Heat shock protein inhibitors: success stories
- McAlpine, Shelli R, Edkins, Adrienne L
- Authors: McAlpine, Shelli R , Edkins, Adrienne L
- Date: 2016
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66359 , vital:28940 , https://doi.org/10.1007/978-3-319-32607-8
- Description: publisher version , Introduction: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. , This work is based on the research supported by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa (Grant No 98566), the Cancer Association of South Africa (CANSA), Medical Research Council South Africa (MRC-SA) and Rhodes University. The views expressed are those of the authors and should not be attributed to the DST, NRF, CANSA, MRC-SA or Rhodes University. We apologize if we have inadvertently missed any important contributions to the field.
- Full Text: false
- Date Issued: 2016
- Authors: McAlpine, Shelli R , Edkins, Adrienne L
- Date: 2016
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66359 , vital:28940 , https://doi.org/10.1007/978-3-319-32607-8
- Description: publisher version , Introduction: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. , This work is based on the research supported by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa (Grant No 98566), the Cancer Association of South Africa (CANSA), Medical Research Council South Africa (MRC-SA) and Rhodes University. The views expressed are those of the authors and should not be attributed to the DST, NRF, CANSA, MRC-SA or Rhodes University. We apologize if we have inadvertently missed any important contributions to the field.
- Full Text: false
- Date Issued: 2016
Strengthening postgraduate supervision
- McKenna, Sioux, Clarence-Fincham, Jenny, Boughey, Chrissie, Wels, Harry, Van den Heuvel, Henk
- Authors: McKenna, Sioux , Clarence-Fincham, Jenny , Boughey, Chrissie , Wels, Harry , Van den Heuvel, Henk
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66645 , vital:28975 , ISBN 9781928357322 , https://doi.10.18820/9781928357323
- Description: Preface: Since 1996 the number of students enrolled for Master’s study in South Africa has more than doubled, while doctoral enrolments have almost tripled (Cloete, Mouton and Sheppard 2015). Such enormous growth has had major implications for supervision, especially in a context where only 39% of academics have doctorates themselves. If South Africa is to come close to the National Development Plan target of 5 000 doctoral graduates per year by 2030, the pressure on supervisors is likely to continue apace. But supervision is of course not simply a matter of applying technical skills to churn out highly competent postgraduate scholars. It is a teaching craft coupled with research acumen and deep personal commitment. This book reflects on how a range of supervisors are making sense of this complex endeavour. The Strengthening Postgraduate Supervision book brings together 15 chapters written by 18 academics from 16 disciplines in 11 institutions. The authors work across all three institutional types found in higher education in South Africa: traditional universities, comprehensive universities and universities of technology. Through this rich array of contributions, supervision is presented never as a ‘best practice’ to be generically implemented but rather as a nuanced pedagogy to be nurtured through critical reflection. The chapters mix theoretical considerations of the postgraduate process and personal narratives of supervision practice. Most of the authors can be described as emerging supervisors, with a few contributions from more experienced supervisors, but all have in common a deep desire to forge inclusive environments that foster meaningful postgraduate research and nurture a new generation of scholars. It is through the sharing of these academics’ concerns and constraints, competencies and celebrations that this book adds to our understanding of postgraduate supervision in South Africa.
- Full Text: false
- Date Issued: 2017
- Authors: McKenna, Sioux , Clarence-Fincham, Jenny , Boughey, Chrissie , Wels, Harry , Van den Heuvel, Henk
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66645 , vital:28975 , ISBN 9781928357322 , https://doi.10.18820/9781928357323
- Description: Preface: Since 1996 the number of students enrolled for Master’s study in South Africa has more than doubled, while doctoral enrolments have almost tripled (Cloete, Mouton and Sheppard 2015). Such enormous growth has had major implications for supervision, especially in a context where only 39% of academics have doctorates themselves. If South Africa is to come close to the National Development Plan target of 5 000 doctoral graduates per year by 2030, the pressure on supervisors is likely to continue apace. But supervision is of course not simply a matter of applying technical skills to churn out highly competent postgraduate scholars. It is a teaching craft coupled with research acumen and deep personal commitment. This book reflects on how a range of supervisors are making sense of this complex endeavour. The Strengthening Postgraduate Supervision book brings together 15 chapters written by 18 academics from 16 disciplines in 11 institutions. The authors work across all three institutional types found in higher education in South Africa: traditional universities, comprehensive universities and universities of technology. Through this rich array of contributions, supervision is presented never as a ‘best practice’ to be generically implemented but rather as a nuanced pedagogy to be nurtured through critical reflection. The chapters mix theoretical considerations of the postgraduate process and personal narratives of supervision practice. Most of the authors can be described as emerging supervisors, with a few contributions from more experienced supervisors, but all have in common a deep desire to forge inclusive environments that foster meaningful postgraduate research and nurture a new generation of scholars. It is through the sharing of these academics’ concerns and constraints, competencies and celebrations that this book adds to our understanding of postgraduate supervision in South Africa.
- Full Text: false
- Date Issued: 2017
Happiness, national pride and the 2010 World Cup
- Authors: Moller, Valerie
- Date: 2014
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67265 , vital:29065 , https://www.taylorfrancis.com/books/e/9781317664185
- Description: publisher version , The potential for national pride to take on shades of both the authentic and the hubristic is reflected in the International Social Survey Program's (ISSP) use of two different multi-item measures of national pride, a general and a domain-specific one. In contrast, domain-specific national pride is characterized as 'not overtly nationalistic, imperialistic, nor chauvinistic' and is expressed as positive feelings towards national accomplishments in a range of domains including arts, science and sport. Most scholars who take an interest in the impact of sport mega-events acknowledge that national pride is related to concepts such as patriotism and nationalism whose meanings are difficult to disentangle. The South African Social Attitudes Survey (SASAS), which has tracked the attitudes of South African adults around the 2010 World Cup, has confirmed this idea. The longitudinal SASAS study found that subsequent to the event, there was an enormous upswing in the belief that the World Cup had a positive impact on social cohesion.
- Full Text: false
- Date Issued: 2014
- Authors: Moller, Valerie
- Date: 2014
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67265 , vital:29065 , https://www.taylorfrancis.com/books/e/9781317664185
- Description: publisher version , The potential for national pride to take on shades of both the authentic and the hubristic is reflected in the International Social Survey Program's (ISSP) use of two different multi-item measures of national pride, a general and a domain-specific one. In contrast, domain-specific national pride is characterized as 'not overtly nationalistic, imperialistic, nor chauvinistic' and is expressed as positive feelings towards national accomplishments in a range of domains including arts, science and sport. Most scholars who take an interest in the impact of sport mega-events acknowledge that national pride is related to concepts such as patriotism and nationalism whose meanings are difficult to disentangle. The South African Social Attitudes Survey (SASAS), which has tracked the attitudes of South African adults around the 2010 World Cup, has confirmed this idea. The longitudinal SASAS study found that subsequent to the event, there was an enormous upswing in the belief that the World Cup had a positive impact on social cohesion.
- Full Text: false
- Date Issued: 2014
South African perceptions of the good life twenty years into democracy
- Authors: Moller, Valerie
- Date: 2016
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67215 , vital:29060 , https://doi.org/10.1007/978-3-319-20568-7_15
- Description: publisher version , South Africa celebrated 20 years of democracy in 2014. In 1994, life satisfaction among all South Africans peaked following the first open non-racial elections. Since that time, only some 45–55 % of the total population, on average, state that they are satisfied. Drawing on Alex Michalos’ classic Multiple Discrepancy Theory (MDT), this chapter explores the needs, expectations, aspirations and perceptions of progress among black South Africans, who were promised a better life under democracy by the new government they voted for in 1994. Findings suggest that expectations raised by the new government in the early years of democracy, coupled with a strong sense of entitlement to state services and welfare in later years, are among the strongest drivers of life satisfaction 20 years into democracy. South Africa’s democracy project is still a work in progress and black South Africans continue to hope for a better life in the future.
- Full Text: false
- Date Issued: 2016
- Authors: Moller, Valerie
- Date: 2016
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67215 , vital:29060 , https://doi.org/10.1007/978-3-319-20568-7_15
- Description: publisher version , South Africa celebrated 20 years of democracy in 2014. In 1994, life satisfaction among all South Africans peaked following the first open non-racial elections. Since that time, only some 45–55 % of the total population, on average, state that they are satisfied. Drawing on Alex Michalos’ classic Multiple Discrepancy Theory (MDT), this chapter explores the needs, expectations, aspirations and perceptions of progress among black South Africans, who were promised a better life under democracy by the new government they voted for in 1994. Findings suggest that expectations raised by the new government in the early years of democracy, coupled with a strong sense of entitlement to state services and welfare in later years, are among the strongest drivers of life satisfaction 20 years into democracy. South Africa’s democracy project is still a work in progress and black South Africans continue to hope for a better life in the future.
- Full Text: false
- Date Issued: 2016
South Africa, quality of life
- Moller, Valerie, Roberts, Benjamin J
- Authors: Moller, Valerie , Roberts, Benjamin J
- Date: 2014
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67255 , vital:29064 , https://doi.org/10.1007/978-94-007-0753-5
- Description: publisher version , The aim of this encyclopedia is to provide a comprehensive reference work on scientific and other scholarly research on the quality of life, including health-related quality of life research or also called patient-reported outcomes research. Since the 1960s two overlapping but fairly distinct research communities and traditions have developed concerning ideas about the quality of life, individually and collectively, one with a fairly narrow focus on health-related issues and one with a quite broad focus. In many ways, the central issues of these fields have roots extending to the observations and speculations of ancient philosophers, creating a continuous exploration by diverse explorers in diverse historic and cultural circumstances over several centuries of the qualities of human existence. What we have not had so far is a single, multidimensional reference work connecting the most salient and important contributions to the relevant fields. Entries are organized alphabetically and cover basic concepts, relatively well established facts, lawlike and causal relations, theories, methods, standardized tests, biographic entries on significant figures, organizational profiles, indicators and indexes of qualities of individuals and of communities of diverse sizes, including rural areas, towns, cities, counties, provinces, states, regions, countries and groups of countries.
- Full Text: false
- Date Issued: 2014
- Authors: Moller, Valerie , Roberts, Benjamin J
- Date: 2014
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67255 , vital:29064 , https://doi.org/10.1007/978-94-007-0753-5
- Description: publisher version , The aim of this encyclopedia is to provide a comprehensive reference work on scientific and other scholarly research on the quality of life, including health-related quality of life research or also called patient-reported outcomes research. Since the 1960s two overlapping but fairly distinct research communities and traditions have developed concerning ideas about the quality of life, individually and collectively, one with a fairly narrow focus on health-related issues and one with a quite broad focus. In many ways, the central issues of these fields have roots extending to the observations and speculations of ancient philosophers, creating a continuous exploration by diverse explorers in diverse historic and cultural circumstances over several centuries of the qualities of human existence. What we have not had so far is a single, multidimensional reference work connecting the most salient and important contributions to the relevant fields. Entries are organized alphabetically and cover basic concepts, relatively well established facts, lawlike and causal relations, theories, methods, standardized tests, biographic entries on significant figures, organizational profiles, indicators and indexes of qualities of individuals and of communities of diverse sizes, including rural areas, towns, cities, counties, provinces, states, regions, countries and groups of countries.
- Full Text: false
- Date Issued: 2014
Waiting for happiness in Africa
- Moller, Valerie, Roberts, Benjamin J, Tiliouine, Habib, Loschky, Jay
- Authors: Moller, Valerie , Roberts, Benjamin J , Tiliouine, Habib , Loschky, Jay
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67225 , vital:29061 , https://s3.amazonaws.com/sdsn-whr2017/HR17-Ch4_lr.pdf
- Description: publisher version , From Introduction: Are the people in Africa really among the least happy in the world? And if African countries do have a ‘happiness deficit’, what are the prospects of Africa achieving happiness in the near future? These are questions we shall try to address in this chapter. The World Happiness Report (WHR), published since 2012, has found that happiness is less evident in Africa than in other regions of the world. It reports Gallup World Poll (GWP) ratings of happiness, measured on the ‘ladder of life’, a scale of 0 to 10, with 10 indicating greatest happiness. On the map of the Geography of Happiness, published in an earlier World Happiness Report Update 2015, the happiest countries in the world are shaded green, the unhappiest red. Africa stands out as the unhappiest continent, being coloured almost entirely in shades of glaring red (See Fig. 4.1). In 2017, the WHR reports that average ladder scores for over four in five African countries are below the mid-point of the scale (see Fig. 4.2). And only two African countries have made significant gains in happiness over the past decade . There are also considerable inequalities in life evaluations in African countries, and this inequality in happiness has increased over the past years . In this chapter, we shall tentatively seek a number of explanations for the unhappiness on the African continent, which is home to about 16% of the world’s population. It will be no easy task to identify factors that may have shaped perceptions of well-being among the 1.2 billion African people who live in 54 nation states with different historical, cultural, and socio-economic backgrounds. Nonetheless, we shall attempt to describe some of the positive and negative experiences in the lives of people in African countries that likely impact on personal well-being. We shall also try to identify the prospects for change and development that could spell hope for increasing the happiness of African people in future.
- Full Text: false
- Date Issued: 2017
- Authors: Moller, Valerie , Roberts, Benjamin J , Tiliouine, Habib , Loschky, Jay
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67225 , vital:29061 , https://s3.amazonaws.com/sdsn-whr2017/HR17-Ch4_lr.pdf
- Description: publisher version , From Introduction: Are the people in Africa really among the least happy in the world? And if African countries do have a ‘happiness deficit’, what are the prospects of Africa achieving happiness in the near future? These are questions we shall try to address in this chapter. The World Happiness Report (WHR), published since 2012, has found that happiness is less evident in Africa than in other regions of the world. It reports Gallup World Poll (GWP) ratings of happiness, measured on the ‘ladder of life’, a scale of 0 to 10, with 10 indicating greatest happiness. On the map of the Geography of Happiness, published in an earlier World Happiness Report Update 2015, the happiest countries in the world are shaded green, the unhappiest red. Africa stands out as the unhappiest continent, being coloured almost entirely in shades of glaring red (See Fig. 4.1). In 2017, the WHR reports that average ladder scores for over four in five African countries are below the mid-point of the scale (see Fig. 4.2). And only two African countries have made significant gains in happiness over the past decade . There are also considerable inequalities in life evaluations in African countries, and this inequality in happiness has increased over the past years . In this chapter, we shall tentatively seek a number of explanations for the unhappiness on the African continent, which is home to about 16% of the world’s population. It will be no easy task to identify factors that may have shaped perceptions of well-being among the 1.2 billion African people who live in 54 nation states with different historical, cultural, and socio-economic backgrounds. Nonetheless, we shall attempt to describe some of the positive and negative experiences in the lives of people in African countries that likely impact on personal well-being. We shall also try to identify the prospects for change and development that could spell hope for increasing the happiness of African people in future.
- Full Text: false
- Date Issued: 2017
The Kenyan banking industry: Challenges and sustainability
- Muriithi, Samuel M, Louw, Lynette
- Authors: Muriithi, Samuel M , Louw, Lynette
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/69151 , vital:29433 , https://doi.org/10.1007/978-3-319-41090-6_1
- Description: This first chapter of the book aims to provide an overview of the key factors in knowledge and innovation management processes that are influencing and are influenced by the business environment in Africa. The chapter highlights the problematic of achieving a successful and sustainable business in Africa. It therefore outlines the various study programmes of cutting-edge research within different thematic areas such as innovation; entrepreneurship; education; capacity building; human capital; investment; and banking and finance. Finally, the chapter provides an executive summary of all the chapters included in the book.
- Full Text: false
- Date Issued: 2017
- Authors: Muriithi, Samuel M , Louw, Lynette
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/69151 , vital:29433 , https://doi.org/10.1007/978-3-319-41090-6_1
- Description: This first chapter of the book aims to provide an overview of the key factors in knowledge and innovation management processes that are influencing and are influenced by the business environment in Africa. The chapter highlights the problematic of achieving a successful and sustainable business in Africa. It therefore outlines the various study programmes of cutting-edge research within different thematic areas such as innovation; entrepreneurship; education; capacity building; human capital; investment; and banking and finance. Finally, the chapter provides an executive summary of all the chapters included in the book.
- Full Text: false
- Date Issued: 2017
Shadow of the Sun – the distribution of wellbeing in Sub-Saharan Africa
- Roberts, Benjamin J, Gordon, Steven Lawrence, Moller, Valerie, Struwig, Jare
- Authors: Roberts, Benjamin J , Gordon, Steven Lawrence , Moller, Valerie , Struwig, Jare
- Date: 2015
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67235 , vital:29062 , https://doi.org/10.1007/978-94-017-9178-6_23
- Description: publisher version , Despite the enthusiasm that prevailed during sub-Saharan Africa’s initial wave of independence, representations of quality of life in the region over the last half-century focused on themes that typically characterize failed states: maladministration, violence and conflict, disease, impoverishment and suffering. Although considerable hardship persists, the subcontinent experienced impressive economic growth over the last decade. This, together with increasing gains from state-led social spending, has prompted a new narrative that speaks of promise and opportunity. Against this backdrop, the chapter reviews quality of life in the region using select objective and subjective wellbeing measures. The results confirm the general pattern of recent social progress, though lingering deprivation, inequality and often difficult political conditions. While this situation is reflected in relatively low life satisfaction evaluations, it is also accompanied by a resolute optimism that attests to the resilience of the region’s citizens in the face of adversity. The chapter also assesses the influence of certain objective conditions on subjective wellbeing at the macro-level.
- Full Text: false
- Date Issued: 2015
- Authors: Roberts, Benjamin J , Gordon, Steven Lawrence , Moller, Valerie , Struwig, Jare
- Date: 2015
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67235 , vital:29062 , https://doi.org/10.1007/978-94-017-9178-6_23
- Description: publisher version , Despite the enthusiasm that prevailed during sub-Saharan Africa’s initial wave of independence, representations of quality of life in the region over the last half-century focused on themes that typically characterize failed states: maladministration, violence and conflict, disease, impoverishment and suffering. Although considerable hardship persists, the subcontinent experienced impressive economic growth over the last decade. This, together with increasing gains from state-led social spending, has prompted a new narrative that speaks of promise and opportunity. Against this backdrop, the chapter reviews quality of life in the region using select objective and subjective wellbeing measures. The results confirm the general pattern of recent social progress, though lingering deprivation, inequality and often difficult political conditions. While this situation is reflected in relatively low life satisfaction evaluations, it is also accompanied by a resolute optimism that attests to the resilience of the region’s citizens in the face of adversity. The chapter also assesses the influence of certain objective conditions on subjective wellbeing at the macro-level.
- Full Text: false
- Date Issued: 2015
Re-framing academic staff development
- Vorster, Jo-Anne, Quinn, Lynn
- Authors: Vorster, Jo-Anne , Quinn, Lynn
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66535 , vital:28960 , https://doi.org/10.1007/978-94-6300-983-6_8
- Description: publisher version , Globally higher education is situated in a supercomplex world (Barnett, 2000) that is constantly in a state of flux and subject to multiple pressures. This situation has been exacerbated in South African higher education that has been characterised by student protests in the last two years (2015–2016). One of the major causes for the recents protests, particularly in our institutional context, has been students’ anger that despite the official demise of apartheid and the end of colonial rule, some universities in South Africa are still attempting to be copies of Oxford and Harvard.
- Full Text: false
- Date Issued: 2017
- Authors: Vorster, Jo-Anne , Quinn, Lynn
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66535 , vital:28960 , https://doi.org/10.1007/978-94-6300-983-6_8
- Description: publisher version , Globally higher education is situated in a supercomplex world (Barnett, 2000) that is constantly in a state of flux and subject to multiple pressures. This situation has been exacerbated in South African higher education that has been characterised by student protests in the last two years (2015–2016). One of the major causes for the recents protests, particularly in our institutional context, has been students’ anger that despite the official demise of apartheid and the end of colonial rule, some universities in South Africa are still attempting to be copies of Oxford and Harvard.
- Full Text: false
- Date Issued: 2017