The influence of technology factors on turnover intentions amongst a sample of government employees in the Eastern Cape, South Africa
- Authors: Mahlasela, Samkelisiwe
- Date: 2018
- Subjects: Work -- Technological innovations
- Language: English
- Type: Thesis , Masters , MCom (Industrial Psychology)
- Identifier: http://hdl.handle.net/10353/13535 , vital:39677
- Description: Orientation: Technology affects organisations both positively and negatively and in some instances technology factors can result in turnover intentions for certain employees of organisations. Research purpose: The main objective of the study was to investigate how technology-based job autonomy, technology-based job overload and technologybased job monitoring impact turnover intentions of employees. Motivation of the study: Exploring and understanding the relationship between technology factors and turnover intention amongst government employees to determine whether these factors affect government as much as they affect the private sector. Research design, approach and method: This research used a quantitative research approach. It drew a convenience sample of 182 employees (N= 182) from the South African Government. Main findings: The three main findings of the study were: Technology-based job autonomy was positively related to turnover intention. Technology-based job overload was found to be positively related to turnover intention. Finally, technology-based monitoring was found to be positively related to turnover intention. Practical/managerial implications: If organisations do not address the issue of monitoring and overload they are likely to experience many turnover intentions amongst the employees. Furthermore, the organisations with less autonomy are likely to lose their employees which means they will lose the resources that have been serving the organisation for a long time. This will also contribute to the organisation losing many funds as they would constantly have to train new employees. Contribution/value-add: The research adds value to the knowledge about the effects of technology factors on turnover intention by pointing out the reasons that lead to turnover intention.
- Full Text:
- Date Issued: 2018
- Authors: Mahlasela, Samkelisiwe
- Date: 2018
- Subjects: Work -- Technological innovations
- Language: English
- Type: Thesis , Masters , MCom (Industrial Psychology)
- Identifier: http://hdl.handle.net/10353/13535 , vital:39677
- Description: Orientation: Technology affects organisations both positively and negatively and in some instances technology factors can result in turnover intentions for certain employees of organisations. Research purpose: The main objective of the study was to investigate how technology-based job autonomy, technology-based job overload and technologybased job monitoring impact turnover intentions of employees. Motivation of the study: Exploring and understanding the relationship between technology factors and turnover intention amongst government employees to determine whether these factors affect government as much as they affect the private sector. Research design, approach and method: This research used a quantitative research approach. It drew a convenience sample of 182 employees (N= 182) from the South African Government. Main findings: The three main findings of the study were: Technology-based job autonomy was positively related to turnover intention. Technology-based job overload was found to be positively related to turnover intention. Finally, technology-based monitoring was found to be positively related to turnover intention. Practical/managerial implications: If organisations do not address the issue of monitoring and overload they are likely to experience many turnover intentions amongst the employees. Furthermore, the organisations with less autonomy are likely to lose their employees which means they will lose the resources that have been serving the organisation for a long time. This will also contribute to the organisation losing many funds as they would constantly have to train new employees. Contribution/value-add: The research adds value to the knowledge about the effects of technology factors on turnover intention by pointing out the reasons that lead to turnover intention.
- Full Text:
- Date Issued: 2018
Preparation, characterization and in vitro analysis of polyamidoamine drug conjugates containing ferrocene and platinum analogues
- Authors: Mugogodi, Ansley
- Date: 2018
- Subjects: Ferrocene
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/10145 , vital:35360
- Description: Polyamidoamine drug conjugates were prepared from analogues of ferrocene and platinum. Standard reaction procedures were followed in the synthesis of platinum and ferrocene analogues. Michael addition reaction of amines to the activated double bonds of methylenebisacrylamide was applied for preparation of the water soluble polyamidoamine carriers onto which drug analogues were attached. The drug release studies of the conjugates were evaluated at different pH environments. The results obtained from drug release studies showed that rate of drug release was variable depending on the conjugate and pH environment. Mathematical drug release models by Korsmeyer-Peppas were used to determine the drug release characteristics of the ferrocene and platinum based drugs from polyamidoamine drug conjugates. Cytotoxicity potential of the analogues and polyamidoamine drug conjugates was tested on selected cell lines. Cisplatin was used as the standard for comparison of the IC50 values obtained for the compounds tested for cytotoxicity activity. The results from six polymer drug conjugates tested for cytotoxicity activity showed that conjugation of analogues to polyamidoamine carrier enhanced the activity of the analogues in some of the polyamidoamine drug conjugates. Various techniques such as Fourier Transform Infrared (FTIR) spectroscopy, Proton Nuclear Magnetic Resonance spectroscopy (1H NMR), Scanning Electron Microscopy (SEM), transmission electron microscopy (TEM), Transmission Electron Microscopy (TEM) and Energy Dispersive X-ray (EDX) spectroscopy were employed for the characterization of the ferrocene and platinum analogues, polyamidoamine carriers and drug conjugates.
- Full Text:
- Date Issued: 2018
- Authors: Mugogodi, Ansley
- Date: 2018
- Subjects: Ferrocene
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/10145 , vital:35360
- Description: Polyamidoamine drug conjugates were prepared from analogues of ferrocene and platinum. Standard reaction procedures were followed in the synthesis of platinum and ferrocene analogues. Michael addition reaction of amines to the activated double bonds of methylenebisacrylamide was applied for preparation of the water soluble polyamidoamine carriers onto which drug analogues were attached. The drug release studies of the conjugates were evaluated at different pH environments. The results obtained from drug release studies showed that rate of drug release was variable depending on the conjugate and pH environment. Mathematical drug release models by Korsmeyer-Peppas were used to determine the drug release characteristics of the ferrocene and platinum based drugs from polyamidoamine drug conjugates. Cytotoxicity potential of the analogues and polyamidoamine drug conjugates was tested on selected cell lines. Cisplatin was used as the standard for comparison of the IC50 values obtained for the compounds tested for cytotoxicity activity. The results from six polymer drug conjugates tested for cytotoxicity activity showed that conjugation of analogues to polyamidoamine carrier enhanced the activity of the analogues in some of the polyamidoamine drug conjugates. Various techniques such as Fourier Transform Infrared (FTIR) spectroscopy, Proton Nuclear Magnetic Resonance spectroscopy (1H NMR), Scanning Electron Microscopy (SEM), transmission electron microscopy (TEM), Transmission Electron Microscopy (TEM) and Energy Dispersive X-ray (EDX) spectroscopy were employed for the characterization of the ferrocene and platinum analogues, polyamidoamine carriers and drug conjugates.
- Full Text:
- Date Issued: 2018
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