Synthesis and pharmacological evaluation of chlorin derivatives for photodynamic therapy of cholangiocarcinoma
- Gao, Ying-Hua, Li, Man-Yi, Saijad, Faiza, Wang, Jin-Hai, Meharban, Faiza, Gadoora, Malaz A, Yan, Yi-Jia, Nyokong, Tebello, Chen, Zhi-Long
- Authors: Gao, Ying-Hua , Li, Man-Yi , Saijad, Faiza , Wang, Jin-Hai , Meharban, Faiza , Gadoora, Malaz A , Yan, Yi-Jia , Nyokong, Tebello , Chen, Zhi-Long
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/190873 , vital:45036 , xlink:href="https://doi.org/10.1016/j.ejmech.2020.112049"
- Description: Photodynamic therapy (PDT) has been developed as a promising therapeutic method in cancer treatment. The discovery of effective photosensitizer, which is the key factor of PDT, is highly desired. This paper reports the synthesis of novel chlorin derivatives, 5,10,15,20-tetraphenyl-[2:3]-[(methoxycarbonyl, carboxy)methano] chlorin I and 5,10,15,20-tetraphenyl-[2:3]- {[methoxycarbonyl, (2-hydroxyethyl)amide]methano}chlorin II. Their structures were characterized with UV–vis, 1HNMR, 13CNMR and HRMS spectroscopies. Photophysical and photochemical experiments results showed that compound I and II had an absorption maximum around 650 nm, with molar extinction coefficients of 1 × 104 M−1 cm−1. They had strong fluorescence emission in 650–660 nm upon excitation with 419–422 nm light. ESR showed that singlet oxygen was produced upon irradiation of compounds with 650 nm light in the presence of molecular oxygen. The photo-bleaching test indicated that the structure of compounds was stable. These new compounds exhibit excellent anti-tumor effects and lower toxicity compared to m-THPC in vitro and in vivo. Compound I and II had high tumor selectivity, which could induced tumor cells shrinkage and necrosis under 650 nm laser irradiation. Flow cytometry revealed that the compounds might mediate PDT effect at late apoptotic phase. These results make these compound I and II promising candidates for future study in photo-diagnosis and photodynamic therapy of cholangiocarcinoma.
- Full Text:
- Authors: Gao, Ying-Hua , Li, Man-Yi , Saijad, Faiza , Wang, Jin-Hai , Meharban, Faiza , Gadoora, Malaz A , Yan, Yi-Jia , Nyokong, Tebello , Chen, Zhi-Long
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/190873 , vital:45036 , xlink:href="https://doi.org/10.1016/j.ejmech.2020.112049"
- Description: Photodynamic therapy (PDT) has been developed as a promising therapeutic method in cancer treatment. The discovery of effective photosensitizer, which is the key factor of PDT, is highly desired. This paper reports the synthesis of novel chlorin derivatives, 5,10,15,20-tetraphenyl-[2:3]-[(methoxycarbonyl, carboxy)methano] chlorin I and 5,10,15,20-tetraphenyl-[2:3]- {[methoxycarbonyl, (2-hydroxyethyl)amide]methano}chlorin II. Their structures were characterized with UV–vis, 1HNMR, 13CNMR and HRMS spectroscopies. Photophysical and photochemical experiments results showed that compound I and II had an absorption maximum around 650 nm, with molar extinction coefficients of 1 × 104 M−1 cm−1. They had strong fluorescence emission in 650–660 nm upon excitation with 419–422 nm light. ESR showed that singlet oxygen was produced upon irradiation of compounds with 650 nm light in the presence of molecular oxygen. The photo-bleaching test indicated that the structure of compounds was stable. These new compounds exhibit excellent anti-tumor effects and lower toxicity compared to m-THPC in vitro and in vivo. Compound I and II had high tumor selectivity, which could induced tumor cells shrinkage and necrosis under 650 nm laser irradiation. Flow cytometry revealed that the compounds might mediate PDT effect at late apoptotic phase. These results make these compound I and II promising candidates for future study in photo-diagnosis and photodynamic therapy of cholangiocarcinoma.
- Full Text:
Development of paper-based aptasensors for detection of Plasmodium falciparum lactate dehydrogenase in malaria
- Ogunmolasuyi, Adewoyin Martin
- Authors: Ogunmolasuyi, Adewoyin Martin
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164601 , vital:41147 , doi:10.21504/10962/164601
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Biotechnology Innovation Centre, 2020
- Full Text:
- Authors: Ogunmolasuyi, Adewoyin Martin
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164601 , vital:41147 , doi:10.21504/10962/164601
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Biotechnology Innovation Centre, 2020
- Full Text:
Investigating the relationship between Heat Shock Proteins and HIV Transactivator of Transcription
- Authors: Flax, Lili Marie
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/163307 , vital:41027
- Description: Thesis (MSc)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020.
- Full Text:
- Authors: Flax, Lili Marie
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/163307 , vital:41027
- Description: Thesis (MSc)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020.
- Full Text:
Detection and effects of selected pharmaceutical compounds from selected water bodies in the Eastern Cape Province, South Africa
- Authors: Setshedi, Koketso Josinah
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177074 , vital:42788
- Description: Theses embargoed. Release date March 2023. , Thesis (MSc) -- Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2021
- Full Text:
- Authors: Setshedi, Koketso Josinah
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177074 , vital:42788
- Description: Theses embargoed. Release date March 2023. , Thesis (MSc) -- Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2021
- Full Text:
Understanding the livelihoods of Zimbabwean informal traders in South Africa: the case of Makhanda
- Musiyandaka, Tariro Henrietta
- Authors: Musiyandaka, Tariro Henrietta
- Date: 2020
- Subjects: Informal sector (Economics) South Africa Makhanda , Foreign workers, Zimbabwean South Africa Makhanda Economic conditions , Foreign workers, Zimbabwean South Africa Makhanda Social conditions , Street vendors South Africa Makhanda
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/164535 , vital:41127
- Description: Increasingly, Zimbabweans are migrating from their country for both economic and political reasons, with South Africa being the primary destination. In seeking employment in South Africa, Zimbabweans face numerous initial problems, including the high unemployment rate in the country alongside restrictions on their employment in the formal economy. In this context, Zimbabweans often turn to work in the informal economy, including as informal traders. This thesis seeks to understand the lives and livelihoods of Zimbabwean informal traders in Makhanda in the Eastern Cape Province of South Africa. Drawing upon the Sustainable Livelihoods Approach, and in the light of existing literature on Zimbabweans more broadly in South Africa, the thesis examines the livelihoods of a purposeful sampled grouping of six informal traders from Zimbabwe in Makhanda. It discusses their reasons for leaving Zimbabwe, their journey from Zimbabwe to Makhanda, relationships amongst themselves and their ongoing relationships with family back home, as well as their hopes and plans for the future. It also examines more specifically their livelihood activities, the daily challenges they face in pursuing their livelihoods and concerns about their livelihood status in South Africa. Despite the many deep-rooted systemic obstacles confronting these Zimbabwean informal traders, the thesis concludes that they demonstrate significant micro-level ingenuity in pursuing their livelihoods in South Africa. , Thesis (MA) -- Faculty of Faculty of Humanities, Sociology, 2020
- Full Text:
- Authors: Musiyandaka, Tariro Henrietta
- Date: 2020
- Subjects: Informal sector (Economics) South Africa Makhanda , Foreign workers, Zimbabwean South Africa Makhanda Economic conditions , Foreign workers, Zimbabwean South Africa Makhanda Social conditions , Street vendors South Africa Makhanda
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/164535 , vital:41127
- Description: Increasingly, Zimbabweans are migrating from their country for both economic and political reasons, with South Africa being the primary destination. In seeking employment in South Africa, Zimbabweans face numerous initial problems, including the high unemployment rate in the country alongside restrictions on their employment in the formal economy. In this context, Zimbabweans often turn to work in the informal economy, including as informal traders. This thesis seeks to understand the lives and livelihoods of Zimbabwean informal traders in Makhanda in the Eastern Cape Province of South Africa. Drawing upon the Sustainable Livelihoods Approach, and in the light of existing literature on Zimbabweans more broadly in South Africa, the thesis examines the livelihoods of a purposeful sampled grouping of six informal traders from Zimbabwe in Makhanda. It discusses their reasons for leaving Zimbabwe, their journey from Zimbabwe to Makhanda, relationships amongst themselves and their ongoing relationships with family back home, as well as their hopes and plans for the future. It also examines more specifically their livelihood activities, the daily challenges they face in pursuing their livelihoods and concerns about their livelihood status in South Africa. Despite the many deep-rooted systemic obstacles confronting these Zimbabwean informal traders, the thesis concludes that they demonstrate significant micro-level ingenuity in pursuing their livelihoods in South Africa. , Thesis (MA) -- Faculty of Faculty of Humanities, Sociology, 2020
- Full Text:
Investigating cell culture models for improved understanding of adipose tissue and co-morbidities in vitro
- Authors: Stoffels, Mihlali
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/164674 , vital:41154
- Description: Thesis (MSc)--Rhodes University, Faculty of Science, Biotechnology Innovation Centre, 2020
- Full Text:
- Authors: Stoffels, Mihlali
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/164674 , vital:41154
- Description: Thesis (MSc)--Rhodes University, Faculty of Science, Biotechnology Innovation Centre, 2020
- Full Text:
Synthesis of novel Schiff base cobalt (II) and iron (iii) complexes as cathode catalysts for microbial fuel cell applications
- Sen, Pinar, Akagunduz, Dilan, Aghdam, Araz S, Cebeci, Fevzi C, Nyokong, Tebello, Catal, Tunc
- Authors: Sen, Pinar , Akagunduz, Dilan , Aghdam, Araz S , Cebeci, Fevzi C , Nyokong, Tebello , Catal, Tunc
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/190861 , vital:45035 , xlink:href="https://doi.org/10.1007/s10904-019-01286-x"
- Description: In this study, the synthesis and characterization of a new Schiff base and its cobalt(II) and iron(III) complexes were performed fully characterized by common spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR, UV–Vis and MS and elemental analysis. The cathodes prepared with only activated carbon, Co-Schiff base complex, and Fe-Schiff base complex mixed with activated carbon as the carrier were examined in single chamber air cathode microbial fuel cells (MFCs). The spectroscopic results confirm the structure of novel Schiff base and its complexes with cobalt (II) and Fe(III). MFC results showed that Fe-Schiff base complex generated higher voltage generation using glucose as the carbon source. Cyclic voltammetry results showed the conductivity and catalytic features of the cathodes developed in this study. Scanning electron microscopic results showed the distribution the complexes on the cathode surface. In conclusion, a novel Schiff base and its complexes with cobalt (II) and iron (III) can be employed into MFC technology to be used in green electricity production, and might help decreasing the operating costs of wastewater treatment plants.
- Full Text:
- Authors: Sen, Pinar , Akagunduz, Dilan , Aghdam, Araz S , Cebeci, Fevzi C , Nyokong, Tebello , Catal, Tunc
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/190861 , vital:45035 , xlink:href="https://doi.org/10.1007/s10904-019-01286-x"
- Description: In this study, the synthesis and characterization of a new Schiff base and its cobalt(II) and iron(III) complexes were performed fully characterized by common spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR, UV–Vis and MS and elemental analysis. The cathodes prepared with only activated carbon, Co-Schiff base complex, and Fe-Schiff base complex mixed with activated carbon as the carrier were examined in single chamber air cathode microbial fuel cells (MFCs). The spectroscopic results confirm the structure of novel Schiff base and its complexes with cobalt (II) and Fe(III). MFC results showed that Fe-Schiff base complex generated higher voltage generation using glucose as the carbon source. Cyclic voltammetry results showed the conductivity and catalytic features of the cathodes developed in this study. Scanning electron microscopic results showed the distribution the complexes on the cathode surface. In conclusion, a novel Schiff base and its complexes with cobalt (II) and iron (III) can be employed into MFC technology to be used in green electricity production, and might help decreasing the operating costs of wastewater treatment plants.
- Full Text:
Forays into contemporary South African theatre
- Authors: Krueger, Anton
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/229578 , vital:49689 , xlink:href="https://doi.org/10.1080/10137548.2021.1963112"
- Description: Trying to keep up with what is going on in South African theatre today is an endlessly renewing process. The word ‘foray’ has associations of brief incursions into foreign territory. It’s an almost hesitant word, a venture into unexplored terrain. This hesitation feels apt in the sense that (at the time of writing), any description of a pre-Covid theatre is bound to feel strange. The landscape has shifted, and nobody is quite sure how things will look in a year from now. Nevertheless, this is a rich compendium of relatively recent theatre, as seen from within the country and also from the vantage of a global perspective. Almost all of the essays are drawn from a 2017 conference held in Brussels at the Université Libre de Bruxelles, called: ‘New Stage Idioms: South African Drama, Theatre and Performance in the Twenty-first Century.’Although the tone remains scholarly, the inclusion of different kinds of writers – not only academics but activists, playwrights and journalists – prevents the work from becoming overly dry.
- Full Text:
- Authors: Krueger, Anton
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/229578 , vital:49689 , xlink:href="https://doi.org/10.1080/10137548.2021.1963112"
- Description: Trying to keep up with what is going on in South African theatre today is an endlessly renewing process. The word ‘foray’ has associations of brief incursions into foreign territory. It’s an almost hesitant word, a venture into unexplored terrain. This hesitation feels apt in the sense that (at the time of writing), any description of a pre-Covid theatre is bound to feel strange. The landscape has shifted, and nobody is quite sure how things will look in a year from now. Nevertheless, this is a rich compendium of relatively recent theatre, as seen from within the country and also from the vantage of a global perspective. Almost all of the essays are drawn from a 2017 conference held in Brussels at the Université Libre de Bruxelles, called: ‘New Stage Idioms: South African Drama, Theatre and Performance in the Twenty-first Century.’Although the tone remains scholarly, the inclusion of different kinds of writers – not only academics but activists, playwrights and journalists – prevents the work from becoming overly dry.
- Full Text:
Development of a protocol for extracting and quantifying the concentration of thiafentanil in blesbok (Damaliscus pygargus phillipsi) matrices 72-74 hours post administration
- Authors: Webber, Judith Tracy
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/164738 , vital:41159
- Description: Thesis (MSc)--Rhodes University, Faculty of Science, Chemistry, 2020
- Full Text:
- Authors: Webber, Judith Tracy
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/164738 , vital:41159
- Description: Thesis (MSc)--Rhodes University, Faculty of Science, Chemistry, 2020
- Full Text:
Multiplexed Mass Spectrometry: Single, On-Bead, Detection Analysis Using MALDI-TOF MS
- Authors: Twala, Busisiwe Victoria
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164693 , vital:41155 , doi:10.21504/10962/164693
- Description: Thesis (PhD)--Rhodes University, Biochemistry and Microbiology, 2020
- Full Text:
- Authors: Twala, Busisiwe Victoria
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164693 , vital:41155 , doi:10.21504/10962/164693
- Description: Thesis (PhD)--Rhodes University, Biochemistry and Microbiology, 2020
- Full Text:
A career in photophysicochemical and electrochemical properties of phthalocyanine: A Linstead Career Award paper
- Authors: Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186045 , vital:44458 , xlink:href="https://doi.org/10.1142/S1088424620300037"
- Description: This manuscript highlights the author’s contributions to phthalocyanine chemistry, especially the applications based on their electrochemistry and photophysicochemistry. In particular, the use of phthalocyanines as electrocatalysts and photocatalysts is presented. For photocatalysis, photodynamic antimicrobial chemotherapy and pollution control using green technologies are highlighted. For electrocatalysis the phthalocyanines are employed for the detection of pollutants and environmentally important molecules. Phthalocyanines are combined with nanomaterials for improved photocatalysis and electrocatalysis.
- Full Text:
- Authors: Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186045 , vital:44458 , xlink:href="https://doi.org/10.1142/S1088424620300037"
- Description: This manuscript highlights the author’s contributions to phthalocyanine chemistry, especially the applications based on their electrochemistry and photophysicochemistry. In particular, the use of phthalocyanines as electrocatalysts and photocatalysts is presented. For photocatalysis, photodynamic antimicrobial chemotherapy and pollution control using green technologies are highlighted. For electrocatalysis the phthalocyanines are employed for the detection of pollutants and environmentally important molecules. Phthalocyanines are combined with nanomaterials for improved photocatalysis and electrocatalysis.
- Full Text:
Nutrient impacts on grasses and legumes growing in communal pasture soil in relation to mycorrhizal activity
- Authors: Mkile, Zolani
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164512 , vital:41125 , doi:10.21504/10962/164512
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020
- Full Text:
- Authors: Mkile, Zolani
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164512 , vital:41125 , doi:10.21504/10962/164512
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020
- Full Text:
Synthesis of novel Schiff base cobalt (II) and iron (iii) complexes as cathode catalysts for microbial fuel cell applications
- Sen, Pinar, Akagunduz, Dilan, Aghdam, Araz Sheibani, Cebeci, Fevzi C, Nyokong, Tebello
- Authors: Sen, Pinar , Akagunduz, Dilan , Aghdam, Araz Sheibani , Cebeci, Fevzi C , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187015 , vital:44556 , xlink:href="https://doi.org/10.1007/s10904-019-01286-x"
- Description: In this study, the synthesis and characterization of a new Schiff base and its cobalt(II) and iron(III) complexes were performed fully characterized by common spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR, UV–Vis and MS and elemental analysis. The cathodes prepared with only activated carbon, Co-Schiff base complex, and Fe-Schiff base complex mixed with activated carbon as the carrier were examined in single chamber air cathode microbial fuel cells (MFCs). The spectroscopic results confirm the structure of novel Schiff base and its complexes with cobalt (II) and Fe(III). MFC results showed that Fe-Schiff base complex generated higher voltage generation using glucose as the carbon source. Cyclic voltammetry results showed the conductivity and catalytic features of the cathodes developed in this study. Scanning electron microscopic results showed the distribution the complexes on the cathode surface. In conclusion, a novel Schiff base and its complexes with cobalt (II) and iron (III) can be employed into MFC technology to be used in green electricity production, and might help decreasing the operating costs of wastewater treatment plants.
- Full Text:
- Authors: Sen, Pinar , Akagunduz, Dilan , Aghdam, Araz Sheibani , Cebeci, Fevzi C , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187015 , vital:44556 , xlink:href="https://doi.org/10.1007/s10904-019-01286-x"
- Description: In this study, the synthesis and characterization of a new Schiff base and its cobalt(II) and iron(III) complexes were performed fully characterized by common spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR, UV–Vis and MS and elemental analysis. The cathodes prepared with only activated carbon, Co-Schiff base complex, and Fe-Schiff base complex mixed with activated carbon as the carrier were examined in single chamber air cathode microbial fuel cells (MFCs). The spectroscopic results confirm the structure of novel Schiff base and its complexes with cobalt (II) and Fe(III). MFC results showed that Fe-Schiff base complex generated higher voltage generation using glucose as the carbon source. Cyclic voltammetry results showed the conductivity and catalytic features of the cathodes developed in this study. Scanning electron microscopic results showed the distribution the complexes on the cathode surface. In conclusion, a novel Schiff base and its complexes with cobalt (II) and iron (III) can be employed into MFC technology to be used in green electricity production, and might help decreasing the operating costs of wastewater treatment plants.
- Full Text:
Photodynamic antimicrobial chemotherapy of a dimethylamino-functionalized asymmetric zinc (II) phthalocyanine and its quaternized derivative against Staphylococcus aureus when supported on asymmetric polystyrene polymer membranes
- Mafukidze, Donovan M, Nyokong, Tebello
- Authors: Mafukidze, Donovan M , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186168 , vital:44470 , xlink:href="https://doi.org/10.1016/j.reactfunctpolym.2020.104634"
- Description: Membrane applications are hindered by fouling. Photoactive membranes (containing photosensitizers) show photodynamic antimicrobial chemotherapy (PACT) activity which reduces biological fouling. In this work we use phthalocyanines (Pcs) as photosensitizers. The Pcs used are: 2-(4-carboxyphenoxy)-9(10), 16(17), 23(24)-tris(dimethylamino) phthalocyaninato zinc(II) (1) and the quaternized 2-(4-carboxyphenoxy)-9(10), 16(17), 23(24)-tris(trimethylamino) phthalocyanine zinc(II) methyl sulfate (2). Complex 2 showed an enhanced singlet oxygen quantum yield (ΦΔ) of 0.76 compared to 0.53 for 1. Complex 2 showed enhanced PACT activity against Staphylococcus aureus giving a log reduction value of 9.4, while its precursor (complex 1) gave 0.08. The complexes were then conjugated to amine-functionalized polystyrene and embedded into polystyrene to form membranes resulting in ΦΔ values of 0.24 and 0.27 for complexes 1 and 2 respectively in water. The latter membrane showed better PACT activity.
- Full Text:
- Authors: Mafukidze, Donovan M , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186168 , vital:44470 , xlink:href="https://doi.org/10.1016/j.reactfunctpolym.2020.104634"
- Description: Membrane applications are hindered by fouling. Photoactive membranes (containing photosensitizers) show photodynamic antimicrobial chemotherapy (PACT) activity which reduces biological fouling. In this work we use phthalocyanines (Pcs) as photosensitizers. The Pcs used are: 2-(4-carboxyphenoxy)-9(10), 16(17), 23(24)-tris(dimethylamino) phthalocyaninato zinc(II) (1) and the quaternized 2-(4-carboxyphenoxy)-9(10), 16(17), 23(24)-tris(trimethylamino) phthalocyanine zinc(II) methyl sulfate (2). Complex 2 showed an enhanced singlet oxygen quantum yield (ΦΔ) of 0.76 compared to 0.53 for 1. Complex 2 showed enhanced PACT activity against Staphylococcus aureus giving a log reduction value of 9.4, while its precursor (complex 1) gave 0.08. The complexes were then conjugated to amine-functionalized polystyrene and embedded into polystyrene to form membranes resulting in ΦΔ values of 0.24 and 0.27 for complexes 1 and 2 respectively in water. The latter membrane showed better PACT activity.
- Full Text:
Application of In Vitro Release Testing (IVRT) and a dermatopharmacokinetic approach (tape stripping) for the assessment of Metronidazole topical formulations
- Rath, Seeprarani Prabirkumar
- Authors: Rath, Seeprarani Prabirkumar
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164617 , vital:41148 , doi:10.21504/10962/164617
- Description: Thesis (PhD)--Rhodes University, Faculty of Pharmacy, Pharmaceutics, 2020
- Full Text:
- Authors: Rath, Seeprarani Prabirkumar
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164617 , vital:41148 , doi:10.21504/10962/164617
- Description: Thesis (PhD)--Rhodes University, Faculty of Pharmacy, Pharmaceutics, 2020
- Full Text:
Investigation of electrocatalytic behaviour of low symmetry cobalt phthalocyanines when clicked to azide grafted carbon electrodes
- Mpeta, Lakethe S, Sen, Pinar, Nyokong, Tebello
- Authors: Mpeta, Lakethe S , Sen, Pinar , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186304 , vital:44483 , xlink:href="https://doi.org/10.1016/j.jelechem.2020.113896"
- Description: This work describes the electrochemical properties of low symmetry cobalt phthalocyanines namely, tris-[(4-tert-butylphenoxy)-4-(pent-4-yn-1-yloxy) phthalocyaniato] cobalt (II) (3) and tris-[(4-tert-butylphenoxy)-4-(4-ethybylbenzyl-oxy) phthalocyaniato] cobalt (II) (5). The complexes were characterized by a number of techniques including UV–Vis, mass, and infrared spectra, as well as elemental analysis. The glassy carbon electrodes were first azide functionalized then clicked to low symmetry phthalocyanines. The click reaction was confirmed using X-ray photoelectron spectra. The constructed electrodes showed excellent electrocatalytic activity towards hydrazine oxidation. Oxidation peaks with low potentials of 0.21 V and 0.26 V, for complexes 3 and 5, respectively were obtained. Complex-5 gave a better detection limit of 0.94 μM and electrocatalytic rate constant of 5.6 × 106 M−1 s−1.
- Full Text:
- Authors: Mpeta, Lakethe S , Sen, Pinar , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186304 , vital:44483 , xlink:href="https://doi.org/10.1016/j.jelechem.2020.113896"
- Description: This work describes the electrochemical properties of low symmetry cobalt phthalocyanines namely, tris-[(4-tert-butylphenoxy)-4-(pent-4-yn-1-yloxy) phthalocyaniato] cobalt (II) (3) and tris-[(4-tert-butylphenoxy)-4-(4-ethybylbenzyl-oxy) phthalocyaniato] cobalt (II) (5). The complexes were characterized by a number of techniques including UV–Vis, mass, and infrared spectra, as well as elemental analysis. The glassy carbon electrodes were first azide functionalized then clicked to low symmetry phthalocyanines. The click reaction was confirmed using X-ray photoelectron spectra. The constructed electrodes showed excellent electrocatalytic activity towards hydrazine oxidation. Oxidation peaks with low potentials of 0.21 V and 0.26 V, for complexes 3 and 5, respectively were obtained. Complex-5 gave a better detection limit of 0.94 μM and electrocatalytic rate constant of 5.6 × 106 M−1 s−1.
- Full Text:
Assessment of the microbial quality of various domestic rainwater harvesting systems and the suitability of a nano based treatment method
- Authors: Malema, Mokaba Shirley
- Date: 2020
- Language: English
- Type: thesis , text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/110218 , vital:33249 , https://dx.doi.org/10.21504/10962/110218
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Chemistry, 2020.
- Full Text: false
- Authors: Malema, Mokaba Shirley
- Date: 2020
- Language: English
- Type: thesis , text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/110218 , vital:33249 , https://dx.doi.org/10.21504/10962/110218
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Chemistry, 2020.
- Full Text: false
Epistemic Cartography: Evaluating Net-Map as a Frontline Tool for Navigating Informal Knowledge Networks
- Meterlerkamp, Luke, Schiffer, Eva
- Authors: Meterlerkamp, Luke , Schiffer, Eva
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/388009 , vital:68298 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/188690"
- Description: Sustainability transitions are dependent on the development and diffusion of transformative skills and competencies. However, the prevailing notion that learning for sustainability transitions will be led by universities, technical colleges and other similar institutions is practically not feasible in much of the global south. Net-Map is a social network analysis tool that uses interviews and mapping to help people understand, visualise, discuss, and improve situations in which many different actors influence outcomes (Schiffer and Hauck, 2010). In response to the pressing need for new approaches to the development and diffusion of sustainability skills, this paper evaluates Net-Map’s suitability as a methodological tool for educators, knowledge brokers and students seeking to enhance the navigability of the often complex and uncharted occupational pathways they encounter. To do this, the research applied Net-Map to an emerging sustainability niche within the food system in order to map the learning pathways of successful sustainability pioneers. We found that Net-Map was helpful in identifying diffuse informal knowledge networks and teaching resources. Being free, quick to learn and easy to use, Net-Map is a potentially low-cost method for circumventing traditionally costly approaches to curriculum development and accreditation – assisting community-based actors to make sense of the informal knowledge and competency networks that support emerging career fields. In emerging career fields such as organic farming, where pioneer knowledge is fragmented, poorly documented and often disregarded by mainstream-science, Net-Map could be useful in the preparatory phase of curriculum planning and design, providing training designers, course conveners and facilitators with contextually informed insights.
- Full Text:
- Authors: Meterlerkamp, Luke , Schiffer, Eva
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/388009 , vital:68298 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/188690"
- Description: Sustainability transitions are dependent on the development and diffusion of transformative skills and competencies. However, the prevailing notion that learning for sustainability transitions will be led by universities, technical colleges and other similar institutions is practically not feasible in much of the global south. Net-Map is a social network analysis tool that uses interviews and mapping to help people understand, visualise, discuss, and improve situations in which many different actors influence outcomes (Schiffer and Hauck, 2010). In response to the pressing need for new approaches to the development and diffusion of sustainability skills, this paper evaluates Net-Map’s suitability as a methodological tool for educators, knowledge brokers and students seeking to enhance the navigability of the often complex and uncharted occupational pathways they encounter. To do this, the research applied Net-Map to an emerging sustainability niche within the food system in order to map the learning pathways of successful sustainability pioneers. We found that Net-Map was helpful in identifying diffuse informal knowledge networks and teaching resources. Being free, quick to learn and easy to use, Net-Map is a potentially low-cost method for circumventing traditionally costly approaches to curriculum development and accreditation – assisting community-based actors to make sense of the informal knowledge and competency networks that support emerging career fields. In emerging career fields such as organic farming, where pioneer knowledge is fragmented, poorly documented and often disregarded by mainstream-science, Net-Map could be useful in the preparatory phase of curriculum planning and design, providing training designers, course conveners and facilitators with contextually informed insights.
- Full Text:
Formulation, development and assessment of devil’s claw loaded phyto-elastosomes in thermo-responsive hydrogels
- Authors: Ntemi, Pascal Vitalis
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164568 , vital:41139 , doi:10.21504/10962/164568
- Description: Thesis (PhD)--Rhodes University, Faculty of Pharmacy, Pharmaceutics, 2020
- Full Text:
- Authors: Ntemi, Pascal Vitalis
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/164568 , vital:41139 , doi:10.21504/10962/164568
- Description: Thesis (PhD)--Rhodes University, Faculty of Pharmacy, Pharmaceutics, 2020
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The role of the Hop co-chaperone in the formation of Hsp90 complexes: chaperone link to glycolysis
- Authors: Maharaj, Shantal
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/163593 , vital:41051 , doi:10.21504/10962/163593
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020
- Full Text:
- Authors: Maharaj, Shantal
- Date: 2020
- Subjects: Uncatalogued
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/163593 , vital:41051 , doi:10.21504/10962/163593
- Description: Thesis (PhD)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020
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