https://commons.ru.ac.za/vital/access/manager/Index en-us 5 https://commons.ru.ac.za/vital/access/manager/Repository/vital:72603 Wed 22 May 2024 03:43:40 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72611 5 μM for biogenic phosphate precipitation in paleo-systems. Accordingly, we contest the previously proposed suitability of phosphatic stromatolites as a proxy for high ambient phosphate concentrations in supratidal to shallow ocean settings in earth history.]]> Wed 22 May 2024 03:29:45 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35853 Wed 15 May 2024 15:53:09 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72803 10 cells/cm. Each experiment normally includes a blank control, containing medium without the cells.28,45 Non-contaminated HeLa cells (6.57 x 105 cells per well) in media were allowed to grow in the incubator under an atmosphere of 5% CO2 at 37 0C for 24 h. To each well was dispensed 200 µL of HeLa culture, containing 6.57 x 105 cells under LabEAir laminar flow hood (Vivid Air, South Africa); 20 µL of resazurin dye (Sigma TOX-8) and test compound (50 µL) were added, which were then incubated in the presence of 5% CO2 at 37 0C for 24 hours in a shaker, to enhance the distribution of the dye. The absorbance of each well was measured with Bio-tek Power Wave X fluorometer (Beijing, China), and increases in fluorescence was monitored at a wavelength of 590 nm, using an excitation wavelength of 560 nm.]]> Tue 28 May 2024 14:16:45 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35804 Tue 07 May 2024 12:39:53 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:40169 Tue 07 May 2024 12:38:11 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45324 Tue 07 May 2024 12:37:29 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35362 125 μM) was observed. Similarly, these compounds exhibited moderate activity against the human protozoal pathogen Trichomonas vaginalis with no observed effect on common microbiome bacterial species. The cross-species inhibitory activity presents the possibility of these compounds serving as broad-spectrum antibiotics for these prevalent three human pathogens.]]> Tue 07 May 2024 12:34:59 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28920 Tue 07 May 2024 12:34:20 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35803 Tue 07 May 2024 12:33:57 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28913 Tue 07 May 2024 12:33:27 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35409 Tue 07 May 2024 12:33:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35407 50 % was often observed. Except for compound 9o, none of the final compounds exhibited cytotoxic effects against HeLa cells at 20 μM.]]> Tue 07 May 2024 12:31:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35382 90% viability of the HeLa cell line screened.]]> Tue 07 May 2024 12:31:21 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35908 Tue 07 May 2024 12:30:54 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35907 Tue 07 May 2024 12:30:13 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35413 Tue 07 May 2024 12:28:47 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45519 Tue 07 May 2024 12:28:00 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45516 n-hexane extract (IC50=25.18 μg/mL). It also showed mild cytotoxicity (IC50>100 μg/mL; selectivity index >4) compared to the reference drug emetine (IC50=0.013 μg/mL). The known sterol, ergostan-5,7,22-trien-3-ol, was isolated and characterized from the extract. Conclusion: This study reporting for the first time the antiplasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.]]> Tue 07 May 2024 12:27:04 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:40096 Tue 07 May 2024 12:26:20 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45331 Tue 07 May 2024 12:25:34 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35370 Tue 07 May 2024 12:11:09 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28929 Tue 07 May 2024 12:03:44 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28914 Tue 07 May 2024 11:50:10 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41110 Tue 07 May 2024 11:49:12 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41114 Tue 07 May 2024 11:47:49 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35359 Tue 07 May 2024 11:27:40 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41007 Tue 07 May 2024 10:29:43 SAST ]]>