https://commons.ru.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://commons.ru.ac.za/vital/access/manager/Repository/vital:3812 Wed 12 May 2021 19:28:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28591 Wed 12 May 2021 19:06:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28594 Wed 12 May 2021 19:05:02 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:4562 Co(II) > Ni(II). The Schiff-base derivatives were prepared from the ligands and para-methoxysalicylaldehyde and their Cu(II) complexes were synthesized in order to determine their biological activity. The Schiff-base ligands were found to be less active than their parent ligands. The Cu(II) complexes are not soluble in water, DMSO or DMF, as a result and could not be evaluated for their biological activity. Based on the good results from the antimicrobial evaluation, the antiplasmodial activity of some of the Co(II), Ni(II) and Cu(II) complexes of the thiomethylated ligands against Plasmodium falciparum (FCR-3) was determined. At 50 μM concentration level, the Cu(II) complexes show activity equal or better than the prophylactic chloroquine. The Cu(II) complexes with the methoxy-substituted demonstrated exceptional activity but their Co(II) and Ni(II) analogues did not show any activity. The cytotoxicity of the active Cu(II) complexes at 50 μM concentration was determined against the breast cancer cell line (MDA-MB-231). The compounds destroyed the cancer cell in the range of 28–40%, thus showing their preferred activity against the parasitic cell instead of the cancer cell. The selectivity demonstrated by these compounds have shown them to be potential antimalarial agents and this could be further investigated.]]> Wed 12 May 2021 17:24:20 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:3862 Wed 12 May 2021 16:47:29 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:3733 Thu 13 May 2021 12:37:24 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:4560 Thu 13 May 2021 08:53:23 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28538 Thu 13 May 2021 07:11:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:3839 Thu 13 May 2021 06:47:49 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:3739 Thu 13 May 2021 04:41:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28592 Thu 13 May 2021 03:43:13 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:3871 Thu 13 May 2021 03:06:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:3861 Thu 13 May 2021 01:38:35 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28593 Thu 13 May 2021 00:58:01 SAST ]]>