Zimbabwe's Land Reform: myths and realities
- Authors: Helliker, Kirk D
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144710 , vital:38372 , DOI: 10.1080/02589001.2011.581502
- Description: Zimbabwe’s land reform is the first book on contemporary Zimbabwe that offers an empirically-rich and detailed account of redistributed farms that arose from ‘fasttrack’ land reform 10 years ago. In order to fully appreciate the significance of this book, it is necessary to outline briefly recent intellectual debates on Zimbabwe. Two main positions exist on Zimbabwean politics and society. The first position argues that the radical restructuring of agrarian relations (including undermining white agricultural capital and breaking up large commercial farms into smaller units) is a progressive tendency that has opened up opportunities for black small-scale farmers. Simultaneously, this position often underplays the existence of state restructuring of an authoritarian kind. The second position argues that land redistribution has dramatically undercut agricultural production thereby severely compromising food security for all Zimbabweans. It brings to the fore violent state action in instigating land occupations and in thwarting political opposition to ‘fast-track’.
- Full Text:
- Date Issued: 2011
- Authors: Helliker, Kirk D
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144710 , vital:38372 , DOI: 10.1080/02589001.2011.581502
- Description: Zimbabwe’s land reform is the first book on contemporary Zimbabwe that offers an empirically-rich and detailed account of redistributed farms that arose from ‘fasttrack’ land reform 10 years ago. In order to fully appreciate the significance of this book, it is necessary to outline briefly recent intellectual debates on Zimbabwe. Two main positions exist on Zimbabwean politics and society. The first position argues that the radical restructuring of agrarian relations (including undermining white agricultural capital and breaking up large commercial farms into smaller units) is a progressive tendency that has opened up opportunities for black small-scale farmers. Simultaneously, this position often underplays the existence of state restructuring of an authoritarian kind. The second position argues that land redistribution has dramatically undercut agricultural production thereby severely compromising food security for all Zimbabweans. It brings to the fore violent state action in instigating land occupations and in thwarting political opposition to ‘fast-track’.
- Full Text:
- Date Issued: 2011
JM Coetzee's Disgrace: a reader's guide, and: JM Coetzee's austerities
- Authors: Marais, Mike
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144231 , vital:38323 , DOI: 10.2979/reseafrilite.42.4.135
- Description: Like all of the other publications in the series of which it forms a part, Andrew van der Vlies's Disgrace: A Reader's Guide conforms to a set format: a preface, followed by biographical information on the novelist and the context in which he or she wrote the text concerned, and then a longer section comprising a paraphrase and discussion of the work and its reception, together with suggestions for further reading. Despite these structural constraints, van der Vlies provides a very fine introduction to Disgrace in this volume. Readers will find especially insightful his treatment of Coetzee's preoccupation with alterity, and the responsibility, both ethical and aesthetic, that such otherness exacts. One very slight criticism I have of the monograph is that it could have contained more references to discussions of Coetzee's use of narrative point of view in its list of recommended reading. (James Meffan and Kim Worthington's examination of the ambivalent relationship between David Lurie and the narrator's voice comes to mind here, for instance.) Having said this, however, I have little doubt that van der Vlies's guide will prove a useful and comprehensive introduction to Disgrace in university programs.
- Full Text:
- Date Issued: 2011
- Authors: Marais, Mike
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/144231 , vital:38323 , DOI: 10.2979/reseafrilite.42.4.135
- Description: Like all of the other publications in the series of which it forms a part, Andrew van der Vlies's Disgrace: A Reader's Guide conforms to a set format: a preface, followed by biographical information on the novelist and the context in which he or she wrote the text concerned, and then a longer section comprising a paraphrase and discussion of the work and its reception, together with suggestions for further reading. Despite these structural constraints, van der Vlies provides a very fine introduction to Disgrace in this volume. Readers will find especially insightful his treatment of Coetzee's preoccupation with alterity, and the responsibility, both ethical and aesthetic, that such otherness exacts. One very slight criticism I have of the monograph is that it could have contained more references to discussions of Coetzee's use of narrative point of view in its list of recommended reading. (James Meffan and Kim Worthington's examination of the ambivalent relationship between David Lurie and the narrator's voice comes to mind here, for instance.) Having said this, however, I have little doubt that van der Vlies's guide will prove a useful and comprehensive introduction to Disgrace in university programs.
- Full Text:
- Date Issued: 2011
Voltammetry and electrochemical impedance spectroscopy of gold electrodes modified with CdTe quantum dots and their conjugates with nickel tetraamino phthalocyanine
- Khene, Samson, Moeno, Sharon, Nyokong, Tebello
- Authors: Khene, Samson , Moeno, Sharon , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247187 , vital:51554 , xlink:href="https://doi.org/10.1016/j.poly.2011.06.002"
- Description: This work reports on the synthesis of conjugates of cadmium telluride quantum dots (CdTe-QDs) caped with thioglycolic acid and peripherally substituted nickel tetraamino phthalocyanine (NiTAPc) complex. The conjugates are characterized using cyclic (CV) and differential pulse (DPV) voltammetries, electrochemical impedance spectroscopy, X-ray powder diffraction, infrared spectroscopy, Raman spectroscopy, atomic force microscopy and time correlated single photon counting. CV and DPV show that NiTAPc stabilizes the CdTe QDs against oxidation to metallic products.
- Full Text:
- Date Issued: 2011
- Authors: Khene, Samson , Moeno, Sharon , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247187 , vital:51554 , xlink:href="https://doi.org/10.1016/j.poly.2011.06.002"
- Description: This work reports on the synthesis of conjugates of cadmium telluride quantum dots (CdTe-QDs) caped with thioglycolic acid and peripherally substituted nickel tetraamino phthalocyanine (NiTAPc) complex. The conjugates are characterized using cyclic (CV) and differential pulse (DPV) voltammetries, electrochemical impedance spectroscopy, X-ray powder diffraction, infrared spectroscopy, Raman spectroscopy, atomic force microscopy and time correlated single photon counting. CV and DPV show that NiTAPc stabilizes the CdTe QDs against oxidation to metallic products.
- Full Text:
- Date Issued: 2011
Synthesis, characterization and application of monocarboxy-phthalocyanine-single walled carbon nanotube conjugates in electrocatalysis
- Mugadza, Tawanda, Nyokong, Tebello
- Authors: Mugadza, Tawanda , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247399 , vital:51577 , xlink:href="https://doi.org/10.1016/j.poly.2011.04.020"
- Description: In this paper we report on the synthesis, characterization and use of monocarboxy-phthalocyanine-single walled carbon nanotube conjugates in the electrocatalysis of amitrole and diuron. UV–Vis, FTIR and XRD spectroscopies were used in the characterization of cobalt(II)-tris(benzyl-mercapto)-mono(carboxyphenoxy)-phthalocyanine conjugates (CoMCPc–PA-SWCNT(linked)), while AFM was used to show changes in surface morphologies of the modified electrodes. Cyclic voltammetry and chronoamperometry were used for the electrocatalytic oxidation of amitrole and diuron on the modified glassy carbon electrode. The catalytic rate constants for amitrole and diuron were found to be 1.83 × 106 and 1.99 × 106 M−1 s−1, respectively. The linear range for both was 1.0 × 10−5–2.0 × 10−4 M, with sensitivities of 5.10 and 3.70 A mol−1 L cm−2 for amitrole and diuron, respectively. The limits of detection were estimated to be 0.14 and 0.20 μM for amitrole and diuron, respectively, using the 3δ notation.
- Full Text:
- Date Issued: 2011
- Authors: Mugadza, Tawanda , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247399 , vital:51577 , xlink:href="https://doi.org/10.1016/j.poly.2011.04.020"
- Description: In this paper we report on the synthesis, characterization and use of monocarboxy-phthalocyanine-single walled carbon nanotube conjugates in the electrocatalysis of amitrole and diuron. UV–Vis, FTIR and XRD spectroscopies were used in the characterization of cobalt(II)-tris(benzyl-mercapto)-mono(carboxyphenoxy)-phthalocyanine conjugates (CoMCPc–PA-SWCNT(linked)), while AFM was used to show changes in surface morphologies of the modified electrodes. Cyclic voltammetry and chronoamperometry were used for the electrocatalytic oxidation of amitrole and diuron on the modified glassy carbon electrode. The catalytic rate constants for amitrole and diuron were found to be 1.83 × 106 and 1.99 × 106 M−1 s−1, respectively. The linear range for both was 1.0 × 10−5–2.0 × 10−4 M, with sensitivities of 5.10 and 3.70 A mol−1 L cm−2 for amitrole and diuron, respectively. The limits of detection were estimated to be 0.14 and 0.20 μM for amitrole and diuron, respectively, using the 3δ notation.
- Full Text:
- Date Issued: 2011
The both-and edition:
- Authors: Garman, Anthea
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158828 , vital:40232 , https://hdl.handle.net/10520/EJC139379
- Description: This 30th edition of Rhodes Journalism Review is timed and themed for the 2nd World Journalism Education Congress which the School of Journalism and Media Studies is hosting at Rhodes University in Grahamstown from 5 to 7 July.
- Full Text:
- Date Issued: 2011
- Authors: Garman, Anthea
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158828 , vital:40232 , https://hdl.handle.net/10520/EJC139379
- Description: This 30th edition of Rhodes Journalism Review is timed and themed for the 2nd World Journalism Education Congress which the School of Journalism and Media Studies is hosting at Rhodes University in Grahamstown from 5 to 7 July.
- Full Text:
- Date Issued: 2011
MMORPG: Towards a Sustainable Livelihood Model for Africa and Beyond
- Mostert, Andre, Kaschula, Russell H
- Authors: Mostert, Andre , Kaschula, Russell H
- Date: 2011
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/175212 , vital:42553 , ISBN ViNOrg 2011 , https://link.springer.com/chapter/10.1007/978-3-642-31800-9_4
- Description: The burgeoning worlds of massively multiplayer online role-playing games (MMORPG) coupled with increasing access to the internet is opening a new paradigmatic window for a number of disciplines. Many of these have been slow to take up the challenges associated with this emergent framework, due, in no small measure, to the perception that work and play are mutually exclusive. The dominance of this dichotomy contributed to the slow uptake of the potential for these virtual worlds to be harnessed in the fields of education and employment. This reticence was due in no small measure to the technophobia that tends to characterise the adoption of new technologies within fields that have customarily eschewed an embrace.
- Full Text:
- Date Issued: 2011
- Authors: Mostert, Andre , Kaschula, Russell H
- Date: 2011
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/175212 , vital:42553 , ISBN ViNOrg 2011 , https://link.springer.com/chapter/10.1007/978-3-642-31800-9_4
- Description: The burgeoning worlds of massively multiplayer online role-playing games (MMORPG) coupled with increasing access to the internet is opening a new paradigmatic window for a number of disciplines. Many of these have been slow to take up the challenges associated with this emergent framework, due, in no small measure, to the perception that work and play are mutually exclusive. The dominance of this dichotomy contributed to the slow uptake of the potential for these virtual worlds to be harnessed in the fields of education and employment. This reticence was due in no small measure to the technophobia that tends to characterise the adoption of new technologies within fields that have customarily eschewed an embrace.
- Full Text:
- Date Issued: 2011
The contribution made by Mr Justice EF Watermeyer to South African tax jurisprudence
- Authors: Thackwell, Robert Colin
- Date: 2011
- Language: English
- Type: text , Thesis , Masters , MCom
- Identifier: vital:881 , http://hdl.handle.net/10962/d1001635
- Description: The objective of this thesis is to highlight the colossal contributions made by the late Justice Watermeyer to South African tax jurisprudence. His contributions are viewed from a practical application point of view as well as from a statutory interpretative perspective. The style and technique with which he delivered his judgments are also considered to be a contribution in their own right. The core of this thesis is the analysis of seven of Justice Watermeyer‟s most influential judgments. The development and application of the principle or principles developed in each of these seven judgments is then traced chronologically through case law up until recent judgments. It is most notable that each and every phrase contained in section 11(a) of the Income Tax Act has been interpreted by Justice Watermeyer. These interpretations are still viewed as correct statements of the applicable law and will continue to be referred to on a regular basis given the fact that section 11(a) is one of the most widely contested provisions in the Income Tax Act. Several references to his approach to statutory interpretation are made through the course of the case analyses. Whilst significant evidence of a purposive oriented approach to interpretation appears in some judgments, such evidence is lacking in others. An absolute or conclusive submission in terms of his approach to statutory interpretation is not sufficiently supported. His style of judgment is also referred to and commented on, with particular focus placed on his use of illustrative examples. The contribution to South African tax law by Justice Watermeyer is found to be nothing short of enormous. He was and continues to be influential with respect to section 11(a),the definition of gross income in section 1, common law principles of tax avoidance as well as the interpretation of statutory laws of tax avoidance. It is anticipated that some of his interpretations with respect to statutory rules of tax avoidance will be referred to when the relatively new anti-avoidance provisions become the subject of litigation.
- Full Text:
- Date Issued: 2011
- Authors: Thackwell, Robert Colin
- Date: 2011
- Language: English
- Type: text , Thesis , Masters , MCom
- Identifier: vital:881 , http://hdl.handle.net/10962/d1001635
- Description: The objective of this thesis is to highlight the colossal contributions made by the late Justice Watermeyer to South African tax jurisprudence. His contributions are viewed from a practical application point of view as well as from a statutory interpretative perspective. The style and technique with which he delivered his judgments are also considered to be a contribution in their own right. The core of this thesis is the analysis of seven of Justice Watermeyer‟s most influential judgments. The development and application of the principle or principles developed in each of these seven judgments is then traced chronologically through case law up until recent judgments. It is most notable that each and every phrase contained in section 11(a) of the Income Tax Act has been interpreted by Justice Watermeyer. These interpretations are still viewed as correct statements of the applicable law and will continue to be referred to on a regular basis given the fact that section 11(a) is one of the most widely contested provisions in the Income Tax Act. Several references to his approach to statutory interpretation are made through the course of the case analyses. Whilst significant evidence of a purposive oriented approach to interpretation appears in some judgments, such evidence is lacking in others. An absolute or conclusive submission in terms of his approach to statutory interpretation is not sufficiently supported. His style of judgment is also referred to and commented on, with particular focus placed on his use of illustrative examples. The contribution to South African tax law by Justice Watermeyer is found to be nothing short of enormous. He was and continues to be influential with respect to section 11(a),the definition of gross income in section 1, common law principles of tax avoidance as well as the interpretation of statutory laws of tax avoidance. It is anticipated that some of his interpretations with respect to statutory rules of tax avoidance will be referred to when the relatively new anti-avoidance provisions become the subject of litigation.
- Full Text:
- Date Issued: 2011
Phototransformation of 4-nitrophenol using Pd phthalocyanines supported on single walled carbon nanotubes
- Ogunbayo, Taofeek B, Nyokong, Tebello
- Authors: Ogunbayo, Taofeek B , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247800 , vital:51619 , xlink:href="https://doi.org/10.1016/j.molcata.2011.01.016"
- Description: Adsorption of palladium phthalocyanines complexes on single walled carbon nanotubes was carried out. The resulting composites were employed as catalysts for heterogeneous photocatalytic oxidation of 4-nitrophenol (4-NP) in aqueous media. Singlet oxygen was found to be involved in the phototransformation of 4-NP. Gas chromatographic separation gave hydroquinone and benzoquinone as the phototransformation products. Langmuir–Hinshelwood (L–H) model was employed to evaluate the adsorption and desorption equilibria of the reactants and the products. 2,3,9,10,16,17,23,24-octakis(dodecylthiophthalocyaninato) palladium(II) and 1,4,8,11,15,18,22,25-octakis(dodecylthio phthalocyaninato) palladium, containing the longest alkyl chain gave the best performances.
- Full Text:
- Date Issued: 2011
- Authors: Ogunbayo, Taofeek B , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247800 , vital:51619 , xlink:href="https://doi.org/10.1016/j.molcata.2011.01.016"
- Description: Adsorption of palladium phthalocyanines complexes on single walled carbon nanotubes was carried out. The resulting composites were employed as catalysts for heterogeneous photocatalytic oxidation of 4-nitrophenol (4-NP) in aqueous media. Singlet oxygen was found to be involved in the phototransformation of 4-NP. Gas chromatographic separation gave hydroquinone and benzoquinone as the phototransformation products. Langmuir–Hinshelwood (L–H) model was employed to evaluate the adsorption and desorption equilibria of the reactants and the products. 2,3,9,10,16,17,23,24-octakis(dodecylthiophthalocyaninato) palladium(II) and 1,4,8,11,15,18,22,25-octakis(dodecylthio phthalocyaninato) palladium, containing the longest alkyl chain gave the best performances.
- Full Text:
- Date Issued: 2011
Adoption, use and perception of Australian acacias around the world
- Kull, Christian A, Shackleton, Charlie M, Cunningham, Peter J, Ducatillon, Catherine, Dufour-Dror, Jean-Mark, Esler, Karen J, Friday, James B, Gouveia, António C, Griffin, A R, Marchante, Elizabete, Midgley, Steven J, Pauchard, Aníbal, Rangan, Haripriya, Richardson, David M, Rinaudo, Tony, Tassin, Jacques, Urgenson, Lauren S, van Maltitz, Graham P, Zenni, Rafael D, Zylstra, Matthew J
- Authors: Kull, Christian A , Shackleton, Charlie M , Cunningham, Peter J , Ducatillon, Catherine , Dufour-Dror, Jean-Mark , Esler, Karen J , Friday, James B , Gouveia, António C , Griffin, A R , Marchante, Elizabete , Midgley, Steven J , Pauchard, Aníbal , Rangan, Haripriya , Richardson, David M , Rinaudo, Tony , Tassin, Jacques , Urgenson, Lauren S , van Maltitz, Graham P , Zenni, Rafael D , Zylstra, Matthew J
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/182149 , vital:43804 , xlink:href="https://doi.org/10.1111/j.1472-4642.2011.00783.x"
- Description: To examine the different uses and perceptions of introduced Australian acacias (wattles; Acacia subgenus Phyllodineae) by rural households and communities. Eighteen landscape-scale case studies around the world, in Vietnam, India, Réunion, Madagascar, South Africa, Congo, Niger, Ethiopia, Israel, France, Portugal, Brazil, Chile, Dominican Republic and Hawai‘i. Qualitative comparison of case studies, based on questionnaire sent to network of acacia researchers. Information based on individual knowledge of local experts, published and unpublished sources. We propose a conceptual model to explain current uses and perceptions of introduced acacias. It highlights historically and geographically contingent processes, including economic development, environmental discourses, political context, and local or regional needs. Four main groupings of case studies were united by similar patterns: (1) poor communities benefiting from targeted agroforestry projects; (2) places where residents, generally poor, take advantage of a valuable resource already present in their landscape via plantation and/or invasion; (3) regions of small and mid-scale tree farmers participating in the forestry industry; and (4) a number of high-income communities dealing with the legacies of former or niche use of introduced acacia in a context of increased concern over biodiversity and ecosystem services. Economic conditions play a key role shaping acacia use. Poorer communities rely strongly on acacias (often in, or escaped from, formal plantations) for household needs and, sometimes, for income. Middle-income regions more typically host private farm investments in acacia woodlots for commercialization. Efforts at control of invasive acacias must take care to not adversely impact poor dependent communities.
- Full Text:
- Date Issued: 2011
- Authors: Kull, Christian A , Shackleton, Charlie M , Cunningham, Peter J , Ducatillon, Catherine , Dufour-Dror, Jean-Mark , Esler, Karen J , Friday, James B , Gouveia, António C , Griffin, A R , Marchante, Elizabete , Midgley, Steven J , Pauchard, Aníbal , Rangan, Haripriya , Richardson, David M , Rinaudo, Tony , Tassin, Jacques , Urgenson, Lauren S , van Maltitz, Graham P , Zenni, Rafael D , Zylstra, Matthew J
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/182149 , vital:43804 , xlink:href="https://doi.org/10.1111/j.1472-4642.2011.00783.x"
- Description: To examine the different uses and perceptions of introduced Australian acacias (wattles; Acacia subgenus Phyllodineae) by rural households and communities. Eighteen landscape-scale case studies around the world, in Vietnam, India, Réunion, Madagascar, South Africa, Congo, Niger, Ethiopia, Israel, France, Portugal, Brazil, Chile, Dominican Republic and Hawai‘i. Qualitative comparison of case studies, based on questionnaire sent to network of acacia researchers. Information based on individual knowledge of local experts, published and unpublished sources. We propose a conceptual model to explain current uses and perceptions of introduced acacias. It highlights historically and geographically contingent processes, including economic development, environmental discourses, political context, and local or regional needs. Four main groupings of case studies were united by similar patterns: (1) poor communities benefiting from targeted agroforestry projects; (2) places where residents, generally poor, take advantage of a valuable resource already present in their landscape via plantation and/or invasion; (3) regions of small and mid-scale tree farmers participating in the forestry industry; and (4) a number of high-income communities dealing with the legacies of former or niche use of introduced acacia in a context of increased concern over biodiversity and ecosystem services. Economic conditions play a key role shaping acacia use. Poorer communities rely strongly on acacias (often in, or escaped from, formal plantations) for household needs and, sometimes, for income. Middle-income regions more typically host private farm investments in acacia woodlots for commercialization. Efforts at control of invasive acacias must take care to not adversely impact poor dependent communities.
- Full Text:
- Date Issued: 2011
Study South Africa
- International Education Association of South Africa (IEASA), Jooste, Nico
- Authors: International Education Association of South Africa (IEASA) , Jooste, Nico
- Date: 2011
- Subjects: Education, Higher -- South Africa , Universities and colleges -- South Africa , Technical Institutes -- South Africa , Vocational guidance -- South Africa
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/64952 , vital:28639 , ISBN 9780620512244
- Description: [Extract from article by Ms Merle Hodges]: Over the past year there have been numerous conferences dealing with one general topic. How is it possible for higher education, globally, to produce the same quality in its graduates, research and community outreach when the financial resources entering into the system are radically declining? The conclusion is overwhelmingly despondent. ‘Universities have to do more with less, academics and academic research will increasingly be pressurised by lower salaries internally and career temptations from the corporate world – the impact of which is the greater commodification of universities, and the inevitable decline in academic freedom.’ This global negativity is predicated on inter–related factors. The first, the long tail of the economic recession, is continuing to bite all sectors and higher education is no exception. Secondly, higher education is a little like marketing – when the pressure is on government, sectors like higher education are de–prioritised. In light of this, the position of internationalisation in higher education might seem to fade into the background. Interestingly, the inverse is true. While the zeitgeist of higher education generally appears dismal, the prospects of internationalisation appear rosy in comparison. I believe this is true because of two overlapping issues. Firstly, students are not going to give up on university because of a lingering economic downturn. What they are doing, however, is deciding to travel and study at destinations that would have been perceived as implausible a few years ago. Venezuela, Chile, South Korea and South Africa are all drawing US students more than ever before. This is partly because, I sense, the quality of qualifications is achieving parity across the globe; and also, because students who are prepared to travel realise that cultural specificity – the ability to learn new and unique aspects of a different culture while gaining the same core ingredients of a degree – sets it apart from the degree gained locally. A one semester course in Russian anthropology might appear entirely redundant when applying for a job. However, the very interconnectedness of global business means not only that the course is never a waste of time, but that it might mean the difference between landing a contract and failing to do so. The international student has the benefit of developing in ways that traditional (home-grown) higher education may not yet fully understand. Secondly, development in South Africa at least, has an additional meaning. Our universities are not only focused on developing graduates for multicultural or global competitiveness. Over the past five or so years our universities have been focused on development of the country itself. As an emerging power, the impetus has been on creating universities that address the fundamental needs of the people. Poverty, HIV, sustainability and innovative solutions to global problems are the very sap of South African universities in the 21st Century. How to create a sustainable environment, how to preserve marine and wildlife, how to create jobs, reduce poverty, and maximise innovation – these are the concerns that are preoccupying the minds of the country’s best academics. , 11th Edition
- Full Text:
- Date Issued: 2011
- Authors: International Education Association of South Africa (IEASA) , Jooste, Nico
- Date: 2011
- Subjects: Education, Higher -- South Africa , Universities and colleges -- South Africa , Technical Institutes -- South Africa , Vocational guidance -- South Africa
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/64952 , vital:28639 , ISBN 9780620512244
- Description: [Extract from article by Ms Merle Hodges]: Over the past year there have been numerous conferences dealing with one general topic. How is it possible for higher education, globally, to produce the same quality in its graduates, research and community outreach when the financial resources entering into the system are radically declining? The conclusion is overwhelmingly despondent. ‘Universities have to do more with less, academics and academic research will increasingly be pressurised by lower salaries internally and career temptations from the corporate world – the impact of which is the greater commodification of universities, and the inevitable decline in academic freedom.’ This global negativity is predicated on inter–related factors. The first, the long tail of the economic recession, is continuing to bite all sectors and higher education is no exception. Secondly, higher education is a little like marketing – when the pressure is on government, sectors like higher education are de–prioritised. In light of this, the position of internationalisation in higher education might seem to fade into the background. Interestingly, the inverse is true. While the zeitgeist of higher education generally appears dismal, the prospects of internationalisation appear rosy in comparison. I believe this is true because of two overlapping issues. Firstly, students are not going to give up on university because of a lingering economic downturn. What they are doing, however, is deciding to travel and study at destinations that would have been perceived as implausible a few years ago. Venezuela, Chile, South Korea and South Africa are all drawing US students more than ever before. This is partly because, I sense, the quality of qualifications is achieving parity across the globe; and also, because students who are prepared to travel realise that cultural specificity – the ability to learn new and unique aspects of a different culture while gaining the same core ingredients of a degree – sets it apart from the degree gained locally. A one semester course in Russian anthropology might appear entirely redundant when applying for a job. However, the very interconnectedness of global business means not only that the course is never a waste of time, but that it might mean the difference between landing a contract and failing to do so. The international student has the benefit of developing in ways that traditional (home-grown) higher education may not yet fully understand. Secondly, development in South Africa at least, has an additional meaning. Our universities are not only focused on developing graduates for multicultural or global competitiveness. Over the past five or so years our universities have been focused on development of the country itself. As an emerging power, the impetus has been on creating universities that address the fundamental needs of the people. Poverty, HIV, sustainability and innovative solutions to global problems are the very sap of South African universities in the 21st Century. How to create a sustainable environment, how to preserve marine and wildlife, how to create jobs, reduce poverty, and maximise innovation – these are the concerns that are preoccupying the minds of the country’s best academics. , 11th Edition
- Full Text:
- Date Issued: 2011
The nature of geometry instruction and observed learning-outcomes opportunities in Nigerian and South African high schools:
- Atebe, Humphrey U, Schäfer, Marc
- Authors: Atebe, Humphrey U , Schäfer, Marc
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140919 , vital:37929 , DOI: 10.1080/10288457.2011.10740712
- Description: The purpose of this qualitative case study involving six secondary school teachers was to obtain insight into how geometry is taught in selected Nigerian and South African high schools. It also aimed, by making use of the van Hiele model of geometry instruction, to elucidate what possible learning opportunities observed instructional methods could offer learners in the subject. The sample comprised three mathematics teachers from Nigeria and three mathematics teachers from South Africa, all of whom were selected using purposive sampling techniques. Instructional activities in six geometry classrooms were recorded on videotape. The van Hiele learning phases provided the framework for data analysis. The findings of this study indicate that observed teaching methods in geometry classrooms in the participating schools offer learners scant opportunity to learn geometry.
- Full Text:
- Date Issued: 2013
- Authors: Atebe, Humphrey U , Schäfer, Marc
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140919 , vital:37929 , DOI: 10.1080/10288457.2011.10740712
- Description: The purpose of this qualitative case study involving six secondary school teachers was to obtain insight into how geometry is taught in selected Nigerian and South African high schools. It also aimed, by making use of the van Hiele model of geometry instruction, to elucidate what possible learning opportunities observed instructional methods could offer learners in the subject. The sample comprised three mathematics teachers from Nigeria and three mathematics teachers from South Africa, all of whom were selected using purposive sampling techniques. Instructional activities in six geometry classrooms were recorded on videotape. The van Hiele learning phases provided the framework for data analysis. The findings of this study indicate that observed teaching methods in geometry classrooms in the participating schools offer learners scant opportunity to learn geometry.
- Full Text:
- Date Issued: 2013
Journal of learner writing / Phemba Mfundi
- Nelson Mandela Institute for Education and Rural Development
- Authors: Nelson Mandela Institute for Education and Rural Development
- Date: 2011
- Subjects: Inkedama -- Ukufa , Protests -- Our roots , Protest -- Praise poems , Oomana -- Women , Umtshato -- Wedding -- Humanities , Ugawulayo -- HIV & AIDS , Indalo -- Nature , Ulawulo ngomelo -- Inkululeko--Democracy and freedom , Amaqhawe namaqhawekazi -- Heroes -- Heroines , Iincwadi namabali -- letters and stories , Phemba Mfundi Journal 2011
- Language: English , Xhosa
- Type: text
- Identifier: vital:12216 , http://hdl.handle.net/10353/d1013528 , Inkedama -- Ukufa , Protests -- Our roots , Protest -- Praise poems , Oomana -- Women , Umtshato -- Wedding -- Humanities , Ugawulayo -- HIV & AIDS , Indalo -- Nature , Ulawulo ngomelo -- Inkululeko--Democracy and freedom , Amaqhawe namaqhawekazi -- Heroes -- Heroines , Iincwadi namabali -- letters and stories
- Full Text:
- Date Issued: 2011
- Authors: Nelson Mandela Institute for Education and Rural Development
- Date: 2011
- Subjects: Inkedama -- Ukufa , Protests -- Our roots , Protest -- Praise poems , Oomana -- Women , Umtshato -- Wedding -- Humanities , Ugawulayo -- HIV & AIDS , Indalo -- Nature , Ulawulo ngomelo -- Inkululeko--Democracy and freedom , Amaqhawe namaqhawekazi -- Heroes -- Heroines , Iincwadi namabali -- letters and stories , Phemba Mfundi Journal 2011
- Language: English , Xhosa
- Type: text
- Identifier: vital:12216 , http://hdl.handle.net/10353/d1013528 , Inkedama -- Ukufa , Protests -- Our roots , Protest -- Praise poems , Oomana -- Women , Umtshato -- Wedding -- Humanities , Ugawulayo -- HIV & AIDS , Indalo -- Nature , Ulawulo ngomelo -- Inkululeko--Democracy and freedom , Amaqhawe namaqhawekazi -- Heroes -- Heroines , Iincwadi namabali -- letters and stories
- Full Text:
- Date Issued: 2011
Formation, surface characterization, and electrocatalytic application of self-assembled monolayer films of tetra-substituted manganese, iron, and cobalt benzylthio phthalocyanine complexes
- Akinbulu, Isaac Adebayo, Ozoemena, Kenneth Iyke, Nyokong, Tebello
- Authors: Akinbulu, Isaac Adebayo , Ozoemena, Kenneth Iyke , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247163 , vital:51552 , xlink:href="https://doi.org/10.1007/s10008-010-1243-1"
- Description: Molecular thin films of manganese (SAM-2), iron (SAM-3), and cobalt (SAM-4) phthalocyanine complexes, non-peripherally tetra-substituted with benzylmercapto, were formed on polycrystalline gold disc electrode by self-assembly technique. Surface characteristics of the films were interrogated by cyclic voltammetry. Significant passivation of voltammetry processes associated with bare gold surface (gold oxidation and underpotential deposition of copper) confirmed formation of the films. Electrocatalytic property of the films was evidenced from better voltammetry responses (less positive oxidation potential and better current signal) of the insecticide, carbofuran, on these films, relative to that on bare gold electrode. In terms of less positive oxidation potential, the FePc derivative (3) gave the best response, while the best current signal was observed on SAM-2-modified gold electrode. The average heterogeneous rate constant, k, for the oxidation of carbofuran was 3.6 × 10−2 cm s−1 on the SAM film with the best current signal (SAM-2).
- Full Text:
- Date Issued: 2011
- Authors: Akinbulu, Isaac Adebayo , Ozoemena, Kenneth Iyke , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247163 , vital:51552 , xlink:href="https://doi.org/10.1007/s10008-010-1243-1"
- Description: Molecular thin films of manganese (SAM-2), iron (SAM-3), and cobalt (SAM-4) phthalocyanine complexes, non-peripherally tetra-substituted with benzylmercapto, were formed on polycrystalline gold disc electrode by self-assembly technique. Surface characteristics of the films were interrogated by cyclic voltammetry. Significant passivation of voltammetry processes associated with bare gold surface (gold oxidation and underpotential deposition of copper) confirmed formation of the films. Electrocatalytic property of the films was evidenced from better voltammetry responses (less positive oxidation potential and better current signal) of the insecticide, carbofuran, on these films, relative to that on bare gold electrode. In terms of less positive oxidation potential, the FePc derivative (3) gave the best response, while the best current signal was observed on SAM-2-modified gold electrode. The average heterogeneous rate constant, k, for the oxidation of carbofuran was 3.6 × 10−2 cm s−1 on the SAM film with the best current signal (SAM-2).
- Full Text:
- Date Issued: 2011
The impact of HIV/AIDS on the delivery of maternal health care services of selected primary health care clinics of Peddie in the Eastern Cape Province
- Mangi, Nozuko Glenrose https://orcid.org/0000-0001-9158-8820
- Authors: Mangi, Nozuko Glenrose https://orcid.org/0000-0001-9158-8820
- Date: 2011
- Subjects: Maternal health services , Primary health care , HIV infections -- Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24576 , vital:63209
- Description: The aim of this descriptive study was to explore the impact of HIV/AIDS on the maternal health programme at selected Primary Health Care (PHC) clinics in the Peddie sub-district, in the Eastern Cape, South Africa. This study showed that the HIV/AIDS epidemic has had major influences on the rendering of maternal health services in this sub-district. An understanding of the impact of HIV/AIDS on the delivery of the maternal health programme in the Peddie Primary Health Clinics will potentially help the District Health Service office, as well as the clinic managers and professional nurses to formulate strategies to strengthen the maternal health programme. This data will also be helpful when developing plans to cope with the heavy work-load of the clinics offering maternal health services, and to address the attitudes and concerns of the professional nurses working in the PHC clinics in this area. Thirty professional nurses working at 10 clinics responded to the questionnaires which elicited questions pertaining to the impact of HIV/AIDS on the rendering of their services. As part of the data gathering procedures, standardised notice boards at the PHC clinics were used to document the services rendered. The numbers of ANC clients attended to each of the clinics per week were collected in routine attendance tick registers used in the clinics for recording and monitoring statistics in the maternal health programme. The data was analysed to examine the possible impact of HIV/AIDS on maternal health services rendered by registered nurses/midwives working in the PHC clinics. The registered nurses who responded to the questionnaires (Annexure H) made several suggestions. These included the following: (i) encouraged more training (11 nurses), (ii) addition of more staff members, (iii) to have specialized staff for management of maternal HIV. Because of the study limitations such as the sample size of 10 clinics with a total of 30 nurses who were studied, the study may not be generalised to the whole of the Eastern Cape Province. The study however did provide baseline information on the impact of HIV/AIDS on the maternal health programme. The study findings were that HIV/AIDS has had an impact on the delivery of the maternal health programme due to the extra services brought about by the response to the HIV/AIDS pandemic. This study will contribute to a better understanding of the impact of HIV/AIDS on the maternal health programme at the PHC level in Peddie. The research provided insight into issues that are crucial to the delivery of maternal health programmes in rural areas. , Thesis (MCur) -- Faculty of Science and Agriculture, 2011
- Full Text:
- Date Issued: 2011
- Authors: Mangi, Nozuko Glenrose https://orcid.org/0000-0001-9158-8820
- Date: 2011
- Subjects: Maternal health services , Primary health care , HIV infections -- Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24576 , vital:63209
- Description: The aim of this descriptive study was to explore the impact of HIV/AIDS on the maternal health programme at selected Primary Health Care (PHC) clinics in the Peddie sub-district, in the Eastern Cape, South Africa. This study showed that the HIV/AIDS epidemic has had major influences on the rendering of maternal health services in this sub-district. An understanding of the impact of HIV/AIDS on the delivery of the maternal health programme in the Peddie Primary Health Clinics will potentially help the District Health Service office, as well as the clinic managers and professional nurses to formulate strategies to strengthen the maternal health programme. This data will also be helpful when developing plans to cope with the heavy work-load of the clinics offering maternal health services, and to address the attitudes and concerns of the professional nurses working in the PHC clinics in this area. Thirty professional nurses working at 10 clinics responded to the questionnaires which elicited questions pertaining to the impact of HIV/AIDS on the rendering of their services. As part of the data gathering procedures, standardised notice boards at the PHC clinics were used to document the services rendered. The numbers of ANC clients attended to each of the clinics per week were collected in routine attendance tick registers used in the clinics for recording and monitoring statistics in the maternal health programme. The data was analysed to examine the possible impact of HIV/AIDS on maternal health services rendered by registered nurses/midwives working in the PHC clinics. The registered nurses who responded to the questionnaires (Annexure H) made several suggestions. These included the following: (i) encouraged more training (11 nurses), (ii) addition of more staff members, (iii) to have specialized staff for management of maternal HIV. Because of the study limitations such as the sample size of 10 clinics with a total of 30 nurses who were studied, the study may not be generalised to the whole of the Eastern Cape Province. The study however did provide baseline information on the impact of HIV/AIDS on the maternal health programme. The study findings were that HIV/AIDS has had an impact on the delivery of the maternal health programme due to the extra services brought about by the response to the HIV/AIDS pandemic. This study will contribute to a better understanding of the impact of HIV/AIDS on the maternal health programme at the PHC level in Peddie. The research provided insight into issues that are crucial to the delivery of maternal health programmes in rural areas. , Thesis (MCur) -- Faculty of Science and Agriculture, 2011
- Full Text:
- Date Issued: 2011
Electrooxidation of Chlorophenols Catalyzed by Nickel Octadecylphthalocyanine Adsorbed on Single‐Walled Carbon Nanotubes
- Khene, Samson, Nyokong, Tebello
- Authors: Khene, Samson , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247198 , vital:51555 , xlink:href="https://doi.org/10.1002/elan.201100155"
- Description: We described the synthesis of nickel octadecylphthalocyanine (NiPc(C10H21)8), followed by its adsorption on single-walled carbon nanotubes (SWCNT) to form SWCNT-NiPc(C10H21)8 conjugates. SWCNT-NiPc(C10H21)8 was used to modify a glassy carbon electrode (GCE) and for the electrooxidation of 4-chlorophenol and 2,4-dichlorophenol. The SWCNT and NiPc(C10H21)8 have a synergistic effect on each other in terms of improving electrocatalysis for the detection of chlorophenols. The stability of the electrode improved in the presence of NiPc(C10H21)8 or NiPc compared to the bare GCE. The presence of SWCNT improves the electrocatalytic behaviour of NiPc(C10H21)8 but not of unsubstituted NiPc. All modified electrodes showed improved stability towards the detection of 2,4-dichlorophenol. The best stability for 4-CP detection was observed in the presence of SWCNT for NiPc(C10H21)8.
- Full Text:
- Date Issued: 2011
- Authors: Khene, Samson , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247198 , vital:51555 , xlink:href="https://doi.org/10.1002/elan.201100155"
- Description: We described the synthesis of nickel octadecylphthalocyanine (NiPc(C10H21)8), followed by its adsorption on single-walled carbon nanotubes (SWCNT) to form SWCNT-NiPc(C10H21)8 conjugates. SWCNT-NiPc(C10H21)8 was used to modify a glassy carbon electrode (GCE) and for the electrooxidation of 4-chlorophenol and 2,4-dichlorophenol. The SWCNT and NiPc(C10H21)8 have a synergistic effect on each other in terms of improving electrocatalysis for the detection of chlorophenols. The stability of the electrode improved in the presence of NiPc(C10H21)8 or NiPc compared to the bare GCE. The presence of SWCNT improves the electrocatalytic behaviour of NiPc(C10H21)8 but not of unsubstituted NiPc. All modified electrodes showed improved stability towards the detection of 2,4-dichlorophenol. The best stability for 4-CP detection was observed in the presence of SWCNT for NiPc(C10H21)8.
- Full Text:
- Date Issued: 2011
Between a cushion and a risky conversation: ARTS LOUNGE reviewed
- Authors: Baasch, Rachel M
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147703 , vital:38662 , https://doi.org/10.1080/00043389.2011.11877155
- Description: On the fringe of the National Arts Festival, at a point of transition between Rhodes University campus and the commercial side of Grahamstown, the walls of a former home and former horse-stable, now a research house, reverberate with the strain of cross-disciplinary, site-specific collaboration. The ARTS LOUNGE made its first official appearance at the Grahamstown National Arts Festival (ViPPA Research Center, Rhodes University) from 30 June to 9 July 2011. The ten-day event was organised by the Visual and Performing Arts of Africa Research (ViPPA) team in collaboration with musicians, artists, writers, performers and members of the public.
- Full Text:
- Date Issued: 2017
- Authors: Baasch, Rachel M
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147703 , vital:38662 , https://doi.org/10.1080/00043389.2011.11877155
- Description: On the fringe of the National Arts Festival, at a point of transition between Rhodes University campus and the commercial side of Grahamstown, the walls of a former home and former horse-stable, now a research house, reverberate with the strain of cross-disciplinary, site-specific collaboration. The ARTS LOUNGE made its first official appearance at the Grahamstown National Arts Festival (ViPPA Research Center, Rhodes University) from 30 June to 9 July 2011. The ten-day event was organised by the Visual and Performing Arts of Africa Research (ViPPA) team in collaboration with musicians, artists, writers, performers and members of the public.
- Full Text:
- Date Issued: 2017
Biphenyl sorption to different soil clay minerals
- Tandlich, Roman, Baláž, Štefan
- Authors: Tandlich, Roman , Baláž, Štefan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76869 , vital:30632 , https://doi.org/10.5897/AJAR10.1012
- Description: Only limited information is available in the literature on the role of soil mineral surfaces in the sorption of hydrophobic organic pollutants. This knowledge gap is addressed through the assessment of biphenyl sorption to kaolinite, illite and bentonite; using the batch equilibration technique with incubations lasting 6 or 21 days at 28 ± 2°C in the dark [RT1]. Sorption of biphenyl onto kaolinite followed the Freundlich sorption isotherm, whereas linear sorption isotherms were observed on illite and bentonite [RT2]. The biphenyl sorption partition coefficient on kaolinite ranged from 0.1 to 9.1 cm3.g-1 after 6 days and no sorption was observed after 21 days. This could have been caused by a completely reversible sorption or a loss of binding capacity after 21 days [RT3]. The respective values of the biphenyl sorption partition coefficient on illite and bentonite ranged from 20.3 ± 0.3 to 120 ± 8 cm3.g-1.Sorption equilibrium on the internal clay surfaces was reached after 6 days, as indicated by the sorption data for illite and bentonite [RT4]. Access of biphenyl molecules to the internal clay surfaces is a function of the ionic strength of soil solution and the soil organic matter is the dominant site for biphenyl sorption after 6 to 21 days.
- Full Text:
- Date Issued: 2011
- Authors: Tandlich, Roman , Baláž, Štefan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/76869 , vital:30632 , https://doi.org/10.5897/AJAR10.1012
- Description: Only limited information is available in the literature on the role of soil mineral surfaces in the sorption of hydrophobic organic pollutants. This knowledge gap is addressed through the assessment of biphenyl sorption to kaolinite, illite and bentonite; using the batch equilibration technique with incubations lasting 6 or 21 days at 28 ± 2°C in the dark [RT1]. Sorption of biphenyl onto kaolinite followed the Freundlich sorption isotherm, whereas linear sorption isotherms were observed on illite and bentonite [RT2]. The biphenyl sorption partition coefficient on kaolinite ranged from 0.1 to 9.1 cm3.g-1 after 6 days and no sorption was observed after 21 days. This could have been caused by a completely reversible sorption or a loss of binding capacity after 21 days [RT3]. The respective values of the biphenyl sorption partition coefficient on illite and bentonite ranged from 20.3 ± 0.3 to 120 ± 8 cm3.g-1.Sorption equilibrium on the internal clay surfaces was reached after 6 days, as indicated by the sorption data for illite and bentonite [RT4]. Access of biphenyl molecules to the internal clay surfaces is a function of the ionic strength of soil solution and the soil organic matter is the dominant site for biphenyl sorption after 6 to 21 days.
- Full Text:
- Date Issued: 2011
Evaluation of the kinetics and mechanism of drug release from Econazole nitrate nanosponge loaded Carbapol Hydrogel
- Sharma, Renuka, Walker, Roderick B, Pathak, Kamla
- Authors: Sharma, Renuka , Walker, Roderick B , Pathak, Kamla
- Date: 2011
- Language: English
- Type: text , Article
- Identifier: vital:6437 , http://hdl.handle.net/10962/d1006614
- Description: The objective of this study was to investigate the mechanism of release of econazole nitrate (EN) nanosponges loaded hydrogel and to compare it with EN hydrogel so as to develop an extended release topical drug delivery system of EN. Nanosponges of EN were prepared using ethyl cellulose and PVA by emulsion solvent evaporation method. On the basis of pharmacotechnical evaluation nanosponges with least particle size of 230.1 nm and good rheological properties were formulated as hydrogel (F1 – F7). In vitro drug release data of EN nanosponges loaded hydrogels in phosphate buffer pH 6.8 and 7.4 when analysed by GraphPad Prism software version 4.0 San Diego, USA best fitted the Makoid-2 Banakar model (R value greater than 0.98). The Korsmeyer-Peppas release exponent (n) ranged between 0.331 – 0.418, which confirmed diffusion as the principle mechanism of drug release. The release mechanism was further confirmed by calculating the ratio of exponents A/B ratio derived from the Kopcha model.
- Full Text:
- Date Issued: 2011
- Authors: Sharma, Renuka , Walker, Roderick B , Pathak, Kamla
- Date: 2011
- Language: English
- Type: text , Article
- Identifier: vital:6437 , http://hdl.handle.net/10962/d1006614
- Description: The objective of this study was to investigate the mechanism of release of econazole nitrate (EN) nanosponges loaded hydrogel and to compare it with EN hydrogel so as to develop an extended release topical drug delivery system of EN. Nanosponges of EN were prepared using ethyl cellulose and PVA by emulsion solvent evaporation method. On the basis of pharmacotechnical evaluation nanosponges with least particle size of 230.1 nm and good rheological properties were formulated as hydrogel (F1 – F7). In vitro drug release data of EN nanosponges loaded hydrogels in phosphate buffer pH 6.8 and 7.4 when analysed by GraphPad Prism software version 4.0 San Diego, USA best fitted the Makoid-2 Banakar model (R value greater than 0.98). The Korsmeyer-Peppas release exponent (n) ranged between 0.331 – 0.418, which confirmed diffusion as the principle mechanism of drug release. The release mechanism was further confirmed by calculating the ratio of exponents A/B ratio derived from the Kopcha model.
- Full Text:
- Date Issued: 2011
Human DNAJ in cancer and stem cells:
- Sterrenberg, Jason N, Edkins, Adrienne L, Blatch, Gregory L
- Authors: Sterrenberg, Jason N , Edkins, Adrienne L , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165118 , vital:41210 , DOI: 10.1016/j.canlet.2011.08.019
- Description: The heat shock protein 40 kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions that may be independent of either of these chaperones. The DNAJ proteins are differentially expressed in human tissues and demonstrate the capacity to function to both promote and suppress cancer development by acting as chaperones for tumour suppressors or oncoproteins. We review the current literature on the function and expression of DNAJ in cancer, stem cells and cancer stem cells. Combining data from gene expression, proteomics and studies in other systems, we propose that DNAJ will be key regulators of cancer, stem cell and possibly cancer stem cell function. The diversity of DNAJ and their assorted roles in a range of biological functions means that selected DNAJ, provided there is limited redundancy and that a specific link to malignancy can be established, may yet provide an attractive target for specific and selective drug design for the development of anti-cancer treatments.
- Full Text:
- Date Issued: 2011
- Authors: Sterrenberg, Jason N , Edkins, Adrienne L , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165118 , vital:41210 , DOI: 10.1016/j.canlet.2011.08.019
- Description: The heat shock protein 40 kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions that may be independent of either of these chaperones. The DNAJ proteins are differentially expressed in human tissues and demonstrate the capacity to function to both promote and suppress cancer development by acting as chaperones for tumour suppressors or oncoproteins. We review the current literature on the function and expression of DNAJ in cancer, stem cells and cancer stem cells. Combining data from gene expression, proteomics and studies in other systems, we propose that DNAJ will be key regulators of cancer, stem cell and possibly cancer stem cell function. The diversity of DNAJ and their assorted roles in a range of biological functions means that selected DNAJ, provided there is limited redundancy and that a specific link to malignancy can be established, may yet provide an attractive target for specific and selective drug design for the development of anti-cancer treatments.
- Full Text:
- Date Issued: 2011
The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3
- Mautsa, Nicodemus, Prinsloo, Earl, Tastan Bishop, Özlem, Blatch, Gregory L
- Authors: Mautsa, Nicodemus , Prinsloo, Earl , Tastan Bishop, Özlem , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148082 , vital:38708 , DOI: 10.1002/jmr.1111
- Description: The protein inhibitor of activated signal transducer and activator of transcription 3 (PIAS3) regulates the transcriptional activity of signal transducer and activator of transcription 3 (STAT3) which regulates transcription of genes involved in cell growth, proliferation and apoptosis. The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3–PIAS3 interaction.
- Full Text:
- Date Issued: 2011
- Authors: Mautsa, Nicodemus , Prinsloo, Earl , Tastan Bishop, Özlem , Blatch, Gregory L
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148082 , vital:38708 , DOI: 10.1002/jmr.1111
- Description: The protein inhibitor of activated signal transducer and activator of transcription 3 (PIAS3) regulates the transcriptional activity of signal transducer and activator of transcription 3 (STAT3) which regulates transcription of genes involved in cell growth, proliferation and apoptosis. The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3–PIAS3 interaction.
- Full Text:
- Date Issued: 2011