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A business model framework for mission-driven organisations

  • Authors: Thackeray, Sean Robin
  • Date: 2023-03-31
  • Subjects: Nonprofit organizations South Africa Makhanda , Business model , Sustainable development South Africa Makhanda , Resource-based view , Social responsibility of business South Africa Makhanda
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/419123 , vital:71618
  • Description: Non-profit organisations (NPOs) contribute to our society by addressing needs through value-creation activities which are normally not addressed by normal for-profit organisations. These NPOs generate their income through donations, fundraising and market activities such as the sale of products or services. However, in the pursuit of organisational sustainability, these NPOs need to ensure that their income meets their expenditure needs over the long run, to allow continuous value creation and to pursue their mission. An organisation’s business model can be visualised through a business model framework (BMF), which have been illustrated to be useful tools for organisations to test new business models, plan and coordinate activities, and to communicate how an organisations business model works to stakeholders. The use of BMFs by NPOs may be useful for similar purposes. However, a key challenge for NPOs and their management is adapting for-profit tools to be more applicable to the NPO environment. Whilst there has been some progress within the literature on adapting these for-profit business model tools to NPOs, this area of research is relatively underrepresented in the literature. The single case study method, exploratory in nature, following a deductive approach with a theoretical framework was used to evaluate the NPO Business model framework for NPOs with multiple income streams (Sanderse, 2014) appropriateness for the Centre for Biological Control (CBC), a mission-driven research organisation located within Rhodes University. The study made use of an interpretivist paradigm through the lens of resource-based theory. The contextual environment of the CBC was similar to other NPOs in that their organisational sustainability was at risk due to uncertainty about the availability of long-term funding. The CBC is actively diversifying their income streams by establishing new partnerships, which increase the capacity and resource base of the organisation to improve its flexibility in meeting current and potential funders’ needs. The NPO Business model framework for NPOs with multiple income streams was found to be a suitable BMF to visualise the holistic operations of the CBC. However, the role of governance-related matters being represented in this BMF was found to be lacking. An amended framework including governance as part of the Business model framework for NPOs with multiple income streams was developed. This improved the BMF, by allowing for further contextual insight into the CBCs business model as governance played a major role in the key activities and income-generating strategies they participate in. The role a BMF has in assisting an organisation with resource management activities was also explored. A suitable BMF, which allows for a holistic and explicit display of an organisation’s business model, would assist in determining how resources could be better managed or orchestrated to pursue different potential income-generating strategies or improve the efficiency of how resources are used in the current business model. This study contributed to business model theory by further testing the Business model framework for NPOs with multiple income streams as a tool to visualise an NPOs business model and identifying that once the governance block was added, this BMF became more suitable within the CBCs context. A minor contribution to resource based theory was the exploration of the potential roles BMFs play in resource management, which should be further investigated in line with additional research questions proposed. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2023
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  • Date Issued: 2023-03-31

No other world: the poetry of Don Maclennan

  • Authors: Robinson, Brendon Kimbale
  • Date: 2008
  • Subjects: Maclennan, Don Maclennan, Don -- Criticism and interpretation South African poetry (English) -- History and criticism
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2221 , http://hdl.handle.net/10962/d1002264
  • Description: This is a study of the poetry of Don Maclennan in four chapters. Chapter One explores the poetry's deep involvement with the immediate world, and with the being that encounters it. Chapter Two examines the corpus's mistrust of abstract thought, and its suggestions for alternative ways of intepreting (or at least approaching an interpretation of) our existential situation. Chapter Three deals with Maclennan's writing on the subject of death, while the final chapter looks at the response of the poetry to the fact of death: put simply, this is to learn to love the situation we are in, and to record our thoughts for future generations, thus reaching beyond death to share with others the necessarily unique experience of our one and only life.
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  • Date Issued: 2008

Nutrient supplementation and secondary metaolites in melanoma cells

  • Authors: Stoll, Karin Elisabeth
  • Date: 1994
  • Subjects: Vitamin C -- Therapeutic use Cancer -- Research
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:4049 , http://hdl.handle.net/10962/d1004110
  • Description: Considerable interest exists with regard to the putative therapeutic role of ascorbic acid in various conditions. A condition which has received much attention is cancer, as it is reported that ascorbic acid may be a prophylactic against cancer development. However, the actual involvement of ascorbic acid, an oxidizing/reducing agent, in the development and progression of tumours is presently a subject of much speculation. This study initially addressed the effect of ascorbic acid supplementation over a nutritional concentration range (0 - 100 μg/ml) on the in vitro growth of non-malignant LLCMK and malignant B16 cells. Ascorbic acid supplementation of these two cell types resulted in an overall decrease in the growth of both types of cells. The actual inhibitory mechanism of ascorbic acid on cell growth was not clear. Further study attempted to define and explain a mechanism responsible for this effect. Ascorbic acid has a role in the maintenance of tissue integrity and host defences, thus providing a rational basis for examining its relationship to cancer. Ascorbic acid is lcnown to be essential for the structural integrity of the intercellular matrix of the cells, the latter being a complex aqueous gel containing, amongst other compounds, fats and prostaglandins. Fats and prostaglandins have diverse effects on. membrane stability, enzyme activity and secondary messengers within cells. Hence, this study investigated the effect of ascorbic acid supplementation on certain enzymes and secondary metabolites within the cells, which had the potential to be involved in the control of cell growth. Throughout this study, emphasis was placed on the Bl6 melanoma cells as ascorbic acid supplementation did not significantly affect levels of secondary metabolites within the non-malignant LLCMK cells. Ascorbic acid supplementation of the B16 cells resulted in significant increases in adenylate cyclase activity and cyclic adenosine monophosphate levels, witb a significant decrease in Bl6 cell growth in that particular experiment. As cyclic adenosine monophosphate has a regulatory role in the cell cycle, this study suggested that the inhibitory effect of ascorbic acid supplementation on cell growth was mediated tbrough a final effect provided by the second messenger, cyclic adenosine monophosphate. However, clarification of tbe mechanism of tbe effect of ascorbic acid on adenylate cyclase activity was required. Hence, a further study investigated prostaglandin E₂ levels, as tbese affect adenylate cyclase activity. Prostaglandin E₂ levels were also found to be inversely related to Bl6 cell growth with ascorbic acid supplementation. It thus appeared tbat adenylate cyclase activity was dependent on prostaglandin E₂ levels in the B16 cells, and further study showed that tbis was indeed the case. Here, higher levels of prostaglandin E₂ supplementation of the Bl6 cells inhibited cell growth significantly and also significantly increased adenylate cyclase activity. Arachidonic acid is the precursor of prostaglandin E₂. In the presence of ascorbic acid supplementation, the percentage arachidonic acid composition of the Bl6 cells was inversely correlated with cell growth. Hence, prostaglandin E₂ levels in ascorbic acid supplemented B16 cells appeared dependent on tbe amount of precursor present. This was confirmed when Bl6 cells were supplemented with arachidonic acid. The latter had an inhibitory effect on Bl6 cell growth and also stimulated prostaglandin E₂ production. The cause of tbe inverse relationship between B16 cell growth and arachidonic acid composition with ascorbic acid supplementation was furtber investigated and found to be dependent on tbe uptake of arachidonic acid and other essential fatty acids from tbe medium. The enzymes phospholipase A₂ delta-5 and delta-6-desaturase, and elongase which could influence arachidonic acid levels were not affected to any extent by ascorbic acid supplementation and therefore did not influence the inverse relationship between B16 cell growth and arachidonic acid. Hence, it can be concluded that the effect of ascorbic acid supplementation on the BI6 cells is mediated, in part at least, by cyclic adenosine monophosphate. However, this is not the result of a direct effect of ascorbic acid supplementation. The initial effect of ascorbic acid supplementation concerns fatty acid - in particular arachidonic acid - uptake from the medium, with subsequent cascade effects On secondary metabolites, ultimately affecting the cellular levels of cyclic adenosine monophosphate.
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  • Date Issued: 1994

Quantifying crop damage by Grey crowned crane balearica regulorum regulorum and evaluating changes in crane distribution in the North Eastern Cape, South Africa

  • Authors: Van Niekerk, Mark Harry
  • Date: 2011
  • Subjects: Cranes (Birds) -- South Africa -- Eastern Cape , Cranes (Birds) -- Geographical distribution -- South Africa -- Eastern Cape , Cranes (Birds) -- Behavior -- South Africa -- Eastern Cape , Cranes (Birds) -- Food -- South Africa -- Eastern Cape , Corn -- Effect of grazing on -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5749 , http://hdl.handle.net/10962/d1005436 , Cranes (Birds) -- South Africa -- Eastern Cape , Cranes (Birds) -- Geographical distribution -- South Africa -- Eastern Cape , Cranes (Birds) -- Behavior -- South Africa -- Eastern Cape , Cranes (Birds) -- Food -- South Africa -- Eastern Cape , Corn -- Effect of grazing on -- South Africa -- Eastern Cape
  • Description: Complaints of crop damage by cranes on planted maize in the North Eastern Cape, South Africa, have been increasing since the mid-1990‘s, and in some instances severe losses have been reported. Crop damage by the Grey Crowned Crane Balearica regulorum regulorum near the town of Maclear (31º04´S 28º22´E), has been quantified over two growing seasons, and assessed relative to losses caused by foraging Cape Crows Corvus capensis and other feeding damage assumed to be caused by insects. Twelve fields were selected based on previous patterns of crop depredation. Maize seed in seven of the fields was treated with the chemical ‗Gaucho‘ and five fields were planted with untreated maize. In order to determine the source of losses, twenty quadrats (4 m x 4 m) randomly distributed within each field were visited on average every second day, for a period of up to twenty eight days. Results indicate that seed treatments do act as a deterrent to feeding by both cranes and crows, however crane damage is generally insignificant compared to other sources of damage. My study also reviewed past sightings data of the Grey Crowned Crane in an effort to determine if the conversion of former grassland to plantations in this region may have increased foraging activity in maize fields. The data did not allow for clear-cut conclusions regarding changes in distribution or population trends. Conclusions provide direct input into the management of agricultural areas by enabling landowners to take steps to mitigate crop damage. These mitigation measures may either involve the application of seed treatments, or the planting of low risk crops in high risk areas. Future studies should consider the ppossible detrimental effects of chemical seed treatments on crane biology.
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  • Date Issued: 2011

Exploring the suitability of the evaluation criteria used in the MPT projects, by looking at hard and soft components of development programmes

  • Authors: Ncapai, Wandile
  • Date: 2002
  • Subjects: Community development -- South Africa -- Eastern Cape , Community development , Economic development -- South Africa -- Eastern Cape , Economic development projects -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MSocSc
  • Identifier: vital:3397 , http://hdl.handle.net/10962/d1018255
  • Description: The study explores the suitability of the evaluation criteria used in Microprojects Programme Trust (MPT), by looking at hard and soft components of the development programme. In this sense hard components of development refer to those components of projects that are tangible and can be physically observed and can bring material changes to the life of the community. Soft components of development refer to those components of projects that bring qualitative transformation to the life of the community, i.e. increased levels of awareness, human well-being and the empowerment process that addresses the community's abstract needs, these are not tangible and often cannot be physically observed. Midway through its contract periods MPT evaluate all projects. The purpose of these mid term evaluations is to make recommendations to MPT on future approaches and methodology for community development and operations. The mid-term evaluation also influences the distribution and allocation of resources and funding. It was therefore vital that the criteria used are subject to tests and critical analysis so as to assess their validity. The assessment of the mid-term evaluation criteria used in MPT projects has been to further determine the appropriateness or suitability of the evaluation criteria as an instrument to measure and guide the MPT community development approach in the Eastern Cape. The method used was to conduct focus group discussions so as to get an insight into the local community situation as well as to assess non-tangible improvements and changes that have occurred in the life of the community as a result of the project. The information generated was used to compare what the community believe they achieved with what the official mid-term evaluation reports indicate was assessed and achieved and that was contrasted with what the literature recommends should have been assessed. The study found that the mid-term evaluations conducted on MPT projects have no social context in which the evaluations themselves were conducted. The terms of reference and criteria were based on the programme design which was formulated and compiled by the European Union without the participation of the local South African community. The findings also indicated that projects become unsuccessful or partly successful if the "soft" components which have a bearing on social and economic realities are neglected. The thesis ends with recommendations on how the mid-term evaluations as well as MPT programme can be developed to be more responsive to the needs as identified by the communities themselves. It is strongly believed that this study will provide a valuable contribution towards increasing the ability of MPT programme to bring about both material and qualitative transformation to the I ives of the disadvantaged community of the Eastern Cape whilst ensuring that the mid-term evaluations are developed and shaped to become an appropriate instrument to measure and guide MPT programme approach to community development.
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  • Date Issued: 2002

A study of the Presbyterian Church mission in the Transvaal from 1903-1960

  • Authors: Boyd, Barry Graeme
  • Date: 1981 , 2013-03-22
  • Subjects: Presbyterian Church -- South Africa -- Transvaal , Missions -- South Africa -- Transvaal
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:1226 , http://hdl.handle.net/10962/d1006110 , Presbyterian Church -- South Africa -- Transvaal , Missions -- South Africa -- Transvaal
  • Description: The aim of ·this study is to present a picture of the circumstances and the manner in which the mission was undertaken. With this in mind reference has been made to individual men and their particular importance and also to the decislons of the Church Assembly as they affected Mission. In part, the thesis is fuller for the earlier years, for the writer holds that these were the most formative as they established the pattern. Furthormore the writer wishes to make clear that the Mission become the work of black men with the white Mission Secretary of the 1950's filling an administrative role. This does not mean he was unimportant but for the nature of this study and its desire to ·emphasise the role of the black man, the work of these individual administrators has been largely omitted. In the concluding chapters the writer has shown the effects of political changes and African Nationalism on the Mission with a further chapter on the Mission's educational work. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
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  • Date Issued: 1981

Technology in conservation: towards a system for in-field drone detection of invasive vegetation

  • Authors: James, Katherine Margaret Frances
  • Date: 2020
  • Subjects: Drone aircraft in remote sensing , Neural networks (Computer science) , Drone aircraft in remote sensing -- Case studies , Machine learning , Computer vision , Environmental monitoring -- Remote sensing , Invasive plants -- Monitoring
  • Language: English
  • Type: text , Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/143408 , vital:38244
  • Description: Remote sensing can assist in monitoring the spread of invasive vegetation. The adoption of camera-carrying unmanned aerial vehicles, commonly referred to as drones, as remote sensing tools has yielded images of higher spatial resolution than traditional techniques. Drones also have the potential to interact with the environment through the delivery of bio-control or herbicide, as seen with their adoption in precision agriculture. Unlike in agricultural applications, however, invasive plants do not have a predictable position relative to each other within the environment. To facilitate the adoption of drones as an environmental monitoring and management tool, drones need to be able to intelligently distinguish between invasive and non-invasive vegetation on the fly. In this thesis, we present the augmentation of a commercially available drone with a deep machine learning model to investigate the viability of differentiating between an invasive shrub and other vegetation. As a case study, this was applied to the shrub genus Hakea, originating in Australia and invasive in several countries including South Africa. However, for this research, the methodology is important, rather than the chosen target plant. A dataset was collected using the available drone and manually annotated to facilitate the supervised training of the model. Two approaches were explored, namely, classification and semantic segmentation. For each of these, several models were trained and evaluated to find the optimal one. The chosen model was then interfaced with the drone via an Android application on a mobile device and its performance was preliminarily evaluated in the field. Based on these findings, refinements were made and thereafter a thorough field evaluation was performed to determine the best conditions for model operation. Results from the classification task show that deep learning models are capable of distinguishing between target and other shrubs in ideal candidate windows. However, classification in this manner is restricted by the proposal of such candidate windows. End-to-end image segmentation using deep learning overcomes this problem, classifying the image in a pixel-wise manner. Furthermore, the use of appropriate loss functions was found to improve model performance. Field tests show that illumination and shadow pose challenges to the model, but that good recall can be achieved when the conditions are ideal. False positive detection remains an issue that could be improved. This approach shows the potential for drones as an environmental monitoring and management tool when coupled with deep machine learning techniques and outlines potential problems that may be encountered.
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  • Date Issued: 2020

Sexual socialisation: young adult women storying how sexual activities were discussed in South African cultural contexts

  • Authors: Ludidi, Zizipho
  • Date: 2022-04-07
  • Subjects: Socialization South Africa , Sex Social aspects South Africa , Young women Socialization South Africa , Young women Sexual behavior South Africa , Culture , Memory , Narrative inquiry (Research method)
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/292737 , vital:57011
  • Description: Epidemics such as HIV/AIDS, unplanned pregnancy, gender-based violence and homophobia, in South Africa, have focused research on how young people learn about sex. This research has often focused on young girls from risk-saturated areas, and specific agents of socialisation, where they might learn about sex, such as parents, life orientation at schools, peers, media, and traditional cultural approaches. Using a narrative theoretical framework, through memory work, this study explored how black young adult women friends – who were university students – experienced forms of sexual socialisation, through various communication in South African cultural contexts. Findings from the thematic narrative analysis that was conducted demonstrated that sexual socialisation is a complex life-long process. This takes place through a collision of contradictory messages, from different agents of socialisation, in different cultural contexts. Themes were identified and organised to tell an overall sexual socialisation story that progressed through time, moving from a stage of perceived innocent oblivion, mixed messages in primary and high school, “liberal” university stories and the current stage of reauthoring stories. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
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  • Date Issued: 2022-04-07

Rhodeo, Vol. 19, No. 19

  • Subjects: Grahamstown -- Newspapers , Journalism, Students -- South Africa , Rhodes University -- Activate , Rhodes University -- Students , Student newspapers and periodicals -- South Africa
  • Language: English
  • Type: Text
  • Identifier: vital:14534 , http://hdl.handle.net/10962/d1019406
  • Description: Rhodeo is the Independent Student Newspaper of Rhodes University. Located in Grahamstown, Rhodeo was established in 1947, and renamed in 1994 as Activate. During apartheid Rhodeo became an active part of the struggle for freedom of expression as part of the now defunct South African Student Press Union. Currently Activate is committed to informing Rhodes University students, staff and community members about relevant issues, mainly on campus. These issues range from hard news to more creative journalism. While Activate acts as a news source, one of its main objectives it to be accessible as a training ground for student journalists. The newspaper is run entirely by the students and is published twice a term. Activate is a free newspaper which receives an annual grant from the Rhodes University Student Representative Council, however, majority of its revenue is generated through advertising.
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An investigation of how enquiry-based fieldwork develops action competence in Grade 12 Geography: a Namibian case study

  • Authors: Simasiku, Frederick
  • Date: 2012
  • Subjects: Competency-based education -- Namibia -- Hardap Geography -- Study and teaching (Secondary) -- Namibia -- Hardap Student-centered learning -- Namibia -- Hardap Active learning -- Namibia -- Hardap Environmental education -- Namibia -- Hardap Environmental education -- Activity programs -- Namibia -- Hardap
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1629 , http://hdl.handle.net/10962/d1003511
  • Description: The goal of the study was twofold: firstly to investigate and describe how senior secondary school geography teachers were implementing enquiry-based learning through fieldwork. Secondly, to investigate and document how enquiry-based learning through fieldwork facilitated the development of action competence amongst learners in a geography classroom. In order to address the first goal, a survey questionnaire was utilised to generate descriptive data from a sample of seven geography teachers in the Hardap region of Namibia. Although teachers engaged learners with enquiry-based fieldwork learning activities it is suggested, based on the findings of data of this goal, that teachers face severe limitations in terms of integrating environmental learning into the geography curriculum. The main limitations of the teachers include: limited practical knowledge of and training in how to teach fieldwork skills; a lack of teaching resource materials; time constraints; heavy personal loads; and lack of school support for environmental education. In addressing the second goal an enquiry-based fieldwork learning unit was planned and implemented in the researcher’s classroom. Observation, focus group interviews, and audio records of learning interactions, were used as data generation methods for this cycle of the study. An indicator framework for identifying action competence in learners was constructed as a data analysis tool. In terms of the findings of goal two it is evident that enquiry-based learning through fieldwork facilitated the development of action competence amongst learners. Six overarching benefits of this type of learning were identified in this study, namely: - It empowered learners to develop contextual knowledge and understanding of issues that they investigated. - It facilitated commitment thus motivated learners to take indirect action. - It promoted social interaction and group cohesion amongst learners thus enhanced their decision-making ability for problem-solving and action taking. - It elicited emotional responses and a greater understanding of learners’ own and others’ attitudes and values towards issues. - It fostered critical thinking thus permitted learners to envisage a future based on their learning experiences. - It enabled learners to plan and take indirect action during the learning process. Based on the research findings, some lessons learned are presented in an attempt to contribute to the effective implementation of enquiry-based fieldwork at the classroom level.
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  • Date Issued: 2012

Message from the Vice-Chancellor for the Arts and Science festival 1981

  • Authors: Henderson, Derek Scott
  • Date: 1981-05-26
  • Language: English
  • Type: Text
  • Identifier: vital:7431 , http://hdl.handle.net/10962/d1018308
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  • Date Issued: 1981-05-26

An investigation of enabling and constraining factors affecting the supply and demand of specific biodiversity scarce skills to the biodiversity sector

  • Authors: Mckrill, Leanne Joy
  • Date: 2015
  • Subjects: Rhodes University , GreenMatter (South Africa) , CATHSSETA (South Africa) , Labor demand -- South Africa , Biodiversity conservation -- Employees -- Supply and demand -- South Africa , Wildlife veterinarians -- Supply and demand -- South Africa , Freshwater ecology -- Employees -- Supply and demand -- South Africa
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:2067 , http://hdl.handle.net/10962/d1020837
  • Description: This study is situated within the context of the emerging South African Biodiversity Sector and focuses on the supply of and demand for scarce skilled biodiversity professionals. It does so through investigating the transition a young biodiversity professional makes from a higher education institution to the workplace by drawing attention to the factors encountered or perceived to be encountered during this development. The study forms part of a research programme established between Rhodes University, GreenMatter and the Culture Arts Tourism Hospitality Sport Education and Training Authority (CATHSSETA), which seeks to contribute to the body of knowledge pertaining to "green" skills development and retention within the South African biodiversity sector. It is a qualitative study, comprising nested case studies within two larger case studies of scarce skills – those of wildlife veterinarians and freshwater ecologists – as identified by the biodiversity priority scarce skills list (SANBI & Lewis Foundation, 2012). The study is supported by Bronfenbrenner's (1979) Ecological Systems theory and underpinned by the principles of basic critical realism and emergence (Archer, Bhaskar, Collier, Lawson, & Norrie, 1998). Data was generated through a range of data collection methods, including semi-structured interviews, participant observation and document analysis. The aim of these methods was to enable a greater understanding of the factors influencing transitioning and the unique transitions of selected individuals. Findings revealed that the transitions of the participants, although unique to each of them, included the following commonalities: exposure to biodiversity at an early stage in an individual's life paved the way for the development and nurturing of an interest or passion in biodiversity; experience gained prior to entry into the workplace is a powerful enabling factor; the presence or absence of a mentor can be pivotal in the transition of an individual; the gap in knowledge pertaining to demand side or workplace information is a large constraining factor; workplace dynamics affect the demand for, and eventual supply of, biodiversity professionals; the presence of human capital development strategies and structures is beneficial to the individual's transition, and the overall ecosystemic development of an individual has an effect on the supply of specific scarce-skilled individuals to the workforce. This study demonstrates that through the employment of nested case studies, similar research focussing on other scarce skills within the biodiversity sector, as per the GreenMatter Priority Skills List of 2012, can be produced, which would help to address the knowledge gaps pertaining to scarce skills, as indicated by the Biodiversity Human Capital Development Strategy (2010).
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  • Date Issued: 2015

Synthesis of silver nanoparticles and their role against a thiazolekinase enzyme from Plasmodium falciparum

  • Authors: Yao, Jia
  • Date: 2014
  • Subjects: Silver , Nanoparticles , Thiazoles , Plasmodium falciparum , Antimalarials , Malaria -- Chemotherapy
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4168 , http://hdl.handle.net/10962/d1020894
  • Description: Malaria, a mosquito-borne infectious disease, caused by the protozoan Plasmodium genus, is the greatest health challenges worldwide. The plasmodial vitamin B1 biosynthetic enzyme PfThzK diverges significantly, both structurally and functionally from its counterpart in higher eukaryotes, thereby making it particularly attractive as a biomedical target. In the present study, PfThzK was recombinantly produced as 6×His fusion protein in E. coli BL21, purified using nickel affinity chromatography and size exclusion chromatography resulting in 1.03% yield and specific activity 0.28 U/mg. The enzyme was found to be a monomer with a molecular mass of 34 kDa. Characterization of the PfThzK showed an optimum temperature and pH of 37°C and 7.5 respectively, and it is relatively stable (t₁/₂=2.66 h). Ag nanoparticles were synthesized by NaBH₄/tannic acid, and characterized by UV-vis spectroscopy and transmission electron microscopy. The morphologies of these Ag nanoparticles (in terms of size) synthesized by tannic acid appeared to be more controlled with the size of 7.06±2.41 nm, compared with those synthesized by NaBH₄, with the sized of 12.9±4.21 nm. The purified PfThzK was challenged with Ag NPs synthesized by tannic acid, and the results suggested that they competitively inhibited PfThzK (89 %) at low concentrations (5-10 μM) with a Ki = 6.45 μM.
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  • Date Issued: 2014

Rhodes University Graduation Ceremony 1977

  • Authors: Rhodes University
  • Date: 1977
  • Subjects: MacKenzie, Ian
  • Language: English
  • Type: text
  • Identifier: vital:8111 , http://hdl.handle.net/10962/d1004567 , MacKenzie, Ian
  • Description: Rhodes University Graduation Ceremonies on Friday, 1st April, 1977 at 8 p.m. [and] on Saturday, 2nd April, 1977 at 10:30 a.m.in the 1820 Settlers National Monument. , The Order for the Installation of Ian MacKenzie as Chancellor of Rhodes University within the Great Hall on Thursday 31 March 1977 at 8:15 p.m.
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  • Date Issued: 1977

The impact of good news and bad news on South Africa’s sectoral stock return volatility: an asymmetric GARCH analysis

  • Authors: Muzinda, Edmond Toreva
  • Date: 2017
  • Language: English
  • Type: Thesis , Masters , MCom
  • Identifier: http://hdl.handle.net/10962/6425 , vital:21108
  • Description: This study explores the impact of good news and bad news on South Africa’s sectoral stock return volatility using an asymmetric GARCH analysis. Understanding the different impact of news on stock return volatility in different economic sectors has important implications for investors’ risk management practices, portfolio allocation strategies and asset pricing. The study employs data of daily closing prices for nine sectors and three benchmark indices for the period 2nd January 1997 - 17th August 2016. The data was split into sub-samples of pre-, during and post-global financial crisis, as well as the overall sample period. The incorporation of sub-samples was to help explain the outcomes of the overall sample period. To capture the different impact of good news and bad news on stock return volatility for each sector, asymmetric GARCH models namely, TGARCH and EGARCH were employed. The findings from this study revealed that volatility asymmetry was present in all sectors and benchmark indices of South African equity market. Bad news had more impact on stock return volatility for all sectors except the Oil and Gas sector, than good news of the same magnitude. In the Oil and Gas sector, good news was found to have an amplified effect on return volatility compared with bad news of the same magnitude. High volatility persistence was also found to be present in the Consumer goods, Financials, Industrials, All-share index and Mid-cap index. High differential impact of good and bad news were found in the Industrials, Financials, Basic materials, Consumer goods and the All-share index. Since the main objective of this study was to provide explanations of volatility asymmetry found in the South African sectors, the following were proposed as possible explanations of the findings. Within sectors, volatility asymmetry was explained by financial leverage, the role of the media, loss-averse investors and the behaviour of traders (overconfidence and extrapolation bias). Volatility asymmetry across sectors was explained by information flow, the uneven distribution of information by the media, investor sentiments, investor expectations and trading volumes. Overall, the results indicate that the stock return volatility of individual sectors of the South African equity market is driven mainly by bad news (except for Oil and Gas) and that leverage effects exist in all the sectors and in the benchmark indices.
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  • Date Issued: 2017

Between drones and al-Shabaab: United States extra-judicial killings in Somalia, sovereignty and the future of liberal intervention

  • Authors: Koloko, Mojalefa
  • Date: 2019
  • Subjects: Somalia -- Politics and government -- 1991- , Somalia -- History -- 1991- , Somalia -- Foreign relations -- United States , Somalia -- Foreign relations -- 1991- , Military assistance, American -- Somalia , Extrajudicial exeutions -- Somalia , Shabaab (Organization)
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: http://hdl.handle.net/10962/67657 , vital:29125
  • Description: This study examines the nature of the United States intervention in Somalia, specifically the use of drone strikes that first targeted the militant Sunni Islamist transnational group, al-Qaeda, which claimed responsibility for the 11 September 2001 attacks on the United States, and now target the Somali organisation, Harakat al-Shabaab al-Mujahidin, commonly known as al-Shabaab. The use of drone strikes in the US led war on terror has raised concerns about sovereignty as the extra-judicial killings are conducted without the consent of the concerned states. Furthermore, drone strikes also raise questions about the processes of liberal intervention as the US conducts them without the approval of the United Nations Security Council. It is argued in this study that what is understood to be the “golden era” of liberal interventionism is a legacy of the post-Cold War unipolar dominance of the United States in global governance and security. It is argued that US unipolarity was accompanied by a shifting perception regarding the security position of weak states, whose weakness becomes understood as a source of global insecurity. This perception that so called “weak” and “fragile” states are sources of threats is a departure in International Relations theory, because the discipline is historically preoccupied with studying the actions of powerful states and their consequence for the global order. It is argued that the discourse on the war on terror, and its focus on “failed states” as breeding grounds for alleged terrorists, represents the height of the repositioning of less powerful states from a peripheral status in IR analysis and practice, to their current position that are now being represented as core sources of threat to international peace and security. Through life history interviews with Somali nationals in Grahamstown, Port Elizabeth and Uitenhage, South Africa, the study examines the consequences of US actions from the eyes of Somali people. The findings of this study show that despite all the controversy surrounding the legitimacy of the war on terror, the manner in which it is conducted, as well as the tactics that it employs, the majority of Somali participants showed an overwhelming support for the US intervention. Participants expressed support for the US extra-judicial killings because they are understood to undermine al-Shabaab strength which is a major source of insecurity. The study also shows that the lack of necessary collaboration between the US intelligence and the Somali ground forces has resulted in high numbers of civilian deaths, which participants fear can be used by al-Shabaab to recruit and radicalise more Somalis. The study also shows that most Somalis resent the presence of the African Union Mission in Somalia because Kenya and Ethiopia are seen as 10 pursuing national interests that are not invested in Somali peace and stability. The study concludes that US extra-judicial killings have failed to constrain the actions of al-Shabaab. Somalis expressed that the leadership of current president, Mohamed Abdullahi Mohamed Farmaajo, holds the unique possibilities of creating national unity that rises above clan divisions and the radical Jihadist ideology of al-Shabaab.
  • Full Text:
  • Date Issued: 2019

Rhodeo: 1990 - May

  • Date: 1990-05-01
  • Subjects: Grahamstown -- Newspapers , Journalism, Students -- South Africa , Rhodes University -- Activate , Rhodes University -- Students , Student newspapers and periodicals -- South Africa
  • Language: English
  • Type: Text
  • Identifier: vital:14758 , http://hdl.handle.net/10962/d1019630
  • Description: Rhodeo is the Independent Student Newspaper of Rhodes University. Located in Grahamstown, Rhodeo was established in 1947, and renamed in 1994 as Activate. During apartheid Rhodeo became an active part of the struggle for freedom of expression as part of the now defunct South African Student Press Union. Currently Activate is committed to informing Rhodes University students, staff and community members about relevant issues, mainly on campus. These issues range from hard news to more creative journalism. While Activate acts as a news source, one of its main objectives it to be accessible as a training ground for student journalists. The newspaper is run entirely by the students and is published twice a term. Activate is a free newspaper which receives an annual grant from the Rhodes University Student Representative Council, however, majority of its revenue is generated through advertising.
  • Full Text:
  • Date Issued: 1990-05-01

A constructivist deconstruction of post-apartheid South Africa’s trade negotiation strategies: the politics of development and global value chains

  • Authors: Pillay, Morgenie
  • Date: 2015
  • Language: English
  • Type: text , Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10962/64731 , vital:28596
  • Description: Expected release date-May 2020
  • Full Text:
  • Date Issued: 2015

Rhodes University Graduation Ceremony 1959

  • Authors: Rhodes University
  • Date: 1959
  • Language: English
  • Type: text
  • Identifier: vital:8093 , http://hdl.handle.net/10962/d1004403
  • Description: Rhodes University Graduation Ceremony in the University Great Hall on Friday , 3rd April, 1959, at 8 p.m. [and] Graduation Ceremony held in April 1959: University College of Fort Hare. Graduation Ceremony at Fort Hare on Friday, April 17th, 1959.
  • Full Text:
  • Date Issued: 1959

Rhodeo: 1986 - August

  • Date: 1986-08
  • Subjects: Grahamstown -- Newspapers , Journalism, Students -- South Africa , Rhodes University -- Activate , Rhodes University -- Students , Student newspapers and periodicals -- South Africa
  • Language: English
  • Type: Text
  • Identifier: vital:14742 , http://hdl.handle.net/10962/d1019614
  • Description: Rhodeo is the Independent Student Newspaper of Rhodes University. Located in Grahamstown, Rhodeo was established in 1947, and renamed in 1994 as Activate. During apartheid Rhodeo became an active part of the struggle for freedom of expression as part of the now defunct South African Student Press Union. Currently Activate is committed to informing Rhodes University students, staff and community members about relevant issues, mainly on campus. These issues range from hard news to more creative journalism. While Activate acts as a news source, one of its main objectives it to be accessible as a training ground for student journalists. The newspaper is run entirely by the students and is published twice a term. Activate is a free newspaper which receives an annual grant from the Rhodes University Student Representative Council, however, majority of its revenue is generated through advertising.
  • Full Text:
  • Date Issued: 1986-08
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