List of Titles

Quinolone-isoniazid hybrids: Synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation

- Beteck, Richard M, Seldon, Ronnett, Khanye, Setshaba D, Legoabe, Lesetja J, Hoppe, Heinrich C, Laming, Dustin, Jordaan, Audrey, Warner, Digby F

Authors: Beteck, Richard M , Seldon, Ronnett , Khanye, Setshaba D , Legoabe, Lesetja J , Hoppe, Heinrich C , Laming, Dustin , Jordaan, Audrey , Warner, Digby F
Date: 2019
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/123151 , vital:35410 , https://doi.org/10.1039/C8MD00480C
Description: Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2–8 μM without any cytotoxic effects. Compounds 10 (MIC90; 0.9 μM), 11 (MIC90; 0.2 μM), 12 (MIC90; 0.8 μM) and compound 15 (MIC90; 0.8 μM), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions −1 and −3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
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Date Issued: 2019

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Beneficial effects of medicinal plants in fish diseases

- Stratev, Deyan, Zhelyazkov, Georgi, Noundou, Xavier S, Krause, Rui W M

Authors: Stratev, Deyan , Zhelyazkov, Georgi , Noundou, Xavier S , Krause, Rui W M
Date: 2018
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/126177 , vital:35856 , https://doi.org/10.1007/s10499-017-0219-x
Description: Fish are constantly in contact with pathogens inhabiting water. High populationdensity as well as poor hydrodynamic conditions and feeding lead to an increased sensitivitytowards infections. In order to prevent major economic losses due to diseases, variousmedications are used for treatment and prevention of infections. The use of antimicrobialdrugs in aquacultures could lead to emergence of resistance in pathogenic microorganisms.Alternatives are being sought over the last few years to replace antibiotics, and medicinalplants are one of available options for this purpose. These plants are rich in secondarymetabolites and phytochemical compounds, which have an effect against viral, bacterial, andparasitic diseases in fish. Their main advantage is their natural origin and most of these plantsdo not represent threat for human health, the fish, and the environment. The goal of this reviewis to present information on the treatment of viral, bacterial, and parasitic diseases in fishthrough medicinal plants, with focus on the mechanisms of action of the identified secondarymetabolites, fractions, or plant extracts.
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Date Issued: 2018

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The role of psychosocial factors in academic performance of first year psychology students at a historically white university

- Dlamini, Sipho Solomon

Authors: Dlamini, Sipho Solomon
Date: 2017
Subjects: Rhodes University -- Students , Academic achievement , Undergraduates -- South Africa , Dropouts -- South Africa , College students -- South Africa , Psychology students -- South Africa , Minorities -- Education -- South Africa
Language: English
Type: Thesis , Masters , MA
Identifier: http://hdl.handle.net/10962/5150 , vital:20781
Description: The success rate of students in higher education has been a cause for concern in South Africa (Letseka & Maile, 2008; Department of Higher Education and Training, 2015). This has been particularly concerning for first-year students, where the rate of attrition is especially high (Letseka, Cosser, Breier, and Visser, 2010). A number of factors have been identified in past research as having an effect on academic performance, which influences attrition and graduation. These factors include age (Justice, & Dornan, 2001), gender (Buchmann, & DiPrete, 2006), socio-economic status which is confounded by race (Letseka & Breier, 2008), type of educational background (Spreen, & Vally, 2006), and whether a student is a domestic or international student (Li, Chen, Duanmu, 2009), social capital (Young & Strelitz, 2014), whether the student is a first language speaker of the language of instruction at the university (Snowball, and Boughey, 2012), student wellbeing (Quinn, & Duckworth, 2007), locus of control (Findley, & Cooper, 1983), and frequency of lecture attendance (van Wallbeek, 2004). The study was conducted at Rhodes University, a small historically white South African institution. For this study, academic performance was measured using the participant’s midyear exam results for an introductory psychology cause, a course that straddles faculties. Of the 690 students registered for the course, 361 (52%) completed an electronic survey that explored the various factors associated with academic performance. A hierarchical regression analysis indicates that pre-university factors (age, gender, race, nationality, language, type of school, and socio-economic status) were the only significant predictors of academic performance, contributing 11% of the effect. Race and nationality, when all the other factors were controlled for, were the only predictors of academic performance. The implications of these findings pose troubling questions of the institutional culture at the university.
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Date Issued: 2017

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Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs

- Lakkakula, Jaya R, Kurapati, Rajendra, Tynga, Ivan, Krause, Rui W M, Abrahamse, Heidi, Raichur, Ashok M

Authors: Lakkakula, Jaya R , Kurapati, Rajendra , Tynga, Ivan , Krause, Rui W M , Abrahamse, Heidi , Raichur, Ashok M
Date: 2016
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/125435 , vital:35783 , https://doi.org/10.1039/C6RA12951J
Description: Porous CaCO3 microparticles have been used earlier for sustained drug release of hydrophilic drugs but have certain drawbacks for use with hydrophobic drugs. Hence, to overcome these drawbacks, a novel composite of CaCO3 along with cyclodextrin (CD–CaCO3) for the delivery of hydrophobic drugs was developed. Cyclodextrins (CDs), when incorporated within CaCO3, increased the porosity and surface area of microparticles thereby enhancing the encapsulation efficiency of hydrophobic drugs (5-Fluorouracil or Na-L-thyroxine) by forming inclusion complexes with cyclodextrin. Thermogravimetric and FTIR studies confirmed the interaction between the cyclodextrin and CaCO3 microparticles. Raman spectra confirmed the peak of vaterite crystals before and after loading of hydrophobic drugs within the composite. In vitro release studies when performed at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) showed release at low pH as CaCO3 is soluble at acidic pH unlike slower release at basic pH. Release kinetics followed a Higuchi kinetic model at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) respectively.
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Date Issued: 2016

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Facile deposition of gold nanoparticle thin films on semi-permeable cellulose substrate

- Sosibo, Ndabenhle, Mdluli, Phumlani, Mashazi, Philani N, Tshikhudo, Robert, Skepu, Amanda, Vilakazi, Sibulelo, Nyokong, Tebello

Authors: Sosibo, Ndabenhle , Mdluli, Phumlani , Mashazi, Philani N , Tshikhudo, Robert , Skepu, Amanda , Vilakazi, Sibulelo , Nyokong, Tebello
Date: 2012
Subjects: To be catalogued
Language: English
Type: text , article
Identifier: http://hdl.handle.net/10962/242638 , vital:51063 , xlink:href="https://doi.org/10.1016/j.matlet.2012.08.043"
Description: This study reports the facile method for the deposition of gold nanoparticle thin film onto a monoporous semi-permeable cellulose membrane through the diffusion of borohydride ions leading to the reduction of AuCl4− ions. The synthesis of gold nanoparticle thin film was deposited on one side of the membrane that was exposed to AuCl4− ions while the other side containing a reducing agent remained clear. The gold nanoparticle thin film exhibited a broad surface plasmon resonance (SPR) peak at 529 nm. Various characterization techniques were employed and all demonstrated the presence of gold thin film. The reported method represents a simplistic method for the deposition of gold nanoparticle thin films and various other metal nanoparticles may be deposited following this method.
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Date Issued: 2012

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A critical analysis of the examining of poetry in the English First Language Higher Grade course at senior secondary level in Cape Education Department schools

- Clarke, Linda Colleen

Authors: Clarke, Linda Colleen
Date: 1993
Subjects: Examinations -- South Africa -- Evaluation English poetry -- Examinations English poetry -- Study and teaching (Secondary -- South Africa
Language: English
Type: Thesis , Masters , MEd
Identifier: vital:1473 , http://hdl.handle.net/10962/d1003354
Description: The study of poetry has become entrenched in most secondary school English syllabuses, including the English First Language Higher Grade syllabus of the Cape Education Department. This acceptance of poetry as a part of the formal academic programme has, however, been accompanied by a demand that could be considered contrary to the spirit of poetry: that an examination should conclude the study. The problem is exacerbated if this examination is set and controlled by an external body, since the nature and objectives of a standardised, mass examination frequently conflict sharply with the aims of studying poetry. The implications of such control over the examining of poetry go beyond this, however. These include the defining and narrowing of the course of study by means of lists of prescribed poems selected by a committee often far removed from the world of the candidates and the significant combined effect of these lists and the style of questioning adopted by the external examiners on methods of teaching. Furthermore, the influence of the external examination is not restricted to the final year of study; the approach to poetry during the entire senior secondary course (of three years) tends to conform to the pattern laid down by the final examination paper. This domination of the external examination over the study of poetry is acknowledged but not condoned. There is undoubtedly a need for further research into alternative ways of assessing a poetry course. In the face of reality, however, this study seeks to identify and analyse the many features of external control that influence the study of poetry; and to consider ways in which examinations in poetry can be devised, approached and used to the best effect in order to fulfil the aims of studying poetry. The most important of these aims are held to be the pleasure and enjoyment of personal engagement with a poem, where there is a meeting of minds, a generation and deepening of emotion and feeling, extension of awareness and stimulation of imagination.
Full Text: false
Date Issued: 1993

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Bantwana

- Monwabisi Gladstone Sabani, Tracey, Andrew T N

Authors: Monwabisi Gladstone Sabani , Tracey, Andrew T N
Date: 1987
Subjects: Xhosa (African people) -- Music , Folk music -- South Africa , Topical songs , Guitar , Sub-Saharan African music , Africa South Africa Grahamstown f-za
Language: Xhosa
Type: sound recordings , field recordings , sound recording-musical
Identifier: http://hdl.handle.net/10962/99021 , vital:31654 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC078a-08
Description: Topical Xhosa urban song with guitar accompaniment
Full Text: false
Date Issued: 1987

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"Get organised": a practical student manual

- Western Cape Youth League

Authors: Western Cape Youth League
Date: 1985-10
Subjects: Youth -- Political activity -- Western Cape (South Africa) , Students -- Political activity -- Western Cape (South Africa) , Apartheid -- South Africa , Student government -- South Africa
Language: English
Type: text , book
Identifier: http://hdl.handle.net/10962/76262 , vital:30528
Description: The past few months have seen our courageous youth take to the streets to demonstrate their disgust against this system of exploitation and oppression. This militant fervour has touched many young hearts and minds. However, there is always the danger that these energies will burn out and dissipate. Demoralisation can so easily set in if these energies are not constructively channeled. "Channeled into what?” you may ask. ORGANISATIONS. It is only through strong organisations which attempt to give guidance and direction that meaningful action can be undertaken. The WCYL recognises the important need for students to begin to discuss broader issues such as The History of Struggle in S.A. or The Nature of S.A. Society. It is only when students begin to grapple with broader issues such as these, together with more specific ones, in a co-ordinated manner, will their actions be more effective. To this end has "GET ORGANISED" been designed. The handbook is intended as a guide for students in their efforts to organise SRC’s, awareness programmes, among other things, in schools.
Full Text: false
Date Issued: 1985-10

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A critical investigation into the methods of determining sulphur in plant material

- Smith, Anthony John Hibbert

Authors: Smith, Anthony John Hibbert
Date: 1962
Subjects: Plants -- Effect of sulfur on , Plants -- Nutrition , Sulfur
Language: English
Type: Thesis , Masters , MSc
Identifier: vital:4520 , http://hdl.handle.net/10962/d1014526
Description: Although sulphur is one of the more abundant elements present in plants, its importance as a plant nutrient has been underestimated until comparatively recently. Scientific literature over the past few years, however, shows that interest in the determination of sulphur in natural waters, soil and plant materials has been renewed. Perhaps the main reason for the non-recognition of the importance of sulphur as a plant nutrient is the fact that sulphur-deficiency seldom occurs since sufficient sulphur is usually added to the soil in rainfall (particularly near industrial towns) to supply all the sulphur requirements of plants. In addition, sulphur is frequently present in fertilizers added to soils to counteract deficiency in other elements, especially phosphorus. Superphosphates, for example contain up to 60%, gypsum. Sulphur is also added to the soil in some instances in order to reduce the soil pH, the elemental sulphur being fairly readily oxidised in the soil to sulphuric acid. The organic fraction in the soil also contains sulphur. , [From Introduction]. Although sulphur is one of the more abundant elements present in plants, its importance as a plant nutrient has been underestimated until comparatively recently. Scientific literature over the past few years, however, shows that interest in the determination of sulphur in natural waters, soil and plant materials has been renewed. Perhaps the main reason for the non-recognition of the importance of sulphur as a plant nutrient is the fact that sulphur-deficiency seldom occurs since sufficient sulphur is usually added to the soil in rainfall (particularly near industrial towns) to supply all the sulphur requirements of plants. In addition, sulphur is frequently present in fertilizers added to soils to counteract deficiency in other elements, especially phosphorus. Superphosphates, for example contain up to 60%, gypsum. Sulphur is also added to the soil in some instances in order to reduce the soil pH, the elemental sulphur being fairly readily oxidised in the soil to sulphuric acid. The organic fraction in the soil also contains sulphur.
Full Text: false
Date Issued: 1962

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Grahamstown : a preliminary delineation of ecological zones in the city

- Watts, Hilstan Lett, 1929-

Authors: Watts, Hilstan Lett, 1929-
Date: 1957
Subjects: f-sa , 2 cm = 2000 yards 30.5595° S, 22.9375° E , Grahamstown (South Africa) Maps , Grahamstown (South Africa) Street maps , South Africa History 1909-1961 , South Africa History 1836-1909
Language: English
Type: maps , digital maps , cartographic
Identifier: http://hdl.handle.net/10962/120796 , vital:34932 , Cory Library for Humanities Research, Rhodes University Library, Grahamstown, South Africa , T654_12
Description: Map 12 in the map album accompanying the thesis by Hilstan Lett Watts, "Grahamstown : a socio-ecological study of a small South African town", Rhodes University thesis, 1957. Map signed 1955. The data are from the sample survey of the European area of Grahamstown.
Full Text: false
Date Issued: 1957

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