https://commons.ru.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://commons.ru.ac.za/vital/access/manager/Repository/vital:41933 Wed 28 Sep 2022 14:29:44 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38503 Wed 12 May 2021 23:20:29 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38418 Wed 12 May 2021 22:48:03 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38696 0.05), allrounders took longer to fall asleep (g = 0.90 [0.23;1.57]), obtained less total sleep (0.76 [0.29;1.42]) and had lower morning freshness scores (g = 1.10 [0.42;1.78]) the night before a match compared to batsmen. Wake after sleep onset and get up time were moderately longer (g = 0.61 [0.22;1.26]) and later (g = 0.62 [0.27;1.17]) before. Twenty20 matches compared to One-Day International matches respectively. Further, sleep duration significantly declined from pre-match to post-match during the multi-day Test format (p = 0.04, g= 0.75 [0.40;1.12]). Late alcohol consumption was significantly (p < 0.05) correlated with a decrease in total sleep time, regardless of match venue (home: rs (49) = -0.69; away: rs (27) = -0.57). During the away condition, an increase in age was significantly associated with longer wake after sleep onset durations (rs (13) = 0.52, p = 0.0003), while greater elite experience was significantly associated with longer total sleep time (rs (72) = 0.36, p = 0.02). The non-sleep medication group took significantly longer to fall asleep compared to the sleep medication group during the first week of the away condition (p = 0.02, g = 0.75 [0.25;1.26]) particularly on nights following transmeridian travel. Although not significant ( p > 0.05), Asian/Indian players had moderately longer sleep onset latencies (g = 1.07 [0.66;1.47]), wake after sleep onset durations (g = 0.86 [0.42;1.29]), and lower subjective sleep quality (g = 0.86 [0.46;1.26]) and morning freshness scores (g = 0.89 [0.47;1.27]) compared to Whites. Similarly, Black Africans had moderately lower subjective sleep quality scores compared to Whites (g = 0.71 [0.43;0.97]). Longer sleep onset latencies and shorter total sleep times were significantly (p < 0.05) associated with poorer One-Day International (rs (28) = -0.57) and Test (rs (12) = 0.59) batting performances respectively. Higher subjective sleep quality scores were significantly associated with better Twenty20 bowling economies (rs (8) = -0.52). Discussion: There was no evidence of poor pre-match sleep behaviour, irrespective of venue; however, the most apparent disruption to sleep occurred post-match (similar to that found in other team-sports). Most disparities in sleep between match venues existed post-travel, with better sleep behaviour observed during the home condition. The differences in sleep patterns found in all three match formats were expected given the variations in format scheduling and duration. Although sleep medication was shown to promote better sleep, its long-term effectiveness was limited. The results promote the implementation of practical strategies aimed to reduce bedtime light-emitting technology use, late evening alcohol consumption and muscle pain. Inter-individual sleep behaviour was found between player roles, age, experience level and race. Moderate associations existed between sleep and markers of batting performance, specifically for the longer, strategic formats of the game. Conclusion: The current study provided new insight of the sleep behaviour in elite South African cricket players during competition. Individualized sleep monitoring practices are encouraged, with specific supervision over older, less experienced players as well as the racial minorities and allrounders of the team. The poor post-match sleep behaviour, together with the sleep and performance correlations, provide ideal opportunities for future interventions to focus on match recovery and the use sleep monitoring as a competitive advantage.]]> Wed 12 May 2021 22:35:34 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37671 A in exon 41 is the most prevalent LRRK2 variation which causes a substitution of glycine to serine in G2019S in the highly activated loop of its MAP kinase domain. The LRRK2 G2019S variant is the most common genetic determinant of Parkinson’s disease identified to date. This work focused on building accurate 3D models of the LRRK2 kinase domain, that were used for large-scale in silico docking against South African natural compounds from the South African Natural Compounds Database (SANCDB; https://sancdb.rubi.ru.ac.za/). Molecular docking was performed to identify compounds that formed interactions with the active site of the protein and had the lowest binding energy scores. Molecular dynamics simulations showed different movements of the protein-ligand complexes and behavioural difference of the wildtype and the variants, all three structures proved to be compact. Network analysis was done to study residue interactions, contact maps, dynamic cross correlations, average BC and average L were used to study the residue interactions and general residue contribution to the functioning of the protein..]]> Wed 12 May 2021 22:17:40 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38243 Wed 12 May 2021 20:52:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38362 Wed 12 May 2021 20:37:27 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:32299 Wed 12 May 2021 20:35:35 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38181 Wed 12 May 2021 20:30:23 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38336 Wed 12 May 2021 20:11:48 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37917 Wed 12 May 2021 20:11:11 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38233 Wed 12 May 2021 19:59:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37984 Wed 12 May 2021 19:52:12 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38352 Wed 12 May 2021 19:51:57 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38253 0.05) results when temperature was analysed by t-test between 2002 and 2015. There was also a weak correlation between length frequency and the total squid catch in a given year (F Statistic (df = 1; 13) is 3.686 and 5.394 for males and females respectively, R² is 0.221 for males and 0.293 for females), but too weak to interpret, given the lack of other supporting data and the short time series. The ML_TW relationship showed no significant trends between the years for either sex. There was also no correlation between the ML_TW and total squid catch or temperature. A white caecum occurred significantly more often in males than in females (dof = 1; p < 0.05) from General Linear Model (GLM), indicating that the presence of non-feeding males in the spawning grounds may be linked to the behaviour of spawning squid.]]> Wed 12 May 2021 19:49:49 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38232 Wed 12 May 2021 19:47:41 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37954 Wed 12 May 2021 19:34:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:32298 Wed 12 May 2021 19:33:52 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:34529 Wed 12 May 2021 19:30:43 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38424 Wed 12 May 2021 19:09:42 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38575 Wed 12 May 2021 18:39:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38373 Wed 12 May 2021 18:28:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37859 Wed 12 May 2021 18:21:20 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:34485 Wed 12 May 2021 18:15:12 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38448 20 m) and rocky habitats were most important in explaining Chambo abundance and detection probability. The size-structure of Chambo in Lake Malawi/Niassa reflects size-specific depth and habitat migrations. Larger Chambo were observed aggregating in waters deeper than 20 m and a broader size range of individuals were observed utilising structured habitat. The effects of fishing are apparent in the size-structure of Chambo in the areas sampled. In study areas exposed to greater levels of fishing pressure – such as Malawi, the BRUVS detected significantly fewer individuals within sexually mature size classes, and the average size was smaller than in areas with less exploitation.]]> Wed 12 May 2021 17:47:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38115 Wed 12 May 2021 17:34:19 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35531 Wed 12 May 2021 17:18:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38540 Wed 12 May 2021 16:46:03 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38796 Wed 12 May 2021 16:31:28 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38395 Wed 12 May 2021 16:14:16 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38400 Wed 12 May 2021 16:00:24 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38411 Wed 12 May 2021 15:56:48 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38071 Wed 12 May 2021 15:54:13 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41462 Wed 12 May 2021 15:10:41 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42788 Wed 12 May 2021 15:10:35 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41152 Wed 12 May 2021 15:10:17 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41028 Wed 12 May 2021 15:08:19 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:40690 Wed 12 May 2021 15:07:39 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41432 Wed 12 May 2021 15:06:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41159 Wed 12 May 2021 15:05:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41013 Wed 12 May 2021 15:04:45 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41154 Wed 12 May 2021 15:03:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41157 Wed 12 May 2021 15:01:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41493 Wed 12 May 2021 15:00:41 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41489 50% cell viability) at concentrations ≤100 μg/mL, however the conjugates showed < 45% cell viability at concentrations ≤ 100 μg/mL, probably due to the small micellar size and EPR effect. The findings from this work show the importance of incorporating photosensitizers such as phthalocyanines into Pluronic polymers micelles and making them water soluble and ultimately improving their photodynamic effect.]]> Wed 12 May 2021 14:58:28 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41439 Wed 12 May 2021 14:58:15 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41467 Wed 12 May 2021 14:57:17 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41332 Wed 12 May 2021 14:56:24 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41123 Wed 12 May 2021 14:55:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41128 Wed 12 May 2021 14:51:15 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41487 Wed 12 May 2021 14:43:34 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41278 Wed 12 May 2021 14:40:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41036 Wed 12 May 2021 14:38:58 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42806 Wed 12 May 2021 14:38:27 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41447 Wed 12 May 2021 14:38:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41377 Wed 12 May 2021 14:34:09 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42173 Wed 12 May 2021 14:32:14 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41484 Wed 12 May 2021 14:28:57 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41458 0.5, suggesting that further development of the assay format to identify GEF and GAP inhibitors may be feasible. In the case of the colorimetric assay, robust signals could be detected and the assay was useful for detecting the activation status of ARF1. However, although the activation of ARF1 by the Sec7 domains of the BIG1 and ARNO was detectable, signals were not robust enough to employ in screening campaigns.]]> Wed 12 May 2021 14:25:48 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41496 Wed 12 May 2021 14:24:42 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41026 Wed 12 May 2021 14:22:46 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41360 Wed 12 May 2021 14:22:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41443 Wed 12 May 2021 14:21:40 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41328 Wed 12 May 2021 14:19:36 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41122 Wed 12 May 2021 14:09:28 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41116 Wed 12 May 2021 14:04:29 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41022 Wed 12 May 2021 14:00:53 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41357 Wed 12 May 2021 14:00:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41440 Wed 12 May 2021 13:53:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:40670 Wed 12 May 2021 13:53:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41027 Wed 12 May 2021 13:50:39 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:40699 Wed 12 May 2021 13:50:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41016 Wed 12 May 2021 13:50:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41163 Wed 12 May 2021 13:49:36 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41501 Wed 12 May 2021 13:47:23 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41333 Wed 12 May 2021 13:45:15 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38711 Wed 03 Jun 2020 14:25:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35439 Thu 13 May 2021 14:04:58 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38512 Thu 13 May 2021 08:11:03 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35406 Thu 13 May 2021 06:50:34 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38427 Thu 13 May 2021 06:17:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35437 Thu 13 May 2021 06:00:27 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38466 Thu 13 May 2021 05:58:42 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37891 Thu 13 May 2021 05:55:46 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38394 Thu 13 May 2021 05:41:52 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38747 Thu 13 May 2021 05:31:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37604 Thu 13 May 2021 05:17:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38102 Thu 13 May 2021 04:58:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37825 Thu 13 May 2021 04:44:54 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:34556 Thu 13 May 2021 04:40:36 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:35593 Thu 13 May 2021 04:26:41 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38543 Thu 13 May 2021 03:27:39 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38658 Thu 13 May 2021 02:30:12 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:39135 Thu 13 May 2021 02:06:50 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37672 Thu 13 May 2021 01:56:21 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:32306 Thu 13 May 2021 01:42:04 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38422 Thu 13 May 2021 01:39:29 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38523 Thu 13 May 2021 00:57:24 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38449 Thu 13 May 2021 00:52:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:38244 Thu 13 May 2021 00:04:36 SAST ]]>