Cytotoxicity of lapachol, β-lapachone and related synthetic 1, 4-naphthoquinones against oesophageal cancer cells:
- Sunassee, Suthananda N, Veale, Clinton G L, Shunmoogam-Gounden, Nelusha, Osoniyi, Omalaja, Hendricks, Denver T, Caira, Mino R, de la Mare, Jo-Anne, Edkins, Adrienne L, Pinto, Antônio V, da Silva Junior, Eufrânio N, Davies-Coleman, Michael T
- Authors: Sunassee, Suthananda N , Veale, Clinton G L , Shunmoogam-Gounden, Nelusha , Osoniyi, Omalaja , Hendricks, Denver T , Caira, Mino R , de la Mare, Jo-Anne , Edkins, Adrienne L , Pinto, Antônio V , da Silva Junior, Eufrânio N , Davies-Coleman, Michael T
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165207 , vital:41218 , DOI: 10.1016/j.ejmech.2012.12.048
- Description: Naphthoquinones have been found to have a wide range of biological activities, including cytotoxicity to cancer cells. The secondary metabolites lapachol, α- and β-lapachone and a series of 25 related synthetic 1,4-naphthoquinones were screened against the oesophageal cancer cell line (WHCO1). Most of the compounds exhibited enhanced cytotoxicity (IC50 1.6–11.7 μM) compared to the current drug of choice cisplatin (IC50 = 16.5 μM).
- Full Text:
- Date Issued: 2013
- Authors: Sunassee, Suthananda N , Veale, Clinton G L , Shunmoogam-Gounden, Nelusha , Osoniyi, Omalaja , Hendricks, Denver T , Caira, Mino R , de la Mare, Jo-Anne , Edkins, Adrienne L , Pinto, Antônio V , da Silva Junior, Eufrânio N , Davies-Coleman, Michael T
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165207 , vital:41218 , DOI: 10.1016/j.ejmech.2012.12.048
- Description: Naphthoquinones have been found to have a wide range of biological activities, including cytotoxicity to cancer cells. The secondary metabolites lapachol, α- and β-lapachone and a series of 25 related synthetic 1,4-naphthoquinones were screened against the oesophageal cancer cell line (WHCO1). Most of the compounds exhibited enhanced cytotoxicity (IC50 1.6–11.7 μM) compared to the current drug of choice cisplatin (IC50 = 16.5 μM).
- Full Text:
- Date Issued: 2013
The implementation of a service-learning component in an organic chemistry laboratory course
- Glover, Sarah R, Sewry, Joyce D, Bromley, Candice L, Davies-Coleman, Michael T, Hlengwa, Amanda I
- Authors: Glover, Sarah R , Sewry, Joyce D , Bromley, Candice L , Davies-Coleman, Michael T , Hlengwa, Amanda I
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/70699 , vital:29690 , https://doi.org/10.1021/ed2008153
- Description: Education institutions globally are increasingly expected to explore avenues for the implementation of service-learning into their curricula. A second-year undergraduate organic chemistry laboratory experiment, in which the undergraduate students make azo dyes, can provide a vehicle for a service-learning module in which university undergraduate students then teach students from resource-limited secondary schools how to make azo dyes. Evidence is provided to show how the theory is reinforced for both sets of students through a shared practical experience. The practical application of chemistry is conveyed through the use of the synthetic azo dyes to dye tshirts. The results of this study show that the service-learning experience clearly assists undergraduate students to appreciate the role of chemists in the broader society while at the same time increasing awareness of the inequalities in school education systems.
- Full Text:
- Date Issued: 2013
- Authors: Glover, Sarah R , Sewry, Joyce D , Bromley, Candice L , Davies-Coleman, Michael T , Hlengwa, Amanda I
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/70699 , vital:29690 , https://doi.org/10.1021/ed2008153
- Description: Education institutions globally are increasingly expected to explore avenues for the implementation of service-learning into their curricula. A second-year undergraduate organic chemistry laboratory experiment, in which the undergraduate students make azo dyes, can provide a vehicle for a service-learning module in which university undergraduate students then teach students from resource-limited secondary schools how to make azo dyes. Evidence is provided to show how the theory is reinforced for both sets of students through a shared practical experience. The practical application of chemistry is conveyed through the use of the synthetic azo dyes to dye tshirts. The results of this study show that the service-learning experience clearly assists undergraduate students to appreciate the role of chemists in the broader society while at the same time increasing awareness of the inequalities in school education systems.
- Full Text:
- Date Issued: 2013
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