Secondary effects of oral contraceptives
- Authors: Yuen, E Ho
- Date: 1978
- Subjects: Oral contraceptives , Oral contraceptives -- Side effects
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3847 , http://hdl.handle.net/10962/d1012296
- Description: Norethynodrel, a common progestin in oral contraceptives, produces in female rats several significant physiological, cytological and biochemical changes at dose levels of 1 mg and 20 mg per kg: 1) a relative increase in liver mass 2) modification of appearance and extent of the endoplasmic reticulum 3) augmentation of the protein content of the liver 4) increase of the level of cytochrome P- 450 in the liver as determined by : a) difference spectroscopy b) increases in biotransformation of aniline and aminopyrine in vitro and c) reduction of sleeping times of rats dosed with phenobarbital The significance of these findings becomes evident when it is realized that norethynodrel affects and is affected by the same enzyme system which oxidizes medicaments in general in the body: induction of cytochrome P-450 by administration of norethynodrel may interfere with the action of other drugs . Ethinyl estradiol alone showed none of the inductive effects. At high dose levels (20 mg per kg) both norethynodrel and ethinyl estradiol caused a marked inhibition of growth of the animals, producing a net loss of body mass over the 30- day experimental period. Electron micrographic evidence implies that there is also a lowering of glycogen content and a chemical change in the lipids of adrenocortical and liver cells accompanying the use of these agents.
- Full Text:
- Date Issued: 1978
- Authors: Yuen, E Ho
- Date: 1978
- Subjects: Oral contraceptives , Oral contraceptives -- Side effects
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3847 , http://hdl.handle.net/10962/d1012296
- Description: Norethynodrel, a common progestin in oral contraceptives, produces in female rats several significant physiological, cytological and biochemical changes at dose levels of 1 mg and 20 mg per kg: 1) a relative increase in liver mass 2) modification of appearance and extent of the endoplasmic reticulum 3) augmentation of the protein content of the liver 4) increase of the level of cytochrome P- 450 in the liver as determined by : a) difference spectroscopy b) increases in biotransformation of aniline and aminopyrine in vitro and c) reduction of sleeping times of rats dosed with phenobarbital The significance of these findings becomes evident when it is realized that norethynodrel affects and is affected by the same enzyme system which oxidizes medicaments in general in the body: induction of cytochrome P-450 by administration of norethynodrel may interfere with the action of other drugs . Ethinyl estradiol alone showed none of the inductive effects. At high dose levels (20 mg per kg) both norethynodrel and ethinyl estradiol caused a marked inhibition of growth of the animals, producing a net loss of body mass over the 30- day experimental period. Electron micrographic evidence implies that there is also a lowering of glycogen content and a chemical change in the lipids of adrenocortical and liver cells accompanying the use of these agents.
- Full Text:
- Date Issued: 1978
Some aspects of the construction and implementation of error-correcting linear codes
- Authors: Booth, Geoffrey L
- Date: 1978
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:20967 , http://hdl.handle.net/10962/5718
- Description: From Conclusion: The study of error-correcting codes is now approximately 25 years old. The first known publication on the subject was in 1949 by M. Golay, who later did much research into the subject of perfect codes. It has been recently established that all the perfect codes are known. R.W. Hamming presented his perfect single-error correcting codes in 1950, in ~n article in the Bell System Technical Journal. These codes turned out to be a special case of the powerful Bose-Chaudhuri codes which were discovered around 1960. Various work has been done on the theory of minimal redundancy of codes for a given error-correcting performance, by Plotkin, Gilbert, Varshamov and others, between 1950 and 1960. The binary BCH codes were found to be so close to the theoretical bounds that, to date, no better codes have been discovered. Although the BCH codes are extremely efficient in terms of ratio of information to check digits, they are not easily, decoded with a minimal amount of apparatus. Petersen in 1961 described an algorithm for d e coding BCH codes, but this was cumbersome compared with the majority-logic methods of Massey and others. Thus the search began for codes which are easily decoded with comparatively simple apparatus. The finite geometry codes which were described by Rudolph in a 1964 thesis were examples of codes which are easily decoded 58 by a small number of steps of majority logic. The simplicial codes of Saltzer are even better in this respect, since they can be decoded by a single step of majority logic, but are rather inefficient . The applications of coding theory have changed over the years, as well. The first computers were huge circuits of relays, which were unreliable and prone to errors. Error correcting codes were required to minimise the possibility of incorrect results. As vacuum tubes and later transistorised circuits made computers more reliable, the need for sophisticated and powerful codes in the computer world diminished. Other used presented themselves however, for example the control systems of unmanned space craft. Because of the difficulty of sending and receiving messages in this case, · very powerful codes were required. Other uses were found in transmission lines and telephone exchanges. The codes considered in this dissertation have, for the most part, been block codes for use on the binary symmetric channel. There are, however, several other applications, such as codes for use on an erasure channel, where bits are corrupted so as to be unrecognizable, rather than changed. There are also codes for burst-error correction, where chennel noise is not randomly distributed, but occurs in "bursts" a few bits long. Certain cyclic codes are of application in these cases. The theory of error correcting codes has risen from virtual non-existence in 1950 to a major and sophisticated part of communication theory. Judging from the articles in journals, it promises to be the subject of a great deal of research for some years to come.
- Full Text:
- Date Issued: 1978
- Authors: Booth, Geoffrey L
- Date: 1978
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:20967 , http://hdl.handle.net/10962/5718
- Description: From Conclusion: The study of error-correcting codes is now approximately 25 years old. The first known publication on the subject was in 1949 by M. Golay, who later did much research into the subject of perfect codes. It has been recently established that all the perfect codes are known. R.W. Hamming presented his perfect single-error correcting codes in 1950, in ~n article in the Bell System Technical Journal. These codes turned out to be a special case of the powerful Bose-Chaudhuri codes which were discovered around 1960. Various work has been done on the theory of minimal redundancy of codes for a given error-correcting performance, by Plotkin, Gilbert, Varshamov and others, between 1950 and 1960. The binary BCH codes were found to be so close to the theoretical bounds that, to date, no better codes have been discovered. Although the BCH codes are extremely efficient in terms of ratio of information to check digits, they are not easily, decoded with a minimal amount of apparatus. Petersen in 1961 described an algorithm for d e coding BCH codes, but this was cumbersome compared with the majority-logic methods of Massey and others. Thus the search began for codes which are easily decoded with comparatively simple apparatus. The finite geometry codes which were described by Rudolph in a 1964 thesis were examples of codes which are easily decoded 58 by a small number of steps of majority logic. The simplicial codes of Saltzer are even better in this respect, since they can be decoded by a single step of majority logic, but are rather inefficient . The applications of coding theory have changed over the years, as well. The first computers were huge circuits of relays, which were unreliable and prone to errors. Error correcting codes were required to minimise the possibility of incorrect results. As vacuum tubes and later transistorised circuits made computers more reliable, the need for sophisticated and powerful codes in the computer world diminished. Other used presented themselves however, for example the control systems of unmanned space craft. Because of the difficulty of sending and receiving messages in this case, · very powerful codes were required. Other uses were found in transmission lines and telephone exchanges. The codes considered in this dissertation have, for the most part, been block codes for use on the binary symmetric channel. There are, however, several other applications, such as codes for use on an erasure channel, where bits are corrupted so as to be unrecognizable, rather than changed. There are also codes for burst-error correction, where chennel noise is not randomly distributed, but occurs in "bursts" a few bits long. Certain cyclic codes are of application in these cases. The theory of error correcting codes has risen from virtual non-existence in 1950 to a major and sophisticated part of communication theory. Judging from the articles in journals, it promises to be the subject of a great deal of research for some years to come.
- Full Text:
- Date Issued: 1978
Studies in ionospheric ray tracing
- Authors: Lambert, Sheridan
- Date: 1978 , 2013-10-21
- Subjects: Ionosphere -- Research -- Graphic methods , Ionospheric radio wave propagation -- Research , Ionograms , Ray tracing algorithms
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5501 , http://hdl.handle.net/10962/d1006906 , Ionosphere -- Research -- Graphic methods , Ionospheric radio wave propagation -- Research , Ionograms , Ray tracing algorithms
- Description: The use of ray tracing in the analysis of certain daytime ionograms recorded at Grahamstown is discussed in this thesis. A computer program has been modified and used to trace rays in the frequency range 1 - 30 MHz. Vertical, short distance oblique, and long distance oblique ionograms have been synthesized from the results and compared with experimental ionograms for Grahamstown, the Alice - Grahamstown transmission path (64 km), and the SANAE - Grahamstown transmission path (4470 km) respectively. Ray paths have been calculated and related in detail to the models of the ionosphere and geomagnetic field. The main features of the vertical and short distance oblique ionograms can, in general, be reproduced using spherically stratified ionosphere models with electron density profiles derived from vertical ionograms. A suitable model for the geomagnetic field is a tilted dipole equivalent to the actual field at Grahamstown. The two-hop mode is shown to be, usually, the lowest on the long distance oblique records. The ionosphere model is the principal limiting factor in reproducing such ionograms, and the most satisfactory results have been those obtained with a model in which electron density is assumed to vary linearly with latitude between the profiles at SANAE and Grahamstown. The promising results obtained by ray tracing with normal ionospheric conditions indicate that the method has further possibilities which could usefully be explored. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1978
- Authors: Lambert, Sheridan
- Date: 1978 , 2013-10-21
- Subjects: Ionosphere -- Research -- Graphic methods , Ionospheric radio wave propagation -- Research , Ionograms , Ray tracing algorithms
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5501 , http://hdl.handle.net/10962/d1006906 , Ionosphere -- Research -- Graphic methods , Ionospheric radio wave propagation -- Research , Ionograms , Ray tracing algorithms
- Description: The use of ray tracing in the analysis of certain daytime ionograms recorded at Grahamstown is discussed in this thesis. A computer program has been modified and used to trace rays in the frequency range 1 - 30 MHz. Vertical, short distance oblique, and long distance oblique ionograms have been synthesized from the results and compared with experimental ionograms for Grahamstown, the Alice - Grahamstown transmission path (64 km), and the SANAE - Grahamstown transmission path (4470 km) respectively. Ray paths have been calculated and related in detail to the models of the ionosphere and geomagnetic field. The main features of the vertical and short distance oblique ionograms can, in general, be reproduced using spherically stratified ionosphere models with electron density profiles derived from vertical ionograms. A suitable model for the geomagnetic field is a tilted dipole equivalent to the actual field at Grahamstown. The two-hop mode is shown to be, usually, the lowest on the long distance oblique records. The ionosphere model is the principal limiting factor in reproducing such ionograms, and the most satisfactory results have been those obtained with a model in which electron density is assumed to vary linearly with latitude between the profiles at SANAE and Grahamstown. The promising results obtained by ray tracing with normal ionospheric conditions indicate that the method has further possibilities which could usefully be explored. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1978
Studies on the fermentation of molasses by Clostridium acetobutylicum
- Authors: Barber, Jennifer Mary
- Date: 1978
- Subjects: Molasses , Clostridium acetobutylicum , Fermentation
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4084 , http://hdl.handle.net/10962/d1007611 , Molasses , Clostridium acetobutylicum , Fermentation
- Description: The bacterium Clostridium acetobutylicum produces acetone and n [subscript] - butanol from molasses in an industrial fermentation system. Although the bacterium has been cultured in liquid media it does not grow well on agar plates and requires high concentrations of hydrogen. Pretreatment of agar plates with bovine catalase improves growth on agar media. The bacteria produce an area of clearing (halo) on Potato agar plates due to butyric acid (the precursor of n [subscript]-butanol) and ß -amylase production. This characteristic will be used as a plate screening assay for the selection of high solvent producing mutants. A laboratory scale fermentation system was developed and detailed studies including pH, turbidity and cell morphology changes, and the details of solvent production were undertaken. The fermentation was optimized for mutant selection. The production of normal solvent yields by isolated clones is required for the mutant selection programme. Studies revealed that sporulation of the clones increased their solvent yield although solvent yields were still lower than normal. Efficient sporulation is therefore a prerequisite for clone fermentation. The origin of the phage infection during the factory outbreak was determined and resistant clones obtained. The presence of a bacteriocin-like toxin causing decreases in turbidity was identified during the final fermentation stage. The strain sensitivity, optimum conditions for stability as well as the kinetics of inactivation and lethality have been investigated. Preliminary characterization and purification studies indicate the proteinaceous nature of the toxin. , KMBT_363
- Full Text:
- Date Issued: 1978
- Authors: Barber, Jennifer Mary
- Date: 1978
- Subjects: Molasses , Clostridium acetobutylicum , Fermentation
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4084 , http://hdl.handle.net/10962/d1007611 , Molasses , Clostridium acetobutylicum , Fermentation
- Description: The bacterium Clostridium acetobutylicum produces acetone and n [subscript] - butanol from molasses in an industrial fermentation system. Although the bacterium has been cultured in liquid media it does not grow well on agar plates and requires high concentrations of hydrogen. Pretreatment of agar plates with bovine catalase improves growth on agar media. The bacteria produce an area of clearing (halo) on Potato agar plates due to butyric acid (the precursor of n [subscript]-butanol) and ß -amylase production. This characteristic will be used as a plate screening assay for the selection of high solvent producing mutants. A laboratory scale fermentation system was developed and detailed studies including pH, turbidity and cell morphology changes, and the details of solvent production were undertaken. The fermentation was optimized for mutant selection. The production of normal solvent yields by isolated clones is required for the mutant selection programme. Studies revealed that sporulation of the clones increased their solvent yield although solvent yields were still lower than normal. Efficient sporulation is therefore a prerequisite for clone fermentation. The origin of the phage infection during the factory outbreak was determined and resistant clones obtained. The presence of a bacteriocin-like toxin causing decreases in turbidity was identified during the final fermentation stage. The strain sensitivity, optimum conditions for stability as well as the kinetics of inactivation and lethality have been investigated. Preliminary characterization and purification studies indicate the proteinaceous nature of the toxin. , KMBT_363
- Full Text:
- Date Issued: 1978
Studies on the metabolism of SKF 525 A|
- Authors: Barber, Peter John
- Date: 1978 , 2013-10-14
- Subjects: Drugs -- Metabolism , Cytochrome P-450
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3835 , http://hdl.handle.net/10962/d1007591 , Drugs -- Metabolism , Cytochrome P-450
- Description: Spectrophotometric studies have been carried out to determine the pH dependence of binding of SKF 525 A, Brietal sodium and carbon monoxide to cytochrome P-450. The optimal pH for metabolic conversion of SKF 525 A has been investigated and this agent and its major metabolite, SKF 8742 A, have been metabolised in vitro by swine and rat hepatic microsomes. A suitable gas liquid chromatography assay has been developed and used to analyse metabolic production. The effects of carbon monoxide, dithiothreitol, n-octylamine and of induction of cytochrome P-450 by phenobarbital on metabolism of SKF 525 A and SKF 8742 A have been investigated. Attempts have been made to synthesise SKF 525 AN-oxide. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1978
- Authors: Barber, Peter John
- Date: 1978 , 2013-10-14
- Subjects: Drugs -- Metabolism , Cytochrome P-450
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3835 , http://hdl.handle.net/10962/d1007591 , Drugs -- Metabolism , Cytochrome P-450
- Description: Spectrophotometric studies have been carried out to determine the pH dependence of binding of SKF 525 A, Brietal sodium and carbon monoxide to cytochrome P-450. The optimal pH for metabolic conversion of SKF 525 A has been investigated and this agent and its major metabolite, SKF 8742 A, have been metabolised in vitro by swine and rat hepatic microsomes. A suitable gas liquid chromatography assay has been developed and used to analyse metabolic production. The effects of carbon monoxide, dithiothreitol, n-octylamine and of induction of cytochrome P-450 by phenobarbital on metabolism of SKF 525 A and SKF 8742 A have been investigated. Attempts have been made to synthesise SKF 525 AN-oxide. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1978
The endocoprid dung beetles of southern Africa (Coleoptera: Scarabaeidae)
- Davis, Adrian L V (Adrian Louis Victor)
- Authors: Davis, Adrian L V (Adrian Louis Victor)
- Date: 1978
- Subjects: Dung beetles -- Ecology , Dung beetles -- Africa, Southern
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5845 , http://hdl.handle.net/10962/d1011030 , Dung beetles -- Ecology , Dung beetles -- Africa, Southern
- Description: The biology and ecology of the endocoprid dung beetles of the Aethiopian zoogeographic region has been studied in the field and laboratory. Work has centred mainly on Oniticellus planatus and O. formoaus although infomation has also been supplied on O. egregius, O. pictus and Tragiscus dimidiatus. The taxonomy of Onticellus (s.str.) and Tragiscus has been discussed with the recommendation that O. planattus and O. pseudaplanatus be synonymised. It has been suggested that endocoprid distribution is chiefly controlled by temperature, rainfall and the density of suitable large dung masses. On the basis of distribution it has been suggested that the taxonomic status of the subspecies of O. pictus should be reviewed. Endocoprids (genus Oniticellus (s.str.) are found throughout the warmer regions of Africa and Asia. Tragiscus is found only in Africa. Methods are described for monitoring endocoprids in the field, for distinguishing freshly emerged from older specimens, and for breeding endocoprids under laboratory conditions. It has been shown that endocoprids breed within or just beneath large dung masses unlike most other members of the Scarabaeinae which actively bury dung and construct the their broods at depth in the soil. It has been shown that there is a restriction of breeding sites available to endocoprids due to the removal of dung by the Scarabaeinae beetles and the limited space available within dung pads. This has resulted in low endocoprid population numbers, a disadvantage, which has been countered by highly specialised but opportunistic breeding habits. The requirements of dung plasticity have limited the time available for breeding activity by most endocoprids (excluding O. egresius) so that both the reproductive system and the reproductive behaviour (cf. O. planatus) are geared to rapid egg and brood production. Large numbers of follicles are able to be produced over a short period. In the probable absence of feeding, this has possibly been allowed by the involvement of a well developed fat body. The broods are tended by the parent female during larval development and the follicles are gradually resorbed, probably to prevent starvation. Ovarian recovery is rapid once feeding recommences. Behavioural mechanisms have developed which boost the number of broods constructed and the rapidity with which they are produced. The duration of endocoprid colonisation and the timing of arrival at dung is shown to be related to the rate of pad desiccation which is chiefly controlled by temperature and degree of dung removal by other dung beetles. Precipitation may also play a part. Predation by vertebrates and other insects has been noted and a number of mechanisms are described which are probably protective. Two insect parasitoids of O. formosus larvae have been recorded. The potential use of endocoprids in the Australian dung and fly control project has been discussed and it is recommended that their introduction be considered of low priority. It is suggested that the endocoprids evolved from Euoniticellus type ancestors and that their behaviour complex nidification developed in response to harsh environmental factors, chiefly the danger of desiccation and competition for dung with other dung beetles. From a consideration of brood and brood chamber construction it is suggested that O. egresius is a relatively unspecialised endocoprid which may retain dry season aestivation and has not evolved much further than its probable Euoniticellus type ancestor. The broods are coated in clay and abandoned soon after construction. Greater specialisation is shown by O. planatus and O. formosus which exhibit brooding behaviour, increasing longevity, more specialised brood protection, increased potential fecundity and continuous activity throughout the year. O. formosus shows greater specialisation in brood production than O. planatus. Greatest specialisation is found in T. dimidiatus which exhibits a precise brooding period and low egg production. Brood construction is of a similar degree of specialisation to that of O. formosus. Activity is also continuous throughout the year. The comparative biology of the five southern African endocoprids is summarised in Table 35. Summary, p. 129-131.
- Full Text:
- Date Issued: 1978
- Authors: Davis, Adrian L V (Adrian Louis Victor)
- Date: 1978
- Subjects: Dung beetles -- Ecology , Dung beetles -- Africa, Southern
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5845 , http://hdl.handle.net/10962/d1011030 , Dung beetles -- Ecology , Dung beetles -- Africa, Southern
- Description: The biology and ecology of the endocoprid dung beetles of the Aethiopian zoogeographic region has been studied in the field and laboratory. Work has centred mainly on Oniticellus planatus and O. formoaus although infomation has also been supplied on O. egregius, O. pictus and Tragiscus dimidiatus. The taxonomy of Onticellus (s.str.) and Tragiscus has been discussed with the recommendation that O. planattus and O. pseudaplanatus be synonymised. It has been suggested that endocoprid distribution is chiefly controlled by temperature, rainfall and the density of suitable large dung masses. On the basis of distribution it has been suggested that the taxonomic status of the subspecies of O. pictus should be reviewed. Endocoprids (genus Oniticellus (s.str.) are found throughout the warmer regions of Africa and Asia. Tragiscus is found only in Africa. Methods are described for monitoring endocoprids in the field, for distinguishing freshly emerged from older specimens, and for breeding endocoprids under laboratory conditions. It has been shown that endocoprids breed within or just beneath large dung masses unlike most other members of the Scarabaeinae which actively bury dung and construct the their broods at depth in the soil. It has been shown that there is a restriction of breeding sites available to endocoprids due to the removal of dung by the Scarabaeinae beetles and the limited space available within dung pads. This has resulted in low endocoprid population numbers, a disadvantage, which has been countered by highly specialised but opportunistic breeding habits. The requirements of dung plasticity have limited the time available for breeding activity by most endocoprids (excluding O. egresius) so that both the reproductive system and the reproductive behaviour (cf. O. planatus) are geared to rapid egg and brood production. Large numbers of follicles are able to be produced over a short period. In the probable absence of feeding, this has possibly been allowed by the involvement of a well developed fat body. The broods are tended by the parent female during larval development and the follicles are gradually resorbed, probably to prevent starvation. Ovarian recovery is rapid once feeding recommences. Behavioural mechanisms have developed which boost the number of broods constructed and the rapidity with which they are produced. The duration of endocoprid colonisation and the timing of arrival at dung is shown to be related to the rate of pad desiccation which is chiefly controlled by temperature and degree of dung removal by other dung beetles. Precipitation may also play a part. Predation by vertebrates and other insects has been noted and a number of mechanisms are described which are probably protective. Two insect parasitoids of O. formosus larvae have been recorded. The potential use of endocoprids in the Australian dung and fly control project has been discussed and it is recommended that their introduction be considered of low priority. It is suggested that the endocoprids evolved from Euoniticellus type ancestors and that their behaviour complex nidification developed in response to harsh environmental factors, chiefly the danger of desiccation and competition for dung with other dung beetles. From a consideration of brood and brood chamber construction it is suggested that O. egresius is a relatively unspecialised endocoprid which may retain dry season aestivation and has not evolved much further than its probable Euoniticellus type ancestor. The broods are coated in clay and abandoned soon after construction. Greater specialisation is shown by O. planatus and O. formosus which exhibit brooding behaviour, increasing longevity, more specialised brood protection, increased potential fecundity and continuous activity throughout the year. O. formosus shows greater specialisation in brood production than O. planatus. Greatest specialisation is found in T. dimidiatus which exhibits a precise brooding period and low egg production. Brood construction is of a similar degree of specialisation to that of O. formosus. Activity is also continuous throughout the year. The comparative biology of the five southern African endocoprids is summarised in Table 35. Summary, p. 129-131.
- Full Text:
- Date Issued: 1978
The geochemistry and petrology of Karroo basalts of the Barkly East area, north eastern Cape
- Authors: Pemberton, John
- Date: 1978 , 2013-10-17
- Subjects: Basalt -- South Africa -- Eastern Cape , Petrology -- South Africa -- Eastern Cape , Geochemistry -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5042 , http://hdl.handle.net/10962/d1007646 , Basalt -- South Africa -- Eastern Cape , Petrology -- South Africa -- Eastern Cape , Geochemistry -- South Africa -- Eastern Cape
- Description: Sixty one basalt samples from the Drakensberg Subgroup in the Barkly East area were analysed for major elements and fourteen trace elements viz. Sr, Rb, Zr, Y, Nb, Zn, Cu, Ni, Co, V, Cr, La, Ce and Nd . These data confirm the tholeiitic nature of the Drakensberg Subgroup. Geochemical differences in the major element compositions are small within the different units of the Drakensberg Subgroup. Small differences are also evident between these units. The trace element variation between the units and within the Lesotho Formation are more pronounced than the variation of the major elements. The Lesotho Formation samples show a minor vertical increase in value for the top half of the Naudes Nek section in Fe, Ti, P, Zr, Nb, Y, La, Ce and Nd . A decrease in value from the same position in Mg, Ni and Co was observed. These patterns of variation are interpreted as representing low-pressure fractionation of plagioclase, olivine and clinopyroxene. Differences between the units of the Drakensberg Subgroup are examined by using absolute trace element contents and interelement ratios. Ratios of incompatible elements differ for the different units leading to the suggestion that a heterogeneous mantle is the most likely explanation for these differences. A unique unit of flows designated the Omega Formation is examined. The basal massive unit displays an unusual pattern of variation with height which suggests an origin through two different differentiation mechanisms. The data from this thesis are compared with those of Cox and Hornung (1966) on the central Lesotho basalts, Bristow (1976) on the southern Lebombo basalts and Robey (1976) on the Karroo dolerites of the Eastern Cape. The geochemical comparison between the lavas of the Lesotho Formation in the Barkly East area, central Lesotho and the Karroo dolerites show no major differences. However the southern Lebombo basalts show an enrichment in Sr and depletion in Cr.
- Full Text:
- Date Issued: 1978
- Authors: Pemberton, John
- Date: 1978 , 2013-10-17
- Subjects: Basalt -- South Africa -- Eastern Cape , Petrology -- South Africa -- Eastern Cape , Geochemistry -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5042 , http://hdl.handle.net/10962/d1007646 , Basalt -- South Africa -- Eastern Cape , Petrology -- South Africa -- Eastern Cape , Geochemistry -- South Africa -- Eastern Cape
- Description: Sixty one basalt samples from the Drakensberg Subgroup in the Barkly East area were analysed for major elements and fourteen trace elements viz. Sr, Rb, Zr, Y, Nb, Zn, Cu, Ni, Co, V, Cr, La, Ce and Nd . These data confirm the tholeiitic nature of the Drakensberg Subgroup. Geochemical differences in the major element compositions are small within the different units of the Drakensberg Subgroup. Small differences are also evident between these units. The trace element variation between the units and within the Lesotho Formation are more pronounced than the variation of the major elements. The Lesotho Formation samples show a minor vertical increase in value for the top half of the Naudes Nek section in Fe, Ti, P, Zr, Nb, Y, La, Ce and Nd . A decrease in value from the same position in Mg, Ni and Co was observed. These patterns of variation are interpreted as representing low-pressure fractionation of plagioclase, olivine and clinopyroxene. Differences between the units of the Drakensberg Subgroup are examined by using absolute trace element contents and interelement ratios. Ratios of incompatible elements differ for the different units leading to the suggestion that a heterogeneous mantle is the most likely explanation for these differences. A unique unit of flows designated the Omega Formation is examined. The basal massive unit displays an unusual pattern of variation with height which suggests an origin through two different differentiation mechanisms. The data from this thesis are compared with those of Cox and Hornung (1966) on the central Lesotho basalts, Bristow (1976) on the southern Lebombo basalts and Robey (1976) on the Karroo dolerites of the Eastern Cape. The geochemical comparison between the lavas of the Lesotho Formation in the Barkly East area, central Lesotho and the Karroo dolerites show no major differences. However the southern Lebombo basalts show an enrichment in Sr and depletion in Cr.
- Full Text:
- Date Issued: 1978
The in vivo and quantitative assessment of topical corticosteroid formulations
- Authors: Coleman, Gerald Leslie
- Date: 1978 , 2013-10-14
- Subjects: Dermatopharmacology , Dermatologic agents , Skin absorption , Adrenocortical hormones -- Therapeutic use , Transdermal medication -- Evaluation
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3857 , http://hdl.handle.net/10962/d1013337
- Full Text:
- Date Issued: 1978
- Authors: Coleman, Gerald Leslie
- Date: 1978 , 2013-10-14
- Subjects: Dermatopharmacology , Dermatologic agents , Skin absorption , Adrenocortical hormones -- Therapeutic use , Transdermal medication -- Evaluation
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3857 , http://hdl.handle.net/10962/d1013337
- Full Text:
- Date Issued: 1978
The study of the metabolism of phenylbutazone (4-butyl-1,2 -diphenylpyrazolidine - 3,5 - dione) in rats
- Authors: Alexander, Dorothy Mary
- Date: 1978 , 2013-10-18
- Subjects: Drugs -- Metabolism , Phenylbutazone
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3832 , http://hdl.handle.net/10962/d1007468 , Drugs -- Metabolism , Phenylbutazone
- Description: In this study the metabolism of the anti-arthritic drug, phenylbutazone, was investigated in female Wistar rats, and the results compared with those of other workers in this field. Two interrelated projects were undertaken. The first covered the pattern of excretion, isolation and characterisation of the metabolites and decomposition products of phenylbutazone in rats dosed post-orally with the drug. It was found that the major route of excretion was via the urine and over 50% of the administered dose was excreted in the first 24 hours by this route. A small percentage of the dose was excreted in the faeces. The following compounds were identified using chromatographic and autoradiographic techniques: p-Hydroxy derivative of phenylbutazone γ-Hydroxy derivative of phenylbutazone in both its molecular forms (ring lactone and straight chain hydroxyl) 4-Hydroxy derivative of phenylbutazone p-γ-Dihydroxy derivative of phenylbutazone p-4-Dihydroxy derivative of phenylbutazone Hydrolysable conjugates (possibly glucuronides) Water soluble non-hydrolysable conjugates. The second project dealt with the quantitation of the water insoluble compounds isolated in the initial work. Using a unique technique, combining inverse isotope dilution assay and spectrophotometric analysis, it was found that the major metabolite was the γ-hydroxy derivative of phenylbutazone, present in both its molecular forms. Oxyphenbutazone was a minor metabolite and the p-γ-dihydroxy derivative of phenylbutazone was present only in very low concentration. These results did not conform with those of previous workers in this field who reported the γ-hydroxy derivative of phenylbutazone, in one molecular form only, as the major metabolite and the dihydroxy derivative as the second metabolite with a higher concentration in the urine than oxyphenbutazone. This disparity could be due to the fact that these workers took no account of the presence of the two molecular forms of the γ-hydroxy derivative of phenylbutazone with their different polarities and different Rf values. The present study showed that the straight chain hydroxyl isomer was probably mistakenly identified as the p-γ-dihydroxy derivative of phenylbutazone. This theory is supported by the fact that the percentage dose recovered by the previous workers of the γ-hydroxy and p-γ-dihydroxy derivatives together equalled the percentage dose recovered in this study of the two molecular forms of the γ-hydroxy derivative. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1978
- Authors: Alexander, Dorothy Mary
- Date: 1978 , 2013-10-18
- Subjects: Drugs -- Metabolism , Phenylbutazone
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3832 , http://hdl.handle.net/10962/d1007468 , Drugs -- Metabolism , Phenylbutazone
- Description: In this study the metabolism of the anti-arthritic drug, phenylbutazone, was investigated in female Wistar rats, and the results compared with those of other workers in this field. Two interrelated projects were undertaken. The first covered the pattern of excretion, isolation and characterisation of the metabolites and decomposition products of phenylbutazone in rats dosed post-orally with the drug. It was found that the major route of excretion was via the urine and over 50% of the administered dose was excreted in the first 24 hours by this route. A small percentage of the dose was excreted in the faeces. The following compounds were identified using chromatographic and autoradiographic techniques: p-Hydroxy derivative of phenylbutazone γ-Hydroxy derivative of phenylbutazone in both its molecular forms (ring lactone and straight chain hydroxyl) 4-Hydroxy derivative of phenylbutazone p-γ-Dihydroxy derivative of phenylbutazone p-4-Dihydroxy derivative of phenylbutazone Hydrolysable conjugates (possibly glucuronides) Water soluble non-hydrolysable conjugates. The second project dealt with the quantitation of the water insoluble compounds isolated in the initial work. Using a unique technique, combining inverse isotope dilution assay and spectrophotometric analysis, it was found that the major metabolite was the γ-hydroxy derivative of phenylbutazone, present in both its molecular forms. Oxyphenbutazone was a minor metabolite and the p-γ-dihydroxy derivative of phenylbutazone was present only in very low concentration. These results did not conform with those of previous workers in this field who reported the γ-hydroxy derivative of phenylbutazone, in one molecular form only, as the major metabolite and the dihydroxy derivative as the second metabolite with a higher concentration in the urine than oxyphenbutazone. This disparity could be due to the fact that these workers took no account of the presence of the two molecular forms of the γ-hydroxy derivative of phenylbutazone with their different polarities and different Rf values. The present study showed that the straight chain hydroxyl isomer was probably mistakenly identified as the p-γ-dihydroxy derivative of phenylbutazone. This theory is supported by the fact that the percentage dose recovered by the previous workers of the γ-hydroxy and p-γ-dihydroxy derivatives together equalled the percentage dose recovered in this study of the two molecular forms of the γ-hydroxy derivative. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1978
A comparison of the performance of three conceptual mathematical models of the rainfall-runoff process in the Mareetsane Catchment
- Authors: Stickells Peter S
- Date: 1979
- Subjects: Rain and rainfall Mathematical models South Africa Runoff
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4793 , http://hdl.handle.net/10962/d1001893
- Description: The objective of the thesis is to make a critical assessment of the performance of three relatively simple deterministic models of the rainfall-runoff process. The need to evaluate and compare deterministic models arises because of the large number of models which are available in the literature. A number of the available models would appear to be equally suitable for a given situation whereas many models are found to be valid only under the specific range of conditions for which they were developed. Therefore there is a need for guidelines to allow the most judicious selection of a model for a particular set of circumstances. The models used in the study will be tested in a semi-arid catchment to determine their applicability under ephemeral flow conditions
- Full Text:
- Date Issued: 1979
- Authors: Stickells Peter S
- Date: 1979
- Subjects: Rain and rainfall Mathematical models South Africa Runoff
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4793 , http://hdl.handle.net/10962/d1001893
- Description: The objective of the thesis is to make a critical assessment of the performance of three relatively simple deterministic models of the rainfall-runoff process. The need to evaluate and compare deterministic models arises because of the large number of models which are available in the literature. A number of the available models would appear to be equally suitable for a given situation whereas many models are found to be valid only under the specific range of conditions for which they were developed. Therefore there is a need for guidelines to allow the most judicious selection of a model for a particular set of circumstances. The models used in the study will be tested in a semi-arid catchment to determine their applicability under ephemeral flow conditions
- Full Text:
- Date Issued: 1979
A computer-controlled tracking system
- Authors: Oberem, Graham Edmund
- Date: 1979
- Subjects: Artificial satellites -- Tracking
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5437 , http://hdl.handle.net/10962/d1001990
- Description: A computer-controlled tracking system has been designed and constructed for the two metre antenna of the 22 GHz radio telescope at Rhodes University. The control system has been tested and its step response has been analysed with a view to response time optimization. Computer programs for tracking the sun and the moon have been written. Initial results of tracking the sun have revealed linearity and temperature stability problems. These problems have been investigated and suggestions have been made as to how they might be removed
- Full Text:
- Date Issued: 1979
- Authors: Oberem, Graham Edmund
- Date: 1979
- Subjects: Artificial satellites -- Tracking
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5437 , http://hdl.handle.net/10962/d1001990
- Description: A computer-controlled tracking system has been designed and constructed for the two metre antenna of the 22 GHz radio telescope at Rhodes University. The control system has been tested and its step response has been analysed with a view to response time optimization. Computer programs for tracking the sun and the moon have been written. Initial results of tracking the sun have revealed linearity and temperature stability problems. These problems have been investigated and suggestions have been made as to how they might be removed
- Full Text:
- Date Issued: 1979
A re-examination of the Carter solutions of Einstein's field equations
- Authors: Kun, A Ah
- Date: 1979
- Subjects: Einstein field equations Space and time General relativity (Physics)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5442 , http://hdl.handle.net/10962/d1001995
- Description: The study of geodesics in space-time is essential to a comprehensive understanding of the physics of the field. Global properties, e.g. the singularity structure and completeness of space-time, can be related to the geodesic properties, thus it is through the solutions of the geodesic equation of motion that many of the global properties of space-time can be obtained in an easily interpretable form. However, it is usually very difficult to integrate the geodesic equations for the particle motion in the presence of a gravitational field (Introduction, p. 1)
- Full Text:
- Date Issued: 1979
- Authors: Kun, A Ah
- Date: 1979
- Subjects: Einstein field equations Space and time General relativity (Physics)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5442 , http://hdl.handle.net/10962/d1001995
- Description: The study of geodesics in space-time is essential to a comprehensive understanding of the physics of the field. Global properties, e.g. the singularity structure and completeness of space-time, can be related to the geodesic properties, thus it is through the solutions of the geodesic equation of motion that many of the global properties of space-time can be obtained in an easily interpretable form. However, it is usually very difficult to integrate the geodesic equations for the particle motion in the presence of a gravitational field (Introduction, p. 1)
- Full Text:
- Date Issued: 1979
A review of landscape development and erosion cycles in southern Africa
- Authors: Corbett, Dudley Harold
- Date: 1979
- Subjects: Landscape changes -- Africa, Southern Erosion -- Africa, Southern
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4899 , http://hdl.handle.net/10962/d1001558
- Description: The study of landforms has, to a large extent been neglected by exploration geologists. This is surprising because field geology is intimately related with landforms of one type or another. An understanding of the geomorphological history of a particular area will assist in the appreciation of the surficial environment, the processes of weathering, soil formation and duricrust (calcrete , ferricrete silcrete) formation. This has direct application in planning and interpreting geochemical sampling programmes. In order to understand the evolution of landforms it is necessary to study slope development in some detail. Agents of erosion and denudation constantly at work, remove detritus from hillcrests down to the drainage lines which form the local base level from whence material is transported down to the sea. The system is one of dynamic equilibrium, and the concept of grade is important in understanding hillslope evolution. Thus Section (1) of this discussion deals with past and present theories of hillslope evolution. Very little work has been done recently on the geomorphology of Southern Africa and the presently accepted classification of land surfaces is based on the work of Prof. L.C. King (numerous publications). However, through the more recent work of De Swardt and Bennet (1974) on the geomorphology of Natal, it is apparent that the present system of landform classification in Southern Africa requires widespread revision. The relationship of erosion cycles in Southern Africa to the late Jurassic-early Cretaceous break-up of Gondwanaland has received insufficient attention in the past. Erosion cycles bear an intimate relationship to offshore Cretaceous and Tertiary-Recent sedimentation. Valuable information on these sediments has only recently become available as a result of offshore exploration for oil. The findings of De Swardt and Bennet (1974) are summarized in Section (2) and the present land surface classification of Southern Africa is reviewed. Finally, some suggestions on a new interpretation of land surfaces in Southern Africa are given.
- Full Text:
- Date Issued: 1979
- Authors: Corbett, Dudley Harold
- Date: 1979
- Subjects: Landscape changes -- Africa, Southern Erosion -- Africa, Southern
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4899 , http://hdl.handle.net/10962/d1001558
- Description: The study of landforms has, to a large extent been neglected by exploration geologists. This is surprising because field geology is intimately related with landforms of one type or another. An understanding of the geomorphological history of a particular area will assist in the appreciation of the surficial environment, the processes of weathering, soil formation and duricrust (calcrete , ferricrete silcrete) formation. This has direct application in planning and interpreting geochemical sampling programmes. In order to understand the evolution of landforms it is necessary to study slope development in some detail. Agents of erosion and denudation constantly at work, remove detritus from hillcrests down to the drainage lines which form the local base level from whence material is transported down to the sea. The system is one of dynamic equilibrium, and the concept of grade is important in understanding hillslope evolution. Thus Section (1) of this discussion deals with past and present theories of hillslope evolution. Very little work has been done recently on the geomorphology of Southern Africa and the presently accepted classification of land surfaces is based on the work of Prof. L.C. King (numerous publications). However, through the more recent work of De Swardt and Bennet (1974) on the geomorphology of Natal, it is apparent that the present system of landform classification in Southern Africa requires widespread revision. The relationship of erosion cycles in Southern Africa to the late Jurassic-early Cretaceous break-up of Gondwanaland has received insufficient attention in the past. Erosion cycles bear an intimate relationship to offshore Cretaceous and Tertiary-Recent sedimentation. Valuable information on these sediments has only recently become available as a result of offshore exploration for oil. The findings of De Swardt and Bennet (1974) are summarized in Section (2) and the present land surface classification of Southern Africa is reviewed. Finally, some suggestions on a new interpretation of land surfaces in Southern Africa are given.
- Full Text:
- Date Issued: 1979
A review of the economic geology of tungsten
- Authors: Bowles, Michael
- Date: 1979
- Subjects: Tungsten Geology, Economic
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4897 , http://hdl.handle.net/10962/d1001556
- Description: A description of the geochemistry of tungsten is given. The geochemical properties of tungsten have a strong influence on its mineralogy, distribution and abundance in crustal rocks and rock-forming minerals , and its migration/deposition within the ore-forming and supergene environments. The behaviour of tungsten during migration, from source to site of deposition, within the crust is discussed in some detail and environments considered favourable to the concentration of tungsten ore minerals are suggested. All major types of tungsten ore deposit are described with emphasis placed on those of greater economic importance. Characteristic features of each type of deposit are particularly emphasized in order to provide clear guidelines to exploration. Hydrothermal, pyrometasomatic and stratabound tungsten deposits present themselves, economically, as the most important exploration targets. The recently developed concept of syngenetic stratabound tungsten mineralisation is outlined. Exploration for deposits of this type should be aimed predominantly, but not exclusively, at volcano-sedimentary sequences of Lower Palaeozoic age, particularly within regions known to contain occurrences of Sb and Hg. Tungsten deposits commonly contain concentrations of one or more of the following metals: Sn, Sb, Bi, Mo, Au and Ag. The presence and possible extractive value of these metals, together with commonly associated metal impurities such as As, must always be taken into account in a feasibility study , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 1979
- Authors: Bowles, Michael
- Date: 1979
- Subjects: Tungsten Geology, Economic
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4897 , http://hdl.handle.net/10962/d1001556
- Description: A description of the geochemistry of tungsten is given. The geochemical properties of tungsten have a strong influence on its mineralogy, distribution and abundance in crustal rocks and rock-forming minerals , and its migration/deposition within the ore-forming and supergene environments. The behaviour of tungsten during migration, from source to site of deposition, within the crust is discussed in some detail and environments considered favourable to the concentration of tungsten ore minerals are suggested. All major types of tungsten ore deposit are described with emphasis placed on those of greater economic importance. Characteristic features of each type of deposit are particularly emphasized in order to provide clear guidelines to exploration. Hydrothermal, pyrometasomatic and stratabound tungsten deposits present themselves, economically, as the most important exploration targets. The recently developed concept of syngenetic stratabound tungsten mineralisation is outlined. Exploration for deposits of this type should be aimed predominantly, but not exclusively, at volcano-sedimentary sequences of Lower Palaeozoic age, particularly within regions known to contain occurrences of Sb and Hg. Tungsten deposits commonly contain concentrations of one or more of the following metals: Sn, Sb, Bi, Mo, Au and Ag. The presence and possible extractive value of these metals, together with commonly associated metal impurities such as As, must always be taken into account in a feasibility study , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 1979
Adreno-active substances and the pineal gland
- Authors: Midlane, Graham Wallace
- Date: 1979
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3738 , http://hdl.handle.net/10962/d1001530
- Description: The pineal gland, a biochemically very active neuroendocrine transducer which is innervated by the sympathetic nervous system, was used in vivo to evaluate the effect of different þ-adrenoceptor agonists and antagonists on pineal enzyme levels. Hydroxyindole-O-methyltransferase (HIOMT), an enzyme with a circadian activity and unknown control was not significantly affected by these drugs. The activity of serotonin N-acetyltransferase, another pineal enzyme with a greater amplitude of circadian rhythmicity and which is under noradrenergic neural control, the degree of blockade depending on the selectivity and affinity of the agent used. An attempt was also made to alter the oestrous cycle of the rat by dosing with þ-active substances. Only propranolol had any effect on the oestrous cycle. It was not possible to establish an absolute link between the alteration in pineal enzyme activity and an influence on the oestrous cycle. It was concluded that the pineal enzyme studies are useful pharmacological means for evaluating þ-active substances
- Full Text:
- Date Issued: 1979
- Authors: Midlane, Graham Wallace
- Date: 1979
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3738 , http://hdl.handle.net/10962/d1001530
- Description: The pineal gland, a biochemically very active neuroendocrine transducer which is innervated by the sympathetic nervous system, was used in vivo to evaluate the effect of different þ-adrenoceptor agonists and antagonists on pineal enzyme levels. Hydroxyindole-O-methyltransferase (HIOMT), an enzyme with a circadian activity and unknown control was not significantly affected by these drugs. The activity of serotonin N-acetyltransferase, another pineal enzyme with a greater amplitude of circadian rhythmicity and which is under noradrenergic neural control, the degree of blockade depending on the selectivity and affinity of the agent used. An attempt was also made to alter the oestrous cycle of the rat by dosing with þ-active substances. Only propranolol had any effect on the oestrous cycle. It was not possible to establish an absolute link between the alteration in pineal enzyme activity and an influence on the oestrous cycle. It was concluded that the pineal enzyme studies are useful pharmacological means for evaluating þ-active substances
- Full Text:
- Date Issued: 1979
An automatic programming system to generate payroll programs
- Fielding, Elizabeth Vera Catherine
- Authors: Fielding, Elizabeth Vera Catherine
- Date: 1979
- Subjects: Computer software -- Development , Programming (computers) , Software architecture
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4695 , http://hdl.handle.net/10962/d1011829 , Computer software -- Development , Programming (computers) , Software architecture
- Description: The purpose of this project was to try to investigate one approach to the problem of automatically generating programs from some specification. Rather than following the approach which requires the user to define his problem using some formulation, it was decided to look at a class of problems that have similar solutions, but have many variations, and to try to design a system capable of obtaining user requirements and generating solutions tailored to these requirements. The aim was to design the system in such a way that it could be extended to cater for other classes of problems, so that eventually a system which could automatically generate program solutions for a range of problems might be developed. Intro. p. 1.
- Full Text:
- Date Issued: 1979
- Authors: Fielding, Elizabeth Vera Catherine
- Date: 1979
- Subjects: Computer software -- Development , Programming (computers) , Software architecture
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4695 , http://hdl.handle.net/10962/d1011829 , Computer software -- Development , Programming (computers) , Software architecture
- Description: The purpose of this project was to try to investigate one approach to the problem of automatically generating programs from some specification. Rather than following the approach which requires the user to define his problem using some formulation, it was decided to look at a class of problems that have similar solutions, but have many variations, and to try to design a system capable of obtaining user requirements and generating solutions tailored to these requirements. The aim was to design the system in such a way that it could be extended to cater for other classes of problems, so that eventually a system which could automatically generate program solutions for a range of problems might be developed. Intro. p. 1.
- Full Text:
- Date Issued: 1979
Aspects of the bioavailability of topical corticosteroid formulations
- Authors: Magnus, Ashley Denis
- Date: 1979
- Subjects: Adrenocortical hormones , Dermatopharmacology , Dermatologic agents , Transdermal medication
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3724 , http://hdl.handle.net/10962/d1001458
- Description: Two possible variables of the McKenzie/Stoughton blanching assay, namely amount applied to the test site and occlusion time have been investigated. Subsequently, two topical steroid preparations, Synalar cream (0,025% fluocinolone acetonide) and Betnovate cream (0,1% betamethasone 17- valerate) were extemporaneously diluted with five and six placebo bases respectively. Taking cognizance of the two possible variables, these diluted preparations were assessed in vivo using a modified version of the McKenzie/Stoughton blanching assay for blanching activity over a 14 month period. It was found that the base E45, which is slightly alkali, had the greatest effect on both preparations. In the case of betamethasone 17-valerate this base caused the conversion to the less active isomer, betamethasone 21-valerate whereas at the end of the 14 month test period it was found that the Synalar/E45 dilution contained no fluocinolone acetonide. Quantitative analysis of all the diluted preparations by high performance liquid chromatography using a reverse-phase system was performed. The data obtained from the systematic studies of the effects of varying concentrations and occlusion times were presented at the Eleventh National Congress of the South African Pharmacological Society
- Full Text:
- Date Issued: 1979
- Authors: Magnus, Ashley Denis
- Date: 1979
- Subjects: Adrenocortical hormones , Dermatopharmacology , Dermatologic agents , Transdermal medication
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3724 , http://hdl.handle.net/10962/d1001458
- Description: Two possible variables of the McKenzie/Stoughton blanching assay, namely amount applied to the test site and occlusion time have been investigated. Subsequently, two topical steroid preparations, Synalar cream (0,025% fluocinolone acetonide) and Betnovate cream (0,1% betamethasone 17- valerate) were extemporaneously diluted with five and six placebo bases respectively. Taking cognizance of the two possible variables, these diluted preparations were assessed in vivo using a modified version of the McKenzie/Stoughton blanching assay for blanching activity over a 14 month period. It was found that the base E45, which is slightly alkali, had the greatest effect on both preparations. In the case of betamethasone 17-valerate this base caused the conversion to the less active isomer, betamethasone 21-valerate whereas at the end of the 14 month test period it was found that the Synalar/E45 dilution contained no fluocinolone acetonide. Quantitative analysis of all the diluted preparations by high performance liquid chromatography using a reverse-phase system was performed. The data obtained from the systematic studies of the effects of varying concentrations and occlusion times were presented at the Eleventh National Congress of the South African Pharmacological Society
- Full Text:
- Date Issued: 1979
Gold mineralization in archaean cherts and iron-formations a review of the economic geology
- Authors: Bellamy, R E S
- Date: 1979
- Subjects: Gold ores -- Geology -- South Africa , Gold mines and mining -- South Africa , Greenstone belts -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4968 , http://hdl.handle.net/10962/d1005580 , Gold ores -- Geology -- South Africa , Gold mines and mining -- South Africa , Greenstone belts -- South Africa
- Description: The distribution of gold in igneous rocks and minerals is described and discussed. Not all the gold in igneous rocks is contained within early formed crystal lattices. Evidence that gold can be associated with late stage crystallizing phases is described. It is concluded that some of the gold in hydrothermal and volcanogenic deposits may have come from a primary magmatic source rather than having been leached from solid country rock. Gold is probably transported as chloride complexes at temperatures greater than about 300°C. At lower temperatures it is probably transported with other metals as sulphide and thio-sulphide complexes. The precipitation of gold from the transporting medium is brought about by changes in the physico-chemical conditions within that medium. Decrease in pressure is probably not a major cause of precipitation in volcanogenic environments. The geology of volcanogenic iron-formations is described and discussed, relative to the development of greenstone belts. Oxide facies iron-formations were formed in shallow oxidizing environments. They are associated with volcanogenic and clastic sediments. Sulphide facies iron-formations were precipitated in the deeper parts of geosynclinal structures. They are associated with mafic and ultramafic rocks similar to modern oceanic volcanic assemblages. Carbonate facies iron-formations were deposited in the regions between oxide facies and sulphide facies. Other banded iron-formations are found associated with base metal massive sulphide deposits related to arctype volcanic centres. These deposits are found in the regions where carbonate facies iron-formations were formed. Exploration for and exploitation of gold deposits in Archaean iron-formations are discussed. Geochemical exploration programmes are aided by the association of gold with trace amounts of base metals. Geophysical exploration methods that can be employed include magnetometer, I.P. and E.M. surveys. The metallurgical treatment of the ores should include "roasting" because a large proportion of the gold occurs as submicroscopic grains within sulphide mineral crystals.
- Full Text:
- Date Issued: 1979
- Authors: Bellamy, R E S
- Date: 1979
- Subjects: Gold ores -- Geology -- South Africa , Gold mines and mining -- South Africa , Greenstone belts -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4968 , http://hdl.handle.net/10962/d1005580 , Gold ores -- Geology -- South Africa , Gold mines and mining -- South Africa , Greenstone belts -- South Africa
- Description: The distribution of gold in igneous rocks and minerals is described and discussed. Not all the gold in igneous rocks is contained within early formed crystal lattices. Evidence that gold can be associated with late stage crystallizing phases is described. It is concluded that some of the gold in hydrothermal and volcanogenic deposits may have come from a primary magmatic source rather than having been leached from solid country rock. Gold is probably transported as chloride complexes at temperatures greater than about 300°C. At lower temperatures it is probably transported with other metals as sulphide and thio-sulphide complexes. The precipitation of gold from the transporting medium is brought about by changes in the physico-chemical conditions within that medium. Decrease in pressure is probably not a major cause of precipitation in volcanogenic environments. The geology of volcanogenic iron-formations is described and discussed, relative to the development of greenstone belts. Oxide facies iron-formations were formed in shallow oxidizing environments. They are associated with volcanogenic and clastic sediments. Sulphide facies iron-formations were precipitated in the deeper parts of geosynclinal structures. They are associated with mafic and ultramafic rocks similar to modern oceanic volcanic assemblages. Carbonate facies iron-formations were deposited in the regions between oxide facies and sulphide facies. Other banded iron-formations are found associated with base metal massive sulphide deposits related to arctype volcanic centres. These deposits are found in the regions where carbonate facies iron-formations were formed. Exploration for and exploitation of gold deposits in Archaean iron-formations are discussed. Geochemical exploration programmes are aided by the association of gold with trace amounts of base metals. Geophysical exploration methods that can be employed include magnetometer, I.P. and E.M. surveys. The metallurgical treatment of the ores should include "roasting" because a large proportion of the gold occurs as submicroscopic grains within sulphide mineral crystals.
- Full Text:
- Date Issued: 1979
Sedimentology of the Katberg sandstone in the Eastern Cape Province
- Authors: Stavrakis, Nicholas
- Date: 1979 , 2013-10-16
- Subjects: Sedimentology -- South Africa -- Eastern Cape , Geology, Stratigraphic -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5034 , http://hdl.handle.net/10962/d1007355 , Sedimentology -- South Africa -- Eastern Cape , Geology, Stratigraphic -- South Africa -- Eastern Cape
- Description: The Katberg Sandstone is an arenaceous formation occuring stratigraphically three querters of the way up in the Beaufort Group in the south-eastern part of the main Karoo basin. A sedimentological study was carried out on the Katberg Sandstone and adjacent formations, in a 2 000 km² area south of Queenstown. Stratigraphic sections were measured and lithofacies based on the style of Miall (1977) were established for the Katberg Sandstone, Balfour and Burgersdorp Formations. Stratigraphic relationships show that the Burgersdorp Formation in the study area, is the lateral (distal) equivalent of the Katberg Sandstone. The changeover from sandstone to predominantly shale lithology occurs roughly east-west between Cathcart and Whittlesea. Stream hydraulic theory is discussed and the sedimentary structures of the various lithofacies are explained in terms of this theory. An analysis was done of thirty-four palaeochannels, and their various ancient flow characteristics were derived via multiple regression equations and a FORTRAN computer program. A statistical analysis of bedform structures, showed that flat-bedding of the upper flow regime is the dominant sedimentary structure of the Katberg Sandstone. Trough cross-bedding originating in aqueous dunes and planar cross-bedding of transverse bars, are fairly well represented while ripples are virtually absent. The opposite applies to the Balfour Formation where lower flow regime structures, viz., ripple cross-lamination and trough cross-bedding predominate. There is an even spread of (upper) flat-bedding, trough cross-bedding and ripple cross-lamination in the Burgersdorp Formation. Detailed measurement of typical short sequences from sections of the three formations, and transition matrix analyses, showed the facies assemblages to be of three stream types: (i) Katberg type: similar to Platte type of Miall (1977). Sediments were deposited by swiftly flowing, low sinuosity, braided, ephemeral streams with a predominantly sand bedload. Each flow started with preconsolidated silt and mud (flakes), and movement of exogenetic pebble lags. Channel avulsion and deposition of mud drapes in higher topographic levels of the stream were common phenomena. (ii) Balfour type: characterised by lateral accretion point bar type sequences of high sinuosity streams, and vertical accretion floodplain deposits. Lower flow regime dune and ripple bedform structures overlying (upper) flat-beds indicate a loss of stream power with channel migration. (iii) Burgersdorp type: similar to Katberg type for sandstone units, also crevasse-splays onto thick subaerially exposed floodplain aggradation reddish shales. Conventional microscopy and SEM studies showed tremendous diagenetic effects mostly in the form of secondary quartz growth in the sandstones of the three formations. Electron microprobe analyses were done on titanomagnetite grains from heavy mineral layers of the Katberg Sandstone, so that thermometric predictions could be made on provenance rocks. Palaeocurrents of the Katberg Sandstone are mostly Rank 4 and 5 types (Miall, 1974), i.e., they were generated within bars with not much change in stream orientation. Burgersdorp and Balfour formation palaeocurrents are Rank 1 - 3 types. In the case of the former this is owing to directional changes in channels as a result of frequent crevasse-splays, and in the case of the latter owing to differences in orientation between entire tracts of highly sinuous palaeostreams. Palaeocurrent directions in the Katberg Sandstone indicate a southeasterly provenance which accords with the findings of other Beaufort Group workers. Bed relief index calculations (Smith, 1970), made on Katberg rocks, considered together with the abundance of planar cross-bedding (of transverse bars) and apparent absence of longitudinal bars, testify to the deposition of the Katberg Sandstone in the distal parts of the braided stream environment. The Beaufort sediments of the study area have the sedimentological characteristics of a molasse sequence, but a different implied tectonogenesis. During Balfour sedimentation the equilibrium base was being raised very slowly at the source and complete fluvial sequences were deposited under a humid temperate climate, on a slowly subsiding plain. During Katberg/Burgersdorp times, source area tectonism was pronounced but interrupted and incomplete sequences were deposited under an arid climate. Provenance rocks for the formations studied included biotite mesoperthitic granite, granulite, charnockite, granite porphyry, granophyre, metaquartzite, greenschist and possibly diorite, epidosit e and alkaline volcanic rocks. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1979
- Authors: Stavrakis, Nicholas
- Date: 1979 , 2013-10-16
- Subjects: Sedimentology -- South Africa -- Eastern Cape , Geology, Stratigraphic -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5034 , http://hdl.handle.net/10962/d1007355 , Sedimentology -- South Africa -- Eastern Cape , Geology, Stratigraphic -- South Africa -- Eastern Cape
- Description: The Katberg Sandstone is an arenaceous formation occuring stratigraphically three querters of the way up in the Beaufort Group in the south-eastern part of the main Karoo basin. A sedimentological study was carried out on the Katberg Sandstone and adjacent formations, in a 2 000 km² area south of Queenstown. Stratigraphic sections were measured and lithofacies based on the style of Miall (1977) were established for the Katberg Sandstone, Balfour and Burgersdorp Formations. Stratigraphic relationships show that the Burgersdorp Formation in the study area, is the lateral (distal) equivalent of the Katberg Sandstone. The changeover from sandstone to predominantly shale lithology occurs roughly east-west between Cathcart and Whittlesea. Stream hydraulic theory is discussed and the sedimentary structures of the various lithofacies are explained in terms of this theory. An analysis was done of thirty-four palaeochannels, and their various ancient flow characteristics were derived via multiple regression equations and a FORTRAN computer program. A statistical analysis of bedform structures, showed that flat-bedding of the upper flow regime is the dominant sedimentary structure of the Katberg Sandstone. Trough cross-bedding originating in aqueous dunes and planar cross-bedding of transverse bars, are fairly well represented while ripples are virtually absent. The opposite applies to the Balfour Formation where lower flow regime structures, viz., ripple cross-lamination and trough cross-bedding predominate. There is an even spread of (upper) flat-bedding, trough cross-bedding and ripple cross-lamination in the Burgersdorp Formation. Detailed measurement of typical short sequences from sections of the three formations, and transition matrix analyses, showed the facies assemblages to be of three stream types: (i) Katberg type: similar to Platte type of Miall (1977). Sediments were deposited by swiftly flowing, low sinuosity, braided, ephemeral streams with a predominantly sand bedload. Each flow started with preconsolidated silt and mud (flakes), and movement of exogenetic pebble lags. Channel avulsion and deposition of mud drapes in higher topographic levels of the stream were common phenomena. (ii) Balfour type: characterised by lateral accretion point bar type sequences of high sinuosity streams, and vertical accretion floodplain deposits. Lower flow regime dune and ripple bedform structures overlying (upper) flat-beds indicate a loss of stream power with channel migration. (iii) Burgersdorp type: similar to Katberg type for sandstone units, also crevasse-splays onto thick subaerially exposed floodplain aggradation reddish shales. Conventional microscopy and SEM studies showed tremendous diagenetic effects mostly in the form of secondary quartz growth in the sandstones of the three formations. Electron microprobe analyses were done on titanomagnetite grains from heavy mineral layers of the Katberg Sandstone, so that thermometric predictions could be made on provenance rocks. Palaeocurrents of the Katberg Sandstone are mostly Rank 4 and 5 types (Miall, 1974), i.e., they were generated within bars with not much change in stream orientation. Burgersdorp and Balfour formation palaeocurrents are Rank 1 - 3 types. In the case of the former this is owing to directional changes in channels as a result of frequent crevasse-splays, and in the case of the latter owing to differences in orientation between entire tracts of highly sinuous palaeostreams. Palaeocurrent directions in the Katberg Sandstone indicate a southeasterly provenance which accords with the findings of other Beaufort Group workers. Bed relief index calculations (Smith, 1970), made on Katberg rocks, considered together with the abundance of planar cross-bedding (of transverse bars) and apparent absence of longitudinal bars, testify to the deposition of the Katberg Sandstone in the distal parts of the braided stream environment. The Beaufort sediments of the study area have the sedimentological characteristics of a molasse sequence, but a different implied tectonogenesis. During Balfour sedimentation the equilibrium base was being raised very slowly at the source and complete fluvial sequences were deposited under a humid temperate climate, on a slowly subsiding plain. During Katberg/Burgersdorp times, source area tectonism was pronounced but interrupted and incomplete sequences were deposited under an arid climate. Provenance rocks for the formations studied included biotite mesoperthitic granite, granulite, charnockite, granite porphyry, granophyre, metaquartzite, greenschist and possibly diorite, epidosit e and alkaline volcanic rocks. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
- Full Text:
- Date Issued: 1979
The behaviour of the elements Ni, Co, Cu, Pb, Zn, Au, Ag, Mo, Sn, W and U in the magmatic, hydrothermal, sedimentary and weathering environments
- Authors: Anderson, J R
- Date: 1979
- Subjects: Elements , Environment , Ore deposits , Classification , Geochemistry , Crystal chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4896 , http://hdl.handle.net/10962/d1001555
- Description: In the last two decades much has been published on the behaviour of certain elements in the magmatic , hydrothermal, sedimentary and weathering environments , but the information is scattered throughout the literature . This situation prompted the present study on the elements Ni, Co, Cu, Pb , Zn , Au, Ag , Mo , Sn, W and U. The behaviour of the elements Ni, Cu, Pb , ZN, Au, Sn , W and U has been studied experimentally in some depth. Ag has been moderately studied, but there is very little information about Co and Mo. Studies on the complexes formed by the elements within the hydrothermal and aqueous environment are often inconclusive and controversial , but conclusions are drawn as to the more likely complexes formed . A genetic classification of ore deposits is used as a framework for the discussion . The source of the elements is regarded as being the mantle, and therefore discussion on other possible sources is beyond the scope of this dissertation. The crystal chemistry and geochemistry of the elements are presented and the essay concludes with a discussion on the elements within their depositional environments
- Full Text:
- Date Issued: 1979
- Authors: Anderson, J R
- Date: 1979
- Subjects: Elements , Environment , Ore deposits , Classification , Geochemistry , Crystal chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4896 , http://hdl.handle.net/10962/d1001555
- Description: In the last two decades much has been published on the behaviour of certain elements in the magmatic , hydrothermal, sedimentary and weathering environments , but the information is scattered throughout the literature . This situation prompted the present study on the elements Ni, Co, Cu, Pb , Zn , Au, Ag , Mo , Sn, W and U. The behaviour of the elements Ni, Cu, Pb , ZN, Au, Sn , W and U has been studied experimentally in some depth. Ag has been moderately studied, but there is very little information about Co and Mo. Studies on the complexes formed by the elements within the hydrothermal and aqueous environment are often inconclusive and controversial , but conclusions are drawn as to the more likely complexes formed . A genetic classification of ore deposits is used as a framework for the discussion . The source of the elements is regarded as being the mantle, and therefore discussion on other possible sources is beyond the scope of this dissertation. The crystal chemistry and geochemistry of the elements are presented and the essay concludes with a discussion on the elements within their depositional environments
- Full Text:
- Date Issued: 1979