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Title not specified

- Agatha, Sister, SCO, Hilda, Sister, HCP, Mbangeni, Veronica, Nkosi, L., Mashego, Sylvia, Composer not specified, Dargie, Dave

Morena

- Agatha, Sister, SCO, Hilda, Sister, HCP, Mbangeni, Veronica, Nkosi, L., Mashego, Sylvia, Composer not specified, Dargie, Dave

Title not specified

- Agatha, Sister, SCO, Hilda, Sister, HCP, Mbangeni, Veronica, Nkosi, L., Mashego, Sylvia, Composer not specified, Dargie, Dave

The study of the metabolism of phenylbutazone (4-butyl-1,2 -diphenylpyrazolidine - 3,5 - dione) in rats

- Alexander, Dorothy Mary

  • Authors: Alexander, Dorothy Mary
  • Date: 1978 , 2013-10-18
  • Subjects: Drugs -- Metabolism , Phenylbutazone
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:3832 , http://hdl.handle.net/10962/d1007468 , Drugs -- Metabolism , Phenylbutazone
  • Description: In this study the metabolism of the anti-arthritic drug, phenylbutazone, was investigated in female Wistar rats, and the results compared with those of other workers in this field. Two interrelated projects were undertaken. The first covered the pattern of excretion, isolation and characterisation of the metabolites and decomposition products of phenylbutazone in rats dosed post-orally with the drug. It was found that the major route of excretion was via the urine and over 50% of the administered dose was excreted in the first 24 hours by this route. A small percentage of the dose was excreted in the faeces. The following compounds were identified using chromatographic and autoradiographic techniques: p-Hydroxy derivative of phenylbutazone γ-Hydroxy derivative of phenylbutazone in both its molecular forms (ring lactone and straight chain hydroxyl) 4-Hydroxy derivative of phenylbutazone p-γ-Dihydroxy derivative of phenylbutazone p-4-Dihydroxy derivative of phenylbutazone Hydrolysable conjugates (possibly glucuronides) Water soluble non-hydrolysable conjugates. The second project dealt with the quantitation of the water insoluble compounds isolated in the initial work. Using a unique technique, combining inverse isotope dilution assay and spectrophotometric analysis, it was found that the major metabolite was the γ-hydroxy derivative of phenylbutazone, present in both its molecular forms. Oxyphenbutazone was a minor metabolite and the p-γ-dihydroxy derivative of phenylbutazone was present only in very low concentration. These results did not conform with those of previous workers in this field who reported the γ-hydroxy derivative of phenylbutazone, in one molecular form only, as the major metabolite and the dihydroxy derivative as the second metabolite with a higher concentration in the urine than oxyphenbutazone. This disparity could be due to the fact that these workers took no account of the presence of the two molecular forms of the γ-hydroxy derivative of phenylbutazone with their different polarities and different Rf values. The present study showed that the straight chain hydroxyl isomer was probably mistakenly identified as the p-γ-dihydroxy derivative of phenylbutazone. This theory is supported by the fact that the percentage dose recovered by the previous workers of the γ-hydroxy and p-γ-dihydroxy derivatives together equalled the percentage dose recovered in this study of the two molecular forms of the γ-hydroxy derivative. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
  • Full Text:
  • Date Issued: 1978

Bacterial degradation of ixodicide amitraz

- Allcock, Errol Ralph

  • Authors: Allcock, Errol Ralph
  • Date: 1978
  • Subjects: Ticks -- Control , Pesticides -- Biodegradation , Acaricides
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4081 , http://hdl.handle.net/10962/d1007473 , Ticks -- Control , Pesticides -- Biodegradation , Acaricides
  • Description: The control of ticks on cattle has long been a matter of prime importance to stock owners over most of the intensive natural grazing areas in the Southern Hemisphere. The only practical method of dealing with the cattle tick problem in the short term is by treating the infected bovine host with ixodicides i. e. by chemical control. This can be achieved by either plunging the cattle into a dip tank containing aqueous suspensions or emulsions of the ixodicide or by spraying them with dip suspensions in a spray race.
  • Full Text:
  • Date Issued: 1978

DDC326b-12.mp3

- Andrew

  • Authors: Andrew
  • Identifier: http://hdl.handle.net/10962/336553 , vital:62151
  • Description: Setswana church music workshop
  • Full Text: false
  • Date Issued: 1978

Simochromis margaretae, a new species of cichlid fish from Lake Tanganyika

- Axelrod, G S (Glen S.), Harrison, J A (James A.), Rhodes University. J.L.B. Smith Institute of Ichthyology

  • Authors: Axelrod, G S (Glen S.) , Harrison, J A (James A.) , Rhodes University. J.L.B. Smith Institute of Ichthyology
  • Date: 1978-12
  • Subjects: Simochromis margaretae , Simochromis -- Classification , Fishes -- Classification , Fishes -- Tanganyika, Lake
  • Language: English
  • Type: text , book
  • Identifier: http://hdl.handle.net/10962/69825 , vital:29585 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
  • Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 19 , A new cichlid species of the endemic Lake Tanganyikan genus Simochromis is described from four specimens from Kigoma Harbour, illustrated and compared with the other five species of the genus. The new species, S. margaretae, differs from the others in having a greater caudal peduncle depth, longer anal fin spines, and a narrower mouth. The new species further differs from its closest relative, S. marginatus, in having a greater interorbital width, greater postocular head portion, longer mouth, and shorter pectoral fin.
  • Full Text:
  • Date Issued: 1978-12

A contribution to a generic revision of Simochromis and Tropheus (Pisces : Cichlidae) - from Lake Tanganyika, with special reference to the Pharyngeal Apophysis and its taxonomic importance

- Axelrod, Glen S

  • Authors: Axelrod, Glen S
  • Date: 1978
  • Subjects: Cichlids -- Tanganyika, Lake
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5349 , http://hdl.handle.net/10962/d1007510 , Cichlids -- Tanganyika, Lake
  • Description: The purpose of this thesis is to investigate the taxonomic status of Simochromis and Tropheue. Material for the study wae collected during three visits to Lake Tanganyika in 1976-1977. Tropheus polli G. S . Axelrod 1977, was found and described, and a new species of Simochromis was found and will be described in a forthcoming paper. Nine colour varieties of Tropheus maorii and three colour varieties of Tropheus duboisi were found and described. A diagnosis and description, with colour photographs, is given using morphometries and meristics of the five species of Simochromis and four species of Tropheus. A dissection and cleaning technique tor the pharyngeal apophysis and lower pharyngeal bone is explained, together with a method for the interpretation of relative bone composition of the pharyngeal apophysis. Photographs are included. The dentition is examined, evaluated and figured. Doubt has been cast upon the taxonomic validity of the composition of the pharyngeal apophysis as an indicator of affinity at the sub familial level. This is shown by its seeming lack of functional relationship, apparent arbitrary variation, interspecific variability in Simochromis and Tropheus, and intraspecific variability in S. diagramma and T. duboisi. Thus, the apophysis cannot be considered a reliable cichlid taxonomic characteristic at any level of classification, unless its validity is Substantiated in each instance. Furthermore, it is considered very probable that the Tropheus-Simochromis species complex is a monophyletic assemblage at the genus level, on the basis of similar dentition and mouth form, which is unique in Lake Tanganyika. It is proposed on phyletic grounds that Simochromis and Tropheus be united into the one genus Tropheus, and that Tropheus be divided into the subgenera , Tropheus (Tropheus) and Tropheus (Simochromis), along the lines of its previous division in two separate genera. Characteristics supporting this division include differences in the anal and dorsal fin meristic counts noted in the original descriptions of the genera. In addition, two modifications of the dentition were found during the course of this study which are not mentioned in any previous literature. It is considered probable, that Tropheus (Tropheus) and Tropheus (Simochromis) are monophyletic sister groups within the Tropheus complex. Pseudosimochromis Nelissen 1977 is not considered to be a taxonomically valid genus on either phyletic or gradistic grounds, and is included within Tropheus (Simochromis). The lower pharyngeal bone of T . (S.) diagramma is considered to be plesiomorphic in tooth arrangement, size and shape. A preliminary worKing hypothesis is established on the basis of the conjectures made and other available information which supports the phyletic relationship suggested by Fryer and lIes (1972). An illustration is given.
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  • Date Issued: 1978

Studies on the fermentation of molasses by Clostridium acetobutylicum

- Barber, Jennifer Mary

  • Authors: Barber, Jennifer Mary
  • Date: 1978
  • Subjects: Molasses , Clostridium acetobutylicum , Fermentation
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4084 , http://hdl.handle.net/10962/d1007611 , Molasses , Clostridium acetobutylicum , Fermentation
  • Description: The bacterium Clostridium acetobutylicum produces acetone and n [subscript] - butanol from molasses in an industrial fermentation system. Although the bacterium has been cultured in liquid media it does not grow well on agar plates and requires high concentrations of hydrogen. Pretreatment of agar plates with bovine catalase improves growth on agar media. The bacteria produce an area of clearing (halo) on Potato agar plates due to butyric acid (the precursor of n [subscript]-butanol) and ß -amylase production. This characteristic will be used as a plate screening assay for the selection of high solvent producing mutants. A laboratory scale fermentation system was developed and detailed studies including pH, turbidity and cell morphology changes, and the details of solvent production were undertaken. The fermentation was optimized for mutant selection. The production of normal solvent yields by isolated clones is required for the mutant selection programme. Studies revealed that sporulation of the clones increased their solvent yield although solvent yields were still lower than normal. Efficient sporulation is therefore a prerequisite for clone fermentation. The origin of the phage infection during the factory outbreak was determined and resistant clones obtained. The presence of a bacteriocin-like toxin causing decreases in turbidity was identified during the final fermentation stage. The strain sensitivity, optimum conditions for stability as well as the kinetics of inactivation and lethality have been investigated. Preliminary characterization and purification studies indicate the proteinaceous nature of the toxin. , KMBT_363
  • Full Text:
  • Date Issued: 1978

Studies on the metabolism of SKF 525 A|

- Barber, Peter John

  • Authors: Barber, Peter John
  • Date: 1978 , 2013-10-14
  • Subjects: Drugs -- Metabolism , Cytochrome P-450
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:3835 , http://hdl.handle.net/10962/d1007591 , Drugs -- Metabolism , Cytochrome P-450
  • Description: Spectrophotometric studies have been carried out to determine the pH dependence of binding of SKF 525 A, Brietal sodium and carbon monoxide to cytochrome P-450. The optimal pH for metabolic conversion of SKF 525 A has been investigated and this agent and its major metabolite, SKF 8742 A, have been metabolised in vitro by swine and rat hepatic microsomes. A suitable gas liquid chromatography assay has been developed and used to analyse metabolic production. The effects of carbon monoxide, dithiothreitol, n-octylamine and of induction of cytochrome P-450 by phenobarbital on metabolism of SKF 525 A and SKF 8742 A have been investigated. Attempts have been made to synthesise SKF 525 AN-oxide. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
  • Full Text:
  • Date Issued: 1978

Pastoralism and the function of the pastoral in late sixteenth century english literature

- Beard, Margaret Mary

  • Authors: Beard, Margaret Mary
  • Date: 1978
  • Subjects: English literature -- Early modern, 1500-1700 -- History and criticism , Pastoral literature, English -- History and criticism
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2282 , http://hdl.handle.net/10962/d1007609 , English literature -- Early modern, 1500-1700 -- History and criticism , Pastoral literature, English -- History and criticism
  • Description: In this thesis I have made a study of certain aspects of pastoralism and the pastoral genre in late Elizabethan literature. I have done this because I felt that Elizabethan pastoral writing was, at its best, far more than just a literary exercise undertaken, as was much Continental pastoral writing, to furnish the vernacular with a genre approved by Classical precedent. The strength of Elizabethan pastoral derived from the combination of certain indigenous factors present during Elizabeth's reign, with the current interest in imitating the Classics and introducing a famous genre into the vernacular. There had always been in English literature a strong response to the natural world and this response revealed itself in pastoral writing in which the traditional naturalistic details derived from Classical sources were infused with the grace and strength of direct observation. More importantly, Elizabethan England had a monarch who was not only ideally suited through her sex and celibacy to play the leading role in a pastoral world, but who also actively encouraged and enjoyed the eulogistic sentiments native to the Renaissance pastoral. In the English attempt to imitate a favourite Renaissance version of the pastoral - the use of a pastoral framework to comment on ecclesiastical or political affairs - there was, in Tudor Protestantism, with all its internal conflicts and its vital struggle against the political and spiritual forces of the Roman church, an ideal source of material for eclogues in the style of Mantuan. Such factors ensured that Elizabethan pastoral had a significance and relevance largely lacking in the more academic products of Continental pastoralists. Preface, p. i
  • Full Text:
  • Date Issued: 1978

Nkso si nike impilo enhle

- Belebete, Jemma, Composer not specified, Dargie, Dave

The politics of administration: a study of the career of Dr D L Smit with special reference to his work in the Department of Native Affairs, 1934-1945

- Bell, M M S

  • Authors: Bell, M M S
  • Date: 1978
  • Subjects: Smit, Douglas Lainge,1885- , South Africa. Native Affairs Commission , South Africa -- Native Affairs Department , South Africa -- History -- 1909-1961
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2596 , http://hdl.handle.net/10962/d1007624 , Smit, Douglas Lainge,1885- , South Africa. Native Affairs Commission , South Africa -- Native Affairs Department , South Africa -- History -- 1909-1961
  • Description: The written history of modern South Africa is limited by the moratorium on archival material common to' all contemporary research, and the present study is intended, in part, to help fill this gap. It has a two- fold design: first, to point out some of the anomalies in the relationship between administration and policy and secondly, to show the extent to which they are interdependent in Dr. D.L. Smit ' s career. In the process, I hope to clarify and to comment on some of the mechanics involved in Native Administration.
  • Full Text:
  • Date Issued: 1978

Some aspects of the construction and implementation of error-correcting linear codes

- Booth, Geoffrey L

  • Authors: Booth, Geoffrey L
  • Date: 1978
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:20967 , http://hdl.handle.net/10962/5718
  • Description: From Conclusion: The study of error-correcting codes is now approximately 25 years old. The first known publication on the subject was in 1949 by M. Golay, who later did much research into the subject of perfect codes. It has been recently established that all the perfect codes are known. R.W. Hamming presented his perfect single-error correcting codes in 1950, in ~n article in the Bell System Technical Journal. These codes turned out to be a special case of the powerful Bose-Chaudhuri codes which were discovered around 1960. Various work has been done on the theory of minimal redundancy of codes for a given error-correcting performance, by Plotkin, Gilbert, Varshamov and others, between 1950 and 1960. The binary BCH codes were found to be so close to the theoretical bounds that, to date, no better codes have been discovered. Although the BCH codes are extremely efficient in terms of ratio of information to check digits, they are not easily, decoded with a minimal amount of apparatus. Petersen in 1961 described an algorithm for d e coding BCH codes, but this was cumbersome compared with the majority-logic methods of Massey and others. Thus the search began for codes which are easily decoded with comparatively simple apparatus. The finite geometry codes which were described by Rudolph in a 1964 thesis were examples of codes which are easily decoded 58 by a small number of steps of majority logic. The simplicial codes of Saltzer are even better in this respect, since they can be decoded by a single step of majority logic, but are rather inefficient . The applications of coding theory have changed over the years, as well. The first computers were huge circuits of relays, which were unreliable and prone to errors. Error correcting codes were required to minimise the possibility of incorrect results. As vacuum tubes and later transistorised circuits made computers more reliable, the need for sophisticated and powerful codes in the computer world diminished. Other used presented themselves however, for example the control systems of unmanned space craft. Because of the difficulty of sending and receiving messages in this case, · very powerful codes were required. Other uses were found in transmission lines and telephone exchanges. The codes considered in this dissertation have, for the most part, been block codes for use on the binary symmetric channel. There are, however, several other applications, such as codes for use on an erasure channel, where bits are corrupted so as to be unrecognizable, rather than changed. There are also codes for burst-error correction, where chennel noise is not randomly distributed, but occurs in "bursts" a few bits long. Certain cyclic codes are of application in these cases. The theory of error correcting codes has risen from virtual non-existence in 1950 to a major and sophisticated part of communication theory. Judging from the articles in journals, it promises to be the subject of a great deal of research for some years to come.
  • Full Text:
  • Date Issued: 1978

Geology of part of the central Damara belt around the Tumas River, South West Africa

- Bunting, F J L

  • Authors: Bunting, F J L
  • Date: 1978
  • Subjects: Geology -- Namibia -- Damaraland , Geology, Stratigraphic -- Namibia , Geology -- Namibia -- Tumas River Watershed , Geology -- Namibia
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5049 , http://hdl.handle.net/10962/d1009957 , Geology -- Namibia -- Damaraland , Geology, Stratigraphic -- Namibia , Geology -- Namibia -- Tumas River Watershed , Geology -- Namibia
  • Description: The investigation covering 1500 square kilometres within the central granite zone of the Damara belt, South West Africa, revealed Pre - Damara (Abbabis) basement unconformably overlain by metasediments of the Damara Supergroup. The term Leeukop member is proposed for basal metaconglomerates of the Nosib Group that immediately overlie the basement augen-gneisses. Augen-gneiss clasts are present within the Leeukop metaconglomerates. The Damara orogeny has only partly affected the Abbabis rocks of the Tumas River Inlier but further to the west the Husab suite of red granites and granite-gneisses, as field and geochemical evidence suggest, were derived syntectonically during the Damara orogeny by reactivation of the pre- Damara basement. Rõssing alaskitic granites represent late stage melts, that were also derived from Pre- Damara basement rocks during orogenesis, which accumulated post-tectonically in structural traps at the base of the Khomas Subgroup. Salem granitoids are present in synclinal structures associated with metasediments of the Khomas Subgroup and syntectonic derivation by anatexis during the Damara orogeny is suggested. In the east the differentiated Gawib granitoid stock was emplaced post- tectonically through basement rocks into the Damara metasediments. A deep seated origin is indicated by high crystallisation temperatures (>8500°) obtained from quarternary Qz-An-Ab-Or- H₂0 plots. The metamorphic grade increases westwards from medium grade to high grade. In the east, the metapelites contain andalusite, and coexisting muscovite and quartz. This indicates that temperatures of 6000° at 3,5- 4 kb pressure were attained. In the west, coexisting wollastonite and anorthite in the Khan gneisses indicate pressure- temperature conditions of 720° at 4,5-5 kb. Two tectonic events were responsible for the regional structure. An early F₁ episode produced east- west oriented overturned folds and was followed by an intense F₂ episode of isoclinal folding which is responsible for the dominant northeast - southwest regional fabric. The interference of these folds in the proximity of the underlying basement produced the complex dome and basin structures seen in the central and western parts of the area. An F₃ episode of minor importance was also recognized. The presence of continental basement rocks in this central part of the Damara belt is evidence for formation of the orogen by in-situ deformation rather than continental collision.
  • Full Text:
  • Date Issued: 1978

Genetic and bacteriophage studies on Bacteroides thetaiotaomicron and related anaerobic strains

- Burt, Sharon Joy

  • Authors: Burt, Sharon Joy
  • Date: 1978
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:20972 , http://hdl.handle.net/10962/5753
  • Description: Gram-negative obligately anaerobic bacilli were isolated from faeces on selective media. R plasmid transfer was investigated in mating experiments between 30 anaerobes and between the anaerobes and known donor and recipient E. coli strains. The transfer of R plasmids from E.coli to B.fragilis, Bacteroides spp., Fusobacterium spp. and other faecal obligate anaerobic bacteria was possible after heat treatment of the recipients at 50°C. The anaerobic exconjugants were unstable and were not able to retransfer the ampr marker. A bacteriophage, B1 , specific for the anaerobe B.thetaiotaomicron, was isolated and characterised. The properties of the phage included a variable burst size and the production of many defective phage particles without tails which were not viable. The B.thetaiotaomicron host was able to establish a phage carrier state with B1 phage. Phenol-extracted phage DNA could transfect ca2+-treated B.thetaiotaomicron cells and transfection was not limited to a particular stage in the growth cycle. An obligatory step in the transfection procedure was a 33-fold dilution in broth, allowing replication of the infected cells. Prolonged incubation of treated cells with DNA prior to dilution in broth resulted in a large decrease in phage titre. The application of this transfection system to the development of a transformation system was not successful . Conventional transformation procedures did not yield transformants, and it was not possible to transduce B.thetaiotaomicron with B1 phage. The B.thetaiotaomicron strain used was distinguished by the formation of two distinct morphological variants. Each morphological type gave rise to the other at the same frequency. Environmental conditions other than elevated temperature, had no effect on the segregation frequency. The grey colony variant was not capsulated and was sensitive to B1 phage, whereas the white colony type was encapsulated and was phage-resistant. Another feature of the B.thetaiotaomicron strain was the low incidence of mutants. A second survey of the occurrence of R plasmids in aerobic coliforms from a remote area of the Transkei and from an urban area, was undertaken. An increase in transferable antibiotic resistance was found over the last three years. It can be concluded that this was a result of the use of antibiotics among the human population, since there are no veterinary services in the area and the addition of antibiotics to animal feeds is not practised.
  • Full Text:
  • Date Issued: 1978

Nazi'nkosi

- Buthelezi., Bishop, Nyogiyoti, Joe, Mpotulo, Lambert, Dargie, Dave

Morena

- Chabangu, Angelina, Nkanyane, Joshine Maria, Sister, Baloyi, Grace, Makhathini, Eti, Composer not specified, Dargie, Dave

Ruri o tsogile, Alleluia

- Chabangu, Angelina, Music workshop participants, Dargie, Dave

Morena

- Chabangu, Angelina, Nkanyane, Joshine Maria, Sister, Baloyi, Grace, Makhathini, Eti, Composer not specified, Dargie, Dave

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