The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
- Magnus, Ashley D, Haigh, John M, Kanfer, Isadore
- Authors: Magnus, Ashley D , Haigh, John M , Kanfer, Isadore
- Date: 1981
- Language: English
- Type: Article
- Identifier: vital:6397 , http://hdl.handle.net/10962/d1006322
- Description: Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate@ (betamethasone 17-valerate, 0.1 %) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating that the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.
- Full Text:
- Authors: Magnus, Ashley D , Haigh, John M , Kanfer, Isadore
- Date: 1981
- Language: English
- Type: Article
- Identifier: vital:6397 , http://hdl.handle.net/10962/d1006322
- Description: Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate@ (betamethasone 17-valerate, 0.1 %) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating that the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.
- Full Text:
The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in biological fluids by high pressure liquid chromatography
- Gochin, Rosa, Kanfer, Isadore, Haigh, John M
- Authors: Gochin, Rosa , Kanfer, Isadore , Haigh, John M
- Date: 1981
- Language: English
- Type: text , Article
- Identifier: vital:6364 , http://hdl.handle.net/10962/d1006064
- Description: The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in serum and urine by high-performance liquid chromatography using sulphafurazole as internal standard is described. The separation was achieved on a reversed-phase column employing acetic acid-methanol as the mobile phase with spectrophotometric detection at 230 nm. Precise simultaneous quantitative analysis of the relative components has been achieved at levels of 0.1 μg/ml for both sulphamethoxazole and its N4-acetyl metabolite using 1 ml of serum or urine.
- Full Text:
- Authors: Gochin, Rosa , Kanfer, Isadore , Haigh, John M
- Date: 1981
- Language: English
- Type: text , Article
- Identifier: vital:6364 , http://hdl.handle.net/10962/d1006064
- Description: The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in serum and urine by high-performance liquid chromatography using sulphafurazole as internal standard is described. The separation was achieved on a reversed-phase column employing acetic acid-methanol as the mobile phase with spectrophotometric detection at 230 nm. Precise simultaneous quantitative analysis of the relative components has been achieved at levels of 0.1 μg/ml for both sulphamethoxazole and its N4-acetyl metabolite using 1 ml of serum or urine.
- Full Text:
The social and spatial organisation of the Greater kudu (Tragelaphus strepsiceros Pallas 1766) in the Andries Vosloo Kudu Reserve, Eastern Cape
- Authors: Allen-Rowlandson, T S
- Date: 1981
- Subjects: Greater kudu -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5614 , http://hdl.handle.net/10962/d1003120 , Greater kudu -- South Africa -- Eastern Cape
- Description: Methods of capture, marking and age determination in the field, were investigated. The density and structure of the population, individual movements and social relationships were determined. Aspects of reproduction examined included age at puberty, agespecific fecundity, calving intervals and seasonality. Temporal changes in the spatial and social organisation are discussed in relation to environmental conditions, reproduction and population structure. Factors influencing the fecundity, dynamics and grouping patterns within the population are considered.
- Full Text:
- Authors: Allen-Rowlandson, T S
- Date: 1981
- Subjects: Greater kudu -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5614 , http://hdl.handle.net/10962/d1003120 , Greater kudu -- South Africa -- Eastern Cape
- Description: Methods of capture, marking and age determination in the field, were investigated. The density and structure of the population, individual movements and social relationships were determined. Aspects of reproduction examined included age at puberty, agespecific fecundity, calving intervals and seasonality. Temporal changes in the spatial and social organisation are discussed in relation to environmental conditions, reproduction and population structure. Factors influencing the fecundity, dynamics and grouping patterns within the population are considered.
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The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids
- Authors: Kok, Eric Charl
- Date: 1981
- Subjects: Antidepressants , Steroid hormones
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3822 , http://hdl.handle.net/10962/d1005623 , Antidepressants , Steroid hormones
- Description: It has been recorded that women respond to tricyclic antidepressives with a greater incidence of anticholinergic side effects than men do, particularly women taking an exogenous source of oestrogen. The aim of this study was to investigate the influence that ethinyl oestradiol and Premarin© had on the metabolism of a number of tricyclic antidepressives, and also the influence they had on the binding ability of microsomes to imipramine. Rat hepatocyctes and microsomes were used. Detection techniques used were High Pressure Liquid Chromatography and Spectrophotometry respectively. In addition to these studies, a study of the anticholinergic activity of Nomifensine, tricyclic antidepressives and their derivatives was performed on a rat jujenum. Results conclusively showed that ethinyl oestradiol had a marked influence on the metabolism of the tricyclic antidepressives studied. Premarin© had Iittle, if any influence. However, both ethinyl oestradiol and Premarin© affected the binding of microsomes to imipramine, but ethinyl oestradiol had the greater effect. The parent compound in each case exhibited a higher pAZ value. Results indicate that a possible explanation for the increased anticholinergic side effect is due to an inhibition of the metabolism of the tricyclic antidepressives by oestrogen.
- Full Text:
- Authors: Kok, Eric Charl
- Date: 1981
- Subjects: Antidepressants , Steroid hormones
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3822 , http://hdl.handle.net/10962/d1005623 , Antidepressants , Steroid hormones
- Description: It has been recorded that women respond to tricyclic antidepressives with a greater incidence of anticholinergic side effects than men do, particularly women taking an exogenous source of oestrogen. The aim of this study was to investigate the influence that ethinyl oestradiol and Premarin© had on the metabolism of a number of tricyclic antidepressives, and also the influence they had on the binding ability of microsomes to imipramine. Rat hepatocyctes and microsomes were used. Detection techniques used were High Pressure Liquid Chromatography and Spectrophotometry respectively. In addition to these studies, a study of the anticholinergic activity of Nomifensine, tricyclic antidepressives and their derivatives was performed on a rat jujenum. Results conclusively showed that ethinyl oestradiol had a marked influence on the metabolism of the tricyclic antidepressives studied. Premarin© had Iittle, if any influence. However, both ethinyl oestradiol and Premarin© affected the binding of microsomes to imipramine, but ethinyl oestradiol had the greater effect. The parent compound in each case exhibited a higher pAZ value. Results indicate that a possible explanation for the increased anticholinergic side effect is due to an inhibition of the metabolism of the tricyclic antidepressives by oestrogen.
- Full Text:
Toast to honorary graduates : luncheon
- Authors: Henderson, Derek Scott
- Date: 1981
- Language: English
- Type: text
- Identifier: vital:7429 , http://hdl.handle.net/10962/d1018306
- Description: Rhodes University's Vice Chancellor toast to honorary graduates : luncheon 1981
- Full Text:
- Authors: Henderson, Derek Scott
- Date: 1981
- Language: English
- Type: text
- Identifier: vital:7429 , http://hdl.handle.net/10962/d1018306
- Description: Rhodes University's Vice Chancellor toast to honorary graduates : luncheon 1981
- Full Text:
Trapped identity in the novels of Dan Jacobson
- Authors: Bekker, Janine
- Date: 1981
- Subjects: Jacobson, Dan -- Criticism and interpretation , Identity (Philosophical concept) in literature
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2260 , http://hdl.handle.net/10962/d1004545 , Jacobson, Dan -- Criticism and interpretation , Identity (Philosophical concept) in literature
- Description: Dan Jacobson has written short stories, many non-fiction articles and eight novels: The Trap (1955), A Dance in The Sun (1956), The Price of Diamonds (1957), The Evidence of Love (1959), The Beginners (1966), The Rape of Tamar (1970), The Wonder-Worker (1973), and · The Confessions of Josef Baisz (1977) . The first five are all set in South Africa, though Jacobson has been living in England since 1954, i.e. since before his first novel was published. A distinct break in terms of subject matter and voice occurs after The Beginners , giving Jacobson what he calls "two rounds as a novelist. But critics recognizing this break seem not to have recognized that all eight novels are linked by certain thematic preoccupations, notably the notion of the trapped identity, which this thesis will attempt to demonstrate. On a first reading of Jacobson's work one is drawn to affirm his portrayal of the position of the white English-speaking South African, but a closer reading reveals that he does not speak as vitally to the South African situation as he seems to, or has been taken to do. Why this should be so is the second main concern of this thesis. In the first chapter the expectations underlying English literary activity in South Africa are outlined, as this is a necessary background to the discussion of Jacobson's South African novels. (Introduction, p. 4)
- Full Text:
- Authors: Bekker, Janine
- Date: 1981
- Subjects: Jacobson, Dan -- Criticism and interpretation , Identity (Philosophical concept) in literature
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2260 , http://hdl.handle.net/10962/d1004545 , Jacobson, Dan -- Criticism and interpretation , Identity (Philosophical concept) in literature
- Description: Dan Jacobson has written short stories, many non-fiction articles and eight novels: The Trap (1955), A Dance in The Sun (1956), The Price of Diamonds (1957), The Evidence of Love (1959), The Beginners (1966), The Rape of Tamar (1970), The Wonder-Worker (1973), and · The Confessions of Josef Baisz (1977) . The first five are all set in South Africa, though Jacobson has been living in England since 1954, i.e. since before his first novel was published. A distinct break in terms of subject matter and voice occurs after The Beginners , giving Jacobson what he calls "two rounds as a novelist. But critics recognizing this break seem not to have recognized that all eight novels are linked by certain thematic preoccupations, notably the notion of the trapped identity, which this thesis will attempt to demonstrate. On a first reading of Jacobson's work one is drawn to affirm his portrayal of the position of the white English-speaking South African, but a closer reading reveals that he does not speak as vitally to the South African situation as he seems to, or has been taken to do. Why this should be so is the second main concern of this thesis. In the first chapter the expectations underlying English literary activity in South Africa are outlined, as this is a necessary background to the discussion of Jacobson's South African novels. (Introduction, p. 4)
- Full Text:
Vocabulary proficiency in English of students in the primary teachers' certificate course
- Authors: Harlech-Jones, Brian Arthur
- Date: 1981
- Subjects: English language -- Study and teaching (Elementary) Vocabulary -- Study and teaching (Elementary)
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1903 , http://hdl.handle.net/10962/d1006347
- Description: This work investigates vocabulary proficiency in English of a group of students in the Primary Teacher's Certificate course. It is shown that this is the major certification course for teachers in Black education in South Africa, and, that primary school teachers are the major source of English for Black pupils for a considerable period, if not for the duration of their school education. The quality of the teachers' English thus has a major influence on that used by the pupils. In addition to the established needs for proficiency in a national and international medium such as English, it is emphasized that , with the increasing use of English as a medium of instruction, a lack of proficiency will adversely affect general scholastic achievement. The investigation proceeds by two means: (1) a series of vocabulary tests and (2) an error analysis (lexis and morphology) , based on scripts produced by the same group to whom the tests were administered. Prior to the presentation of the tests and the results and conclusions, there is a discussion of what constitutes vocabulary. This is introduced by a discussion of the dichotemy 'structure/lexis', primarily by reference to the writings on structuralism by Charles Fries - This discussion shows that the progress in vocabulary study is intimately related to the as-yet undeveloped state of investigations into the semantics of the language . There is a referenoe to the role of frequency-counts in vocabulary teaching with specific reference to Michael West's General Service List of English Words. In the absence of other prescribed standards of attainment in vocabulary, the General Service List serves as control for the tests , and is itself under examination as a possible major resource for vocabulary teaching. It is shown that structuralism has produced the instructional method known as 'audio- lingualism', which has gained wide credence, not least in the educational system through which the subjects of this study have passed. The contributions and defects of this method are discussed , with particular reference to its deleterious effect on vocabulary teaching. It is shown that vocabulary teaching becomes increasingly important in the later stages of language learning. There is reference to the current emphasis on ' commununicative' language teaching/learning, and it is shown that a major area of application is in the presentation of materials which embody an across-the-curriculum approach. The Pre- Tests are concerned only with the four major 'parts of speech ' and use only items from the General Service List ('G.S.L'). A particular feature is the development of tests based on the 'partial productivity of lexical rules' , which proved significantly effective in distinguishing between testees of high and low proficiency . The Final Tests, compiled from items which discriminated successfully in the Pre-Tests , are presented , and a Post- Final Test form of ultimately successful items is provided. There is a brief theoretical discussion of Error Analysis, and this is followed by the presentation of the categorization of lexical and morphological errors extracted from a corpus produced by the same group which provided subjects for the tests . There is comment on this categorization, which points to both the usefulness and shortcomings of such data . Amongst the conclusions and recommendations are the following: that vocabulary teaching has languished, both because of present inadequacies in semantic investigation, and because of the predominance of structuralism; that vocabulary teaching is important throughout , but particularly in the post-initial stages ; that word-counts (specifically the G. S. L.)have a valuable place in vocabulary teaching, as controls, prompts and suppliers of resource material ; that there is a wide range of proficiency amongst these subjects , even within the limits of a word-count such as the G.S.L. (the most frequent 2000 'words ' in English , with a samantic count, and related items formed by various processes) ; that this range of proficiency and the shortcomings shown are disturbing in teachers- in- training , who are also in their eleventh and twelfth years of formal instruction in English; that there is further cause for concern when it is remembered that their pupils will need English for success in a number of subjects , and will be instructed in English mainly by teachers. drawn from this group ; that there is some evidence of a relationship between vocabulary proficiency and the frequency of items in the G.S .L. (reinforcing the suggesting that the G.S .L. is a useful ' teaching tool ' ) ; that the categorization of errors shows that mastery of the · contents of the G. S. L. would , in theory , eliminate the great majority of errors attested in the categorization, and that mastery of even the most common areas of lexis and lexical formation cannot and should not be taken for granted; and that acquaintance with the contents of a word frequency-count , and with categorizations of errors , will sharpen teachers' perceptions as to the nature of their task and the directions in which vocabulary teaching should proceed.
- Full Text:
- Authors: Harlech-Jones, Brian Arthur
- Date: 1981
- Subjects: English language -- Study and teaching (Elementary) Vocabulary -- Study and teaching (Elementary)
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1903 , http://hdl.handle.net/10962/d1006347
- Description: This work investigates vocabulary proficiency in English of a group of students in the Primary Teacher's Certificate course. It is shown that this is the major certification course for teachers in Black education in South Africa, and, that primary school teachers are the major source of English for Black pupils for a considerable period, if not for the duration of their school education. The quality of the teachers' English thus has a major influence on that used by the pupils. In addition to the established needs for proficiency in a national and international medium such as English, it is emphasized that , with the increasing use of English as a medium of instruction, a lack of proficiency will adversely affect general scholastic achievement. The investigation proceeds by two means: (1) a series of vocabulary tests and (2) an error analysis (lexis and morphology) , based on scripts produced by the same group to whom the tests were administered. Prior to the presentation of the tests and the results and conclusions, there is a discussion of what constitutes vocabulary. This is introduced by a discussion of the dichotemy 'structure/lexis', primarily by reference to the writings on structuralism by Charles Fries - This discussion shows that the progress in vocabulary study is intimately related to the as-yet undeveloped state of investigations into the semantics of the language . There is a referenoe to the role of frequency-counts in vocabulary teaching with specific reference to Michael West's General Service List of English Words. In the absence of other prescribed standards of attainment in vocabulary, the General Service List serves as control for the tests , and is itself under examination as a possible major resource for vocabulary teaching. It is shown that structuralism has produced the instructional method known as 'audio- lingualism', which has gained wide credence, not least in the educational system through which the subjects of this study have passed. The contributions and defects of this method are discussed , with particular reference to its deleterious effect on vocabulary teaching. It is shown that vocabulary teaching becomes increasingly important in the later stages of language learning. There is reference to the current emphasis on ' commununicative' language teaching/learning, and it is shown that a major area of application is in the presentation of materials which embody an across-the-curriculum approach. The Pre- Tests are concerned only with the four major 'parts of speech ' and use only items from the General Service List ('G.S.L'). A particular feature is the development of tests based on the 'partial productivity of lexical rules' , which proved significantly effective in distinguishing between testees of high and low proficiency . The Final Tests, compiled from items which discriminated successfully in the Pre-Tests , are presented , and a Post- Final Test form of ultimately successful items is provided. There is a brief theoretical discussion of Error Analysis, and this is followed by the presentation of the categorization of lexical and morphological errors extracted from a corpus produced by the same group which provided subjects for the tests . There is comment on this categorization, which points to both the usefulness and shortcomings of such data . Amongst the conclusions and recommendations are the following: that vocabulary teaching has languished, both because of present inadequacies in semantic investigation, and because of the predominance of structuralism; that vocabulary teaching is important throughout , but particularly in the post-initial stages ; that word-counts (specifically the G. S. L.)have a valuable place in vocabulary teaching, as controls, prompts and suppliers of resource material ; that there is a wide range of proficiency amongst these subjects , even within the limits of a word-count such as the G.S.L. (the most frequent 2000 'words ' in English , with a samantic count, and related items formed by various processes) ; that this range of proficiency and the shortcomings shown are disturbing in teachers- in- training , who are also in their eleventh and twelfth years of formal instruction in English; that there is further cause for concern when it is remembered that their pupils will need English for success in a number of subjects , and will be instructed in English mainly by teachers. drawn from this group ; that there is some evidence of a relationship between vocabulary proficiency and the frequency of items in the G.S .L. (reinforcing the suggesting that the G.S .L. is a useful ' teaching tool ' ) ; that the categorization of errors shows that mastery of the · contents of the G. S. L. would , in theory , eliminate the great majority of errors attested in the categorization, and that mastery of even the most common areas of lexis and lexical formation cannot and should not be taken for granted; and that acquaintance with the contents of a word frequency-count , and with categorizations of errors , will sharpen teachers' perceptions as to the nature of their task and the directions in which vocabulary teaching should proceed.
- Full Text:
What literature? : inaugural lecture delivered at Rhodes University
- Authors: Van Wyk Smith, Malvern
- Date: 1981
- Language: English
- Type: Text
- Identifier: vital:676 , http://hdl.handle.net/10962/d1020745 , ISBN 0868100692
- Description: Inaugural lecture delivered at Rhodes University , Rhodes University Libraries (Digitisation)
- Full Text:
- Authors: Van Wyk Smith, Malvern
- Date: 1981
- Language: English
- Type: Text
- Identifier: vital:676 , http://hdl.handle.net/10962/d1020745 , ISBN 0868100692
- Description: Inaugural lecture delivered at Rhodes University , Rhodes University Libraries (Digitisation)
- Full Text: