https://commons.ru.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 Synthetic and physical organic studies of chromone derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:4380 Wed 12 May 2021 23:59:48 SAST ]]> Studies directed towards the synthesis of chromone carbaldehyde-derived HIV-1 protease inhibitors https://commons.ru.ac.za/vital/access/manager/Repository/vital:4526 Wed 12 May 2021 22:26:11 SAST ]]> Synthesis and biological evaluation of novel thiazole-based compounds https://commons.ru.ac.za/vital/access/manager/Repository/vital:28325 Wed 12 May 2021 20:04:55 SAST ]]> Studies in asymmetric synthesis https://commons.ru.ac.za/vital/access/manager/Repository/vital:4353 Wed 12 May 2021 19:56:14 SAST ]]> Asymmetric induction in reactions of chiral carboxylic esters and silyl enol ethers https://commons.ru.ac.za/vital/access/manager/Repository/vital:4409 Wed 12 May 2021 19:42:31 SAST ]]> Studies in asymmetric synthesis https://commons.ru.ac.za/vital/access/manager/Repository/vital:4352 Wed 12 May 2021 18:53:15 SAST ]]> Camphor-derived chiral auxiliaries in asymmetric synthesis https://commons.ru.ac.za/vital/access/manager/Repository/vital:4417 99% d.e. for the bomane-2,3-diol acetals. In order to increase diastereofacial selectivity, a camphor-derived diol having a bulky substituent at C-10 was prepared, viz., phenyl 2,3-dihydroxybomane-10sulfonate, and α,β-unsaturated acetals of this diol were shown to undergo Simmons-Smith cyclopropanation with complete topological control (>99% d.e.), the diastereoselectivities being conveniently determined by ¹H and ¹³C NMR spectroscopy. Computer modelling, with the software package HYPERCHEM®, was used to explore the stereochemical aspects of the Simmons-Smith cyclopropanation, and hydrolysis of one of the cyclopropyl acetals has permitted the diastereoselective bias to be confirmed. (+)-Pinane-2,3-diol was also investigated as a chiral auxiliary in the Simmons-Smith reactions of α,β-unsaturated aldehydes, and moderate diastereoselectivities (20-30% d.e.) were observed. In a series of exploratory studies, the Diels-Alder reaction of the 2,3-dihydroxybomane-10-sulfonate acetal of trans-cinnamaldehyde with cyclopentadiene afforded a single cycloadduct, while OSO₄ dihydroxylation, MCPBA oxidation and alkylation of chiral acetals produced from both bomane-2,3-diol and phenyl 2,3-dihydroxybomane-10-sulfonate were less selective.]]> Wed 12 May 2021 18:04:19 SAST ]]> The pyrrolizidine alkaloids of Senecio chrysocoma and Senecio paniculatus https://commons.ru.ac.za/vital/access/manager/Repository/vital:4339 Wed 12 May 2021 17:44:25 SAST ]]> Design, synthesis and evaluation of silver-specific ligands https://commons.ru.ac.za/vital/access/manager/Repository/vital:4308 Wed 12 May 2021 17:34:45 SAST ]]> Synthesis of novel heterocyclic systems as potential inhibitors of HIV-1 enzymes https://commons.ru.ac.za/vital/access/manager/Repository/vital:38531 Wed 12 May 2021 17:09:49 SAST ]]> Baylis-Hillman derived benzopyrans and related systems : a synthetic and mechanistic study https://commons.ru.ac.za/vital/access/manager/Repository/vital:4429 Wed 12 May 2021 16:36:44 SAST ]]> Bayliss-Hillman adducts as scaffolds for the construction of novel compounds with medicinal potential https://commons.ru.ac.za/vital/access/manager/Repository/vital:4410 Wed 12 May 2021 16:23:34 SAST ]]> Applications of Baylis-Idllman methodology in the synthesis of chromene derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:4556 Wed 12 May 2021 16:21:23 SAST ]]> Metathesis catalysts : an integrated computational, mechanistic and synthetic study https://commons.ru.ac.za/vital/access/manager/Repository/vital:4397 Wed 12 May 2021 16:09:45 SAST ]]> Chemical studies of chromone derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:4424 Wed 12 May 2021 16:06:45 SAST ]]> Novel applications of Morita-Baylis-Hillman methodology in organic synthesis https://commons.ru.ac.za/vital/access/manager/Repository/vital:4439 Wed 12 May 2021 15:44:41 SAST ]]> Application of computational methods in elucidating the isomerization step in the biosynthesis of coumarins https://commons.ru.ac.za/vital/access/manager/Repository/vital:29124 Tue 11 Jul 2023 16:25:27 SAST ]]> Synthetic and spectroscopic studies of 1,4-benzodiazepine analogues https://commons.ru.ac.za/vital/access/manager/Repository/vital:4384 Thu 13 May 2021 14:13:15 SAST ]]> Synthetic and analytical studies of biomimetic metal complexes https://commons.ru.ac.za/vital/access/manager/Repository/vital:4377 Thu 13 May 2021 10:50:32 SAST ]]> Design, synthesis and evaluation of novel, metal complexing agents https://commons.ru.ac.za/vital/access/manager/Repository/vital:4307 Thu 13 May 2021 08:49:15 SAST ]]> Synthetic and spectroscopic studies of indolizine derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:4385 Thu 13 May 2021 06:58:04 SAST ]]> Synthesis of chiral ketopinic acid-derived catalysts and their evaluation in asymmetric transformations https://commons.ru.ac.za/vital/access/manager/Repository/vital:19969 Thu 13 May 2021 06:44:11 SAST ]]> Synthetic, spectrometric and computer modelling studies of novel ATP analogues https://commons.ru.ac.za/vital/access/manager/Repository/vital:4386 Thu 13 May 2021 06:22:18 SAST ]]> ATP mimics as glutamine synthetase inhibitors : an exploratory synthetic study https://commons.ru.ac.za/vital/access/manager/Repository/vital:4408 Thu 13 May 2021 05:07:50 SAST ]]> Synthetic and spectrometric studies of benzodioxepinone derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:4382 Thu 13 May 2021 04:50:07 SAST ]]> Synthesis and evaluation of novel HIV-1 enzyme inhibitors https://commons.ru.ac.za/vital/access/manager/Repository/vital:4369 Thu 13 May 2021 03:41:05 SAST ]]> Mechanistic studies of unusual Miruta-Baylis-Hillman reactions https://commons.ru.ac.za/vital/access/manager/Repository/vital:4400 Thu 13 May 2021 02:57:41 SAST ]]> Applications of the Baylis-Hillman reaction in the synthesis of coumarin derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:4403 Thu 13 May 2021 02:48:57 SAST ]]> Application of Baylis-Hillman methodology in the construction of complex heterocyclic targets https://commons.ru.ac.za/vital/access/manager/Repository/vital:4401 Thu 13 May 2021 02:42:41 SAST ]]> Physical organic studies of substituted norbornyl systems: aspects of mechanisms and chirality https://commons.ru.ac.za/vital/access/manager/Repository/vital:25999 Thu 13 May 2021 02:42:08 SAST ]]> Chemical studies of selected chromone derivatives https://commons.ru.ac.za/vital/access/manager/Repository/vital:4434 Thu 13 May 2021 02:00:59 SAST ]]> Synthesis of novel inhibitors of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase as potential anti-malarial lead compounds https://commons.ru.ac.za/vital/access/manager/Repository/vital:4372 Thu 13 May 2021 01:49:31 SAST ]]> Biocatalytic and biomimetic studies of polyphenol oxidase https://commons.ru.ac.za/vital/access/manager/Repository/vital:4028 Fri 06 Aug 2021 10:23:20 SAST ]]>