https://commons.ru.ac.za/vital/access/manager/Index en-us 5 A new indole alkaloid and other constituents from Monodora minor and Uvaria tanzaniae: their antitrypanosomal and antiplasmodial evaluation https://commons.ru.ac.za/vital/access/manager/Repository/vital:72603 Wed 22 May 2024 03:43:40 SAST ]]> Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa https://commons.ru.ac.za/vital/access/manager/Repository/vital:72606 Wed 22 May 2024 03:41:00 SAST ]]> Biological activities of plant extracts from Ficus elastica and Selaginella vogelli: an antimalarial, antitrypanosomal and cytotoxity evaluation https://commons.ru.ac.za/vital/access/manager/Repository/vital:35853 Wed 15 May 2024 15:53:09 SAST ]]> Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3-L1: https://commons.ru.ac.za/vital/access/manager/Repository/vital:41181 Wed 15 May 2024 10:40:54 SAST ]]> Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues https://commons.ru.ac.za/vital/access/manager/Repository/vital:74101 Wed 10 Jul 2024 16:13:37 SAST ]]> Synthesis, characterization and biological activity of some Dithiourea Derivatives: https://commons.ru.ac.za/vital/access/manager/Repository/vital:41007 Wed 07 Aug 2024 16:02:19 SAST ]]> A New Synthetic Method for Tetraazatricyclic Derivatives and Evaluation of Their Biological Properties https://commons.ru.ac.za/vital/access/manager/Repository/vital:35413 Wed 07 Aug 2024 16:02:18 SAST ]]> Supplementary Material Synthesis and biological evaluation of (E)-cinnamic acid,(E)-2-styrylthiazole and (E)-2-[2-(naphthalen-1-yl) vinyl] thiazole derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:72803 10 cells/cm. Each experiment normally includes a blank control, containing medium without the cells.28,45 Non-contaminated HeLa cells (6.57 x 105 cells per well) in media were allowed to grow in the incubator under an atmosphere of 5% CO2 at 37 0C for 24 h. To each well was dispensed 200 µL of HeLa culture, containing 6.57 x 105 cells under LabEAir laminar flow hood (Vivid Air, South Africa); 20 µL of resazurin dye (Sigma TOX-8) and test compound (50 µL) were added, which were then incubated in the presence of 5% CO2 at 37 0C for 24 hours in a shaker, to enhance the distribution of the dye. The absorbance of each well was measured with Bio-tek Power Wave X fluorometer (Beijing, China), and increases in fluorescence was monitored at a wavelength of 590 nm, using an excitation wavelength of 560 nm.]]> Tue 09 Jul 2024 10:33:03 SAST ]]> Compounds isolation and biological activities of Piptadeniastrum africanum (hook. f.) Brennan (Fabaceae) roots: https://commons.ru.ac.za/vital/access/manager/Repository/vital:38938 Tue 09 Aug 2022 06:12:33 SAST ]]> Potential repurposing of four FDA approved compounds with antiplasmodial activity identified through proteome scale computational drug discovery and in vitro assay https://commons.ru.ac.za/vital/access/manager/Repository/vital:42830 Tue 09 Aug 2022 05:58:00 SAST ]]> In vitro Anti-trypanosomal activities of indanone-based chalcones: https://commons.ru.ac.za/vital/access/manager/Repository/vital:40169 Tue 07 May 2024 12:38:11 SAST ]]> Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity. https://commons.ru.ac.za/vital/access/manager/Repository/vital:35362 125 μM) was observed. Similarly, these compounds exhibited moderate activity against the human protozoal pathogen Trichomonas vaginalis with no observed effect on common microbiome bacterial species. The cross-species inhibitory activity presents the possibility of these compounds serving as broad-spectrum antibiotics for these prevalent three human pathogens.]]> Tue 07 May 2024 12:34:59 SAST ]]> Indolyl-3-ethanone-α-thioethers: a promising new class of non-toxic antimalarial agents https://commons.ru.ac.za/vital/access/manager/Repository/vital:28920 Tue 07 May 2024 12:34:20 SAST ]]> Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters https://commons.ru.ac.za/vital/access/manager/Repository/vital:35803 Tue 07 May 2024 12:33:57 SAST ]]> Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido)methyl]-2-quinolones as potential HIV-1 integrase inhibitors https://commons.ru.ac.za/vital/access/manager/Repository/vital:28913 Tue 07 May 2024 12:33:27 SAST ]]> Synthesis, in vitro cytotoxicity and trypanocidal evaluation of novel 1, 3, 6-substituted non-fluoroquinolones https://commons.ru.ac.za/vital/access/manager/Repository/vital:35409 Tue 07 May 2024 12:33:05 SAST ]]> Synthesis, antiplasmodial and antitrypanosomal evaluation of a series of novel 2-oxoquinoline-based thiosemicarbazone derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:35407 50 % was often observed. Except for compound 9o, none of the final compounds exhibited cytotoxic effects against HeLa cells at 20 μM.]]> Tue 07 May 2024 12:31:51 SAST ]]> New thiazolidine-2,4-dione derivatives combined with organometallic ferrocene: Synthesis, structure and antiparasitic activity https://commons.ru.ac.za/vital/access/manager/Repository/vital:35382 90% viability of the HeLa cell line screened.]]> Tue 07 May 2024 12:31:21 SAST ]]> In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants: Antrocaryon klaineanum (Anacardiaceae) and Diospyros conocarpa (Ebenaceae) https://commons.ru.ac.za/vital/access/manager/Repository/vital:35908 Tue 07 May 2024 12:30:54 SAST ]]> Biological activity of plant extracts and isolated compounds from Alchornea laxiflora: Anti-HIV, antibacterial and cytotoxicity evaluation https://commons.ru.ac.za/vital/access/manager/Repository/vital:35907 Tue 07 May 2024 12:30:13 SAST ]]> Quinolone-isoniazid hybrids: Synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation https://commons.ru.ac.za/vital/access/manager/Repository/vital:35410 Tue 07 May 2024 12:28:22 SAST ]]> Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic Arylpyrrole-Based Chalcone derivatives: https://commons.ru.ac.za/vital/access/manager/Repository/vital:40096 Tue 07 May 2024 12:26:20 SAST ]]> Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers. https://commons.ru.ac.za/vital/access/manager/Repository/vital:35370 Tue 07 May 2024 12:11:09 SAST ]]> Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors https://commons.ru.ac.za/vital/access/manager/Repository/vital:28929 Tue 07 May 2024 12:03:44 SAST ]]> Ferrocenyl and organic novobiocin derivatives: synthesis and their in vitro biological activity https://commons.ru.ac.za/vital/access/manager/Repository/vital:28914 Tue 07 May 2024 11:50:10 SAST ]]> NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum: https://commons.ru.ac.za/vital/access/manager/Repository/vital:41110 Tue 07 May 2024 11:49:12 SAST ]]> Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers: https://commons.ru.ac.za/vital/access/manager/Repository/vital:41114 Tue 07 May 2024 11:47:49 SAST ]]> Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 and ArfGAP domains using a colorimetric plate-based assay: https://commons.ru.ac.za/vital/access/manager/Repository/vital:41242 Tue 07 May 2024 11:44:11 SAST ]]> Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition. https://commons.ru.ac.za/vital/access/manager/Repository/vital:35359 Tue 07 May 2024 11:27:40 SAST ]]> The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction: https://commons.ru.ac.za/vital/access/manager/Repository/vital:38827 Tue 07 May 2024 11:21:22 SAST ]]> Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1, 3-benzoxazine derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:41240 Tue 07 May 2024 11:20:07 SAST ]]> Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays https://commons.ru.ac.za/vital/access/manager/Repository/vital:35647 Tue 07 May 2024 10:34:28 SAST ]]> Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches: https://commons.ru.ac.za/vital/access/manager/Repository/vital:41001 Tue 07 May 2024 10:31:36 SAST ]]> Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides https://commons.ru.ac.za/vital/access/manager/Repository/vital:45331 Thu 15 Aug 2024 14:52:23 SAST ]]> Synthesis and anti-parasitic activity of N-benzylated phosphoramidate Mg2+-chelating ligands https://commons.ru.ac.za/vital/access/manager/Repository/vital:75025 Thu 15 Aug 2024 14:38:32 SAST ]]> Transformations of manool. Tri-and tetracyclic norditerpenoids with in vitro activity against plasmodium falciparum https://commons.ru.ac.za/vital/access/manager/Repository/vital:74956 Thu 15 Aug 2024 14:27:10 SAST ]]> Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance https://commons.ru.ac.za/vital/access/manager/Repository/vital:72745 Thu 15 Aug 2024 09:09:24 SAST ]]> Antiplasmodial Activity of the n-Hexane Extract from Pleurotus ostreatus (Jacq. ex. Fr) P. Kumm https://commons.ru.ac.za/vital/access/manager/Repository/vital:45516 n-hexane extract (IC50=25.18 μg/mL). It also showed mild cytotoxicity (IC50>100 μg/mL; selectivity index >4) compared to the reference drug emetine (IC50=0.013 μg/mL). The known sterol, ergostan-5,7,22-trien-3-ol, was isolated and characterized from the extract. Conclusion: This study reporting for the first time the antiplasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.]]> Thu 15 Aug 2024 09:09:23 SAST ]]> Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion https://commons.ru.ac.za/vital/access/manager/Repository/vital:72802 Thu 15 Aug 2024 09:09:23 SAST ]]> Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein https://commons.ru.ac.za/vital/access/manager/Repository/vital:72799 Thu 15 Aug 2024 09:09:22 SAST ]]> In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants https://commons.ru.ac.za/vital/access/manager/Repository/vital:45519 Thu 15 Aug 2024 09:09:21 SAST ]]> Plasmodium falciparum Hop (PfHop) interacts with the Hsp70 chaperone in a nucleotide-dependent fashion and exhibits ligand selectivity https://commons.ru.ac.za/vital/access/manager/Repository/vital:72801 Thu 15 Aug 2024 09:09:20 SAST ]]> Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities https://commons.ru.ac.za/vital/access/manager/Repository/vital:45163 Thu 15 Aug 2024 09:02:25 SAST ]]> Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity https://commons.ru.ac.za/vital/access/manager/Repository/vital:72613 Thu 15 Aug 2024 09:02:24 SAST ]]> Plasmodium falciparum Hep1 is required to prevent the self aggregation of PfHsp70-3 https://commons.ru.ac.za/vital/access/manager/Repository/vital:28903 Thu 11 Aug 2022 06:48:12 SAST ]]> In Vitro Studies on Antioxidant and AntiParasitic Activities of Compounds Isolated from Rauvolfia caffra Sond https://commons.ru.ac.za/vital/access/manager/Repository/vital:72305 Fri 10 May 2024 12:48:45 SAST ]]> Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues https://commons.ru.ac.za/vital/access/manager/Repository/vital:74591 Fri 02 Aug 2024 16:30:13 SAST ]]>