- Title
- Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks
- Creator
- Melamane, Siyabonga, Walker, Roderick B, Khamanga, Sandile M
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183265
- Identifier
- vital:43936
- Identifier
- xlink:href="https://doi.org/10.1080/03639045.2020.1791163"
- Description
- The aim of this research was to develop lamotrigine containing thermosetting hydrogel for intranasal administration to manage and treat generalized epilepsy. Thermosetting hydrogels were prepared using different ratios of poloxamer 407 (L127), poloxamer 188 (L68) and CarbopolVR 974 P NF (C974) using the cold production process. The in situ thermosetting hydrogel was optimized using Box Behken design. Co-solvency approach was used to increase the solubility of lamotrigine by dissolving it in propylene glycol and polyethylene glycol 400 (0.2: 0.8) and the resultant solution was incorporated in the hydrogel to manufacture an LTG hydrogel. The presence of a higher amount of L127 resulted in higher viscosity at 22 0C and 34 0C and decreased the overall release of LTG. An increase in the amount of C974 resulted in a decrease in the pH of the hydrogel. The results show that formulations F10, F12, F13, F14, F15, F16 and F17 exhibited acceptable thermosetting behavior, pH and released adequate Lamotrigine above the minimum effective concentration to treat generalized epilepsy. The optimized formulation exhibited acceptable thermosetting behavior, pH and lamotrigine release but formed a stiff gel at 22 0C. The average LTG content of the optimized hydrogel was 5.00 ± 0.0225mg/ml with % recovery of 99.17%. The amount of LTG released at 12 h from the optimized hydrogel was 3.21 ± 0.0155mg and will be therapeutically effective in the brain after absorption via the olfactory region in the nasal cavity.
- Format
- computer, online resource, application/pdf, 1 online resource (15 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Drug Development and Industrial Pharmacy, Melamane, S., Walker, R.B. and Khamanga, S.M., 2020. Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks. Drug Development and Industrial Pharmacy, 46(9), pp.1402-1415, Drug Development and Industrial Pharmacy volume 46 number 9 p. 1402 2020 1520-5762
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
- Hits: 965
- Visitors: 1227
- Downloads: 283
Collections
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
Khamanga, Sandile S M (Assoc Prof)
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks.pdf | 2 MB | Adobe Acrobat PDF | View Details Download |