In vitro permeation of progesterone from a gel through the shed skin of three different snake species
- Authors: Haigh, John M , Beyssac, E , Chanet, L , Aiache, J M
- Date: 1998
- Language: English
- Type: Article
- Identifier: vital:6366 , http://hdl.handle.net/10962/d1006066
- Description: The in vitro diffusion of progesterone from a gel formulation using the European Pharmacopoeia method for transdermal dosage forms is described. The membranes used were the dorsal and ventral portions of the shed skin of three different species of snake. Considerable differences are apparent between the dorsal and ventral sites and between the different species of snake. The dorsal area shows better permeability for progesterone and the permeability order for the different species is python>cobra>viper. These differences may be due to the thickness of the skin and the hinge:scale ratio. The results indicate that shed snake skin is not a model membrane for human skin.
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In vitro release of amoxycillin from lipophilic suppositories
- Authors: Webster, Jessica A , Dowse, Roslind , Walker, Roderick B
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184377 , vital:44213 , xlink:href="https://doi.org/10.3109/03639049809085636"
- Description: The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semisynthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 ± 8.18 and 99.66 ± 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 ± 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 ± 0.27%).
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Interaction of nitric oxide with cobalt (II) phthalocyanine
- Authors: Vilakazi, Sibulelo L , Nyokong, Tebello
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/293579 , vital:57100 , xlink:href="https://doi.org/10.1016/S0277-5387(98)00244-7"
- Description: The coordination of nitric oxide (NO) to cobalt(II) phthalocyanine (CoPc) in dimethyl sulphoxide (DMSO) has been studied. CoPc coordinates with NO in a 1:1 ratio, forming a CoPc(NO) species. The IR band observed at 1680 cm−1 is assigned to the coordinated NO. In the presence of excess NO, pseudo first order kinetics were followed. The observed rate constant, kf, was determined to be 15.0±0.3 dm−3 mol−1 s−1 and the equilibrium constant was K=5.4±0.4×104dm3 mol−1. Solution or adsorbed CoPc catalyses the reduction of NO. The products of reduction include NH3 and NH2OH.
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Legislative provisions, origins, and transformative possibilities
- Authors: NALEDI
- Date: 1998
- Subjects: NALEDI
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/151359 , vital:39058
- Description: This research report was commissioned by NALEDI as part of its long term research project on Co-determination and Tripartism in South Africa. The transition to democracy in South Africa has been accompanied by a range of institutions and processes through which ordinary workers and their organisations may gain varying degrees of control over economic decisions that directly affect their lives. Scholars and practitioners have focussed attention on parts of these changes - such as NEDLAC or the workplace forum provisions of the Labour Relations Act - while missing its more systematic features: its wide scope from the factory floor to the societal level, and the extent to which labour has obtained strong decisionmaking and consultation rights founded in both statute and agreement. Taken together these features have the potential to deepen dramatically the political democracy won in 1994. Yet these developments are generally untheorised and remain seriously underresearched. In mid-1996 NALEDI embarked on this long term research project to investigate the dramatic changes that are occurring regarding worker representation at the workplace, industry, and societal levels. The full list of reports produced by this project is set out below. While the contributions are academically informed, they are aimed at examining key issues in a critical fashion to inform trade unionists and contribute to labour movement policy debates.
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Managing natural resources in a rural settlement in Peddie district
- Authors: Ainslie, Andrew
- Date: 1998
- Subjects: Conservation of natural resources -- South Africa -- Management , Natural resources -- South Africa -- Peddie District -- Management , Peddie (South Africa) -- Social conditions , Peddie (South Africa) -- History
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2110 , http://hdl.handle.net/10962/d1007462 , Conservation of natural resources -- South Africa -- Management , Natural resources -- South Africa -- Peddie District -- Management , Peddie (South Africa) -- Social conditions , Peddie (South Africa) -- History
- Description: This thesis is an account of the challenges people in Tyefu Location, Peddie District, and specifically in Gwabeni village, face in their attempts to manage their common pool natural resources. Taking my analytical cue from the literature which deals with the institutional dimensions of resource management in common property systems, I look at the impact of both outside influences and local dynamics on resource managing institutions at village level. I show how particular historical circumstances, including state interventions, led to the enclosure of Tyefu Location, and to the rapid increase in the population that had to be accommodated here. This placed enormous pressure on the natural resources of the area, and contributed to the emasculation of the local institutions responsible for overseeing resource management. The residents of the location adopted whatever strategies they could to ameliorate the depletion of natural resources in their villages. One 'traditional' strategy they have sought to emulate is to move their imizi (homesteads) away from areas where local resources has been exhausted. Given the finite area of land available to them, this strategy was only ever likely to be successful in the short-term. I analyse social, economic and institutional factors at village level that appear to act as disincentives to collective resource management activities. These factors include the social structure of the imizi and the socio-economic heterogeneity that exists between imizi in Gwabeni village. The varying degrees of household economic marginality that follow from this, together with the differential ownership of livestock and other possessions that decrease people's reliance on locally available natural resources, mean that the transaction costs that people would incur by contributing to collective resource management activities, differ widely. A primary cause of people's failure to engage in resource management at village level stems from the dispersion of the members of their imizi. This factor robs the village of decision makers and undermines the capacity of those left behind to make and implement resource management decisions. It results in the various members of imizi in the village having different orientations that dissipate the energy needed for collective action. It also fuels existing struggles, and creates new ones, over the meanings and uses of the term 'community'. I conclude by arguing that, in Tyefu Location, the management of natural resources is extremely difficult to co-ordinate, because such management is highly contested, undermined by differentiation among resource users, and subject to the attentions of weak village institutions that do not share a clear set of resource management objectives. , KMBT_363
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Media reach and reception in development communication: the case of the Rural Industries Innovation Centre in Botswana
- Authors: Maleke, Jackson Mogopodi
- Date: 1998
- Subjects: Rural Industries Innovation Centre (Kanye, Botswana) , Communication in rural development , Mass media in community development
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3455 , http://hdl.handle.net/10962/d1002909 , Rural Industries Innovation Centre (Kanye, Botswana) , Communication in rural development , Mass media in community development
- Description: The study was conducted in Phitshane-Molopo in Botswana. Phitshane-Molopo is located about 115 kilometers south of the main village of Kanye in which the Rural Industries Innovation Centre operates. The study constitutes the first attempt at evaluating audience reach and reception of the RIIC media messages. In this study, a sample of 50 representatives of households (the rationale is covered in chapter 1) was taken, for which a questionnaire was administered, including conducting in-depth interviews with key informants. The study found that RIlC media are not reaching the audience in keeping with the corporate goals and assumptions on the basis of which the communication strategy was established. The audience has claimed that the print media relayed to them through the extension officer channel do not reach them. The study also found that the audience possessed adequate literacy skills and the majority of them could read materials produced in Setswana. Only a few individuals preferred media text produced in the English language. The study therefore deplores RIIC's proclivity towards producing its media texts only in the English language. This has tended to marginalise members of the audience who cannot read in English. It is thus hoped that this study would provide a learning experience for RIIC to consider producing its communication media in relation to the needs of the audience. The study also found that the impact of the RIIC radio programme is very poor, with only a low of 2% of the sample population having listened to this programme. The problem stems from the poor Radio Botswana transmission system. The audience said that for the larger part of the day, they can't get Radio Botswana on air. As a result, they have shifted their interest to the South African radio stations such as Radio Tswana and Radio Mmabatho, which are constantly on air. The study concludes that the RIIC communication strategy is failing in the study area because the paradigm in which it is located is somewhat flawed, as a result of which it does not effectively impact upon reach and reception. At the core of this failure rate are implementation problems and the lack of evaluation that would have picked up the - problems earlier, for which solutions would have been found. Consequently, th~$tudy recommends the need to explore the suitability and effectiveness of the indigenous media for possible syncretization with conventional media as recommended in the need based integrative model (Nwosu and Megwa: 1993). Indigenous media are ideally suited to rural communication needs because they are consistent with the socio-cultural expectations of the audience. RIIC therefore stands to benefit from these media because the bulk of its audience resides in rural areas.
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Medical Aid plan
- Authors: SACCAWU
- Date: 1998
- Subjects: SACCAWU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/137694 , vital:37550
- Description: THE South African Commercial Catering and Allied Workers Union (Saccawu) launched a medical aid fund yesterday which the union said would be used as a springboard for the establishment of its own medical aid scheme. Saccawu assistant general secretary Herbet Mkhize said the fund would operate under Medscheme’s Meddent Medical Scheme for about nine months while the union conducted further research into establishing its own medical aid scheme. Mkhize said trade unions were no longer only competing with one another but also with legal firms that were now offering their services to workers. “Now a trade union has to convince potential members that it offers the best services, “Mkhize said.
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Morphological and genetic differentiation of Patella granularis (Gastropoda: Patellidae): recognition of two sibling species along the coast of southern Africa
- Authors: Ridgway, Tyronne M , Stewart, Barbara A , Branch, George M , Hodgson, Alan N
- Date: 1998
- Subjects: Patellidae
- Language: English
- Type: Article
- Identifier: vital:6944 , http://hdl.handle.net/10962/d1011971
- Description: Morphological and isozyme variations between 13 populations of the species hitherto named Patella granularis were investigated to see whether differences in shell structure between the west coast versus the south and east coasts of southern Africa are supported by other morphological features or by genetic differences. The shells showed a definite decrease in size from west to east, but this is correlated with productivity and is of no diagnostic use in distinguishing between populations. Discriminant functions analysis based on shell morphometrics failed to separate populations from the three coastal regions. Shells from the northern east coast do, however, have shell nodules with a dark pigmentation, distinctly separating them from those further south and west. No differences in radular or soft part morphology were detected between the populations, but the four northernmost populations on the east coast have a significantly shorter Z looping of the gut than the other populations along the coast. Significant microstructural differences in the sperm were also detected between these two groups of populations. Electrophoretic analysis of 16 enzyme loci failed to detect any significant differences between the west and south coast populations, but revealed a genetic identity (Nei) of 0.528 as well as four diagnostic alleles between the four northernmost populations from the east coast compared with those to the south and west. The two genetically distinct forms occurred sympatrically at one of the study sites on the east coast (Coffee Bay). It was concluded the two groupings were sufficiently different to warrant the recognition of a separate species, which is centred in KwaZulu-Natal on the east coast and extends south to Coffee Bay, from where it is replaced by P. granularis. There is, however, no evidence at all that the west coast populations are in any way separable from the remaining populations of P. granularis on the south coast.
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Morphometrics and preliminary biology of the caridean shrimp Nauticaris marionis Bate, 1888, at the Prince Edward Islands (South Ocean), 37° 50'E, 46° 45'S
- Authors: Kuun, Patrick John
- Date: 1998
- Subjects: Shrimps -- Prince Edward Islands
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5733 , http://hdl.handle.net/10962/d1005419 , Shrimps -- Prince Edward Islands
- Description: Carapace length, as the best measure of N. marionis body size, is precisely defined. It is shown that N. marionis is a partially protandric hermaphrodite. N. marionis appear to hatch just before April each year, with a little hatching persisting until May. The vast majority of juveniles develop into males. The majority of males transmutate into females in their third year. By April/May the transmutation is probably complete. Reproduction can occur before all male secondary characteristics have been lost. A small minority of individuals develop directly into females without passing through a male phase. At least some of these females can be initially recognized after they have developed mature ovaries by the presence of appendices internae on their first pleopods, a male copulatory structure which all juvenile N. marionis possess. Too few gravid females were recovered to make any statement on whether spawning can occur before this structure is lost. Such females may lose their first pleopod appendices internae in one moult, possibly just before spawning, which may be in late April/early May. Such individuals seem to mature into ovigerous females at a slightly smaller carapace length than do the majority of females which have had a male-phase past. A few females which have passed through a male phase seem to begin developing ovaries at about this small carapace length as well. Once the appendices internae have been lost there appears to be no way of identifying any given female's past life-history. It would seem that during the first year of life N. marionis survive in undetected localities, moult into juveniles, and then settle amongst the benthos from the plankton. Diurnal vertical migration then occurs up to an unknown larger size. It is not known whether the larvae are initially planktonic or not. It is possible that settling of small N. marionis onto the benthos only begins after November. Whether the appendices masculinae of some males only begin growing after they have settled Abstract XIX onto the benthos is unknown, but for the majority at least this begins whilst they are planktonic juveniles. Individuals older than five years are undetectable using samples of the sizes analyzed in this thesis, but they may well persist until quite an advanced age. Niche separation between smaller and larger N. marionis individuals may occur. Diel vertical migration may occur to some extent amongst large N. marionis. Itinerant euphausiids may contribute substantially to the maintenance of top predator populations at the archipelago, either through direct predation by those predators or via predation by N. marionis, which in turn are consumed by those predators. N. marionis itself is an opportunistic feeder, although the majority of its prey seem to be suspension feeders, both benthic and pelagic. In multisample situations, ageing of N. marionis cohorts is made less subjective if one utilizes the phenomenon of synchronized sexual inversion. The von Bertalanffy growth parameters for N. marionis are tentatively identified as k = 0.2353/year, L_ = 12.69mm, to = -0.2828 years and WW_ = 2.03g. The programme FiSAT is discussed, having been found to be extremely useful, but having also been found to have certain faults. Various hypotheses are proposed and are put forward as suggestions for future studies.
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Natural resources and local management in the Hewu District of the Eastern Cape : limitations to achieving sustainability
- Authors: Nkansa-Dwamena, Yaw
- Date: 1998
- Subjects: Natural resources -- South Africa -- Management , Natural resources -- South Africa -- Eastern Cape -- Management
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4218 , http://hdl.handle.net/10962/d1003787 , Natural resources -- South Africa -- Management , Natural resources -- South Africa -- Eastern Cape -- Management
- Description: The Mceula Commonage Land in the Hewu district lies due northwest of Whittle sea and west of Queenstown in the Eastern Cape. This thesis has two main objectives. Firstly, to survey and analyse the condition of the natural resource. base in the Hewu district with particular reference to water, soil, vegetation and land use. Secondly, to investigate the relationship between scientific approaches to assessing land use degradation and to compare these to the results obtained using a participatory approach of the rural environment of the Hewu district of the Eastern Cape. Random quadrats (4m2) were sampled and corresponding line transects were done with increasing distances from the villages. The Braun-Blanquet method was used to find the cover and abundance of the various species of plants. Data obtained from point sampling along 100 metre line transects was used to assess the condition of the veld using Trollope's technique. Six communities were defined using TWINSP AN, and grazing capacities and veld condition scores of the respective sites were calculated. It was concluded that the six communities were distributed along a gradient of palatable to non palatable grass and grasslike species. Rangelands close to the villages had low veld condition scores and percentage plant cover as opposed to those farther away from the villages. The null hypothesis of no significant difference between the percentage plant cover and condition of the veld close to the villages and farther away from the villages was rejected. Whilst it is urgent to resolve political disputes around land through land distribution, a key issue for the future is sustainability of the natural resource base of South Africa. To attain this, the old traditional methods of research must be supplemented with the participatory method, where the local community becomes fully involved. The central theme of the participatory approach was to investigate the possibility of promoting local management of the natural resources. Workshops were conducted to involve the local community in the project. The community formed six discussion groups that met regularly to discuss environmental issues. The six groups that were formed were: Firewood or woodlot collectors, shepherds / livestock raisers, crop fanners / agriculturists, water collectors, building material / soil collectors and medicinal plant users. The results obtained from the meeting of the discussion groups were used to compare the scientific results obtained from Braun-Blanquet method. Perceptions about their environment, which came out of the results of the discussion groups showed that the local knowledge of the rural community of Mceula was sufficient to train them to manage their environment sustainably.
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New developments in the methodology available for the assessment of topical corticosteroid-induced skin blanching
- Authors: Haigh, John M , Smith, Eric W , Maibach, Howard I
- Date: 1998
- Language: English
- Type: text , Article
- Identifier: vital:6384 , http://hdl.handle.net/10962/d1006305
- Description: Since the publication of the previous edition of this book there have been considerable developments and controversy in the field of topical corticosteroid bioequivalence assessment. There has been considerable discussion in the literature concerning the use of the Minolta chromameter for the measurement of corticosteroid-induced skin blanching, as it is believed this instrument would produce more objective results than the visual grading procedure. These efforts culminated in the release of a guidance document from the Food and Drug Administration (FDA) detailing the procedures to be followed for the determination of topical corticosteroid bioequivalence using the chromameter. Since the promulgation of this document there have been challenges on the validity and scientific merit of the documented procedures, and recently the FDA itself conceded that it may be necessary to redefine some of the protocol evaluations. This chapter attempts to redefine the current standing of the two methods of response assessment.
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New rules for security and survival: Southern Africa's adaptation to a changing world environment
- Authors: Naidoo, Sagaren Krishna
- Date: 1998
- Subjects: Internal security -- South Africa , National security -- South Africa , South Africa -- Politics and government -- 1994- , South Africa -- Economic conditions -- 1991-
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2814 , http://hdl.handle.net/10962/d1003024 , Internal security -- South Africa , National security -- South Africa , South Africa -- Politics and government -- 1994- , South Africa -- Economic conditions -- 1991-
- Description: In the wake of the post-Cold War era, students of international relations were forced to review their theoretical frameworks to explain new rules for international peace and security. States are now confronted with new constraints for their security and survival as current trends in international politics depict a 'regionalisation' of peace and security. For southern Africa, likewise, the end of the Cold War and, moreover, apartheid, compels its member states to redefine their security strategies and mechanisms for survival. This thesis undertakes to examine southern Africa's adaptation to new rules of a changing world environment, to ensure a stable and secure region, into the next millennium. At the outset of this thesis lies a conceptual contextualisation of security within the major contemporary theoretical approaches of international relations. By examining the essential differences between the redefinitions and new conceptualisations of security, this thesis, firstly argues that the state in southern Africa must be retained as a primary referent of security. This argument is premised on the need to create stronger states for a 'regionalisation' of security in southern Africa. The second issue examined is the changing world environment and its impact on the state and development in Africa, as the new constraints to which the continent must adapt, for security and survival. Arguing that the new international economic order and 'globalisation' dictate the new rules, this chapter asserts that the 'weak' states in Africa need to be strengthened to have the necessary capacity to be the means for its people's security. Finally this thesis examines the new rules for southern Africa's adaptation to a changing world environment. The new rules for the African sub-continent involve the formation of a security regime and economic community with, the power-house, South Africa. Using the Southern African Development Community(SADC) as the umbrella body, the formation of the Organ for Politics, Defence and Security, and signing of trade protocols for a movement towards a free trade area, are evidence of southern Africa's attempts to adapt to new rules for its security. Such adaptation cannot, however, be accomplished with 'weak' states. Southern African states will have to, therefore, be strengthened to attain a more secure adaptation to the new international (economic) order.
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Nifedipine-cyclodextrin binary systems : solid-state photostability and dissolution behaviour
- Authors: Worthington, Matthew Stanley
- Date: 1998
- Subjects: Nifedipine Calcium -- Antagonists Cyclodextrins Cyclodextrins in pharmaceutical technology
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3830 , http://hdl.handle.net/10962/d1007233
- Description: Nifedipine is a photolabile calcium channel antagonist which undergoes rapid photodegradation in solution and in solid-state with an accompanying loss of pharmacological potency and clinical efficacy. Nifedipine photostabilization which has received considerable attention has principally been achieved by physical obscuration and through the use of colourants or ultraviolet light absorbers incorporated into liquid preparations, translucent packaging materials, gelatin capsules and/or their fillings and tablet coatings or cores. This study was initiated by a South African pharmaceutical manufacturer in response to increasing evidence that cyclodextrin (CD) inclusion complexation may improve drug photostability. The brief was to evaluate the potential of selected cyclodextrins as photoprotecting agents for nifedipine in the solid-state. Areas of investigation included i) quantitative method development and validation for selective determination of nifedipine, ii) phase solubility studies to establish the solubilizing potential and complexing tendencies of selected cyclodextrins, iii) preparation of solid-state nifedipine - cyclodextrin binary systems using an industrially applicable method, iv) pre-formulation photostability studies to determine the effects of the cyclodextrins on solid-state nifedipine photostability and v) comparative in vitro dissolution assessments of nifedipine, the nifedipine - cyclodextrin binary systems and their respective physical mixtures. Phase solubility studies demonstrated that soluble nifedipine - cyclodextrin complexes were formed in aqueous solution, but the magnitude of the interactions were generally low as reflected by the calculated stability constants which decreased in the rank order, heptakis (2,6-dimethyI)-β-CD (DM-β-CD) > randomly methylated-β-CD (RM-β-CD) > β-CD ≈ 2-hydroxypropyl-β-CD (2HP-β- CD) > γ-CD ≥ 2-hydroxypropyl-γ-CD (2HP-γ-CD). An industrially applicable kneading method yielded binary systems with spectral and thermal characteristics similar to the respective physical mixtures, implying weak solid-state inclusion complexation. Preparation of an amorphous nifedipine - RM-β-CD product using a heating method is reported. A 1.7- and 1.9-fold improvement in solid-state nifedipine photostability was observed for I : 1 molar ratio β-CD and γ-CD kneaded products, respectively, when exposed to window-filtered daylight and could be attributed to changes in opacity of the crystalline kneaded products. The remaining cyclodextrins produced negligible nifedipine photostabilization. Nifedipine in vitro dissolution was improved considerably from γ-CD and RM-β-CD .kneaded products as a result of increased nifedipine wettability, solubility and reduced particle size. iii
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NUM - Induction course participants manual
- Authors: NUM
- Date: 1998
- Subjects: NUM
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/149554 , vital:38863
- Description: This Induction Course is the most important education programme in the National Union of Mineworkers. It is the beginning of a development programme for shaft/shop stewards as cadres of the labour movement and cadres of the working class movement. The Induction Course is part of a programme to organise, deepen organisational understanding, raise class-consciousness and develop working class leadership. Once a shaft/shop steward has completed the course, he/she must demand progression through the intermediate course to the leadership school. Development and desire for selfgrowth should be in the hands of stewards themselves. We train shaft/shop stewards because we are committed to ensuring that Mine and Energy workers themselves determine their destiny. They must lead and control their own union. This can only become reality if it translates into these workers taking over all strategic positions in the union. The Induction Course must instill ambition and make our members develop dreams about the union.
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Patterns of marine harvest effort in southwestern New Georgia, Solomon Islands: resource management or optimal foraging?
- Authors: Shankar, Aswani
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439971 , vital:73724 , xlink:href="https://doi.org/10.1016/S0964-5691(98)00047-7"
- Description: Numerous researchers in the field of maritime anthropology have accepted the notion that marine tenure institutions are cultural systems designed to conserve marine resources. This idea has attained wide acceptance without the development of an ecological model to account for the occurrence of conservation and/or depletion of resources. In this study, foraging theory is offered as an alternative theoretical framework to examine the diversity of human resource exploitation strategies in coastal ecosystems. The results generated by the foraging models are considered here in relation to their significance in linking ecological evolutionary approaches in anthropology with coastal resource management.
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Pension payouts, periodic marketing and the continuance of urban dependence in rural South Africa
- Authors: Fox, Roddy C , Nel, Etienne L
- Date: 1998
- Language: English
- Type: Article
- Identifier: vital:6681 , http://hdl.handle.net/10962/d1006675
- Description: The former homeland areas of South Africa are characterised by extreme poverty, high levels of urban dependence, a reliance on pensions and low levels of agricultural production. This paper is based on a case-study of the Eastern Cape province and details rural realities, the importance of pensions and the constraints which face current plans to develop and expand the periodic marketing network.
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Photoassisted reduction of thionyl chloride by neodymium, europium, thulium and lutetium diphthalocyanines
- Authors: Nensala, Ngudiankama , Nyokong, Tebello
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/293590 , vital:57101 , xlink:href="https://doi.org/10.1016/S0277-5387(98)00133-8"
- Description: Diphthalocyanine complexes of Nd III, EuIII, TmIII and LuIII ( [Pc (−2) Nd IIIPc (−2) ] −, [Pc (−2) EuIIIPc (−2) ] −, [Pc (−2) TmIIIPc (−2) ] − and [Pc (−2) LuIIIPc (−2) ] −, respectively) , undergo one or two-electron oxidation in the presence of thionyl chloride. The oxidation products depend on the concentration of the thionyl chloride. At low concentrations of SOCl2 (larger than 10−4 mol dm−3) one-electron oxidation occurs only upon photolysis, giving the neutral lanthanide diphthalocyanine, Pc (−2) LnPc (−1) , complexes. The Pc (−2) LnPc (−1) species undergo one-electron photooxidation to the [Pc (−1) LnPc (−1) ] + in dichloromethane and in the presence of SOCl2. At large concentrations of SOCl2 (>10−2 mol dm−3) , two electron oxidation of the [Pc (−2) LnPc (−2) ] − species directly to [Pc (−1) LnPc (−1) ] + occurs.
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Pictograms in pharmacy:
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 1998
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157048 , vital:40082 , https://0-doi.org.wam.seals.ac.za/10.1111/j.2042-7174.1998.tb00924.x
- Description: This review examines the use of pictograms in health care. Well designed pictograms are simple, clear, graphic symbols able to convey their intended meaning to all patients, including those who are illiterate, elderly or visually impaired. Although some research on the effectiveness of pictograms has not supported the hypothesis that pictograms are beneficial for the acquisition and comprehension of information, most studies investigating health‐related applications of pictograms have shown them to be of benefit in the comprehension and recall of instructions on prescription and over‐the‐counter medicines. However, the success of pictograms as a communication aid in pharmacy depends first on a rigorous design process, followed by well‐designed, randomised, controlled trials using an appropriate method of evaluation. The final stage is to investigate the optimal way of using pictograms in practice and to assess their effect on behavioural outcomes, such as compliance.
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Port Elizabeth History: A Select Annotated Bibliography
- Authors: Baines, Gary F
- Date: 1998
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125742 , vital:35813 , https://doi.10.1080/02582479808671323
- Description: When I commenced my work on aspects of Port Elizabeth’s history in the late 1980s, there was no body of scholarly literature on which to draw. Since thena number of significant publications, both periodical articles and books, as well as theses have appeared, and something of a corpus of works on the city now exists. It seems appropriate to take stock of the current state of Port Elizabeth’s historiography by compiling a bibliography.
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Precision of tristimulus chromameter results from corticosteroid-induced skin blanching
- Authors: Smith, Eric W , Haigh, John M
- Date: 1998
- Language: English
- Type: Conference paper
- Identifier: vital:6342 , http://hdl.handle.net/10962/d1006609
- Description: The human skin blanching (vasoconstriction) assay has been in use for 3 decades as a tool for the assessment of the release of corticosteroids from topical dosage forms. Application of corticosteroids produces a whitening (blanching) of the skin, the intensity of which is directly related to the clinical efficacyof the formulation. Assessment of the intensity of the induced blanching has classically been, and continues to be, pe1fonned by visual grading, a method which has been criticised because of the subjectivenature of the assessment Recently there has been considerablediscussion in the literature regarding the use of the chromameter as an objective instrumental method of monitoring corticosteroid induced skin blanching for bioequivalence assessment purposes. The FDA has released a Guidance document recommending the use of the chromameter for this purpose. The chromameter measures colour in teims of three indices: the L-scale (light-dark), the a-scale (red-green) and the b-scale (yellow-blue).Any colour can be expressedabsolutelyin terms of these three values.The Guidance protocol suggests the use of only the a-scale values in quantifying the blanching response after correction of the data which includes subtraction of baseline and unmedicated site values. One of the unresolved issues in the FDA Guidance document is this method of data manipulation suggested since the instrument should be capable of assigning an absolute colour value to each site during the vasoconstriction period. The purpose of this study was to manipulate the instrumental data from a typical blanching study in a number of ways to investigate the appropriatenessof these suggested procedures.
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