Review and development of environmental interpretation resources to foster environmental learning in two Kenyan schools
- Authors: Atiti, Abel Barasa
- Date: 2003
- Subjects: Environmental education -- Kenya Environmental education -- Kenya -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1743 , http://hdl.handle.net/10962/d1003627
- Description: This participatory action research study involved a group of teachers in transforming school grounds into interpretation resources. Approached from a critical perspective, it challenged the conventional top-down approaches to interpretation resources and materials development. Through a teacher-centred approach, a school-based ‘botanic garden’ and ‘arboretum’ were developed at Samaj and Kenya High respectively. Teachers were further actively engaged in developing a variety of interpretive materials that might engage learners in socially critical environmental education processes at the transformed sites. A process in which educators from five non-formal education organisations shared their skills and knowledge on environmental interpretation with teachers preceded the development of interpretation resources and materials. Drawing on Latour (1999), I have applied the notion of mobilising interpretive capital when describing this process. Interpretive capital within the non-formal education sector was mobilised and made available through social interactions between teachers and non-formal educators. This occurred during workshops, organisational visits and critical reviews of a sample of interpretive materials. I provide insights into how the interpretive capital was mobilised and later drawn on by teachers during the development processes in their schools. This study argues that mobilising interpretive capital with teachers through partnerships can enhance the transformation of school grounds to foster environmental learning. It shows how attempts to find solutions with teachers were made in response to pedagogical and curriculum tensions that arise around the implementation of environmental education processes in their schools. To provide orientation in environmental education processes in schools, analyses of socially critical environmental education processes and a review of theoretical perspectives on interpretation as an environmental education process are presented. I have viewed interpretation and environmental education as reciprocally necessary aspects for enabling the development of critical environmental literacy and action competence. To explain this view, the notion of environmental interpretation and education processes has been applied and presented in this study. Finally, practical outcomes of the study on transformation of school grounds, improved education practice, enhanced professional competencies amongst teachers, new interpretive materials in schools and the establishment of partnerships are examined.
- Full Text:
- Date Issued: 2003
- Authors: Atiti, Abel Barasa
- Date: 2003
- Subjects: Environmental education -- Kenya Environmental education -- Kenya -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1743 , http://hdl.handle.net/10962/d1003627
- Description: This participatory action research study involved a group of teachers in transforming school grounds into interpretation resources. Approached from a critical perspective, it challenged the conventional top-down approaches to interpretation resources and materials development. Through a teacher-centred approach, a school-based ‘botanic garden’ and ‘arboretum’ were developed at Samaj and Kenya High respectively. Teachers were further actively engaged in developing a variety of interpretive materials that might engage learners in socially critical environmental education processes at the transformed sites. A process in which educators from five non-formal education organisations shared their skills and knowledge on environmental interpretation with teachers preceded the development of interpretation resources and materials. Drawing on Latour (1999), I have applied the notion of mobilising interpretive capital when describing this process. Interpretive capital within the non-formal education sector was mobilised and made available through social interactions between teachers and non-formal educators. This occurred during workshops, organisational visits and critical reviews of a sample of interpretive materials. I provide insights into how the interpretive capital was mobilised and later drawn on by teachers during the development processes in their schools. This study argues that mobilising interpretive capital with teachers through partnerships can enhance the transformation of school grounds to foster environmental learning. It shows how attempts to find solutions with teachers were made in response to pedagogical and curriculum tensions that arise around the implementation of environmental education processes in their schools. To provide orientation in environmental education processes in schools, analyses of socially critical environmental education processes and a review of theoretical perspectives on interpretation as an environmental education process are presented. I have viewed interpretation and environmental education as reciprocally necessary aspects for enabling the development of critical environmental literacy and action competence. To explain this view, the notion of environmental interpretation and education processes has been applied and presented in this study. Finally, practical outcomes of the study on transformation of school grounds, improved education practice, enhanced professional competencies amongst teachers, new interpretive materials in schools and the establishment of partnerships are examined.
- Full Text:
- Date Issued: 2003
Investigations into the ecology of a population of Citrus Red Scale (Aonidiella aurantii Mask.) in the Swaziland lowlands
- Authors: Atkinson, P R
- Date: 1982
- Subjects: Citrus -- Diseases and pests -- Africa, Southern
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5619 , http://hdl.handle.net/10962/d1003733
- Description: In the Swaziland lowlands, biological control of the citrus pest red scale, Aonidiella aurantii (Mask), has been consistently unsuccessful although it is successful in middle altitude regions. However, recent cases of resistance to organophosphate insecticides elsewhere in southern Africa, make it important to reconsider biological control of red scale in the lowlands. Should similar resistance be evolved in this region, the pest could be controlled only by natural means together with oils. This account attempts to answer questions about the natural control of a red scale population in the lowlands, by examining data collected between 1972 and 1975. The population was continuously breeding with overlapped generations. It consisted of three sections, on leaves, twigs and fruit, having different rates of reproduction, development and mortality. These sections are considered separately but that on leaves, being relatively unimportant, is largely ignored. The generation mortality is estimated in the sections on twigs and fruit and related to climatic and biotic indices. The causes of seasonal and between-years variation in the sections on twigs and fruit are elucidated. The effectiveness of each kind of natural enemy is examined and the factors affecting natural enemy numbers are investigated. The question of population regulation is discussed. Differences in mean infestation levels in middle altitude and lowland regions are explained in terms of different rates of reproduction and mortality.
- Full Text:
- Date Issued: 1982
- Authors: Atkinson, P R
- Date: 1982
- Subjects: Citrus -- Diseases and pests -- Africa, Southern
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5619 , http://hdl.handle.net/10962/d1003733
- Description: In the Swaziland lowlands, biological control of the citrus pest red scale, Aonidiella aurantii (Mask), has been consistently unsuccessful although it is successful in middle altitude regions. However, recent cases of resistance to organophosphate insecticides elsewhere in southern Africa, make it important to reconsider biological control of red scale in the lowlands. Should similar resistance be evolved in this region, the pest could be controlled only by natural means together with oils. This account attempts to answer questions about the natural control of a red scale population in the lowlands, by examining data collected between 1972 and 1975. The population was continuously breeding with overlapped generations. It consisted of three sections, on leaves, twigs and fruit, having different rates of reproduction, development and mortality. These sections are considered separately but that on leaves, being relatively unimportant, is largely ignored. The generation mortality is estimated in the sections on twigs and fruit and related to climatic and biotic indices. The causes of seasonal and between-years variation in the sections on twigs and fruit are elucidated. The effectiveness of each kind of natural enemy is examined and the factors affecting natural enemy numbers are investigated. The question of population regulation is discussed. Differences in mean infestation levels in middle altitude and lowland regions are explained in terms of different rates of reproduction and mortality.
- Full Text:
- Date Issued: 1982
A phenomenological exploration of adoptive parents' motivation for and experience of transracial adoption in South Africa
- Authors: Attwell, Terry-Anne
- Date: 2004
- Subjects: Interracial adoption -- South Africa , Race awareness in children -- South Africa , Prejudices in children -- South Africa , Adoption -- Law and legislation -- South Africa , Children's rights -- South Africa , South Africa -- Race relations
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2927 , http://hdl.handle.net/10962/d1002436 , Interracial adoption -- South Africa , Race awareness in children -- South Africa , Prejudices in children -- South Africa , Adoption -- Law and legislation -- South Africa , Children's rights -- South Africa , South Africa -- Race relations
- Description: Prior to the democratic elections of 1994, South Africa was daunted by legislation flooded with racial segregation. Adoption across racial lines is, because of South Africa’s racially segregated past, a relatively recent phenomenon in this country. The number of legal adoptions has increased dramatically, especially after its legalization in 1991. Parents may adopt across racial lines for an array of different reasons, from not being able to conceive a baby, to wanting to give a child the best opportunity in life. This study explored the experiences of white parents who have adopted black children, paying particular attention to how they deal with issues of “racial” identity. In-depth interviews were used to generate qualitative data pertaining to the parental perceptions of their motivation for, and experiences of adopting a child transracially in South Africa. The study aimed to explore their motivation for adopting and experiences, as well as issues relating to “racial” identity. Recommendations have been made to assist parents who are interested in adopting transracially. The report presents findings relating to the unique characteristics of the participants who have adopted transracially. These include adopters’ motivation and thought processes before taking the relevant steps to adopt transracially; the support that they have received from others in their decision to adopt transracially; communication patterns; their relevant concerns regarding the future of their adopted child; and issues pertaining to race, culture, heritage, prejudices and stereotypes. The findings suggest that parents were pragmatic, without regrets, in their views about adopting across racial lines. The parents’ motivations for adopting across racial lines were very similar to various perspectives, but were all due to the fact that they were unable to have biological children. Parents were aware of the child’s identity and cultural issues, which may be more perceptible in the future. Their perceptions, views and opinions, and the future concerns of their children were not unrealistic. Due to the children’s young age a follow-up study of these children should be considered.
- Full Text:
- Date Issued: 2004
- Authors: Attwell, Terry-Anne
- Date: 2004
- Subjects: Interracial adoption -- South Africa , Race awareness in children -- South Africa , Prejudices in children -- South Africa , Adoption -- Law and legislation -- South Africa , Children's rights -- South Africa , South Africa -- Race relations
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2927 , http://hdl.handle.net/10962/d1002436 , Interracial adoption -- South Africa , Race awareness in children -- South Africa , Prejudices in children -- South Africa , Adoption -- Law and legislation -- South Africa , Children's rights -- South Africa , South Africa -- Race relations
- Description: Prior to the democratic elections of 1994, South Africa was daunted by legislation flooded with racial segregation. Adoption across racial lines is, because of South Africa’s racially segregated past, a relatively recent phenomenon in this country. The number of legal adoptions has increased dramatically, especially after its legalization in 1991. Parents may adopt across racial lines for an array of different reasons, from not being able to conceive a baby, to wanting to give a child the best opportunity in life. This study explored the experiences of white parents who have adopted black children, paying particular attention to how they deal with issues of “racial” identity. In-depth interviews were used to generate qualitative data pertaining to the parental perceptions of their motivation for, and experiences of adopting a child transracially in South Africa. The study aimed to explore their motivation for adopting and experiences, as well as issues relating to “racial” identity. Recommendations have been made to assist parents who are interested in adopting transracially. The report presents findings relating to the unique characteristics of the participants who have adopted transracially. These include adopters’ motivation and thought processes before taking the relevant steps to adopt transracially; the support that they have received from others in their decision to adopt transracially; communication patterns; their relevant concerns regarding the future of their adopted child; and issues pertaining to race, culture, heritage, prejudices and stereotypes. The findings suggest that parents were pragmatic, without regrets, in their views about adopting across racial lines. The parents’ motivations for adopting across racial lines were very similar to various perspectives, but were all due to the fact that they were unable to have biological children. Parents were aware of the child’s identity and cultural issues, which may be more perceptible in the future. Their perceptions, views and opinions, and the future concerns of their children were not unrealistic. Due to the children’s young age a follow-up study of these children should be considered.
- Full Text:
- Date Issued: 2004
"Why I like history ...": Ciskeian secondary school pupils' attitudes towards history
- Atuahene-Sarpong, Boateng Kofi
- Authors: Atuahene-Sarpong, Boateng Kofi
- Date: 1993
- Subjects: History -- Study and teaching (Secondary) -- South Africa--Ciskei -- Attitudes , History -- Study and teaching (Secondary) -- South Africa -- Ciskei
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1824 , http://hdl.handle.net/10962/d1003710 , History -- Study and teaching (Secondary) -- South Africa--Ciskei -- Attitudes , History -- Study and teaching (Secondary) -- South Africa -- Ciskei
- Description: This dissertation was motivated by the decline in percentage of the number of Standard 10 pupils who offered History for the National Senior Certificate (Matriculation) Examination in the Mathole Directorate in the Ciskei from 1987 - 1990. The research revealed that the decrease in the number of pupils doing History in Standard 10 did not indicate loss of interest in the subject. Instead, the multiplicity of new subjects introduced in the school curriculum and some peculiar subject combinations in some schools forced some pupils (reluctantly) to reject History as a school subject. Those who chose to do History in Standard 10 showed their liking for the subject and expressed their interest in it. The study took the form of a survey through the use of questionnaire and informal chats with pupils and teachers on their views about History as a school subject. A questionnaire was designed for pupils offering History in Standard 10 and administered in four of the eight Senior Secondary Schools in the Mathole Directorate in Ciskei. Generally, work on pupils' interest in and attitude towards History as a school subject is very rare. Some of the few available works merely compare pupils' liking for History as opposed to other school subjects and when the response is not favourable; conclude that pupils in Senior Secondary Schools do not enjoy studying History. Pupils' interest in and attitudes towards the subject, the extent of their interest, the causes of their attitude and the internal and external influences on their interest in and attitudes towards the subject were neglected by earlier works, but have been given attention in this study. As a result of very little available work and material, pupils' responses to the questionnaire formed the basis of the material used in this work. A large number of pupils' responses was put in tables according to sex instead of schools. Where applicable, X2 tests were administered to see if there were any appreciable statistically significant differences between the responses of the boys and girls. In most cases where the X2 tests were applied, no statistically difference was noticed. The study showed more boys than girls showing interest in and positive attitudes towards History. The general picture of the study showed a deviation from the view commonly expressed by other studies that pupils in modern Senior Secondary Schools do not like History. As this study revealed, it is not the subject itself that pupils did not like, but the way it is handled by some teachers and lack of teaching aids to concretise events. This leads to the role of Teacher Training Institutions: which must be to produce the versatile, duty-conscious and innovating History teacher to revolutionise History teaching to make History alive to pupils.
- Full Text:
- Date Issued: 1993
- Authors: Atuahene-Sarpong, Boateng Kofi
- Date: 1993
- Subjects: History -- Study and teaching (Secondary) -- South Africa--Ciskei -- Attitudes , History -- Study and teaching (Secondary) -- South Africa -- Ciskei
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1824 , http://hdl.handle.net/10962/d1003710 , History -- Study and teaching (Secondary) -- South Africa--Ciskei -- Attitudes , History -- Study and teaching (Secondary) -- South Africa -- Ciskei
- Description: This dissertation was motivated by the decline in percentage of the number of Standard 10 pupils who offered History for the National Senior Certificate (Matriculation) Examination in the Mathole Directorate in the Ciskei from 1987 - 1990. The research revealed that the decrease in the number of pupils doing History in Standard 10 did not indicate loss of interest in the subject. Instead, the multiplicity of new subjects introduced in the school curriculum and some peculiar subject combinations in some schools forced some pupils (reluctantly) to reject History as a school subject. Those who chose to do History in Standard 10 showed their liking for the subject and expressed their interest in it. The study took the form of a survey through the use of questionnaire and informal chats with pupils and teachers on their views about History as a school subject. A questionnaire was designed for pupils offering History in Standard 10 and administered in four of the eight Senior Secondary Schools in the Mathole Directorate in Ciskei. Generally, work on pupils' interest in and attitude towards History as a school subject is very rare. Some of the few available works merely compare pupils' liking for History as opposed to other school subjects and when the response is not favourable; conclude that pupils in Senior Secondary Schools do not enjoy studying History. Pupils' interest in and attitudes towards the subject, the extent of their interest, the causes of their attitude and the internal and external influences on their interest in and attitudes towards the subject were neglected by earlier works, but have been given attention in this study. As a result of very little available work and material, pupils' responses to the questionnaire formed the basis of the material used in this work. A large number of pupils' responses was put in tables according to sex instead of schools. Where applicable, X2 tests were administered to see if there were any appreciable statistically significant differences between the responses of the boys and girls. In most cases where the X2 tests were applied, no statistically difference was noticed. The study showed more boys than girls showing interest in and positive attitudes towards History. The general picture of the study showed a deviation from the view commonly expressed by other studies that pupils in modern Senior Secondary Schools do not like History. As this study revealed, it is not the subject itself that pupils did not like, but the way it is handled by some teachers and lack of teaching aids to concretise events. This leads to the role of Teacher Training Institutions: which must be to produce the versatile, duty-conscious and innovating History teacher to revolutionise History teaching to make History alive to pupils.
- Full Text:
- Date Issued: 1993
Investigations of the bioavailability/bioequivalence of topical corticosteroid formulations containing clobetasol propionate using the human skin blanching assay, tape stripping and microdialysis
- Authors: Au, Wai Ling
- Date: 2010
- Subjects: Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3743 , http://hdl.handle.net/10962/d1003221 , Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Description: Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment of those products, no other method has been “officially” approved for use in those investigations. However, a few alternative methods such as tape stripping and microdialysis have been pursued and considered to have the potential for use in ioequivalence/bioavailability studies. The human skin blanching assay was used to assess the bioequivalence of commercially available topical products containing 0.05% clobetasol propionate. Both visual and chromameter data were obtained and a commercially available topical corticosteroid product, Dermovate® cream was used as both the “Test” and the “Reference” product. The results indicated that both visual and chromametric assessments were comparable to each other and that either could be used for the assessment of the bioequivalence of topical products containing clobetasol propionate. The screening procedure was optimized to identify potential “detectors” for inclusion in the bioequivalence studies. This resulted in fewer subjects being required in a bioequivalence pivotal study, still having the necessary power to confirm bioequivalence using the human skin blanching assay. Another objective of this research was to re-visit tape stripping and other possible alternative methods such as dermal microdialysis and to optimize these procedures for bioequivalence assessment of topical formulations where the drug is not intended for systemic absorption. In the past few decades, tape stripping has been used to investigate bioavailability/bioequivalence of various topical formulations. This technique involves the removal of the stratum corneum to assess drug penetration through the skin. A draft FDA guidance for tape stripping was initially published but was subsequently withdrawn due to high variability and poor reproducibility. This research project used an optimized tape stripping procedure to determine bioavailability and establish bioequivalence between three commercially available formulations containing 0.05 % m/m clobetasol propionate. Furthermore, tape stripping was validated by undertaking a study to assess the bioequivalence of a 0.05% topical cream formulation (Dermovate® cream) using the same cream as both the “Test” and “Reference” product, in which bioequivalence was confirmed. The findings highlight the potential of tape stripping as an alternative method for the assessment of bioequivalence of clobetasol propionate formulations and may possibly be extended for use in other topical products. Microdialysis is another useful technique that can assess the penetration of topically applied substances which diffuses through the stratum corneum and into the dermis. Microdialysis has previously been successfully used for in vivo bioavailability and bioequivalence assessments of topical formulations. However, the drugs which were under investigation were all hydrophilic in nature. A major problem with the use of microdialysis for the assessment of lipophilic substances is the binding/adherence of the substance to the membrane and other components of the microdialysis system. As a result, this necessitates the development of a microdialysis system which can be used to assess lipophilic drugs. Intralipid® 20% was investigated and successfully utilized as a perfusate to recover a lipophilic topical corticosteroid, clobetasol propionate, in microdialysis studies. Hence, the bioavailability of clobetasol propionate from an extemporaneous preparation was determined in healthy human volunteers using microdialysis. These findings indicate that in vivo microdialysis can be used to assess lipophilic drug penetration through the skin. A novel approach to investigate drug release from topical formulations containing 0.05% clobetasol propionate using in vitro microdialysis was also undertaken. The in vitro findings were found to be in agreement with the results obtained using tape stripping to assess bioequivalence of the same commercially available products, namely Dermovate® cream, Dovate® Cream and Dermovate® ointment. These results indicate the potential to correlate in vitro with in vivo data for bioequivalence assessment of such topical dosage forms.
- Full Text:
- Date Issued: 2010
- Authors: Au, Wai Ling
- Date: 2010
- Subjects: Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3743 , http://hdl.handle.net/10962/d1003221 , Adrenocortical hormones -- Bioavailability , Drugs -- Therapeutic equivalency , Adrenocortical hormones -- Effectiveness , Adrenocortical hormones -- Testing , Adrenocortical hormones -- Side effects , Transdermal medication
- Description: Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment of those products, no other method has been “officially” approved for use in those investigations. However, a few alternative methods such as tape stripping and microdialysis have been pursued and considered to have the potential for use in ioequivalence/bioavailability studies. The human skin blanching assay was used to assess the bioequivalence of commercially available topical products containing 0.05% clobetasol propionate. Both visual and chromameter data were obtained and a commercially available topical corticosteroid product, Dermovate® cream was used as both the “Test” and the “Reference” product. The results indicated that both visual and chromametric assessments were comparable to each other and that either could be used for the assessment of the bioequivalence of topical products containing clobetasol propionate. The screening procedure was optimized to identify potential “detectors” for inclusion in the bioequivalence studies. This resulted in fewer subjects being required in a bioequivalence pivotal study, still having the necessary power to confirm bioequivalence using the human skin blanching assay. Another objective of this research was to re-visit tape stripping and other possible alternative methods such as dermal microdialysis and to optimize these procedures for bioequivalence assessment of topical formulations where the drug is not intended for systemic absorption. In the past few decades, tape stripping has been used to investigate bioavailability/bioequivalence of various topical formulations. This technique involves the removal of the stratum corneum to assess drug penetration through the skin. A draft FDA guidance for tape stripping was initially published but was subsequently withdrawn due to high variability and poor reproducibility. This research project used an optimized tape stripping procedure to determine bioavailability and establish bioequivalence between three commercially available formulations containing 0.05 % m/m clobetasol propionate. Furthermore, tape stripping was validated by undertaking a study to assess the bioequivalence of a 0.05% topical cream formulation (Dermovate® cream) using the same cream as both the “Test” and “Reference” product, in which bioequivalence was confirmed. The findings highlight the potential of tape stripping as an alternative method for the assessment of bioequivalence of clobetasol propionate formulations and may possibly be extended for use in other topical products. Microdialysis is another useful technique that can assess the penetration of topically applied substances which diffuses through the stratum corneum and into the dermis. Microdialysis has previously been successfully used for in vivo bioavailability and bioequivalence assessments of topical formulations. However, the drugs which were under investigation were all hydrophilic in nature. A major problem with the use of microdialysis for the assessment of lipophilic substances is the binding/adherence of the substance to the membrane and other components of the microdialysis system. As a result, this necessitates the development of a microdialysis system which can be used to assess lipophilic drugs. Intralipid® 20% was investigated and successfully utilized as a perfusate to recover a lipophilic topical corticosteroid, clobetasol propionate, in microdialysis studies. Hence, the bioavailability of clobetasol propionate from an extemporaneous preparation was determined in healthy human volunteers using microdialysis. These findings indicate that in vivo microdialysis can be used to assess lipophilic drug penetration through the skin. A novel approach to investigate drug release from topical formulations containing 0.05% clobetasol propionate using in vitro microdialysis was also undertaken. The in vitro findings were found to be in agreement with the results obtained using tape stripping to assess bioequivalence of the same commercially available products, namely Dermovate® cream, Dovate® Cream and Dermovate® ointment. These results indicate the potential to correlate in vitro with in vivo data for bioequivalence assessment of such topical dosage forms.
- Full Text:
- Date Issued: 2010
South African traditional healers’ perceptions and treatment of the symptoms of depression
- Authors: Augustine, Daniella Joan
- Date: 2023-03-30
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/408789 , vital:70525
- Description: While depression is experienced worldwide, the World Health Organization indicated that over 80% of this disease burden is found in low- and middle-income countries, with 16% of depressive disorder cases being found in Africa. Specifically, in South Africa, the lifetime prevalence of major depressive disorder is 9.7%. Research conducted on traditional healing estimates that as high as 80% of black individuals in South Africa choose to consult traditional healers. Although there was initial consensus that the use of traditional healers reflected a lack of access to alternative resources, more recent research has however indicated that traditional healers are consulted even when psychiatric facilities and medication are available. Research has illustrated that many patients that chose to consult traditional healers do so as a result of their shared beliefs, and traditional healers' ability to understand the cultural frameworks underlying illness. The current study investigated how traditional healers in the Eastern Cape perceive and treat phenomena currently understood as the symptoms of depression and how these understandings can be incorporated into collaborations between Western medicine and traditional healing practice. A qualitative research design was used to examine the perspectives and treatment methods of isiXhosa traditional healers in the Eastern Cape. Four healers participated in the study. Key findings indicated that there is no single cause or definition of the phenomenon of depression by healers. Causality is greatly attributed to spiritual causes and ancestors play a key role in guiding the diagnosis and multiple treatment interventions employed by healers to treat the experience of depression. Finally, all traditional healers expressed a willingness to collaborate and work with the Western healthcare system, however, they indicated a strong need for greater recognition as a valid healthcare system. , Thesis (MA) -- Faculty of Humanities, Psychology, 2023
- Full Text:
- Date Issued: 2023-03-30
- Authors: Augustine, Daniella Joan
- Date: 2023-03-30
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/408789 , vital:70525
- Description: While depression is experienced worldwide, the World Health Organization indicated that over 80% of this disease burden is found in low- and middle-income countries, with 16% of depressive disorder cases being found in Africa. Specifically, in South Africa, the lifetime prevalence of major depressive disorder is 9.7%. Research conducted on traditional healing estimates that as high as 80% of black individuals in South Africa choose to consult traditional healers. Although there was initial consensus that the use of traditional healers reflected a lack of access to alternative resources, more recent research has however indicated that traditional healers are consulted even when psychiatric facilities and medication are available. Research has illustrated that many patients that chose to consult traditional healers do so as a result of their shared beliefs, and traditional healers' ability to understand the cultural frameworks underlying illness. The current study investigated how traditional healers in the Eastern Cape perceive and treat phenomena currently understood as the symptoms of depression and how these understandings can be incorporated into collaborations between Western medicine and traditional healing practice. A qualitative research design was used to examine the perspectives and treatment methods of isiXhosa traditional healers in the Eastern Cape. Four healers participated in the study. Key findings indicated that there is no single cause or definition of the phenomenon of depression by healers. Causality is greatly attributed to spiritual causes and ancestors play a key role in guiding the diagnosis and multiple treatment interventions employed by healers to treat the experience of depression. Finally, all traditional healers expressed a willingness to collaborate and work with the Western healthcare system, however, they indicated a strong need for greater recognition as a valid healthcare system. , Thesis (MA) -- Faculty of Humanities, Psychology, 2023
- Full Text:
- Date Issued: 2023-03-30
An investigation into the persistence of traditional teaching methods in grade 9 mathematics classrooms in Rundu : a case study
- Authors: Ausiku, Charity M
- Date: 2009
- Subjects: Mathematics -- Study and teaching (Secondary) -- Namibia -- Case studies Mathematics teachers -- Training of -- Namibia -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1852 , http://hdl.handle.net/10962/d1004461
- Description: I embarked upon this study to investigate mathematics teachers' practices that have led to the persistence of traditional teaching methods in grade 9 mathematics classrooms in Rundu. The study was conducted from a learner-centred (L-C) perspective or reform approach in the Namibian context. It is a qualitative study oriented in the interpretive paradigm- a paradigm that seeks to understand the meanings attached to human actions. The participants involved in this study were purposively selected and they are composed of two mathematics teachers and their grade 9 learners. This study was conducted at two schools in Rundu. One is an urban school while the other one is a rural school on the outskirts of Rundu. The research tools employed in this study are questionnaires, interviews and observations. The questionnaires were used to identify and select my participants while the observations were used to investigate the participants teaching strategies. The purpose of the interviews was mainly to investigate teachers' understanding, interpretation and implementation of learner-centre education (LCE). Amongst other findings, this study reveals that inadequate teacher-training, controversial educational policies and challenges such as overcrowdedness in mathematics classrooms, lack of teaching and learning materials, lack of cooperation among mathematics teachers and learners' negative attitude towards mathematics are some of the contributing factors to the persistence of traditional teaching methods in mathematics classrooms. Moreover, the study reveals that the persistence of traditional teaching methods in mathematics classes can no longer be attributed to the lack of understanding of LCE. The teachers in this study seem to be well acquainted with the theoretical aspect of the LCE framework while the implementation aspect seems to be a concern.
- Full Text:
- Date Issued: 2009
- Authors: Ausiku, Charity M
- Date: 2009
- Subjects: Mathematics -- Study and teaching (Secondary) -- Namibia -- Case studies Mathematics teachers -- Training of -- Namibia -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1852 , http://hdl.handle.net/10962/d1004461
- Description: I embarked upon this study to investigate mathematics teachers' practices that have led to the persistence of traditional teaching methods in grade 9 mathematics classrooms in Rundu. The study was conducted from a learner-centred (L-C) perspective or reform approach in the Namibian context. It is a qualitative study oriented in the interpretive paradigm- a paradigm that seeks to understand the meanings attached to human actions. The participants involved in this study were purposively selected and they are composed of two mathematics teachers and their grade 9 learners. This study was conducted at two schools in Rundu. One is an urban school while the other one is a rural school on the outskirts of Rundu. The research tools employed in this study are questionnaires, interviews and observations. The questionnaires were used to identify and select my participants while the observations were used to investigate the participants teaching strategies. The purpose of the interviews was mainly to investigate teachers' understanding, interpretation and implementation of learner-centre education (LCE). Amongst other findings, this study reveals that inadequate teacher-training, controversial educational policies and challenges such as overcrowdedness in mathematics classrooms, lack of teaching and learning materials, lack of cooperation among mathematics teachers and learners' negative attitude towards mathematics are some of the contributing factors to the persistence of traditional teaching methods in mathematics classrooms. Moreover, the study reveals that the persistence of traditional teaching methods in mathematics classes can no longer be attributed to the lack of understanding of LCE. The teachers in this study seem to be well acquainted with the theoretical aspect of the LCE framework while the implementation aspect seems to be a concern.
- Full Text:
- Date Issued: 2009
The role of visualisation in redefining the pedagogy of fractions in mathematics classrooms among senior primary school teachers
- Authors: Ausiku, Charity Makwiliro
- Date: 2022-10-14
- Subjects: Mathematics Study and teaching (Elementary) Namibia , Fractions Study and teaching (Elementary) Namibia , Visualization , Visual learning , Dual-coding hypothesis , Constructivism (Education) Namibia
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/405456 , vital:70173 , DOI 10.21504/10962/405456
- Description: This mixed methods study explored the impact of the use of a visualisation approach on the pedagogy of eight teacher participants who were involved in the Rundu Campus Fraction Project (RCFP). The aim of this study was to determine the extent to which participants incorporated visualisation processes in the pedagogy of fractions, in view of their exposure to visualisation activities in the RCFP. Since fractions are difficult to teach and learn, visualisation was considered as an alternative approach to the pedagogy of fractions because it presents learners with opportunities to improve their proportional and spatial reasoning. This study was founded on the premise that the incorporation of both verbal and nonverbal cues can enhance the teaching and learning of fractions rather than the use of a single cue. Hence, the two theories underpinning this study are the Dual Coding Theory and the Constructivist Theory. While the Dual Coding Theory advocates for the use of verbal and nonverbal codes, the Constructivist theory states that meaningful learning occurs when learners are presented with opportunities to construct their own knowledge. Thus, the two codes are intertwined. In other words, the active construction of knowledge among learners is aided by using constructivist teaching approaches through the incorporation of both verbal and nonverbal codes. Although this study was predominantly qualitative, quantitative methods were also used in the data collection process. A questionnaire was administered to identify teacher participants for this study, based on their teaching orientations. Their views on best practices in mathematics classrooms in general and the incorporation of visualisation processes in particular, were instrumental in the selection of participants for this study. In addition, observations and semi-structured interviews were also used as research methods. Twenty-five lesson samples were video recorded, transcribed and analysed using both qualitative and quantitative methods. Moreover, each of the eight participants was exposed to a set of pre- and post-observation interviews during which they were expected to express their views on the selection, incorporation and impact of visualisation processes on the teaching of fractions. Data sets from all three instruments were analysed using both quantitative and qualitative methods. The findings indicate that the RCFP had an impact on the teaching strategies employed by the participants as they all incorporated visualisation processes into their teaching to some extent. In some lessons, the visual code was effectively blended into the verbal code while in others, the purpose of and connection between the two codes was not evident. Hence, although all the participants embraced the incorporation of visualisation in the pedagogy of mathematics, some of them struggled to find its rightful position in the teaching of fractions. The findings suggest that despite the participants’ eagerness to use visualisation in their fraction lessons, some of them did not have adequate knowledge to successfully merge it with the conventional verbal code. Thus, for the integration of visuals to be impactful, it should be carefully merged in the teaching of fractions by taking into account various factors. , Thesis (PhD) -- Faculty of Education, Education, 2022
- Full Text:
- Date Issued: 2022-10-14
- Authors: Ausiku, Charity Makwiliro
- Date: 2022-10-14
- Subjects: Mathematics Study and teaching (Elementary) Namibia , Fractions Study and teaching (Elementary) Namibia , Visualization , Visual learning , Dual-coding hypothesis , Constructivism (Education) Namibia
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/405456 , vital:70173 , DOI 10.21504/10962/405456
- Description: This mixed methods study explored the impact of the use of a visualisation approach on the pedagogy of eight teacher participants who were involved in the Rundu Campus Fraction Project (RCFP). The aim of this study was to determine the extent to which participants incorporated visualisation processes in the pedagogy of fractions, in view of their exposure to visualisation activities in the RCFP. Since fractions are difficult to teach and learn, visualisation was considered as an alternative approach to the pedagogy of fractions because it presents learners with opportunities to improve their proportional and spatial reasoning. This study was founded on the premise that the incorporation of both verbal and nonverbal cues can enhance the teaching and learning of fractions rather than the use of a single cue. Hence, the two theories underpinning this study are the Dual Coding Theory and the Constructivist Theory. While the Dual Coding Theory advocates for the use of verbal and nonverbal codes, the Constructivist theory states that meaningful learning occurs when learners are presented with opportunities to construct their own knowledge. Thus, the two codes are intertwined. In other words, the active construction of knowledge among learners is aided by using constructivist teaching approaches through the incorporation of both verbal and nonverbal codes. Although this study was predominantly qualitative, quantitative methods were also used in the data collection process. A questionnaire was administered to identify teacher participants for this study, based on their teaching orientations. Their views on best practices in mathematics classrooms in general and the incorporation of visualisation processes in particular, were instrumental in the selection of participants for this study. In addition, observations and semi-structured interviews were also used as research methods. Twenty-five lesson samples were video recorded, transcribed and analysed using both qualitative and quantitative methods. Moreover, each of the eight participants was exposed to a set of pre- and post-observation interviews during which they were expected to express their views on the selection, incorporation and impact of visualisation processes on the teaching of fractions. Data sets from all three instruments were analysed using both quantitative and qualitative methods. The findings indicate that the RCFP had an impact on the teaching strategies employed by the participants as they all incorporated visualisation processes into their teaching to some extent. In some lessons, the visual code was effectively blended into the verbal code while in others, the purpose of and connection between the two codes was not evident. Hence, although all the participants embraced the incorporation of visualisation in the pedagogy of mathematics, some of them struggled to find its rightful position in the teaching of fractions. The findings suggest that despite the participants’ eagerness to use visualisation in their fraction lessons, some of them did not have adequate knowledge to successfully merge it with the conventional verbal code. Thus, for the integration of visuals to be impactful, it should be carefully merged in the teaching of fractions by taking into account various factors. , Thesis (PhD) -- Faculty of Education, Education, 2022
- Full Text:
- Date Issued: 2022-10-14
Grade 10 life science teachers' understanding and development of critical thinking skills in selected schools in Namibia
- Authors: Avia, Ndiyakuphi
- Date: 2009
- Subjects: Education -- Namibia Life sciences -- Study and teaching (Secondary) -- Namibia Critical thinking -- Study and teaching (Secondary) -- Namibia Education -- Curricula -- Namibia Educational change -- Namibia Teachers -- Training of -- Namibia
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1550 , http://hdl.handle.net/10962/d1003432
- Description: The educational reform policy in Namibia adopted the principles and practice of learner-centred education, a policy based on constructivist epistemology. This approach emphasises that learners are constructors of knowledge and that they must discover information and construct their own learning. Constructivist techniques require the use of critical thinking through learners’ active involvement in the learning process. The aim is for learners to use critical thinking to identify problems, ask questions, reason, examine and solve problems in real situations and make sound decisions. This approach provides learners with activities and experiences that stimulate them to learn to think for themselves and to ask questions. Therefore, teachers need to design activities that require learners to think critically and act independently through mastering these various modes of inquiry. The purpose of this study was to explore how the selected Grade 10 Life Science teachers understand and implement critical thinking in their teaching practice. I conducted the study in two secondary schools from the Omusati region in Namibia using a case study to gain insight into the implementation of critical thinking. Three data collection instruments: interviews, document analysis and class observations were used. The reason for conducting this study was to gain a better understanding of how teachers use various strategies to foster critical thinking skills in Life Science and the challenges they experience in teaching in secondary schools. The results of the study revealed that teachers have a theoretical understanding of what critical thinking implies and the role it plays in learning. They are also aware of the strategies used to develop critical thinking skills. However, these theoretical perspectives do not reflect in their teaching in that some of the strategies that the teachers used did not bring about meaningful learning. Learners are still required to recall factual knowledge, thus active involvement of the learners is limited. The study also revealed that there are specific issues that hamper the implementation of critical thinking, which include superficial understanding of learner-centered education, teacher-tell approach, overcrowded curriculum, inexplicit syllabus, lack of good examples from the textbooks and examinations, too short lesson periods, lack of language proficiency and lack of professional development. The findings indicate that despite the theoretical understanding of the teachers in this study, their actual practice of developing critical thinking skills is problematic. The study concludes that teachers should be encouraged to design better-structured activities in order to involve learners beyond just being listeners. In light of these findings, the study recognizes a need for ongoing in-service professional development to support teachers in modelling critical thinking to their learners and to teach them to think critically. The findings of the study will serve to inform both my and my colleague’s professional practice as advisory teachers with regard to what to focus on when advising and supporting the teachers in schools.
- Full Text:
- Date Issued: 2009
- Authors: Avia, Ndiyakuphi
- Date: 2009
- Subjects: Education -- Namibia Life sciences -- Study and teaching (Secondary) -- Namibia Critical thinking -- Study and teaching (Secondary) -- Namibia Education -- Curricula -- Namibia Educational change -- Namibia Teachers -- Training of -- Namibia
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1550 , http://hdl.handle.net/10962/d1003432
- Description: The educational reform policy in Namibia adopted the principles and practice of learner-centred education, a policy based on constructivist epistemology. This approach emphasises that learners are constructors of knowledge and that they must discover information and construct their own learning. Constructivist techniques require the use of critical thinking through learners’ active involvement in the learning process. The aim is for learners to use critical thinking to identify problems, ask questions, reason, examine and solve problems in real situations and make sound decisions. This approach provides learners with activities and experiences that stimulate them to learn to think for themselves and to ask questions. Therefore, teachers need to design activities that require learners to think critically and act independently through mastering these various modes of inquiry. The purpose of this study was to explore how the selected Grade 10 Life Science teachers understand and implement critical thinking in their teaching practice. I conducted the study in two secondary schools from the Omusati region in Namibia using a case study to gain insight into the implementation of critical thinking. Three data collection instruments: interviews, document analysis and class observations were used. The reason for conducting this study was to gain a better understanding of how teachers use various strategies to foster critical thinking skills in Life Science and the challenges they experience in teaching in secondary schools. The results of the study revealed that teachers have a theoretical understanding of what critical thinking implies and the role it plays in learning. They are also aware of the strategies used to develop critical thinking skills. However, these theoretical perspectives do not reflect in their teaching in that some of the strategies that the teachers used did not bring about meaningful learning. Learners are still required to recall factual knowledge, thus active involvement of the learners is limited. The study also revealed that there are specific issues that hamper the implementation of critical thinking, which include superficial understanding of learner-centered education, teacher-tell approach, overcrowded curriculum, inexplicit syllabus, lack of good examples from the textbooks and examinations, too short lesson periods, lack of language proficiency and lack of professional development. The findings indicate that despite the theoretical understanding of the teachers in this study, their actual practice of developing critical thinking skills is problematic. The study concludes that teachers should be encouraged to design better-structured activities in order to involve learners beyond just being listeners. In light of these findings, the study recognizes a need for ongoing in-service professional development to support teachers in modelling critical thinking to their learners and to teach them to think critically. The findings of the study will serve to inform both my and my colleague’s professional practice as advisory teachers with regard to what to focus on when advising and supporting the teachers in schools.
- Full Text:
- Date Issued: 2009
Coastal dune ecology and management in the Eastern Cape
- Authors: Avis, Anthony Mark
- Date: 1993
- Subjects: Sand dune ecology -- South Africa Shore protection -- South Africa Coastal zone management -- South Africa Sand dunes -- South Africa Sand dune plants -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4185 , http://hdl.handle.net/10962/d1003753
- Description: The importance of understanding the ecological functioning of coastal dune systems is emphasized as being fundamental to the correct management of the dune landscape. Dune vegetation along the Eastern Cape coastline, from Cape St Francis in the west to Kei Mouth in the east was described in terms of the distribution and phytochorological affinities of the taxa. At a regional scale species distribution was strongly influenced by both the climate, particularly rainfall, and the phytochorological affinities of the taxa. Seven communities were defined using TWINSPAN, and the interrelationships between these communities in anyone area appeared to be linked to a successional gradient. Dune Slacks are thought to play a key role in this successional sequence, and a temporal study of this community led to a conceptual model of plant succession in these dunefields. Climate, particularly rainfall and wind, are major factors influencing plant succession. Wind-borne sand causes the slacks to migrate in an easterly direction under the influence of the predominantly westerly winds, although easterly winds, mainly in summer months may reverse these trends. Autogenic changes appeared to be important in this succession, and a comparative study of a good example of a primary succession at Mtunzini in Natal was undertaken to elucidate the main mechanism of change. Eight communities that were identified here were concluded to be distnbuted along a gradient of increasing age, with successional changes predictable, linear and directional. Species were grouped in distinct zones along the continuum and edaphic changes (decrease in soil pH, increase in organic matter and exchangeable bases) were related to the community based changes in species composition. The mechanism of change supported the facilitation model of plant succession which is a modification of the original Clementsian concept. Similar results were found in the Eastern Cape, but due to the harsh environment, multiple pathways of succession exist. Data from this study lent support to the model of plant succession developed earlier, and confinned that the dune slacks played an important role in this facilitation by acting as centres of diversity. The foredunes were found to have an indirect role in protecting these slacks from salt spray and sand movement. The central theme of the management studies was to investigate the ecological consequences of recreational pressure within the dune environment. Current levels of beach utilization at East London were lower than other beaches in South Africa, but a general trend of increasing utilization due to sociopolitical changes can be expected. The suitability of questionnaire surveys to assess aspects such as the adequacy of facilities, perceptual carrying capacity and the beach users opinion of natural vegetation and preference for particular beaches was demonstrated. The dune vegetation was found to be sensitive to human trampling, but at current levels, the ecological carrying capacity will not be exceeded since results of the aerial census counts and questionnaire survey revealed that few people entered sensitive zones such as the coastal forest. More detailed long term studies on the susceptibility of dune vegetation to both trampling and off-road vehicle impacts revealed a low resilience of dune plant communities to these effects. Although susceptibility differed between the three communities tested, generally the greatest amount of damage occurred after the first few passages, and vehicles caused a more significant decrease in height when compared to trampling. Recovery rates were slow and low levels of repeated damage were sufficient to retard or prevent the recovery of the plants. Stricter control of vehicle use on beaches is therefore required, and in high use zones the ecological carrying capacity should be increased by providing access tracks if possible, or if not possible, by restricting access. A historical account of the process of dune stabilization showed that although first initiated in 1845, indigenous species were only used in the past three decades. The use of alien species has resulted in problems such as a reduction in the ecological integrity and aesthetic appeal of coastal systems. The techniques applied in the stabilization of drift sands with indigenous vegetation have been successful, as revealed by a quantitative survey of 17 sites in the Eastern Cape. Sites were grouped by multivariate analysis on the basis of their species composition, and variability between sites was dependent on the types of species planted. Selection of suitable species is therefore important and is discussed with respect to their natural distribution along the coast. The long term objective of stabilization should be the creation of functional, diverse, aesthetic ecosystems, since the intrinsic and economic value of the dune landscape for tourism lies therein. However, detailed studies should be undertaken prior to implementing a manipulative process such as dune stabilization, since ecological processes may be disrupted. An understanding of such processes is therefore important if one wishes to effectively manage the dune landscape.
- Full Text:
- Date Issued: 1993
- Authors: Avis, Anthony Mark
- Date: 1993
- Subjects: Sand dune ecology -- South Africa Shore protection -- South Africa Coastal zone management -- South Africa Sand dunes -- South Africa Sand dune plants -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4185 , http://hdl.handle.net/10962/d1003753
- Description: The importance of understanding the ecological functioning of coastal dune systems is emphasized as being fundamental to the correct management of the dune landscape. Dune vegetation along the Eastern Cape coastline, from Cape St Francis in the west to Kei Mouth in the east was described in terms of the distribution and phytochorological affinities of the taxa. At a regional scale species distribution was strongly influenced by both the climate, particularly rainfall, and the phytochorological affinities of the taxa. Seven communities were defined using TWINSPAN, and the interrelationships between these communities in anyone area appeared to be linked to a successional gradient. Dune Slacks are thought to play a key role in this successional sequence, and a temporal study of this community led to a conceptual model of plant succession in these dunefields. Climate, particularly rainfall and wind, are major factors influencing plant succession. Wind-borne sand causes the slacks to migrate in an easterly direction under the influence of the predominantly westerly winds, although easterly winds, mainly in summer months may reverse these trends. Autogenic changes appeared to be important in this succession, and a comparative study of a good example of a primary succession at Mtunzini in Natal was undertaken to elucidate the main mechanism of change. Eight communities that were identified here were concluded to be distnbuted along a gradient of increasing age, with successional changes predictable, linear and directional. Species were grouped in distinct zones along the continuum and edaphic changes (decrease in soil pH, increase in organic matter and exchangeable bases) were related to the community based changes in species composition. The mechanism of change supported the facilitation model of plant succession which is a modification of the original Clementsian concept. Similar results were found in the Eastern Cape, but due to the harsh environment, multiple pathways of succession exist. Data from this study lent support to the model of plant succession developed earlier, and confinned that the dune slacks played an important role in this facilitation by acting as centres of diversity. The foredunes were found to have an indirect role in protecting these slacks from salt spray and sand movement. The central theme of the management studies was to investigate the ecological consequences of recreational pressure within the dune environment. Current levels of beach utilization at East London were lower than other beaches in South Africa, but a general trend of increasing utilization due to sociopolitical changes can be expected. The suitability of questionnaire surveys to assess aspects such as the adequacy of facilities, perceptual carrying capacity and the beach users opinion of natural vegetation and preference for particular beaches was demonstrated. The dune vegetation was found to be sensitive to human trampling, but at current levels, the ecological carrying capacity will not be exceeded since results of the aerial census counts and questionnaire survey revealed that few people entered sensitive zones such as the coastal forest. More detailed long term studies on the susceptibility of dune vegetation to both trampling and off-road vehicle impacts revealed a low resilience of dune plant communities to these effects. Although susceptibility differed between the three communities tested, generally the greatest amount of damage occurred after the first few passages, and vehicles caused a more significant decrease in height when compared to trampling. Recovery rates were slow and low levels of repeated damage were sufficient to retard or prevent the recovery of the plants. Stricter control of vehicle use on beaches is therefore required, and in high use zones the ecological carrying capacity should be increased by providing access tracks if possible, or if not possible, by restricting access. A historical account of the process of dune stabilization showed that although first initiated in 1845, indigenous species were only used in the past three decades. The use of alien species has resulted in problems such as a reduction in the ecological integrity and aesthetic appeal of coastal systems. The techniques applied in the stabilization of drift sands with indigenous vegetation have been successful, as revealed by a quantitative survey of 17 sites in the Eastern Cape. Sites were grouped by multivariate analysis on the basis of their species composition, and variability between sites was dependent on the types of species planted. Selection of suitable species is therefore important and is discussed with respect to their natural distribution along the coast. The long term objective of stabilization should be the creation of functional, diverse, aesthetic ecosystems, since the intrinsic and economic value of the dune landscape for tourism lies therein. However, detailed studies should be undertaken prior to implementing a manipulative process such as dune stabilization, since ecological processes may be disrupted. An understanding of such processes is therefore important if one wishes to effectively manage the dune landscape.
- Full Text:
- Date Issued: 1993
WISC-R coding incidental recall, digit span and supraspan test performance in children aged 6 and 7
- Authors: Avis, Cheryl Esme
- Date: 1995
- Subjects: Wechsler Intelligence Scale for Children
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3155 , http://hdl.handle.net/10962/d1007506 , Wechsler Intelligence Scale for Children
- Description: The primary aim of this study was to develop age-related normative data for the WISC-R Digits Forward, Digits Backward, Digits Difference, Digit Supraspan, and Coding Incidental Recall (Immediate and 30' Delayed) tests for a non-clinical population of South African school children aged 6 and 7. The effects of sex, English versus Xhosa language, and white versus black race groups, were additional investigations. Subjects were randomly selected from three English speaking Grahamstown schools; level of education ranged from pre-school to Sub Standard B; English speaking subjects included predominantly white children, with a small proportion of coloured, Chinese and Indian children; Xhosa speaking children were all black. Interim normative data on all tests across two age groups (6 and 7) are presented, and are considered reliable and diagnostically useful in clinical neuropsychological assessment. There were no significant effects for age, sex, English versus Xhosa language or white versus black race groups, on any of the tests with the exception of Digits Backward which yielded marginally lower scores for black Subjects. Although the mean IQ estimate based on the Draw-A-Person test was equivalent across age, sex, English versus Xhosa language and white versus black race groups, an intelligence rating of subjects by teachers revealed that black subjects were evaluated significantly lower than white subjects. This suggests the presence of prejudicial racial attitudes amongst educators in these predominantly English speaking white schools.
- Full Text:
- Date Issued: 1995
- Authors: Avis, Cheryl Esme
- Date: 1995
- Subjects: Wechsler Intelligence Scale for Children
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3155 , http://hdl.handle.net/10962/d1007506 , Wechsler Intelligence Scale for Children
- Description: The primary aim of this study was to develop age-related normative data for the WISC-R Digits Forward, Digits Backward, Digits Difference, Digit Supraspan, and Coding Incidental Recall (Immediate and 30' Delayed) tests for a non-clinical population of South African school children aged 6 and 7. The effects of sex, English versus Xhosa language, and white versus black race groups, were additional investigations. Subjects were randomly selected from three English speaking Grahamstown schools; level of education ranged from pre-school to Sub Standard B; English speaking subjects included predominantly white children, with a small proportion of coloured, Chinese and Indian children; Xhosa speaking children were all black. Interim normative data on all tests across two age groups (6 and 7) are presented, and are considered reliable and diagnostically useful in clinical neuropsychological assessment. There were no significant effects for age, sex, English versus Xhosa language or white versus black race groups, on any of the tests with the exception of Digits Backward which yielded marginally lower scores for black Subjects. Although the mean IQ estimate based on the Draw-A-Person test was equivalent across age, sex, English versus Xhosa language and white versus black race groups, an intelligence rating of subjects by teachers revealed that black subjects were evaluated significantly lower than white subjects. This suggests the presence of prejudicial racial attitudes amongst educators in these predominantly English speaking white schools.
- Full Text:
- Date Issued: 1995
Regulation of the indoleamines by sex steroids
- Authors: Awah, Edmund Kpabi
- Date: 1992
- Subjects: Steroids -- Research , Steroid drugs -- Research
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4053 , http://hdl.handle.net/10962/d1004114 , Steroids -- Research , Steroid drugs -- Research
- Description: Alteration of serum tryptophan leads to parallel alterations in brain tryptophan levels. Such changes in brain tryptophan levels has been shown to lead to mood disturbances. The primary enzyme responsible for altering serum tryptophan levels is the liver cytosolic enzyme, tryptophan pyrrolase. Activation of this enzyme is responsible for the enhanced catabolism of circulating tryptophan. The purpose of the present study was firstly to establish whether there is a link between sex steroids and tryptophan pyrrolase activity especially since sex steroids are also known to cause mood disturbances and secondly to determine the effects of sex steroids on brain indolamine metabolism. The results show that all three sex steroids induce the activity of tryptophan pyrrolase implying that they decrease serum tryptophan levels by the activation of tryptophan pyrrolase, thus making less tryptophan available for uptake by the brain. It was also shown that the sex steroids enhance the uptake of ¹⁴C-tryptophan by brain synatopsomes. In addition, the sex steroids influenced the pattern of metabolism of serotonin by organ cultures of rat pineal glands. It is possible that the sex steroids regulate the availability and uptake of indoleamines in the brain.
- Full Text:
- Date Issued: 1992
- Authors: Awah, Edmund Kpabi
- Date: 1992
- Subjects: Steroids -- Research , Steroid drugs -- Research
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4053 , http://hdl.handle.net/10962/d1004114 , Steroids -- Research , Steroid drugs -- Research
- Description: Alteration of serum tryptophan leads to parallel alterations in brain tryptophan levels. Such changes in brain tryptophan levels has been shown to lead to mood disturbances. The primary enzyme responsible for altering serum tryptophan levels is the liver cytosolic enzyme, tryptophan pyrrolase. Activation of this enzyme is responsible for the enhanced catabolism of circulating tryptophan. The purpose of the present study was firstly to establish whether there is a link between sex steroids and tryptophan pyrrolase activity especially since sex steroids are also known to cause mood disturbances and secondly to determine the effects of sex steroids on brain indolamine metabolism. The results show that all three sex steroids induce the activity of tryptophan pyrrolase implying that they decrease serum tryptophan levels by the activation of tryptophan pyrrolase, thus making less tryptophan available for uptake by the brain. It was also shown that the sex steroids enhance the uptake of ¹⁴C-tryptophan by brain synatopsomes. In addition, the sex steroids influenced the pattern of metabolism of serotonin by organ cultures of rat pineal glands. It is possible that the sex steroids regulate the availability and uptake of indoleamines in the brain.
- Full Text:
- Date Issued: 1992
An investigation into the organisational culture at an academically successful secondary school in Namibia
- Authors: Awarab, Erwin Ronald
- Date: 2010
- Subjects: Corporate culture -- Namibia -- Case studies Organizational behavior -- Namibia -- Case studies School management and organization -- Namibia -- Case studies Educational leadership -- Namibia -- Case studies Education, Secondary -- Namibia -- Case studies Educational change -- Namibia -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1612 , http://hdl.handle.net/10962/d1003494
- Description: The appreciation by leadership of the culture of an organisation plays an important role in the success of that organisation. Leadership and organisation culture are an inextricable part of the life of an organisation. The shared assumptions and beliefs of the individual within an organisation shape its culture. My study investigates the aspects of school culture and, further, looks at its link to the success of an organisation, and at the leadership style that influences such an organisation. My research, conducted in the interpretive paradigm, is a case study which was carried out at a public secondary school in the capital city of Windhoek, in Namibia. Since the school was built during South African rule, it was intended mainly for white children. Since independence, it has undergone transformation and is currently integrated, accommodating learners from different cultural backgrounds. It is a successful school, with a good reputation for its discipline and academic excellence. I chose this school deliberately, for those reasons. My findings are that there are aspects of culture which maintain its creation and perpetuate the existence of a particular culture at the school. This school’s culture is embedded within the Christian faith, and there are deliberate rituals and ceremonies put in place to enhance the creation and maintenance of the values that inform its culture, and the school leadership, management, teachers and student council members have a central role in this regard. My study shows that the creation, understanding and appreciation of beliefs and values of the individual within the organisation enable the consequent creation of the shared vision and values that ultimately lead to the foundation and maintenance of a strong culture.
- Full Text:
- Date Issued: 2010
- Authors: Awarab, Erwin Ronald
- Date: 2010
- Subjects: Corporate culture -- Namibia -- Case studies Organizational behavior -- Namibia -- Case studies School management and organization -- Namibia -- Case studies Educational leadership -- Namibia -- Case studies Education, Secondary -- Namibia -- Case studies Educational change -- Namibia -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1612 , http://hdl.handle.net/10962/d1003494
- Description: The appreciation by leadership of the culture of an organisation plays an important role in the success of that organisation. Leadership and organisation culture are an inextricable part of the life of an organisation. The shared assumptions and beliefs of the individual within an organisation shape its culture. My study investigates the aspects of school culture and, further, looks at its link to the success of an organisation, and at the leadership style that influences such an organisation. My research, conducted in the interpretive paradigm, is a case study which was carried out at a public secondary school in the capital city of Windhoek, in Namibia. Since the school was built during South African rule, it was intended mainly for white children. Since independence, it has undergone transformation and is currently integrated, accommodating learners from different cultural backgrounds. It is a successful school, with a good reputation for its discipline and academic excellence. I chose this school deliberately, for those reasons. My findings are that there are aspects of culture which maintain its creation and perpetuate the existence of a particular culture at the school. This school’s culture is embedded within the Christian faith, and there are deliberate rituals and ceremonies put in place to enhance the creation and maintenance of the values that inform its culture, and the school leadership, management, teachers and student council members have a central role in this regard. My study shows that the creation, understanding and appreciation of beliefs and values of the individual within the organisation enable the consequent creation of the shared vision and values that ultimately lead to the foundation and maintenance of a strong culture.
- Full Text:
- Date Issued: 2010
Development of styrene based imprinted sorbents for selective clean-up of metalloporphyrins in organic media
- Authors: Awokoya, Kehinde Nurudeen
- Date: 2014
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/54521 , vital:26580
- Description: Most crude oils contain traces of vanadium and nickel complex with porphyrins (VTPP and NTPP) within their asphaltene fraction. Although these metals are only present in trace quantities, they have a significant and detrimental impact on the refining process by degrading the quality of intermediate and end products. Therefore, their selective removal is highly desirable. This thesis presents the development of nickel porphyrin, nickel vanadyl porphyrin imprinted nanofibers and vanadyl porphyrin imprinted polymer (MIP) particles for application as selective sorbents. Computational model based on the combination of molecular dynamics simulations and quantum mechanics was successfully applied to the styrene functional monomer selection. The particle was prepared by bulk polymerization and the nanofibers by a novel approach combining molecular imprinting and electrospinning technology. The morphologies, thermal stabilities and porosities of the imprinted sorbents were studied using SEM, TGA, and BET nitrogen gas adsorption. Chloroform was found to swell the polymer particles to a higher degree than methanol and acetonitrile. The adsorption characteristics of the imprinted sorbents best fitted with Freundlich isotherm model. The imprinted sorbents recorded high extraction efficiencies (EEs) of > 99 % in selectively extracting the metalloporphyrins. The impact of the template on the affinity of recognition for NTPP was evaluated. The results showed that the NTPP adsorption capacity increased as the molar ratio of NTPP to styrene was increased from 1:1 to 3:1. The optimal ratio of template to functional monomer which yielded the best specific affinity and highest recovery (99.9 %) was 3:1. The effects of trifluoroacetic acid (TFA), dichloromethane (DCM), dimethyl sulphoxide (DMSO), pentane (PEN) on electro-spinnability of the polymer solutions and the morphological appearance of the nanofibers were investigated. The imprinted nanofibers exhibited the same selectivity specialism for both NTPP and VTPP. A remarkable stability in relation to reusability was observed when imprinted nanofibers were used, as they could be reused nine times without incurring any significant loss in removal efficiency. The results were validated by analysing a certified reference material. The imprinted sorbents were therefore found to be selective sorbents that are well suited for handling trace metals in organic media.
- Full Text:
- Date Issued: 2014
- Authors: Awokoya, Kehinde Nurudeen
- Date: 2014
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/54521 , vital:26580
- Description: Most crude oils contain traces of vanadium and nickel complex with porphyrins (VTPP and NTPP) within their asphaltene fraction. Although these metals are only present in trace quantities, they have a significant and detrimental impact on the refining process by degrading the quality of intermediate and end products. Therefore, their selective removal is highly desirable. This thesis presents the development of nickel porphyrin, nickel vanadyl porphyrin imprinted nanofibers and vanadyl porphyrin imprinted polymer (MIP) particles for application as selective sorbents. Computational model based on the combination of molecular dynamics simulations and quantum mechanics was successfully applied to the styrene functional monomer selection. The particle was prepared by bulk polymerization and the nanofibers by a novel approach combining molecular imprinting and electrospinning technology. The morphologies, thermal stabilities and porosities of the imprinted sorbents were studied using SEM, TGA, and BET nitrogen gas adsorption. Chloroform was found to swell the polymer particles to a higher degree than methanol and acetonitrile. The adsorption characteristics of the imprinted sorbents best fitted with Freundlich isotherm model. The imprinted sorbents recorded high extraction efficiencies (EEs) of > 99 % in selectively extracting the metalloporphyrins. The impact of the template on the affinity of recognition for NTPP was evaluated. The results showed that the NTPP adsorption capacity increased as the molar ratio of NTPP to styrene was increased from 1:1 to 3:1. The optimal ratio of template to functional monomer which yielded the best specific affinity and highest recovery (99.9 %) was 3:1. The effects of trifluoroacetic acid (TFA), dichloromethane (DCM), dimethyl sulphoxide (DMSO), pentane (PEN) on electro-spinnability of the polymer solutions and the morphological appearance of the nanofibers were investigated. The imprinted nanofibers exhibited the same selectivity specialism for both NTPP and VTPP. A remarkable stability in relation to reusability was observed when imprinted nanofibers were used, as they could be reused nine times without incurring any significant loss in removal efficiency. The results were validated by analysing a certified reference material. The imprinted sorbents were therefore found to be selective sorbents that are well suited for handling trace metals in organic media.
- Full Text:
- Date Issued: 2014
Between past and future: memory and mourning in the stories of Okwiri Oduor and Ndinda Kioko
- Authors: Awuor, Nicholas Amol
- Date: 2020
- Subjects: Oduor, Okwiri -- Criticism and interpretation , Oduor, Okwiri -- The plea bargain , Oduor, Okwiri -- My father's head , Oduor, Okwiri -- Rag doll , Kioko, Ndinda -- Criticism and interpretation , Kioko, Ndinda -- Sometime Before Maulidi , Kioko, Ndinda -- Some Freedom Dreams , Authors, Kenyan -- Criticism and interpretation , Kenyan fiction (English) -- History and criticism , Kenyan literature (English) -- History and criticism
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/163168 , vital:41015
- Description: This study investigates the literary activities of two emerging female Kenyan writers, Claudette Okwiri Oduor and Jacqueline Ndinda Kioko, both of whom are award-winning authors. Oduor won the 2014 Caine Prize for African Writing while Kioko bagged the Wasafiri New Writing Fiction Award 2017. It examines specifically how the writers deal with memory and mourning in negotiating between the past and future. I explore how their fictional and non-fictional narratives assist individuals and groups to confront loss, reconstruct new identities, and renegotiate belonging amidst personal and social upheaval. The fictional narratives at the centre of this research are Oduor’s “The Plea Bargain” (2011), “My Father’s Head” (2013) and “Rag Doll” (2014), and Kioko’s “Sometime Before Maulidi” (2014) and “Some Freedom Dreams” (2017). The study explores the themes of mental illness, existential crisis, and fragmentation, and considers bereavement, queer relationships, cultural freedom, and social recognition. The research further considers the active participation of these two writers in Kenya’s contemporary literary-cultural conversations, which span different genres and various media platforms, including blogs, YouTube clips, online magazines, and social media networks in dialogue with other writers. I trace the significance of the literary-cultural link these authors have with their local, continental, and global counterparts in countries like Uganda, Nigeria, and South Africa. The link finds expression through their (in)direct association with some of the new online publishing outlets in Kenya like Jalada Africa, Enkare Review, and Kikwetu. More importantly, their shared participation in and association with such international awards and scholarships as the Commonwealth Short Story Prize, Kwani Trust Manuscript Project, and Miles Morland Foundation is integral in apprehending contemporary literary exchanges and multidirectional flows of publishing in Africa and beyond. I equally illustrate how mentorship of younger writers through local writers’ organisations and collectives like AMKA and Writivism help in the formation of an alternative canon other than the mainstream. The study affirms that the authors seem to transcend the boundaries of production and circulation by fluidly moving between electronic and non-electronic platforms, thus mimicking the memory production of remembering, repeating, and working through.
- Full Text:
- Date Issued: 2020
- Authors: Awuor, Nicholas Amol
- Date: 2020
- Subjects: Oduor, Okwiri -- Criticism and interpretation , Oduor, Okwiri -- The plea bargain , Oduor, Okwiri -- My father's head , Oduor, Okwiri -- Rag doll , Kioko, Ndinda -- Criticism and interpretation , Kioko, Ndinda -- Sometime Before Maulidi , Kioko, Ndinda -- Some Freedom Dreams , Authors, Kenyan -- Criticism and interpretation , Kenyan fiction (English) -- History and criticism , Kenyan literature (English) -- History and criticism
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/163168 , vital:41015
- Description: This study investigates the literary activities of two emerging female Kenyan writers, Claudette Okwiri Oduor and Jacqueline Ndinda Kioko, both of whom are award-winning authors. Oduor won the 2014 Caine Prize for African Writing while Kioko bagged the Wasafiri New Writing Fiction Award 2017. It examines specifically how the writers deal with memory and mourning in negotiating between the past and future. I explore how their fictional and non-fictional narratives assist individuals and groups to confront loss, reconstruct new identities, and renegotiate belonging amidst personal and social upheaval. The fictional narratives at the centre of this research are Oduor’s “The Plea Bargain” (2011), “My Father’s Head” (2013) and “Rag Doll” (2014), and Kioko’s “Sometime Before Maulidi” (2014) and “Some Freedom Dreams” (2017). The study explores the themes of mental illness, existential crisis, and fragmentation, and considers bereavement, queer relationships, cultural freedom, and social recognition. The research further considers the active participation of these two writers in Kenya’s contemporary literary-cultural conversations, which span different genres and various media platforms, including blogs, YouTube clips, online magazines, and social media networks in dialogue with other writers. I trace the significance of the literary-cultural link these authors have with their local, continental, and global counterparts in countries like Uganda, Nigeria, and South Africa. The link finds expression through their (in)direct association with some of the new online publishing outlets in Kenya like Jalada Africa, Enkare Review, and Kikwetu. More importantly, their shared participation in and association with such international awards and scholarships as the Commonwealth Short Story Prize, Kwani Trust Manuscript Project, and Miles Morland Foundation is integral in apprehending contemporary literary exchanges and multidirectional flows of publishing in Africa and beyond. I equally illustrate how mentorship of younger writers through local writers’ organisations and collectives like AMKA and Writivism help in the formation of an alternative canon other than the mainstream. The study affirms that the authors seem to transcend the boundaries of production and circulation by fluidly moving between electronic and non-electronic platforms, thus mimicking the memory production of remembering, repeating, and working through.
- Full Text:
- Date Issued: 2020
Between past and future: memory and mourning in the stories of Okwiri Oduor and Ndinda Kioko
- Authors: Awuor, Nicholas Amol
- Date: 2020
- Subjects: Women authors, Kenyan , Oduor, Okwiri -- The plea bargain , Oduor, Okwiri -- My father's head , Oduor, Okwiri -- Rag doll , Kioko, Ndinda -- Sometime before Maulidi , Kioko, Ndinda -- Some freedom dreams , Women and literature -- Africa , Bereavement -- Fiction , Culture in literature , Liberty in literature
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/161229 , vital:40608
- Description: This study investigates the literary activities of two emerging female Kenyan writers, Claudette Okwiri Oduor and Jacqueline Ndinda Kioko, both of whom are award-winning authors. Oduor won the 2014 Caine Prize for African Writing while Kioko bagged the Wasafiri New Writing Fiction Award 2017. It examines specifically how the writers deal with memory and mourning in negotiating between the past and future. I explore how their fictional and non-fictional narratives assist individuals and groups to confront loss, reconstruct new identities, and renegotiate belonging amidst personal and social upheaval. The fictional narratives at the centre of this research are Oduor’s “The Plea Bargain” (2011), “My Father’s Head” (2013) and “Rag Doll” (2014), and Kioko’s “Sometime Before Maulidi” (2014) and “Some Freedom Dreams” (2017). The study explores the themes of mental illness, existential crisis, and fragmentation, and considers bereavement, queer relationships, cultural freedom, and social recognition. The research further considers the active participation of these two writers in Kenya’s contemporary literary-cultural conversations, which span different genres and various media platforms, including blogs, YouTube clips, online magazines, and social media networks in dialogue with other writers. . I trace the significance of the literary-cultural link these authors have with their local, continental, and global counterparts in countries like Uganda, Nigeria, and South Africa. The link finds expression through their (in)direct association with some of the new online publishing outlets in Kenya like Jalada Africa, Enkare Review, and Kikwetu. More importantly, their shared participation in and association with such international awards and scholarships as the Commonwealth Short Story Prize, Kwani Trust Manuscript Project, and Miles Morland Foundation is integral in apprehending contemporary literary exchanges and multidirectional flows of publishing in Africa and beyond. I equally illustrate how mentorship of younger writers through local writers’ organisations and collectives like AMKA and Writivism help in the formation of an alternative canon other than the mainstream. The study affirms that the authors seem to transcend the boundaries of production and circulation by fluidly moving between electronic and non-electronic platforms, thus mimicking the memory production of remembering, repeating, and working through.
- Full Text:
- Date Issued: 2020
- Authors: Awuor, Nicholas Amol
- Date: 2020
- Subjects: Women authors, Kenyan , Oduor, Okwiri -- The plea bargain , Oduor, Okwiri -- My father's head , Oduor, Okwiri -- Rag doll , Kioko, Ndinda -- Sometime before Maulidi , Kioko, Ndinda -- Some freedom dreams , Women and literature -- Africa , Bereavement -- Fiction , Culture in literature , Liberty in literature
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/161229 , vital:40608
- Description: This study investigates the literary activities of two emerging female Kenyan writers, Claudette Okwiri Oduor and Jacqueline Ndinda Kioko, both of whom are award-winning authors. Oduor won the 2014 Caine Prize for African Writing while Kioko bagged the Wasafiri New Writing Fiction Award 2017. It examines specifically how the writers deal with memory and mourning in negotiating between the past and future. I explore how their fictional and non-fictional narratives assist individuals and groups to confront loss, reconstruct new identities, and renegotiate belonging amidst personal and social upheaval. The fictional narratives at the centre of this research are Oduor’s “The Plea Bargain” (2011), “My Father’s Head” (2013) and “Rag Doll” (2014), and Kioko’s “Sometime Before Maulidi” (2014) and “Some Freedom Dreams” (2017). The study explores the themes of mental illness, existential crisis, and fragmentation, and considers bereavement, queer relationships, cultural freedom, and social recognition. The research further considers the active participation of these two writers in Kenya’s contemporary literary-cultural conversations, which span different genres and various media platforms, including blogs, YouTube clips, online magazines, and social media networks in dialogue with other writers. . I trace the significance of the literary-cultural link these authors have with their local, continental, and global counterparts in countries like Uganda, Nigeria, and South Africa. The link finds expression through their (in)direct association with some of the new online publishing outlets in Kenya like Jalada Africa, Enkare Review, and Kikwetu. More importantly, their shared participation in and association with such international awards and scholarships as the Commonwealth Short Story Prize, Kwani Trust Manuscript Project, and Miles Morland Foundation is integral in apprehending contemporary literary exchanges and multidirectional flows of publishing in Africa and beyond. I equally illustrate how mentorship of younger writers through local writers’ organisations and collectives like AMKA and Writivism help in the formation of an alternative canon other than the mainstream. The study affirms that the authors seem to transcend the boundaries of production and circulation by fluidly moving between electronic and non-electronic platforms, thus mimicking the memory production of remembering, repeating, and working through.
- Full Text:
- Date Issued: 2020
A contribution to a generic revision of Simochromis and Tropheus (Pisces : Cichlidae) - from Lake Tanganyika, with special reference to the Pharyngeal Apophysis and its taxonomic importance
- Authors: Axelrod, Glen S
- Date: 1978
- Subjects: Cichlids -- Tanganyika, Lake
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5349 , http://hdl.handle.net/10962/d1007510 , Cichlids -- Tanganyika, Lake
- Description: The purpose of this thesis is to investigate the taxonomic status of Simochromis and Tropheue. Material for the study wae collected during three visits to Lake Tanganyika in 1976-1977. Tropheus polli G. S . Axelrod 1977, was found and described, and a new species of Simochromis was found and will be described in a forthcoming paper. Nine colour varieties of Tropheus maorii and three colour varieties of Tropheus duboisi were found and described. A diagnosis and description, with colour photographs, is given using morphometries and meristics of the five species of Simochromis and four species of Tropheus. A dissection and cleaning technique tor the pharyngeal apophysis and lower pharyngeal bone is explained, together with a method for the interpretation of relative bone composition of the pharyngeal apophysis. Photographs are included. The dentition is examined, evaluated and figured. Doubt has been cast upon the taxonomic validity of the composition of the pharyngeal apophysis as an indicator of affinity at the sub familial level. This is shown by its seeming lack of functional relationship, apparent arbitrary variation, interspecific variability in Simochromis and Tropheus, and intraspecific variability in S. diagramma and T. duboisi. Thus, the apophysis cannot be considered a reliable cichlid taxonomic characteristic at any level of classification, unless its validity is Substantiated in each instance. Furthermore, it is considered very probable that the Tropheus-Simochromis species complex is a monophyletic assemblage at the genus level, on the basis of similar dentition and mouth form, which is unique in Lake Tanganyika. It is proposed on phyletic grounds that Simochromis and Tropheus be united into the one genus Tropheus, and that Tropheus be divided into the subgenera , Tropheus (Tropheus) and Tropheus (Simochromis), along the lines of its previous division in two separate genera. Characteristics supporting this division include differences in the anal and dorsal fin meristic counts noted in the original descriptions of the genera. In addition, two modifications of the dentition were found during the course of this study which are not mentioned in any previous literature. It is considered probable, that Tropheus (Tropheus) and Tropheus (Simochromis) are monophyletic sister groups within the Tropheus complex. Pseudosimochromis Nelissen 1977 is not considered to be a taxonomically valid genus on either phyletic or gradistic grounds, and is included within Tropheus (Simochromis). The lower pharyngeal bone of T . (S.) diagramma is considered to be plesiomorphic in tooth arrangement, size and shape. A preliminary worKing hypothesis is established on the basis of the conjectures made and other available information which supports the phyletic relationship suggested by Fryer and lIes (1972). An illustration is given.
- Full Text:
- Date Issued: 1978
- Authors: Axelrod, Glen S
- Date: 1978
- Subjects: Cichlids -- Tanganyika, Lake
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5349 , http://hdl.handle.net/10962/d1007510 , Cichlids -- Tanganyika, Lake
- Description: The purpose of this thesis is to investigate the taxonomic status of Simochromis and Tropheue. Material for the study wae collected during three visits to Lake Tanganyika in 1976-1977. Tropheus polli G. S . Axelrod 1977, was found and described, and a new species of Simochromis was found and will be described in a forthcoming paper. Nine colour varieties of Tropheus maorii and three colour varieties of Tropheus duboisi were found and described. A diagnosis and description, with colour photographs, is given using morphometries and meristics of the five species of Simochromis and four species of Tropheus. A dissection and cleaning technique tor the pharyngeal apophysis and lower pharyngeal bone is explained, together with a method for the interpretation of relative bone composition of the pharyngeal apophysis. Photographs are included. The dentition is examined, evaluated and figured. Doubt has been cast upon the taxonomic validity of the composition of the pharyngeal apophysis as an indicator of affinity at the sub familial level. This is shown by its seeming lack of functional relationship, apparent arbitrary variation, interspecific variability in Simochromis and Tropheus, and intraspecific variability in S. diagramma and T. duboisi. Thus, the apophysis cannot be considered a reliable cichlid taxonomic characteristic at any level of classification, unless its validity is Substantiated in each instance. Furthermore, it is considered very probable that the Tropheus-Simochromis species complex is a monophyletic assemblage at the genus level, on the basis of similar dentition and mouth form, which is unique in Lake Tanganyika. It is proposed on phyletic grounds that Simochromis and Tropheus be united into the one genus Tropheus, and that Tropheus be divided into the subgenera , Tropheus (Tropheus) and Tropheus (Simochromis), along the lines of its previous division in two separate genera. Characteristics supporting this division include differences in the anal and dorsal fin meristic counts noted in the original descriptions of the genera. In addition, two modifications of the dentition were found during the course of this study which are not mentioned in any previous literature. It is considered probable, that Tropheus (Tropheus) and Tropheus (Simochromis) are monophyletic sister groups within the Tropheus complex. Pseudosimochromis Nelissen 1977 is not considered to be a taxonomically valid genus on either phyletic or gradistic grounds, and is included within Tropheus (Simochromis). The lower pharyngeal bone of T . (S.) diagramma is considered to be plesiomorphic in tooth arrangement, size and shape. A preliminary worKing hypothesis is established on the basis of the conjectures made and other available information which supports the phyletic relationship suggested by Fryer and lIes (1972). An illustration is given.
- Full Text:
- Date Issued: 1978
Mannich base metal complexes and their thiocyanate analogues as catalysts in the oxidation of Catechol
- Authors: Ayeni, Ayowole Olaolu
- Date: 2018
- Subjects: Mannich bases , Catechol , Catechol -- Oxidation , Thiocyanates , Catalysts
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/62339 , vital:28156
- Description: The study focused on the design of new Cu(II) and Fe(III) complexes, with or without thiocyanate (NCS-), as possible candidates of catechol oxidation using 3,5-di-tert-butyl catechol (3,5-DTBC) as substrate. Two classes of Mannich bases were studied depending on the active methylene group from which they were formed, being either p-cresol or acetaminophen. The ligands were characterised by 1H and 13C NMR spectroscopy. Crystal structures of three of the ligands are newly reported, along with detailed discussion of polymorphism observed in one of the ligands, and the nature of the hydrogen within the ligands in the solid state as well as in solution. The Mannich bases behaved as bidentate (NO), tridentate (NNO) and tetradentate (NNOO) ligands on coordination to Cu(II) and Fe(III) ions in which the hydroxyl group may be protonated or deprotonated. Coordination was determined by IR spectroscopy, investigating shifts in vOH, vC-O and in vCNC of the Mannich bases. The vCNC stretching frequencies v1 and v2 of asymmetrical piperazine Mannich bases were observed to shift upward in few cases upon complexation and this is attributed to (chair-boat) conformational change. The mode of coordination of the thiocyanate was determined by IR spectroscopy. Of the forty metal complexes investigated, six groups of metal complexes were identified as follows: (i) Ma(Ln)aClb-cH2O; (ii) Ma(HLn)a(NCS)aClb; (iii) Ma(Ln)a(NCS)aClb; (iv) Ma(HLn)aClb-cH2O; (v) Ma(Ln)a(NCS)a-cH2O; (vi) Ma(HLn)a(NCS)a-cH2O where a = 1 - 2 ; b = 1 - 4, c = 1 - 8. Molar conductivity values of 4.38 - 161.77 Q-1.cm2.mol-1 for the Cu(II) and Fe(III) complexes in DMSO showed that they range from non-electrolytes to 1:1 and 1:2 electrolytes. Electronic spectra for the ligands and the complexes were conducted in DMF and DMSO. The ligands are characterised by and n→n* and n→n* transitions. Intraligand charge transfer transitions peculiar to the nitro group were observed at about 430 nm for the nitro containing ligands. On coordination, these bands overshadowed the d-d transitions particularly for the nitro-Mannich bases. On complexation, ligand to metal charge transfer transitions associated with the hydroxyl were observed between 320 - 420 nm. Charge transfer transitions associated with the thiocyanates were also observed and discussed. The d-d transitions for high spin Fe(III) complexes are spin forbidden and generally uninformative. Those of Cu(II) are spin allowed and allow tentative structural proposals. Square planar and octahedral geometry are generally prevalent in the Cu(II) complexes with trigonal bipyramidal observed in few instances. The Fe(III) complexes are generally octahedral. Thirty-nine of the forty synthesised Cu(II) and Fe(III) complexes were catalytically active on the substrate (3,5-DTBC) in DMF with turnover rates (kcat) reported in the range of 1.86 ± 0.09 to 112.32 ± 3.72 h-1. From this pool of complexes, sixteen isostructural pairs were identified in terms of geometry, molecular formula and the source of the Mannich base and the following conclusions were made: The presence of thiocyanate in the metal complexes reduce catecholase activity; the Cu(II) complexes generally have better activity but the Fe(III) complexes become more relatively active with highly electron donating groups while the Cu(II) complexes become less; dinuclear complexes have greater activity than the mononuclear.
- Full Text:
- Date Issued: 2018
- Authors: Ayeni, Ayowole Olaolu
- Date: 2018
- Subjects: Mannich bases , Catechol , Catechol -- Oxidation , Thiocyanates , Catalysts
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/62339 , vital:28156
- Description: The study focused on the design of new Cu(II) and Fe(III) complexes, with or without thiocyanate (NCS-), as possible candidates of catechol oxidation using 3,5-di-tert-butyl catechol (3,5-DTBC) as substrate. Two classes of Mannich bases were studied depending on the active methylene group from which they were formed, being either p-cresol or acetaminophen. The ligands were characterised by 1H and 13C NMR spectroscopy. Crystal structures of three of the ligands are newly reported, along with detailed discussion of polymorphism observed in one of the ligands, and the nature of the hydrogen within the ligands in the solid state as well as in solution. The Mannich bases behaved as bidentate (NO), tridentate (NNO) and tetradentate (NNOO) ligands on coordination to Cu(II) and Fe(III) ions in which the hydroxyl group may be protonated or deprotonated. Coordination was determined by IR spectroscopy, investigating shifts in vOH, vC-O and in vCNC of the Mannich bases. The vCNC stretching frequencies v1 and v2 of asymmetrical piperazine Mannich bases were observed to shift upward in few cases upon complexation and this is attributed to (chair-boat) conformational change. The mode of coordination of the thiocyanate was determined by IR spectroscopy. Of the forty metal complexes investigated, six groups of metal complexes were identified as follows: (i) Ma(Ln)aClb-cH2O; (ii) Ma(HLn)a(NCS)aClb; (iii) Ma(Ln)a(NCS)aClb; (iv) Ma(HLn)aClb-cH2O; (v) Ma(Ln)a(NCS)a-cH2O; (vi) Ma(HLn)a(NCS)a-cH2O where a = 1 - 2 ; b = 1 - 4, c = 1 - 8. Molar conductivity values of 4.38 - 161.77 Q-1.cm2.mol-1 for the Cu(II) and Fe(III) complexes in DMSO showed that they range from non-electrolytes to 1:1 and 1:2 electrolytes. Electronic spectra for the ligands and the complexes were conducted in DMF and DMSO. The ligands are characterised by and n→n* and n→n* transitions. Intraligand charge transfer transitions peculiar to the nitro group were observed at about 430 nm for the nitro containing ligands. On coordination, these bands overshadowed the d-d transitions particularly for the nitro-Mannich bases. On complexation, ligand to metal charge transfer transitions associated with the hydroxyl were observed between 320 - 420 nm. Charge transfer transitions associated with the thiocyanates were also observed and discussed. The d-d transitions for high spin Fe(III) complexes are spin forbidden and generally uninformative. Those of Cu(II) are spin allowed and allow tentative structural proposals. Square planar and octahedral geometry are generally prevalent in the Cu(II) complexes with trigonal bipyramidal observed in few instances. The Fe(III) complexes are generally octahedral. Thirty-nine of the forty synthesised Cu(II) and Fe(III) complexes were catalytically active on the substrate (3,5-DTBC) in DMF with turnover rates (kcat) reported in the range of 1.86 ± 0.09 to 112.32 ± 3.72 h-1. From this pool of complexes, sixteen isostructural pairs were identified in terms of geometry, molecular formula and the source of the Mannich base and the following conclusions were made: The presence of thiocyanate in the metal complexes reduce catecholase activity; the Cu(II) complexes generally have better activity but the Fe(III) complexes become more relatively active with highly electron donating groups while the Cu(II) complexes become less; dinuclear complexes have greater activity than the mononuclear.
- Full Text:
- Date Issued: 2018
Africa's golden age debunked: a study of the sources of select black African historical novels
- Ayivor, Moses Geoffrey Kwame
- Authors: Ayivor, Moses Geoffrey Kwame
- Date: 1994
- Subjects: Mofolo, Thomas, 1875?-1948 -- Criticism and interpretation , Plaatje, Sol. T. (Solomon Tshekisho), 1876-1932 , Armah, Ayi Kwei, 1939 -- Criticism and interpretation , Ouologuem, Yambo, 1940- , African literature -- 20th century -- History and criticism , African literature -- Black authors -- History and criticism
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2232 , http://hdl.handle.net/10962/d1002275 , Mofolo, Thomas, 1875?-1948 -- Criticism and interpretation , Plaatje, Sol. T. (Solomon Tshekisho), 1876-1932 , Armah, Ayi Kwei, 1939 -- Criticism and interpretation , Ouologuem, Yambo, 1940- , African literature -- 20th century -- History and criticism , African literature -- Black authors -- History and criticism
- Description: The main thesis of this dissertation is that even a casual analysis of African writing reveals that contemporary African literature has and is still undergoing a distinctive metamorphosis. This change, which amounts to a significant departure from the early fifties, derives its creative impulse from demonic anger and cynical iconoclasm and is triggered by the mind-shattering disillusion that followed independence. The proclivity towards tyranny and the exploitation of the ruled in modern Africa is traced by radical African creative writers to an ancient source: the legendary and god-like rulers of precolonial Africa. Ouologuem's Bound to Violence and Armah's Two Thousand Seasons and The Healers hypothesize that past sins begot present sins. The legendary warrior heroes of the past, whose glory and splendour were once exalted in African writing, are now ruthlessly disentombed and paraded as miscreants and despots, who not only brutalized and sold their people into slavery but also ideologically fabricated their own legends and myths in order to maximize their tyrannical power. The preoccupation of these works is, therefore, to divest the ancient heroes of their false glory. contemporary critics tend to perceive this anti-traditional posture purely as a modern trend in African literature. The truth of the matter, however, is that the literary foundations of this anti-nativist/anti-Afrocentric literary tradition were laid by Thomas Mofolo and Sol Plaatje, whose Chaka (1925) and Mhudi (1930) are the precursors. The five primary works in this study parody and veer away from the generally accepted traditional African epic heroism and recorded history towards a communal heroic ideal which celebrates the larger community instead of the single epic heroes normally romanticized in African legendary tradition. These novelists, while dismantling the European and African myths about Africa's Golden Age, also disfigure the often glorified ancient historical landmarks and the fabled heroes of Africa's oral and recorded history. The rationale behind this investigation is the fact that though these works have innovated, assimilated, and parodied the African oral arts, particularly traditional African epic heroism, no detailed study has been made to explore the literary transformation these texts have undergone as written works. Treating African texts only as appendages of Western literature may undermine the ability of the critical evaluations which go into the heart of these texts and unravel their deeper meanings. The outcome of this kind of approach is that pertinent issues of style and theme originating from negro-African metaphysics, oral traditions, and iconography could thereby be left unexplored. Besides, the bulk of the current body of criticism on African literature, particularly on colonial Africa, tends to concentrate on colonialist Christian values and Western literary production models. One of the overriding concerns of this research, therefore, is to veer away from merely rehashing Eurocentric pronouncements on European influences and literary modes parodied by these works, by taking a fresh. look at the texts from the perspective of Afrocentrism and in particular from the point of view of the traditional African oral bards. To this end, therefore, the dissertation is divided into six main chapters and a short concluding chapter: Chapter 1, A Survey of Black Representations of Pre-colonial Africa, functions as an introduction, sketches the European image versus the Black counter-discourse, and locates the study within the current debate on the concept of pre-colonial Africa's Golden Age. Chapter 2, Thomas Mofolo's "Inverted Epic Hero", the nucleus of the study I analyzes the anti-epic and ironic modes manipulated by the text and also maps out the epic generic framework which structures the whole dissertation. Chapter 3, Traditional African Epic Heroism Revised, discusses Plaatje's Mhudi, paying special attention to the text's deployment of the African epic genre as well as the caricaturist and the anti-heroic modes. In Chapter 4, Yambo Ouologuem's Bound to Violence is examined under the title A World Trapped in an Orgy of Violence, Barbarism and Servitude. African oral art is used as the hermeneutic key in unlocking the complexities of Ouologuem's novel. Chapter 5, The African Anti-Legendary Creative Mythology, scrutinizes Armah's Two Thousand Seasons, highlighting, among other topics, Armah's daring innovative stylistic experimentation. Chapter 6, entitled The Akan Iconic Forest of Symbols, deals with Armah' s The Healers, concentrating on the Akan iconographic backdrop which shapes and informs this work. And finally, The Metamorphosis of Traditional African Epic Heroism, the title of the concluding chapter, sums up this dissertation.
- Full Text:
- Date Issued: 1994
- Authors: Ayivor, Moses Geoffrey Kwame
- Date: 1994
- Subjects: Mofolo, Thomas, 1875?-1948 -- Criticism and interpretation , Plaatje, Sol. T. (Solomon Tshekisho), 1876-1932 , Armah, Ayi Kwei, 1939 -- Criticism and interpretation , Ouologuem, Yambo, 1940- , African literature -- 20th century -- History and criticism , African literature -- Black authors -- History and criticism
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2232 , http://hdl.handle.net/10962/d1002275 , Mofolo, Thomas, 1875?-1948 -- Criticism and interpretation , Plaatje, Sol. T. (Solomon Tshekisho), 1876-1932 , Armah, Ayi Kwei, 1939 -- Criticism and interpretation , Ouologuem, Yambo, 1940- , African literature -- 20th century -- History and criticism , African literature -- Black authors -- History and criticism
- Description: The main thesis of this dissertation is that even a casual analysis of African writing reveals that contemporary African literature has and is still undergoing a distinctive metamorphosis. This change, which amounts to a significant departure from the early fifties, derives its creative impulse from demonic anger and cynical iconoclasm and is triggered by the mind-shattering disillusion that followed independence. The proclivity towards tyranny and the exploitation of the ruled in modern Africa is traced by radical African creative writers to an ancient source: the legendary and god-like rulers of precolonial Africa. Ouologuem's Bound to Violence and Armah's Two Thousand Seasons and The Healers hypothesize that past sins begot present sins. The legendary warrior heroes of the past, whose glory and splendour were once exalted in African writing, are now ruthlessly disentombed and paraded as miscreants and despots, who not only brutalized and sold their people into slavery but also ideologically fabricated their own legends and myths in order to maximize their tyrannical power. The preoccupation of these works is, therefore, to divest the ancient heroes of their false glory. contemporary critics tend to perceive this anti-traditional posture purely as a modern trend in African literature. The truth of the matter, however, is that the literary foundations of this anti-nativist/anti-Afrocentric literary tradition were laid by Thomas Mofolo and Sol Plaatje, whose Chaka (1925) and Mhudi (1930) are the precursors. The five primary works in this study parody and veer away from the generally accepted traditional African epic heroism and recorded history towards a communal heroic ideal which celebrates the larger community instead of the single epic heroes normally romanticized in African legendary tradition. These novelists, while dismantling the European and African myths about Africa's Golden Age, also disfigure the often glorified ancient historical landmarks and the fabled heroes of Africa's oral and recorded history. The rationale behind this investigation is the fact that though these works have innovated, assimilated, and parodied the African oral arts, particularly traditional African epic heroism, no detailed study has been made to explore the literary transformation these texts have undergone as written works. Treating African texts only as appendages of Western literature may undermine the ability of the critical evaluations which go into the heart of these texts and unravel their deeper meanings. The outcome of this kind of approach is that pertinent issues of style and theme originating from negro-African metaphysics, oral traditions, and iconography could thereby be left unexplored. Besides, the bulk of the current body of criticism on African literature, particularly on colonial Africa, tends to concentrate on colonialist Christian values and Western literary production models. One of the overriding concerns of this research, therefore, is to veer away from merely rehashing Eurocentric pronouncements on European influences and literary modes parodied by these works, by taking a fresh. look at the texts from the perspective of Afrocentrism and in particular from the point of view of the traditional African oral bards. To this end, therefore, the dissertation is divided into six main chapters and a short concluding chapter: Chapter 1, A Survey of Black Representations of Pre-colonial Africa, functions as an introduction, sketches the European image versus the Black counter-discourse, and locates the study within the current debate on the concept of pre-colonial Africa's Golden Age. Chapter 2, Thomas Mofolo's "Inverted Epic Hero", the nucleus of the study I analyzes the anti-epic and ironic modes manipulated by the text and also maps out the epic generic framework which structures the whole dissertation. Chapter 3, Traditional African Epic Heroism Revised, discusses Plaatje's Mhudi, paying special attention to the text's deployment of the African epic genre as well as the caricaturist and the anti-heroic modes. In Chapter 4, Yambo Ouologuem's Bound to Violence is examined under the title A World Trapped in an Orgy of Violence, Barbarism and Servitude. African oral art is used as the hermeneutic key in unlocking the complexities of Ouologuem's novel. Chapter 5, The African Anti-Legendary Creative Mythology, scrutinizes Armah's Two Thousand Seasons, highlighting, among other topics, Armah's daring innovative stylistic experimentation. Chapter 6, entitled The Akan Iconic Forest of Symbols, deals with Armah' s The Healers, concentrating on the Akan iconographic backdrop which shapes and informs this work. And finally, The Metamorphosis of Traditional African Epic Heroism, the title of the concluding chapter, sums up this dissertation.
- Full Text:
- Date Issued: 1994
An in vitro investigation of novel quinolone derivatives on selected pharmacological targets for diabetes mellitus and associated complications
- Authors: Ayodele, Omobolanle Opeyemi
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/409813 , vital:70632
- Description: Diabetes mellitus (DM) is a group of endocrine and metabolic disorders characterised and identified by the presence of hyperglycaemia over a long period and, to an extent, accompanied by hyperlipidaemia. CVD has been reported to be the leading cause of mortality in patients with DM. Several antidiabetic agents are available for managing DM, but these agents are not for curative therapy and present with undesirable side effects. In addition, these agents become less effective as the patient's condition progresses to complete beta-cell failure. Therefore, developing newer antidiabetic agents with minimal undesirable side effects, prolonged efficacy and protection against the development of DM complications are necessary. This study was conducted to identify potential novel antidiabetic agents with cardiovascular-protective activity. The compounds of interest for the study were quinolone derivatives since quinolones have been reported to have an antihyperglycaemic effect. , Thesis (MSc) -- Faculty of Pharmacy, 2023
- Full Text:
- Date Issued: 2023-03-29
- Authors: Ayodele, Omobolanle Opeyemi
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/409813 , vital:70632
- Description: Diabetes mellitus (DM) is a group of endocrine and metabolic disorders characterised and identified by the presence of hyperglycaemia over a long period and, to an extent, accompanied by hyperlipidaemia. CVD has been reported to be the leading cause of mortality in patients with DM. Several antidiabetic agents are available for managing DM, but these agents are not for curative therapy and present with undesirable side effects. In addition, these agents become less effective as the patient's condition progresses to complete beta-cell failure. Therefore, developing newer antidiabetic agents with minimal undesirable side effects, prolonged efficacy and protection against the development of DM complications are necessary. This study was conducted to identify potential novel antidiabetic agents with cardiovascular-protective activity. The compounds of interest for the study were quinolone derivatives since quinolones have been reported to have an antihyperglycaemic effect. , Thesis (MSc) -- Faculty of Pharmacy, 2023
- Full Text:
- Date Issued: 2023-03-29