease burden with 94% of deaths and 82% of cases with P. falciparum having ~100% prevalence. Chemotherapy, such as artemisinin combination therapy, has been and continues to be the work horse in the fight against the disease, together with seasonal malaria chemoprevention and the use of insecticides. Natural products such as quinine and artemisinin are particularly important in terms of their antimalarial activity. The emphasis in current chemotherapy research is the need for time and cost-effective workflows focussed on new mechanisms of action (MoAs) covering the target candidate profiles (TCPs). Despite a decline in cases over the past decades with, countries increasingly becoming certified malaria free, a stalling trend has been observed in the past five years resulting in missing the 2020 Global Technical Strategy (GTS) milestones. With no effective vaccine, a reduction in funding, slower drug approval than resistance emergence from resistant and invasive vectors, and threats in diagnosis with the pfhrp2/3 gene deletion, malaria remains a major health concern. Motivated by these reasons, the primary aim of this work was a contribution to the antimalarial pipeline through in silico approaches focusing on P. falciparum. We first intended an exploration of malarial targets through a proteome scale screening on 36 targets using multiple metrics to account for the multi-objective nature of drug discovery. The continuous growth of structural data offers the ideal scenario for mining new MoAs covering antimalarials TCPs. This was combined with a repurposing strategy using a set of orally available FDA approved drugs. Further, use was made of time- and cost-effective strategies combining QVina-W efficiency metrics that integrate molecular properties, GRIM rescoring for molecular interactions and a hydrogen mass repartitioning (HMR) molecular dynamics (MD) scheme for accelerated development of antimalarials in the context of resistance. This pipeline further integrates a complex ranking for better drug-target selectivity, and normalization strategies to overcome docking scoring function bias. The different metrics, ranking, normalization strategies and their combinations were first assessed using their mean ranking error (MRE). A version combining all metrics was used to select 36 unique protein-ligand complexes, assessed in MD, with the final retention of 25. From the 16 in vitro tested hits of the 25, fingolimod, abiraterone, prazosin, and terazosin showed antiplasmodial activity with IC50 2.21, 3.37, 16.67 and 34.72 μM respectively and of these, only fingolimod was found to be not safe with respect to human cell viability. These compounds were predicted active on different molecular targets, abiraterone was predicted to interact with a putative liver-stage essential target, hence promising as a transmission-blocking agent. The pipeline had a promising 25% hit rate considering the proteome-scale and use of cost-effective approaches. Secondly, we focused on Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) using a more extensive screening pipeline to overcome some of the current in silico screening limitations. Starting from the ZINC lead-like library of ~3M, hierarchical ligand-based virtual screening (LBVS) and structure-based virtual screening (SBVS) approaches with molecular docking and re-scoring using eleven scoring functions (SFs) were used. Later ranking with an exponential consensus strategy was included. Selected hits were further assessed through Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA), advanced MD sampling in a ligand pulling simulations and (Weighted Histogram Analysis Method) WHAM analysis for umbrella sampling (US) to derive binding free energies. Four leads had better predicted affinities in US than LC5, a 280 nM potent PfDXR inhibitor with ZINC000050633276 showing a promising binding of -20.43 kcal/mol. As shown with fosmidomycin, DXR inhibition offers fast acting compounds fulfilling antimalarials TCP1. Yet, fosmidomycin has a high polarity causing its short half-life and hampering its clinical use. These leads scaffolds are different from fosmidomycin and hence may offer better pharmacokinetic and pharmacodynamic properties and may also be promising for lead optimization. A combined analysis of residues’ contributions to the free energy of binding in MM-PBSA and to steered molecular dynamics (SMD) Fmax indicated GLU233, CYS268, SER270, TRP296, and HIS341 as exploitable for compound optimization. Finally, we updated the SANCDB library with new NPs and their commercially available analogs as a solution to NP availability. The library is extended to 1005 compounds from its initial 600 compounds and the database is integrated to Mcule and Molport APIs for analogs automatic update. The new set may contribute to virtual screening and to antimalarials as the most effective ones have NP origin. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Diallo, Bakary N’tji
- Date: 2021-10-29
- Subjects: Plasmodium falciparum , Malaria -- Chemotherapy , Molecular dynamics , Antimalarials , Cheminformatics , Drug development , Ligand binding (Biochemistry) , Plasmodium falciparum1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) , South African Natural Compounds Database
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192798 , vital:45265 , 10.21504/10962/192798
- Description: Malaria is a millennia-old disease with the first recorded cases dating back to 2700 BC found in Chinese medical records, and later in other civilizations. It has claimed human lives to such an extent that there are a notable associated socio-economic consequences. Currently, according to the World Health Organization (WHO), Africa holds the highest disease burden with 94% of deaths and 82% of cases with P. falciparum having ~100% prevalence. Chemotherapy, such as artemisinin combination therapy, has been and continues to be the work horse in the fight against the disease, together with seasonal malaria chemoprevention and the use of insecticides. Natural products such as quinine and artemisinin are particularly important in terms of their antimalarial activity. The emphasis in current chemotherapy research is the need for time and cost-effective workflows focussed on new mechanisms of action (MoAs) covering the target candidate profiles (TCPs). Despite a decline in cases over the past decades with, countries increasingly becoming certified malaria free, a stalling trend has been observed in the past five years resulting in missing the 2020 Global Technical Strategy (GTS) milestones. With no effective vaccine, a reduction in funding, slower drug approval than resistance emergence from resistant and invasive vectors, and threats in diagnosis with the pfhrp2/3 gene deletion, malaria remains a major health concern. Motivated by these reasons, the primary aim of this work was a contribution to the antimalarial pipeline through in silico approaches focusing on P. falciparum. We first intended an exploration of malarial targets through a proteome scale screening on 36 targets using multiple metrics to account for the multi-objective nature of drug discovery. The continuous growth of structural data offers the ideal scenario for mining new MoAs covering antimalarials TCPs. This was combined with a repurposing strategy using a set of orally available FDA approved drugs. Further, use was made of time- and cost-effective strategies combining QVina-W efficiency metrics that integrate molecular properties, GRIM rescoring for molecular interactions and a hydrogen mass repartitioning (HMR) molecular dynamics (MD) scheme for accelerated development of antimalarials in the context of resistance. This pipeline further integrates a complex ranking for better drug-target selectivity, and normalization strategies to overcome docking scoring function bias. The different metrics, ranking, normalization strategies and their combinations were first assessed using their mean ranking error (MRE). A version combining all metrics was used to select 36 unique protein-ligand complexes, assessed in MD, with the final retention of 25. From the 16 in vitro tested hits of the 25, fingolimod, abiraterone, prazosin, and terazosin showed antiplasmodial activity with IC50 2.21, 3.37, 16.67 and 34.72 μM respectively and of these, only fingolimod was found to be not safe with respect to human cell viability. These compounds were predicted active on different molecular targets, abiraterone was predicted to interact with a putative liver-stage essential target, hence promising as a transmission-blocking agent. The pipeline had a promising 25% hit rate considering the proteome-scale and use of cost-effective approaches. Secondly, we focused on Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) using a more extensive screening pipeline to overcome some of the current in silico screening limitations. Starting from the ZINC lead-like library of ~3M, hierarchical ligand-based virtual screening (LBVS) and structure-based virtual screening (SBVS) approaches with molecular docking and re-scoring using eleven scoring functions (SFs) were used. Later ranking with an exponential consensus strategy was included. Selected hits were further assessed through Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA), advanced MD sampling in a ligand pulling simulations and (Weighted Histogram Analysis Method) WHAM analysis for umbrella sampling (US) to derive binding free energies. Four leads had better predicted affinities in US than LC5, a 280 nM potent PfDXR inhibitor with ZINC000050633276 showing a promising binding of -20.43 kcal/mol. As shown with fosmidomycin, DXR inhibition offers fast acting compounds fulfilling antimalarials TCP1. Yet, fosmidomycin has a high polarity causing its short half-life and hampering its clinical use. These leads scaffolds are different from fosmidomycin and hence may offer better pharmacokinetic and pharmacodynamic properties and may also be promising for lead optimization. A combined analysis of residues’ contributions to the free energy of binding in MM-PBSA and to steered molecular dynamics (SMD) Fmax indicated GLU233, CYS268, SER270, TRP296, and HIS341 as exploitable for compound optimization. Finally, we updated the SANCDB library with new NPs and their commercially available analogs as a solution to NP availability. The library is extended to 1005 compounds from its initial 600 compounds and the database is integrated to Mcule and Molport APIs for analogs automatic update. The new set may contribute to virtual screening and to antimalarials as the most effective ones have NP origin. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
Baseline description of the Benthic Biotopes for two Long-Term Ecological Research (LTER) stations in Algoa Bay, Agulhas ecoregion, South Africa
- Authors: Parker-Nance, Shirley
- Date: 2021-10-29
- Subjects: Benthic ecology South Africa Algoa Bay , Long-Term Ecological Research Program , Marine invertebrates South Africa Algoa Bay , Reef ecology South Africa Algoa Bay , Coastal zone management South Africa Algoa Bay , Reef fishes South Africa Algoa Bay , Ecological mapping South Africa Algoa Bay
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/191680 , vital:45147 , 10.21504/10962/191680
- Description: Shallow coastal marine ecosystems provide important resources to society but are increasingly under threat from anthropogenic impacts. These systems form an interface between land and sea, providing valuable resources. Global environmental change, overexploitation, habitat transformation, pollution and policies aimed at short-term socio-economic gains are driving the loss of natural resources, productivity and biodiversity. Consequently, a comprehensive and holistic understanding of the current and future states of marine ecosystems is essential. This requires insight into the processes involved in maintaining genetic, species, habitat, community and biotope diversity at an ecosystem level. An understanding of ecosystem processes and the ability to detect changes in biodiversity, biotopes, seascape composition and ecosystem functioning require observation made over time and space. In response to this need, Long-Term Ecological Research (LTER) programmes such as those established by the South African Environmental Observation Network (SAEON) supported by the Department of Science and Innovation’s (DSI) Shallow Marine and Coastal Research Infrastructure (SMCRI) collect long–term observational data from different environments and systems. This study aimed to evaluate data collected as part of the developmental phase of a newly established benthic research platform. The datasets constructed are used to develop a baseline description of the benthic biotopes of two study areas within Algoa Bay. It aimed to gain insight into the feasibility of the methods used and the value of the data and derived essential biological variables (EVB). Assessing the sustainability of the programme over time was done through a practical evaluation of the methodology to be used and the technical feasibility of data collection and analysis. It furthermore aimed to assess the data usefulness in describing biodiversity at various scales and its sensitivity in reporting change. This pilot study provides valuable insight into data collection methodologies and introduces new sampling platforms. The baseline dataset consisted of data collected during the first 18 months of the SAEON Benthic Ecosystem Long-Term Ecological Research (BELTER) platform in Algoa Bay, Agulhas ecoregion, Western Indian Ocean, South Africa. This comprised of the collection of images for 150 m2 of the researched benthic seascape and 306 stereo video data streams. The 77 760 point dataset allowed the identification of 12 substrate types, 7 biotopes, 44 sub-biotope units, 377 sessile and sedentary benthic species and 51 ichthyofauna species. The described habitat and benthic communities and the defined benthic biotopes allowed for the assessment of biotope heterogeneity and the construction of a provisional distribution map for the broader biotopes. This work includes a study into the infra- and supra-benthic ichthyofauna associated with the defined biotopes and investigates the role habitat and benthic communities play in the distribution of these fish 3 assemblages. Lastly, it assesses the value of morphological traits and diversity indices for describing and comparing abiotic and biotic components of observed systems within the shallow coastal marine seascape. This study shows that species composition differs significantly between biotopes with habitat type playing a key role in the composition of the benthos. Substrate type, consolidated or unconsolidated, depth and the composition of the soft sediment is the most important determining factors. The White Sands Reef station has a higher species diversity than the St Croix Island Complex station with a higher percentage cover associated with the hard substrate. The dissimilarity between biotopes and communities are generally high although similarity within the biotopes or communities was found to be relatively low. This was considered indicative of high heterogeneity within the biotopes and a patch or mosaic-like distribution of communities within the broader biotope. A fine-scale a posteriori analysis of the data collected confirmed the high heterogeneous nature of both habitat and communities within the broader biotope. The description of the abiotic and biotic variables resulted in the identification of a diverse suite of biotope subunits. The character of the biotope hinges not only on the composition of the substrate and biota present but the contribution of smaller distinct biotopes subunits, their distribution and representation within broader biotopes and the degree these are shared with other broader biotopes. The distribution of these biotope units at different scales is believed to be important in understanding inherent diversity, niche partitioning and connectivity within a highly heterogeneous seascape. Ichthyofauna associated with the broader biotopes were indicative of the substrate type. Low profile reef systems with interspaced sandy stretches supported both reef fish and those typically associated with sandy substrates. Benthic biotopes associated characteristically with higher profile reef systems and less sand or soft sediment were mainly utilized by reef-associated fish species. Substrate type, depth and seasonality were found to be important factors in the observed composition and distribution of ichthyofauna over the seascape. Although fish species were found to have a wide distribution and made use of multiple biotopes the average abundance of the species within the observed assemblages differed. Analysis of ichthyofauna species composition indicated that observed fish assemblages were homogeneous within five of the seven biotopes. Broader biotopes that were found to be significantly different between sample locations are characterised by a diverse complement of biotope subunits and are highly heterogeneous. Traits and diversity indices are important tools for assessing and comparing different systems within the seascape, both spatially and temporally. The classification of the biota into broader phylogenetic groups indicated a significant difference between biotopes. This is especially useful when detailed 4 analysis or species identification is not possible or the skill set is not available. Morphological traits included in this study informed on the physical structure of the communities present and in combination with substrate type provided insight into the three-dimensional structure of the biotope. Species diversity, abundance, density estimates and the Shannon-Weiner diversity index were found to be the most useful diversity indices characterising and comparing biotopes. This was less so for ichthyofauna. Significant differences in the number of species observed were evident only between consolidated and unconsolidated dominated substrates. Although there was no significant difference in the number of individuals observed, both the Shannon-Weiner and Simpson Diversity indices were able to highlight differences in the fish assemblages observed for the different biotopes. The data collected, although permitting a comprehensive baseline assessment of the benthic environment for two research stations within the SAEON Algoa Bay LTER Sentinel Site, is temporally limited. The ichthyofauna dataset used was small and it is understood that the addition of length-frequency analysis of observed ichthyofauna will benefit our understanding of the biotope use by infra- and supra-benthic fish species over their life history within the larger seascape. Seasonal differences were evident and it is expected that datasets spanning several years, including LTER stations within different marine ecosystems types, will provide valuable insights on system dynamics in the short and long term both spatially and temporally. This study is the first attempt to evaluate the methodology developed and data collected in the South African Environmental Observation Network’s, Elwandle Coastal Node as part of the Shallow Marine and Coastal Research Infrastructure Benthic Ecosystem Long-Term Ecological Research (BELTER) platform. Newly designed and developed sample equipment and a sampling regime allowed for the collection of data on a long-term basis. The study was successful in the description of the biotope and biotope subunits for two research stations in Algoa Bay. It permitted the construction of comprehensive species lists for both benthic sessile and sedentary biota and the associated ichthyofauna. The subset of data used was successful in reporting on both spatial and temporal change. This work demonstrates that in the absence of detailed species identifications, traits may be used to describe habitat and community structure and report on abiotic and biotic biotope characteristics. This study furthermore allowed for the comparison of a comprehensive suite of diversity indices highlighting indices that may be especially useful in routine BELTER reporting. , Thesis (PhD) -- Faculty of Science, Ichthyology and Fisheries Science, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Parker-Nance, Shirley
- Date: 2021-10-29
- Subjects: Benthic ecology South Africa Algoa Bay , Long-Term Ecological Research Program , Marine invertebrates South Africa Algoa Bay , Reef ecology South Africa Algoa Bay , Coastal zone management South Africa Algoa Bay , Reef fishes South Africa Algoa Bay , Ecological mapping South Africa Algoa Bay
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/191680 , vital:45147 , 10.21504/10962/191680
- Description: Shallow coastal marine ecosystems provide important resources to society but are increasingly under threat from anthropogenic impacts. These systems form an interface between land and sea, providing valuable resources. Global environmental change, overexploitation, habitat transformation, pollution and policies aimed at short-term socio-economic gains are driving the loss of natural resources, productivity and biodiversity. Consequently, a comprehensive and holistic understanding of the current and future states of marine ecosystems is essential. This requires insight into the processes involved in maintaining genetic, species, habitat, community and biotope diversity at an ecosystem level. An understanding of ecosystem processes and the ability to detect changes in biodiversity, biotopes, seascape composition and ecosystem functioning require observation made over time and space. In response to this need, Long-Term Ecological Research (LTER) programmes such as those established by the South African Environmental Observation Network (SAEON) supported by the Department of Science and Innovation’s (DSI) Shallow Marine and Coastal Research Infrastructure (SMCRI) collect long–term observational data from different environments and systems. This study aimed to evaluate data collected as part of the developmental phase of a newly established benthic research platform. The datasets constructed are used to develop a baseline description of the benthic biotopes of two study areas within Algoa Bay. It aimed to gain insight into the feasibility of the methods used and the value of the data and derived essential biological variables (EVB). Assessing the sustainability of the programme over time was done through a practical evaluation of the methodology to be used and the technical feasibility of data collection and analysis. It furthermore aimed to assess the data usefulness in describing biodiversity at various scales and its sensitivity in reporting change. This pilot study provides valuable insight into data collection methodologies and introduces new sampling platforms. The baseline dataset consisted of data collected during the first 18 months of the SAEON Benthic Ecosystem Long-Term Ecological Research (BELTER) platform in Algoa Bay, Agulhas ecoregion, Western Indian Ocean, South Africa. This comprised of the collection of images for 150 m2 of the researched benthic seascape and 306 stereo video data streams. The 77 760 point dataset allowed the identification of 12 substrate types, 7 biotopes, 44 sub-biotope units, 377 sessile and sedentary benthic species and 51 ichthyofauna species. The described habitat and benthic communities and the defined benthic biotopes allowed for the assessment of biotope heterogeneity and the construction of a provisional distribution map for the broader biotopes. This work includes a study into the infra- and supra-benthic ichthyofauna associated with the defined biotopes and investigates the role habitat and benthic communities play in the distribution of these fish 3 assemblages. Lastly, it assesses the value of morphological traits and diversity indices for describing and comparing abiotic and biotic components of observed systems within the shallow coastal marine seascape. This study shows that species composition differs significantly between biotopes with habitat type playing a key role in the composition of the benthos. Substrate type, consolidated or unconsolidated, depth and the composition of the soft sediment is the most important determining factors. The White Sands Reef station has a higher species diversity than the St Croix Island Complex station with a higher percentage cover associated with the hard substrate. The dissimilarity between biotopes and communities are generally high although similarity within the biotopes or communities was found to be relatively low. This was considered indicative of high heterogeneity within the biotopes and a patch or mosaic-like distribution of communities within the broader biotope. A fine-scale a posteriori analysis of the data collected confirmed the high heterogeneous nature of both habitat and communities within the broader biotope. The description of the abiotic and biotic variables resulted in the identification of a diverse suite of biotope subunits. The character of the biotope hinges not only on the composition of the substrate and biota present but the contribution of smaller distinct biotopes subunits, their distribution and representation within broader biotopes and the degree these are shared with other broader biotopes. The distribution of these biotope units at different scales is believed to be important in understanding inherent diversity, niche partitioning and connectivity within a highly heterogeneous seascape. Ichthyofauna associated with the broader biotopes were indicative of the substrate type. Low profile reef systems with interspaced sandy stretches supported both reef fish and those typically associated with sandy substrates. Benthic biotopes associated characteristically with higher profile reef systems and less sand or soft sediment were mainly utilized by reef-associated fish species. Substrate type, depth and seasonality were found to be important factors in the observed composition and distribution of ichthyofauna over the seascape. Although fish species were found to have a wide distribution and made use of multiple biotopes the average abundance of the species within the observed assemblages differed. Analysis of ichthyofauna species composition indicated that observed fish assemblages were homogeneous within five of the seven biotopes. Broader biotopes that were found to be significantly different between sample locations are characterised by a diverse complement of biotope subunits and are highly heterogeneous. Traits and diversity indices are important tools for assessing and comparing different systems within the seascape, both spatially and temporally. The classification of the biota into broader phylogenetic groups indicated a significant difference between biotopes. This is especially useful when detailed 4 analysis or species identification is not possible or the skill set is not available. Morphological traits included in this study informed on the physical structure of the communities present and in combination with substrate type provided insight into the three-dimensional structure of the biotope. Species diversity, abundance, density estimates and the Shannon-Weiner diversity index were found to be the most useful diversity indices characterising and comparing biotopes. This was less so for ichthyofauna. Significant differences in the number of species observed were evident only between consolidated and unconsolidated dominated substrates. Although there was no significant difference in the number of individuals observed, both the Shannon-Weiner and Simpson Diversity indices were able to highlight differences in the fish assemblages observed for the different biotopes. The data collected, although permitting a comprehensive baseline assessment of the benthic environment for two research stations within the SAEON Algoa Bay LTER Sentinel Site, is temporally limited. The ichthyofauna dataset used was small and it is understood that the addition of length-frequency analysis of observed ichthyofauna will benefit our understanding of the biotope use by infra- and supra-benthic fish species over their life history within the larger seascape. Seasonal differences were evident and it is expected that datasets spanning several years, including LTER stations within different marine ecosystems types, will provide valuable insights on system dynamics in the short and long term both spatially and temporally. This study is the first attempt to evaluate the methodology developed and data collected in the South African Environmental Observation Network’s, Elwandle Coastal Node as part of the Shallow Marine and Coastal Research Infrastructure Benthic Ecosystem Long-Term Ecological Research (BELTER) platform. Newly designed and developed sample equipment and a sampling regime allowed for the collection of data on a long-term basis. The study was successful in the description of the biotope and biotope subunits for two research stations in Algoa Bay. It permitted the construction of comprehensive species lists for both benthic sessile and sedentary biota and the associated ichthyofauna. The subset of data used was successful in reporting on both spatial and temporal change. This work demonstrates that in the absence of detailed species identifications, traits may be used to describe habitat and community structure and report on abiotic and biotic biotope characteristics. This study furthermore allowed for the comparison of a comprehensive suite of diversity indices highlighting indices that may be especially useful in routine BELTER reporting. , Thesis (PhD) -- Faculty of Science, Ichthyology and Fisheries Science, 2021
- Full Text:
- Date Issued: 2021-10-29
Biton’s Lost Siege Engine: Experimental archaeology in Classical Studies
- Authors: Rademan, David John
- Date: 2021-10-29
- Subjects: Pergamum (Extinct city) , Dimensional analysis , Engineering History To 168 B.C. , Fluid mechanics History To 168 B.C. , Byzantine literature History and criticism , Siege warfare History To 168 B.C. , Biton of Pergamon , Isidorus of Abydos , Poliorcetics
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192330 , vital:45216
- Description: This thesis entails an examination of several problems inherent in placing a technical treatise by the Hellenistic Greek engineer, Biton of Pergamon, at a siege of 156-154BCE, with a view to galvanising the existing case of previous scholarship through a combined approach of literary, textual, geographical, and technical analysis. Particular focus is given to the following problems: technical errors in current translations of the treatise of Biton; technical considerations in scholars’ reproductions of a particular engine in the treatise; an assessment of the practical implications of the treatise in situ at the physical site of the ancient city of Pergamon in the second century BCE, as evidenced by archaeological findings and surveys; assessment of those implications by way of historical records of similar conflicts from the Hellenistic period; and suggesting a procedure of dimensional analysis for testing a hypothesis regarding the feasibility of the ancient engineer’s recommended engines as a stand-in for the city’s original defenses, in a manner that harmonises the methodologies of historicism and experimental archaeology with sound and appropriate modern engineering practice from the field of Fluid Mechanics. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Rademan, David John
- Date: 2021-10-29
- Subjects: Pergamum (Extinct city) , Dimensional analysis , Engineering History To 168 B.C. , Fluid mechanics History To 168 B.C. , Byzantine literature History and criticism , Siege warfare History To 168 B.C. , Biton of Pergamon , Isidorus of Abydos , Poliorcetics
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192330 , vital:45216
- Description: This thesis entails an examination of several problems inherent in placing a technical treatise by the Hellenistic Greek engineer, Biton of Pergamon, at a siege of 156-154BCE, with a view to galvanising the existing case of previous scholarship through a combined approach of literary, textual, geographical, and technical analysis. Particular focus is given to the following problems: technical errors in current translations of the treatise of Biton; technical considerations in scholars’ reproductions of a particular engine in the treatise; an assessment of the practical implications of the treatise in situ at the physical site of the ancient city of Pergamon in the second century BCE, as evidenced by archaeological findings and surveys; assessment of those implications by way of historical records of similar conflicts from the Hellenistic period; and suggesting a procedure of dimensional analysis for testing a hypothesis regarding the feasibility of the ancient engineer’s recommended engines as a stand-in for the city’s original defenses, in a manner that harmonises the methodologies of historicism and experimental archaeology with sound and appropriate modern engineering practice from the field of Fluid Mechanics. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-10-29
Cellphones and whistles: Exploring the communicative ecology and sociality of the Enkanini informal settlement in Makhanda
- Authors: Baloyi, Karabo
- Date: 2021-10-29
- Subjects: Communication models , Cell phones Social aspects South Africa Makhanda , Cell phones Economic aspects South Africa Makhanda , Squatter settlements South Africa Makhanda , South Africa Social conditions 1994- , South Africa Economic conditions 1991- , South Africa Social life and customs , Communication Economic aspects South Africa Makhanda , Whistles South Africa Makhanda , Decolonization South Africa Makhanda , Communicative ecology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191046 , vital:45053
- Description: This thesis explores the communicative ecology in the Enkanini informal settlement in Makhanda, and in particular their use of mobile phones and whistles to build a sense of community. It makes the case for word-of-mouth as an integral part of the communicative ecology despite not being a technological device. It then examines the sociality that arises from the use of these devices, and how coloniality impacts on the participants’ everyday experiences. The research was conducted through telephonic in-depth interviews with participants. To corroborate some of the content drawn from interviews, I used Grocott’s Mail, Makhanda’s only independent newspaper as an archival source, as well as some of the participants’ Facebook profiles. This research argues that as a consequence of coloniality, Enkanini’s residents suffer socio-economic challenges, and thus are unable to use digital technologies as much as they might like to, to communicate with their neighbours. As a consequence, word-of-mouth is their main form of communication with one another. Whistles are the ‘low-tech’ device used for community-wide communication to alert residents of an emergency, or about a meeting or protest. My findings contest generalised claims of society moving towards a network sociality, where individuality and project-based communication is valued over more communal forms of living. They also demonstrate the ways in which coloniality shapes almost every aspect of marginalised people’s lives, making word of mouth the most significant form of communication, notwithstanding the apparent availability of digital technology. It also shows how a marginalised group uses the resources it has to pressure local government officials to provide them with the basis infrastructure they need for survival. , Thesis (MA) -- Faculty of Humanities, Journalism and Media Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Baloyi, Karabo
- Date: 2021-10-29
- Subjects: Communication models , Cell phones Social aspects South Africa Makhanda , Cell phones Economic aspects South Africa Makhanda , Squatter settlements South Africa Makhanda , South Africa Social conditions 1994- , South Africa Economic conditions 1991- , South Africa Social life and customs , Communication Economic aspects South Africa Makhanda , Whistles South Africa Makhanda , Decolonization South Africa Makhanda , Communicative ecology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191046 , vital:45053
- Description: This thesis explores the communicative ecology in the Enkanini informal settlement in Makhanda, and in particular their use of mobile phones and whistles to build a sense of community. It makes the case for word-of-mouth as an integral part of the communicative ecology despite not being a technological device. It then examines the sociality that arises from the use of these devices, and how coloniality impacts on the participants’ everyday experiences. The research was conducted through telephonic in-depth interviews with participants. To corroborate some of the content drawn from interviews, I used Grocott’s Mail, Makhanda’s only independent newspaper as an archival source, as well as some of the participants’ Facebook profiles. This research argues that as a consequence of coloniality, Enkanini’s residents suffer socio-economic challenges, and thus are unable to use digital technologies as much as they might like to, to communicate with their neighbours. As a consequence, word-of-mouth is their main form of communication with one another. Whistles are the ‘low-tech’ device used for community-wide communication to alert residents of an emergency, or about a meeting or protest. My findings contest generalised claims of society moving towards a network sociality, where individuality and project-based communication is valued over more communal forms of living. They also demonstrate the ways in which coloniality shapes almost every aspect of marginalised people’s lives, making word of mouth the most significant form of communication, notwithstanding the apparent availability of digital technology. It also shows how a marginalised group uses the resources it has to pressure local government officials to provide them with the basis infrastructure they need for survival. , Thesis (MA) -- Faculty of Humanities, Journalism and Media Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
Climate change and small-scale farmer livelihood adaptation in rural border communities in Southern Africa: A case study of Ezondweni Village in Mchinji, Malawi
- Authors: Simango, Kennedy Khuzwayo
- Date: 2021-10-29
- Subjects: Farms, Small Malawi Mchinji , Climatic changes Economic aspects Malawi Mchinji , Climatic changes Risk management Malawi Mchinji , Crops and climate Malawi Mchinji , Sustainable agriculture Malawi Mchinji , Farmers Social networks Malawi Mchinji , Farm income Malawi Mchinji
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190008 , vital:44955
- Description: Southern Africa is a region increasingly experiencing the detrimental effects of climate change and variability. The rural areas in particular face unprecedented climate change-induced challenges in relation to small-scale farmers being able to pursue household-based livelihoods, and these farmers seek ways of adapting to climate change and variability in doing so. Some rural communities exist along territorial borders and their attempts at adapting to climate change entails cross-border networks and activities. In this context, this thesis examines small-scale farmer adaptation to climate change and variability in the small village of Ezondweni in Malawi near the Zambian border. Analytically, the study draws upon the Sustainable Livelihoods Framework as well as social network theory and the theory of reflexive agency put forward by Margaret Archer. A qualitative research design entailed informal interviews with a small number of Ezondweni villagers, focusing on their perceptions of climate change and their practices of climate change adaptation. The study demonstrates the diverse activities pursued by villagers, both within Malawi and beyond, in seeking to maintain household-based livelihoods, as well as the significance of mutually-supportive social networks which facilitate these livelihood processes. , Thesis (MSocSci) -- Faculty of Humanities, Social Science, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Simango, Kennedy Khuzwayo
- Date: 2021-10-29
- Subjects: Farms, Small Malawi Mchinji , Climatic changes Economic aspects Malawi Mchinji , Climatic changes Risk management Malawi Mchinji , Crops and climate Malawi Mchinji , Sustainable agriculture Malawi Mchinji , Farmers Social networks Malawi Mchinji , Farm income Malawi Mchinji
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190008 , vital:44955
- Description: Southern Africa is a region increasingly experiencing the detrimental effects of climate change and variability. The rural areas in particular face unprecedented climate change-induced challenges in relation to small-scale farmers being able to pursue household-based livelihoods, and these farmers seek ways of adapting to climate change and variability in doing so. Some rural communities exist along territorial borders and their attempts at adapting to climate change entails cross-border networks and activities. In this context, this thesis examines small-scale farmer adaptation to climate change and variability in the small village of Ezondweni in Malawi near the Zambian border. Analytically, the study draws upon the Sustainable Livelihoods Framework as well as social network theory and the theory of reflexive agency put forward by Margaret Archer. A qualitative research design entailed informal interviews with a small number of Ezondweni villagers, focusing on their perceptions of climate change and their practices of climate change adaptation. The study demonstrates the diverse activities pursued by villagers, both within Malawi and beyond, in seeking to maintain household-based livelihoods, as well as the significance of mutually-supportive social networks which facilitate these livelihood processes. , Thesis (MSocSci) -- Faculty of Humanities, Social Science, 2021
- Full Text:
- Date Issued: 2021-10-29
Climate for changing lenses: Reconciliation through site-specific, media arts-based environmental education on the water and climate change nexus in South Africa and Canada
- Authors: Van Borek, Sarah
- Date: 2021-10-29
- Subjects: Environmental education South Africa , Environmental education Canada , Climatic changes in art , Water-supply Climatic factors , Decolonization , Reconciliation South Africa , Curriculum change , Traditional ecological knowledge
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192754 , vital:45260 , 10.21504/10962/192754
- Description: This study took place in the context of a growing racialised global water crisis and increasing demands worldwide for transforming higher education at institutions of ongoing settler colonialism. It presents a conceptualisation of what education, research and activism can look like and unfolded inside a doctoral research project that expands what doctoral education can look like. Using a media arts-based praxis process, I developed a relational model of university curriculum –site-specific, media arts-based, environmental education –with potential to cultivate relations (human and nonhuman) towards reconciliation while contributing to justice at the water-climate change nexus. My aim as a settler-ally was to expand my teaching and curriculum practices, thereby also offering curriculum transformation inspiration to others. My research was rooted in my concept of reconciliation as a practice towards thriving together, where the ‘together’ was inclusive of both humans and nonhumans. The curriculum engaged students in de/re/constructing water narratives through making site-specific videos focused on local water bodies. Decolonising artistic approaches known as slow media and soundscape recording were strategically incorporated into audio/video mapping assignments where students observed water aesthetics in ways that shifted their perceptions about water and entities entangled with it. Students met with Knowledge Keepers (Indigenous and non-Indigenous people from outside the academy with existing relationships to water bodies). A photovoice methodology was used in these meetings with Knowledge Keepers to reconfigure traditional film director-subject power relations. Guest lecturers from non-traditional backgrounds contributed diverse perspectives. Ecomotricity was incorporated, whereby students were in deliberate movement in/with water bodies through canoeing together. The curriculum culminated in a public screening/education event where resulting videos, interspersed with educational games facilitated by students, surfaced emotions, knowledge co-production and new synergies amongst the event’s temporary community. Through two iterations of the curriculum, where I co-designed and taught a course called Making Waveforms, one in Vancouver, Canada and one in Cape Town, South Africa, I explored the primary research question: How can a relational site specific, media arts-based university environmental education curriculum cultivate students’ relational sensibilities and abilities oriented towards reconciliation of diverse peoples and ecosystems in South Africa and Canada? Iterating the curriculum across these two contexts allowed me to assess which aspect(s)of the curriculum may have been applicable across these and other contexts. By using mixed methods of data collection and sharing throughout the research journey, I explored the sub-questions: a) How is reconciliation understood currently by university students in South Africa and Canada? and b) How can a relational site-specific, media arts-based university environmental education curriculum and my PhD methodologies (PhD-by-publication, website, and participatory approaches to podcasting, video making, and song creation), contribute to decolonising higher education, and thereby further contribute to reconciliation of diverse peoples and ecosystems in South Africa and Canada? Integral to my praxis process, I undertook a PhD-by-publication that involved writing four academic journal articles, with each paper presenting a key stage in the process. The papers, all of which have been submitted to peer-reviewed academic journals, form part of this thesis and can be found in the Appendices. The course was originally developed around Donati’s (2011) relational sociology and Gergen’s (2009) relational education theory. Throughout my praxis process, I expanded my theoretical influences as called for by the research and teaching practice. The journey behind my first PhD paper, (Towards) Sound research practice: Podcast-building as modeling relational sensibilities at the water-climate change nexus in Cape Town, began when I officially started my doctoral studies in early 2018. The paper was co-authored with a fellow PhD scholar from Rhodes University’s Environmental Learning Research Centre (ELRC), Anna James. It presents an experimental arts-based methodology we co-developed for doing contextual profiling by building a socially-engaged podcast series, called Day One, to explore the lived experiences of the Cape Town water crisis of 2018. It includes my initial tool of analysis for exploring how the curriculum might cultivate relational sensibilities and abilities towards reconciliation. The podcast pedagogy offered opportunities to develop some relational learning processes. The analytical tool was developed from cross-referencing reconciliation and relational educational theories. This paper also incorporated theories in relational solidarity and social movement learning. The podcast episodes included personal narratives that, in turn, revealed diverse ideologies and polarisations in the water situation. Working with the audio medium highlighted possibilities for creating and shifting affective relations. Recording and editing soundscapes of waterbodies began explorations of the agential qualities of water. These were foundational dynamics to explore in building the reconciliation curriculum. The paper is published in the International Journal of New Media, Technology, and the Arts (2019, Volume14, Issue1). My second PhD paper, A media arts-based praxis process of building towards a relational model of curriculum oriented towards reconciliation through water justice, presents my methodology for and analysis of a pilot course I co-designed and taught at the Emily Carr University of Art + Design (ECUAD) in Vancouver, Canada in 2018. This course served as contextual profiling around the water situation in Vancouver. The course was offered in partnership with a science-based environmental non-profit called the David Suzuki Foundation and an Indigenous-led post-secondary school called the Native Education College. The course’s public event was hosted at the Beaty Biodiversity Museum. At this stage, I was introduced to Cree/Métis filmmaker, Gregory Coyes, and his Indigenous cinematic narrative approach known as Slow Media. Integrating slow media into video mapping assignments presented exciting possibilities for shifting views and valuing of water. This was the stage at which my concept of reconciliation expanded to explicitly include nonhumans. I applied my initial analytical tool to the curriculum here, which revealed the three most prominent relational sensibilities and abilities towards reconciliation cultivated by students through the course: (1) knowledge ecologies; (2) a hopeful social imaginary; and (3) embodied ways of knowing. I began to make connections between the curriculum and Mi’kmaq elder Albert Marshall’s concept of ‘Two-Eyed-Seeing’, and expanded the notion to ‘Three-Eyed-Seeing’ to include artistic approaches. Deeply inspired by Bekerman and Zembylas’s (2012) Teaching Contested Narratives, I began to see the growing importance of the narrative aspects of reconciliation education. The paper is published in the University of Pretoria’s Journal of Decolonising Disciplines (2021, Volume 1, Issue 2). My third PhD paper, Water as artist-collaborator: Posthumanism and reconciliation in relational media arts-based education, presents a 2019 iteration of the curriculum at ECUAD in Vancouver, and illustrates my shift to include posthuman theories in my analysis. This course was offered in affiliation with the David Suzuki Foundation, and in collaboration with the Native Education College. The culminating public event was hosted by the Beaty Biodiversity Museum. Decentring the human in this data analysis better supported my research and curricular aims. The strong technoculture of the media arts-based curriculum fits well with many posthuman concepts. This posthuman reading of the course and data enabled me to see what changes were emerging through student-water-technology intra-actions, and how these supported relations towards reconciliation as well as water justice. Most notable of these changes was the emergence of water’s agential qualities, specifically of water as becoming collaborator in artistic/knowledge co-production, where students think with water. I argued this contributes to reconciliation by decentring the human, enabling relations in which power is more equal, and where there are greater possibilities for mutual responsibility between related entities. This is where I developed the concept of audio/video as relational texts, supporting the creating and shifting of affective relations more than the monumentalised verbal/written knowledge of traditional universities. This is also where I realised that relational work towards reconciliation would require engaging with the hidden curriculum of institutions. The paper is published in the journal Reconceptualizing Educational Research Methodology (2021, Volume 12, Issue 1), as part of a special issue on Posthuman Conceptions of Change in Empirical Educational Research. My fourth PhD paper, originally entitled Making waveforms: Implicit knowledge representation through video water narratives as decolonising practice towards reconciliation in South Africa’s higher education, presents an analysis of the 2019 iteration of the curriculum in South Africa. I co-designed and led a course called Making Waveforms at the University of Cape Town’s Future Water Institute (FWI) in collaboration with Rhodes University. The course was co-designed/facilitated with FWI’s Research Fellow Amber Abrams, who also co-authored this paper. The course’s public event was hosted by a non-profit organisation called the Tshisimani Centre for Activist Education. This paper explored the ways that non-verbalisable, implicit learning –understood as part of many non-Euro/Western ways of knowing– takes place in the Making Waveforms course and how this influenced water-specific climate behaviours while contributing to decolonised reconciliation practice for higher education institutions. Drawing on theories of implicit and explicit knowledge, we first showed how implicit learning primarily took place through: 1) site-specific audio/video mapping of water bodies; 2) meetings with Knowledge Keepers; and 3) an interactive public screening event. We highlighted how this non-verbalisable learning produced feelings of empathy for diverse peoples and waterways, as well as aesthetic appreciation of water, and how this can contribute to more response-able water behaviours. This, we argued, supported the valuing of implicit knowledge within a traditional educational setting, thereby pluralising knowledge, and was key to reconciliation/decolonisation in higher education. Iterating the curriculum for the South African context emphasised the importance of context-specificity of the course overall, and also of the relational work embedded in the curriculum. This paper is under review by the University of Toronto’s journal Curriculum Inquiry (CI). Following receipt of CI's internal review process, the title of the paper has since been updated to Non-verbalisable, implicit knowledge through cellphilms as decolonised reconciliation practice towards response-able water behaviours in South Africa. Through reflective analysis of my four papers, I developed a concept for an Anatomy of Decoloniz/sed Curriculum consisting of five key parts: 1) relationality; 2) multimodality; 3) narratives/counter-narratives; 4) context-specificity; and 5) unhidden curriculum. Four meta reflections have been included in this thesis, each corresponding with one of the four papers, and presented chronologically according to the stage of the praxis process with which they correspond. In these meta reflections, I applied Kolb’s (1984) Experiential Learning Cycle model for reflective writing, based on the premise that through experiences we can expand our understanding, and included four key stages: 1) concrete experience; 2) reflective observation; 3) abstract conceptualisation; and 4) active experimentation. For the concrete experience, I provided a thick description of my process in writing the paper, as well as aspects of the phase in my praxis process that was the focus of the paper, not included in but relevant to the paper. For the reflective observation, I identified any aspects of the experience that were new to me and which therefore presented opportunities for me to learn. For the abstract conceptualisation, I critically analysed my concrete experience and reflective observation to determine which, if any, of the five key parts of the Anatomy of Decoloniz/sed Curriculum that I outline in my introduction relate to this phase of my PhD praxis process. For the active experimentation, I made conclusions about the extent to which this phase of my PhD embraced decoloniality in practice, and built on this new understanding to make recommendations for myself and others committed to the decolonial project as part of my contribution to knowledge. These meta reflections also invite readers to follow my personal narrative of becoming-with water, meaning my transformation from being water illiterate to embracing a ‘watershed mind’ (Wong,2011). Multimodality, which I propose as a key part of an Anatomy of Decoloniz/sed Curriculum, is embedded in the representational aspects of this thesis. The courses I co-designed and taught as part of this project resulted in the creation of 20 short student films. My contextual profiling involved a podcast methodology that was ongoing throughout my study, as a model of decolonised research-communication-education-action at the water-climate change nexus. This methodology resulted in the creation of four Day One podcast episodes, co-produced with a PhD colleague, Anna James. Some of these episodes are available in all three main languages of Cape Town (Xhosa, Afrikaans, and English). I evolved the podcast methodology in a later stage of my praxis process as a form of member checking with contributors involved in various stages and aspects of the research. Once the four papers were written, I created a series of four short videos called In the Flow, with each video representing a translation of one of the four papers. I invited various contributors of the research project to either watch one or more of the In the Flow videos and/or read one or more of the academic papers, and then to respond in a Zoom call with me. The responses were then shared publicly in a series of seven Climate for Changing Lenses podcast episodes. Parts of these are included in a final song/music video called Please Don’t Blow It. A Climate for Changing Lenses website was created to host all of this multimedia content that forms part of this thesis. A link to this website is provided in the Introduction section of this thesis. My research contributes to the advancement of knowledge in the areas of relational and reconciliation pedagogy, decolonising higher education, arts-based teaching, learning and research methodologies and the water-climate change nexus. My praxis process provided a relational model of reconciliation curriculum that has been tried and tested in two international contexts: Canada and South Africa. , Thesis (PhD) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Van Borek, Sarah
- Date: 2021-10-29
- Subjects: Environmental education South Africa , Environmental education Canada , Climatic changes in art , Water-supply Climatic factors , Decolonization , Reconciliation South Africa , Curriculum change , Traditional ecological knowledge
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192754 , vital:45260 , 10.21504/10962/192754
- Description: This study took place in the context of a growing racialised global water crisis and increasing demands worldwide for transforming higher education at institutions of ongoing settler colonialism. It presents a conceptualisation of what education, research and activism can look like and unfolded inside a doctoral research project that expands what doctoral education can look like. Using a media arts-based praxis process, I developed a relational model of university curriculum –site-specific, media arts-based, environmental education –with potential to cultivate relations (human and nonhuman) towards reconciliation while contributing to justice at the water-climate change nexus. My aim as a settler-ally was to expand my teaching and curriculum practices, thereby also offering curriculum transformation inspiration to others. My research was rooted in my concept of reconciliation as a practice towards thriving together, where the ‘together’ was inclusive of both humans and nonhumans. The curriculum engaged students in de/re/constructing water narratives through making site-specific videos focused on local water bodies. Decolonising artistic approaches known as slow media and soundscape recording were strategically incorporated into audio/video mapping assignments where students observed water aesthetics in ways that shifted their perceptions about water and entities entangled with it. Students met with Knowledge Keepers (Indigenous and non-Indigenous people from outside the academy with existing relationships to water bodies). A photovoice methodology was used in these meetings with Knowledge Keepers to reconfigure traditional film director-subject power relations. Guest lecturers from non-traditional backgrounds contributed diverse perspectives. Ecomotricity was incorporated, whereby students were in deliberate movement in/with water bodies through canoeing together. The curriculum culminated in a public screening/education event where resulting videos, interspersed with educational games facilitated by students, surfaced emotions, knowledge co-production and new synergies amongst the event’s temporary community. Through two iterations of the curriculum, where I co-designed and taught a course called Making Waveforms, one in Vancouver, Canada and one in Cape Town, South Africa, I explored the primary research question: How can a relational site specific, media arts-based university environmental education curriculum cultivate students’ relational sensibilities and abilities oriented towards reconciliation of diverse peoples and ecosystems in South Africa and Canada? Iterating the curriculum across these two contexts allowed me to assess which aspect(s)of the curriculum may have been applicable across these and other contexts. By using mixed methods of data collection and sharing throughout the research journey, I explored the sub-questions: a) How is reconciliation understood currently by university students in South Africa and Canada? and b) How can a relational site-specific, media arts-based university environmental education curriculum and my PhD methodologies (PhD-by-publication, website, and participatory approaches to podcasting, video making, and song creation), contribute to decolonising higher education, and thereby further contribute to reconciliation of diverse peoples and ecosystems in South Africa and Canada? Integral to my praxis process, I undertook a PhD-by-publication that involved writing four academic journal articles, with each paper presenting a key stage in the process. The papers, all of which have been submitted to peer-reviewed academic journals, form part of this thesis and can be found in the Appendices. The course was originally developed around Donati’s (2011) relational sociology and Gergen’s (2009) relational education theory. Throughout my praxis process, I expanded my theoretical influences as called for by the research and teaching practice. The journey behind my first PhD paper, (Towards) Sound research practice: Podcast-building as modeling relational sensibilities at the water-climate change nexus in Cape Town, began when I officially started my doctoral studies in early 2018. The paper was co-authored with a fellow PhD scholar from Rhodes University’s Environmental Learning Research Centre (ELRC), Anna James. It presents an experimental arts-based methodology we co-developed for doing contextual profiling by building a socially-engaged podcast series, called Day One, to explore the lived experiences of the Cape Town water crisis of 2018. It includes my initial tool of analysis for exploring how the curriculum might cultivate relational sensibilities and abilities towards reconciliation. The podcast pedagogy offered opportunities to develop some relational learning processes. The analytical tool was developed from cross-referencing reconciliation and relational educational theories. This paper also incorporated theories in relational solidarity and social movement learning. The podcast episodes included personal narratives that, in turn, revealed diverse ideologies and polarisations in the water situation. Working with the audio medium highlighted possibilities for creating and shifting affective relations. Recording and editing soundscapes of waterbodies began explorations of the agential qualities of water. These were foundational dynamics to explore in building the reconciliation curriculum. The paper is published in the International Journal of New Media, Technology, and the Arts (2019, Volume14, Issue1). My second PhD paper, A media arts-based praxis process of building towards a relational model of curriculum oriented towards reconciliation through water justice, presents my methodology for and analysis of a pilot course I co-designed and taught at the Emily Carr University of Art + Design (ECUAD) in Vancouver, Canada in 2018. This course served as contextual profiling around the water situation in Vancouver. The course was offered in partnership with a science-based environmental non-profit called the David Suzuki Foundation and an Indigenous-led post-secondary school called the Native Education College. The course’s public event was hosted at the Beaty Biodiversity Museum. At this stage, I was introduced to Cree/Métis filmmaker, Gregory Coyes, and his Indigenous cinematic narrative approach known as Slow Media. Integrating slow media into video mapping assignments presented exciting possibilities for shifting views and valuing of water. This was the stage at which my concept of reconciliation expanded to explicitly include nonhumans. I applied my initial analytical tool to the curriculum here, which revealed the three most prominent relational sensibilities and abilities towards reconciliation cultivated by students through the course: (1) knowledge ecologies; (2) a hopeful social imaginary; and (3) embodied ways of knowing. I began to make connections between the curriculum and Mi’kmaq elder Albert Marshall’s concept of ‘Two-Eyed-Seeing’, and expanded the notion to ‘Three-Eyed-Seeing’ to include artistic approaches. Deeply inspired by Bekerman and Zembylas’s (2012) Teaching Contested Narratives, I began to see the growing importance of the narrative aspects of reconciliation education. The paper is published in the University of Pretoria’s Journal of Decolonising Disciplines (2021, Volume 1, Issue 2). My third PhD paper, Water as artist-collaborator: Posthumanism and reconciliation in relational media arts-based education, presents a 2019 iteration of the curriculum at ECUAD in Vancouver, and illustrates my shift to include posthuman theories in my analysis. This course was offered in affiliation with the David Suzuki Foundation, and in collaboration with the Native Education College. The culminating public event was hosted by the Beaty Biodiversity Museum. Decentring the human in this data analysis better supported my research and curricular aims. The strong technoculture of the media arts-based curriculum fits well with many posthuman concepts. This posthuman reading of the course and data enabled me to see what changes were emerging through student-water-technology intra-actions, and how these supported relations towards reconciliation as well as water justice. Most notable of these changes was the emergence of water’s agential qualities, specifically of water as becoming collaborator in artistic/knowledge co-production, where students think with water. I argued this contributes to reconciliation by decentring the human, enabling relations in which power is more equal, and where there are greater possibilities for mutual responsibility between related entities. This is where I developed the concept of audio/video as relational texts, supporting the creating and shifting of affective relations more than the monumentalised verbal/written knowledge of traditional universities. This is also where I realised that relational work towards reconciliation would require engaging with the hidden curriculum of institutions. The paper is published in the journal Reconceptualizing Educational Research Methodology (2021, Volume 12, Issue 1), as part of a special issue on Posthuman Conceptions of Change in Empirical Educational Research. My fourth PhD paper, originally entitled Making waveforms: Implicit knowledge representation through video water narratives as decolonising practice towards reconciliation in South Africa’s higher education, presents an analysis of the 2019 iteration of the curriculum in South Africa. I co-designed and led a course called Making Waveforms at the University of Cape Town’s Future Water Institute (FWI) in collaboration with Rhodes University. The course was co-designed/facilitated with FWI’s Research Fellow Amber Abrams, who also co-authored this paper. The course’s public event was hosted by a non-profit organisation called the Tshisimani Centre for Activist Education. This paper explored the ways that non-verbalisable, implicit learning –understood as part of many non-Euro/Western ways of knowing– takes place in the Making Waveforms course and how this influenced water-specific climate behaviours while contributing to decolonised reconciliation practice for higher education institutions. Drawing on theories of implicit and explicit knowledge, we first showed how implicit learning primarily took place through: 1) site-specific audio/video mapping of water bodies; 2) meetings with Knowledge Keepers; and 3) an interactive public screening event. We highlighted how this non-verbalisable learning produced feelings of empathy for diverse peoples and waterways, as well as aesthetic appreciation of water, and how this can contribute to more response-able water behaviours. This, we argued, supported the valuing of implicit knowledge within a traditional educational setting, thereby pluralising knowledge, and was key to reconciliation/decolonisation in higher education. Iterating the curriculum for the South African context emphasised the importance of context-specificity of the course overall, and also of the relational work embedded in the curriculum. This paper is under review by the University of Toronto’s journal Curriculum Inquiry (CI). Following receipt of CI's internal review process, the title of the paper has since been updated to Non-verbalisable, implicit knowledge through cellphilms as decolonised reconciliation practice towards response-able water behaviours in South Africa. Through reflective analysis of my four papers, I developed a concept for an Anatomy of Decoloniz/sed Curriculum consisting of five key parts: 1) relationality; 2) multimodality; 3) narratives/counter-narratives; 4) context-specificity; and 5) unhidden curriculum. Four meta reflections have been included in this thesis, each corresponding with one of the four papers, and presented chronologically according to the stage of the praxis process with which they correspond. In these meta reflections, I applied Kolb’s (1984) Experiential Learning Cycle model for reflective writing, based on the premise that through experiences we can expand our understanding, and included four key stages: 1) concrete experience; 2) reflective observation; 3) abstract conceptualisation; and 4) active experimentation. For the concrete experience, I provided a thick description of my process in writing the paper, as well as aspects of the phase in my praxis process that was the focus of the paper, not included in but relevant to the paper. For the reflective observation, I identified any aspects of the experience that were new to me and which therefore presented opportunities for me to learn. For the abstract conceptualisation, I critically analysed my concrete experience and reflective observation to determine which, if any, of the five key parts of the Anatomy of Decoloniz/sed Curriculum that I outline in my introduction relate to this phase of my PhD praxis process. For the active experimentation, I made conclusions about the extent to which this phase of my PhD embraced decoloniality in practice, and built on this new understanding to make recommendations for myself and others committed to the decolonial project as part of my contribution to knowledge. These meta reflections also invite readers to follow my personal narrative of becoming-with water, meaning my transformation from being water illiterate to embracing a ‘watershed mind’ (Wong,2011). Multimodality, which I propose as a key part of an Anatomy of Decoloniz/sed Curriculum, is embedded in the representational aspects of this thesis. The courses I co-designed and taught as part of this project resulted in the creation of 20 short student films. My contextual profiling involved a podcast methodology that was ongoing throughout my study, as a model of decolonised research-communication-education-action at the water-climate change nexus. This methodology resulted in the creation of four Day One podcast episodes, co-produced with a PhD colleague, Anna James. Some of these episodes are available in all three main languages of Cape Town (Xhosa, Afrikaans, and English). I evolved the podcast methodology in a later stage of my praxis process as a form of member checking with contributors involved in various stages and aspects of the research. Once the four papers were written, I created a series of four short videos called In the Flow, with each video representing a translation of one of the four papers. I invited various contributors of the research project to either watch one or more of the In the Flow videos and/or read one or more of the academic papers, and then to respond in a Zoom call with me. The responses were then shared publicly in a series of seven Climate for Changing Lenses podcast episodes. Parts of these are included in a final song/music video called Please Don’t Blow It. A Climate for Changing Lenses website was created to host all of this multimedia content that forms part of this thesis. A link to this website is provided in the Introduction section of this thesis. My research contributes to the advancement of knowledge in the areas of relational and reconciliation pedagogy, decolonising higher education, arts-based teaching, learning and research methodologies and the water-climate change nexus. My praxis process provided a relational model of reconciliation curriculum that has been tried and tested in two international contexts: Canada and South Africa. , Thesis (PhD) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-10-29
Concerning Marya Schechtman’s narrative account
- Authors: Simuja, Clement
- Date: 2021-10-29
- Subjects: Schechtman, Marya, 1960- Criticism and interpretation , Narrative inquiry (Research method) , Identity (Psychology) , Identity (Philosophical concept) , Self , Individuality
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190748 , vital:45024
- Description: The persistence of personal identity stands at the heart of many human practices, such as paying individuals for their work or holding people responsible for their actions. As such, it seems important that theories of personal identity are able to account for the practical implications of continuity of personal identity. Mindful of the practical importance of personal identity, Marya Schechtman (1994) argues that her narrative view only accounts for the four features that persons must possess. Any account of personal identity is supposed to make persons capable of possessing these features. She then posits her narrative self-constitution view as an account of personal identity she feels is capable of explaining the link between personal identity and certain features of persons. In this thesis project, I present how the narrative views, as described by Schechtman and others, are interpretive enterprises and that this leads them to a potentially devastating conclusion. The narratives must be constructed from something, and I argue that it is memory. But empirical facts about memory do not allow for it to persist in a quantitative way, but rather in a qualitative way, much like persons. Upon making this argument, I further argue that if mainstream psychological views is correct, this reduces the persistence of memory to resemblance relations. And memory is the building blocks of narrative. If this is the case, then narrative is also reduced to resemblance relations. Narrative, therefore, does not persist through time in a non-qualitative way, and one is better off accepting a psychological theory by virtue of parsimony. Ultimately, I argue that Schechtman and narrative theorists may save narrative views by adopting what I call as a ‘causal narrative view’. A causal narrative view will encapsulate all of the relevant features of the typical narrative view, including the emphasis on construction, but will also add the addendum that narrative states must be placed in a causal relation to each other. , Thesis (MA) -- Faculty of Humanities, Philosophy, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Simuja, Clement
- Date: 2021-10-29
- Subjects: Schechtman, Marya, 1960- Criticism and interpretation , Narrative inquiry (Research method) , Identity (Psychology) , Identity (Philosophical concept) , Self , Individuality
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190748 , vital:45024
- Description: The persistence of personal identity stands at the heart of many human practices, such as paying individuals for their work or holding people responsible for their actions. As such, it seems important that theories of personal identity are able to account for the practical implications of continuity of personal identity. Mindful of the practical importance of personal identity, Marya Schechtman (1994) argues that her narrative view only accounts for the four features that persons must possess. Any account of personal identity is supposed to make persons capable of possessing these features. She then posits her narrative self-constitution view as an account of personal identity she feels is capable of explaining the link between personal identity and certain features of persons. In this thesis project, I present how the narrative views, as described by Schechtman and others, are interpretive enterprises and that this leads them to a potentially devastating conclusion. The narratives must be constructed from something, and I argue that it is memory. But empirical facts about memory do not allow for it to persist in a quantitative way, but rather in a qualitative way, much like persons. Upon making this argument, I further argue that if mainstream psychological views is correct, this reduces the persistence of memory to resemblance relations. And memory is the building blocks of narrative. If this is the case, then narrative is also reduced to resemblance relations. Narrative, therefore, does not persist through time in a non-qualitative way, and one is better off accepting a psychological theory by virtue of parsimony. Ultimately, I argue that Schechtman and narrative theorists may save narrative views by adopting what I call as a ‘causal narrative view’. A causal narrative view will encapsulate all of the relevant features of the typical narrative view, including the emphasis on construction, but will also add the addendum that narrative states must be placed in a causal relation to each other. , Thesis (MA) -- Faculty of Humanities, Philosophy, 2021
- Full Text:
- Date Issued: 2021-10-29
Constraints and enablements on quality improvement in higher education
- Authors: Browning, Leanne Elizabeth
- Date: 2021-10-29
- Subjects: Education, Higher Aims and objectives South Africa , Education, Higher Evaluation , Quality assurance South Africa , Educational evaluation South Africa , Self-evaluation , Critical realism
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/294956 , vital:57273 , DOI 10.21504/10962/294956
- Description: This study contributes to the literature on quality improvement in higher education by examining the structural, cultural and agential constraints and enablements on a quality process at a university in South Africa. It examined four cases and developed an understanding of the complex interaction of structure, culture and agency and the mechanisms that enable or constrain quality improvement in higher education. The study drew on the literature on higher education quality for the theoretical basis for what is known contributes to the way in which quality assurance and improvement is implemented and its impact on the higher education context. Critical Realism provided the ontological framework and conceptual tools to understand and explore the complex social world within which the quality process took place. The literature on the morphogenetic approach provided the analytical framework for the data analysis and findings. The data consisted of a set of documents from a quality process that took place over a five-year period. The data analysis revealed that different departmental contexts impact on how mechanisms are activated. Each school context shapes the way in which people engage with the review process and consequently, processes and procedures are mediated in each context. This research therefore adds to the understanding of the way in which quality processes take place at a micro-level within an institutional context and informs the approach to quality improvement more broadly, nationally and internationally. The research contributes to the knowledge that will inform planning, policies and practices in quality improvement processes in higher education and the findings identify a number of factors (mechanisms) that should inform the way in which a quality process is facilitated, will enable effective self-evaluation and review processes, and consequently are more likely to lead to quality improvement. , Thesis (PhD) -- Faculty of Education, Centre for Higher Education Research, Teaching and Learning, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Browning, Leanne Elizabeth
- Date: 2021-10-29
- Subjects: Education, Higher Aims and objectives South Africa , Education, Higher Evaluation , Quality assurance South Africa , Educational evaluation South Africa , Self-evaluation , Critical realism
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/294956 , vital:57273 , DOI 10.21504/10962/294956
- Description: This study contributes to the literature on quality improvement in higher education by examining the structural, cultural and agential constraints and enablements on a quality process at a university in South Africa. It examined four cases and developed an understanding of the complex interaction of structure, culture and agency and the mechanisms that enable or constrain quality improvement in higher education. The study drew on the literature on higher education quality for the theoretical basis for what is known contributes to the way in which quality assurance and improvement is implemented and its impact on the higher education context. Critical Realism provided the ontological framework and conceptual tools to understand and explore the complex social world within which the quality process took place. The literature on the morphogenetic approach provided the analytical framework for the data analysis and findings. The data consisted of a set of documents from a quality process that took place over a five-year period. The data analysis revealed that different departmental contexts impact on how mechanisms are activated. Each school context shapes the way in which people engage with the review process and consequently, processes and procedures are mediated in each context. This research therefore adds to the understanding of the way in which quality processes take place at a micro-level within an institutional context and informs the approach to quality improvement more broadly, nationally and internationally. The research contributes to the knowledge that will inform planning, policies and practices in quality improvement processes in higher education and the findings identify a number of factors (mechanisms) that should inform the way in which a quality process is facilitated, will enable effective self-evaluation and review processes, and consequently are more likely to lead to quality improvement. , Thesis (PhD) -- Faculty of Education, Centre for Higher Education Research, Teaching and Learning, 2021
- Full Text:
- Date Issued: 2021-10-29
Curriculum adjustment and adaptive leadership in two service-learning courses at Rhodes University as a consequence of the COVID-19 pandemic
- Authors: Khuhlane, Heide Nozuko
- Date: 2021-10-29
- Subjects: COVID-19 (Disease) , Curriculum planning South Africa Makhanda , Rhodes University , Service learning South Africa Makhanda , Educational leadership South Africa Makhanda , Educational change South Africa Makhanda , Adaptive leadership
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191192 , vital:45069
- Description: The COVID-19 global pandemic altered many aspects of learning. Learning through service, a component of community engagement in higher education linking academic learning and the community was no exception. Informed by Experiential Learning Theory, this study investigated the curriculum adjustment of two service-learning courses at Rhodes University and the leadership development of those who lead the courses as a consequence of COVID-19. The study’s initial goal was to highlight the position of service-learning as a component of academic learning. With the onset of the COVID-19 pandemic the goal was extended to understanding the impact of the pandemic not only on service-learning, but on leadership as well. Furthermore, the study sought to determine the responsiveness of service-learning policies at Rhodes University at a time of crisis. The study was designed as an interpretivist case study with four participants and one secondary participant. The study employed document analysis, individual interviews and a focus group interview to collect data. Data analysis took the form of content analysis and coding, through the lens of Experiential Learning Theory and an alternative service-based model. The study findings revealed that as a result of the COVID-19 global pandemic both service-learning courses had to be adapted to ensure successful completion. The adaptations included attention to scaffolded learning, assessment and course outcomes; in one course the service engagement aspect with the community was lost entirely to ensure the saftey of students through adherence to COVID-19 safety regulations. The study also found that the participants developed adaptive leadership competencies and skills, technological and collaboration skills as well as a heightened regard for pastoral care and social justice. However, it was evident that the pandemic revealed gaps in the conceptual understanding of service-learning in the context of the two courses, a need for responsive policy, and practical strategies to implement those policies in smaller units in the institution. The study thus recommends an alternative service-based model approach to service-learning, increased policy responsiveness to issues posed by the ‘new normal’ to support adaptive leadership development, re-defining of the university-community partnership and the identification of opportunities for innovation and collaboration intra-departmentally through service-learning. , Thesis (MEd) -- Faculty of Education, Education, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Khuhlane, Heide Nozuko
- Date: 2021-10-29
- Subjects: COVID-19 (Disease) , Curriculum planning South Africa Makhanda , Rhodes University , Service learning South Africa Makhanda , Educational leadership South Africa Makhanda , Educational change South Africa Makhanda , Adaptive leadership
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191192 , vital:45069
- Description: The COVID-19 global pandemic altered many aspects of learning. Learning through service, a component of community engagement in higher education linking academic learning and the community was no exception. Informed by Experiential Learning Theory, this study investigated the curriculum adjustment of two service-learning courses at Rhodes University and the leadership development of those who lead the courses as a consequence of COVID-19. The study’s initial goal was to highlight the position of service-learning as a component of academic learning. With the onset of the COVID-19 pandemic the goal was extended to understanding the impact of the pandemic not only on service-learning, but on leadership as well. Furthermore, the study sought to determine the responsiveness of service-learning policies at Rhodes University at a time of crisis. The study was designed as an interpretivist case study with four participants and one secondary participant. The study employed document analysis, individual interviews and a focus group interview to collect data. Data analysis took the form of content analysis and coding, through the lens of Experiential Learning Theory and an alternative service-based model. The study findings revealed that as a result of the COVID-19 global pandemic both service-learning courses had to be adapted to ensure successful completion. The adaptations included attention to scaffolded learning, assessment and course outcomes; in one course the service engagement aspect with the community was lost entirely to ensure the saftey of students through adherence to COVID-19 safety regulations. The study also found that the participants developed adaptive leadership competencies and skills, technological and collaboration skills as well as a heightened regard for pastoral care and social justice. However, it was evident that the pandemic revealed gaps in the conceptual understanding of service-learning in the context of the two courses, a need for responsive policy, and practical strategies to implement those policies in smaller units in the institution. The study thus recommends an alternative service-based model approach to service-learning, increased policy responsiveness to issues posed by the ‘new normal’ to support adaptive leadership development, re-defining of the university-community partnership and the identification of opportunities for innovation and collaboration intra-departmentally through service-learning. , Thesis (MEd) -- Faculty of Education, Education, 2021
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- Date Issued: 2021-10-29