Evaluation of water quality, selected metals and endocrine-disrupting compounds in the rivers and municipal wastewaters of Eastern Cape province, South Africa
- Authors: Farounbi, Adebayo Ibikunle
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/177327 , vital:42810
- Description: Thesis embargoed. Release date April 2022. , Thesis (PhD) -- Faculty of Science, Institute of Water Research, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Farounbi, Adebayo Ibikunle
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/177327 , vital:42810
- Description: Thesis embargoed. Release date April 2022. , Thesis (PhD) -- Faculty of Science, Institute of Water Research, 2021
- Full Text:
- Date Issued: 2021-04
The classification of fuzzy subgroups of some finite non-cyclic abelian p- groups of rank 3, with emphasis on the number of distinct fuzzy subgroups
- Authors: Appiah, Isaac Kwadwo
- Date: 2021-03
- Subjects: Fuzzy sets , Commutative algebra
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/20783 , vital:46563
- Description: In [6] and [7] we classi_ed fuzzy subgroups of some rank-3 abelian groups of the form G = Zpn + Zp + Zp for any _xed prime integer p and any positive integer n, using the natural equivalence relation de_ned in [40]. In this thesis, we extend our classi_cation of fuzzy subgroups in [6] to the group G = Zpn + Zpm + Zp for any _xed prime integer p; m = 2 and any positive integer n using the same natural equivalence relation studied in [40]. We present and prove explicit polynomial formulae for the number of (i) subgroups, (ii) maximal chains of subgroups of G for any n;m _ 2 and (iii) distinct fuzzy subgroups for m = 2 and n _ 2. We have also developed user-friendly polynomial formulae for the number of (iv) subgroups, (v) maximal chains for the group G = Zpn + Zpm for any n;m _ 2; any _xed prime positive integer p and (vi) distinct fuzzy subgroups of Zpn + Zpm for m equal to 2 and 3, and n _ 2 and provided their proofs. , Thesis (PhD) -- Faculty of Science and Agriculture, 2021
- Full Text:
- Date Issued: 2021-03
- Authors: Appiah, Isaac Kwadwo
- Date: 2021-03
- Subjects: Fuzzy sets , Commutative algebra
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/20783 , vital:46563
- Description: In [6] and [7] we classi_ed fuzzy subgroups of some rank-3 abelian groups of the form G = Zpn + Zp + Zp for any _xed prime integer p and any positive integer n, using the natural equivalence relation de_ned in [40]. In this thesis, we extend our classi_cation of fuzzy subgroups in [6] to the group G = Zpn + Zpm + Zp for any _xed prime integer p; m = 2 and any positive integer n using the same natural equivalence relation studied in [40]. We present and prove explicit polynomial formulae for the number of (i) subgroups, (ii) maximal chains of subgroups of G for any n;m _ 2 and (iii) distinct fuzzy subgroups for m = 2 and n _ 2. We have also developed user-friendly polynomial formulae for the number of (iv) subgroups, (v) maximal chains for the group G = Zpn + Zpm for any n;m _ 2; any _xed prime positive integer p and (vi) distinct fuzzy subgroups of Zpn + Zpm for m equal to 2 and 3, and n _ 2 and provided their proofs. , Thesis (PhD) -- Faculty of Science and Agriculture, 2021
- Full Text:
- Date Issued: 2021-03
Synthesis of peptidomimetic compounds as HIV-1 protease inhibitors
- Authors: Kayembe, Jean-Pierre
- Date: 2020
- Subjects: Protease inhibitors , HIV (Viruses) , HIV infections Treatment , Peptidomimetics
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/124397 , vital:35604 , DOI https://dx.doi.org/10.21504/10962/124397
- Description: This research project has involved the design, synthesis and evaluation of novel peptidomimetics compounds as HIV-1 protease inhibitors. Here is presented one-step, two-step and three-step syntheses and the in vitro bio-assay studies of a series of fully characterized peptidomimetics as HIV-1 protease inhibitors candidate using the shortest and most cost effective synthetic routes. The first series of compounds were accessed via a synthetic elaboration of Morita-Baylis-Hillman adducts by a Michael addition with benzylamine, proline or glycine esters to afford a series of β-amino-β’-hydroxycarboxylate esters in moderate to good yields. Base-catalyzed cyclization of non-benzylated aza-Michael adducts afforded a series of coumarin-3-hydroxy-2-methylenepropanoate esters in moderate yields. The uncatalyzed direct amidation of diethyl tartrate/tartaric acid and tartaric acid osazone with selected amines/amino acids afforded a series of C2-symmetrical and unsymmetrical 1,2-dihydroxycarboxylates in moderate to very high yields. All the synthesized compounds were fully characterized using spectroscopic techniques. These conjugates, designed as potential HIV-1 inhibitors, were tested against the HIV-1 protease enzyme. A number of these ligands have exhibited inhibition levels and IC50 values comparable to ritonavir, permitting, therefore, their identification as lead compounds for the development of novel inhibitors. , Thesis (PhD) -- Faculty of Science, Chemistry, 2020
- Full Text: false
- Date Issued: 2020
- Authors: Kayembe, Jean-Pierre
- Date: 2020
- Subjects: Protease inhibitors , HIV (Viruses) , HIV infections Treatment , Peptidomimetics
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/124397 , vital:35604 , DOI https://dx.doi.org/10.21504/10962/124397
- Description: This research project has involved the design, synthesis and evaluation of novel peptidomimetics compounds as HIV-1 protease inhibitors. Here is presented one-step, two-step and three-step syntheses and the in vitro bio-assay studies of a series of fully characterized peptidomimetics as HIV-1 protease inhibitors candidate using the shortest and most cost effective synthetic routes. The first series of compounds were accessed via a synthetic elaboration of Morita-Baylis-Hillman adducts by a Michael addition with benzylamine, proline or glycine esters to afford a series of β-amino-β’-hydroxycarboxylate esters in moderate to good yields. Base-catalyzed cyclization of non-benzylated aza-Michael adducts afforded a series of coumarin-3-hydroxy-2-methylenepropanoate esters in moderate yields. The uncatalyzed direct amidation of diethyl tartrate/tartaric acid and tartaric acid osazone with selected amines/amino acids afforded a series of C2-symmetrical and unsymmetrical 1,2-dihydroxycarboxylates in moderate to very high yields. All the synthesized compounds were fully characterized using spectroscopic techniques. These conjugates, designed as potential HIV-1 inhibitors, were tested against the HIV-1 protease enzyme. A number of these ligands have exhibited inhibition levels and IC50 values comparable to ritonavir, permitting, therefore, their identification as lead compounds for the development of novel inhibitors. , Thesis (PhD) -- Faculty of Science, Chemistry, 2020
- Full Text: false
- Date Issued: 2020
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