A comparative study of acute responses to running in elite black and white marathon athletes
- Authors: Bosch, Andrew Norman
- Date: 1985
- Subjects: Athletics , Sports -- Physiological aspects , Running races , Marathon running , Marathon running -- Physiological aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:5099 , http://hdl.handle.net/10962/d1001839 , Athletics , Sports -- Physiological aspects , Running races , Marathon running , Marathon running -- Physiological aspects
- Description: Experienced male marathon runners, 9 black and 10 white, with marathon times of 2 hours 45 minutes or faster, acted as subjects for the study, the purpose of which was to determine whether black runners are better suited to marathon running than whites. Body composition was determined by anthropometry. Maximal oxygen uptake (VO₂ max) and other physiological variables were measured during a continuous, speed-incremented treadmill protocol using a computer-aided data acquisition system. Subjects also ran a simulated marathon at 92.5% of the running speed at which the ventilatory threshold (VT) occurred. Physiological, gait and RPE variables were measured at 10 minute intervals during the marathon. Major findings are detailed below:- The VO₂, max averaged 60.4 ∓ 6.5 and 63.2 ∓ 2.9 mI. kg⁻¹.min⁻¹ in the black and white runners respectively and was highly correlated with best marathon race time (r = 0.86 and 0.85 respectively) and VT (r = 0.84 and 0.60 respectively) (p < 0.05). No significant differences existed between the groups in submaximal oxygen uptake (VO₂,) or % VO₂ max utilised at 16 km.hr⁻¹, but the estimated % VO₂ max utilised during a marathon race was higher in the black (89.0 ∓ 5.5%) than the white runners (81. 5 ∓ 3.1%) {p .( 0.05). The % VO₂ max utilised at 16 km.hr⁻¹ (84.8 ∓ 9.1 and 78.6 ∓ 5.8% in the black and white runners respectively) was significantly correlated with the % VO₂, max utilised while racing in the white (81.5 ∓ 3.1%) (r = 0.70) (p < 0.05), but not the black runners (89.0 ∓ 5.5%). The VT occurred at 82.7 ∓ 7.7 and 75.6 :∓ 6.2% VO₂; max in the black and white groups respectively (p < 0.05). Post-marathon blood lactic acid levels were lower in the black (1.30 ∓ 0.26 mmo1.l⁻¹) than the white runners (1.59 ∓ 0.20 mmol.l⁻¹). The respiratory exchange ratio (R) was higher in the blacks than whites when running at 16 km.hr ⁻¹ (1.03 ∓ 0.07 and 0.98 ∓ 0.03 respectively) and during the marathon (p < 0.05). There was no significant difference in pulmonary minute ventilation (Vı) between the groups, but breathing frequency (f) was higher in the black (59 ∓ 12 breaths.min⁻¹) than the white runners (45 ∓ 8 breaths. min⁻¹ ) and tidal volume (V⊤) lower in the black ( 1.33 ∓ 0.16 l.breath⁻¹) than the white runners (1.75 ∓ 0.36 I.breath⁻¹) during submaximal running at 16 km. hr⁻¹ (p < 0.05). The same trend was observed during the marathon run. During the time-course of the marathon f increased and V⊤ decreased In both groups (p < 0.05). Stroke volume decreased and heart rate increased In both groups during the time-course of the marathon (p< 0.05). Cardiac output was therefore maintained. Thermal responses were similar in the two groups. A significant increase in rectal temperature coincided with a decrease in skin temperature and may have been related to an increase in f (r = 0.86 and 0.67 in the blacks and whites respectively), H/R (r = 0.70 and 0.67 respectively) and "local" (leg) RPE (r = 0.84 and 0.82 respectively). It was concluded that black runners were able to run marathon races at a higher % VO₂ more than whites due to the blacks having lower blood lactic acid levels when running at a similar % VO₂ max. Given similar maximal oxygen uptakes, this would enable blacks to run faster. Cardiopulmonary adjustments occur during the time-course of a marathon which maintains Q and Vı
- Full Text:
- Authors: Bosch, Andrew Norman
- Date: 1985
- Subjects: Athletics , Sports -- Physiological aspects , Running races , Marathon running , Marathon running -- Physiological aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:5099 , http://hdl.handle.net/10962/d1001839 , Athletics , Sports -- Physiological aspects , Running races , Marathon running , Marathon running -- Physiological aspects
- Description: Experienced male marathon runners, 9 black and 10 white, with marathon times of 2 hours 45 minutes or faster, acted as subjects for the study, the purpose of which was to determine whether black runners are better suited to marathon running than whites. Body composition was determined by anthropometry. Maximal oxygen uptake (VO₂ max) and other physiological variables were measured during a continuous, speed-incremented treadmill protocol using a computer-aided data acquisition system. Subjects also ran a simulated marathon at 92.5% of the running speed at which the ventilatory threshold (VT) occurred. Physiological, gait and RPE variables were measured at 10 minute intervals during the marathon. Major findings are detailed below:- The VO₂, max averaged 60.4 ∓ 6.5 and 63.2 ∓ 2.9 mI. kg⁻¹.min⁻¹ in the black and white runners respectively and was highly correlated with best marathon race time (r = 0.86 and 0.85 respectively) and VT (r = 0.84 and 0.60 respectively) (p < 0.05). No significant differences existed between the groups in submaximal oxygen uptake (VO₂,) or % VO₂ max utilised at 16 km.hr⁻¹, but the estimated % VO₂ max utilised during a marathon race was higher in the black (89.0 ∓ 5.5%) than the white runners (81. 5 ∓ 3.1%) {p .( 0.05). The % VO₂ max utilised at 16 km.hr⁻¹ (84.8 ∓ 9.1 and 78.6 ∓ 5.8% in the black and white runners respectively) was significantly correlated with the % VO₂, max utilised while racing in the white (81.5 ∓ 3.1%) (r = 0.70) (p < 0.05), but not the black runners (89.0 ∓ 5.5%). The VT occurred at 82.7 ∓ 7.7 and 75.6 :∓ 6.2% VO₂; max in the black and white groups respectively (p < 0.05). Post-marathon blood lactic acid levels were lower in the black (1.30 ∓ 0.26 mmo1.l⁻¹) than the white runners (1.59 ∓ 0.20 mmol.l⁻¹). The respiratory exchange ratio (R) was higher in the blacks than whites when running at 16 km.hr ⁻¹ (1.03 ∓ 0.07 and 0.98 ∓ 0.03 respectively) and during the marathon (p < 0.05). There was no significant difference in pulmonary minute ventilation (Vı) between the groups, but breathing frequency (f) was higher in the black (59 ∓ 12 breaths.min⁻¹) than the white runners (45 ∓ 8 breaths. min⁻¹ ) and tidal volume (V⊤) lower in the black ( 1.33 ∓ 0.16 l.breath⁻¹) than the white runners (1.75 ∓ 0.36 I.breath⁻¹) during submaximal running at 16 km. hr⁻¹ (p < 0.05). The same trend was observed during the marathon run. During the time-course of the marathon f increased and V⊤ decreased In both groups (p < 0.05). Stroke volume decreased and heart rate increased In both groups during the time-course of the marathon (p< 0.05). Cardiac output was therefore maintained. Thermal responses were similar in the two groups. A significant increase in rectal temperature coincided with a decrease in skin temperature and may have been related to an increase in f (r = 0.86 and 0.67 in the blacks and whites respectively), H/R (r = 0.70 and 0.67 respectively) and "local" (leg) RPE (r = 0.84 and 0.82 respectively). It was concluded that black runners were able to run marathon races at a higher % VO₂ more than whites due to the blacks having lower blood lactic acid levels when running at a similar % VO₂ max. Given similar maximal oxygen uptakes, this would enable blacks to run faster. Cardiopulmonary adjustments occur during the time-course of a marathon which maintains Q and Vı
- Full Text:
A contribution to the oceanology of the Prince Edward Islands
- Authors: Parker, Llewellyn Derek
- Date: 1985
- Subjects: Oceanography -- Prince Edward Islands
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5605 , http://hdl.handle.net/10962/d1002055
- Description: While the terrestrial ecosystem of the Prince Edward Island Group has been subject to intensive research, the marine ecosystem has to a large extent been neglected. This together with the possible existence of an "island effect" at these islands, as was first proposed after the visit to these islands of the French vessel Marion Dufresne, led to the initiation of a programme to determine the distribution of standing stocks and the productivity of phytoplankton and zooplankton in the neritic seas of these islands. To do this and before a detailed biological survey could be attempted, it was first necessary to define the physical and chemical properties of the circuminsular waters. This dissertation discusses the results of several surveys to these islands in the light of a possible "island effect" and comments upon processes likely to influence such an effect
- Full Text:
- Authors: Parker, Llewellyn Derek
- Date: 1985
- Subjects: Oceanography -- Prince Edward Islands
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5605 , http://hdl.handle.net/10962/d1002055
- Description: While the terrestrial ecosystem of the Prince Edward Island Group has been subject to intensive research, the marine ecosystem has to a large extent been neglected. This together with the possible existence of an "island effect" at these islands, as was first proposed after the visit to these islands of the French vessel Marion Dufresne, led to the initiation of a programme to determine the distribution of standing stocks and the productivity of phytoplankton and zooplankton in the neritic seas of these islands. To do this and before a detailed biological survey could be attempted, it was first necessary to define the physical and chemical properties of the circuminsular waters. This dissertation discusses the results of several surveys to these islands in the light of a possible "island effect" and comments upon processes likely to influence such an effect
- Full Text:
A geographical analysis of farming in East Griqualand
- Authors: Leslie, Kathryn Ann
- Date: 1985
- Subjects: Agriculture -- Griqualand East (South Africa) , Rural development -- Griqualand East (South Africa) , Agricultural deography -- Griqualand East (South Africa) , Geography -- Methodology , Infrastructure (Economics) -- Griqualand East (South Africa)
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:4860 , http://hdl.handle.net/10962/d1005857 , Agriculture -- Griqualand East (South Africa) , Rural development -- Griqualand East (South Africa) , Agricultural deography -- Griqualand East (South Africa) , Geography -- Methodology , Infrastructure (Economics) -- Griqualand East (South Africa)
- Description: From Preface: The study focusses on spatial aspects of farming and particularly how di stance from marketing centres influences farming activity. However, not all aspects of farming activity could be given close attention due to the limited time and funds available and it was decided to isolate two aspects of farming activity for detailed study, namely, farm size and intensity. Other variables, such as land-use, are looked at in relation to the two main variables. Although East Griqualand is the general area selected for study, for practical purposes it was decided to select areas within East Griqualand for an in-depth study. As the study focusses on the influence of distance from marketing centres on farming activity, it was decided to select marketing centres in East Griqualand around which farming takes place. There are six of these centres in East Griqualand, that is, Kokstad, Matatiele, Cedarville, Franklin, Swartberg and New Amalfi. Two marketing centres, Cedarville and Swartberg, were selected and the farms served by these centres became the two sub-areas in which the research was conducted. The selection of the marketing centres and the justification for this selection is discussed in Chapter Four. A problem arose when calculating the distance from the farming unit to the marketing centre where a single set of books is kept even though the farming unit does not consist of one contiguous area. It was, however, found that all farmers conduct farming operations from a central farm, usually that on which they reside and on which farming implements and other farming requirements are stored. The distance was therefore calculated from the farm gate of the farm from which farming operations are controlled. The general study area is show in Figure 6. However, it was difficult to delimit the exact study area on the map as many of the farm boundaries were imperfectly known by farmers and were considered confidential information by local agricultural officials. The two sub-areas consist of the areas surrounding the marketing centres of Cedarville and Swartberg respectively. As a study of this nature has not previously been conducted in East Griqualand, it was decided that the study should constitute a pilot survey. As such, the study is a preliminary survey aimed at identifying general trends of the relationship between distance to marketing centres, farm size and intensity of fanning in the selected areas. The study could therefore be used to provide pointers for further research and act as a basis for a more comprehensive study of the same nature in East Griqualand.
- Full Text:
- Authors: Leslie, Kathryn Ann
- Date: 1985
- Subjects: Agriculture -- Griqualand East (South Africa) , Rural development -- Griqualand East (South Africa) , Agricultural deography -- Griqualand East (South Africa) , Geography -- Methodology , Infrastructure (Economics) -- Griqualand East (South Africa)
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:4860 , http://hdl.handle.net/10962/d1005857 , Agriculture -- Griqualand East (South Africa) , Rural development -- Griqualand East (South Africa) , Agricultural deography -- Griqualand East (South Africa) , Geography -- Methodology , Infrastructure (Economics) -- Griqualand East (South Africa)
- Description: From Preface: The study focusses on spatial aspects of farming and particularly how di stance from marketing centres influences farming activity. However, not all aspects of farming activity could be given close attention due to the limited time and funds available and it was decided to isolate two aspects of farming activity for detailed study, namely, farm size and intensity. Other variables, such as land-use, are looked at in relation to the two main variables. Although East Griqualand is the general area selected for study, for practical purposes it was decided to select areas within East Griqualand for an in-depth study. As the study focusses on the influence of distance from marketing centres on farming activity, it was decided to select marketing centres in East Griqualand around which farming takes place. There are six of these centres in East Griqualand, that is, Kokstad, Matatiele, Cedarville, Franklin, Swartberg and New Amalfi. Two marketing centres, Cedarville and Swartberg, were selected and the farms served by these centres became the two sub-areas in which the research was conducted. The selection of the marketing centres and the justification for this selection is discussed in Chapter Four. A problem arose when calculating the distance from the farming unit to the marketing centre where a single set of books is kept even though the farming unit does not consist of one contiguous area. It was, however, found that all farmers conduct farming operations from a central farm, usually that on which they reside and on which farming implements and other farming requirements are stored. The distance was therefore calculated from the farm gate of the farm from which farming operations are controlled. The general study area is show in Figure 6. However, it was difficult to delimit the exact study area on the map as many of the farm boundaries were imperfectly known by farmers and were considered confidential information by local agricultural officials. The two sub-areas consist of the areas surrounding the marketing centres of Cedarville and Swartberg respectively. As a study of this nature has not previously been conducted in East Griqualand, it was decided that the study should constitute a pilot survey. As such, the study is a preliminary survey aimed at identifying general trends of the relationship between distance to marketing centres, farm size and intensity of fanning in the selected areas. The study could therefore be used to provide pointers for further research and act as a basis for a more comprehensive study of the same nature in East Griqualand.
- Full Text:
A geographical analysis of nutrition in the Eastern Cape and Ciskei
- Authors: Fincham, Robert John
- Date: 1985
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4812 , http://hdl.handle.net/10962/d1004905
- Description: From preface: The primary aim of the thesis is to make an anthropometric assessment of levels of nutrition of black pre-school children in selected communities of the Eastern Cape and Ciskei. The communities are those of black labourers and their families on white-owned commercial farms in the Dias Divisional Council area of the Eastern Cape; a rural community of an area of Ciskei known as the Amatola Basin; and Tsweletsl'lele, a 'closer settlement' or resettlement area in Ciskei. A pilot survey of school entrants in the Albany magisterial district also sheds light on the nutrition of children in the small towns, such as Grahamstown, of the Eastern Cape. Through an analysis of nutritional conditions in these disparate communities, it should be possible to begin to establish the geographical variation of nutrition in the region. Black communities in the metropolitan area of Port Elizabeth are not considered in the thesis, but on-going surveillance in the city, by the author, will elucidate nutritional conditions there. In achieving the primary aim of the thesis, attention will be focussed on inter-community rather than intra-community variation in nutrition. Nutrition may vary within communities (intra-community variation), for example, within different parts of the Dias Divisional Council area. While such variation is 1 ikely to be minimal, as will be discussed in the presentation of results in chapter 6, section A(l), it is in itself important, and present research endeavours within the surveillance programme are being geared to explore this dimension of nutritional variation more fully. Inter-community variation in nutrition provides, however, a more than sufficient focus for the thesis. A secondary aim of the thesis is to explore the relationship between nutritional status and socio-economic conditions prevailing in the surveyed communities. The secondary aim makes it possible to obtain a better understanding of the processes whi ch infl uence the geographical pattern of nutrition. A consideration of socio-economic conditions, both within the communities and within the Eastern Cape and Ciskei as a whole, also provides a context in which the nutrition results can be assessed. The third aim of the thesis is to assess possible applications of the survey results to policy formulation, thereby providing an applied dimension to the work.
- Full Text:
- Authors: Fincham, Robert John
- Date: 1985
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4812 , http://hdl.handle.net/10962/d1004905
- Description: From preface: The primary aim of the thesis is to make an anthropometric assessment of levels of nutrition of black pre-school children in selected communities of the Eastern Cape and Ciskei. The communities are those of black labourers and their families on white-owned commercial farms in the Dias Divisional Council area of the Eastern Cape; a rural community of an area of Ciskei known as the Amatola Basin; and Tsweletsl'lele, a 'closer settlement' or resettlement area in Ciskei. A pilot survey of school entrants in the Albany magisterial district also sheds light on the nutrition of children in the small towns, such as Grahamstown, of the Eastern Cape. Through an analysis of nutritional conditions in these disparate communities, it should be possible to begin to establish the geographical variation of nutrition in the region. Black communities in the metropolitan area of Port Elizabeth are not considered in the thesis, but on-going surveillance in the city, by the author, will elucidate nutritional conditions there. In achieving the primary aim of the thesis, attention will be focussed on inter-community rather than intra-community variation in nutrition. Nutrition may vary within communities (intra-community variation), for example, within different parts of the Dias Divisional Council area. While such variation is 1 ikely to be minimal, as will be discussed in the presentation of results in chapter 6, section A(l), it is in itself important, and present research endeavours within the surveillance programme are being geared to explore this dimension of nutritional variation more fully. Inter-community variation in nutrition provides, however, a more than sufficient focus for the thesis. A secondary aim of the thesis is to explore the relationship between nutritional status and socio-economic conditions prevailing in the surveyed communities. The secondary aim makes it possible to obtain a better understanding of the processes whi ch infl uence the geographical pattern of nutrition. A consideration of socio-economic conditions, both within the communities and within the Eastern Cape and Ciskei as a whole, also provides a context in which the nutrition results can be assessed. The third aim of the thesis is to assess possible applications of the survey results to policy formulation, thereby providing an applied dimension to the work.
- Full Text:
A historico-theological study of Pentecostalism as a phenomenon within a South African community
- Authors: Pillay, Gerald J
- Date: 1985
- Subjects: Pentecostalism -- South Africa Pentecostal churches -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1222 , http://hdl.handle.net/10962/d1001552
- Description: Preface: An attempt is made in this thesis to document the history of Pentecostalism among Indians in South Africa and to study and evaluate its religious character and main theological tenets. Obviously the peculiar socio-political situation of the Indians in South Africa has influenced the character of Indian Pentecostalism, which has in turn been able to address itself to the critical, cultural and religious disjunctions within this community. Hence an investigation of the dynamic tensions that obtain between crises in the Indian community and Pentecostalism will not only clarify the course of its history but will also explain its theological emphases. However, several studies on Pentecostalism in other communities have concentrated on the sociological dimension almost exclusively and many have even concluded that Pentecostalism is the spontaneous result of psychosocial; economic or cultural upheavals . This kind of reductionism has been largely the result of the uncritical use of 'functional-type' theories postulated by sociologists of religion. Indian Pentecostalism, while it has to be examined within the complex context of the South African community, cannot as we shall show, be adequately explained by any of the prevailing 'functional-type' theories because these theories reduce religion to a sociological function. Since the functional theory has the effect of limiting the perspective on religion to such an extent that the basis of religion, that is, the relation between the individual and faith, is either belittled or ignored, it has been jettisoned in this thesis for an approach free of any deliberately formulated 'theoretical framework'. However, it is necessary to critically examine some of the more popular 'functional-type' theories and the way they have been applied to the study of the Pentecostal movement here and elsewhere, so that by exposing the shortcomings of their application and the contradictions inherent in their assumptions, the approach adopted in this thesis could be clarified.
- Full Text:
- Authors: Pillay, Gerald J
- Date: 1985
- Subjects: Pentecostalism -- South Africa Pentecostal churches -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1222 , http://hdl.handle.net/10962/d1001552
- Description: Preface: An attempt is made in this thesis to document the history of Pentecostalism among Indians in South Africa and to study and evaluate its religious character and main theological tenets. Obviously the peculiar socio-political situation of the Indians in South Africa has influenced the character of Indian Pentecostalism, which has in turn been able to address itself to the critical, cultural and religious disjunctions within this community. Hence an investigation of the dynamic tensions that obtain between crises in the Indian community and Pentecostalism will not only clarify the course of its history but will also explain its theological emphases. However, several studies on Pentecostalism in other communities have concentrated on the sociological dimension almost exclusively and many have even concluded that Pentecostalism is the spontaneous result of psychosocial; economic or cultural upheavals . This kind of reductionism has been largely the result of the uncritical use of 'functional-type' theories postulated by sociologists of religion. Indian Pentecostalism, while it has to be examined within the complex context of the South African community, cannot as we shall show, be adequately explained by any of the prevailing 'functional-type' theories because these theories reduce religion to a sociological function. Since the functional theory has the effect of limiting the perspective on religion to such an extent that the basis of religion, that is, the relation between the individual and faith, is either belittled or ignored, it has been jettisoned in this thesis for an approach free of any deliberately formulated 'theoretical framework'. However, it is necessary to critically examine some of the more popular 'functional-type' theories and the way they have been applied to the study of the Pentecostal movement here and elsewhere, so that by exposing the shortcomings of their application and the contradictions inherent in their assumptions, the approach adopted in this thesis could be clarified.
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A hydrogeological assessment of the Uitenhage-Coega artesian system
- Authors: Venables, Anthony John
- Date: 1985
- Subjects: Hydrogeology -- South Africa Aquifers -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4808 , http://hdl.handle.net/10962/d1003815
- Description: The Uitenhage artesian aquifer north-west of Port Elizabeth in South Africa, is one of the few artesian groundwater systems in Southern Africa. The Uitenhage - Coega, and Kruis River areas, are the most important portions of the Uitenhage Artesian System in terms of water abstraction and water use. This study concentrates on the Uitenhage - Coega area and in particular, on the Coega Ridge where the Table Mountain Sandstone (TNS) aquifer occurs at relatively shallow depths. The investigation is aimed at assessing the geological, hydrogeological and hydrochemical characteristics of the HIS and any other aquifers present, with the object of providing quantitative data for use in future decisions on the water resource management of the area. In order to achieve these objectives, field work, involving a hydrocensus, geological mapping, geophysical exploration, drilling, aquifer testing and hydrochemical sampling was carried out. Analysis of these data provided information on the extent of the aquifers, their hydrogeological characteristics and the chemical nature of the various groundwater types.
- Full Text:
- Authors: Venables, Anthony John
- Date: 1985
- Subjects: Hydrogeology -- South Africa Aquifers -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4808 , http://hdl.handle.net/10962/d1003815
- Description: The Uitenhage artesian aquifer north-west of Port Elizabeth in South Africa, is one of the few artesian groundwater systems in Southern Africa. The Uitenhage - Coega, and Kruis River areas, are the most important portions of the Uitenhage Artesian System in terms of water abstraction and water use. This study concentrates on the Uitenhage - Coega area and in particular, on the Coega Ridge where the Table Mountain Sandstone (TNS) aquifer occurs at relatively shallow depths. The investigation is aimed at assessing the geological, hydrogeological and hydrochemical characteristics of the HIS and any other aquifers present, with the object of providing quantitative data for use in future decisions on the water resource management of the area. In order to achieve these objectives, field work, involving a hydrocensus, geological mapping, geophysical exploration, drilling, aquifer testing and hydrochemical sampling was carried out. Analysis of these data provided information on the extent of the aquifers, their hydrogeological characteristics and the chemical nature of the various groundwater types.
- Full Text:
A novel adjuvant : polymerised serum albumin beads
- Authors: Dewar, John Barr
- Date: 1985
- Subjects: Antigens , Serum albumin
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4104 , http://hdl.handle.net/10962/d1011146 , Antigens , Serum albumin
- Description: Lee, T. et al (1981) proposed the encapsulation of hormones such as progesterone into serum albumin beads, such that their in vivo proteolysis would allow a gradual release of hormone at low levels, for extended hormone action. It was proposed, in the Department of Microbiology, Rhodes University, to replace the hormone component of the above bead formulation, with virus as antigen, in the development of a vaccine. Beads optimally crosslinked at 1% final glutaraldehyde concentration, containing Nodamura virus, were shown to promote an adjuvant effect in vivo, analogous to the release of antigen from Freund's Complete Adjuvant (FCA), so that extended immunostimulation resulted. It was shown that soluble antigen promoted a short-lived primary immune response, peaking around day 25 following inoculation. Antigen presented in beads, on the other hand, initially elicited a low humoral response, but this response gradually increased up to a peak around day 110 post inoculation, before decreasing. No apparent adverse side-effects were noted following inoculation of antigen-containing serum albumin beads, compared to necrosis following antigen in FCA inoculation, supporting the proposal of using albumin homotypic for the test inoculee animal, so that the beads would themselves be non-immunogenic and would merely act as a vehicle in the vaccine formulation. The indirect enzyme-linked immunosorbent assay (ELISA) was used to monitor the humoral response to antigen following inoculation. Results showed that covalent crosslinking of albumin in the formation of the beads did not promote immunogenicity on the part of the chemically altered albumin. The ELISA test was used to indicate the kinetics of the IgG response to Nodamura virus when presented in formulations such as: Freely soluble virus or its subunit; soluble intact virus inactivated by treatment with glutaraldehyde; intact virus entrapped in serum albumin beads cross; linked at different percentage final glutaraldehyde concentrations and also virus subunit prepared in albumin beads. The presence of virus-neutral ising antibodies was noted in serum obtained from rabbits inoculated with virus entrapped in albumin beads. Virus infectivity, titrated in mice, showed protection against virus challenge after incubation of virus with serum obtained above.
- Full Text:
- Authors: Dewar, John Barr
- Date: 1985
- Subjects: Antigens , Serum albumin
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4104 , http://hdl.handle.net/10962/d1011146 , Antigens , Serum albumin
- Description: Lee, T. et al (1981) proposed the encapsulation of hormones such as progesterone into serum albumin beads, such that their in vivo proteolysis would allow a gradual release of hormone at low levels, for extended hormone action. It was proposed, in the Department of Microbiology, Rhodes University, to replace the hormone component of the above bead formulation, with virus as antigen, in the development of a vaccine. Beads optimally crosslinked at 1% final glutaraldehyde concentration, containing Nodamura virus, were shown to promote an adjuvant effect in vivo, analogous to the release of antigen from Freund's Complete Adjuvant (FCA), so that extended immunostimulation resulted. It was shown that soluble antigen promoted a short-lived primary immune response, peaking around day 25 following inoculation. Antigen presented in beads, on the other hand, initially elicited a low humoral response, but this response gradually increased up to a peak around day 110 post inoculation, before decreasing. No apparent adverse side-effects were noted following inoculation of antigen-containing serum albumin beads, compared to necrosis following antigen in FCA inoculation, supporting the proposal of using albumin homotypic for the test inoculee animal, so that the beads would themselves be non-immunogenic and would merely act as a vehicle in the vaccine formulation. The indirect enzyme-linked immunosorbent assay (ELISA) was used to monitor the humoral response to antigen following inoculation. Results showed that covalent crosslinking of albumin in the formation of the beads did not promote immunogenicity on the part of the chemically altered albumin. The ELISA test was used to indicate the kinetics of the IgG response to Nodamura virus when presented in formulations such as: Freely soluble virus or its subunit; soluble intact virus inactivated by treatment with glutaraldehyde; intact virus entrapped in serum albumin beads cross; linked at different percentage final glutaraldehyde concentrations and also virus subunit prepared in albumin beads. The presence of virus-neutral ising antibodies was noted in serum obtained from rabbits inoculated with virus entrapped in albumin beads. Virus infectivity, titrated in mice, showed protection against virus challenge after incubation of virus with serum obtained above.
- Full Text:
A stability-indicating HPLC assay with on-line clean-up for betamethasone 17-valerate in topical dosage forms
- Smith, Eric W, Haigh, John M, Kanfer, Isadore
- Authors: Smith, Eric W , Haigh, John M , Kanfer, Isadore
- Date: 1985
- Language: English
- Type: Article
- Identifier: vital:6421 , http://hdl.handle.net/10962/d1006556
- Description: A stability-indicating high-performance liquid chromatographic method with on-line clean-up has been developed for the analysis of betamethasone 17-valerate in topical dosage forms. A short pre-column containing 10 μm octadecylsilane mounted into the sample loop position of an injection valve was used as the primary clean-up step. The utilization of a diode-array UV detector allowed the quantitative analysis of betamethasone 17-valerate together with its degradation product, betamethasone 21-valerate, as well as the qualitative analysis of these compounds, relevant internal standards and the preservatives chlorocresol and methyl hydroxybenzoate contained in the cream and lotion formulations, respectively. Typically, cream and lotion dosage forms were dissolved in acetonitrile and ointments in tetrahydrofuran, internal standards added and aliquots injected onto the analytical system. Dosage form excipients were retained on the loop column and back-flushed to waste with the aid of a second solvent pump while components of interest were allowed to transfer to the analytical column for quantitative analysis. The method is accurate, precise and stability indicating and permits the rapid on-line analysis of betamethasone 17-valerate from complex topical formulation matrices without prior extractions.
- Full Text:
- Authors: Smith, Eric W , Haigh, John M , Kanfer, Isadore
- Date: 1985
- Language: English
- Type: Article
- Identifier: vital:6421 , http://hdl.handle.net/10962/d1006556
- Description: A stability-indicating high-performance liquid chromatographic method with on-line clean-up has been developed for the analysis of betamethasone 17-valerate in topical dosage forms. A short pre-column containing 10 μm octadecylsilane mounted into the sample loop position of an injection valve was used as the primary clean-up step. The utilization of a diode-array UV detector allowed the quantitative analysis of betamethasone 17-valerate together with its degradation product, betamethasone 21-valerate, as well as the qualitative analysis of these compounds, relevant internal standards and the preservatives chlorocresol and methyl hydroxybenzoate contained in the cream and lotion formulations, respectively. Typically, cream and lotion dosage forms were dissolved in acetonitrile and ointments in tetrahydrofuran, internal standards added and aliquots injected onto the analytical system. Dosage form excipients were retained on the loop column and back-flushed to waste with the aid of a second solvent pump while components of interest were allowed to transfer to the analytical column for quantitative analysis. The method is accurate, precise and stability indicating and permits the rapid on-line analysis of betamethasone 17-valerate from complex topical formulation matrices without prior extractions.
- Full Text:
A study of germination and flowering in Cichorium intybus. L
- Authors: Minnaar, Hugo Roelof
- Date: 1985
- Subjects: Chicory -- South Africa Germination Seeds -- Development Plants -- Flowering of
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4178 , http://hdl.handle.net/10962/d1002027
- Description: Chicory (Cichorium intybus L) is a deep rooted biennial (or weakly perennial) composite that is grown as an annual in South Africa for its parsnip-like root. In its wild state the plant is a perennial with thin fibrous roots, but, through selection and propagation, cultivars with large, fleshy roots have been developed. From a purely horticultural standpoint, chicory is of interest as a pot-herb, a salad plant and as a root (Bailey, 1942) . As a root, the chicory plant represents an important article of commerce. In South Africa, the plants are grown virtually exclusively for their roots which, after drying, roasting and grinding, are used as an additive to, or substitute for, coffee (Introduction p. 11)
- Full Text:
- Authors: Minnaar, Hugo Roelof
- Date: 1985
- Subjects: Chicory -- South Africa Germination Seeds -- Development Plants -- Flowering of
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4178 , http://hdl.handle.net/10962/d1002027
- Description: Chicory (Cichorium intybus L) is a deep rooted biennial (or weakly perennial) composite that is grown as an annual in South Africa for its parsnip-like root. In its wild state the plant is a perennial with thin fibrous roots, but, through selection and propagation, cultivars with large, fleshy roots have been developed. From a purely horticultural standpoint, chicory is of interest as a pot-herb, a salad plant and as a root (Bailey, 1942) . As a root, the chicory plant represents an important article of commerce. In South Africa, the plants are grown virtually exclusively for their roots which, after drying, roasting and grinding, are used as an additive to, or substitute for, coffee (Introduction p. 11)
- Full Text:
A study of the molecular variation between orbivirus proteins
- Authors: Whistler, Toni
- Date: 1985 , 2013-03-13
- Subjects: Proteins -- Analysis , Polypeptides , Bluetongue virus , Orbivirus infections
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3892 , http://hdl.handle.net/10962/d1003290 , Proteins -- Analysis , Polypeptides , Bluetongue virus , Orbivirus infections
- Description: The aim of this study was to initiate a structural analysis of the capsid polypeptides from several serotypes of bluetongue virus in order to provide insight into the relatedness and possible origins of the different serotypes. Tryptic peptide mapping of ¹²⁵I-labelled group antigen by ion exchange chromatography was used to assess the structural relatedness of seven BTV serotypes from Southern Africa, North America and Australia. Each serotype had several tyrosine containing tryptic peptides which were unique, but approximately 35% of the peptides analyzed were found to be highly conserved between all 7 serotypes. BTV-20 appeared to be closely related to BTV-B and these two serotypes with BTV-4 and BTV-17 appeared to form a closely knit central cluster. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Authors: Whistler, Toni
- Date: 1985 , 2013-03-13
- Subjects: Proteins -- Analysis , Polypeptides , Bluetongue virus , Orbivirus infections
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3892 , http://hdl.handle.net/10962/d1003290 , Proteins -- Analysis , Polypeptides , Bluetongue virus , Orbivirus infections
- Description: The aim of this study was to initiate a structural analysis of the capsid polypeptides from several serotypes of bluetongue virus in order to provide insight into the relatedness and possible origins of the different serotypes. Tryptic peptide mapping of ¹²⁵I-labelled group antigen by ion exchange chromatography was used to assess the structural relatedness of seven BTV serotypes from Southern Africa, North America and Australia. Each serotype had several tyrosine containing tryptic peptides which were unique, but approximately 35% of the peptides analyzed were found to be highly conserved between all 7 serotypes. BTV-20 appeared to be closely related to BTV-B and these two serotypes with BTV-4 and BTV-17 appeared to form a closely knit central cluster. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
A study of the numinous presence in Tennyson's poetry
- Louw, Denise Elizabeth Laurence
- Authors: Louw, Denise Elizabeth Laurence
- Date: 1985
- Subjects: Tennyson, Alfred Tennyson, Baron, 1809-1892 -- Criticism and interpretation , English poetry -- 19th century -- History and criticism
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2268 , http://hdl.handle.net/10962/d1005891 , Tennyson, Alfred Tennyson, Baron, 1809-1892 -- Criticism and interpretation , English poetry -- 19th century -- History and criticism
- Description: From Preface: A reader looking to this study for a charting of the diverse religious views held by Tennyson at different periods in his life may be disappointed. My primary concern has been not with religious forms, but with the numinous impulse. However, though I approached the topic with a completely open mind, I find my own Christian convictions have been strengthened through the study of Tennyson's poetry. As the title indicates, I have not attempted to deal with the plays. To explore both the poetry and the plays in a study of this length would have been impossible. I have perhaps been somewhat unorthodox in attempting to combine several disciplines, especially since I cannot claim to be a specialist in the areas concerned. However, I felt it necessary to approach the subject from a number of points of view, and to see to what extent the results could be said to converge on some sort of central "truth". When I have despaired of being able to do justice to a particular aspect within the imposed limits, I have sometimes found comfort in the words of Alan Sinfield (The Language of Tennyson's "In Memoriam", p.211): "We can only endeavour continually to approach a little closer to the central mystery; the ma j or advances will be infrequent, but most attempts should furnish one or two hints which others will develop. "
- Full Text:
- Authors: Louw, Denise Elizabeth Laurence
- Date: 1985
- Subjects: Tennyson, Alfred Tennyson, Baron, 1809-1892 -- Criticism and interpretation , English poetry -- 19th century -- History and criticism
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2268 , http://hdl.handle.net/10962/d1005891 , Tennyson, Alfred Tennyson, Baron, 1809-1892 -- Criticism and interpretation , English poetry -- 19th century -- History and criticism
- Description: From Preface: A reader looking to this study for a charting of the diverse religious views held by Tennyson at different periods in his life may be disappointed. My primary concern has been not with religious forms, but with the numinous impulse. However, though I approached the topic with a completely open mind, I find my own Christian convictions have been strengthened through the study of Tennyson's poetry. As the title indicates, I have not attempted to deal with the plays. To explore both the poetry and the plays in a study of this length would have been impossible. I have perhaps been somewhat unorthodox in attempting to combine several disciplines, especially since I cannot claim to be a specialist in the areas concerned. However, I felt it necessary to approach the subject from a number of points of view, and to see to what extent the results could be said to converge on some sort of central "truth". When I have despaired of being able to do justice to a particular aspect within the imposed limits, I have sometimes found comfort in the words of Alan Sinfield (The Language of Tennyson's "In Memoriam", p.211): "We can only endeavour continually to approach a little closer to the central mystery; the ma j or advances will be infrequent, but most attempts should furnish one or two hints which others will develop. "
- Full Text:
Address to new students, 11 February 1985
- Authors: Henderson, Derek Scott
- Date: 1985
- Language: English
- Type: text
- Identifier: vital:7485 , http://hdl.handle.net/10962/d1018362
- Full Text:
- Authors: Henderson, Derek Scott
- Date: 1985
- Language: English
- Type: text
- Identifier: vital:7485 , http://hdl.handle.net/10962/d1018362
- Full Text:
Address to USSALEP Young Academics Alumni Conference 1985
- Authors: Henderson, Derek Scott
- Date: 1985
- Language: English
- Type: Text
- Identifier: vital:7516 , http://hdl.handle.net/10962/d1018393
- Full Text:
- Authors: Henderson, Derek Scott
- Date: 1985
- Language: English
- Type: Text
- Identifier: vital:7516 , http://hdl.handle.net/10962/d1018393
- Full Text:
Beasts to beer pots - migrant labour and ritual change in Willowvale district, Transkei
- Authors: McAllister, Patrick A
- Date: 1985
- Language: English
- Type: Article
- Identifier: vital:6112 , http://hdl.handle.net/10962/d1003832
- Description: [From the introduction]: Why do some rituals disappear while others continue to be performed? Why do some persist in a relatively unaltered state while others are radically modified? In an article published in 1978 Monica Wilson drew attention to the scarcity of information on this subject, and proceeded to consider possible reasons for the 'resilience' of certain rituals, such as those accompanying initiation and death, and the 'obliteration' of others, such as those concerning the birth of twins. My concern in this paper is with the persistence and radical modification of a Gcaleka ritual called umhlinzeko or umsindleko, performed in celebration of the return of a migrant worker to his rural home. The earlier form of the ritual (umhlinzeko) is described and this is followed by an outline of the present-day form (umsindleko). The bulk of the paper is taken up with an attempt to explain why the one form gave way to another. In this respect the analysis concentrates on the relationship between the two forms and their socio-economic contexts, and tries to relate the changes in the form and meaning of the ritual to the changing economic and political circumstances affecting the Gcaleka and other Xhosa-speakers.
- Full Text:
- Authors: McAllister, Patrick A
- Date: 1985
- Language: English
- Type: Article
- Identifier: vital:6112 , http://hdl.handle.net/10962/d1003832
- Description: [From the introduction]: Why do some rituals disappear while others continue to be performed? Why do some persist in a relatively unaltered state while others are radically modified? In an article published in 1978 Monica Wilson drew attention to the scarcity of information on this subject, and proceeded to consider possible reasons for the 'resilience' of certain rituals, such as those accompanying initiation and death, and the 'obliteration' of others, such as those concerning the birth of twins. My concern in this paper is with the persistence and radical modification of a Gcaleka ritual called umhlinzeko or umsindleko, performed in celebration of the return of a migrant worker to his rural home. The earlier form of the ritual (umhlinzeko) is described and this is followed by an outline of the present-day form (umsindleko). The bulk of the paper is taken up with an attempt to explain why the one form gave way to another. In this respect the analysis concentrates on the relationship between the two forms and their socio-economic contexts, and tries to relate the changes in the form and meaning of the ritual to the changing economic and political circumstances affecting the Gcaleka and other Xhosa-speakers.
- Full Text:
Breeding condition of male red bishops under artificial photoperiods
- Authors: Craig, Adrian J F K
- Date: 1985
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447761 , vital:74672 , https://doi.org/10.1080/00306525.1985.9639572
- Description: Testis development, as indicated by bill colour changes, and moult were followed over two years in nine birds kept under constant conditions of 14 h light:10 h dark. All birds maintained at least partial nuptial dumage throughout this period, but most continued normal cycles of wing moult. The testes continued to show cycles of enlargement and regression.
- Full Text: false
- Authors: Craig, Adrian J F K
- Date: 1985
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447761 , vital:74672 , https://doi.org/10.1080/00306525.1985.9639572
- Description: Testis development, as indicated by bill colour changes, and moult were followed over two years in nine birds kept under constant conditions of 14 h light:10 h dark. All birds maintained at least partial nuptial dumage throughout this period, but most continued normal cycles of wing moult. The testes continued to show cycles of enlargement and regression.
- Full Text: false
Changes in the image of the feminine from Giotto to Raphael
- Authors: Crossley, Elizabeth Ellen
- Date: 1985
- Subjects: Giotto, 1266?-1337 Feminine beauty (Aesthetics) Women in art
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2471 , http://hdl.handle.net/10962/d1009448
- Description: From Introduction: The ideal of femininity which developed in Renaissance painting, was a visual and psychological type which was to become the Western European Christian formula of the feminine. This type has survived until the present day, so a discussion of its origins can be revealing for us in the twentieth century, especially as it has been neglected in traditional art historical works. In this essay, the changes in the image of the feminine, in just under three hundred years of Florentine painting, starting with Giotto1. and ending with Raphael~· will be covered. The images will be taken from the wo rk of artists who were Florentine in training, who worked in the city or who were strongly influenced by the Florentine style of painting. I have divided the paintings I have studied into three sections. In the Religious section the paintings are mainly of Mary. The Mythological images refer to Greek and Roman myths and the humanistic interpretations of them. Finally, the Portrait and Genre images are selected on the following basis: In the genre paintings they are sometimes part of works related to religion or mythology, but, in their handling, the painters treat the figures as real human beings rather than holy or mythological figures. In others they are bona fide portrait representations. 3. I have made the above distinction because I expect that the gap between religio-mythological images and portraits will give some indication of the difference between the ideal and the reality for women of that time. The images will be analysed and changes noted in favoured types, gestures, expressions, movements, placing in the composition, relationships to others, favoured themes, costume, colour and symbols. I will point out as I proceed the effects that these elements had on the mood and tone of each image.
- Full Text:
- Authors: Crossley, Elizabeth Ellen
- Date: 1985
- Subjects: Giotto, 1266?-1337 Feminine beauty (Aesthetics) Women in art
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2471 , http://hdl.handle.net/10962/d1009448
- Description: From Introduction: The ideal of femininity which developed in Renaissance painting, was a visual and psychological type which was to become the Western European Christian formula of the feminine. This type has survived until the present day, so a discussion of its origins can be revealing for us in the twentieth century, especially as it has been neglected in traditional art historical works. In this essay, the changes in the image of the feminine, in just under three hundred years of Florentine painting, starting with Giotto1. and ending with Raphael~· will be covered. The images will be taken from the wo rk of artists who were Florentine in training, who worked in the city or who were strongly influenced by the Florentine style of painting. I have divided the paintings I have studied into three sections. In the Religious section the paintings are mainly of Mary. The Mythological images refer to Greek and Roman myths and the humanistic interpretations of them. Finally, the Portrait and Genre images are selected on the following basis: In the genre paintings they are sometimes part of works related to religion or mythology, but, in their handling, the painters treat the figures as real human beings rather than holy or mythological figures. In others they are bona fide portrait representations. 3. I have made the above distinction because I expect that the gap between religio-mythological images and portraits will give some indication of the difference between the ideal and the reality for women of that time. The images will be analysed and changes noted in favoured types, gestures, expressions, movements, placing in the composition, relationships to others, favoured themes, costume, colour and symbols. I will point out as I proceed the effects that these elements had on the mood and tone of each image.
- Full Text:
Commission of inquiry to investigate the development of a comprehensive labour market policy
- NUM
- Authors: NUM
- Date: 1985
- Subjects: NUM
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/250662 , vital:52036
- Description: In 1985, the Central Statistical Services and the Chamber of Mines ceased publishing a racial breakdown of mining industry employment. This marked the end of a statistical series that dated back for almost 100 years. Since 1985, there is no official series of racially segmented data for the mining industry, while the racial breakdown of employment in all other sectors of the economy was published up until 1992. From 1993, the Central Statistical Services introduced a new “Unspecified Race” category into its published employment data, making the identification of trends in employment and income by race less certain. The statistical information on racial issues in this submission must reflect these difficulties with the data. In respect of gold and coal mines that are members of the Chamber of Mines, the Chamber periodically has made available unpublished information on employment and total wages after 1985, grouped into “skilled employees” and “unskilled / semi-skilled employees.” Until about 1989, when legal barriers to the employment of blacks in skilled jobs were removed, the two Chamber categories reflect the old “White” and “Non-White” categories used by the Chamber before 1986. Since 1989, a small, but slowly increasing number, of skilled workers have been black, but this has not been taken into account in any of the statistics presented for the gold and the coal sectors. “Black” employment in the gold and coal mining industry thus refers to employees in Categories 1 to 8, the only groups for which the NUM currently bargains with Chamber member mines.
- Full Text:
- Authors: NUM
- Date: 1985
- Subjects: NUM
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/250662 , vital:52036
- Description: In 1985, the Central Statistical Services and the Chamber of Mines ceased publishing a racial breakdown of mining industry employment. This marked the end of a statistical series that dated back for almost 100 years. Since 1985, there is no official series of racially segmented data for the mining industry, while the racial breakdown of employment in all other sectors of the economy was published up until 1992. From 1993, the Central Statistical Services introduced a new “Unspecified Race” category into its published employment data, making the identification of trends in employment and income by race less certain. The statistical information on racial issues in this submission must reflect these difficulties with the data. In respect of gold and coal mines that are members of the Chamber of Mines, the Chamber periodically has made available unpublished information on employment and total wages after 1985, grouped into “skilled employees” and “unskilled / semi-skilled employees.” Until about 1989, when legal barriers to the employment of blacks in skilled jobs were removed, the two Chamber categories reflect the old “White” and “Non-White” categories used by the Chamber before 1986. Since 1989, a small, but slowly increasing number, of skilled workers have been black, but this has not been taken into account in any of the statistics presented for the gold and the coal sectors. “Black” employment in the gold and coal mining industry thus refers to employees in Categories 1 to 8, the only groups for which the NUM currently bargains with Chamber member mines.
- Full Text:
Comparative bioavailability and ranking of topical corticosteroid formulations
- Authors: Meyer, Eric
- Date: 1985
- Subjects: Adrenocortical hormones -- Therapeutic use Drugs -- Bioavailability Drugs -- Dosage forms
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3732 , http://hdl.handle.net/10962/d1001471
- Description: Numerous experiments in recent years have indicated differences in the bioavailability of corticosteroids from seemingly identical topical dosage forms. The human blanching assay was utilized in this study to assess the comparative blanching activities of various locally manufactured proprietary corticosteroid preparations. The first experiment was performed to assess the relative blanching activities of six semi - solid preparations containing the same concentration of betamethasone 17-valerate. The preparations used were Betnovate cream and ointment, Persivate cream and ointment and Celestoderm-V cream and ointment. This was followed, in the second experiment, by the investigation of the blanching activities of two lotions containing betamethasone 17-valerate (Betnovate and Celestoderm-V) and a lotion containing betamethasone 17,21- dipropionate (Diprosone). The third experiment involved a study of six semi-solid proprietary corticosteroid-containing formulations, viz. Dermovate (clobetasol propionate) cream and ointment, Betnovate (betamethasone 17-valerate) cream and ointment and Eumovate (clobetasone butyrate) cream and ointment. This investigation was prompted by claims in advertisements in the medical media that Dermovate is therapeutically more efficacious than Betnovate which is more efficacious than Eumovate. The penultimate experiment in this study served the purpose of finding a corticosteroid-containing preparation that falls into the moderately potent group of corticosteroid formulations, as described in the United Kingdom MIMS. This preparation was used in the final experiment which was undertaken to ascertain the potency category of Florone (diflorasone diacetate) cream and ointment.
- Full Text:
- Authors: Meyer, Eric
- Date: 1985
- Subjects: Adrenocortical hormones -- Therapeutic use Drugs -- Bioavailability Drugs -- Dosage forms
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3732 , http://hdl.handle.net/10962/d1001471
- Description: Numerous experiments in recent years have indicated differences in the bioavailability of corticosteroids from seemingly identical topical dosage forms. The human blanching assay was utilized in this study to assess the comparative blanching activities of various locally manufactured proprietary corticosteroid preparations. The first experiment was performed to assess the relative blanching activities of six semi - solid preparations containing the same concentration of betamethasone 17-valerate. The preparations used were Betnovate cream and ointment, Persivate cream and ointment and Celestoderm-V cream and ointment. This was followed, in the second experiment, by the investigation of the blanching activities of two lotions containing betamethasone 17-valerate (Betnovate and Celestoderm-V) and a lotion containing betamethasone 17,21- dipropionate (Diprosone). The third experiment involved a study of six semi-solid proprietary corticosteroid-containing formulations, viz. Dermovate (clobetasol propionate) cream and ointment, Betnovate (betamethasone 17-valerate) cream and ointment and Eumovate (clobetasone butyrate) cream and ointment. This investigation was prompted by claims in advertisements in the medical media that Dermovate is therapeutically more efficacious than Betnovate which is more efficacious than Eumovate. The penultimate experiment in this study served the purpose of finding a corticosteroid-containing preparation that falls into the moderately potent group of corticosteroid formulations, as described in the United Kingdom MIMS. This preparation was used in the final experiment which was undertaken to ascertain the potency category of Florone (diflorasone diacetate) cream and ointment.
- Full Text:
Computer control of a barry research chirpsounder
- Authors: Evans, Geoffrey Philip
- Date: 1985
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5507 , http://hdl.handle.net/10962/d1007495
- Description: This thesis describes the design and development of a computer-based controller together with additional hardware that greatly extends the capabilities of a Barry Research VOS-1 Chirpsounder. The measurement of the virtual height of the ionosphere as a function of frequency using pulse- and frequency-modulated carrier wave (FMCW techniques is described and the concept of the so called "digital" ionosonde is introduced. The modifications required for the standard Chirpsounder to perform as a versatile digital chirp ionosonde are discussed. Simplified block diagrams are used to describe the Controller hardware which is fully described in two comprehensive service manuals which have been included as appendices. Important aspects of the Controller software and data storage formats are described in detail. The emphasis is then placed on system capabilities. An operators' software manual which describes system initialization and operation in terms of system commands is included as an appendix. Results of tests at both Grahamstown, South Africa , and at the SANAE base in the Antarctic are presented.
- Full Text:
- Authors: Evans, Geoffrey Philip
- Date: 1985
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5507 , http://hdl.handle.net/10962/d1007495
- Description: This thesis describes the design and development of a computer-based controller together with additional hardware that greatly extends the capabilities of a Barry Research VOS-1 Chirpsounder. The measurement of the virtual height of the ionosphere as a function of frequency using pulse- and frequency-modulated carrier wave (FMCW techniques is described and the concept of the so called "digital" ionosonde is introduced. The modifications required for the standard Chirpsounder to perform as a versatile digital chirp ionosonde are discussed. Simplified block diagrams are used to describe the Controller hardware which is fully described in two comprehensive service manuals which have been included as appendices. Important aspects of the Controller software and data storage formats are described in detail. The emphasis is then placed on system capabilities. An operators' software manual which describes system initialization and operation in terms of system commands is included as an appendix. Results of tests at both Grahamstown, South Africa , and at the SANAE base in the Antarctic are presented.
- Full Text:
Concurrency in modula-2
- Authors: Sewry, David Andrew
- Date: 1985 , 2013-03-13
- Subjects: Modula-2 (Computer program language) , Programming languages (Electronic computers) , Computer multitasking
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4582 , http://hdl.handle.net/10962/d1004369 , Modula-2 (Computer program language) , Programming languages (Electronic computers) , Computer multitasking
- Description: A concurrent program is one in which a number of processes are considered to be active simultaneously . It is possib l e to t hink of a process as being a separate sequential program executing independently of other processes, although perhaps communicating with them at desired pOints . The concurrent program, as a whole, can be executed in one of two ways: il ii) in true concurrent manner, wi th each process executing on a dedicated processor in a quasi - concurrent manner, where a processor's processes . time is multiplexed between single the There are two motivations for the study of concurrency in programming languages : i) concurrent programming facilities can be exploited in systems where one has more t han one processor . As technology i mproves, machines having multiple processors will proliferate ii) concurrent p r ogramming facilities may allow programs to be structured as independent , bu t co - operating, processes which can then be implemented on a single processor system . This structure may be more natural to the programmer then the traditional sequential structures. An example is provided by Conway's - 1- Clearly, languages Pascal) problem [Ben82] . by their very nature, traditional sequential- type (Fortran, Basic, Cobol and earlier versions of prove inadequate for the purposes of concurrent programming without considerable extension (which some manufacturers have provided, rendering their compilers non standard-conforming). The general convenience of high level languages provides strong motivation for their development for rea l time programming. Modula - 2 [Wir83] is but one of a number of such r ecently developed languages, designed not only to fulfil a "sequential" role but also to offer facilities for concurrent programming. Developed by Niklaus Wirth in 1979 as a successor to Pascal and Modula, it is intended to serve under the banner of a generalpurpose systems - implementation language. This thesis investigates concurrency i n Modula - 2 and takes the following form: i ) an analYSis of the concurrent facilities offered ii) problems and difficulties associated with these facilities iii) improveme nts and enhancements, including the feasibility of using Modula - 2 to simulate constructs found in other languages, such as the Hoare monitor [Hoa74] and the Ada rendezvous [Uni81]. - 2- Each section concludes with an appraisal of the work conducted in that section . The final section consists of a critical assessment of those Modula - 2 language constructs and facilities provided for the implementation of concurrency and a brief look at concurrency in Modula, Modula-2's predecessor. - Introduction. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Authors: Sewry, David Andrew
- Date: 1985 , 2013-03-13
- Subjects: Modula-2 (Computer program language) , Programming languages (Electronic computers) , Computer multitasking
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4582 , http://hdl.handle.net/10962/d1004369 , Modula-2 (Computer program language) , Programming languages (Electronic computers) , Computer multitasking
- Description: A concurrent program is one in which a number of processes are considered to be active simultaneously . It is possib l e to t hink of a process as being a separate sequential program executing independently of other processes, although perhaps communicating with them at desired pOints . The concurrent program, as a whole, can be executed in one of two ways: il ii) in true concurrent manner, wi th each process executing on a dedicated processor in a quasi - concurrent manner, where a processor's processes . time is multiplexed between single the There are two motivations for the study of concurrency in programming languages : i) concurrent programming facilities can be exploited in systems where one has more t han one processor . As technology i mproves, machines having multiple processors will proliferate ii) concurrent p r ogramming facilities may allow programs to be structured as independent , bu t co - operating, processes which can then be implemented on a single processor system . This structure may be more natural to the programmer then the traditional sequential structures. An example is provided by Conway's - 1- Clearly, languages Pascal) problem [Ben82] . by their very nature, traditional sequential- type (Fortran, Basic, Cobol and earlier versions of prove inadequate for the purposes of concurrent programming without considerable extension (which some manufacturers have provided, rendering their compilers non standard-conforming). The general convenience of high level languages provides strong motivation for their development for rea l time programming. Modula - 2 [Wir83] is but one of a number of such r ecently developed languages, designed not only to fulfil a "sequential" role but also to offer facilities for concurrent programming. Developed by Niklaus Wirth in 1979 as a successor to Pascal and Modula, it is intended to serve under the banner of a generalpurpose systems - implementation language. This thesis investigates concurrency i n Modula - 2 and takes the following form: i ) an analYSis of the concurrent facilities offered ii) problems and difficulties associated with these facilities iii) improveme nts and enhancements, including the feasibility of using Modula - 2 to simulate constructs found in other languages, such as the Hoare monitor [Hoa74] and the Ada rendezvous [Uni81]. - 2- Each section concludes with an appraisal of the work conducted in that section . The final section consists of a critical assessment of those Modula - 2 language constructs and facilities provided for the implementation of concurrency and a brief look at concurrency in Modula, Modula-2's predecessor. - Introduction. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
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