Alzheimer’s disease: making sense of the stress
- Authors: Whiteley, Chris G
- Date: 2016
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67072 , vital:29029 , http://www.smgebooks.com/alzheimers-disease/chapters/ALZD-16-08.pdf
- Description: publisher version , To facilitate a deep understanding of the mechanisms involved in neurodegeneration and Alzheimer’s disease fundamental knowledge is required about the action and function of enzymes in the brain that not only metabolise arginine (neuronal nitric oxide synthase) but are closely associated with oxidative (superoxide dismutase; catalase; glutathione peroxidase) and/or nitrosative stress. In particular the focus extends towards enzymes that contribute to amyloid peptide aggregation and senile plaquedeposits (fibrillogenesis). Of special importance are the glycine zipper regions within these amyloid peptides, especially Aβ25-29 and Aβ29-33 (that contains two isoleucine residues) and the pentapeptide Aβ17-21 (that contains two phenylalanines), each generated by enzymatic cleavage of the intramembrane amyloid precursor protein. Use of antisense-sense technology has identified regions in each enzyme that are capable of binding with the amyloid peptides. After an initial inhibition of each enzyme there is an oligomerisation into soluble fibrils which accumulate and eventually precipitate. The use of nanoparticles do not just prevent but reverse the formation of these fibrils either by disrupting the binary adduct – enzyme-Aβ-peptide- or by reaction with, and therefore deplete, Aβ-monomers in solution and so block potential aggregation sites on the enzyme itself. Future therapy towards Alzheimer’s disease should target the C-terminal region of the amyloid precursor protein and substitute hydrophobic residues for the glycine amino acids within the glycine zipper region.
- Full Text:
- Authors: Whiteley, Chris G
- Date: 2016
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/67072 , vital:29029 , http://www.smgebooks.com/alzheimers-disease/chapters/ALZD-16-08.pdf
- Description: publisher version , To facilitate a deep understanding of the mechanisms involved in neurodegeneration and Alzheimer’s disease fundamental knowledge is required about the action and function of enzymes in the brain that not only metabolise arginine (neuronal nitric oxide synthase) but are closely associated with oxidative (superoxide dismutase; catalase; glutathione peroxidase) and/or nitrosative stress. In particular the focus extends towards enzymes that contribute to amyloid peptide aggregation and senile plaquedeposits (fibrillogenesis). Of special importance are the glycine zipper regions within these amyloid peptides, especially Aβ25-29 and Aβ29-33 (that contains two isoleucine residues) and the pentapeptide Aβ17-21 (that contains two phenylalanines), each generated by enzymatic cleavage of the intramembrane amyloid precursor protein. Use of antisense-sense technology has identified regions in each enzyme that are capable of binding with the amyloid peptides. After an initial inhibition of each enzyme there is an oligomerisation into soluble fibrils which accumulate and eventually precipitate. The use of nanoparticles do not just prevent but reverse the formation of these fibrils either by disrupting the binary adduct – enzyme-Aβ-peptide- or by reaction with, and therefore deplete, Aβ-monomers in solution and so block potential aggregation sites on the enzyme itself. Future therapy towards Alzheimer’s disease should target the C-terminal region of the amyloid precursor protein and substitute hydrophobic residues for the glycine amino acids within the glycine zipper region.
- Full Text:
Applications of social media and web 2.0 for research support in selected African academic institutions
- Owusu-Ansah, Christopher M, Gontshi, Vuyokazi, Mutibwa, Lois, Ukwoma, Scholarstica
- Authors: Owusu-Ansah, Christopher M , Gontshi, Vuyokazi , Mutibwa, Lois , Ukwoma, Scholarstica
- Date: 2015
- Subjects: Social networks , Web 2.0. , Research -- Study and teaching
- Language: English
- Type: Article
- Identifier: vital:6996 , http://hdl.handle.net/10962/d1018520
- Description: This study examined the use of Social Media/Web 2.0 for research support and it is guided by three objectives namely: a) to ascertain the uses of social media in academic institutions; b) to identify the challenges associated with social media use for research purposes and c) to provide experiences of social media application in selected African academic institutions. The study makes use of literature analysis in combination with personal and professional work experiences on the use of social media from librarians in four different countries. Institutional experiences of the four librarians showed that it is only Rhodes University Library that uses social media in its library, which is as a result of a formal social media strategy. For the other three universities, University of Education, Winneba Library in Ghana, Makerere University Library in Uganda and the University of Nigeria Library, the use of social media is not encouraging. They use it mostly for communication and interaction with colleagues. It was also discovered that there is no social media strategy available in these university libraries. Based on these findings, the study recommended the implementation of a social media strategy, appointment of social media librarians in these libraries, and continuing professional development of librarians to keep abreast with current trends. Web 2.0/Social Media is a new technology offering new options for African academic librarians in their research support role
- Full Text:
- Authors: Owusu-Ansah, Christopher M , Gontshi, Vuyokazi , Mutibwa, Lois , Ukwoma, Scholarstica
- Date: 2015
- Subjects: Social networks , Web 2.0. , Research -- Study and teaching
- Language: English
- Type: Article
- Identifier: vital:6996 , http://hdl.handle.net/10962/d1018520
- Description: This study examined the use of Social Media/Web 2.0 for research support and it is guided by three objectives namely: a) to ascertain the uses of social media in academic institutions; b) to identify the challenges associated with social media use for research purposes and c) to provide experiences of social media application in selected African academic institutions. The study makes use of literature analysis in combination with personal and professional work experiences on the use of social media from librarians in four different countries. Institutional experiences of the four librarians showed that it is only Rhodes University Library that uses social media in its library, which is as a result of a formal social media strategy. For the other three universities, University of Education, Winneba Library in Ghana, Makerere University Library in Uganda and the University of Nigeria Library, the use of social media is not encouraging. They use it mostly for communication and interaction with colleagues. It was also discovered that there is no social media strategy available in these university libraries. Based on these findings, the study recommended the implementation of a social media strategy, appointment of social media librarians in these libraries, and continuing professional development of librarians to keep abreast with current trends. Web 2.0/Social Media is a new technology offering new options for African academic librarians in their research support role
- Full Text:
Changing sediment yield and sediment dynamics in the Karoo uplands, South Africa : post-European impacts
- Foster, I D L, Rowntree, Kate M, Boardman, J, Mighall, T M
- Authors: Foster, I D L , Rowntree, Kate M , Boardman, J , Mighall, T M
- Date: 2012
- Language: English
- Type: Article
- Identifier: vital:6684 , http://hdl.handle.net/10962/d1006683
- Description: We provide an overview of published results and a significant body of new data from an ongoing research programme designed to reconstruct sediment yields and sources in small (<60 km2) catchments in the Eastern Cape, South Africa over the last 150 years. Our analysis of four catchments has determined that sediment yield increased significantly in the latter half of the 20th Century but that the exact timing of these increases was different in each of the four catchments. In two high altitude locations, sediment yield increases were not associated with a significant change in sediment source, although in one case areas of former cultivation appear to have made a slightly greater contribution since the 1960s. In a third catchment, increases in sediment yield appear to have been driven by the development of badlands and by an increase in connectivity between the badlands and the main channel network in the 1960s. In the fourth catchment, increased connectivity between the main catchment and dam occurred as a result of the construction of a causeway to carry a main road and by the construction of culverts beneath the road. Occasional changes in sediment source have also been identified in the sedimentary record but these were not linked directly to road construction. Research to date shows the complexity of sediment delivery in these semi-arid catchment systems and emphasises the need to combine sediment yield with source ascription in order to better understand the dynamics of these systems.
- Full Text:
- Authors: Foster, I D L , Rowntree, Kate M , Boardman, J , Mighall, T M
- Date: 2012
- Language: English
- Type: Article
- Identifier: vital:6684 , http://hdl.handle.net/10962/d1006683
- Description: We provide an overview of published results and a significant body of new data from an ongoing research programme designed to reconstruct sediment yields and sources in small (<60 km2) catchments in the Eastern Cape, South Africa over the last 150 years. Our analysis of four catchments has determined that sediment yield increased significantly in the latter half of the 20th Century but that the exact timing of these increases was different in each of the four catchments. In two high altitude locations, sediment yield increases were not associated with a significant change in sediment source, although in one case areas of former cultivation appear to have made a slightly greater contribution since the 1960s. In a third catchment, increases in sediment yield appear to have been driven by the development of badlands and by an increase in connectivity between the badlands and the main channel network in the 1960s. In the fourth catchment, increased connectivity between the main catchment and dam occurred as a result of the construction of a causeway to carry a main road and by the construction of culverts beneath the road. Occasional changes in sediment source have also been identified in the sedimentary record but these were not linked directly to road construction. Research to date shows the complexity of sediment delivery in these semi-arid catchment systems and emphasises the need to combine sediment yield with source ascription in order to better understand the dynamics of these systems.
- Full Text:
Checklist, endemism, English vernacular names and identification of the cicadas (Insecta, Hemiptera, Cicadidae) of KwaZulu-Natal, South Africa:
- Armstrong, Adrian J, Villet, Martin H
- Authors: Armstrong, Adrian J , Villet, Martin H
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140586 , vital:37901 , DOI: 10.3897/afrinvertebr.60.35130
- Description: Public understanding of the goals of applied biology and conservation is promoted by showcasing charismatic or significant organisms using vernacular names. Conservation activities in the province of KwaZulu-Natal, South Africa, are prioritising taxa that have high rates of provincial endemism, such as snails, earthworms, millipedes and cicadas. To assist wider public engagement in these activities, an assessment of endemism of the cicadas of KwaZulu-Natal is presented along with a dichotomous, 37-couplet key for the identification of males, based mainly on externally visible morphology and colouration. Standardised English vernacular names coined following a simple naming convention are proposed. Forty-two percent (16 out of 38) of the cicada species known from KwaZulu-Natal are endemic to the province. Photographs of some of the species are included to facilitate their identification. Photographs can be used for identification of various species providing that the diagnostic characters are visible in the photographs. For this purpose, photographs may have to be taken of hand-held individuals. Some of the endemic species are of particular concern for conservation because they are not known to occur in statutory protected areas or are only known from relatively small protected areas. The latter may not be able to ensure the long-term survival of the species. The rate and extent of loss of habitat outside protected areas is likely to be a grave threat to species that are not protected or that are inadequately conserved in statutory protected areas. The standardised vernacular names proposed here provide a tool for communicating provincial conservation plans and concerns with stakeholders in KwaZulu-Natal and for stimulating interest in cicadas amongst land users, environmental impact assessment practitioners, biologists, naturalists and citizen scientists.
- Full Text:
- Authors: Armstrong, Adrian J , Villet, Martin H
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140586 , vital:37901 , DOI: 10.3897/afrinvertebr.60.35130
- Description: Public understanding of the goals of applied biology and conservation is promoted by showcasing charismatic or significant organisms using vernacular names. Conservation activities in the province of KwaZulu-Natal, South Africa, are prioritising taxa that have high rates of provincial endemism, such as snails, earthworms, millipedes and cicadas. To assist wider public engagement in these activities, an assessment of endemism of the cicadas of KwaZulu-Natal is presented along with a dichotomous, 37-couplet key for the identification of males, based mainly on externally visible morphology and colouration. Standardised English vernacular names coined following a simple naming convention are proposed. Forty-two percent (16 out of 38) of the cicada species known from KwaZulu-Natal are endemic to the province. Photographs of some of the species are included to facilitate their identification. Photographs can be used for identification of various species providing that the diagnostic characters are visible in the photographs. For this purpose, photographs may have to be taken of hand-held individuals. Some of the endemic species are of particular concern for conservation because they are not known to occur in statutory protected areas or are only known from relatively small protected areas. The latter may not be able to ensure the long-term survival of the species. The rate and extent of loss of habitat outside protected areas is likely to be a grave threat to species that are not protected or that are inadequately conserved in statutory protected areas. The standardised vernacular names proposed here provide a tool for communicating provincial conservation plans and concerns with stakeholders in KwaZulu-Natal and for stimulating interest in cicadas amongst land users, environmental impact assessment practitioners, biologists, naturalists and citizen scientists.
- Full Text:
Cognitive therapy for social phobia : the human face of cognitive science
- Edwards, David J A, Henwood, Jennifer, Kannan, Swetha
- Authors: Edwards, David J A , Henwood, Jennifer , Kannan, Swetha
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6280 , http://hdl.handle.net/10962/d1008281
- Description: [abstract from Index to SA Periodicals]Points to the male/masculine ideology pervading science. Gives a history of cognitive science. Shows that current clinical models on which cognitive therapy treatments are based are complex and detailed, but also situated and human. Warns about the contemporary enthusiasm for cognitive science. Presents a case study which illustrates how the cognitive model of social phobia works inpractice when applied to one person's life situation.
- Full Text:
- Authors: Edwards, David J A , Henwood, Jennifer , Kannan, Swetha
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6280 , http://hdl.handle.net/10962/d1008281
- Description: [abstract from Index to SA Periodicals]Points to the male/masculine ideology pervading science. Gives a history of cognitive science. Shows that current clinical models on which cognitive therapy treatments are based are complex and detailed, but also situated and human. Warns about the contemporary enthusiasm for cognitive science. Presents a case study which illustrates how the cognitive model of social phobia works inpractice when applied to one person's life situation.
- Full Text:
Collaborative versus adversarial stances in scientific discourse : implications for the role of systematic case studies in the development of evidence-based practice in psychotherapy
- Authors: Edwards, David J A
- Date: 2007
- Language: English
- Type: Article
- Identifier: vital:6245 , http://hdl.handle.net/10962/d1007861
- Description: There is still a need for advocacy in the promotion of case study research because there has been insufficient appreciation of its role as a source of evidence relevant to the development and evaluation of practice in psychotherapy. Distorted use of terms like "gold standard", "anecdotal",and "empirical" in the discourse in which research methodology is typically presented has disempowered the practitioner's perspective and discredited the role of case-based knowledge building. The framework of evidence-based practice (EBP) recognizes the complementarity of different research methods and acknowledges the significance of casebased research. To spell out some of these complementary links, a typology of seven research methods - including both experimental group comparison designs and individual case studies - is proposed and the contribution of each to the development of EBP is set out. Finally some suggestions are made for strategies to promote the publication of high quality case studies.
- Full Text:
- Authors: Edwards, David J A
- Date: 2007
- Language: English
- Type: Article
- Identifier: vital:6245 , http://hdl.handle.net/10962/d1007861
- Description: There is still a need for advocacy in the promotion of case study research because there has been insufficient appreciation of its role as a source of evidence relevant to the development and evaluation of practice in psychotherapy. Distorted use of terms like "gold standard", "anecdotal",and "empirical" in the discourse in which research methodology is typically presented has disempowered the practitioner's perspective and discredited the role of case-based knowledge building. The framework of evidence-based practice (EBP) recognizes the complementarity of different research methods and acknowledges the significance of casebased research. To spell out some of these complementary links, a typology of seven research methods - including both experimental group comparison designs and individual case studies - is proposed and the contribution of each to the development of EBP is set out. Finally some suggestions are made for strategies to promote the publication of high quality case studies.
- Full Text:
Commission of Inquiry into Oukasie Violence
- UDF
- Authors: UDF
- Date: 1990
- Subjects: UDF
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/250651 , vital:52035
- Description: In June 1990, the United Democratic Front [UDF] appointed Brian Cumin, National Director of Lawyers for Human Rights as Commissioner to investigate and report on the reasons for the violence in Oukasie Township, Brits, since February 1986. Brian Cumin was empowered to appoint additional Commissioners to assist him. David Bam and Mpho Molefe, both practising Attorneys in Pretoria were duly appointed as co-commissioners. As part of their report on the reasons for the violence in Oukasie, the Commissioners have taken the liberty of making recommendations to the United Democratic Front.
- Full Text:
- Authors: UDF
- Date: 1990
- Subjects: UDF
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/250651 , vital:52035
- Description: In June 1990, the United Democratic Front [UDF] appointed Brian Cumin, National Director of Lawyers for Human Rights as Commissioner to investigate and report on the reasons for the violence in Oukasie Township, Brits, since February 1986. Brian Cumin was empowered to appoint additional Commissioners to assist him. David Bam and Mpho Molefe, both practising Attorneys in Pretoria were duly appointed as co-commissioners. As part of their report on the reasons for the violence in Oukasie, the Commissioners have taken the liberty of making recommendations to the United Democratic Front.
- Full Text:
Differentiations and intersections: a corpus-assisted discourse study of gender representations in the British press before, during and after the London Olympics 2012
- Jaworska, Sylvia, Hunt, Sally
- Authors: Jaworska, Sylvia , Hunt, Sally
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/139205 , vital:37714 , DOI 10.1558/genl.28858
- Description: This study examines the impact of a global sports event on gender representations in media reporting. Whereas previous research on gender, sport and media has been mainly concerned with sports events in the North American or Australian context, this study investigates the British media reporting before, during and after the London Olympics 2012. Our study follows the approach of Corpus-Assisted Discourse Studies (CADS) and uses both quantitative and qualitative research procedures. The results reveal more balanced gender representations during the London Olympics in that the ‘regular’ biased associations were supressed in favour of positive references to female achievements. However, little carry-though of the ‘gains’ was noted. Also, this study shows that the positive associations intersected with national sentiments and were used to celebrate the nation-state. At the same time, some subtle resistance was observed to accepting as ‘truly’ British the non-white athletes and those not born in Britain.
- Full Text:
- Authors: Jaworska, Sylvia , Hunt, Sally
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/139205 , vital:37714 , DOI 10.1558/genl.28858
- Description: This study examines the impact of a global sports event on gender representations in media reporting. Whereas previous research on gender, sport and media has been mainly concerned with sports events in the North American or Australian context, this study investigates the British media reporting before, during and after the London Olympics 2012. Our study follows the approach of Corpus-Assisted Discourse Studies (CADS) and uses both quantitative and qualitative research procedures. The results reveal more balanced gender representations during the London Olympics in that the ‘regular’ biased associations were supressed in favour of positive references to female achievements. However, little carry-though of the ‘gains’ was noted. Also, this study shows that the positive associations intersected with national sentiments and were used to celebrate the nation-state. At the same time, some subtle resistance was observed to accepting as ‘truly’ British the non-white athletes and those not born in Britain.
- Full Text:
Graviton n-point functions for UV-complete theories in Anti-de Sitter space
- Authors: Brustein, R , Medved, A J M
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6820 , http://hdl.handle.net/10962/d1004427
- Description: We calculate graviton n-point functions in an anti-de Sitter black brane background for effective gravity theories whose linearized equations of motion have at most two time derivatives. We compare the n-point functions in Einstein gravity to those in theories whose leading correction is quadratic in the Riemann tensor. The comparison is made for any number of gravitons and for all physical graviton modes in a kinematic region for which the leading correction can significantly modify the Einstein result. We find that the n-point functions of Einstein gravity depend on at most a single angle, whereas those of the corrected theories may depend on two angles. For the four-point functions, Einstein gravity exhibits linear dependence on the Mandelstam variable s versus a quadratic dependence on s for the corrected theory.
- Full Text:
- Authors: Brustein, R , Medved, A J M
- Date: 2012
- Language: English
- Type: text , Article
- Identifier: vital:6820 , http://hdl.handle.net/10962/d1004427
- Description: We calculate graviton n-point functions in an anti-de Sitter black brane background for effective gravity theories whose linearized equations of motion have at most two time derivatives. We compare the n-point functions in Einstein gravity to those in theories whose leading correction is quadratic in the Riemann tensor. The comparison is made for any number of gravitons and for all physical graviton modes in a kinematic region for which the leading correction can significantly modify the Einstein result. We find that the n-point functions of Einstein gravity depend on at most a single angle, whereas those of the corrected theories may depend on two angles. For the four-point functions, Einstein gravity exhibits linear dependence on the Mandelstam variable s versus a quadratic dependence on s for the corrected theory.
- Full Text:
Impact of emerging mutations on the dynamic properties the SARS-CoV-2 main protease: an in silico investigation
- Amamuddy, Olivier S, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163035 , vital:41006 , doi: 10.1021/acs.jcim.0c00634
- Description: The new coronavirus (SARS-CoV-2) is a global threat to world health and its economy. Its main protease (Mpro), which functions as a dimer, cleaves viral precursor proteins in the process of viral maturation. It is a good candidate for drug development owing to its conservation and the absence of a human homolog. An improved understanding of the protein behaviour can accelerate the discovery of effective therapies in order to reduce mortality. 100 ns all-atom molecular dynamics simulations of 50 homology modelled mutant Mpro dimers were performed at pH 7 from filtered sequences obtained from the GISAID database. Protease dynamics were analysed using RMSD, RMSF, Rg, the averaged betweenness centrality and geometry calculations. Domains from each Mpro protomer were found to generally have independent motions, while the dimer-stabilising N-finger region was found to be flexible in most mutants.
- Full Text:
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163035 , vital:41006 , doi: 10.1021/acs.jcim.0c00634
- Description: The new coronavirus (SARS-CoV-2) is a global threat to world health and its economy. Its main protease (Mpro), which functions as a dimer, cleaves viral precursor proteins in the process of viral maturation. It is a good candidate for drug development owing to its conservation and the absence of a human homolog. An improved understanding of the protein behaviour can accelerate the discovery of effective therapies in order to reduce mortality. 100 ns all-atom molecular dynamics simulations of 50 homology modelled mutant Mpro dimers were performed at pH 7 from filtered sequences obtained from the GISAID database. Protease dynamics were analysed using RMSD, RMSF, Rg, the averaged betweenness centrality and geometry calculations. Domains from each Mpro protomer were found to generally have independent motions, while the dimer-stabilising N-finger region was found to be flexible in most mutants.
- Full Text:
Institutional Repositories and Regional Collaboration: the Content Pro IRX Implementation at SEALS
- Clarke, Roelien, Van der Walt, Wynand
- Authors: Clarke, Roelien , Van der Walt, Wynand
- Date: 2013
- Language: English
- Type: Conference paper , text
- Identifier: vital:6977 , http://hdl.handle.net/10962/d1007310
- Description: Paper delivered at the Annual Innovative User Group South Africa (IUGSA) Conference held in Bloemfontein, University of the Free State, 13-15 November 2013
- Full Text:
- Authors: Clarke, Roelien , Van der Walt, Wynand
- Date: 2013
- Language: English
- Type: Conference paper , text
- Identifier: vital:6977 , http://hdl.handle.net/10962/d1007310
- Description: Paper delivered at the Annual Innovative User Group South Africa (IUGSA) Conference held in Bloemfontein, University of the Free State, 13-15 November 2013
- Full Text:
Legislative provisions, origins, and transformative possibilities
- NALEDI
- Authors: NALEDI
- Date: 1998
- Subjects: NALEDI
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/151359 , vital:39058
- Description: This research report was commissioned by NALEDI as part of its long term research project on Co-determination and Tripartism in South Africa. The transition to democracy in South Africa has been accompanied by a range of institutions and processes through which ordinary workers and their organisations may gain varying degrees of control over economic decisions that directly affect their lives. Scholars and practitioners have focussed attention on parts of these changes - such as NEDLAC or the workplace forum provisions of the Labour Relations Act - while missing its more systematic features: its wide scope from the factory floor to the societal level, and the extent to which labour has obtained strong decisionmaking and consultation rights founded in both statute and agreement. Taken together these features have the potential to deepen dramatically the political democracy won in 1994. Yet these developments are generally untheorised and remain seriously underresearched. In mid-1996 NALEDI embarked on this long term research project to investigate the dramatic changes that are occurring regarding worker representation at the workplace, industry, and societal levels. The full list of reports produced by this project is set out below. While the contributions are academically informed, they are aimed at examining key issues in a critical fashion to inform trade unionists and contribute to labour movement policy debates.
- Full Text:
- Authors: NALEDI
- Date: 1998
- Subjects: NALEDI
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/151359 , vital:39058
- Description: This research report was commissioned by NALEDI as part of its long term research project on Co-determination and Tripartism in South Africa. The transition to democracy in South Africa has been accompanied by a range of institutions and processes through which ordinary workers and their organisations may gain varying degrees of control over economic decisions that directly affect their lives. Scholars and practitioners have focussed attention on parts of these changes - such as NEDLAC or the workplace forum provisions of the Labour Relations Act - while missing its more systematic features: its wide scope from the factory floor to the societal level, and the extent to which labour has obtained strong decisionmaking and consultation rights founded in both statute and agreement. Taken together these features have the potential to deepen dramatically the political democracy won in 1994. Yet these developments are generally untheorised and remain seriously underresearched. In mid-1996 NALEDI embarked on this long term research project to investigate the dramatic changes that are occurring regarding worker representation at the workplace, industry, and societal levels. The full list of reports produced by this project is set out below. While the contributions are academically informed, they are aimed at examining key issues in a critical fashion to inform trade unionists and contribute to labour movement policy debates.
- Full Text:
Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock, and its proposed nuclear localization signal is involved in Hsp90 binding
- Daniel, Sheril, Bradley, Graeme, Longshaw, Victoria M, Söti, Csaba, Csermely, Peter, Blatch, Gregory L
- Authors: Daniel, Sheril , Bradley, Graeme , Longshaw, Victoria M , Söti, Csaba , Csermely, Peter , Blatch, Gregory L
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6472 , http://hdl.handle.net/10962/d1005951 , http://dx.doi.org/10.1016/j.bbamcr.2008.01.014
- Description: The Hsp70–Hsp90 complex is implicated in the folding and regulation of numerous signaling proteins, and Hop, the Hsp70–Hsp90 Organizing Protein, facilitates the association of this multichaperone machinery. Phosphatase treatment of mouse cell extracts reduced the number of Hop isoforms compared to untreated extracts, providing the first direct evidence that Hop was phosphorylated in vivo. Furthermore, surface plasmon resonance (SPR) spectroscopy showed that a cdc2 kinase phosphorylation mimic of Hop had reduced affinity for Hsp90 binding. Hop was predominantly cytoplasmic, but translocated to the nucleus in response to heat shock. A putative bipartite nuclear localization signal (NLS) has been identified within the Hsp90-binding domain of Hop. Although substitution of residues within the major arm of this proposed NLS abolished Hop–Hsp90 interaction as determined by SPR, this was not sufficient to prevent the nuclear accumulation of Hop under leptomycin-B treatment and heat shock conditions. These results showed for the first time that the subcellular localization of Hop was stress regulated and that the major arm of the putative NLS was not directly important for nuclear translocation but was critical for Hop–Hsp90 association in vitro. We propose a model in which the association of Hop with Hsp90 and the phosphorylated status of Hop both play a role in the mechanism of nucleo-cytoplasmic shuttling of Hop.
- Full Text:
- Authors: Daniel, Sheril , Bradley, Graeme , Longshaw, Victoria M , Söti, Csaba , Csermely, Peter , Blatch, Gregory L
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6472 , http://hdl.handle.net/10962/d1005951 , http://dx.doi.org/10.1016/j.bbamcr.2008.01.014
- Description: The Hsp70–Hsp90 complex is implicated in the folding and regulation of numerous signaling proteins, and Hop, the Hsp70–Hsp90 Organizing Protein, facilitates the association of this multichaperone machinery. Phosphatase treatment of mouse cell extracts reduced the number of Hop isoforms compared to untreated extracts, providing the first direct evidence that Hop was phosphorylated in vivo. Furthermore, surface plasmon resonance (SPR) spectroscopy showed that a cdc2 kinase phosphorylation mimic of Hop had reduced affinity for Hsp90 binding. Hop was predominantly cytoplasmic, but translocated to the nucleus in response to heat shock. A putative bipartite nuclear localization signal (NLS) has been identified within the Hsp90-binding domain of Hop. Although substitution of residues within the major arm of this proposed NLS abolished Hop–Hsp90 interaction as determined by SPR, this was not sufficient to prevent the nuclear accumulation of Hop under leptomycin-B treatment and heat shock conditions. These results showed for the first time that the subcellular localization of Hop was stress regulated and that the major arm of the putative NLS was not directly important for nuclear translocation but was critical for Hop–Hsp90 association in vitro. We propose a model in which the association of Hop with Hsp90 and the phosphorylated status of Hop both play a role in the mechanism of nucleo-cytoplasmic shuttling of Hop.
- Full Text:
Organisation Building Workshop Report
- SADTU
- Authors: SADTU
- Date: Nov 1995
- Subjects: SADTU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/137734 , vital:37554
- Description: Summary Report on SADTU Organisation Building Workshop held on Friday 17 November - Bellville College of Education: There were approximately 40 participants representing the leadership of most SADTU branches in the Region. As per the programme, the purpose of the workshop was " to develop an organising and recruitment strategy with the aim of building capacity and to resuscitate union structures..." As with most strategy and organisational building attempts it is often difficult to ascertain what the organisational problems are which are within members/workshop participants own capabilities of solving. From the outset it is important to ensure the distinction between real organisational problems and perceived ones. Failure to ensure this would cause that the participants and the regional leadership could be found wanting, "barking up the wrong tree". It is for this reason that the opening exercise of the workshop was extremely usefull in ensuring an organisational assessment and isolating key problems. Participants were divided into five groups, A - E. Their task was to identify which animal most aptly represented SADTU, nationally and especially regionally. The groups were required to debate and reach concensus on the choice of animal and motivate fully. Participants tackled the task with enthusiasm, were very creative and seemed to enjoy the exercise. Groups were then to report back to a plenary session in the form of a drawing of their animals and a list of points motivating their choice. The idea was that the plenary session would debate the choices and try to reach concensus on the most representative animal.
- Full Text:
- Authors: SADTU
- Date: Nov 1995
- Subjects: SADTU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/137734 , vital:37554
- Description: Summary Report on SADTU Organisation Building Workshop held on Friday 17 November - Bellville College of Education: There were approximately 40 participants representing the leadership of most SADTU branches in the Region. As per the programme, the purpose of the workshop was " to develop an organising and recruitment strategy with the aim of building capacity and to resuscitate union structures..." As with most strategy and organisational building attempts it is often difficult to ascertain what the organisational problems are which are within members/workshop participants own capabilities of solving. From the outset it is important to ensure the distinction between real organisational problems and perceived ones. Failure to ensure this would cause that the participants and the regional leadership could be found wanting, "barking up the wrong tree". It is for this reason that the opening exercise of the workshop was extremely usefull in ensuring an organisational assessment and isolating key problems. Participants were divided into five groups, A - E. Their task was to identify which animal most aptly represented SADTU, nationally and especially regionally. The groups were required to debate and reach concensus on the choice of animal and motivate fully. Participants tackled the task with enthusiasm, were very creative and seemed to enjoy the exercise. Groups were then to report back to a plenary session in the form of a drawing of their animals and a list of points motivating their choice. The idea was that the plenary session would debate the choices and try to reach concensus on the most representative animal.
- Full Text:
Photophysicochemical and fFluorescence quenching studies of benzyloxyphenoxy substituted zinc phthalocyanines
- Authors: Durmuş, M , Nyokong, Tebello
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6570 , http://hdl.handle.net/10962/d1004133
- Description: Photochemical and photophysical measurements were conducted on peripheral and non-peripheral tetrakis- and octakis(4-benzyloxyphenoxy)-substituted zinc phthalocyanines (1, 2 and 3). General trends are described for photodegradation, and fluorescence quantum yields, triplet lifetimes and triplet quantum yields as well as singlet oxygen quantum yields of these compounds in dimethylsulphoxide (DMSO) and toluene. The fluorescence of the complexes is quenched by benzoquinone (BQ), and fluorescence quenching properties are investigated in DMSO and toluene. The effects of the solvents on the photophysical and photochemical parameters of the zinc(II) phthalocyanines (1, 2 and 3) are also reported. Photophysical and photochemical properties of phthalocyanine complexes are very useful for PDT applications.
- Full Text:
- Authors: Durmuş, M , Nyokong, Tebello
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6570 , http://hdl.handle.net/10962/d1004133
- Description: Photochemical and photophysical measurements were conducted on peripheral and non-peripheral tetrakis- and octakis(4-benzyloxyphenoxy)-substituted zinc phthalocyanines (1, 2 and 3). General trends are described for photodegradation, and fluorescence quantum yields, triplet lifetimes and triplet quantum yields as well as singlet oxygen quantum yields of these compounds in dimethylsulphoxide (DMSO) and toluene. The fluorescence of the complexes is quenched by benzoquinone (BQ), and fluorescence quenching properties are investigated in DMSO and toluene. The effects of the solvents on the photophysical and photochemical parameters of the zinc(II) phthalocyanines (1, 2 and 3) are also reported. Photophysical and photochemical properties of phthalocyanine complexes are very useful for PDT applications.
- Full Text:
Redressing apartheid's legacy of social exclusion: social equity, redress and admission to higher education in South Africa
- Authors: Badat, Saleem
- Date: 2013
- Language: English
- Type: Text
- Identifier: vital:7931 , http://hdl.handle.net/10962/d1016481
- Full Text:
- Authors: Badat, Saleem
- Date: 2013
- Language: English
- Type: Text
- Identifier: vital:7931 , http://hdl.handle.net/10962/d1016481
- Full Text:
Rhodes University Graduation Ceremony 1999
- Authors: Rhodes University
- Date: 1999
- Language: English
- Type: text
- Identifier: vital:8133 , http://hdl.handle.net/10962/d1006778
- Description: Rhodes University 1999 Graduation Ceremonies [at] 1820 Settlers National Monument Friday, 9 April 1999 at 18:00 p.m. [and] 10 April 1999 at 10:30 a.m. , The Installation of Gert Johannes Gerwel as Chancellor of Rhodes University to be followed by a Graduation Ceremony 1820 Settlers National Monument Friday, 9 April 1999 at 10:30 a.m. , Rhodes University 1999 Graduation Ceremony City Hall, East London Friday, 7 May 1999 at 18:00 p.m.
- Full Text:
- Authors: Rhodes University
- Date: 1999
- Language: English
- Type: text
- Identifier: vital:8133 , http://hdl.handle.net/10962/d1006778
- Description: Rhodes University 1999 Graduation Ceremonies [at] 1820 Settlers National Monument Friday, 9 April 1999 at 18:00 p.m. [and] 10 April 1999 at 10:30 a.m. , The Installation of Gert Johannes Gerwel as Chancellor of Rhodes University to be followed by a Graduation Ceremony 1820 Settlers National Monument Friday, 9 April 1999 at 10:30 a.m. , Rhodes University 1999 Graduation Ceremony City Hall, East London Friday, 7 May 1999 at 18:00 p.m.
- Full Text:
Rhodes University Library Services Annual Report 2014 : "Our Scholarly Heartbeat"
- Authors: Satgoor, Ujala
- Date: 2015
- Language: English
- Type: Text
- Identifier: vital:7947 , http://hdl.handle.net/10962/d1020651
- Description: Library Director's Message: 2014 was indeed a momentous year for South Africans who embraced the opportunity to assess, evaluate and celebrate what has come to pass during these two decades of democracy. The library and information services (LIS) sector adopted the theme “Celebrating libraries in 20 years of democracy” which enabled several conversations to be held around three simple questions posed by Michael K Buckland: 1.What kind of work we do? 2.How can we do our work? 3.Why do we do our work? Buckland further asserts that modern society exists on a foundation of documents of all genres and forms, which are not just objectified knowledge but that they affect us aesthetically and emotionally. The use of documents is a cultural activity, be it through discussion or the exchange of documents. Vesa Souminen, in his book, Filling Empty Spaces, identifies that the crux of a good librarian’s role is to create arrangements of documents that are meaningful for users. In the face of technological advances, the relevance of libraries and librarians is raised and the need to create an awareness of what we do has never been as important as it is today. There are four accepted practices that define how we do our work: •Organization of information – selecting, collecting, organizing, categorizing, indexing, filtering and retrieval •Information in society and information policy – complementing and balancing the effects of the influence of the distribution and use of information in society •Technology for information which enables existing services to be performed differently as well as to develop different and better services •Management of information services – the art of achieving results through well-‐skilled competent people and how to survive and thrive in a political and economic environment. So why do we do what we do? Because it matters what people know! What people know is important to the individual, to an institution and to society. We do not only support technical knowledge but also cultural understanding, aesthetic insight and human behavior. Our role is to facilitate understanding of our shared identity that are collected and preserved in the records, documents, texts, etc that are our specialty. So when we say our purpose is to serve a community, we must be able to relate to the priorities and values of our role in that community. Given the above, the Rhodes University Library (RUL) embraced the 2nd year of its strategic plan (2013-‐2015) wholeheartedly with the express aim of consolidating practice, technology, providing universal access and ensuring an enabling environment and services for the broader Rhodes community. It therefore gives me great pleasure to present the 2014 annual report of the Rhodes University Library (RUL) which details how collectively the staff ensured that the defined practices were translated into reality.
- Full Text:
- Authors: Satgoor, Ujala
- Date: 2015
- Language: English
- Type: Text
- Identifier: vital:7947 , http://hdl.handle.net/10962/d1020651
- Description: Library Director's Message: 2014 was indeed a momentous year for South Africans who embraced the opportunity to assess, evaluate and celebrate what has come to pass during these two decades of democracy. The library and information services (LIS) sector adopted the theme “Celebrating libraries in 20 years of democracy” which enabled several conversations to be held around three simple questions posed by Michael K Buckland: 1.What kind of work we do? 2.How can we do our work? 3.Why do we do our work? Buckland further asserts that modern society exists on a foundation of documents of all genres and forms, which are not just objectified knowledge but that they affect us aesthetically and emotionally. The use of documents is a cultural activity, be it through discussion or the exchange of documents. Vesa Souminen, in his book, Filling Empty Spaces, identifies that the crux of a good librarian’s role is to create arrangements of documents that are meaningful for users. In the face of technological advances, the relevance of libraries and librarians is raised and the need to create an awareness of what we do has never been as important as it is today. There are four accepted practices that define how we do our work: •Organization of information – selecting, collecting, organizing, categorizing, indexing, filtering and retrieval •Information in society and information policy – complementing and balancing the effects of the influence of the distribution and use of information in society •Technology for information which enables existing services to be performed differently as well as to develop different and better services •Management of information services – the art of achieving results through well-‐skilled competent people and how to survive and thrive in a political and economic environment. So why do we do what we do? Because it matters what people know! What people know is important to the individual, to an institution and to society. We do not only support technical knowledge but also cultural understanding, aesthetic insight and human behavior. Our role is to facilitate understanding of our shared identity that are collected and preserved in the records, documents, texts, etc that are our specialty. So when we say our purpose is to serve a community, we must be able to relate to the priorities and values of our role in that community. Given the above, the Rhodes University Library (RUL) embraced the 2nd year of its strategic plan (2013-‐2015) wholeheartedly with the express aim of consolidating practice, technology, providing universal access and ensuring an enabling environment and services for the broader Rhodes community. It therefore gives me great pleasure to present the 2014 annual report of the Rhodes University Library (RUL) which details how collectively the staff ensured that the defined practices were translated into reality.
- Full Text:
Sorption of hydrophobic organic compounds on natural sorbents and organoclays from aqueous and non-aqueous solutions: a mini-review
- Moyo, Francis, Tandlich, Roman, Wilhelmi, Brendan S, Balaz, Stefan
- Authors: Moyo, Francis , Tandlich, Roman , Wilhelmi, Brendan S , Balaz, Stefan
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/71614 , vital:29925 , https://doi.org/10.3390/ijerph110505020
- Description: Renewed focus on the sorption of hydrophobic organic chemicals (HOCs) onto mineral surfaces and soil components is required due to the increased and wider range of organic pollutants being released into the environment. This mini-review examines the possibility of the contribution and mechanism of HOC sorption onto clay mineral sorbents such as kaolinite, and soil organic matter and the possible role of both in the prevention of environmental contamination by HOCs. Literature data indicates that certain siloxane surfaces can be hydrophobic. Therefore soils can retain HOCs even at low soil organic levels and the extent will depend on the structure of the pollutant and the type and concentration of clay minerals in the sorbent. Clay minerals are wettable by nonpolar solvents and so sorption of HOCs onto them from aqueous and non-aqueous solutions is possible. This is important for two reasons: firstly, the movement and remediation of soil environments will be a function of the concentration and type of clay minerals in the soil. Secondly, low-cost sorbents such as kaolinite and expandable clays can be added to soils or contaminated environments as temporary retention barriers for HOCs. Inorganic cations sorbed onto the kaolinite have a strong influence on the rate and extent of sorption of hydrophobic organic pollutants onto kaolinite. Structural sorbate classes that can be retained by the kaolinite matrix are limited by hydrogen bonding between hydroxyl groups of the octahedral alumosilicate sheet and the tetrahedral sheet with silicon. Soil organic carbon plays a key role in the sorption of HOCs onto soils, but the extent will be strongly affected by the structure of the organic soil matter and the presence of soot. Structural characterisation of soil organic matter in a particular soil should be conducted during a particular contamination event. Contamination by mining extractants and antibiotics will require renewed focus on the use of the QSAR approaches in the context of the sorption of HOCs onto clay minerals from aqueous and non-aqueous solutions.
- Full Text:
- Authors: Moyo, Francis , Tandlich, Roman , Wilhelmi, Brendan S , Balaz, Stefan
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/71614 , vital:29925 , https://doi.org/10.3390/ijerph110505020
- Description: Renewed focus on the sorption of hydrophobic organic chemicals (HOCs) onto mineral surfaces and soil components is required due to the increased and wider range of organic pollutants being released into the environment. This mini-review examines the possibility of the contribution and mechanism of HOC sorption onto clay mineral sorbents such as kaolinite, and soil organic matter and the possible role of both in the prevention of environmental contamination by HOCs. Literature data indicates that certain siloxane surfaces can be hydrophobic. Therefore soils can retain HOCs even at low soil organic levels and the extent will depend on the structure of the pollutant and the type and concentration of clay minerals in the sorbent. Clay minerals are wettable by nonpolar solvents and so sorption of HOCs onto them from aqueous and non-aqueous solutions is possible. This is important for two reasons: firstly, the movement and remediation of soil environments will be a function of the concentration and type of clay minerals in the soil. Secondly, low-cost sorbents such as kaolinite and expandable clays can be added to soils or contaminated environments as temporary retention barriers for HOCs. Inorganic cations sorbed onto the kaolinite have a strong influence on the rate and extent of sorption of hydrophobic organic pollutants onto kaolinite. Structural sorbate classes that can be retained by the kaolinite matrix are limited by hydrogen bonding between hydroxyl groups of the octahedral alumosilicate sheet and the tetrahedral sheet with silicon. Soil organic carbon plays a key role in the sorption of HOCs onto soils, but the extent will be strongly affected by the structure of the organic soil matter and the presence of soot. Structural characterisation of soil organic matter in a particular soil should be conducted during a particular contamination event. Contamination by mining extractants and antibiotics will require renewed focus on the use of the QSAR approaches in the context of the sorption of HOCs onto clay minerals from aqueous and non-aqueous solutions.
- Full Text:
South Asian diasporic women's short fiction: the South African contribution
- Authors: Naidu, Samantha
- Date: 2007
- Language: English
- Type: Article , text
- Identifier: vital:26376 , http://hdl.handle.net/10962/54037 , https://orcid.org/0000-0001-9456-8657
- Description: Although Indian Women S Short Fiction Has Always Enjoyed Equal Importance And Popularity As Their Novels, Very Little Critical Attention Has Been Paid To It So Far. Indian Women S Short Fiction Seeks To Fulfil This Long Felt Need. It Puts Together Fifteen Perceptive And Analytical Articles By Scholars Across The World. The Articles, Which Are Focussed On Native Indian Writing As Well As Diasporic Short Fiction, Deal With Such Interesting Literary Issues As Construction Of Femininity, Disablement And Enablement, Bengali Heritage, Hybrid Identities, Nostalgia, Representation Of The Partition Violence, Tradition And Modernity, And Cultural Perspectivism.
- Full Text: false
- Authors: Naidu, Samantha
- Date: 2007
- Language: English
- Type: Article , text
- Identifier: vital:26376 , http://hdl.handle.net/10962/54037 , https://orcid.org/0000-0001-9456-8657
- Description: Although Indian Women S Short Fiction Has Always Enjoyed Equal Importance And Popularity As Their Novels, Very Little Critical Attention Has Been Paid To It So Far. Indian Women S Short Fiction Seeks To Fulfil This Long Felt Need. It Puts Together Fifteen Perceptive And Analytical Articles By Scholars Across The World. The Articles, Which Are Focussed On Native Indian Writing As Well As Diasporic Short Fiction, Deal With Such Interesting Literary Issues As Construction Of Femininity, Disablement And Enablement, Bengali Heritage, Hybrid Identities, Nostalgia, Representation Of The Partition Violence, Tradition And Modernity, And Cultural Perspectivism.
- Full Text: false