https://commons.ru.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://commons.ru.ac.za/vital/access/manager/Repository/vital:28690 Wed 19 Apr 2023 13:28:11 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:29198 Wed 15 Mar 2023 15:47:55 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28087 Wed 15 Mar 2023 09:37:04 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41156 Wed 12 May 2021 14:04:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41124 Wed 01 Dec 2021 08:13:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41018 Tue 30 Nov 2021 08:34:14 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45415 Tue 25 Apr 2023 09:58:18 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:20319 Thu 16 Mar 2023 12:59:53 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:27485 Thu 13 Apr 2023 12:46:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65775 100 kDa through ultracentrifugation. Mass spectrometry also detected the most abundant peak for all fucoidans to be around 700 Da (m/z). Extracted fucoidans inhibited the activity of α-glucosidase more strongly than the commercial anti-diabetic agent acarbose but were inactive on α-amylase. Fucoidans were also shown to be mixed inhibitors of α-glucosidase. Compellingly, fucoidans synergistically inhibited α-glucosidase in combination with the anti-diabetic agent acarbose, highlighting prospects for combination therapy. Finally, fucoidans demonstrated some anti-proliferative characteristics on HCT116 cancer cells by inhibiting their ability to adhere to the tissue culture plate matrix. Furthermore, some fucoidan extracts inhibited the migration of HCT116 cancer cells from 3D spheroids. Some of our fucoidan extracts also inhibited HCT116 colony formation, demonstrating inhibition of long-term cell survival. The E. maxima water extract also inhibited glucose uptake by HCT116 cells, thereby influencing the glycolytic flux. In conclusion, biologically active fucoidans were successfully extracted from South African brown seaweeds. These fucoidans demonstrated anti-diabetic and anti-cancer properties, revealing their relevance as potential drugs for these diseases.]]> Thu 11 Jan 2024 18:08:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45409 Mon 24 Apr 2023 15:12:54 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45410 Mon 24 Apr 2023 11:43:19 SAST ]]>