https://commons.ru.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://commons.ru.ac.za/vital/access/manager/Repository/vital:70172 Wed 29 Nov 2023 21:24:48 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65846 Wed 26 Jul 2023 10:19:21 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65774 Wed 26 Jul 2023 09:16:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65767 Wed 26 Jul 2023 09:09:34 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65806 Wed 24 Jan 2024 20:21:09 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65772 Wed 19 Jul 2023 14:31:11 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65765 Wed 19 Jul 2023 10:05:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65793 Wed 10 Jan 2024 11:15:28 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61086 Wed 08 Feb 2023 13:07:39 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61101 Wed 08 Feb 2023 13:07:27 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61139 Wed 08 Feb 2023 13:07:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61088 Wed 08 Feb 2023 13:07:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61140 Wed 08 Feb 2023 13:07:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61100 Wed 08 Feb 2023 08:41:28 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70518 Wed 07 Feb 2024 08:13:03 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70519 Wed 07 Feb 2024 08:12:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65773 Tue 30 Jan 2024 21:24:39 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65777 Tue 30 Jan 2024 21:24:18 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65807 Tue 30 Jan 2024 21:24:10 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65808 Tue 30 Jan 2024 21:24:06 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65790 Tue 25 Jul 2023 16:09:04 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65805 Thu 20 Jul 2023 13:00:00 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65845 Thu 20 Jul 2023 11:57:07 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65803 Thu 13 Jul 2023 15:14:29 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65780 Thu 13 Jul 2023 11:50:00 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65779 Thu 13 Jul 2023 11:36:46 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65778 Thu 13 Jul 2023 11:29:37 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65776 Thu 13 Jul 2023 10:47:08 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65775 100 kDa through ultracentrifugation. Mass spectrometry also detected the most abundant peak for all fucoidans to be around 700 Da (m/z). Extracted fucoidans inhibited the activity of α-glucosidase more strongly than the commercial anti-diabetic agent acarbose but were inactive on α-amylase. Fucoidans were also shown to be mixed inhibitors of α-glucosidase. Compellingly, fucoidans synergistically inhibited α-glucosidase in combination with the anti-diabetic agent acarbose, highlighting prospects for combination therapy. Finally, fucoidans demonstrated some anti-proliferative characteristics on HCT116 cancer cells by inhibiting their ability to adhere to the tissue culture plate matrix. Furthermore, some fucoidan extracts inhibited the migration of HCT116 cancer cells from 3D spheroids. Some of our fucoidan extracts also inhibited HCT116 colony formation, demonstrating inhibition of long-term cell survival. The E. maxima water extract also inhibited glucose uptake by HCT116 cells, thereby influencing the glycolytic flux. In conclusion, biologically active fucoidans were successfully extracted from South African brown seaweeds. These fucoidans demonstrated anti-diabetic and anti-cancer properties, revealing their relevance as potential drugs for these diseases.]]> Thu 11 Jan 2024 18:08:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65763 200 km). These characteristics provide opportunities for high levels of connectivity, and as such, the stock structure is not well understood. We applied an integrated, multidisciplinary approach to provide an improved understanding of the complex stock structure dynamics for Patagonian toothfish on the Patagonian Shelf, specifically in relation to the shelf, slope, and deep-sea plains around the Falkland Islands. Research results were focused on aspects pertaining to (1) geographic variation in phenotypic characters (otolith shape); (2) a description of the spatial-temporal distribution patterns; (3) the active movements of deep-sea adults (tag-recapture study); and (4) the identification of early life-history dispersal through otolith microstructure and microchemical chronologies. Results from the study indicate high regional connectivity during the early life-history stages derived from at least two spawning contingents into spatially discrete nursery areas (cohort groups) on the Falklands Shelf. Fish followed distinct ontogenetic pathways into deeper waters adjacent to the areas wherein juvenile settlement into a demersal habitat occurred. There is little to no evidence of mixing among cohort groups during their ontogenetic migration into deep-sea adult habitats, reflecting a mixed population based on oceanographically defined egg and larval dispersal. The majority of the adult component of the population continue to display high site fidelity. However, between 9 and 25% of the population, consisting predominantly of larger reproductively capable adults undertake long-distance dispersal behaviour, identified as home-range relocations from the adult deep-sea habitats towards three of the known southern spawning grounds in the region. Results are suggestive of a requirement for improved collaborative efforts for regionally-based management approaches with careful consideration of local stock contingents. Future monitoring and research priorities should focus on the identification of reproductive potential, dispersal pathways and settlement patterns of stock contingents to inform the dynamics of mixed stock origins across the Patagonian region. While many aspects regarding the stock structure remain unresolved, results derived from the current studies can be used to inform the development of management measures to ensure the continued recovery and sustainable management of Patagonian toothfish within the region.]]> Thu 11 Jan 2024 18:07:47 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70175 Thu 04 Jan 2024 11:00:40 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61087 Thu 02 Mar 2023 14:38:12 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65792 Sun 21 Jan 2024 14:23:44 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:71954 Sat 06 Apr 2024 12:24:44 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70176 Mon 29 Jan 2024 11:36:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65782 Mon 24 Jul 2023 09:30:24 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70174 Mon 18 Dec 2023 18:08:30 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65764 Mon 17 Jul 2023 11:29:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:61170 Mon 08 Jan 2024 12:35:27 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70177 Mon 05 Feb 2024 08:27:19 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70173 Mon 04 Dec 2023 18:22:10 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65804 S0 excitation energies. The small deviation observed between the calculated and experimental spectra arises from the solvent effect. The excitation energies observed in these UV-Vis spectra mostly originated from electron promotion between the highest occupied molecular orbital (HOMO) for the less intense band and the HOMO-1 for the most intense band of the ground states to the lower unoccupied molecular orbital (LUMO) of the excited states.]]> Fri 17 May 2024 16:29:44 SAST ]]>