- Title
- Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.
- Creator
- Mbaba, Mziyanda, de la Mare, Jo-Anne, Sterrenberg, Jason N, Kajewole, Deborah, Maharaj, Shantal, Edkins, Adrienne L, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/122858
- Identifier
- vital:35359
- Identifier
- https://doi.org/10.1007/s00775-018-1634-9
- Description
- A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
- Format
- 10 pages, pdf
- Language
- English
- Relation
- JBIC Journal of Biological Inorganic Chemistry, Mbaba, M., de la Mare, J.A., Sterrenberg, J.N., Kajewole, D., Maharaj, S., Edkins, A.L., Isaacs, M., Hoppe, H.C. and Khanye, S.D., 2019. Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition. JBIC Journal of Biological Inorganic Chemistry, 24(2), pp.139-149., JBIC Journal of Biological Inorganic Chemistry number 24 139 149 2018 1432-1327
- Rights
- JBIC Journal of Biological Inorganic Chemistry
- Rights
- Use of this resource is governed by the SpringerLink Terms of Use Statement (https://link.springer.com/termsandconditions)
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Collections
De la Mare, Jo-Anne (Dr)
Edkins, Adrienne Lesley (Associate Prof)
Khanye, David Setshaba (Associate Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
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