https://commons.ru.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://commons.ru.ac.za/vital/access/manager/Repository/vital:65765 Wed 19 Jul 2023 10:05:25 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45301 Wed 17 Nov 2021 14:45:15 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45295 Wed 17 Nov 2021 10:40:10 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42925 Wed 15 May 2024 19:18:09 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:2529 Wed 12 Oct 2022 11:37:35 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37900 Wed 12 Oct 2022 08:55:28 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37914 Wed 12 May 2021 23:07:48 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7645 Wed 12 May 2021 22:58:53 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:31326 Wed 12 May 2021 22:55:24 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37896 Wed 12 May 2021 22:34:50 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:27832 Wed 12 May 2021 21:06:49 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7647 Wed 12 May 2021 20:49:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:2913 Wed 12 May 2021 20:37:23 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:30555 Wed 12 May 2021 20:35:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:29196 Wed 12 May 2021 20:28:09 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7652 Wed 12 May 2021 19:41:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7869 Wed 12 May 2021 19:37:47 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:30605 Wed 12 May 2021 19:34:18 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37603 Wed 12 May 2021 19:27:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28591 Wed 12 May 2021 19:06:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7646 Wed 12 May 2021 19:00:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7651 Wed 12 May 2021 18:40:43 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7650 Wed 12 May 2021 18:30:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7601 Wed 12 May 2021 16:47:06 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:27435 Wed 12 May 2021 16:40:58 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7644 Wed 12 May 2021 16:24:31 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28156 Wed 12 May 2021 16:21:52 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28133 Wed 12 May 2021 15:50:02 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41014 Wed 12 May 2021 15:10:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41013 Wed 12 May 2021 15:04:45 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41920 Wed 12 May 2021 15:01:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42812 Wed 12 May 2021 14:53:53 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41011 Wed 12 May 2021 14:53:50 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42927 Wed 12 May 2021 14:30:46 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41010 Wed 12 May 2021 14:00:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:41002 Wed 12 May 2021 13:59:29 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42474 Wed 12 May 2021 13:51:58 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:42939 Wed 12 Jul 2023 08:28:50 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45724 Wed 02 Mar 2022 10:25:24 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:49968 100% inhibition in concentrations ≥ 30 μg/mL and TZDD1, 2 and 4 exhibited ≥ 50% inhibition activity in all the concentrations (10, 20, 30, 40 and 50 μg/mL) in the α-amylase inhibition assay. Similarly, in the α-glucosidase inhibition assay, all the four derivatives exhibited a concentration dependent activity with TZDD3 showing the most activity. All the four derivatives exhibited ≥ 30% inhibition in the aldose reductase inhibition assay except TZDD1 at 10 μg/mL. TZDD4 exhibited a concentration dependent inhibition activity in the protein tyrosine phosphatase-1B inhibition assay. Interestingly, TZDD3 showed a decreasing inhibition activity as its concentration increased from 10 μg/mL through to 50 μg/mL. In the dipeptidyl peptidase–4 inhibition assay, TZDD2 and TZDD4 exhibited ≥ 20% inhibition activity across all the concentrations and in the acetylcholinesterase assay, TZDD1, 3 and 4 exhibited ≥ 25% across all the concentrations. Interestingly, in the matrix metalloproteinase-1 inhibition assay, some of these derivatives exhibited partial activation activity and partial inhibition with TZDD1 showing activation in concentrations 10 and 20 μg/mL and inhibition in concentrations 30, 40 and 50 μg/mL. TZDD4 showed activation in all the concentrations. In the β-amyloid aggregation assay, all the four derivatives showed inhibition activity ≥ 10% except TZDD1 at 50 μg/mL. Conclusions Diabetes mellitus and Alzheimer’s disease are a type of pathology of global concern, and several researchers worldwide have strived to search for novel therapeutic treatments and prevention for diabetes as well as Alzheimer’s disease. Recent studies provide a direct link v between diabetes mellitus and Alzheimer’s disease, and the need to find novel drugs that can mitigate these two is of increasing interest. In our search for antidiabetic and anti-Alzheimer’s activity, TZD derivatives (TZDD1, TZDD2, TZDD3 and TZDD4) exhibited good antioxidant activity, anti-hyperglycaemic activity and a relatively promising anti-Alzheimer’s activity. This was observed from the in vitro evaluation performed which included α – amylase, α – glucosidase, aldose reductase, PTP1B, DPP4, amyloid β aggregation, and AChE inhibition assays. Furthermore, docking of the derivatives against PPARγ predicted a similar molecular interaction to that of thiazolidinediones using Rosiglitazone as the standard drug. Furthermore, in silico ADME profiling predicted the derivatives to have moderate to good solubility in the GI (good GI bioavailability), and also exhibited excellent drug likeness. However, they are predicted not permeate the BBB. Further in silico studies and in vivo should be conducted to establish toxicities, as well as drug delivery to the brain for effective therapeutic effect against Alzheimer’s disease.]]> Tue 21 Nov 2023 19:57:12 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70520 Tue 14 May 2024 20:55:59 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45272 Thu 13 Oct 2022 08:40:40 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:19982 Thu 13 May 2021 10:49:20 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:26580 99 % in selectively extracting the metalloporphyrins. The impact of the template on the affinity of recognition for NTPP was evaluated. The results showed that the NTPP adsorption capacity increased as the molar ratio of NTPP to styrene was increased from 1:1 to 3:1. The optimal ratio of template to functional monomer which yielded the best specific affinity and highest recovery (99.9 %) was 3:1. The effects of trifluoroacetic acid (TFA), dichloromethane (DCM), dimethyl sulphoxide (DMSO), pentane (PEN) on electro-spinnability of the polymer solutions and the morphological appearance of the nanofibers were investigated. The imprinted nanofibers exhibited the same selectivity specialism for both NTPP and VTPP. A remarkable stability in relation to reusability was observed when imprinted nanofibers were used, as they could be reused nine times without incurring any significant loss in removal efficiency. The results were validated by analysing a certified reference material. The imprinted sorbents were therefore found to be selective sorbents that are well suited for handling trace metals in organic media.]]> Thu 13 May 2021 09:54:20 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7648 Thu 13 May 2021 08:53:51 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37903 Thu 13 May 2021 08:46:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:30738 Thu 13 May 2021 08:18:40 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7653 Thu 13 May 2021 07:19:46 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28538 Thu 13 May 2021 07:11:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28054 Thu 13 May 2021 06:38:48 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:34081 Thu 13 May 2021 06:38:10 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7649 Thu 13 May 2021 06:18:55 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7883 Thu 13 May 2021 06:15:41 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7593 Thu 13 May 2021 06:07:08 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:3561 Thu 13 May 2021 05:59:34 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28020 Thu 13 May 2021 05:35:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7655 Thu 13 May 2021 05:20:04 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37604 Thu 13 May 2021 05:17:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:30027 5x105 K and >6x1021 W Hz-1 respectively. This work demonstrates that automated post-processing pipelines for wide-field, uniform sensitivity VLBI surveys are feasible and indeed made more efficient with new software, wide-field imaging algorithms and more purpose-built source- finders. This broadens the discovery space for future wide-field surveys with upcoming arrays such as the African VLBI Network (AVN), MeerKAT and the Square Kilometre Array (SKA).]]> Thu 13 May 2021 05:08:27 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28213 Thu 13 May 2021 04:33:28 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7656 Thu 13 May 2021 04:31:37 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28608 Thu 13 May 2021 03:49:57 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:37906 Thu 13 May 2021 03:38:54 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7657 Thu 13 May 2021 03:14:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7654 Thu 13 May 2021 02:04:04 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:31150 Thu 13 May 2021 01:49:42 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:30939 Thu 13 May 2021 01:36:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28105 Thu 13 May 2021 01:32:49 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:27821 Thu 13 May 2021 01:17:53 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:7868 Thu 13 May 2021 00:35:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28533 Thu 09 Mar 2023 09:44:15 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:71669 Sun 25 Feb 2024 09:09:41 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45016 Sun 14 Nov 2021 09:30:22 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:49986 Sun 09 Oct 2022 17:48:47 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72148 Sat 20 Apr 2024 16:38:05 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72147 Sat 20 Apr 2024 16:31:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72143 Sat 20 Apr 2024 15:48:55 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72133 Sat 20 Apr 2024 12:12:41 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72128 10 – 20 mm) and large (20 > 40) body size, flat body, collector-gatherers, free-living, and predators. The late colonisers, collected mainly on day 150 and 180 were dominated by taxa with a preference for high flow velocity (0.3 - 0.6 m/s), permanent attachment, and filter-feeding mode. Traits such as oval and flat body shape, medium body size (>10 - 20 mm), skating and clinging/climbing mobility, temporal attachment, shredders, predators, prey, and plastron and spiracle respiration showed positive correlation with the 100% macroplastic substrates. Filter feeding, crawling, permanent attachment, a preference for fast velocity (0.3-0.6 m/s), and coarse particle organic matter were positively correlated with the 50% macroplastic substrates. Overall, the results provided critical insights on the impact of macroplastics on the assemblage structure of biological communities by acting as suitable habitats in stream ecosystems. The study elucidated the role of traits of aquatic organisms in mediating the colonisation of plastics substrates, providing insights into the impact of plastics proliferation on riverine ecosystem functioning. Furthermore, the finding provides a baseline insight into the influence of hydraulic biotopes on the colonisation and establishment of macroinvertebrates on macroplastic acting as artificial riverine habitat.]]> Sat 20 Apr 2024 11:29:54 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:71961 Sat 06 Apr 2024 14:42:26 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72858 Sat 01 Jun 2024 18:07:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72790 Mon 27 May 2024 19:26:03 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:56783 Mon 26 Sep 2022 09:58:04 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:53636 Mon 25 Jul 2022 15:58:32 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70629 Mon 19 Feb 2024 21:09:31 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65764 Mon 17 Jul 2023 11:29:33 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:45227 Mon 15 Nov 2021 09:59:03 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70632 Mon 13 May 2024 15:48:08 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:51399 Mon 10 Oct 2022 09:11:55 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:40608 Mon 05 Jul 2021 15:12:38 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70173 Mon 04 Dec 2023 18:22:10 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70218 Mon 04 Dec 2023 17:26:19 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:27629 Mon 03 Jul 2023 14:13:59 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65357 Mon 03 Jul 2023 10:33:08 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:65356 Mon 03 Jul 2023 09:30:37 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:70525 Fri 31 May 2024 16:16:13 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:72102 Fri 19 Apr 2024 07:46:03 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:28060 Fri 15 Oct 2021 11:35:53 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:26596 Fri 09 Jun 2023 15:34:31 SAST ]]> https://commons.ru.ac.za/vital/access/manager/Repository/vital:26897 Fri 06 Aug 2021 09:57:38 SAST ]]>