Innovation through education: rediscovering the lost generation
- Authors: Pieterse, Koot
- Subjects: Business incubators , Entrepreneurship , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/20889 , vital:29411
- Description: Innovation implies the generation as well as the practical implementation of new ideas. These ideas could appear as new product opportunities, new markets or new management systems and business schools are ideally situated to promote their exploitation and implementation. This study emphasises the need for business schools to elevate innovation to one of the core values in their mission. The need for innovation in the local business environment is explored along with reasons why these opportunities have not always been pursued with the required vigour. The results of a literature study are represented, that demonstrate what initiatives on the incorporation of innovation into their activities have been taken by a selection of business schools around the world and the study is concluded by exploring similar opportunities open to the Business School of the Nelson Mandela Metropolitan University.
- Full Text:
- Authors: Pieterse, Koot
- Subjects: Business incubators , Entrepreneurship , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/20889 , vital:29411
- Description: Innovation implies the generation as well as the practical implementation of new ideas. These ideas could appear as new product opportunities, new markets or new management systems and business schools are ideally situated to promote their exploitation and implementation. This study emphasises the need for business schools to elevate innovation to one of the core values in their mission. The need for innovation in the local business environment is explored along with reasons why these opportunities have not always been pursued with the required vigour. The results of a literature study are represented, that demonstrate what initiatives on the incorporation of innovation into their activities have been taken by a selection of business schools around the world and the study is concluded by exploring similar opportunities open to the Business School of the Nelson Mandela Metropolitan University.
- Full Text:
Cyclic voltammetry and spectroelectrochemistry of a novel manganese phthalocyanine substituted with hexynyl groups
- Quinton, Damien, Antunes, Edith M, Griveau, Sophie, Nyokong, Tebello, Bedioui, Fethi
- Authors: Quinton, Damien , Antunes, Edith M , Griveau, Sophie , Nyokong, Tebello , Bedioui, Fethi
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/248450 , vital:51687 , xlink:href="https://doi.org/10.1016/j.inoche.2010.11.029"
- Description: We report here on the synthesis of a new manganese phthalocyanine complex, namely Mn tetrakis(5-hexyn-oxy) phthalocyanine (3), specifically designed to possess an alkyne moiety for its potential use in controlled immobilization on electrodes via the so called “click” chemistry reaction. The electrochemical activity of complex 3 was investigated by cyclic voltammetry and the nature of the observed redox couples was elucidated by spectroelectrochemistry. This work has also shown that the reduction of Mn(III)Pc complex to Mn(II)Pc is accompanied by the formation of MnPc μ-oxo species. Further reduction results in the formation of Mn(II)Pc(− 3) rather than Mn(I)Pc(− 2).
- Full Text:
- Date Issued: 2011
- Authors: Quinton, Damien , Antunes, Edith M , Griveau, Sophie , Nyokong, Tebello , Bedioui, Fethi
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/248450 , vital:51687 , xlink:href="https://doi.org/10.1016/j.inoche.2010.11.029"
- Description: We report here on the synthesis of a new manganese phthalocyanine complex, namely Mn tetrakis(5-hexyn-oxy) phthalocyanine (3), specifically designed to possess an alkyne moiety for its potential use in controlled immobilization on electrodes via the so called “click” chemistry reaction. The electrochemical activity of complex 3 was investigated by cyclic voltammetry and the nature of the observed redox couples was elucidated by spectroelectrochemistry. This work has also shown that the reduction of Mn(III)Pc complex to Mn(II)Pc is accompanied by the formation of MnPc μ-oxo species. Further reduction results in the formation of Mn(II)Pc(− 3) rather than Mn(I)Pc(− 2).
- Full Text:
- Date Issued: 2011
Rhodes University Graduation Ceremony 2011
- Authors: Rhodes University
- Date: 2011
- Language: English
- Type: text
- Identifier: vital:8136 , http://hdl.handle.net/10962/d1007246
- Description: Rhodes University Graduation Ceremonies [at] 1820 Settlers National Monument Thursday, 7 April at 18.00 [and] Friday, 8 April at 10:30; 14:30 & 18:00 [and] Saturday, 9 April at 10:30
- Full Text:
- Date Issued: 2011
- Authors: Rhodes University
- Date: 2011
- Language: English
- Type: text
- Identifier: vital:8136 , http://hdl.handle.net/10962/d1007246
- Description: Rhodes University Graduation Ceremonies [at] 1820 Settlers National Monument Thursday, 7 April at 18.00 [and] Friday, 8 April at 10:30; 14:30 & 18:00 [and] Saturday, 9 April at 10:30
- Full Text:
- Date Issued: 2011
SADSAWU submission to the portfolio committee on labour
- SADSAWU
- Authors: SADSAWU
- Date: 2011
- Subjects: SADSAWU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/173910 , vital:42421
- Description: DOMESTIC WORK IS WORK; DOMESTIC WORKERS ARE WORKERS; SADSAWU through our active involvement in the processes leading up to the adoption of the ILO convention on domestic workers, recognises that our country has made huge strides to protect domestic workers in relation to other countries. South Africa and particularly the Department of Labour played a leading role ensuring that the ILO adopted the convention on the 16th June 2011. Our right to organise, to a contract of employment, to participate in processes of setting national minimum wages and conditions of employment has been achieved long before the adoption of the ILO convention But we have to continue to lead and the nexi step is the ratification of the ILO convention on domestic workers by the South African government - let us be the first country to do so in Africa and in the world.
- Full Text:
- Date Issued: 2011
- Authors: SADSAWU
- Date: 2011
- Subjects: SADSAWU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/173910 , vital:42421
- Description: DOMESTIC WORK IS WORK; DOMESTIC WORKERS ARE WORKERS; SADSAWU through our active involvement in the processes leading up to the adoption of the ILO convention on domestic workers, recognises that our country has made huge strides to protect domestic workers in relation to other countries. South Africa and particularly the Department of Labour played a leading role ensuring that the ILO adopted the convention on the 16th June 2011. Our right to organise, to a contract of employment, to participate in processes of setting national minimum wages and conditions of employment has been achieved long before the adoption of the ILO convention But we have to continue to lead and the nexi step is the ratification of the ILO convention on domestic workers by the South African government - let us be the first country to do so in Africa and in the world.
- Full Text:
- Date Issued: 2011
Temperature activated ionic conductivity in gallium and indium phthalocyanines
- San, Sait Eren, Okutan, Mustafa, Nyokong, Tebello, Durmus, Mahmut, Ozturk, Birol
- Authors: San, Sait Eren , Okutan, Mustafa , Nyokong, Tebello , Durmus, Mahmut , Ozturk, Birol
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247686 , vital:51607 , xlink:href="https://doi.org/10.1016/j.poly.2010.12.047"
- Description: The effects of introducing gallium and indium metals into phthalocyanine molecules were investigated via temperature and frequency dependent dielectric spectroscopy. The dielectric properties of Ga(III) and In(III) phthalocyanine pellets were measured at frequencies from 1 kHz to 1 MHz in the temperature range 300–530 K. The temperature dependence of the real part of the dielectric constant suggested that these compounds exhibit semiconductor behavior. The activation energy values were calculated from the Arrhenius plots at different frequencies. A distinct transition in these plots indicated the activation of ionic conductivity at higher temperatures.
- Full Text:
- Date Issued: 2011
- Authors: San, Sait Eren , Okutan, Mustafa , Nyokong, Tebello , Durmus, Mahmut , Ozturk, Birol
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247686 , vital:51607 , xlink:href="https://doi.org/10.1016/j.poly.2010.12.047"
- Description: The effects of introducing gallium and indium metals into phthalocyanine molecules were investigated via temperature and frequency dependent dielectric spectroscopy. The dielectric properties of Ga(III) and In(III) phthalocyanine pellets were measured at frequencies from 1 kHz to 1 MHz in the temperature range 300–530 K. The temperature dependence of the real part of the dielectric constant suggested that these compounds exhibit semiconductor behavior. The activation energy values were calculated from the Arrhenius plots at different frequencies. A distinct transition in these plots indicated the activation of ionic conductivity at higher temperatures.
- Full Text:
- Date Issued: 2011
The next decade of environmental science in South Africa: a horizon scan
- Shackleton, Charlie M, Scholes, Robert J, Vogel, Coleen, Wynberg, Rachel, Abrahamse, Tanya, Shackleton, Sheona E, Ellery, William F N, Gambiza, James
- Authors: Shackleton, Charlie M , Scholes, Robert J , Vogel, Coleen , Wynberg, Rachel , Abrahamse, Tanya , Shackleton, Sheona E , Ellery, William F N , Gambiza, James
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157124 , vital:40088 , https://doi.org/10.1080/03736245.2011.563064
- Description: Environmental systems are in constant flux, with feedbacks and non-linearities catalysed by natural trends and shocks as well as human actions. This poses challenges for sustainable management to promote human well-being. It requires environmental understanding and application that can accommodate such fluxes and pressures, as well as knowledge production systems and institutions that produce graduates with appropriate skills. In this article we consider these challenges in the South African context. Firstly, we summarise six significant environmental realisations from the last decade of environmental science internationally and question what they mean for the teaching of environmental science and research into environmental systems in South Africa in the near future. We then consider these lessons within the context of a horizon scan of near-term pressing environmental issues in South Africa. These include wateruse efficiency, poverty, food security, inequities in land and resource access, urbanisation, agrochemicals and water quality, promoting human well-being and economic adaptability in the face of climate change, and imbuing stronger environmental elements and stewardship into the integrated development planning processes and outcomes. Lastly, we consider the knowledge areas and skills that environmental graduates will require to be able to confront these problems in South Africa and simultaneously contribute to international debates and understandings around the complexity of environmental systems and how to manage them.
- Full Text:
- Date Issued: 2011
- Authors: Shackleton, Charlie M , Scholes, Robert J , Vogel, Coleen , Wynberg, Rachel , Abrahamse, Tanya , Shackleton, Sheona E , Ellery, William F N , Gambiza, James
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157124 , vital:40088 , https://doi.org/10.1080/03736245.2011.563064
- Description: Environmental systems are in constant flux, with feedbacks and non-linearities catalysed by natural trends and shocks as well as human actions. This poses challenges for sustainable management to promote human well-being. It requires environmental understanding and application that can accommodate such fluxes and pressures, as well as knowledge production systems and institutions that produce graduates with appropriate skills. In this article we consider these challenges in the South African context. Firstly, we summarise six significant environmental realisations from the last decade of environmental science internationally and question what they mean for the teaching of environmental science and research into environmental systems in South Africa in the near future. We then consider these lessons within the context of a horizon scan of near-term pressing environmental issues in South Africa. These include wateruse efficiency, poverty, food security, inequities in land and resource access, urbanisation, agrochemicals and water quality, promoting human well-being and economic adaptability in the face of climate change, and imbuing stronger environmental elements and stewardship into the integrated development planning processes and outcomes. Lastly, we consider the knowledge areas and skills that environmental graduates will require to be able to confront these problems in South Africa and simultaneously contribute to international debates and understandings around the complexity of environmental systems and how to manage them.
- Full Text:
- Date Issued: 2011
Evaluation of the kinetics and mechanism of drug release from Econazole nitrate nanosponge loaded Carbapol Hydrogel
- Sharma, Renuka, Walker, Roderick B, Pathak, Kamla
- Authors: Sharma, Renuka , Walker, Roderick B , Pathak, Kamla
- Date: 2011
- Language: English
- Type: text , Article
- Identifier: vital:6437 , http://hdl.handle.net/10962/d1006614
- Description: The objective of this study was to investigate the mechanism of release of econazole nitrate (EN) nanosponges loaded hydrogel and to compare it with EN hydrogel so as to develop an extended release topical drug delivery system of EN. Nanosponges of EN were prepared using ethyl cellulose and PVA by emulsion solvent evaporation method. On the basis of pharmacotechnical evaluation nanosponges with least particle size of 230.1 nm and good rheological properties were formulated as hydrogel (F1 – F7). In vitro drug release data of EN nanosponges loaded hydrogels in phosphate buffer pH 6.8 and 7.4 when analysed by GraphPad Prism software version 4.0 San Diego, USA best fitted the Makoid-2 Banakar model (R value greater than 0.98). The Korsmeyer-Peppas release exponent (n) ranged between 0.331 – 0.418, which confirmed diffusion as the principle mechanism of drug release. The release mechanism was further confirmed by calculating the ratio of exponents A/B ratio derived from the Kopcha model.
- Full Text:
- Date Issued: 2011
- Authors: Sharma, Renuka , Walker, Roderick B , Pathak, Kamla
- Date: 2011
- Language: English
- Type: text , Article
- Identifier: vital:6437 , http://hdl.handle.net/10962/d1006614
- Description: The objective of this study was to investigate the mechanism of release of econazole nitrate (EN) nanosponges loaded hydrogel and to compare it with EN hydrogel so as to develop an extended release topical drug delivery system of EN. Nanosponges of EN were prepared using ethyl cellulose and PVA by emulsion solvent evaporation method. On the basis of pharmacotechnical evaluation nanosponges with least particle size of 230.1 nm and good rheological properties were formulated as hydrogel (F1 – F7). In vitro drug release data of EN nanosponges loaded hydrogels in phosphate buffer pH 6.8 and 7.4 when analysed by GraphPad Prism software version 4.0 San Diego, USA best fitted the Makoid-2 Banakar model (R value greater than 0.98). The Korsmeyer-Peppas release exponent (n) ranged between 0.331 – 0.418, which confirmed diffusion as the principle mechanism of drug release. The release mechanism was further confirmed by calculating the ratio of exponents A/B ratio derived from the Kopcha model.
- Full Text:
- Date Issued: 2011
Hierarchical spatial organization and prioritization of wetlands: a conceptual model for wetland rehabilitation in South Africa
- Sieben, E J J, Ellery, William F N, Kotze, Donovan C, Rountree, M
- Authors: Sieben, E J J , Ellery, William F N , Kotze, Donovan C , Rountree, M
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144399 , vital:38342 , DOI: 10.1007/s11273-011-9212-8
- Description: Wetland rehabilitation planning needs to take into account many different aspects of the wetland and its context. In South Africa, much emphasis is placed on the delivery of ecosystem services, poverty relief and skills development for those involved in labour-intensive rehabilitation measures. A framework is presented that facilitates decision-making with regards to wetland rehabilitation planning. This starts with prioritizing which wetlands need attention within a catchment. This is followed by decisions regarding which rehabilitation measures would be effective in improving certain ecosystem services based upon the aims of rehabilitation and the social context of the surrounding catchment.
- Full Text:
- Date Issued: 2011
- Authors: Sieben, E J J , Ellery, William F N , Kotze, Donovan C , Rountree, M
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144399 , vital:38342 , DOI: 10.1007/s11273-011-9212-8
- Description: Wetland rehabilitation planning needs to take into account many different aspects of the wetland and its context. In South Africa, much emphasis is placed on the delivery of ecosystem services, poverty relief and skills development for those involved in labour-intensive rehabilitation measures. A framework is presented that facilitates decision-making with regards to wetland rehabilitation planning. This starts with prioritizing which wetlands need attention within a catchment. This is followed by decisions regarding which rehabilitation measures would be effective in improving certain ecosystem services based upon the aims of rehabilitation and the social context of the surrounding catchment.
- Full Text:
- Date Issued: 2011
LTSP DNS round robin clusters: green technology access enablers for telecommunication services in marginalised communities
- Siebörger, Ingrid, Terzoli, Alfredo, Hodgkinson-Williams, Cheryl
- Authors: Siebörger, Ingrid , Terzoli, Alfredo , Hodgkinson-Williams, Cheryl
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428437 , vital:72511 , https://d1wqtxts1xzle7.cloudfront.net/75984640/177-libre.pdf?1639074275=andresponse-content-disposi-tion=inline%3B+filename%3DLTSP_DNS_Round_Robin_Clusters_Green_Tech.pdfandExpires=1714912779andSignature=Gmd52OTCvGmiKhiFiQH~rrfp6lSPbp7glndLPn7V4Jy5yt7lU-eToE4IPxr7lDQQOdUW348nkXIMgYHnXkWjWl7nYBM7hlluxJGd15oKbpifvTofHVVEB-kOLbz0caOrAodnS~eMHdebRQOumKSAHPGQkqem756vbw0KV7bhmFQ0TUN-vsVeBoH5ftfg7s355Oh9EZCQhZu~~P0AWzlSRnMTH~6vpj3EKvp7P4gy55oISZ~207VFFFZidb90aoP7JWehRYjRqn3Tk19A6nwm4o9U-wc9Dz1MrCy-YfbqOxdNulQh4bti2WI7DA6C3Q8TMCbtqnZskXQYsIzfEianS~gw__andKey-Pair-Id=APKAJLOHF5GGSLRBV4ZA
- Description: Rural development is seen as a priority in South Africa; information and knowledge are key strategic resources for social and economic develop-ment. Information Communication Technologies (ICTs) are seen as im-portant tools in rural development, assisting in enabling change through economic development. In rural areas where ICT infrastructure is being expanded and deployed there is a need to provide appropriate technolo-gies that support sustainability and meet the needs of the local communi-ty. In this paper we argue that the use of Linux Terminal Server Project (LTSP) cluster servers are appropriate technologies for use in computer laboratory environments for relatively inexpensive access to technologies by schools and local communities in rural areas. Typically LTSP clusters are deployed when there is a need to support 100s or 1000s of comput-ers, however, we argue that by reusing recycled (older) desktop or server computers as cluster servers could lower the entry level costs of LTSP computing while maximising the use of available resources. The paper details the configuration of a Domain Name System (DNS) round robin cluster solution together with initial testing and results. It is suggested that LTSP cluster solutions, and the DNS round robin implementation, show promise for use in providing access technologies to rural communities and schools.
- Full Text:
- Date Issued: 2011
- Authors: Siebörger, Ingrid , Terzoli, Alfredo , Hodgkinson-Williams, Cheryl
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428437 , vital:72511 , https://d1wqtxts1xzle7.cloudfront.net/75984640/177-libre.pdf?1639074275=andresponse-content-disposi-tion=inline%3B+filename%3DLTSP_DNS_Round_Robin_Clusters_Green_Tech.pdfandExpires=1714912779andSignature=Gmd52OTCvGmiKhiFiQH~rrfp6lSPbp7glndLPn7V4Jy5yt7lU-eToE4IPxr7lDQQOdUW348nkXIMgYHnXkWjWl7nYBM7hlluxJGd15oKbpifvTofHVVEB-kOLbz0caOrAodnS~eMHdebRQOumKSAHPGQkqem756vbw0KV7bhmFQ0TUN-vsVeBoH5ftfg7s355Oh9EZCQhZu~~P0AWzlSRnMTH~6vpj3EKvp7P4gy55oISZ~207VFFFZidb90aoP7JWehRYjRqn3Tk19A6nwm4o9U-wc9Dz1MrCy-YfbqOxdNulQh4bti2WI7DA6C3Q8TMCbtqnZskXQYsIzfEianS~gw__andKey-Pair-Id=APKAJLOHF5GGSLRBV4ZA
- Description: Rural development is seen as a priority in South Africa; information and knowledge are key strategic resources for social and economic develop-ment. Information Communication Technologies (ICTs) are seen as im-portant tools in rural development, assisting in enabling change through economic development. In rural areas where ICT infrastructure is being expanded and deployed there is a need to provide appropriate technolo-gies that support sustainability and meet the needs of the local communi-ty. In this paper we argue that the use of Linux Terminal Server Project (LTSP) cluster servers are appropriate technologies for use in computer laboratory environments for relatively inexpensive access to technologies by schools and local communities in rural areas. Typically LTSP clusters are deployed when there is a need to support 100s or 1000s of comput-ers, however, we argue that by reusing recycled (older) desktop or server computers as cluster servers could lower the entry level costs of LTSP computing while maximising the use of available resources. The paper details the configuration of a Domain Name System (DNS) round robin cluster solution together with initial testing and results. It is suggested that LTSP cluster solutions, and the DNS round robin implementation, show promise for use in providing access technologies to rural communities and schools.
- Full Text:
- Date Issued: 2011
A Critical Analysis of the Role of School Governing Bodies in the Recruitment, Selection and Transfer of Educators in the Butterworth District
- Authors: Sifuba, Mpilo
- Date: 2011
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/3495 , vital:43616
- Description: Recruitment, selection and transfer of educators were decentralized after South Africa became a democratic state in 1994 and shifted to School Governing Bodies. The legislation promoted a shared governance and participation of parents in issues that are related to recruitment, selection and transfer of educators, but parents are struggling and facing challenges in performing these tasks as School Governing Body members especially in the Butterworth district, as a result of that Butterworth district is experiencing problems with increasing number of disputes resulting from the appointment of educators after they have been recommended by the School Governing Bodies. This study focuses on the recruitment, selection and transfer of educators in the Butterworth district of the Eastern Cape Province of South Africa. The study sought to reveal the thinking behind government insistence on giving the School Governing Bodies a responsibility to recruit, select and transfer educators knowing fully well that they do not perform this responsibility. A qualitative approach was used to explore and challenge this phenomenon. This approach is concerned with understanding social phenomenon from the participant’s perspective. In depth semi – structured interviews with open ended questions were used to bring the researcher more closer to a more plausible perspective of this phenomenon. Moreover, they were used because they are the most appropriate method to capture the data. The findings revealed that School Governing Bodies are faced with challenges such as: high level of illiteracy, manipulation of School Governing Bodies by school management, unions and candidates, the issue of regionalism and kickbacks, capacity building and empowerment and role played by the Departmental Officials. By conducting this study, we hope that the findings might contribute in identifying the disjuncture between the policy and the practice in issues pertaining to educator recruitment, selection and transfers. , Thesis (MMED) -- Faculty of Educational Sciences, 2011
- Full Text:
- Date Issued: 2011
- Authors: Sifuba, Mpilo
- Date: 2011
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/3495 , vital:43616
- Description: Recruitment, selection and transfer of educators were decentralized after South Africa became a democratic state in 1994 and shifted to School Governing Bodies. The legislation promoted a shared governance and participation of parents in issues that are related to recruitment, selection and transfer of educators, but parents are struggling and facing challenges in performing these tasks as School Governing Body members especially in the Butterworth district, as a result of that Butterworth district is experiencing problems with increasing number of disputes resulting from the appointment of educators after they have been recommended by the School Governing Bodies. This study focuses on the recruitment, selection and transfer of educators in the Butterworth district of the Eastern Cape Province of South Africa. The study sought to reveal the thinking behind government insistence on giving the School Governing Bodies a responsibility to recruit, select and transfer educators knowing fully well that they do not perform this responsibility. A qualitative approach was used to explore and challenge this phenomenon. This approach is concerned with understanding social phenomenon from the participant’s perspective. In depth semi – structured interviews with open ended questions were used to bring the researcher more closer to a more plausible perspective of this phenomenon. Moreover, they were used because they are the most appropriate method to capture the data. The findings revealed that School Governing Bodies are faced with challenges such as: high level of illiteracy, manipulation of School Governing Bodies by school management, unions and candidates, the issue of regionalism and kickbacks, capacity building and empowerment and role played by the Departmental Officials. By conducting this study, we hope that the findings might contribute in identifying the disjuncture between the policy and the practice in issues pertaining to educator recruitment, selection and transfers. , Thesis (MMED) -- Faculty of Educational Sciences, 2011
- Full Text:
- Date Issued: 2011
An investigation into the demand for money in South Africa during the period (1990-2009)
- Simawu, Moreblessing https://orcid.org/0000-0003-4413-4660
- Authors: Simawu, Moreblessing https://orcid.org/0000-0003-4413-4660
- Date: 2011
- Subjects: Demand for money -- South Africa , Monetary policy -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24421 , vital:62789
- Description: A stable money demand function plays a vital role in the analysis of macroeconomics, especially in the planning and implementation of monetary policy. With the use of Johansen cointegration and error correction model estimates, this study examines the existence of a stable long-run relationship between real money demand (RM2 and RM3) and its explanatory variables, in South Africa, for the period 1990-2009. The explanatory variables used in this study are selected on the basis of different monetary theories and empirical works, including the Keynesian, Classical and Friedman’s modern quantity theory of money. Based on these theories, the explanatory variables used in this thesis are real income, an interest rate, the inflation rate ,the exchange rate and foreign interest rate. The signs of the coefficients of the variables are as expected from economic theory. The coefficients of real income, the exchange rate and foreign interest rate are positive, while the coefficients of the interest rate and inflation rate are negative. This study augments the cointegration and vector autoregression (VAR) analysis with impulse response and variance decomposition analyses to provide robust long run effects and short run dynamic effects on the real money demand. In addition a foreign interest rate to capture the impact of capital mobility on money demand in South Africa was used. Results from the Johansen test suggest that real money demand (RM2 and RM3) and its all explanatory variables are cointegrated. Hence, there is a long-run equilibrium relationship between the real quantity of money demanded and five broadly defined macroeconomic components namely, real income, an interest rate, the inflation rate, foreign interest rate and the exchange rate in South Africa. Overall, the study finds that the coefficients of the equilibrium error terms are negative, as expected, and significantly different from zero, implying that 0.16 and 0.1 of the discrepancy between money demand and its explanatory variables is eliminated in the following quarter. Application of CUSUM and CUSUMSQ stability test showed that real money demand (M2 and M3) is stable in South Africa. The impulse response analysis provided evidence that the real M3 money, national income, rate of inflation and the foreign interest rate have a significant impact on the real M3 money demand in the short run. However, remaining variables (the real exchange rate and prime overdraft rate), have only a transitory effect on the real M3 money demand. There was further evidence that real exchange rate, the rate of inflation and the foreign interest rate, have a significant impact on the real M2 money demand in the short run. However, remaining variables (the national income and prime overdraft rate), have only a transitory effect on the real M2 money demand. Results from the variance decompositions of the real money demand are basically similar to those from the impulse response analysis and reveal that the fundamentals explain some, but not all, of the variations of the real money demand. The results showed that the national income explains the largest component of the variation in the real M2 money demand followed by the exchange rate and foreign interest rate. Shocks to the other variables continued to explain an insignificant proportion of the variation in the real M2 money demand. The national income also explains the largest component of the variation in the real M3 money demand followed by the foreign interest rate and exchange rate. Shocks to the other variables continued to explain a less significant proportion of the variation in the real M3 money demand.The study finds that both real M2 and M3 are stable which makes monetary targeting a viable policy option for the SARB. , Thesis (MCom) -- Faculty of Management and Commerce, 2011
- Full Text:
- Date Issued: 2011
- Authors: Simawu, Moreblessing https://orcid.org/0000-0003-4413-4660
- Date: 2011
- Subjects: Demand for money -- South Africa , Monetary policy -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24421 , vital:62789
- Description: A stable money demand function plays a vital role in the analysis of macroeconomics, especially in the planning and implementation of monetary policy. With the use of Johansen cointegration and error correction model estimates, this study examines the existence of a stable long-run relationship between real money demand (RM2 and RM3) and its explanatory variables, in South Africa, for the period 1990-2009. The explanatory variables used in this study are selected on the basis of different monetary theories and empirical works, including the Keynesian, Classical and Friedman’s modern quantity theory of money. Based on these theories, the explanatory variables used in this thesis are real income, an interest rate, the inflation rate ,the exchange rate and foreign interest rate. The signs of the coefficients of the variables are as expected from economic theory. The coefficients of real income, the exchange rate and foreign interest rate are positive, while the coefficients of the interest rate and inflation rate are negative. This study augments the cointegration and vector autoregression (VAR) analysis with impulse response and variance decomposition analyses to provide robust long run effects and short run dynamic effects on the real money demand. In addition a foreign interest rate to capture the impact of capital mobility on money demand in South Africa was used. Results from the Johansen test suggest that real money demand (RM2 and RM3) and its all explanatory variables are cointegrated. Hence, there is a long-run equilibrium relationship between the real quantity of money demanded and five broadly defined macroeconomic components namely, real income, an interest rate, the inflation rate, foreign interest rate and the exchange rate in South Africa. Overall, the study finds that the coefficients of the equilibrium error terms are negative, as expected, and significantly different from zero, implying that 0.16 and 0.1 of the discrepancy between money demand and its explanatory variables is eliminated in the following quarter. Application of CUSUM and CUSUMSQ stability test showed that real money demand (M2 and M3) is stable in South Africa. The impulse response analysis provided evidence that the real M3 money, national income, rate of inflation and the foreign interest rate have a significant impact on the real M3 money demand in the short run. However, remaining variables (the real exchange rate and prime overdraft rate), have only a transitory effect on the real M3 money demand. There was further evidence that real exchange rate, the rate of inflation and the foreign interest rate, have a significant impact on the real M2 money demand in the short run. However, remaining variables (the national income and prime overdraft rate), have only a transitory effect on the real M2 money demand. Results from the variance decompositions of the real money demand are basically similar to those from the impulse response analysis and reveal that the fundamentals explain some, but not all, of the variations of the real money demand. The results showed that the national income explains the largest component of the variation in the real M2 money demand followed by the exchange rate and foreign interest rate. Shocks to the other variables continued to explain an insignificant proportion of the variation in the real M2 money demand. The national income also explains the largest component of the variation in the real M3 money demand followed by the foreign interest rate and exchange rate. Shocks to the other variables continued to explain a less significant proportion of the variation in the real M3 money demand.The study finds that both real M2 and M3 are stable which makes monetary targeting a viable policy option for the SARB. , Thesis (MCom) -- Faculty of Management and Commerce, 2011
- Full Text:
- Date Issued: 2011
The determinants of household savings in South Africa
- Simleit, C, Keeotn, Gavin, Botha, Ferdi
- Authors: Simleit, C , Keeotn, Gavin , Botha, Ferdi
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/396153 , vital:69154 , xlink:href="https://hdl.handle.net/10520/EJC21526"
- Description: In South Africa, substantial government dissaving as well as poor household savings performance has caused a decline in aggregate savings. Whilst government dissaving has been successfully reversed, household savings continue to fall. Low domestic savings have required South Africa to attract large, volatile portfolio capital inflows to fund a structural current account deficit. Repeated reversals of such inflows have constrained domestic growth and hence an understanding of the factors that have caused this decline in savings is essential in order to formulate policies supportive of sustained higher rates of economic growth. Within the context of the existing literature, this article examines the various determinants of household savings using a vector error-correction model (VECM). The results suggest that interest rates, a wealth effect and upturns in the business cycle all contribute to explaining the decline in household savings. The presence of a partial offset between household savings and government savings also has important implications for the effectiveness of using the fiscal position of the South African government to boost savings.
- Full Text:
- Date Issued: 2011
- Authors: Simleit, C , Keeotn, Gavin , Botha, Ferdi
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/396153 , vital:69154 , xlink:href="https://hdl.handle.net/10520/EJC21526"
- Description: In South Africa, substantial government dissaving as well as poor household savings performance has caused a decline in aggregate savings. Whilst government dissaving has been successfully reversed, household savings continue to fall. Low domestic savings have required South Africa to attract large, volatile portfolio capital inflows to fund a structural current account deficit. Repeated reversals of such inflows have constrained domestic growth and hence an understanding of the factors that have caused this decline in savings is essential in order to formulate policies supportive of sustained higher rates of economic growth. Within the context of the existing literature, this article examines the various determinants of household savings using a vector error-correction model (VECM). The results suggest that interest rates, a wealth effect and upturns in the business cycle all contribute to explaining the decline in household savings. The presence of a partial offset between household savings and government savings also has important implications for the effectiveness of using the fiscal position of the South African government to boost savings.
- Full Text:
- Date Issued: 2011
The reward preference/motivation paradox and implications for performance and education
- Authors: Snelgar, Robin
- Subjects: Employee motivation , Incentive (Psychology) , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/21897 , vital:29799
- Description: The focus on reward preference has emerged essentially as a result of the need to identify what really motivates productive behaviour within the workplace, despite the fact that other variables such as retention and attraction have also been taken into consideratin. Motivation has always been an issue of great interest to both reserachers as well as practitioners within the organizational setting, the intention being to find ways to improve performance and, more specifically, particular types of performance within the world of work. Ultimately, the issue has always been how to understand, predict, shape and control human behaviour.
- Full Text: false
- Authors: Snelgar, Robin
- Subjects: Employee motivation , Incentive (Psychology) , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/21897 , vital:29799
- Description: The focus on reward preference has emerged essentially as a result of the need to identify what really motivates productive behaviour within the workplace, despite the fact that other variables such as retention and attraction have also been taken into consideratin. Motivation has always been an issue of great interest to both reserachers as well as practitioners within the organizational setting, the intention being to find ways to improve performance and, more specifically, particular types of performance within the world of work. Ultimately, the issue has always been how to understand, predict, shape and control human behaviour.
- Full Text: false
The experiences of Fringe producers at the South African National Arts Festival: production, profits and non-market benefits
- Snowball, Jeanette D, Antrobus, Geoffrey G
- Authors: Snowball, Jeanette D , Antrobus, Geoffrey G
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/143123 , vital:38203 , DOI: 10.1080/10137548.2009.9687901
- Description: Unlike the performing arts generally, festivals and special events have been growing in popularity worldwide: since the 1980s there has been an explosion of the number of festival of all types, not just arts festivals, but folk festivals, harvest festivals, food festivals, family festivals, carnivals, literary festivals – the list is long. It is estimated that there are more than 300 festivals in the UK (British Federation of Festivals 2004), 1300 in Australia (Johnson et al 2005) and more than 5000 in the US (Blumenthal 2002).
- Full Text:
- Date Issued: 2011
- Authors: Snowball, Jeanette D , Antrobus, Geoffrey G
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/143123 , vital:38203 , DOI: 10.1080/10137548.2009.9687901
- Description: Unlike the performing arts generally, festivals and special events have been growing in popularity worldwide: since the 1980s there has been an explosion of the number of festival of all types, not just arts festivals, but folk festivals, harvest festivals, food festivals, family festivals, carnivals, literary festivals – the list is long. It is estimated that there are more than 300 festivals in the UK (British Federation of Festivals 2004), 1300 in Australia (Johnson et al 2005) and more than 5000 in the US (Blumenthal 2002).
- Full Text:
- Date Issued: 2011
A Framework for DNS Based Detection of Botnets at the ISP Level
- Stalmans, Etienne, Irwin, Barry V W
- Authors: Stalmans, Etienne , Irwin, Barry V W
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/427984 , vital:72478 , https://www.researchgate.net/profile/Barry-Ir-win/publication/327622932_A_Framework_for_DNS_Based_Detection_of_Botnets_at_the_ISP_Level/links/5b9a14e1458515310583fc19/A-Framework-for-DNS-Based-Detection-of-Botnets-at-the-ISP-Level.pdf
- Description: The rapid expansion of networks and increase in internet connected devices has lead to a large number of hosts susceptible to virus infec-tion. Infected hosts are controlled by attackers and form so called bot-nets. These botnets are used to steal data, mask malicious activity and perform distributed denial of service attacks. Traditional protection mechanisms rely on host based detection of viruses. These systems are failing due to the rapid increase in the number of vulnerable hosts and attacks that easily bypass detection mechanisms. This paper pro-poses moving protection from the individual hosts to the Internet Ser-vice Provider (ISP), allowing for the detection and prevention of botnet traffic. DNS traffic inspection allows for the development of a lightweight and accurate classifier that has little or no effect on network perfor-mance. By preventing botnet activity at the ISP level, it is hoped that the threat of botnets can largely be mitigated.
- Full Text:
- Date Issued: 2011
- Authors: Stalmans, Etienne , Irwin, Barry V W
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/427984 , vital:72478 , https://www.researchgate.net/profile/Barry-Ir-win/publication/327622932_A_Framework_for_DNS_Based_Detection_of_Botnets_at_the_ISP_Level/links/5b9a14e1458515310583fc19/A-Framework-for-DNS-Based-Detection-of-Botnets-at-the-ISP-Level.pdf
- Description: The rapid expansion of networks and increase in internet connected devices has lead to a large number of hosts susceptible to virus infec-tion. Infected hosts are controlled by attackers and form so called bot-nets. These botnets are used to steal data, mask malicious activity and perform distributed denial of service attacks. Traditional protection mechanisms rely on host based detection of viruses. These systems are failing due to the rapid increase in the number of vulnerable hosts and attacks that easily bypass detection mechanisms. This paper pro-poses moving protection from the individual hosts to the Internet Ser-vice Provider (ISP), allowing for the detection and prevention of botnet traffic. DNS traffic inspection allows for the development of a lightweight and accurate classifier that has little or no effect on network perfor-mance. By preventing botnet activity at the ISP level, it is hoped that the threat of botnets can largely be mitigated.
- Full Text:
- Date Issued: 2011
An investigation into international transfer pricing guidelines and the anomalies arising from business restructurings by multi-national enterprises
- Authors: Stelloh, Marcus Matthias
- Date: 2011
- Language: English
- Type: text , Thesis , Masters , MCom
- Identifier: vital:879 , http://hdl.handle.net/10962/d1001633
- Description: The number of multinational enterprises has increased substantially. In part due to the integration of national economies (the European Union), improvements in communication and technology and the opportunity to reduce costs as a result of globalisation. Transfer pricing and especially business restructuring within multinationals is a fairly new concept.Professional legal and audit firms have different views on how to approach business restructurings. This research analyses important transfer pricing aspects and the anomalies that arise through business restructurings. The research method used in this research paper is primarily qualitative, comprising the analysis of various documentary sources of data. Relevant South African and international case law, tax legislation, the OECD Transfer Pricing Guidelines for Multinational Enterprises and Tax Administrations, the Transfer Pricing Aspects of Business Restructurings Discussion Draft and other reports were consulted and analysed. Further the views of recognised legal and tax experts that have been published in technical journals and text books were also considered and examined. A hypothetical example of a business restructuring transaction was constructed in order to illustrate practical issues and different approaches to solving them. The research has argued that the arm’s length principle, which forms the bases of transfer pricing regulation, is not an exact science but theoretically it is the most suitable measure.It may not be able to incorporate all variables, such as the cost savings through synergies of multinational enterprises, but it promotes international trade and investment by ensuring that transactions are based on fair prices. Business restructurings create anomalies in applying the arm’s length principle but these anomalies can be dealt with within the regulatory structure. The business restructuring approach recommended is realistic and pragmatic, but more clarity may be needed in certain circumstances. The research has also discussed the avoidance of transfer pricing audits, including having appropriate transfer pricing policies and documentation.
- Full Text:
- Date Issued: 2011
- Authors: Stelloh, Marcus Matthias
- Date: 2011
- Language: English
- Type: text , Thesis , Masters , MCom
- Identifier: vital:879 , http://hdl.handle.net/10962/d1001633
- Description: The number of multinational enterprises has increased substantially. In part due to the integration of national economies (the European Union), improvements in communication and technology and the opportunity to reduce costs as a result of globalisation. Transfer pricing and especially business restructuring within multinationals is a fairly new concept.Professional legal and audit firms have different views on how to approach business restructurings. This research analyses important transfer pricing aspects and the anomalies that arise through business restructurings. The research method used in this research paper is primarily qualitative, comprising the analysis of various documentary sources of data. Relevant South African and international case law, tax legislation, the OECD Transfer Pricing Guidelines for Multinational Enterprises and Tax Administrations, the Transfer Pricing Aspects of Business Restructurings Discussion Draft and other reports were consulted and analysed. Further the views of recognised legal and tax experts that have been published in technical journals and text books were also considered and examined. A hypothetical example of a business restructuring transaction was constructed in order to illustrate practical issues and different approaches to solving them. The research has argued that the arm’s length principle, which forms the bases of transfer pricing regulation, is not an exact science but theoretically it is the most suitable measure.It may not be able to incorporate all variables, such as the cost savings through synergies of multinational enterprises, but it promotes international trade and investment by ensuring that transactions are based on fair prices. Business restructurings create anomalies in applying the arm’s length principle but these anomalies can be dealt with within the regulatory structure. The business restructuring approach recommended is realistic and pragmatic, but more clarity may be needed in certain circumstances. The research has also discussed the avoidance of transfer pricing audits, including having appropriate transfer pricing policies and documentation.
- Full Text:
- Date Issued: 2011
Human DNAJ in cancer and stem cells:
- Sterrenberg, Jason N, Edkins, Adrienne L, Blatch, Gregory L
- Authors: Sterrenberg, Jason N , Edkins, Adrienne L , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165118 , vital:41210 , DOI: 10.1016/j.canlet.2011.08.019
- Description: The heat shock protein 40 kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions that may be independent of either of these chaperones. The DNAJ proteins are differentially expressed in human tissues and demonstrate the capacity to function to both promote and suppress cancer development by acting as chaperones for tumour suppressors or oncoproteins. We review the current literature on the function and expression of DNAJ in cancer, stem cells and cancer stem cells. Combining data from gene expression, proteomics and studies in other systems, we propose that DNAJ will be key regulators of cancer, stem cell and possibly cancer stem cell function. The diversity of DNAJ and their assorted roles in a range of biological functions means that selected DNAJ, provided there is limited redundancy and that a specific link to malignancy can be established, may yet provide an attractive target for specific and selective drug design for the development of anti-cancer treatments.
- Full Text:
- Date Issued: 2011
- Authors: Sterrenberg, Jason N , Edkins, Adrienne L , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165118 , vital:41210 , DOI: 10.1016/j.canlet.2011.08.019
- Description: The heat shock protein 40 kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions that may be independent of either of these chaperones. The DNAJ proteins are differentially expressed in human tissues and demonstrate the capacity to function to both promote and suppress cancer development by acting as chaperones for tumour suppressors or oncoproteins. We review the current literature on the function and expression of DNAJ in cancer, stem cells and cancer stem cells. Combining data from gene expression, proteomics and studies in other systems, we propose that DNAJ will be key regulators of cancer, stem cell and possibly cancer stem cell function. The diversity of DNAJ and their assorted roles in a range of biological functions means that selected DNAJ, provided there is limited redundancy and that a specific link to malignancy can be established, may yet provide an attractive target for specific and selective drug design for the development of anti-cancer treatments.
- Full Text:
- Date Issued: 2011
Relationship marketing in retail banks: superannuated concept?
- Authors: Tait, Madele
- Subjects: Relationship marketing , Banks and banking , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/20923 , vital:29418
- Description: All business is based on relationships. The firm only has to make them meaningful for its customers – provided that the customers want this (Grönroos 1994). Relationship marketing concerns the facilitation and managing of the relationships between the business and its customers and was developed as a response to the realisation that businesses were spending vast resources in time and money to attract new customers but very little on retaining existing ones. Relationship marketing is particularly relevant when a customer has alternative service providers to choose from, when the customer makes the selection decision and when there is an ongoing desire or need for a product or service, such as in the banking industry (Morgan & Hunt 1999).
- Full Text:
- Authors: Tait, Madele
- Subjects: Relationship marketing , Banks and banking , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/20923 , vital:29418
- Description: All business is based on relationships. The firm only has to make them meaningful for its customers – provided that the customers want this (Grönroos 1994). Relationship marketing concerns the facilitation and managing of the relationships between the business and its customers and was developed as a response to the realisation that businesses were spending vast resources in time and money to attract new customers but very little on retaining existing ones. Relationship marketing is particularly relevant when a customer has alternative service providers to choose from, when the customer makes the selection decision and when there is an ongoing desire or need for a product or service, such as in the banking industry (Morgan & Hunt 1999).
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Biphenyl sorption to different soil clay minerals
- Tandlich, Roman, Baláž, Štefan
- Authors: Tandlich, Roman , Baláž, Štefan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76869 , vital:30632 , https://doi.org/10.5897/AJAR10.1012
- Description: Only limited information is available in the literature on the role of soil mineral surfaces in the sorption of hydrophobic organic pollutants. This knowledge gap is addressed through the assessment of biphenyl sorption to kaolinite, illite and bentonite; using the batch equilibration technique with incubations lasting 6 or 21 days at 28 ± 2°C in the dark [RT1]. Sorption of biphenyl onto kaolinite followed the Freundlich sorption isotherm, whereas linear sorption isotherms were observed on illite and bentonite [RT2]. The biphenyl sorption partition coefficient on kaolinite ranged from 0.1 to 9.1 cm3.g-1 after 6 days and no sorption was observed after 21 days. This could have been caused by a completely reversible sorption or a loss of binding capacity after 21 days [RT3]. The respective values of the biphenyl sorption partition coefficient on illite and bentonite ranged from 20.3 ± 0.3 to 120 ± 8 cm3.g-1.Sorption equilibrium on the internal clay surfaces was reached after 6 days, as indicated by the sorption data for illite and bentonite [RT4]. Access of biphenyl molecules to the internal clay surfaces is a function of the ionic strength of soil solution and the soil organic matter is the dominant site for biphenyl sorption after 6 to 21 days.
- Full Text:
- Date Issued: 2011
- Authors: Tandlich, Roman , Baláž, Štefan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76869 , vital:30632 , https://doi.org/10.5897/AJAR10.1012
- Description: Only limited information is available in the literature on the role of soil mineral surfaces in the sorption of hydrophobic organic pollutants. This knowledge gap is addressed through the assessment of biphenyl sorption to kaolinite, illite and bentonite; using the batch equilibration technique with incubations lasting 6 or 21 days at 28 ± 2°C in the dark [RT1]. Sorption of biphenyl onto kaolinite followed the Freundlich sorption isotherm, whereas linear sorption isotherms were observed on illite and bentonite [RT2]. The biphenyl sorption partition coefficient on kaolinite ranged from 0.1 to 9.1 cm3.g-1 after 6 days and no sorption was observed after 21 days. This could have been caused by a completely reversible sorption or a loss of binding capacity after 21 days [RT3]. The respective values of the biphenyl sorption partition coefficient on illite and bentonite ranged from 20.3 ± 0.3 to 120 ± 8 cm3.g-1.Sorption equilibrium on the internal clay surfaces was reached after 6 days, as indicated by the sorption data for illite and bentonite [RT4]. Access of biphenyl molecules to the internal clay surfaces is a function of the ionic strength of soil solution and the soil organic matter is the dominant site for biphenyl sorption after 6 to 21 days.
- Full Text:
- Date Issued: 2011
Study of protein complexes via homology modeling, applied to cysteine proteases and their protein inhibitors:
- Tastan Bishop, Özlem, Kroon, Matthys
- Authors: Tastan Bishop, Özlem , Kroon, Matthys
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148070 , vital:38707 , DOI: 10.1007/s00894-011-0990-y
- Description: This paper develops and evaluates large-scale calculation of 3D structures of protein complexes by homology modeling as a promising new approach for protein docking. The complexes investigated were papain-like cysteine proteases and their protein inhibitors, which play numerous roles in human and parasitic metabolisms. The structural modeling was performed in two parts. For the first part (evaluation set), nine crystal structure complexes were selected, 1325 homology models of known complexes were rebuilt by various templates including hybrids, allowing an analysis of the factors influencing the accuracy of the models. The important considerations for modeling the interface were protease coverage and inhibitor sequence identity. In the second part (study set), the findings of the evaluation set were used to select appropriate templates to model novel cysteine protease-inhibitor complexes from human and malaria parasites Plasmodium falciparum and Plasmodium vivax. The energy scores, considering the evaluation set, indicate that the models are of high accuracy.
- Full Text:
- Date Issued: 2011
- Authors: Tastan Bishop, Özlem , Kroon, Matthys
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148070 , vital:38707 , DOI: 10.1007/s00894-011-0990-y
- Description: This paper develops and evaluates large-scale calculation of 3D structures of protein complexes by homology modeling as a promising new approach for protein docking. The complexes investigated were papain-like cysteine proteases and their protein inhibitors, which play numerous roles in human and parasitic metabolisms. The structural modeling was performed in two parts. For the first part (evaluation set), nine crystal structure complexes were selected, 1325 homology models of known complexes were rebuilt by various templates including hybrids, allowing an analysis of the factors influencing the accuracy of the models. The important considerations for modeling the interface were protease coverage and inhibitor sequence identity. In the second part (study set), the findings of the evaluation set were used to select appropriate templates to model novel cysteine protease-inhibitor complexes from human and malaria parasites Plasmodium falciparum and Plasmodium vivax. The energy scores, considering the evaluation set, indicate that the models are of high accuracy.
- Full Text:
- Date Issued: 2011