Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow
- Musyoka, Thommas M, Kanzi, Aquillah M, Lobb, Kevin A, Tastan Bishop, Özlem
- Authors: Musyoka, Thommas M , Kanzi, Aquillah M , Lobb, Kevin A , Tastan Bishop, Özlem
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123074 , vital:35403 , https://doi.10.1080/07391102.2015.1108231
- Description: Malaria is an infectious disease caused by a diverse group of erythrocytic protozoan parasites of the genus Plasmodium. It remains an exigent public health problem in the tropical areas of Africa, South America and parts of Asia and continues to take its toll in morbidity and mortality with half of the world’s population under a permanent risk of infection leading to more than half a million deaths annually (WHO, 2013). Five Plasmodium species, namely P. falciparum (Pf ), P. vivax (Pv), P. ovale (Po), P. malariae (Pm) and P. knowlesi (Pk), are known to infect humans with Pf responsible for more than 90% of the malarial fatalities reported in sub-Saharan Africa. The predominance of Pf is attributed to its adaptability (Ashley, McGready, Proux, & Nosten, 2006; Prugnolle et al., 2011). Although the high occurrence of the Duffy negative trait among African populations lowers the threat posed by Pv, it is the most frequent and widely causative agent of benign tertian malaria in other parts of the world (Mendis, Sina, Marchesini, & Carter, 2001). In addition to the listed human malarial parasite forms, several other Plasmodium species, which infect non-human laboratory models, have been identified and are of significant importance in understanding the parasite biology, the host–parasite interactions and in the drug development process (Langhorne et al., 2011).
- Full Text:
- Date Issued: 2016
- Authors: Musyoka, Thommas M , Kanzi, Aquillah M , Lobb, Kevin A , Tastan Bishop, Özlem
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123074 , vital:35403 , https://doi.10.1080/07391102.2015.1108231
- Description: Malaria is an infectious disease caused by a diverse group of erythrocytic protozoan parasites of the genus Plasmodium. It remains an exigent public health problem in the tropical areas of Africa, South America and parts of Asia and continues to take its toll in morbidity and mortality with half of the world’s population under a permanent risk of infection leading to more than half a million deaths annually (WHO, 2013). Five Plasmodium species, namely P. falciparum (Pf ), P. vivax (Pv), P. ovale (Po), P. malariae (Pm) and P. knowlesi (Pk), are known to infect humans with Pf responsible for more than 90% of the malarial fatalities reported in sub-Saharan Africa. The predominance of Pf is attributed to its adaptability (Ashley, McGready, Proux, & Nosten, 2006; Prugnolle et al., 2011). Although the high occurrence of the Duffy negative trait among African populations lowers the threat posed by Pv, it is the most frequent and widely causative agent of benign tertian malaria in other parts of the world (Mendis, Sina, Marchesini, & Carter, 2001). In addition to the listed human malarial parasite forms, several other Plasmodium species, which infect non-human laboratory models, have been identified and are of significant importance in understanding the parasite biology, the host–parasite interactions and in the drug development process (Langhorne et al., 2011).
- Full Text:
- Date Issued: 2016
An integrated framework for assessing coastal community vulnerability across cultures, oceans and scales
- Aswani, Shankar, Howard, J A E, Gasalla, Maria A, Jennings, Sarah M, Malherbe, W, Martins, I M, Salim, Shyam S
- Authors: Aswani, Shankar , Howard, J A E , Gasalla, Maria A , Jennings, Sarah M , Malherbe, W , Martins, I M , Salim, Shyam S
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123063 , vital:35402 , https://doi.10.1080/17565529.2018.1442795
- Description: Across the globe, many coastal communities rely on marine resources for their food security (FS), income and livelihoods and with predicted trends in human populations, the number of people reliant on these resources is likely to increase (FAO, 2012). However, the effects of climate change including increased variability are already being experienced by coastal communities and appear to be accelerating (Doney et al., 2012). Depending on a range of factors, including location, these changes are having mild to severe impacts on communities both in direct and indirect ways (Miller et al., 2010). Communities in coastal areas, for instance, are particularly at risk due to sea level rise but also through their dependence on marine resources that are impacted by multiple climate change pressures. A change in the availability and condition of marine resources has consequences on the livelihoods of fishing populations or those who depend directly on fishing as a source of food (Badjeck, Allison, Halls, & Dulvy, 2010).
- Full Text:
- Date Issued: 2018
- Authors: Aswani, Shankar , Howard, J A E , Gasalla, Maria A , Jennings, Sarah M , Malherbe, W , Martins, I M , Salim, Shyam S
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123063 , vital:35402 , https://doi.10.1080/17565529.2018.1442795
- Description: Across the globe, many coastal communities rely on marine resources for their food security (FS), income and livelihoods and with predicted trends in human populations, the number of people reliant on these resources is likely to increase (FAO, 2012). However, the effects of climate change including increased variability are already being experienced by coastal communities and appear to be accelerating (Doney et al., 2012). Depending on a range of factors, including location, these changes are having mild to severe impacts on communities both in direct and indirect ways (Miller et al., 2010). Communities in coastal areas, for instance, are particularly at risk due to sea level rise but also through their dependence on marine resources that are impacted by multiple climate change pressures. A change in the availability and condition of marine resources has consequences on the livelihoods of fishing populations or those who depend directly on fishing as a source of food (Badjeck, Allison, Halls, & Dulvy, 2010).
- Full Text:
- Date Issued: 2018
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