Chang liver cell line as a model for Type II Diabetes in the liver and possible reversal of this condition by an indigenous medicinal plant
- Authors: Williams, Saralene Iona
- Date: 2009
- Subjects: Diabetes -- Alternative treatment , Medicinal plants , Traditional medicine , Liver -- Diseases
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10339 , http://hdl.handle.net/10948/d1016179
- Description: The incidence of Type 2 Diabetes Mellittus (T2DM) is increasing world wide. In Africa the limited access to health care and the insidious course of the disease lead to more severe illness and diabetic complications. There is a need to find alternative approaches to treatment and prevention that address the problems and needs of Africa. Sutherlandia frutescens (S.frutescens) is a traditional herbal plant with known anti-diabetic properties, the precise mechanism of action of S.frutescens is not known. In order to develop new approaches for treatment and prevention of T2DM the pathophysiology of T2DM must be understood. T2DM is the final outcome of a multi-organ disease characterized by early defects in muscle, adipocytes, hepatocytes and pancreatic β-cells. In this study the role of the liver was investigated because of its central role in glucose and lipid metabolism. It is hard to differentiate between all the influences in an in vivo model, so the aim of this study was to develop an in vitro model of T2DM in Chang liver cells and to determine if S.frutescens can reverse the state of insulin resistance in this model. Different culture media conditions were screened to identify a method that can be used as the T2DM model in Chang liver cells. Serum free medium (MCBD-201) supplemented with human diabetic serum, (2.5%-10%), high insulin concentrations (0.1μM-1μM), high fructose concentrations (1-10mM). and a combination of high insulin and high fructose was used for this screening. Chang liver cells cultured in MCBD-201 medium supplemented with 1mM fructose and 0.1μM insulin showed reduced glucose uptake and increased lipid accumulation. The effect of two S.frutescens extracts, two anti-diabetic drugs, metformin and ciglitazone, and a hypolipidemic drug ciprofibrate were determined and shown to increase glucose uptake and reduce lipid accumulation. It was postulated that exposing the cells to excess nutrients in the form of high fructose would stimulate the cells to become adipogenic and accumulate lipids, which would interfere with the glucose uptake and induce insulin resistance. Gene expression of PPARγ, PPARα, and SREBP-1 transcription factors regulating lipid metabolism was determined in Chang liver cells cultured in insulin resistance inducing medium over a 48 hour time course. The expression of PPARγ, known to stimulate adipogenesis was increased after 6, 24 and 48 hours of exposure (P(H1)<0.0001). The expression of PPARα, known to stimulate β-oxidation expression, was significantly decreased after 24 hours of exposure (P(H1)<0.0001). The presence of the plant extracts in the insulin resistance inducing media protect against this increase in adipogenesis and decrease in β-oxidation after 48 hours of exposure by increasing PPARα expression and decreasing PPARγ expression. A PCR Array was performed which identified 32 more potential molecular targets of S.frutescens. Five of the 32 targets identified with the PCR Array were validated using qRT-PCR. These genes play a role in lipid and glucose metabolism and protection against oxidative stress and inflammation. In summary a cellular model of insulin resistace in hepatocytes has been established and the capacity of S.frutescens to reverse this process has been demonstrated by acting as a dual PPARγ/α agonist. New genes have been identified in the development of insulin resistance and as targets of S.frutescens.
- Full Text:
- Date Issued: 2009
- Authors: Williams, Saralene Iona
- Date: 2009
- Subjects: Diabetes -- Alternative treatment , Medicinal plants , Traditional medicine , Liver -- Diseases
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10339 , http://hdl.handle.net/10948/d1016179
- Description: The incidence of Type 2 Diabetes Mellittus (T2DM) is increasing world wide. In Africa the limited access to health care and the insidious course of the disease lead to more severe illness and diabetic complications. There is a need to find alternative approaches to treatment and prevention that address the problems and needs of Africa. Sutherlandia frutescens (S.frutescens) is a traditional herbal plant with known anti-diabetic properties, the precise mechanism of action of S.frutescens is not known. In order to develop new approaches for treatment and prevention of T2DM the pathophysiology of T2DM must be understood. T2DM is the final outcome of a multi-organ disease characterized by early defects in muscle, adipocytes, hepatocytes and pancreatic β-cells. In this study the role of the liver was investigated because of its central role in glucose and lipid metabolism. It is hard to differentiate between all the influences in an in vivo model, so the aim of this study was to develop an in vitro model of T2DM in Chang liver cells and to determine if S.frutescens can reverse the state of insulin resistance in this model. Different culture media conditions were screened to identify a method that can be used as the T2DM model in Chang liver cells. Serum free medium (MCBD-201) supplemented with human diabetic serum, (2.5%-10%), high insulin concentrations (0.1μM-1μM), high fructose concentrations (1-10mM). and a combination of high insulin and high fructose was used for this screening. Chang liver cells cultured in MCBD-201 medium supplemented with 1mM fructose and 0.1μM insulin showed reduced glucose uptake and increased lipid accumulation. The effect of two S.frutescens extracts, two anti-diabetic drugs, metformin and ciglitazone, and a hypolipidemic drug ciprofibrate were determined and shown to increase glucose uptake and reduce lipid accumulation. It was postulated that exposing the cells to excess nutrients in the form of high fructose would stimulate the cells to become adipogenic and accumulate lipids, which would interfere with the glucose uptake and induce insulin resistance. Gene expression of PPARγ, PPARα, and SREBP-1 transcription factors regulating lipid metabolism was determined in Chang liver cells cultured in insulin resistance inducing medium over a 48 hour time course. The expression of PPARγ, known to stimulate adipogenesis was increased after 6, 24 and 48 hours of exposure (P(H1)<0.0001). The expression of PPARα, known to stimulate β-oxidation expression, was significantly decreased after 24 hours of exposure (P(H1)<0.0001). The presence of the plant extracts in the insulin resistance inducing media protect against this increase in adipogenesis and decrease in β-oxidation after 48 hours of exposure by increasing PPARα expression and decreasing PPARγ expression. A PCR Array was performed which identified 32 more potential molecular targets of S.frutescens. Five of the 32 targets identified with the PCR Array were validated using qRT-PCR. These genes play a role in lipid and glucose metabolism and protection against oxidative stress and inflammation. In summary a cellular model of insulin resistace in hepatocytes has been established and the capacity of S.frutescens to reverse this process has been demonstrated by acting as a dual PPARγ/α agonist. New genes have been identified in the development of insulin resistance and as targets of S.frutescens.
- Full Text:
- Date Issued: 2009
Regulating franchise operations in South Africa : a study of the existing legal framework with suggestions for reform.
- Authors: Woker, Tanya Ann
- Date: 2009
- Subjects: Franchise Association of Southern Africa , Franchises (Retail trade) -- Law and legislation -- South Africa , South Africa. Dept. of Trade and Industry , Common law -- South Africa , Commercial law -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3721 , http://hdl.handle.net/10962/d1015719
- Description: This thesis analyses the existing legal framework that applies to franchising in South Africa today. The study begins with an examination of the history and nature of the franchise contract, focusing particularly on the nature of the franchise relationship. This study is undertaken in order to substantiate the argument that franchising is a unique method of doing business. There is a need therefore to recognise that the franchise contract is a special contract in its own right, just like contracts of sale, lease, insurance and suretyship. The study then goes on to examine the problems which are experienced in the sector, as well as the law which must provide solutions to these problems. The research will show that in a modern commercial world the existing legal framework, especially the common law, cannot adequately deal with many of these problems. The complex relationship between franchising and competition law is also explored. A common thread that emerges from franchise disputes is the lack of protection afforded to the interests of franchisees. Franchisees tend to be at the mercy of economically stronger franchisors, hence the belief that there is a need for a stronger regulatory framework. The study then shifts to proposals for reform. In 2000 the Department of Trade and Industry (DTI) established the Franchise Steering Committee in conjunction with the Franchise Association of South Africa (FASA) to review the regulatory environment. This Committee drafted franchise legislation which aimed to bring the regulation of the sector under the control of the DTI. This legislation has not been implemented and the DTI has changed its strategy. Instead of dealing with franchising independently, franchising will fall within the scope of consumer protection legislation. Both the consumer protection legislation and the legislation proposed by the Franchise Steering Committee are thoroughly examined and explained. Shortcomings in the proposals are highlighted and an alternative approach is recommended. It is proposed that franchise-specific legislation should be introduced but that this legislation should establish a system of co-regulation between the government and the franchise sector.
- Full Text:
- Date Issued: 2009
- Authors: Woker, Tanya Ann
- Date: 2009
- Subjects: Franchise Association of Southern Africa , Franchises (Retail trade) -- Law and legislation -- South Africa , South Africa. Dept. of Trade and Industry , Common law -- South Africa , Commercial law -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3721 , http://hdl.handle.net/10962/d1015719
- Description: This thesis analyses the existing legal framework that applies to franchising in South Africa today. The study begins with an examination of the history and nature of the franchise contract, focusing particularly on the nature of the franchise relationship. This study is undertaken in order to substantiate the argument that franchising is a unique method of doing business. There is a need therefore to recognise that the franchise contract is a special contract in its own right, just like contracts of sale, lease, insurance and suretyship. The study then goes on to examine the problems which are experienced in the sector, as well as the law which must provide solutions to these problems. The research will show that in a modern commercial world the existing legal framework, especially the common law, cannot adequately deal with many of these problems. The complex relationship between franchising and competition law is also explored. A common thread that emerges from franchise disputes is the lack of protection afforded to the interests of franchisees. Franchisees tend to be at the mercy of economically stronger franchisors, hence the belief that there is a need for a stronger regulatory framework. The study then shifts to proposals for reform. In 2000 the Department of Trade and Industry (DTI) established the Franchise Steering Committee in conjunction with the Franchise Association of South Africa (FASA) to review the regulatory environment. This Committee drafted franchise legislation which aimed to bring the regulation of the sector under the control of the DTI. This legislation has not been implemented and the DTI has changed its strategy. Instead of dealing with franchising independently, franchising will fall within the scope of consumer protection legislation. Both the consumer protection legislation and the legislation proposed by the Franchise Steering Committee are thoroughly examined and explained. Shortcomings in the proposals are highlighted and an alternative approach is recommended. It is proposed that franchise-specific legislation should be introduced but that this legislation should establish a system of co-regulation between the government and the franchise sector.
- Full Text:
- Date Issued: 2009
Benchmark value chain clusters, agglomeration economies and dynamic externalities : an intergrated approach to regional economic development
- Authors: Zeelie, Eben Johannes
- Date: 2009
- Subjects: Industrial clusters , Regional economics , Regional economic disparities , Economic development , Regional planning
- Language: English
- Type: Thesis , Doctoral , DBA
- Identifier: vital:8594 , http://hdl.handle.net/10948/1086 , Industrial clusters , Regional economics , Regional economic disparities , Economic development , Regional planning
- Description: From the broad overview of the cluster literature, the proposition emerges that the manipulation of regional economic structural and cluster factor conditions within a geographically proximate region can translate into sustainable regional economic growth outcomes. As a first step in exploring this research, a theoretical framework for the conceptualisation of industry clusters was established and a methodological framework applied to statistically identify major manufacturing value chain clusters in the Eastern Cape Province. This methodology combines a strength-of-linkage measure for all pairs of supply and use sectors (as revealed in the systematic analysis of intermediate purchasing and sales patterns in the South African Final Supply and Use Tables: 2002) with the application of Ward’s hierarchical cluster algorithm to map the national benchmark value chain clusters in the South African national economy. The ensuing national value chain benchmark cluster framework was then transposed to the Eastern Cape Province to reveal cluster concentrations and gaps that exist in the value chain clusters in the province. The methodology applied in this study provides an objective and clear perspective of inter-industry linkages in the South African economy and produces more detailed and evenly distributed clusters than traditional cluster identification methodologies. Secondary linkages were determined for each of the twenty-six core value chain clusters to depict the diversity of sectors linked to the respective core clusters. In transposing the national benchmark value chain cluster framework onto the Eastern Cape Province economy, a number of distinct advantages emerge. Firstly, it reveals gaps in value chain cluster groupings that may be filled through industry recruiting or regional business development strategies. However, not all industries absent from value chain clusters in the region are equally attractive for recruitment. Henceforth, the number of direct and indirect linkages to industries absent from the Eastern Cape Province serves as a measure of their relative attractiveness when considering their recruitment into the region. vi The benchmark value chain cluster framework alone does not explain which agglomeration externalities are generated and exploited within each cluster, but it served as the overarching framework for the remainder of the research. Accordingly, the value chain cluster framework was applied to evidence whether specialisation, competition or diversity (represented by MAR, Porter and Jacobs economies respectively) is the operative mechanism in generating cluster growth in the Eastern Cape Province. Since agglomeration externalities are not directly observable, construct-valid indicators for the various externalities, as well as appropriate mechanisms to empirically assess the statistical relevance of MAR-, Porter and Jacobs economies in stimulating cluster growth, were established. This thesis added to agglomeration literature by disaggregating the standard measure of diversity externalities into two unique diversity indicators, namely supply diversity (SDiv) and use diversity (UDiv). The SDiv- and UDiv coefficients measure the degree to which a value chain cluster’s supplying/user sectoral mix at provincial level differs from that of the cluster grouping at the national level. This distinction between supply-and use diversity developed in this study firstly provides a clearer insight into the relative regional presence of supplying- and using sectors to the various value chain clusters, and secondly, serves as a useful mechanism to regional policymakers in identifying industries that may be targeted for investment into a region. Therefore, by separating the diversity into its two components, a clear distinction can be drawn between the impact of supplying- and using sectors on value chain cluster growth in a particular region. From a narrow perspective, the empirical findings validate both the Marshall Arrow Romer- (small positive impact of regional cluster concentration) and the Jacobs theory (significant positive impact of cluster supply- and use diversity on cluster growth), while it invalidates Porter’s theory (no correlation between competition and cluster performance). The positive effect size recorded between the level of value chain cluster concentration and differential growth indicates that policy makers in the Eastern Cape Province will be well advised to direct growth interventions towards larger concentrated clusters, than towards smaller, incipient value chain clusters. Additionally, vii the effectiveness of targeted inward FDI to the Eastern Cape Province may be raised by evaluating the economic impact against current value chain cluster structure, as well as the effect on the supply- and use diversities of existing value chain clusters in the province. This thesis has also illustrated that value chain clusters that are concentrated in the region, show a positive effect size with the level of supply diversity in the region. Conversely, value chain clusters that reflect high levels of competitiveness record a positive effect size with use diversity. Policy interventions aimed at raising the performance of value chain clusters typified by smaller players in a competitive environment, should therefore consider raising the respective levels of use diversity in the region. This research awakens the proposition that a reliance on a serendipitous approach to generate dynamic externalities is not sufficient, and that certain factor conditions favour the transfer of tacit knowledge between cluster members. Accordingly, this research empirically explored whether statistically significant relationships can be detected between the common cluster elements, or factor conditions, that serve as conduits for the transfer of dynamic externalities and value chain cluster growth in the Eastern Cape Province. The findings indicate that linkages with knowledge generating institutions in the Eastern Cape Province do, albeit to a relatively small extent, have an impact on value chain cluster growth, and validates the assertion that cognitive enhancing institutions contribute to cluster growth. The importance of backward and forward linkages in nurturing regional growth is signified by the moderate effect size recorded by the level of vertical linkages and total value chain cluster growth. Similarly, a moderate effect size was recorded between the level of horizontal linkages and value chain cluster growth, which shows that cooperation amongst competing firms do stimulate cluster and regional growth in the Eastern Cape Province and affirms the proposition that inter-firm linkages on both vertical- and horizontal levels stimulate cluster growth. An expectation was that the institutional framework conditions would have a significant impact on value chain cluster growth in the Eastern Cape Province. However, the empirical findings reflect that the institutional framework conditions have no statistical impact on value chain cluster growth. The study also found a moderate, positive effect size between value chain cluster size (number of employees) and growth, which shows viii that size matters in regional growth. In other words, in contrast to their European counterparts, the larger the number of employees per value chain cluster, the greater the impact on value chain cluster growth in the Eastern Cape Province.
- Full Text:
- Date Issued: 2009
- Authors: Zeelie, Eben Johannes
- Date: 2009
- Subjects: Industrial clusters , Regional economics , Regional economic disparities , Economic development , Regional planning
- Language: English
- Type: Thesis , Doctoral , DBA
- Identifier: vital:8594 , http://hdl.handle.net/10948/1086 , Industrial clusters , Regional economics , Regional economic disparities , Economic development , Regional planning
- Description: From the broad overview of the cluster literature, the proposition emerges that the manipulation of regional economic structural and cluster factor conditions within a geographically proximate region can translate into sustainable regional economic growth outcomes. As a first step in exploring this research, a theoretical framework for the conceptualisation of industry clusters was established and a methodological framework applied to statistically identify major manufacturing value chain clusters in the Eastern Cape Province. This methodology combines a strength-of-linkage measure for all pairs of supply and use sectors (as revealed in the systematic analysis of intermediate purchasing and sales patterns in the South African Final Supply and Use Tables: 2002) with the application of Ward’s hierarchical cluster algorithm to map the national benchmark value chain clusters in the South African national economy. The ensuing national value chain benchmark cluster framework was then transposed to the Eastern Cape Province to reveal cluster concentrations and gaps that exist in the value chain clusters in the province. The methodology applied in this study provides an objective and clear perspective of inter-industry linkages in the South African economy and produces more detailed and evenly distributed clusters than traditional cluster identification methodologies. Secondary linkages were determined for each of the twenty-six core value chain clusters to depict the diversity of sectors linked to the respective core clusters. In transposing the national benchmark value chain cluster framework onto the Eastern Cape Province economy, a number of distinct advantages emerge. Firstly, it reveals gaps in value chain cluster groupings that may be filled through industry recruiting or regional business development strategies. However, not all industries absent from value chain clusters in the region are equally attractive for recruitment. Henceforth, the number of direct and indirect linkages to industries absent from the Eastern Cape Province serves as a measure of their relative attractiveness when considering their recruitment into the region. vi The benchmark value chain cluster framework alone does not explain which agglomeration externalities are generated and exploited within each cluster, but it served as the overarching framework for the remainder of the research. Accordingly, the value chain cluster framework was applied to evidence whether specialisation, competition or diversity (represented by MAR, Porter and Jacobs economies respectively) is the operative mechanism in generating cluster growth in the Eastern Cape Province. Since agglomeration externalities are not directly observable, construct-valid indicators for the various externalities, as well as appropriate mechanisms to empirically assess the statistical relevance of MAR-, Porter and Jacobs economies in stimulating cluster growth, were established. This thesis added to agglomeration literature by disaggregating the standard measure of diversity externalities into two unique diversity indicators, namely supply diversity (SDiv) and use diversity (UDiv). The SDiv- and UDiv coefficients measure the degree to which a value chain cluster’s supplying/user sectoral mix at provincial level differs from that of the cluster grouping at the national level. This distinction between supply-and use diversity developed in this study firstly provides a clearer insight into the relative regional presence of supplying- and using sectors to the various value chain clusters, and secondly, serves as a useful mechanism to regional policymakers in identifying industries that may be targeted for investment into a region. Therefore, by separating the diversity into its two components, a clear distinction can be drawn between the impact of supplying- and using sectors on value chain cluster growth in a particular region. From a narrow perspective, the empirical findings validate both the Marshall Arrow Romer- (small positive impact of regional cluster concentration) and the Jacobs theory (significant positive impact of cluster supply- and use diversity on cluster growth), while it invalidates Porter’s theory (no correlation between competition and cluster performance). The positive effect size recorded between the level of value chain cluster concentration and differential growth indicates that policy makers in the Eastern Cape Province will be well advised to direct growth interventions towards larger concentrated clusters, than towards smaller, incipient value chain clusters. Additionally, vii the effectiveness of targeted inward FDI to the Eastern Cape Province may be raised by evaluating the economic impact against current value chain cluster structure, as well as the effect on the supply- and use diversities of existing value chain clusters in the province. This thesis has also illustrated that value chain clusters that are concentrated in the region, show a positive effect size with the level of supply diversity in the region. Conversely, value chain clusters that reflect high levels of competitiveness record a positive effect size with use diversity. Policy interventions aimed at raising the performance of value chain clusters typified by smaller players in a competitive environment, should therefore consider raising the respective levels of use diversity in the region. This research awakens the proposition that a reliance on a serendipitous approach to generate dynamic externalities is not sufficient, and that certain factor conditions favour the transfer of tacit knowledge between cluster members. Accordingly, this research empirically explored whether statistically significant relationships can be detected between the common cluster elements, or factor conditions, that serve as conduits for the transfer of dynamic externalities and value chain cluster growth in the Eastern Cape Province. The findings indicate that linkages with knowledge generating institutions in the Eastern Cape Province do, albeit to a relatively small extent, have an impact on value chain cluster growth, and validates the assertion that cognitive enhancing institutions contribute to cluster growth. The importance of backward and forward linkages in nurturing regional growth is signified by the moderate effect size recorded by the level of vertical linkages and total value chain cluster growth. Similarly, a moderate effect size was recorded between the level of horizontal linkages and value chain cluster growth, which shows that cooperation amongst competing firms do stimulate cluster and regional growth in the Eastern Cape Province and affirms the proposition that inter-firm linkages on both vertical- and horizontal levels stimulate cluster growth. An expectation was that the institutional framework conditions would have a significant impact on value chain cluster growth in the Eastern Cape Province. However, the empirical findings reflect that the institutional framework conditions have no statistical impact on value chain cluster growth. The study also found a moderate, positive effect size between value chain cluster size (number of employees) and growth, which shows viii that size matters in regional growth. In other words, in contrast to their European counterparts, the larger the number of employees per value chain cluster, the greater the impact on value chain cluster growth in the Eastern Cape Province.
- Full Text:
- Date Issued: 2009
Tourism policy, biodiversity conservation and management: a case study of the Kruger National Park, South Africa
- Authors: Zhou, Leocadia
- Date: 2009
- Subjects: Biodiversity conservation -- South Africa -- Kruger National Park , Ecosystem management -- South Africa -- Kruger National Park , Tourism -- Government policy -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD (Geography)
- Identifier: vital:11513 , http://hdl.handle.net/10353/174 , Biodiversity conservation -- South Africa -- Kruger National Park , Ecosystem management -- South Africa -- Kruger National Park , Tourism -- Government policy -- South Africa
- Description: The Kruger National Park (KNP) management has recently made considerable progress in enacting new policies to address biodiversity conservation and management challenges. However, the interlinkages among the new policies to support biodiversity conservation and management have not been evaluated, particularly the principles and approaches, and how these interact in terms of policy decision-making at the economic and political levels. This study seeks to evaluate the interlinkages among the new policies and how they affect one another, as an avenue to promote a more integrated and comprehensive policy implementation. These policies include the tourism policy, the elephant management policy, and the water provision policy. At policy-making level, the integration of these three policies enhances the possibilities for balancing and controlling the pressures exerted on environmental resources. At the implementation level, it offers a framework for the coordination of the interventions of the policies in space so as to recognise and capitalize on their synergies. Given the inevitably multifarious and departmentalized nature of policy formulation in the KNP, there is a need for the analysis of interlinkages amongst policies. The conceptual framework underpinning this study derives much from Briassoulis’ (2004) policy integration. The research utilizes both qualitative and quantitative research methods, and focuses on selected camp sites within the Park. The findings indicate that current procedures for tourism policy-making and implementation are weak, and little is done by way of impact assessment. This has been attributed to the lack of capacity at the KNP. The findings also reconfirm that policy-making is too fragmented. As a result, policy coordination and cooperation among park managers is weak. This study suggests that an environmental policy integration approach can lead to improved policy-making and implementation. Informed by the data collected from interviews, questionnaires and document analyses, a management framework has been developed to demonstrate how an integrated approach to Environmental Policy Integration (EPI) or management can help sustain the practice of wildlife tourism and support biodiversity conservation. It is concluded that greater realisation of integrated policy-making and implementation in the KNP can be achieved by establishing a formal coordinating office. However, a special feature of KNP policy-making is its widespread consultation system that can provide a fertile ground for enhancing EPI.
- Full Text:
- Date Issued: 2009
- Authors: Zhou, Leocadia
- Date: 2009
- Subjects: Biodiversity conservation -- South Africa -- Kruger National Park , Ecosystem management -- South Africa -- Kruger National Park , Tourism -- Government policy -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD (Geography)
- Identifier: vital:11513 , http://hdl.handle.net/10353/174 , Biodiversity conservation -- South Africa -- Kruger National Park , Ecosystem management -- South Africa -- Kruger National Park , Tourism -- Government policy -- South Africa
- Description: The Kruger National Park (KNP) management has recently made considerable progress in enacting new policies to address biodiversity conservation and management challenges. However, the interlinkages among the new policies to support biodiversity conservation and management have not been evaluated, particularly the principles and approaches, and how these interact in terms of policy decision-making at the economic and political levels. This study seeks to evaluate the interlinkages among the new policies and how they affect one another, as an avenue to promote a more integrated and comprehensive policy implementation. These policies include the tourism policy, the elephant management policy, and the water provision policy. At policy-making level, the integration of these three policies enhances the possibilities for balancing and controlling the pressures exerted on environmental resources. At the implementation level, it offers a framework for the coordination of the interventions of the policies in space so as to recognise and capitalize on their synergies. Given the inevitably multifarious and departmentalized nature of policy formulation in the KNP, there is a need for the analysis of interlinkages amongst policies. The conceptual framework underpinning this study derives much from Briassoulis’ (2004) policy integration. The research utilizes both qualitative and quantitative research methods, and focuses on selected camp sites within the Park. The findings indicate that current procedures for tourism policy-making and implementation are weak, and little is done by way of impact assessment. This has been attributed to the lack of capacity at the KNP. The findings also reconfirm that policy-making is too fragmented. As a result, policy coordination and cooperation among park managers is weak. This study suggests that an environmental policy integration approach can lead to improved policy-making and implementation. Informed by the data collected from interviews, questionnaires and document analyses, a management framework has been developed to demonstrate how an integrated approach to Environmental Policy Integration (EPI) or management can help sustain the practice of wildlife tourism and support biodiversity conservation. It is concluded that greater realisation of integrated policy-making and implementation in the KNP can be achieved by establishing a formal coordinating office. However, a special feature of KNP policy-making is its widespread consultation system that can provide a fertile ground for enhancing EPI.
- Full Text:
- Date Issued: 2009
Women in organisational management in Zimbabwe: theory and practice
- Authors: Zikhali, Whitehead
- Date: 2009
- Subjects: Businesswomen , Discrimination in employment -- Zimbabwe , Women executives -- Zimbabwe , Success in business -- Zimbabwe , Corporate culture -- Zimbabwe , Leadership -- Zimbabwe
- Language: English
- Type: Thesis , Doctoral , PhD (Social Science Dev)
- Identifier: vital:11415 , http://hdl.handle.net/10353/d1001185 , Businesswomen , Discrimination in employment -- Zimbabwe , Women executives -- Zimbabwe , Success in business -- Zimbabwe , Corporate culture -- Zimbabwe , Leadership -- Zimbabwe
- Description: The study was premised on the truism that men have historically served in higher echelons of organizational management structures and women are under-represented. The principal objective was to explore the constraints faced by women in accessing higher leadership and senior management positions in public, private and non-governmental organisations in Zimbabwe. This study adopted the triangulation method, that is, qualitative and quantitative approaches. These mixed research methods, were upgraded by the feminist research methodologies, thereby making a contribution in the field of research. The study found out that the constraints that mostly hinder women from accessing leadership and senior management positions in public, private and NGOs were cultural practices, which represent levels of power and control that in turn hinder reforms; and women's socialisation into feminised roles. The study also found out that in most organisations, most females work under male leadership, and this traditional organisational culture, needs to be deconstructed and reversed in order to achieve gender equality. The study recommended for a human centric and integrated organizational management strategy for public, private and NGOs in Zimbabwe. The adoption of a human centric and integrated management approach should aim at gender equity and reduce women's under-representation. A human centred organizational culture has to be practiced, that would create organisational ethos that guide organizational management. An integrated organizational management approach should integrate all systems and processes into one complete framework, enabling people to work as a single unit, unified by organizational goals, shared vision and common values. The system should depend on a balanced mix of the masculine and feminine attributes. The approach should put its weight towards adoption of measures to attract, advance and empower women so as to benefit from their qualifications, experience and talent in a highly competitive environment.
- Full Text:
- Date Issued: 2009
- Authors: Zikhali, Whitehead
- Date: 2009
- Subjects: Businesswomen , Discrimination in employment -- Zimbabwe , Women executives -- Zimbabwe , Success in business -- Zimbabwe , Corporate culture -- Zimbabwe , Leadership -- Zimbabwe
- Language: English
- Type: Thesis , Doctoral , PhD (Social Science Dev)
- Identifier: vital:11415 , http://hdl.handle.net/10353/d1001185 , Businesswomen , Discrimination in employment -- Zimbabwe , Women executives -- Zimbabwe , Success in business -- Zimbabwe , Corporate culture -- Zimbabwe , Leadership -- Zimbabwe
- Description: The study was premised on the truism that men have historically served in higher echelons of organizational management structures and women are under-represented. The principal objective was to explore the constraints faced by women in accessing higher leadership and senior management positions in public, private and non-governmental organisations in Zimbabwe. This study adopted the triangulation method, that is, qualitative and quantitative approaches. These mixed research methods, were upgraded by the feminist research methodologies, thereby making a contribution in the field of research. The study found out that the constraints that mostly hinder women from accessing leadership and senior management positions in public, private and NGOs were cultural practices, which represent levels of power and control that in turn hinder reforms; and women's socialisation into feminised roles. The study also found out that in most organisations, most females work under male leadership, and this traditional organisational culture, needs to be deconstructed and reversed in order to achieve gender equality. The study recommended for a human centric and integrated organizational management strategy for public, private and NGOs in Zimbabwe. The adoption of a human centric and integrated management approach should aim at gender equity and reduce women's under-representation. A human centred organizational culture has to be practiced, that would create organisational ethos that guide organizational management. An integrated organizational management approach should integrate all systems and processes into one complete framework, enabling people to work as a single unit, unified by organizational goals, shared vision and common values. The system should depend on a balanced mix of the masculine and feminine attributes. The approach should put its weight towards adoption of measures to attract, advance and empower women so as to benefit from their qualifications, experience and talent in a highly competitive environment.
- Full Text:
- Date Issued: 2009