Versions of hospitality in recent writing on the fiction of JM Coetzee:
- Authors: Marais, Mike
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144039 , vital:38305 , DOI: 10.4314/eia.v40i1.8
- Description: In one of the interviews in Summertime, Martin, a former colleague, claims that he and the deceased John Coetzee felt their "presence" in South Africa "was legal but illegitimate," that it "was grounded in a crime, namely colonial conquest," which rendered them "sojourners, temporary residents, and to that extent without a home, without a homeland" (209-10). With this statement in mind, Maria J. Lopez argues that a sense of unbelonging underlies J. M. Coetzee's entire oeuvre, including the Australian fiction, and forms a kind of "imaginative and intellectual masterplot" (xii). ). It is this "narrative" that she traces in her monograph, starting with the early fiction and concluding with chapters on the fictionalised autobiographies and Australian fiction.
- Full Text:
- Date Issued: 2013
- Authors: Marais, Mike
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144039 , vital:38305 , DOI: 10.4314/eia.v40i1.8
- Description: In one of the interviews in Summertime, Martin, a former colleague, claims that he and the deceased John Coetzee felt their "presence" in South Africa "was legal but illegitimate," that it "was grounded in a crime, namely colonial conquest," which rendered them "sojourners, temporary residents, and to that extent without a home, without a homeland" (209-10). With this statement in mind, Maria J. Lopez argues that a sense of unbelonging underlies J. M. Coetzee's entire oeuvre, including the Australian fiction, and forms a kind of "imaginative and intellectual masterplot" (xii). ). It is this "narrative" that she traces in her monograph, starting with the early fiction and concluding with chapters on the fictionalised autobiographies and Australian fiction.
- Full Text:
- Date Issued: 2013
The time of hospitality in Samuel Beckett's Murphy, Michael Ondaatje's The English Patient and Damon Galgut's The Good Doctor:
- Authors: Marais, Mike
- Date: 2015
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144106 , vital:38312 , DOI: 10.1080/00138398.2015.1083193
- Description: In this article, I focus on the temporal dimension of the differential process through which community constitutes itself. If community is premised on the sameness that is enabled by that which it excludes, and sees as a threat, then it must seek always to conserve itself and to render the future – which is hazardous in its uncertainty – calculable, predictable and determinable. In its search for stability and permanence, community must dominate time in such a way that it is overcome, that it withdraws from itself. Arguably, though, we would view time less teleologically and programmatically, if we could relate differently to the difference on which community depends. A form of hospitality that is predicated on an acceptance of otherness – not only that of a community's outsiders, but also the ‘common strangeness’ of its insiders – would alter the ways in which being-in-common is conceived, and would also change our experience of belonging.
- Full Text:
- Date Issued: 2015
- Authors: Marais, Mike
- Date: 2015
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144106 , vital:38312 , DOI: 10.1080/00138398.2015.1083193
- Description: In this article, I focus on the temporal dimension of the differential process through which community constitutes itself. If community is premised on the sameness that is enabled by that which it excludes, and sees as a threat, then it must seek always to conserve itself and to render the future – which is hazardous in its uncertainty – calculable, predictable and determinable. In its search for stability and permanence, community must dominate time in such a way that it is overcome, that it withdraws from itself. Arguably, though, we would view time less teleologically and programmatically, if we could relate differently to the difference on which community depends. A form of hospitality that is predicated on an acceptance of otherness – not only that of a community's outsiders, but also the ‘common strangeness’ of its insiders – would alter the ways in which being-in-common is conceived, and would also change our experience of belonging.
- Full Text:
- Date Issued: 2015
Developmental Psychology, Psychological Testing & Assessment, Research Methods: PSY 222
- Authors: Marais, R , Hoho, V N
- Date: 2012-01
- Language: English
- Type: Examination paper
- Identifier: vital:18014 , http://hdl.handle.net/10353/d1010591
- Description: Developmental Psychology, Psychological Testing & Assessment, Research Methods: PSY 222, Supplementary examination January 2012.
- Full Text: false
- Date Issued: 2012-01
- Authors: Marais, R , Hoho, V N
- Date: 2012-01
- Language: English
- Type: Examination paper
- Identifier: vital:18014 , http://hdl.handle.net/10353/d1010591
- Description: Developmental Psychology, Psychological Testing & Assessment, Research Methods: PSY 222, Supplementary examination January 2012.
- Full Text: false
- Date Issued: 2012-01
Abortion in legal, social, and healthcare contexts
- Marecek, Jeanne, Macleod, Catriona I, Hoggart, Lesley
- Authors: Marecek, Jeanne , Macleod, Catriona I , Hoggart, Lesley
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68478 , vital:29262 , https://doi.org/10.1177/0959353516689521
- Description: Publisher version , From Introduction: The subject of abortion is both timely and of high relevance to feminists. In the past few months, women’s access to abortion has been contested in various parts of the world. In many countries in Latin America, the Zika outbreak raised the demand for abortions among pregnant women who had contracted (or feared contracting) the virus, with its risk of severe foetal abnormalities. In Poland, mass demonstrations by women succeeded in turning back proposed legislation prohibiting abortions. The outcome of the U.S. elections in late 2016 raised grave concerns about the future of American women’s access to abortion, which was already limited by stringent regulations and funding restrictions. We chose the title ‘‘Abortion in Context’’ to signal that we sought to publish work that moved beyond examining abortion as a ‘‘stress experience’’ encountered by individual women or as a possible precursor of mental illness. Our goal was to assemble a set of articles that would prompt readers to think critically about practices and discourses surrounding abortion. We further hoped to include work that would address the meanings and practices of abortion in the global South and among minoritized groups in the global North. We were pleased by the enthusiastic response to our Call for Papers. We note that Eklund and Purewal (2017, this issue) address abortion in China and India. Thoradeniya’s (2017, this issue) review of Abortion in Asia (Whittaker, 2010) provides a glimpse of the complex and varied practices, policies, and experiences of abortion in parts of South and Southeast Asia. Chiweshe, Mavuso, and Macleod (whose work will appear in Part 2 of the Special Issue) take up abortion in South Africa and Zimbabwe. Le Grice and Braun (whose work will also appear in Part 2), examine Maori perspectives on abortion. In this Part 1 of the Special Issue, we present work that locates abortion practices and policies in legal, social, and healthcare contexts. Women’s efforts to exercise agency with regard to bodily integrity in the context of pregnancy are shaped most obviously by the legal regulations in the jurisdictions where they live, but they are also shaped by social and cultural issues, biotechnological advances, and healthcare systems. The articles offer detailed examinations of some of these complex contextual framings of abortion.
- Full Text:
- Date Issued: 2017
- Authors: Marecek, Jeanne , Macleod, Catriona I , Hoggart, Lesley
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68478 , vital:29262 , https://doi.org/10.1177/0959353516689521
- Description: Publisher version , From Introduction: The subject of abortion is both timely and of high relevance to feminists. In the past few months, women’s access to abortion has been contested in various parts of the world. In many countries in Latin America, the Zika outbreak raised the demand for abortions among pregnant women who had contracted (or feared contracting) the virus, with its risk of severe foetal abnormalities. In Poland, mass demonstrations by women succeeded in turning back proposed legislation prohibiting abortions. The outcome of the U.S. elections in late 2016 raised grave concerns about the future of American women’s access to abortion, which was already limited by stringent regulations and funding restrictions. We chose the title ‘‘Abortion in Context’’ to signal that we sought to publish work that moved beyond examining abortion as a ‘‘stress experience’’ encountered by individual women or as a possible precursor of mental illness. Our goal was to assemble a set of articles that would prompt readers to think critically about practices and discourses surrounding abortion. We further hoped to include work that would address the meanings and practices of abortion in the global South and among minoritized groups in the global North. We were pleased by the enthusiastic response to our Call for Papers. We note that Eklund and Purewal (2017, this issue) address abortion in China and India. Thoradeniya’s (2017, this issue) review of Abortion in Asia (Whittaker, 2010) provides a glimpse of the complex and varied practices, policies, and experiences of abortion in parts of South and Southeast Asia. Chiweshe, Mavuso, and Macleod (whose work will appear in Part 2 of the Special Issue) take up abortion in South Africa and Zimbabwe. Le Grice and Braun (whose work will also appear in Part 2), examine Maori perspectives on abortion. In this Part 1 of the Special Issue, we present work that locates abortion practices and policies in legal, social, and healthcare contexts. Women’s efforts to exercise agency with regard to bodily integrity in the context of pregnancy are shaped most obviously by the legal regulations in the jurisdictions where they live, but they are also shaped by social and cultural issues, biotechnological advances, and healthcare systems. The articles offer detailed examinations of some of these complex contextual framings of abortion.
- Full Text:
- Date Issued: 2017
Geochemical constraints on coupled assimilation and fractional crystallization involving upper crustal compositions and continental tholeiitic magma
- Authors: Marsh, Julian S
- Date: 2002
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140432 , vital:37888 , https://doi.org/10.1016/0012-821X(89)90021-6
- Description: The commonly analyzed trace elements in tholeiites can be subdivided into three groups depending on their sense of enrichment or depletion in upper continental crust in relation to fractional crystallization. Lithophile incompatible elements are enriched in crustal rocks and by fractional crystallization, whereas compatible transition elements such as Ni and Cr are depleted. A small third group comprising Ti, V, Fe, and sometimes P, enrich with crystallization but are depleted in the crust.
- Full Text: false
- Date Issued: 2002
- Authors: Marsh, Julian S
- Date: 2002
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140432 , vital:37888 , https://doi.org/10.1016/0012-821X(89)90021-6
- Description: The commonly analyzed trace elements in tholeiites can be subdivided into three groups depending on their sense of enrichment or depletion in upper continental crust in relation to fractional crystallization. Lithophile incompatible elements are enriched in crustal rocks and by fractional crystallization, whereas compatible transition elements such as Ni and Cr are depleted. A small third group comprising Ti, V, Fe, and sometimes P, enrich with crystallization but are depleted in the crust.
- Full Text: false
- Date Issued: 2002
Synergies between research organisations and the wider community in enhancing weed biological control in South Africa
- Martin, Grant D, Hill, Martin P, Coetzee, Julie A, Weaver, Kim N, Hill, Jaclyn M
- Authors: Martin, Grant D , Hill, Martin P , Coetzee, Julie A , Weaver, Kim N , Hill, Jaclyn M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68452 , vital:29258 , https://doi.org/10.1007/s10526-017-9846-4
- Description: Biological control offers a cost effective and ecologically sustainable tool for the management of invasive alien plants. Its implementation, however, has historically been slow and poorly co-ordinated. In South Africa, as in many other countries, most aspects of biological control programmes were done by researchers, but from 1995 onwards, with the advent of the Working for Water Programme, a more inclusive approach to biological control has been adopted. In this paper, we report on the development of community-based biological control implementation programmes in South Africa, after 1995, and highlight a number of initiatives, including employing persons with disabilities at mass-rearing facilities and in particular, we outline a suite of educational and outreach programmes for the general public and for schools, which have increased capacity, education and employment in the field of weed biological control.
- Full Text:
- Date Issued: 2018
- Authors: Martin, Grant D , Hill, Martin P , Coetzee, Julie A , Weaver, Kim N , Hill, Jaclyn M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68452 , vital:29258 , https://doi.org/10.1007/s10526-017-9846-4
- Description: Biological control offers a cost effective and ecologically sustainable tool for the management of invasive alien plants. Its implementation, however, has historically been slow and poorly co-ordinated. In South Africa, as in many other countries, most aspects of biological control programmes were done by researchers, but from 1995 onwards, with the advent of the Working for Water Programme, a more inclusive approach to biological control has been adopted. In this paper, we report on the development of community-based biological control implementation programmes in South Africa, after 1995, and highlight a number of initiatives, including employing persons with disabilities at mass-rearing facilities and in particular, we outline a suite of educational and outreach programmes for the general public and for schools, which have increased capacity, education and employment in the field of weed biological control.
- Full Text:
- Date Issued: 2018
Competition between two aquatic macrophytes, Lagarosiphon major (Ridley) Moss (Hydrocharitaceae) and Myriophyllum spicatum Linnaeus (Haloragaceae) as influenced by substrate sediment and nutrients
- Martin, Grant D, Coetzee, Julie A
- Authors: Martin, Grant D , Coetzee, Julie A
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76925 , vital:30641 , https://doi.org/10.1016/j.aquabot.2013.11.001
- Description: Competition between two globally economic and ecologically important submerged aquatic macrophytes, Lagarosiphon major (Rid.) Moss ex Wager and Myriophyllum spicatum L., was studied in response to growing in different substrate nutrient and sediment treatments. Addition series experiments were conducted with mixed plantings of L. major and M. spicatum grown under two soil nutrient concentrations (high vs. low) and two sediment treatments (sand vs. loam). Competitive ability of the plants was determined using an inverse linear model of the total dry weights as the yield variable. In high nutrient sediment treatments, L. major was the stronger competitor relative to M. spicatum, with one L. major plant being competitively equivalent to 2.5 M. spicatum plants in terms of their respective ability to reduce L. major biomass. In the loam sediment treatments, L. major was an even stronger competitor relative to M. spicatum with one L. major being equivalent to 10 M. spicatum plants. Additionally, L. major had a faster relative growth rate (RGR) than M. spicatum when grown in mixed cultures, a loam sediment type and at both high and low planting densities. The results indicated that L. major is a superior competitor to M. spicatum and that both nutrient and sediment conditions significantly affect the competitive ability of both species. The results contribute to the understanding of competition between submerged invasive macrophytes, and provide insight into the establishment and spread of invasive submerged macrophytes.
- Full Text:
- Date Issued: 2014
- Authors: Martin, Grant D , Coetzee, Julie A
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76925 , vital:30641 , https://doi.org/10.1016/j.aquabot.2013.11.001
- Description: Competition between two globally economic and ecologically important submerged aquatic macrophytes, Lagarosiphon major (Rid.) Moss ex Wager and Myriophyllum spicatum L., was studied in response to growing in different substrate nutrient and sediment treatments. Addition series experiments were conducted with mixed plantings of L. major and M. spicatum grown under two soil nutrient concentrations (high vs. low) and two sediment treatments (sand vs. loam). Competitive ability of the plants was determined using an inverse linear model of the total dry weights as the yield variable. In high nutrient sediment treatments, L. major was the stronger competitor relative to M. spicatum, with one L. major plant being competitively equivalent to 2.5 M. spicatum plants in terms of their respective ability to reduce L. major biomass. In the loam sediment treatments, L. major was an even stronger competitor relative to M. spicatum with one L. major being equivalent to 10 M. spicatum plants. Additionally, L. major had a faster relative growth rate (RGR) than M. spicatum when grown in mixed cultures, a loam sediment type and at both high and low planting densities. The results indicated that L. major is a superior competitor to M. spicatum and that both nutrient and sediment conditions significantly affect the competitive ability of both species. The results contribute to the understanding of competition between submerged invasive macrophytes, and provide insight into the establishment and spread of invasive submerged macrophytes.
- Full Text:
- Date Issued: 2014
Local use and knowledge of Hyphaene coriacea and Phoenix reclinata in Zitundo area, southern Mozambique:
- Martins, Angelina R O, Shackleton, Charlie M
- Authors: Martins, Angelina R O , Shackleton, Charlie M
- Date: 2021
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/175801 , vital:42625 , https://doi.org/10.1016/j.sajb.2020.12.011
- Description: Hyphaene coriacea and Phoenix reclinata are two abundant palm species in the Maputaland coastal plains of southern Mozambique. They provide an array of subsistence and commercial non- timber forest products. This research characterizes the ethnobotanical knowledge and uses of these species. Using structured interviews we assessed the knowledge, past and current uses, cultural importance and the determinants of the knowledge and current uses of these species. The knowledge about the uses of these two palms is widespread, however only 32% of respondents are engaged in palm exploitation. Thirteen palm products are used in the area with palm wine production from the sap of both species being the dominant activity, followed by broom production.
- Full Text:
- Date Issued: 2021
- Authors: Martins, Angelina R O , Shackleton, Charlie M
- Date: 2021
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/175801 , vital:42625 , https://doi.org/10.1016/j.sajb.2020.12.011
- Description: Hyphaene coriacea and Phoenix reclinata are two abundant palm species in the Maputaland coastal plains of southern Mozambique. They provide an array of subsistence and commercial non- timber forest products. This research characterizes the ethnobotanical knowledge and uses of these species. Using structured interviews we assessed the knowledge, past and current uses, cultural importance and the determinants of the knowledge and current uses of these species. The knowledge about the uses of these two palms is widespread, however only 32% of respondents are engaged in palm exploitation. Thirteen palm products are used in the area with palm wine production from the sap of both species being the dominant activity, followed by broom production.
- Full Text:
- Date Issued: 2021
Aphid (Sitobion yakini) investigation shows thin-walled sieve tubes in barley (Hordeum vulgare L) to be more functional than thick-walled sieve tubes
- Matsiliza, Balbalwa, Botha, Christiaan E J
- Authors: Matsiliza, Balbalwa , Botha, Christiaan E J
- Date: 2002
- Language: English
- Type: Article
- Identifier: vital:6526 , http://hdl.handle.net/10962/d1005960
- Description: Barley, like most other grasses that have been studied, contains two kinds of sieve tube. The first formed are called thinwalled sieve tubes because of their thin wall compared to the late-formed, and are associated with companion cells. The late-formed are thick-walled sieve tubes, which differentiate next to the metaxylem vessels and lack companion cells. Aphid (Sitobion yakini (Eastop) feeding was studied using light microscopy to determine if they preferentially feed from thin- or thick-walled sieve tubes in the barley leaf. Penetration of the stylets through the leaf epidermis and mesophyll was largely intercellular, becoming partly intercellular and, partly, intracellular inside the vascular bundle. Sixteen of 19 pairs of stylets (84%), and 293 of 317 (92%) stylet tracks terminated at the thin-walled sieve tubes, suggesting that Sitobion yakini feeds preferentially on the thin-walled sieve tubes which seem to be more attractive to the aphid. These thin-walled sieve tubes are thus probably the most functional in terms of phloem loading and transport.
- Full Text:
- Date Issued: 2002
- Authors: Matsiliza, Balbalwa , Botha, Christiaan E J
- Date: 2002
- Language: English
- Type: Article
- Identifier: vital:6526 , http://hdl.handle.net/10962/d1005960
- Description: Barley, like most other grasses that have been studied, contains two kinds of sieve tube. The first formed are called thinwalled sieve tubes because of their thin wall compared to the late-formed, and are associated with companion cells. The late-formed are thick-walled sieve tubes, which differentiate next to the metaxylem vessels and lack companion cells. Aphid (Sitobion yakini (Eastop) feeding was studied using light microscopy to determine if they preferentially feed from thin- or thick-walled sieve tubes in the barley leaf. Penetration of the stylets through the leaf epidermis and mesophyll was largely intercellular, becoming partly intercellular and, partly, intracellular inside the vascular bundle. Sixteen of 19 pairs of stylets (84%), and 293 of 317 (92%) stylet tracks terminated at the thin-walled sieve tubes, suggesting that Sitobion yakini feeds preferentially on the thin-walled sieve tubes which seem to be more attractive to the aphid. These thin-walled sieve tubes are thus probably the most functional in terms of phloem loading and transport.
- Full Text:
- Date Issued: 2002
The ambivalence of African elitehood:
- Authors: Matthews, Sally
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142442 , vital:38080 , DOI: 10.1177/0021909609357416
- Description: Recent discussions in South Africa about the role of the so-called patriotic bourgeoisie highlight the much debated question of what role elite Africans can and ought to play in the upliftment of the poor. Those supporting the notion of a patriotic bourgeoisie believe that national or racial solidarity is sufficient to allow privileged Africans to act in the interests of their poorer fellow citizens. However, a reconsideration of an older discussion of African elitehood, that of Amilcar Cabral, suggests that something more may be needed before elites can act in the interests of the poor. Cabral argues that elites need to renounce their privilege and to live and struggle alongside the poor if pro-poor societal transformation is to be achieved. While Cabral may be right that shared racial or national identity is insufficient for elite solidarity with the poor, he does not consider all the complexities that arise when elites actually try to work with and for the poor. A consideration of the experiences of a long-standing Senegalese NGO reveal some of these complexities and suggest that any attempt by African elites to engage meaningfully in the upliftment of the poor, will inevitably involve continuous and difficult negotiation between paternalism and naïve egalitarianism.
- Full Text:
- Date Issued: 2010
- Authors: Matthews, Sally
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142442 , vital:38080 , DOI: 10.1177/0021909609357416
- Description: Recent discussions in South Africa about the role of the so-called patriotic bourgeoisie highlight the much debated question of what role elite Africans can and ought to play in the upliftment of the poor. Those supporting the notion of a patriotic bourgeoisie believe that national or racial solidarity is sufficient to allow privileged Africans to act in the interests of their poorer fellow citizens. However, a reconsideration of an older discussion of African elitehood, that of Amilcar Cabral, suggests that something more may be needed before elites can act in the interests of the poor. Cabral argues that elites need to renounce their privilege and to live and struggle alongside the poor if pro-poor societal transformation is to be achieved. While Cabral may be right that shared racial or national identity is insufficient for elite solidarity with the poor, he does not consider all the complexities that arise when elites actually try to work with and for the poor. A consideration of the experiences of a long-standing Senegalese NGO reveal some of these complexities and suggest that any attempt by African elites to engage meaningfully in the upliftment of the poor, will inevitably involve continuous and difficult negotiation between paternalism and naïve egalitarianism.
- Full Text:
- Date Issued: 2010
HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature
- Mattison, Stacey A, Blatch, Gregory L, Edkins, Adrienne L
- Authors: Mattison, Stacey A , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66278 , vital:28928 , https://doi.org/10.1007/s12192-016-0755-8
- Description: publisher version , The Hsp70/Hsp90 organising protein (HOP) is a co-chaperone essential for client protein transfer from Hsp70 to Hsp90 within the Hsp90 chaperone machine. Although HOP is upregulated in various cancers, there is limited information from in vitro studies on how HOP expression is regulated in cancer. The main objective of this study was to identify the HOP promoter and investigate its activity in cancerous cells. Bioinformatic analysis of the -2500 to +16 bp region of the HOP gene identified a large CpG island and a range of putative cis-elements. Many of the cis-elements were potentially bound by transcription factors which are activated by oncogenic pathways. Luciferase reporter assays demonstrated that the upstream region of the HOP gene contains an active promoter in vitro. Truncation of this region suggested that the core HOP promoter region was -855 to +16 bp. HOP promoter activity was highest in Hs578T, HEK293T and SV40- transformed MEF1 cell lines which expressed mutant or inactive p53. In a mutant p53 background, expression of wild-type p53 led to a reduction in promoter activity, while inhibition of wild-type p53 in HeLa cells increased HOP promoter activity. Additionally, in Hs578T and HEK293T cell lines containing inactive p53, expression of HRAS increased HOP promoter activity. However, HRAS activation of the HOP promoter was inhibited by p53 overexpression. These findings suggest for the first time that HOP expression in cancer may be regulated by both RAS activation and p53 inhibition. Taken together, these data suggest that HOP may be part of the cancer gene signature induced by a combination of mutant p53 and mutated RAS that is associated with cellular transformation.
- Full Text: false
- Date Issued: 2018
- Authors: Mattison, Stacey A , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66278 , vital:28928 , https://doi.org/10.1007/s12192-016-0755-8
- Description: publisher version , The Hsp70/Hsp90 organising protein (HOP) is a co-chaperone essential for client protein transfer from Hsp70 to Hsp90 within the Hsp90 chaperone machine. Although HOP is upregulated in various cancers, there is limited information from in vitro studies on how HOP expression is regulated in cancer. The main objective of this study was to identify the HOP promoter and investigate its activity in cancerous cells. Bioinformatic analysis of the -2500 to +16 bp region of the HOP gene identified a large CpG island and a range of putative cis-elements. Many of the cis-elements were potentially bound by transcription factors which are activated by oncogenic pathways. Luciferase reporter assays demonstrated that the upstream region of the HOP gene contains an active promoter in vitro. Truncation of this region suggested that the core HOP promoter region was -855 to +16 bp. HOP promoter activity was highest in Hs578T, HEK293T and SV40- transformed MEF1 cell lines which expressed mutant or inactive p53. In a mutant p53 background, expression of wild-type p53 led to a reduction in promoter activity, while inhibition of wild-type p53 in HeLa cells increased HOP promoter activity. Additionally, in Hs578T and HEK293T cell lines containing inactive p53, expression of HRAS increased HOP promoter activity. However, HRAS activation of the HOP promoter was inhibited by p53 overexpression. These findings suggest for the first time that HOP expression in cancer may be regulated by both RAS activation and p53 inhibition. Taken together, these data suggest that HOP may be part of the cancer gene signature induced by a combination of mutant p53 and mutated RAS that is associated with cellular transformation.
- Full Text: false
- Date Issued: 2018
A Case Study of Two Selected Teachers as they Integrated Dynamic Geometry Software as a Visualisation Tool in Teaching Geometry:
- Mavani, Deepak, Mavani, Beena, Schäfer, Marc
- Authors: Mavani, Deepak , Mavani, Beena , Schäfer, Marc
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141076 , vital:37942 , https://doi.org/10.1080/18117295.2018.1522716
- Description: This paper reports on an aspect of a larger research study conceptualised within a teacher development project in Mthatha, Eastern Cape Province. The project was initiated with the objective to develop appropriate skills to use dynamic geometry software (DGS) effectively and strategically as a teaching and learning tool for mathematics. The study reported in this paper aims specifically to ascertain how selected mathematics teachers integrated co-developed technologically aided visualisation tools in the observed lessons. The case study involved two teachers from different schools. The data sources were the classroom observations followed by stimulated reflective interviews with the teachers. The data were analysed to study the use of DGS visualisation tools in relation to Kilpatrick’s framework of teaching proficiency.
- Full Text:
- Date Issued: 2018
- Authors: Mavani, Deepak , Mavani, Beena , Schäfer, Marc
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141076 , vital:37942 , https://doi.org/10.1080/18117295.2018.1522716
- Description: This paper reports on an aspect of a larger research study conceptualised within a teacher development project in Mthatha, Eastern Cape Province. The project was initiated with the objective to develop appropriate skills to use dynamic geometry software (DGS) effectively and strategically as a teaching and learning tool for mathematics. The study reported in this paper aims specifically to ascertain how selected mathematics teachers integrated co-developed technologically aided visualisation tools in the observed lessons. The case study involved two teachers from different schools. The data sources were the classroom observations followed by stimulated reflective interviews with the teachers. The data were analysed to study the use of DGS visualisation tools in relation to Kilpatrick’s framework of teaching proficiency.
- Full Text:
- Date Issued: 2018
Perceptions of Chinese and Tanzanian employees regarding intercultural collaboration
- Mayer, Claude-Hélène, Boness, Christian M, Louw, Lynette
- Authors: Mayer, Claude-Hélène , Boness, Christian M , Louw, Lynette
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125542 , vital:35793 , https://doi.org/10.4102/sajhrm.v15i0.921
- Description: China’s impact and role in the development of countries in Africa, primarily through foreign direct investments and grants to governments, has increased in the past decade. For instance, the total value of trade between China and Africa was USD198.5 billion in 2012, increasing to USD385bn in 2015 (African Economic Outlook, 2014, p. 76). A growing number of Chinese private and governmental organisations are investing in southern Africa. In Tanzanian contexts, this leads to a close collaboration of Chinese and Tanzanian employees (African Economic Outlook, 2014). These collaborations in Chinese organisations in Tanzania lead to intercultural communication situations and to new intercultural experiences and perceptions.
- Full Text:
- Date Issued: 2017
- Authors: Mayer, Claude-Hélène , Boness, Christian M , Louw, Lynette
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125542 , vital:35793 , https://doi.org/10.4102/sajhrm.v15i0.921
- Description: China’s impact and role in the development of countries in Africa, primarily through foreign direct investments and grants to governments, has increased in the past decade. For instance, the total value of trade between China and Africa was USD198.5 billion in 2012, increasing to USD385bn in 2015 (African Economic Outlook, 2014, p. 76). A growing number of Chinese private and governmental organisations are investing in southern Africa. In Tanzanian contexts, this leads to a close collaboration of Chinese and Tanzanian employees (African Economic Outlook, 2014). These collaborations in Chinese organisations in Tanzania lead to intercultural communication situations and to new intercultural experiences and perceptions.
- Full Text:
- Date Issued: 2017
The great arch of unimagined bridges: integrative play therapy with an abused child
- Authors: McDermott, R
- Date: 2005
- Language: English
- Type: text , Article
- Identifier: vital:6272 , http://hdl.handle.net/10962/d1008272
- Description: This case study describes the early phases of integrative, long-term psychotherapy undertaken with a child subjected to chronic domestic trauma including violence, alcohol abuse, neglect, abandonment, and bereavement resulting from HIV/AIDS. Recent statistics on the prevalence of violent trauma, domestic abuse and HIV/AIDS in South Africa are reviewed, as are principles of trauma intervention that have been established across a range of psychotherapeutic modalities. Following from integrative trauma work undertaken locally, this therapeutic process acknowledges both indigenous and western frameworks of meaning, the latter most heavily informed by principles of analytical psychology. Selected aspects of the therapy are discussed in light of both perspectives, with reference to the child’s process of recovery. This paper seeks to add support to practised and published local work in which a range of possible healing practices, meanings, and experience are taken into account. It is proposed that such integrative efforts contribute towards an evolving African psychotherapy.
- Full Text:
- Date Issued: 2005
- Authors: McDermott, R
- Date: 2005
- Language: English
- Type: text , Article
- Identifier: vital:6272 , http://hdl.handle.net/10962/d1008272
- Description: This case study describes the early phases of integrative, long-term psychotherapy undertaken with a child subjected to chronic domestic trauma including violence, alcohol abuse, neglect, abandonment, and bereavement resulting from HIV/AIDS. Recent statistics on the prevalence of violent trauma, domestic abuse and HIV/AIDS in South Africa are reviewed, as are principles of trauma intervention that have been established across a range of psychotherapeutic modalities. Following from integrative trauma work undertaken locally, this therapeutic process acknowledges both indigenous and western frameworks of meaning, the latter most heavily informed by principles of analytical psychology. Selected aspects of the therapy are discussed in light of both perspectives, with reference to the child’s process of recovery. This paper seeks to add support to practised and published local work in which a range of possible healing practices, meanings, and experience are taken into account. It is proposed that such integrative efforts contribute towards an evolving African psychotherapy.
- Full Text:
- Date Issued: 2005
Determining the daily spawning cycle of the chokka squid, Loligo reynaudii off the South African Coast
- Authors: Melo, Y , Sauer, Warwick H H
- Date: 2007
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124275 , vital:35588 , https://doi.10.1007/s11160-006-9034-6
- Description: The study investigated the duration and peak of the daily spawning cycle of the chokka squid Loligo reynaudii, and the possibility of estimating the spawning frequency by means of classification and grouping (by age) of postovulatory follicles. Post-ovulatory follicles were classified into three types: new, intermediate or old, based in part on the degree of resorption of the follicles determined from histological sections. Ovulation in this species appears to be a rapid process, seen by the occurrence of both mature oocytes and post-ovulatory follicles in partially spent ovaries. Results suggest that chokka squid present a diel timing of spawning, with successive periods of egg accumulation at night, interrupted by periods of active spawning during the day. The ovarian cycle for this species appears typical of serial spawners. During the spawning phase ovaries go through ripe, partially spent and recovering stages by undergoing a process of maturation, ovulation and redeveloping, where a new batch of advanced oocytes is recruited. The cycle typically appears to last between 24 and 36 h, and may depend on a number of factors such as environmental conditions and the presence of predators. The short-lived (about 14 h) nature of the post-ovulatory follicles precludes the calculation of the exact spawning interval and does not allow us to accurately predict the spawning frequency. Together with the degree of oviduct fullness they do however give a good indication of imminent or recent spawning.
- Full Text:
- Date Issued: 2007
- Authors: Melo, Y , Sauer, Warwick H H
- Date: 2007
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124275 , vital:35588 , https://doi.10.1007/s11160-006-9034-6
- Description: The study investigated the duration and peak of the daily spawning cycle of the chokka squid Loligo reynaudii, and the possibility of estimating the spawning frequency by means of classification and grouping (by age) of postovulatory follicles. Post-ovulatory follicles were classified into three types: new, intermediate or old, based in part on the degree of resorption of the follicles determined from histological sections. Ovulation in this species appears to be a rapid process, seen by the occurrence of both mature oocytes and post-ovulatory follicles in partially spent ovaries. Results suggest that chokka squid present a diel timing of spawning, with successive periods of egg accumulation at night, interrupted by periods of active spawning during the day. The ovarian cycle for this species appears typical of serial spawners. During the spawning phase ovaries go through ripe, partially spent and recovering stages by undergoing a process of maturation, ovulation and redeveloping, where a new batch of advanced oocytes is recruited. The cycle typically appears to last between 24 and 36 h, and may depend on a number of factors such as environmental conditions and the presence of predators. The short-lived (about 14 h) nature of the post-ovulatory follicles precludes the calculation of the exact spawning interval and does not allow us to accurately predict the spawning frequency. Together with the degree of oviduct fullness they do however give a good indication of imminent or recent spawning.
- Full Text:
- Date Issued: 2007
'The Area of a Triangle is 1800C’: an analysis of Learners' Idiosyncratic Geometry Responses through the Lenses of Vygotsky's Theory of Concept Formation
- Mhlolo, Michael K, Schäfer, Marc
- Authors: Mhlolo, Michael K , Schäfer, Marc
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141127 , vital:37946 , DOI: 10.1080/10288457.2013.826973
- Description: In this paper, we focus specifically on Vygotsky's theory of concept formation to gain initial insights into seemingly garbled and incoherent connections we observed in learners' responses to a geometry task. While acknowledging research that is supportive of the van Hiele model as being useful when analysing concept formation in geometry, in this paper we use empirical evidence to argue that today's geometry requires learners to reason with many tools which the van Hiele model does not seem to accommodate. Working with 470 written responses of 12–14-year-old learners to a geometry task, we then explored the potential of Vygotsky's theory of concept formation as an alternative framework. We conclude by discussing the paper's contribution both to theory and to classroom practice.
- Full Text:
- Date Issued: 2013
- Authors: Mhlolo, Michael K , Schäfer, Marc
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141127 , vital:37946 , DOI: 10.1080/10288457.2013.826973
- Description: In this paper, we focus specifically on Vygotsky's theory of concept formation to gain initial insights into seemingly garbled and incoherent connections we observed in learners' responses to a geometry task. While acknowledging research that is supportive of the van Hiele model as being useful when analysing concept formation in geometry, in this paper we use empirical evidence to argue that today's geometry requires learners to reason with many tools which the van Hiele model does not seem to accommodate. Working with 470 written responses of 12–14-year-old learners to a geometry task, we then explored the potential of Vygotsky's theory of concept formation as an alternative framework. We conclude by discussing the paper's contribution both to theory and to classroom practice.
- Full Text:
- Date Issued: 2013
Accounting 1A: ACC 111 & 111E
- Mnconywa, N, Mtshwelo, L, Lockyear, M
- Authors: Mnconywa, N , Mtshwelo, L , Lockyear, M
- Date: 2011-06
- Subjects: Accounting
- Language: English
- Type: Examination paper
- Identifier: vital:17419 , http://hdl.handle.net/10353/d1009788
- Description: Accounting 1A: ACC 111 & 111E, examination June 2011.
- Full Text: false
- Date Issued: 2011-06
- Authors: Mnconywa, N , Mtshwelo, L , Lockyear, M
- Date: 2011-06
- Subjects: Accounting
- Language: English
- Type: Examination paper
- Identifier: vital:17419 , http://hdl.handle.net/10353/d1009788
- Description: Accounting 1A: ACC 111 & 111E, examination June 2011.
- Full Text: false
- Date Issued: 2011-06
Development of a stability-indicating high performance liquid chromatographic method for the analysis of topiramate and dissolution rate testing in topiramate tablets
- Mohammadi, Ali, Rezanour, Nasrin, Ansari Dogaheh, M, Walker, Roderick B
- Authors: Mohammadi, Ali , Rezanour, Nasrin , Ansari Dogaheh, M , Walker, Roderick B
- Date: 2010
- Language: English
- Type: text , Article
- Identifier: vital:6412 , http://hdl.handle.net/10962/d1006507
- Description: A stability-indicating high performance liquid chromatographic(HPLC) method was developed and validated for the quantitation and dissolution determination of topiramate in tablet dosage forms. An isocratic separation was achieved using a phenyl column with a flow rate of 1 mL/min using UV detection at 264 nm. Topiramate has low UV absorbtivity and was subjected to derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl). The mobile phase for the separation consisted of acetonitrile: 50 mM sodium dihydrogen phosphate(NaH2PO4) containing 3 % v/v triethylamine (pH 2.8) in a 48:52 v/v ratio. Topiramate was subjected to oxidation, hydrolysis, photolysis and heat for the purposes of stress testing. Separation was achieved for the parent compound and all the degradation products in an overall analytical run time of approximately 15 min with the parent compound topiramate eluting at approximately 9.2 min. The method was linear over the concentration range of 1-100 μg/mL (r = 0.9996) with limits of quantitation and detection of 1 and 0.3 μg/mL, respectively.
- Full Text:
- Date Issued: 2010
- Authors: Mohammadi, Ali , Rezanour, Nasrin , Ansari Dogaheh, M , Walker, Roderick B
- Date: 2010
- Language: English
- Type: text , Article
- Identifier: vital:6412 , http://hdl.handle.net/10962/d1006507
- Description: A stability-indicating high performance liquid chromatographic(HPLC) method was developed and validated for the quantitation and dissolution determination of topiramate in tablet dosage forms. An isocratic separation was achieved using a phenyl column with a flow rate of 1 mL/min using UV detection at 264 nm. Topiramate has low UV absorbtivity and was subjected to derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl). The mobile phase for the separation consisted of acetonitrile: 50 mM sodium dihydrogen phosphate(NaH2PO4) containing 3 % v/v triethylamine (pH 2.8) in a 48:52 v/v ratio. Topiramate was subjected to oxidation, hydrolysis, photolysis and heat for the purposes of stress testing. Separation was achieved for the parent compound and all the degradation products in an overall analytical run time of approximately 15 min with the parent compound topiramate eluting at approximately 9.2 min. The method was linear over the concentration range of 1-100 μg/mL (r = 0.9996) with limits of quantitation and detection of 1 and 0.3 μg/mL, respectively.
- Full Text:
- Date Issued: 2010
The relationship between subjective well-being and domain satisfactions in South Africa
- Authors: Moller, Valerie , Saris, W E
- Date: 2001
- Language: English
- Type: Article
- Identifier: vital:7116 , http://hdl.handle.net/10962/d1010749 , http://dx.doi.org/10.1023/A:1010851412273
- Description: This paper examines the relationship between subjective well-being and domain satisfactions. In the past different models have been specified. The most commonly applied model is the bottom-up model in which domain satisfactions affect subjective well-being. The more recent top-down model suggests a reversed relationship. Finally there is the supposition that the correlations between these variables can be spurious due to the effect of personality characteristics. Empirical research has shown that different models are found for different domains and in different countries. Focussing on the effects of the domain satisfactions of finances, housing and social contacts it has been found that subjective well-being is mainly affected by satisfaction with social contacts in Western developed countries and by satisfaction with finances in East European countries. The question we should like to answer in this study is whether a similar pattern obtains for the factors which influence subjective well-being among the different race groups in South Africa. Interestingly, coloured people and Asians did indeed show the expected effects but the groups with the most extreme living conditions did not. Evaluation of life circumstances by black and white South Africans was determined by expectations for the future rather than by current living conditions. This surprising result is discussed in the light of the political situation in South Africa.
- Full Text:
- Date Issued: 2001
- Authors: Moller, Valerie , Saris, W E
- Date: 2001
- Language: English
- Type: Article
- Identifier: vital:7116 , http://hdl.handle.net/10962/d1010749 , http://dx.doi.org/10.1023/A:1010851412273
- Description: This paper examines the relationship between subjective well-being and domain satisfactions. In the past different models have been specified. The most commonly applied model is the bottom-up model in which domain satisfactions affect subjective well-being. The more recent top-down model suggests a reversed relationship. Finally there is the supposition that the correlations between these variables can be spurious due to the effect of personality characteristics. Empirical research has shown that different models are found for different domains and in different countries. Focussing on the effects of the domain satisfactions of finances, housing and social contacts it has been found that subjective well-being is mainly affected by satisfaction with social contacts in Western developed countries and by satisfaction with finances in East European countries. The question we should like to answer in this study is whether a similar pattern obtains for the factors which influence subjective well-being among the different race groups in South Africa. Interestingly, coloured people and Asians did indeed show the expected effects but the groups with the most extreme living conditions did not. Evaluation of life circumstances by black and white South Africans was determined by expectations for the future rather than by current living conditions. This surprising result is discussed in the light of the political situation in South Africa.
- Full Text:
- Date Issued: 2001
MMORPG: Towards a Sustainable Livelihood Model for Africa and Beyond
- Mostert, Andre, Kaschula, Russell H
- Authors: Mostert, Andre , Kaschula, Russell H
- Date: 2011
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/175212 , vital:42553 , ISBN ViNOrg 2011 , https://link.springer.com/chapter/10.1007/978-3-642-31800-9_4
- Description: The burgeoning worlds of massively multiplayer online role-playing games (MMORPG) coupled with increasing access to the internet is opening a new paradigmatic window for a number of disciplines. Many of these have been slow to take up the challenges associated with this emergent framework, due, in no small measure, to the perception that work and play are mutually exclusive. The dominance of this dichotomy contributed to the slow uptake of the potential for these virtual worlds to be harnessed in the fields of education and employment. This reticence was due in no small measure to the technophobia that tends to characterise the adoption of new technologies within fields that have customarily eschewed an embrace.
- Full Text:
- Date Issued: 2011
- Authors: Mostert, Andre , Kaschula, Russell H
- Date: 2011
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/175212 , vital:42553 , ISBN ViNOrg 2011 , https://link.springer.com/chapter/10.1007/978-3-642-31800-9_4
- Description: The burgeoning worlds of massively multiplayer online role-playing games (MMORPG) coupled with increasing access to the internet is opening a new paradigmatic window for a number of disciplines. Many of these have been slow to take up the challenges associated with this emergent framework, due, in no small measure, to the perception that work and play are mutually exclusive. The dominance of this dichotomy contributed to the slow uptake of the potential for these virtual worlds to be harnessed in the fields of education and employment. This reticence was due in no small measure to the technophobia that tends to characterise the adoption of new technologies within fields that have customarily eschewed an embrace.
- Full Text:
- Date Issued: 2011