- Title
- NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum:
- Creator
- Veale, Clinton G L, Chen, Weiyang, Chaudhary, Sushil, Kituyi, Sarah N, Isaacs, Michelle, Hoppe, Heinrich C, Edkins, Adrienne L, Combrinck, Sandra, Mehari, Bewketu, Viljoen, Alvaro
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/164345
- Identifier
- vital:41110
- Identifier
- DOI: 10.1016/j.phytol.2017.11.018
- Description
- Chemical interrogation of the Sceletium genus and Amaryllidaceae family of plants has yielded a diverse array of aryl-hydroindole containing alkaloids. Included in this class is channaine, which was tentatively identified, without comprehensive structural elucidation from Sceletium tortuosum in 1957. Following its isolation from S. strictum, the structure of channaine was eventually resolved by X-ray crystallographic analysis, which revealed an unusual cage-like ring structure at the interface of two aryl-hydroindole subunits. However, since this report in 1978, channaine has not re-appeared in the literature. In this letter, the full NMR characterisation of channaine, isolated from S. tortuosum collected from St Helena in the Western Cape Province of South Africa, is reported for the first time.
- Format
- 5 pages, pdf
- Language
- English
- Relation
- Phytochemistry Letters, Veale, C.G., Chen, W., Chaudhary, S., Kituyi, S.N., Isaacs, M., Hoppe, H., Edkins, A.L., Combrinck, S., Mehari, B. and Viljoen, A., 2018. NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum. Phytochemistry Letters, 23, pp.189-193, Phytochemistry Letters volume 23 number 189 193 February 2018 1876-7486
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Collections
RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
Edkins, Adrienne Lesley (Associate Prof)
Veale, Clinton G L (Dr)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Pharmacy
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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