https://commons.ru.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 DSC screening of potential prochlorperazine-excipient interactions in preformulation studies https://commons.ru.ac.za/vital/access/manager/Repository/vital:44212 Wed 08 May 2024 17:31:23 SAST ]]> A comparative study of the effect of different stabilizers on the critical quality attributes of self-assembling nano co-crystals https://commons.ru.ac.za/vital/access/manager/Repository/vital:43931 Wed 08 May 2024 15:56:39 SAST ]]> Top-Down Synthesis of a Lamivudine-Zidovudine Nano Co-Crystal https://commons.ru.ac.za/vital/access/manager/Repository/vital:43918 Wed 08 May 2024 15:56:19 SAST ]]> Nano Co-Crystal Embedded Stimuli-Responsive Hydrogels: A Potential Approach to Treat HIV/AIDS https://commons.ru.ac.za/vital/access/manager/Repository/vital:43915 Wed 08 May 2024 15:55:59 SAST ]]> The identification of the UV degradants of melatonin and their ability to scavenge free radicals https://commons.ru.ac.za/vital/access/manager/Repository/vital:44198 Tue 14 May 2024 12:23:38 SAST ]]> Melatonin alters the photodegradation of paracetamol https://commons.ru.ac.za/vital/access/manager/Repository/vital:44211 Tue 14 May 2024 12:11:47 SAST ]]> Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin https://commons.ru.ac.za/vital/access/manager/Repository/vital:44210 Tue 14 May 2024 12:11:22 SAST ]]> An investigation into the neuroprotective properties of ibuprofen https://commons.ru.ac.za/vital/access/manager/Repository/vital:44209 Tue 14 May 2024 12:10:24 SAST ]]> The effect of variations in pH and temperature on stability of melatonin in aqueous solution https://commons.ru.ac.za/vital/access/manager/Repository/vital:44207 Tue 14 May 2024 12:10:00 SAST ]]> A sensitive and reliable method for the detection of lipid peroxidation in biological tissues https://commons.ru.ac.za/vital/access/manager/Repository/vital:44208 Tue 14 May 2024 12:09:37 SAST ]]> An assessment of the efficacy of two lysine microencapsulation techniques to determine the quantitative lysine requirement of the South African abalone, Haliotis midae L https://commons.ru.ac.za/vital/access/manager/Repository/vital:44197 0.05). The failure of the crystalline L-lysine to illicit growth and nutritional responses is discussed.]]> Tue 14 May 2024 12:09:09 SAST ]]> Spotlight on research: 50 years of Pharmaceutical Sciences Research Excellence Faculty of Pharmacy Rhodes University https://commons.ru.ac.za/vital/access/manager/Repository/vital:44193 Tue 14 May 2024 12:08:09 SAST ]]> A stability-indicating high performance liquid chromatographic assay for the determination of orlistat in capsules https://commons.ru.ac.za/vital/access/manager/Repository/vital:44195 Tue 14 May 2024 12:07:00 SAST ]]> Development and validation of a stability-indicating method for the quantitation of paclitaxel in pharmaceutical dosage forms https://commons.ru.ac.za/vital/access/manager/Repository/vital:44196 Tue 14 May 2024 12:02:22 SAST ]]> The use of experimental design in the development of an HPLC–ECD method for the analysis of captopril https://commons.ru.ac.za/vital/access/manager/Repository/vital:44163 Tue 14 May 2024 11:59:47 SAST ]]> Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers https://commons.ru.ac.za/vital/access/manager/Repository/vital:44156 Tue 14 May 2024 11:59:25 SAST ]]> Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex https://commons.ru.ac.za/vital/access/manager/Repository/vital:44190 Tue 14 May 2024 11:59:01 SAST ]]> Evaluation of the in vitro differential protein adsorption patterns of didanosine-loaded nanostructured lipid carriers (NLCs) for potential targeting to the brain https://commons.ru.ac.za/vital/access/manager/Repository/vital:44160 Tue 14 May 2024 11:58:13 SAST ]]> The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients https://commons.ru.ac.za/vital/access/manager/Repository/vital:44170 Tue 14 May 2024 11:57:11 SAST ]]> Syntheses, protonation constants and antimicrobial activity of 2-substituted N-alkylimidazole derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:44165 2500 µg mL–1) bacteria and all the compounds were inactive against the yeast (Candida albicans).]]> Tue 14 May 2024 11:56:44 SAST ]]> Forced degradation studies of clobetasol 17‐propionate in methanol, propylene glycol, as bulk drug and cream formulations by RP‐HPLC https://commons.ru.ac.za/vital/access/manager/Repository/vital:44154 Tue 14 May 2024 11:56:10 SAST ]]> HPLC method for simultaneous analysis of ranitidine and metronidazole in dosage forms https://commons.ru.ac.za/vital/access/manager/Repository/vital:44272 Tue 14 May 2024 11:55:37 SAST ]]> Electro‐oxidation of acetaminophen on nickel/poly (o‐aminophenol)/multi‐walled carbon nanotube nanocomposite modified graphite electrode. https://commons.ru.ac.za/vital/access/manager/Repository/vital:44173 Tue 14 May 2024 11:55:13 SAST ]]> Electropolymerized Fluorinated Aniline-Based Fiber for Headspace Solid-Phase Microextraction and Gas Chromatographic Determination of Benzaldehyde in Injectable Pharmaceutical Formulations https://commons.ru.ac.za/vital/access/manager/Repository/vital:44175 Tue 14 May 2024 11:54:39 SAST ]]> Synthesis and characterization of ZnO nanoparticle synthesized by a microwave-assisted combustion method and catalytic activity for the removal of ortho-nitrophenol https://commons.ru.ac.za/vital/access/manager/Repository/vital:44075 Tue 14 May 2024 11:54:16 SAST ]]> Amoxicillin removal from aqueous media using multi-walled carbon nanotubes https://commons.ru.ac.za/vital/access/manager/Repository/vital:44076 Tue 14 May 2024 11:53:48 SAST ]]> Academy of Pharmaceutical Sciences https://commons.ru.ac.za/vital/access/manager/Repository/vital:44270 Tue 14 May 2024 11:52:49 SAST ]]> Quantitation of zolpidem in biological fluids by electro-driven microextraction combined with HPLC-UV analysis https://commons.ru.ac.za/vital/access/manager/Repository/vital:44266 75 within 15 minutes. The effect of carbon nanotubes (as solid nano-sorbents) on the membrane performance and EME efficiency was evaluated. The method was linear over the range of 10-1000 ng/mL for zolpidem (R2 >0.9991) with repeatability (%RSD) between 0.3 % and 7.3 % (n = 3). The limits of detection and quantitation were 3 and 10 ng/mL, respectively. The sensitivity of HPLC-UV for the determination of zolpidem was enhanced by electromembrane extraction. Finally, the method was employed for the quantitation of zolpidem in biological samples with relative recoveries in the range of 60-79 %.]]> Tue 14 May 2024 11:52:00 SAST ]]> Development, manufacture and characterization of niosomes for the delivery for nevirapine https://commons.ru.ac.za/vital/access/manager/Repository/vital:44002 Tue 14 May 2024 11:51:22 SAST ]]> Development and Validation of a Stability-indicating RP-HPLC Method Using Quality by Design for Estimating Captopril https://commons.ru.ac.za/vital/access/manager/Repository/vital:44003 2) for captopril and the internal standard with retention times of 3.1 and 6.2 min, respectively. The experimental data revealed that acetonitrile content in the mobile phase and pH are significant factors that affect the retention time and resolution of captopril. Normal probability plots revealed that the residual and predicted data fall approximately on a straight line, indicating that the experimental error for these studies was evenly distributed suggesting that the model could be used to navigate the design space. This approach is useful to expedite method development and optimization activities in analytical laboratories.]]> Tue 14 May 2024 11:50:59 SAST ]]> The impact of formulation variables on the optimization of pilot scale clobetasol 17-propionate creams https://commons.ru.ac.za/vital/access/manager/Repository/vital:43937 Tue 14 May 2024 11:50:16 SAST ]]> Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media https://commons.ru.ac.za/vital/access/manager/Repository/vital:43929 Tue 14 May 2024 11:49:17 SAST ]]> Preformulation characterization and identification of excipients for nevirapine loaded niosomes https://commons.ru.ac.za/vital/access/manager/Repository/vital:43914 Tue 14 May 2024 11:47:04 SAST ]]> Short term stability testing of efavirenz-loaded solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) dispersions https://commons.ru.ac.za/vital/access/manager/Repository/vital:44000 90%. The optimized nanocarriers exhibited biphasic in vitro release patterns with an initial burst release during the initial 0–3 h followed by sustained release over a 24 h period The colloidal systems showed excellent stability in terms of Zeta potential, particle size, polydispersity index and encapsulation efficiency when stored for 8 weeks at 25 °C/60% RH in comparison to when stored at 40 °C/75% RH. The formulations manufactured using the optimized conditions and composition proved to be physically stable as aqueous dispersions.]]> Tue 14 May 2024 11:14:37 SAST ]]> Preformulation studies of efavirenz with lipid excipients using thermal and spectroscopic techniques https://commons.ru.ac.za/vital/access/manager/Repository/vital:43934 Tue 14 May 2024 11:13:58 SAST ]]> Nano-biomimetic drug delivery vehicles: Potential approaches for COVID-19 treatment https://commons.ru.ac.za/vital/access/manager/Repository/vital:43991 Tue 14 May 2024 11:13:22 SAST ]]> Biocompatibility of biomaterials for nanoencapsulation: Current approaches https://commons.ru.ac.za/vital/access/manager/Repository/vital:43939 Tue 14 May 2024 11:12:53 SAST ]]> Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin https://commons.ru.ac.za/vital/access/manager/Repository/vital:43917 Tue 14 May 2024 11:12:23 SAST ]]> Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets https://commons.ru.ac.za/vital/access/manager/Repository/vital:44192 Tue 14 May 2024 11:05:45 SAST ]]> Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets https://commons.ru.ac.za/vital/access/manager/Repository/vital:44177 Tue 14 May 2024 11:04:25 SAST ]]> Drug transport mechanisms from carbopol/eudragit verapamil sustained-release tablets https://commons.ru.ac.za/vital/access/manager/Repository/vital:44273 Tue 14 May 2024 11:03:40 SAST ]]> The use of response surface methodology in the evaluation of captopril microparticles manufactured using an oil in oil solvent evaporation technique https://commons.ru.ac.za/vital/access/manager/Repository/vital:44191 Tue 14 May 2024 11:03:22 SAST ]]> The impact of manufacturing variables on in vitro release of clobetasol 17-propionate from pilot scale cream formulations https://commons.ru.ac.za/vital/access/manager/Repository/vital:44077 Tue 14 May 2024 11:02:38 SAST ]]> Development and assessment of a USP Apparatus 3 dissolution test method for sustained-release Nevirapine matrix tablets https://commons.ru.ac.za/vital/access/manager/Repository/vital:44271 80% NVP was released from the tablets over the test period. The NVP release rate increased with an increase in the mesh pore size; however, the extent of release was not affected by this parameter. Dissolution test samples were analyzed using HPLC, and dissolution methods were validated for NVP stability in the dissolution medium, specificity, linearity and range, repeatability, intermediate precision, and accuracy as defined by ICH. The dissolution method used for testing NVP tablets can be regarded as an appropriate tool for the evaluation of sustained-release (SR) NVP formulations and the impact of formulation composition and product quality attributes on drug release.]]> Tue 14 May 2024 11:01:21 SAST ]]> The use of experimental design for the development of a capillary zone electrophoresis method for the quantitation of captopril https://commons.ru.ac.za/vital/access/manager/Repository/vital:44073 Tue 14 May 2024 10:59:49 SAST ]]> The use of experimental design for the development and validation of an HPLC-ECD method for the quantitation of efavirenz https://commons.ru.ac.za/vital/access/manager/Repository/vital:44006 Tue 14 May 2024 10:59:25 SAST ]]> Stability indicating HPLC-ECD method for the analysis of clarithromycin in pharmaceutical dosage forms: Method scaling versus re-validation. https://commons.ru.ac.za/vital/access/manager/Repository/vital:43984 Tue 14 May 2024 10:58:54 SAST ]]> Design, evaluation and optimization of taste masked clarithromycin powder https://commons.ru.ac.za/vital/access/manager/Repository/vital:44001 Tue 14 May 2024 10:58:36 SAST ]]> An artificial neural network approach to predict the effects of formulation and process variables on prednisone release from a multipartite system https://commons.ru.ac.za/vital/access/manager/Repository/vital:43933 Tue 14 May 2024 10:58:09 SAST ]]> The use of quantitative analysis and Hansen solubility parameter predictions for the selection of excipients for lipid nanocarriers to be loaded with water soluble and insoluble compounds https://commons.ru.ac.za/vital/access/manager/Repository/vital:43981 Tue 14 May 2024 10:57:46 SAST ]]> Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks https://commons.ru.ac.za/vital/access/manager/Repository/vital:43936 Tue 14 May 2024 10:57:23 SAST ]]> Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form https://commons.ru.ac.za/vital/access/manager/Repository/vital:43926 75% for both hydrochlorothiazide and captopril. The microparticulate technology is able to offer potential resolution to the half-life mediated dosing frequency of captopril as sustained release of the molecule was observed over a 12-h period. The release of hydrochlorothiazide of >80% suggests an improvement in solubility limited dissolution.]]> Tue 14 May 2024 10:56:57 SAST ]]> Design, Optimization, Manufacture and Characterization of Efavirenz-Loaded Flaxseed Oil Nanoemulsions https://commons.ru.ac.za/vital/access/manager/Repository/vital:43919 Tue 14 May 2024 10:55:07 SAST ]]> Assessment of taste masking of captopril by ion-exchange resins using electronic gustatory system https://commons.ru.ac.za/vital/access/manager/Repository/vital:44265 Tue 14 May 2024 10:54:47 SAST ]]> Muco-adhesive clarithromycin-loaded nanostructured lipid carriers for ocular delivery: Formulation, characterization, cytotoxicity and stability https://commons.ru.ac.za/vital/access/manager/Repository/vital:43916 Tue 14 May 2024 10:54:28 SAST ]]> Pharmacokinetics of cyclizine following intravenous administration to human volunteers https://commons.ru.ac.za/vital/access/manager/Repository/vital:44214 Tue 14 May 2024 10:46:29 SAST ]]> Bioequivalence assessment of generic products an innovative South African approach https://commons.ru.ac.za/vital/access/manager/Repository/vital:44194 Tue 14 May 2024 10:40:36 SAST ]]> Suppositories: An underutilized dosage form https://commons.ru.ac.za/vital/access/manager/Repository/vital:44264 Tue 14 May 2024 06:40:41 SAST ]]> In vitro release of amoxycillin from lipophilic suppositories https://commons.ru.ac.za/vital/access/manager/Repository/vital:44213 Tue 14 May 2024 06:39:32 SAST ]]> Co-encapsulation of rifampicin and isoniazid in crude soybean lecithin liposomes https://commons.ru.ac.za/vital/access/manager/Repository/vital:44005 Tue 07 May 2024 15:41:08 SAST ]]> Encapsulation and physicochemical evaluation of efavirenz in liposomes https://commons.ru.ac.za/vital/access/manager/Repository/vital:43988 Tue 07 May 2024 15:38:35 SAST ]]> Co-loading of isoniazid-grafted phthalocyanine-in-cyclodextrin and rifampicin in crude soybean lecithin liposomes: Formulation, spectroscopic and biological characterization https://commons.ru.ac.za/vital/access/manager/Repository/vital:43999 Tue 07 May 2024 15:37:11 SAST ]]> Ultrasound-Triggered Release of 5-Fluorouracil from Soy Lecithin Echogenic Liposomes https://commons.ru.ac.za/vital/access/manager/Repository/vital:43913 Tue 07 May 2024 15:34:35 SAST ]]>